SIMILAR PATTERNS OF AMINO ACIDS FOR 6A5Y_D_9CRD501_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bvs PROTEIN (HOLLIDAY
JUNCTION DNA
HELICASE RUVA)

(Mycobacterium
leprae) 		PF01330
(RuvA_N)
PF07499
(RuvA_C)
PF14520
(HHH_5) 		3 ASN A  67
VAL A 112
HIS A  92
 None
 0.82A 6a5yD-1bvsA:
undetectable		 6a5yD-1bvsA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gvh FLAVOHEMOPROTEIN

(Escherichia
coli) 		PF00042
(Globin)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		3 ASN A 238
VAL A 221
HIS A 234
 None
FAD  A1397 (-3.5A)
None
 0.47A 6a5yD-1gvhA:
0.4		 6a5yD-1gvhA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ir6 EXONUCLEASE RECJ

(Thermus
thermophilus) 		PF01368
(DHH)
PF02272
(DHHA1) 		3 ASN A 151
VAL A 117
HIS A 125
 None
 0.72A 6a5yD-1ir6A:
undetectable		 6a5yD-1ir6A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jv1 GLCNAC1P
URIDYLTRANSFERASE
ISOFORM 1: AGX1

(Homo sapiens) 		PF01704
(UDPGP) 		3 ASN A 254
VAL A 382
HIS A 331
 None
 0.84A 6a5yD-1jv1A:
undetectable		 6a5yD-1jv1A:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kug METALLOPROTEINASE

(Protobothrops
mucrosquamatus) 		PF01421
(Reprolysin) 		3 ASN A 104
VAL A 138
HIS A 131
 None
None
CD  A 988 (-3.3A)
 0.86A 6a5yD-1kugA:
0.0		 6a5yD-1kugA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE

(Saccharomyces
cerevisiae) 		PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5) 		3 ASN A 501
VAL A 396
HIS A 398
 None
 0.84A 6a5yD-1la2A:
undetectable		 6a5yD-1la2A:
8.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lox 15-LIPOXYGENASE

(Oryctolagus
cuniculus) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		3 ASN A 152
VAL A 661
HIS A 366
 None
None
FE2  A 840 (-3.4A)
 0.74A 6a5yD-1loxA:
2.0		 6a5yD-1loxA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r53 CHORISMATE SYNTHASE

(Saccharomyces
cerevisiae) 		PF01264
(Chorismate_synt) 		3 ASN A 289
VAL A 266
HIS A 271
 None
 0.74A 6a5yD-1r53A:
0.0		 6a5yD-1r53A:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1smr RENIN

(Mus musculus) 		PF00026
(Asp) 		3 ASN A  37
VAL A  96
HIS A 139
 None
 0.84A 6a5yD-1smrA:
undetectable		 6a5yD-1smrA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tlt PUTATIVE
OXIDOREDUCTASE
(VIRULENCE FACTOR
MVIM HOMOLOG)

(Escherichia
coli) 		PF01408
(GFO_IDH_MocA) 		3 ASN A 101
VAL A  94
HIS A  78
 None
 0.51A 6a5yD-1tltA:
undetectable		 6a5yD-1tltA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txk GLUCANS BIOSYNTHESIS
PROTEIN G

(Escherichia
coli) 		PF04349
(MdoG) 		3 ASN A  65
VAL A 118
HIS A 120
 None
 0.81A 6a5yD-1txkA:
undetectable		 6a5yD-1txkA:
9.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uhl RETINOIC ACID
RECEPTOR RXR-BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		3 ASN A 377
VAL A 413
HIS A 506
 None
MEI  A1001 (-4.1A)
None
 0.67A 6a5yD-1uhlA:
35.5		 6a5yD-1uhlA:
79.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uxe FIBER PROTEIN

(Human
mastadenovirus
D) 		PF00541
(Adeno_knob) 		3 ASN A 234
VAL A 225
HIS A 231
 None
None
ZN  A1366 ( 3.2A)
 0.87A 6a5yD-1uxeA:
undetectable		 6a5yD-1uxeA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1

(Pyrococcus
furiosus) 		PF00291
(PALP) 		3 ASN B 369
VAL B 322
HIS B 348
 None
 0.82A 6a5yD-1wdwB:
undetectable		 6a5yD-1wdwB:
10.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xiu RXR-LIKE PROTEIN

(Biomphalaria
glabrata) 		PF00104
(Hormone_recep) 		3 ASN A 280
VAL A 316
HIS A 409
 None
9CR  A 201 (-4.2A)
9CR  A 201 (-4.8A)
 0.33A 6a5yD-1xiuA:
32.3		 6a5yD-1xiuA:
75.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xls RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		3 ASN A 306
VAL A 342
HIS A 435
 None
9CR  A 801 ( 4.3A)
None
 0.24A 6a5yD-1xlsA:
34.9		 6a5yD-1xlsA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xuq SUPEROXIDE DISMUTASE

(Bacillus
anthracis) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		3 ASN A  34
VAL A  55
HIS A   4
 None
 0.83A 6a5yD-1xuqA:
undetectable		 6a5yD-1xuqA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yac YCAC GENE PRODUCT

(Escherichia
coli) 		PF00857
(Isochorismatase) 		3 ASN A  38
VAL A 113
HIS A  20
 None
 0.85A 6a5yD-1yacA:
undetectable		 6a5yD-1yacA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c81 GLUTAMINE-2-DEOXY-SC
YLLO-INOSOSE
AMINOTRANSFERASE

(Bacillus
circulans) 		PF01041
(DegT_DnrJ_EryC1) 		3 ASN A 275
VAL A 193
HIS A 390
 None
 0.76A 6a5yD-2c81A:
undetectable		 6a5yD-2c81A:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1u IRON(III) DICITRATE
TRANSPORT PROTEIN
FECA

(Escherichia
coli) 		PF07660
(STN) 		3 ASN A  15
VAL A  46
HIS A  20
 None
 0.75A 6a5yD-2d1uA:
undetectable		 6a5yD-2d1uA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7s RNA-DEPENDENT RNA
POLYMERASE

(Foot-and-mouth
disease virus) 		PF00680
(RdRP_1) 		3 ASN A 206
VAL A 260
HIS A  86
 None
 0.74A 6a5yD-2d7sA:
undetectable		 6a5yD-2d7sA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d9v PLECKSTRIN HOMOLOGY
DOMAIN-CONTAINING
PROTEIN FAMILY B
MEMBER 1

(Mus musculus) 		PF00169
(PH) 		3 ASN A  27
VAL A  70
HIS A  93
 None
 0.87A 6a5yD-2d9vA:
undetectable		 6a5yD-2d9vA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dhx POLY (ADP-RIBOSE)
POLYMERASE FAMILY,
MEMBER 10 VARIANT

(Homo sapiens) 		no annotation 3 ASN A  31
VAL A  20
HIS A  72
 None
 0.74A 6a5yD-2dhxA:
undetectable		 6a5yD-2dhxA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ec5 DERMONECROTIC TOXIN

(Pasteurella
multocida) 		PF11647
(MLD) 		3 ASN A 625
VAL A 590
HIS A 622
 None
 0.75A 6a5yD-2ec5A:
undetectable		 6a5yD-2ec5A:
6.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6d GLUCOAMYLASE GLU1

(Saccharomycopsis
fibuligera) 		PF00723
(Glyco_hydro_15) 		3 ASN A 455
VAL A 443
HIS A 447
 None
None
ACR  A 996 (-3.4A)
 0.87A 6a5yD-2f6dA:
undetectable		 6a5yD-2f6dA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk7 SHIKIMATE
DEHYDROGENASE

(Aquifex
aeolicus) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		3 ASN A 201
VAL A 181
HIS A 209
 None
 0.79A 6a5yD-2hk7A:
undetectable		 6a5yD-2hk7A:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i58 SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF13416
(SBP_bac_8) 		3 ASN A 296
VAL A   6
HIS A 291
 None
 0.81A 6a5yD-2i58A:
undetectable		 6a5yD-2i58A:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ibu ACETYL-COA
ACETYLTRANSFERASE

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		3 ASN A 189
VAL A 180
HIS A 192
 None
None
COA  A6001 (-4.5A)
 0.86A 6a5yD-2ibuA:
undetectable		 6a5yD-2ibuA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3t TRAFFICKING PROTEIN
PARTICLE COMPLEX
SUBUNIT 1

(Mus musculus) 		PF04099
(Sybindin) 		3 ASN C   5
VAL C  90
HIS C  72
 None
 0.88A 6a5yD-2j3tC:
undetectable		 6a5yD-2j3tC:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jhq URACIL
DNA-GLYCOSYLASE

(Vibrio cholerae) 		PF03167
(UDG) 		3 ASN A 123
VAL A  27
HIS A 136
 None
 0.86A 6a5yD-2jhqA:
undetectable		 6a5yD-2jhqA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kii PUTATIVE
UNCHARACTERIZED
PROTEIN

(Shewanella
oneidensis) 		PF07700
(HNOB) 		3 ASN A   7
VAL A 106
HIS A  81
 None
HEM  A 182 (-4.0A)
HEM  A 182 (-2.9A)
 0.75A 6a5yD-2kiiA:
undetectable		 6a5yD-2kiiA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN

(Porphyromonas
gingivalis) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		3 ASN A  51
VAL A  15
HIS A  16
 ASN  A  51 ( 0.6A)
VAL  A  15 ( 0.6A)
HIS  A  16 ( 1.0A)
 0.83A 6a5yD-2nvvA:
undetectable		 6a5yD-2nvvA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE

(Cryptosporidium
parvum) 		PF00348
(polyprenyl_synt) 		3 ASN A  30
VAL A  68
HIS A  73
 None
 0.83A 6a5yD-2o1oA:
undetectable		 6a5yD-2o1oA:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6l UDP-GLUCURONOSYLTRAN
SFERASE 2B7

(Homo sapiens) 		PF00201
(UDPGT) 		3 ASN A 360
VAL A 296
HIS A 365
 None
 0.85A 6a5yD-2o6lA:
undetectable		 6a5yD-2o6lA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pk0 SERINE/THREONINE
PROTEIN PHOSPHATASE
STP1

(Streptococcus
agalactiae) 		PF13672
(PP2C_2) 		3 ASN A 160
VAL A 116
HIS A 136
 None
 0.84A 6a5yD-2pk0A:
undetectable		 6a5yD-2pk0A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppv UNCHARACTERIZED
PROTEIN

(Staphylococcus
epidermidis) 		PF01933
(UPF0052) 		3 ASN A 290
VAL A 217
HIS A 302
 None
 0.64A 6a5yD-2ppvA:
undetectable		 6a5yD-2ppvA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyu INOSINE TRIPHOSPHATE
PYROPHOSPHATASE RDGB

(Escherichia
coli) 		PF01725
(Ham1p_like) 		3 ASN A  49
VAL A  36
HIS A  56
 None
 0.79A 6a5yD-2pyuA:
undetectable		 6a5yD-2pyuA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1f CHONDROITINASE

(Bacteroides
thetaiotaomicron) 		PF02278
(Lyase_8)
PF09092
(Lyase_N)
PF09093
(Lyase_catalyt) 		3 ASN A 573
VAL A 463
HIS A 526
 None
 0.78A 6a5yD-2q1fA:
undetectable		 6a5yD-2q1fA:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q7x UPF0052 PROTEIN
SP_1565

(Streptococcus
pneumoniae) 		PF01933
(UPF0052) 		3 ASN A  60
VAL A 221
HIS A 308
 None
 0.70A 6a5yD-2q7xA:
undetectable		 6a5yD-2q7xA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rm6 GLUTATHIONE
PEROXIDASE-LIKE
PROTEIN

(Trypanosoma
brucei) 		PF00255
(GSHPx) 		3 ASN A  77
VAL A  20
HIS A 116
 None
 0.88A 6a5yD-2rm6A:
undetectable		 6a5yD-2rm6A:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uzx HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF01403
(Sema)
PF01437
(PSI)
PF01833
(TIG) 		3 ASN B 594
VAL B 465
HIS B 476
 None
 0.86A 6a5yD-2uzxB:
undetectable		 6a5yD-2uzxB:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v0j BIFUNCTIONAL PROTEIN
GLMU

(Haemophilus
influenzae) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		3 ASN A 305
VAL A 252
HIS A 268
 None
 0.84A 6a5yD-2v0jA:
undetectable		 6a5yD-2v0jA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vmf BETA-MANNOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2) 		3 ASN A  71
VAL A  84
HIS A  60
 None
 0.69A 6a5yD-2vmfA:
undetectable		 6a5yD-2vmfA:
7.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5e PROTEASOME
ASSEMBLING CHAPERONE
3

(Homo sapiens) 		PF10178
(PAC3) 		3 ASN A  81
VAL A  66
HIS A  76
 None
 0.70A 6a5yD-2z5eA:
undetectable		 6a5yD-2z5eA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbz CYTOCHROME P450-SU1

(Streptomyces
griseolus) 		PF00067
(p450) 		3 ASN A  72
VAL A 352
HIS A 103
 None
None
HEM  A 413 (-3.9A)
 0.57A 6a5yD-2zbzA:
undetectable		 6a5yD-2zbzA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3h ENDOGLUCANASE

(Salipaludibacillus
agaradhaerens) 		PF00150
(Cellulase) 		3 ASN A 131
VAL A  27
HIS A   9
 None
 0.78A 6a5yD-3a3hA:
undetectable		 6a5yD-3a3hA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e77 PHOSPHOSERINE
AMINOTRANSFERASE

(Homo sapiens) 		PF00266
(Aminotran_5) 		3 ASN A 297
VAL A 338
HIS A 158
 None
 0.86A 6a5yD-3e77A:
undetectable		 6a5yD-3e77A:
11.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3eyb NUCLEAR HORMONE
RECEPTOR RXR

(Branchiostoma
floridae) 		PF00104
(Hormone_recep) 		3 ASN A 335
VAL A 371
HIS A 464
 None
 0.60A 6a5yD-3eybA:
29.0		 6a5yD-3eybA:
75.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxg RHAMNONATE
DEHYDRATASE

(Fusarium
graminearum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ASN A 290
VAL A 235
HIS A 265
 None
 0.72A 6a5yD-3fxgA:
undetectable		 6a5yD-3fxgA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7s LONG-CHAIN-FATTY-ACI
D--COA LIGASE
(FADD-1)

(Archaeoglobus
fulgidus) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 ASN A 135
VAL A 151
HIS A 129
 None
 0.87A 6a5yD-3g7sA:
undetectable		 6a5yD-3g7sA:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcg L0028 (MITOCHONDRIA
ASSOCIATED PROTEIN)

(Escherichia
coli) 		PF03278
(IpaB_EvcA) 		3 ASN B  56
VAL B 169
HIS B  51
 None
 0.68A 6a5yD-3gcgB:
undetectable		 6a5yD-3gcgB:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5t AMINOTRANSFERASE

(Rhodobacter
sphaeroides) 		PF00202
(Aminotran_3) 		3 ASN A 169
VAL A 148
HIS A 154
 None
 0.68A 6a5yD-3i5tA:
undetectable		 6a5yD-3i5tA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k55 BETA-HEMOLYSIN

(Staphylococcus
aureus) 		PF03372
(Exo_endo_phos) 		3 ASN A 214
VAL A 178
HIS A 254
 None
 0.87A 6a5yD-3k55A:
undetectable		 6a5yD-3k55A:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kcu PROBABLE FORMATE
TRANSPORTER 1

(Escherichia
coli) 		PF01226
(Form_Nir_trans) 		3 ASN A 241
VAL A 157
HIS A 244
 None
 0.85A 6a5yD-3kcuA:
undetectable		 6a5yD-3kcuA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl0 GLUCURONOXYLANASE
XYNC

(Bacillus
subtilis) 		PF17189
(Glyco_hydro_30C) 		3 ASN A 162
VAL A  56
HIS A 117
 None
 0.81A 6a5yD-3kl0A:
undetectable		 6a5yD-3kl0A:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwe ATP-CITRATE SYNTHASE

(Homo sapiens) 		PF16114
(Citrate_bind) 		3 ASN A 203
VAL A 111
HIS A 113
 None
 0.84A 6a5yD-3mweA:
undetectable		 6a5yD-3mweA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0q PUTATIVE
AROMATIC-RING
HYDROXYLATING
DIOXYGENASE

(Ruegeria sp.
TM1040) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		3 ASN A  11
VAL A  28
HIS A   2
 None
 0.81A 6a5yD-3n0qA:
undetectable		 6a5yD-3n0qA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6r PROPIONYL-COA
CARBOXYLASE, ALPHA
SUBUNIT

(Ruegeria
pomeroyi) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		3 ASN A 398
VAL A 475
HIS A 480
 None
 0.79A 6a5yD-3n6rA:
undetectable		 6a5yD-3n6rA:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odp PUTATIVE
TAGATOSE-6-PHOSPHATE
KETOSE/ALDOSE
ISOMERASE

(Clostridium
novyi) 		PF01380
(SIS) 		3 ASN A 145
VAL A 127
HIS A 153
 None
 0.82A 6a5yD-3odpA:
undetectable		 6a5yD-3odpA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pig BETA-FRUCTOFURANOSID
ASE

(Bifidobacterium
longum) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		3 ASN A 272
VAL A 431
HIS A 299
 None
 0.80A 6a5yD-3pigA:
undetectable		 6a5yD-3pigA:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pmc UNCHARACTERIZED
PROTEIN
PXO2-61/BXB0075/GBAA
_PXO2_0075

(Bacillus
anthracis) 		PF09385
(HisK_N) 		3 ASN A  80
VAL A  27
HIS A  86
 None
 0.85A 6a5yD-3pmcA:
undetectable		 6a5yD-3pmcA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q8n 4-AMINOBUTYRATE
TRANSAMINASE

(Mycolicibacterium
smegmatis) 		PF00202
(Aminotran_3) 		3 ASN A  64
VAL A 411
HIS A 405
 None
 0.81A 6a5yD-3q8nA:
undetectable		 6a5yD-3q8nA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rde ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE

(Sus scrofa) 		PF00305
(Lipoxygenase) 		3 ASN A 152
VAL A 661
HIS A 366
 None
None
FE2  A   1 ( 3.4A)
 0.79A 6a5yD-3rdeA:
undetectable		 6a5yD-3rdeA:
8.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr7 URACIL-DNA
GLYCOSYLASE

(Coxiella
burnetii) 		PF03167
(UDG) 		3 ASN A 125
VAL A  30
HIS A 138
 None
 0.87A 6a5yD-3tr7A:
undetectable		 6a5yD-3tr7A:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ty9 POLYNUCLEOTIDE
2',3'-CYCLIC
PHOSPHATE
PHOSPHODIESTERASE /
POLYNUCLEOTIDE
5'-HYDROXYL-KINASE /
POLYNUCLEOTIDE
3'-PHOSPHATASE

(Ruminiclostridium
thermocellum) 		PF16536
(PNKP-ligase_C)
PF16542
(PNKP_ligase) 		3 ASN A 718
VAL A 713
HIS A 714
 None
 0.85A 6a5yD-3ty9A:
undetectable		 6a5yD-3ty9A:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxf UNCHARACTERIZED
PROTEIN

(Danio rerio) 		PF00443
(UCH) 		3 ASN A 860
VAL A 722
HIS A 854
 None
 0.88A 6a5yD-3wxfA:
undetectable		 6a5yD-3wxfA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aig ADAMALYSIN II

(Crotalus
adamanteus) 		PF01421
(Reprolysin) 		3 ASN A 102
VAL A 136
HIS A 129
 None
 0.87A 6a5yD-4aigA:
undetectable		 6a5yD-4aigA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4apl APICAL MEMBRANE
ANTIGEN 1

(Neospora
caninum) 		PF02430
(AMA-1) 		3 ASN A 282
VAL A  89
HIS A  85
 None
 0.85A 6a5yD-4aplA:
undetectable		 6a5yD-4aplA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci0 F420-REDUCING
HYDROGENASE, SUBUNIT
ALPHA

(Methanothermobacter
marburgensis) 		PF00374
(NiFeSe_Hases) 		3 ASN A 104
VAL A 186
HIS A 185
 None
 0.79A 6a5yD-4ci0A:
undetectable		 6a5yD-4ci0A:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fnv HEPARINASE III
PROTEIN, HEPARITIN
SULFATE LYASE

(Bacteroides
thetaiotaomicron) 		PF07940
(Hepar_II_III)
PF16889
(Hepar_II_III_N) 		3 ASN A 374
VAL A 353
HIS A 315
 None
 0.80A 6a5yD-4fnvA:
undetectable		 6a5yD-4fnvA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lyl URACIL-DNA
GLYCOSYLASE

(Gadus morhua) 		PF03167
(UDG) 		3 ASN A 204
VAL A 109
HIS A 217
 None
 0.83A 6a5yD-4lylA:
undetectable		 6a5yD-4lylA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nb0 METALLOTHIOL
TRANSFERASE FOSB

(Staphylococcus
aureus) 		PF00903
(Glyoxalase) 		3 ASN A  89
VAL A  12
HIS A 112
 None
 0.67A 6a5yD-4nb0A:
undetectable		 6a5yD-4nb0A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzj PUTATIVE
ALPHA-GALACTOSIDASE

(Bacteroides
fragilis) 		PF05345
(He_PIG)
PF10632
(He_PIG_assoc)
PF16499
(Melibiase_2) 		3 ASN A 339
VAL A 273
HIS A 294
 None
 0.86A 6a5yD-4nzjA:
undetectable		 6a5yD-4nzjA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ogz PUTATIVE
ALPHA-GALACTOSIDASE/
MELIBIASE

(Bacteroides
fragilis) 		PF10632
(He_PIG_assoc)
PF16499
(Melibiase_2)
PF17450
(Melibiase_2_C) 		3 ASN A 339
VAL A 273
HIS A 294
 None
 0.86A 6a5yD-4ogzA:
undetectable		 6a5yD-4ogzA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxg TYPE-2 RESTRICTION
ENZYME SAU3AI

(Staphylococcus
aureus) 		PF02976
(MutH) 		3 ASN A 478
VAL A 358
HIS A 307
 None
 0.83A 6a5yD-4pxgA:
undetectable		 6a5yD-4pxgA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qr8 XAA-PRO DIPEPTIDASE

(Escherichia
coli) 		PF00557
(Peptidase_M24) 		3 ASN A 179
VAL A 212
HIS A 207
 None
 0.85A 6a5yD-4qr8A:
undetectable		 6a5yD-4qr8A:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1z CYP17A1 PROTEIN

(Danio rerio) 		PF00067
(p450) 		3 ASN A 406
VAL A 392
HIS A  94
 None
 0.77A 6a5yD-4r1zA:
undetectable		 6a5yD-4r1zA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upk PHOSPHONATE
MONOESTER HYDROLASE

(Ruegeria
pomeroyi) 		PF00884
(Sulfatase) 		3 ASN A 487
VAL A  72
HIS A  69
 None
 0.81A 6a5yD-4upkA:
undetectable		 6a5yD-4upkA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		3 ASN A 863
VAL A 778
HIS A 827
 None
 0.54A 6a5yD-4w8jA:
undetectable		 6a5yD-4w8jA:
5.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wh0 PUTATIVE HYDROLASE

(Pseudomonas
aeruginosa) 		PF00857
(Isochorismatase) 		3 ASN A  38
VAL A 113
HIS A  20
 None
 0.82A 6a5yD-4wh0A:
undetectable		 6a5yD-4wh0A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yry DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A

(Thermotoga
maritima) 		PF07992
(Pyr_redox_2)
PF14691
(Fer4_20) 		3 ASN B 289
VAL B  23
HIS B 326
 FAD  B 503 (-3.8A)
None
None
 0.80A 6a5yD-4yryB:
undetectable		 6a5yD-4yryB:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yu5 IMMUNE INHIBITOR A,
METALLOPROTEASE

(Bacillus cereus) 		PF05547
(Peptidase_M6) 		3 ASN A 764
VAL A 753
HIS A 701
 None
 0.87A 6a5yD-4yu5A:
undetectable		 6a5yD-4yu5A:
7.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5afd N-ACETYLNEURAMINATE
LYASE

(Aliivibrio
salmonicida) 		PF00701
(DHDPS) 		3 ASN A  22
VAL A 254
HIS A  12
 None
 0.53A 6a5yD-5afdA:
undetectable		 6a5yD-5afdA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cfa BONE
SIALOPROTEIN-BINDING
PROTEIN

(Staphylococcus
aureus) 		PF10425
(SdrG_C_C) 		3 ASN A 143
VAL A 123
HIS A  59
 None
 0.79A 6a5yD-5cfaA:
undetectable		 6a5yD-5cfaA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chv UBL
CARBOXYL-TERMINAL
HYDROLASE 18

(Mus musculus) 		PF00443
(UCH) 		3 ASN A  56
VAL A 129
HIS A 135
 None
SO4  A 402 ( 4.0A)
SO4  A 402 (-3.5A)
 0.75A 6a5yD-5chvA:
undetectable		 6a5yD-5chvA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9u GLYCOSYLTRANSFERASE-
STABILIZING PROTEIN
GTF2

(Streptococcus
gordonii) 		no annotation 3 ASN B 338
VAL B 363
HIS B 293
 None
 0.86A 6a5yD-5e9uB:
undetectable		 6a5yD-5e9uB:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f6q METALLOTHIOL
TRANSFERASE FOSB 2

(Bacillus
anthracis) 		PF00903
(Glyoxalase) 		3 ASN A  89
VAL A  12
HIS A 112
 None
 0.81A 6a5yD-5f6qA:
undetectable		 6a5yD-5f6qA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jfc NADH-DEPENDENT
FERREDOXIN:NADP
OXIDOREDUCTASE
SUBUNIT ALPHA

(Pyrococcus
furiosus) 		PF07992
(Pyr_redox_2)
PF14691
(Fer4_20) 		3 ASN L 303
VAL L  26
HIS L 339
 FAD  L 503 (-3.7A)
None
None
 0.78A 6a5yD-5jfcL:
undetectable		 6a5yD-5jfcL:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1s OXIDOREDUCTASE,
ZINC-BINDING
DEHYDROGENASE FAMILY

(Myxococcus
xanthus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 ASN A 331
VAL A  39
HIS A 326
 None
 0.85A 6a5yD-5k1sA:
undetectable		 6a5yD-5k1sA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5koj NITROGENASE PROTEIN
ALPHA CHAIN

(Gluconacetobacter
diazotrophicus) 		PF00148
(Oxidored_nitro) 		3 ASN A 114
VAL A 371
HIS A 458
 None
ICS  A 502 ( 4.4A)
ICS  A 502 ( 3.6A)
 0.75A 6a5yD-5kojA:
undetectable		 6a5yD-5kojA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lwg VP3

(Israeli acute
paralysis virus) 		no annotation 3 ASN C 197
VAL C 256
HIS C 149
 None
 0.76A 6a5yD-5lwgC:
undetectable		 6a5yD-5lwgC:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlg RENIN

(Rattus
norvegicus) 		no annotation 3 ASN A  86
VAL A 147
HIS A 189
 None
 0.86A 6a5yD-5mlgA:
undetectable		 6a5yD-5mlgA:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqo NON-REDUCING END
BETA-L-ARABINOFURANO
SIDASE

(Bacteroides
thetaiotaomicron) 		PF07944
(Glyco_hydro_127) 		3 ASN A  48
VAL A 116
HIS A  45
 None
 0.81A 6a5yD-5mqoA:
undetectable		 6a5yD-5mqoA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msw THIOESTER REDUCTASE
DOMAIN-CONTAINING
PROTEIN

(Segniliparus
rugosus) 		PF00501
(AMP-binding)
PF00550
(PP-binding) 		3 ASN A 731
VAL A 720
HIS A 738
 None
 0.86A 6a5yD-5mswA:
undetectable		 6a5yD-5mswA:
5.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ndx GLYCOSYL HYDROLASE

(Rhizobium
leguminosarum) 		no annotation 3 ASN A 306
VAL A 239
HIS A 295
 None
 0.81A 6a5yD-5ndxA:
undetectable		 6a5yD-5ndxA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t2k PUTATIVE
HEME-DEPENDENT
PEROXIDASE
GT50_08830

(Geobacillus
stearothermophilus) 		PF06778
(Chlor_dismutase) 		3 ASN A 241
VAL A 248
HIS A 247
 None
 0.80A 6a5yD-5t2kA:
undetectable		 6a5yD-5t2kA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t8u LIPOATE-PROTEIN
LIGASE 1

(Plasmodium
falciparum) 		PF03099
(BPL_LplA_LipB)
PF10437
(Lip_prot_lig_C) 		3 ASN A  80
VAL A 354
HIS A 329
 None
 0.74A 6a5yD-5t8uA:
undetectable		 6a5yD-5t8uA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tzb D-AMINOPEPTIDASE

(Burkholderia
sp. LK4) 		PF03576
(Peptidase_S58) 		3 ASN A 201
VAL A 269
HIS A 172
 None
 0.80A 6a5yD-5tzbA:
undetectable		 6a5yD-5tzbA:
12.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uan RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		no annotation 3 ASN A 306
VAL A 342
HIS A 435
 None
 0.30A 6a5yD-5uanA:
34.7		 6a5yD-5uanA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vj7 OXIDOREDUCTASE

(Pyrococcus
furiosus) 		PF07992
(Pyr_redox_2)
PF14691
(Fer4_20) 		3 ASN A 303
VAL A  26
HIS A 339
 FAD  A 503 (-3.2A)
None
None
 0.75A 6a5yD-5vj7A:
undetectable		 6a5yD-5vj7A:
11.44