SIMILAR PATTERNS OF AMINO ACIDS FOR 6A5Y_D_9CRD501_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxk PROTEIN
(DTDP-GLUCOSE
4,6-DEHYDRATASE)

(Escherichia
coli) 		PF16363
(GDP_Man_Dehyd) 		5 ALA A 111
ALA A 112
LEU A  66
ALA A  67
ILE A   6
 None
 0.90A 6a5yD-1bxkA:
undetectable		 6a5yD-1bxkA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dab P.69 PERTACTIN

(Bordetella
pertussis) 		PF03212
(Pertactin) 		5 ALA A 387
ALA A 357
LEU A 383
ALA A 384
ILE A 310
 None
 0.92A 6a5yD-1dabA:
undetectable		 6a5yD-1dabA:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		5 ILE A 238
ALA A 255
ALA A 256
LEU A 100
ALA A  97
 None
 0.93A 6a5yD-1fc4A:
undetectable		 6a5yD-1fc4A:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hg4 ULTRASPIRACLE

(Drosophila
melanogaster) 		PF00104
(Hormone_recep) 		5 TRP A 318
LEU A 366
ILE A 385
CYH A 472
LEU A 476
 None
LPP  A   1 ( 4.4A)
None
LPP  A   1 ( 4.2A)
LPP  A   1 (-4.2A)
 0.74A 6a5yD-1hg4A:
25.0		 6a5yD-1hg4A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1in8 HOLLIDAY JUNCTION
DNA HELICASE RUVB

(Thermotoga
maritima) 		PF05491
(RuvB_C)
PF05496
(RuvB_N) 		5 ALA A 283
ALA A 281
LEU A 293
ALA A 290
ILE A 315
 None
 0.95A 6a5yD-1in8A:
undetectable		 6a5yD-1in8A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0h NEOPULLULANASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		5 ILE A 428
ALA A 388
LEU A 384
ILE A 455
LEU A 486
 None
 0.55A 6a5yD-1j0hA:
undetectable		 6a5yD-1j0hA:
7.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jeo HYPOTHETICAL PROTEIN
MJ1247

(Methanocaldococcus
jannaschii) 		PF01380
(SIS) 		5 ILE A  37
ALA A  40
LEU A  85
ILE A 158
LEU A 165
 None
 0.76A 6a5yD-1jeoA:
undetectable		 6a5yD-1jeoA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n60 CARBON MONOXIDE
DEHYDROGENASE SMALL
CHAIN

(Oligotropha
carboxidovorans) 		PF00111
(Fer2)
PF01799
(Fer2_2) 		5 ILE A 149
ALA A 152
ALA A 153
LEU A  90
ALA A  89
 None
 0.94A 6a5yD-1n60A:
undetectable		 6a5yD-1n60A:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nmo HYPOTHETICAL PROTEIN
YBGI

(Escherichia
coli) 		PF01784
(NIF3) 		5 ILE A 179
ALA A 182
ALA A 183
ALA A 169
ILE A 200
 None
 0.82A 6a5yD-1nmoA:
undetectable		 6a5yD-1nmoA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ALA A 350
TRP A 383
ARG A 394
ILE A 424
LEU A 525
 EST  A   1 ( 3.7A)
None
EST  A   1 (-3.7A)
EST  A   1 ( 4.5A)
EST  A   1 (-3.6A)
 0.74A 6a5yD-1pcgA:
25.5		 6a5yD-1pcgA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r20 ULTRASPIRACLE
PROTEIN

(Heliothis
virescens) 		PF00104
(Hormone_recep) 		5 TRP A 286
ARG A 297
LEU A 325
ILE A 344
LEU A 435
 None
None
None
EPH  A4000 ( 4.1A)
EPH  A4000 ( 4.6A)
 0.94A 6a5yD-1r20A:
24.6		 6a5yD-1r20A:
15.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uhl RETINOIC ACID
RECEPTOR RXR-BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 ALA A 342
ALA A 343
GLN A 346
TRP A 376
ARG A 387
ALA A 398
LEU A 526
 MEI  A1001 (-3.1A)
MEI  A1001 (-3.3A)
None
None
MEI  A1001 (-3.6A)
MEI  A1001 (-3.4A)
None
 1.31A 6a5yD-1uhlA:
35.5		 6a5yD-1uhlA:
79.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uhl RETINOIC ACID
RECEPTOR RXR-BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		12 ILE A 339
ALA A 342
ALA A 343
GLN A 346
TRP A 376
PHE A 384
ARG A 387
LEU A 397
ALA A 398
ILE A 416
CYH A 503
LEU A 507
 MEI  A1001 (-3.8A)
MEI  A1001 (-3.1A)
MEI  A1001 (-3.3A)
None
None
MEI  A1001 (-4.5A)
MEI  A1001 (-3.6A)
MEI  A1001 ( 4.4A)
MEI  A1001 (-3.4A)
None
MEI  A1001 (-4.0A)
MEI  A1001 (-4.6A)
 0.73A 6a5yD-1uhlA:
35.5		 6a5yD-1uhlA:
79.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xiu RXR-LIKE PROTEIN

(Biomphalaria
glabrata) 		PF00104
(Hormone_recep) 		10 ALA A 245
ALA A 246
GLN A 249
TRP A 279
PHE A 287
ARG A 290
LEU A 300
ALA A 301
ILE A 402
CYH A 406
 9CR  A 201 (-3.6A)
9CR  A 201 (-3.6A)
9CR  A 201 (-4.1A)
None
9CR  A 201 (-4.7A)
9CR  A 201 (-2.8A)
9CR  A 201 (-4.4A)
9CR  A 201 (-3.4A)
None
9CR  A 201 (-3.6A)
 1.48A 6a5yD-1xiuA:
32.3		 6a5yD-1xiuA:
75.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xiu RXR-LIKE PROTEIN

(Biomphalaria
glabrata) 		PF00104
(Hormone_recep) 		12 ILE A 242
ALA A 245
ALA A 246
GLN A 249
TRP A 279
PHE A 287
ARG A 290
LEU A 300
ALA A 301
ILE A 319
CYH A 406
LEU A 410
 9CR  A 201 ( 4.4A)
9CR  A 201 (-3.6A)
9CR  A 201 (-3.6A)
9CR  A 201 (-4.1A)
None
9CR  A 201 (-4.7A)
9CR  A 201 (-2.8A)
9CR  A 201 (-4.4A)
9CR  A 201 (-3.4A)
None
9CR  A 201 (-3.6A)
9CR  A 201 ( 4.8A)
 0.45A 6a5yD-1xiuA:
32.3		 6a5yD-1xiuA:
75.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xls RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 ALA A 271
ALA A 272
GLN A 275
TRP A 305
ALA A 327
LEU A 455
 9CR  A 801 (-3.6A)
9CR  A 801 (-3.5A)
9CR  A 801 (-4.7A)
None
9CR  A 801 (-3.3A)
None
 1.32A 6a5yD-1xlsA:
34.9		 6a5yD-1xlsA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xls RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		12 ILE A 268
ALA A 271
ALA A 272
GLN A 275
TRP A 305
PHE A 313
ARG A 316
LEU A 326
ALA A 327
ILE A 345
CYH A 432
LEU A 436
 9CR  A 801 (-3.9A)
9CR  A 801 (-3.6A)
9CR  A 801 (-3.5A)
9CR  A 801 (-4.7A)
None
9CR  A 801 (-4.3A)
9CR  A 801 (-2.6A)
9CR  A 801 (-4.1A)
9CR  A 801 (-3.3A)
9CR  A 801 ( 4.5A)
9CR  A 801 ( 3.7A)
9CR  A 801 (-4.7A)
 0.40A 6a5yD-1xlsA:
34.9		 6a5yD-1xlsA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xv9 ORPHAN NUCLEAR
RECEPTOR NR1I3

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ALA B 197
ALA B 198
LEU B 267
ALA B 266
LEU B 342
 None
 0.94A 6a5yD-1xv9B:
20.5		 6a5yD-1xv9B:
16.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1z5x ULTRASPIRACLE
PROTEIN (USP) A
HOMOLOGUE OF RXR

(Bemisia tabaci) 		PF00104
(Hormone_recep) 		5 ILE U 303
ALA U 306
ALA U 307
LEU U 365
ALA U 362
 None
 0.94A 6a5yD-1z5xU:
22.8		 6a5yD-1z5xU:
41.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fv2 RCD1 REQUIRED FOR
CELL
DIFFERENTIATION1
HOMOLOG

(Homo sapiens) 		PF04078
(Rcd1) 		5 ALA A  85
GLN A  82
LEU A 130
ALA A 129
LEU A  51
 None
 0.82A 6a5yD-2fv2A:
undetectable		 6a5yD-2fv2A:
17.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gl8 RETINOIC ACID
RECEPTOR RXR-GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 TRP A  84
PHE A  92
ARG A  95
LEU A 105
ALA A 106
ILE A 124
CYH A 211
 None
 0.77A 6a5yD-2gl8A:
28.3		 6a5yD-2gl8A:
77.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kyr FRUCTOSE-LIKE
PHOSPHOTRANSFERASE
ENZYME IIB COMPONENT
1

(Escherichia
coli) 		PF02302
(PTS_IIB) 		5 ALA A  21
ALA A  22
LEU A  85
ALA A  88
ILE A  46
 None
 0.97A 6a5yD-2kyrA:
undetectable		 6a5yD-2kyrA:
25.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2nxx ULTRASPIRACLE (USP,
NR2B4)

(Tribolium
castaneum) 		PF00104
(Hormone_recep) 		6 PHE A 259
ARG A 262
LEU A 272
ALA A 273
ILE A 291
CYH A 378
 None
 0.94A 6a5yD-2nxxA:
25.6		 6a5yD-2nxxA:
52.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ALA A 350
TRP A 383
ARG A 394
ILE A 424
LEU A 525
 EST  A 596 ( 3.9A)
None
EST  A 596 (-4.0A)
EST  A 596 ( 4.7A)
EST  A 596 (-3.6A)
 0.81A 6a5yD-2ocfA:
25.7		 6a5yD-2ocfA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oi2 MEVALONATE KINASE

(Streptococcus
pneumoniae) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 ILE A  79
ALA A  99
ALA A  98
LEU A  57
ALA A  60
 None
 0.95A 6a5yD-2oi2A:
undetectable		 6a5yD-2oi2A:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6w PUTATIVE
GLYCOSYLTRANSFERASE
(MANNOSYLTRANSFERASE
) INVOLVED IN
GLYCOSYLATING THE
PBCV-1 MAJOR CAPSID
PROTEIN

(Paramecium
bursaria
Chlorella virus
1) 		PF05637
(Glyco_transf_34) 		5 ILE A  61
ALA A  64
ALA A  65
LEU A   9
ILE A 132
 None
 0.87A 6a5yD-2p6wA:
undetectable		 6a5yD-2p6wA:
14.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q60 RETINOID X RECEPTOR

(Polyandrocarpa
misakiensis) 		PF00104
(Hormone_recep) 		6 TRP A 180
PHE A 188
ARG A 191
ALA A 202
ILE A 220
CYH A 307
 None
 0.65A 6a5yD-2q60A:
27.2		 6a5yD-2q60A:
54.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v84 SPERMIDINE/PUTRESCIN
E ABC TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN

(Treponema
pallidum) 		PF13416
(SBP_bac_8) 		5 ALA A 174
ALA A 175
LEU A 156
ALA A 155
ILE A 312
 None
 0.85A 6a5yD-2v84A:
undetectable		 6a5yD-2v84A:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xax RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 1
SUBUNIT ALPHA

(Escherichia
coli) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		5 ILE A  62
ALA A  66
ALA A  65
LEU A  84
ALA A  81
 None
 1.00A 6a5yD-2xaxA:
undetectable		 6a5yD-2xaxA:
7.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjn GLYCOSYLTRANSFERASE

(Saccharopolyspora
erythraea) 		PF06722
(DUF1205) 		5 ALA A 156
ALA A 157
LEU A 132
ILE A  63
LEU A  37
 None
 0.85A 6a5yD-2yjnA:
undetectable		 6a5yD-2yjnA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afg SUBTILISIN-LIKE
SERINE PROTEASE

(Thermococcus
kodakarensis) 		PF00082
(Peptidase_S8)
PF04151
(PPC) 		5 ILE A 368
ALA A 415
ALA A 416
LEU A 388
ALA A 387
 None
 0.92A 6a5yD-3afgA:
undetectable		 6a5yD-3afgA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3axy 14-3-3-LIKE PROTEIN
GF14-C

(Oryza sativa) 		PF00244
(14-3-3) 		5 ALA C 146
ALA C 145
ILE C  54
CYH C  98
LEU C 102
 None
 0.99A 6a5yD-3axyC:
undetectable		 6a5yD-3axyC:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8u PURR TRANSCRIPTIONAL
REGULATOR

(Vibrio
parahaemolyticus) 		PF13377
(Peripla_BP_3) 		5 ALA A 311
ALA A 310
LEU A  96
ALA A  95
ILE A  76
 None
 0.87A 6a5yD-3d8uA:
undetectable		 6a5yD-3d8uA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8u PURR TRANSCRIPTIONAL
REGULATOR

(Vibrio
parahaemolyticus) 		PF13377
(Peripla_BP_3) 		5 ALA A 311
ALA A 310
LEU A  96
ALA A  95
ILE A  77
 None
 0.89A 6a5yD-3d8uA:
undetectable		 6a5yD-3d8uA:
13.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		10 ALA A 271
ALA A 272
GLN A 275
TRP A 305
PHE A 313
ARG A 316
LEU A 326
ALA A 327
ILE A 428
CYH A 432
 9CR  A7223 (-3.5A)
9CR  A7223 (-4.2A)
9CR  A7223 (-4.6A)
None
9CR  A7223 (-4.5A)
9CR  A7223 (-3.7A)
9CR  A7223 (-3.8A)
9CR  A7223 ( 4.7A)
None
9CR  A7223 (-3.8A)
 1.45A 6a5yD-3dzuA:
34.1		 6a5yD-3dzuA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		12 ILE A 268
ALA A 271
ALA A 272
GLN A 275
TRP A 305
PHE A 313
ARG A 316
LEU A 326
ALA A 327
ILE A 345
CYH A 432
LEU A 436
 9CR  A7223 (-3.9A)
9CR  A7223 (-3.5A)
9CR  A7223 (-4.2A)
9CR  A7223 (-4.6A)
None
9CR  A7223 (-4.5A)
9CR  A7223 (-3.7A)
9CR  A7223 (-3.8A)
9CR  A7223 ( 4.7A)
9CR  A7223 ( 4.9A)
9CR  A7223 (-3.8A)
9CR  A7223 ( 4.7A)
 0.68A 6a5yD-3dzuA:
34.1		 6a5yD-3dzuA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fwb CELL DIVISION
CONTROL PROTEIN 31

(Saccharomyces
cerevisiae) 		PF13499
(EF-hand_7) 		5 ILE A  25
ALA A  28
LEU A  52
ALA A  51
ILE A  83
 None
 0.97A 6a5yD-3fwbA:
undetectable		 6a5yD-3fwbA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gqk PRENECK APPENDAGE
PROTEIN

(Bacillus virus
phi29) 		PF11962
(Peptidase_G2) 		5 ILE A 818
ALA A 820
LEU A 710
ALA A 721
ILE A 832
 None
 0.99A 6a5yD-3gqkA:
undetectable		 6a5yD-3gqkA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hr8 PROTEIN RECA

(Thermotoga
maritima) 		PF00154
(RecA) 		5 ALA A  85
GLN A  86
LEU A 142
ALA A  92
ILE A  49
 None
 0.98A 6a5yD-3hr8A:
undetectable		 6a5yD-3hr8A:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hve GIGAXONIN
GIGAXONIN

(Homo sapiens;
Homo sapiens) 		PF00651
(BTB)
PF07707
(BACK)
PF00651
(BTB) 		5 ILE A  47
ALA A  50
LEU B  20
ALA B  19
LEU A  87
 None
 0.70A 6a5yD-3hveA:
undetectable		 6a5yD-3hveA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hve GIGAXONIN
GIGAXONIN

(Homo sapiens;
Homo sapiens) 		PF00651
(BTB)
PF07707
(BACK)
PF00651
(BTB) 		6 ILE B  47
ALA B  50
ALA B  51
LEU A  20
ALA A  19
LEU B  87
 None
 0.91A 6a5yD-3hveB:
undetectable		 6a5yD-3hveB:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ipc ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (AMINO ACID)

(Agrobacterium
fabrum) 		PF13458
(Peripla_BP_6) 		6 ILE A 286
ALA A 289
ALA A 290
LEU A 305
ALA A 304
ILE A  94
 None
 1.39A 6a5yD-3ipcA:
undetectable		 6a5yD-3ipcA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwz CATABOLITE
ACTIVATION-LIKE
PROTEIN

(Xanthomonas
campestris) 		PF00027
(cNMP_binding)
PF00325
(Crp) 		5 ILE A 133
ALA A 136
LEU A  22
ILE A 113
LEU A  91
 None
 0.97A 6a5yD-3iwzA:
undetectable		 6a5yD-3iwzA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k11 PUTATIVE GLYCOSYL
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF07470
(Glyco_hydro_88) 		5 ILE A 228
ALA A 232
ALA A 230
GLN A 233
LEU A 164
 None
 0.94A 6a5yD-3k11A:
undetectable		 6a5yD-3k11A:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kkj AMINE OXIDASE,
FLAVIN-CONTAINING

(Pseudomonas
syringae group
genomosp. 3) 		PF01593
(Amino_oxidase)
PF13450
(NAD_binding_8) 		5 ILE A 297
ALA A 170
ALA A 169
LEU A 173
ILE A   8
 None
None
None
None
FAD  A 401 (-4.8A)
 0.99A 6a5yD-3kkjA:
undetectable		 6a5yD-3kkjA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lml LIN1278 PROTEIN

(Listeria
innocua) 		PF04984
(Phage_sheath_1)
PF17481
(Phage_sheath_1N)
PF17482
(Phage_sheath_1C) 		5 ALA A 277
ALA A 274
ALA A 279
ILE A  55
LEU A  42
 None
 0.96A 6a5yD-3lmlA:
undetectable		 6a5yD-3lmlA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lqy PUTATIVE
ISOCHORISMATASE
HYDROLASE

(Oleispira
antarctica) 		PF00857
(Isochorismatase) 		5 ALA A 146
ALA A  35
GLN A  38
ALA A 182
ILE A  77
 None
 0.99A 6a5yD-3lqyA:
undetectable		 6a5yD-3lqyA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3msu CITRATE SYNTHASE

(Francisella
tularensis) 		PF00285
(Citrate_synt) 		5 ALA A 175
ALA A 176
LEU A 388
ALA A 384
ILE A 218
 None
 0.87A 6a5yD-3msuA:
undetectable		 6a5yD-3msuA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oks 4-AMINOBUTYRATE
TRANSAMINASE

(Mycolicibacterium
smegmatis) 		PF00202
(Aminotran_3) 		5 ILE A 327
ALA A 331
ALA A 330
LEU A 298
ALA A 295
 None
 0.97A 6a5yD-3oksA:
undetectable		 6a5yD-3oksA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N

(Escherichia
coli) 		no annotation 5 ILE N 250
ALA N 249
LEU N 119
ALA N 120
LEU N 306
 None
 0.89A 6a5yD-3rkoN:
undetectable		 6a5yD-3rkoN:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rmj 2-ISOPROPYLMALATE
SYNTHASE

(Neisseria
meningitidis) 		PF00682
(HMGL-like) 		6 ILE A 156
ALA A 159
TRP A 201
PHE A 140
ALA A 163
LEU A 189
 None
 1.31A 6a5yD-3rmjA:
undetectable		 6a5yD-3rmjA:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5w L-ORNITHINE
5-MONOOXYGENASE

(Pseudomonas
aeruginosa) 		PF13434
(K_oxygenase) 		5 ILE A 419
ALA A 416
LEU A  25
ALA A  24
ILE A 376
 None
 1.00A 6a5yD-3s5wA:
undetectable		 6a5yD-3s5wA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3suc PRENECK APPENDAGE
PROTEIN

(Bacillus virus
phi29) 		PF11962
(Peptidase_G2)
PF12708
(Pectate_lyase_3) 		5 ILE A 818
ALA A 820
LEU A 710
ALA A 721
ILE A 832
 None
 0.93A 6a5yD-3sucA:
undetectable		 6a5yD-3sucA:
7.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uc2 HYPOTHETICAL PROTEIN
WITH
IMMUNOGLOBULIN-LIKE
FOLD

(Pseudomonas
aeruginosa) 		PF14467
(DUF4426) 		5 ILE A  59
ALA A 103
GLN A 104
PHE A 105
LEU A  88
 None
 0.99A 6a5yD-3uc2A:
undetectable		 6a5yD-3uc2A:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uwc NUCLEOTIDE-SUGAR
AMINOTRANSFERASE

(Coxiella
burnetii) 		PF01041
(DegT_DnrJ_EryC1) 		5 ALA A  91
LEU A  63
ALA A  64
ILE A 110
LEU A 101
 None
 0.92A 6a5yD-3uwcA:
undetectable		 6a5yD-3uwcA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7

(Caenorhabditis
elegans) 		PF13649
(Methyltransf_25) 		5 ILE A 517
ALA A 521
LEU A  28
ALA A  29
ILE A 106
 None
 0.82A 6a5yD-3wstA:
undetectable		 6a5yD-3wstA:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxw ADIPONECTIN RECEPTOR
PROTEIN 2

(Homo sapiens) 		PF03006
(HlyIII) 		5 ILE A 322
ALA A 325
ALA A 326
LEU A 283
ALA A 279
 None
 0.65A 6a5yD-3wxwA:
undetectable		 6a5yD-3wxwA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgx CHROMOSOME PARTITION
PROTEIN SMC

(Bacillus
subtilis) 		PF02463
(SMC_N) 		5 ALA A1057
ALA A1076
GLN A1077
PHE A1052
LEU A 150
 None
 0.98A 6a5yD-3zgxA:
undetectable		 6a5yD-3zgxA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zil AAR187CP

(Eremothecium
gossypii) 		PF16997
(Wap1) 		6 ILE A 359
ALA A 356
TRP A 338
LEU A 397
ALA A 393
LEU A 335
 None
 1.41A 6a5yD-3zilA:
undetectable		 6a5yD-3zilA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF16417
(CNOT1_TTP_bind)
PF16418
(CNOT1_HEAT)
PF16419
(CNOT1_HEAT_N) 		5 ILE A 741
ALA A 744
ALA A 745
LEU A 714
ALA A 715
 None
 0.79A 6a5yD-4b8bA:
undetectable		 6a5yD-4b8bA:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bmv SHORT-CHAIN
DEHYDROGENASE

(Sphingobium
yanoikuyae) 		PF00106
(adh_short) 		5 ALA A  61
GLN A  60
LEU A  41
ILE A  82
LEU A 119
 None
 0.99A 6a5yD-4bmvA:
undetectable		 6a5yD-4bmvA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgm AMINOPEPTIDASE N
FAMILY PROTEIN

(Idiomarina
loihiensis) 		PF05299
(Peptidase_M61)
PF13180
(PDZ_2) 		5 ILE A 548
ALA A 512
PHE A 487
LEU A 514
ILE A 536
 None
 0.96A 6a5yD-4fgmA:
undetectable		 6a5yD-4fgmA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hsc STREPTOLYSIN O

(Streptococcus
pyogenes) 		PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C) 		5 ILE X 557
ALA X 475
GLN X 476
TRP X 499
ILE X 568
 None
 0.97A 6a5yD-4hscX:
undetectable		 6a5yD-4hscX:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ia4 AQUAPORIN

(Spinacia
oleracea) 		PF00230
(MIP) 		5 ALA A 257
ALA A 258
GLN A 261
LEU A 110
ALA A 111
 None
 0.70A 6a5yD-4ia4A:
undetectable		 6a5yD-4ia4A:
15.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4j5x RETINOIC ACID
RECEPTOR RXR-ALPHA,
NUCLEAR RECEPTOR
COACTIVATOR 1

(Homo sapiens) 		no annotation 7 ALA D 271
ALA D 272
GLN D 275
TRP D 305
ARG D 316
ALA D 327
LEU D 455
 None
 1.28A 6a5yD-4j5xD:
33.9		 6a5yD-4j5xD:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4j5x RETINOIC ACID
RECEPTOR RXR-ALPHA,
NUCLEAR RECEPTOR
COACTIVATOR 1

(Homo sapiens) 		no annotation 12 ILE D 268
ALA D 271
ALA D 272
GLN D 275
TRP D 305
PHE D 313
ARG D 316
LEU D 326
ALA D 327
ILE D 345
CYH D 432
LEU D 436
 None
 0.57A 6a5yD-4j5xD:
33.9		 6a5yD-4j5xD:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lij FAR UPSTREAM
ELEMENT-BINDING
PROTEIN 1

(Homo sapiens) 		PF00013
(KH_1) 		5 ILE A 125
GLN A 165
ILE A 135
CYH A 147
LEU A 149
 None
 0.98A 6a5yD-4lijA:
undetectable		 6a5yD-4lijA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nn1 TRANSCRIPTIONAL
REGULATOR

(Mycobacterium
tuberculosis) 		PF00440
(TetR_N) 		5 ILE A  12
ALA A  15
ALA A  16
GLN A  19
ALA A  35
 None
 0.49A 6a5yD-4nn1A:
undetectable		 6a5yD-4nn1A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5a LACI FAMILY
TRANSCRIPTION
REGULATOR

(Bifidobacterium
animalis) 		PF13377
(Peripla_BP_3) 		6 ALA A 309
ALA A 308
GLN A 310
LEU A  96
ALA A  95
ILE A  85
 None
None
SO4  A 404 (-3.4A)
None
None
None
 1.32A 6a5yD-4o5aA:
undetectable		 6a5yD-4o5aA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5a LACI FAMILY
TRANSCRIPTION
REGULATOR

(Bifidobacterium
animalis) 		PF13377
(Peripla_BP_3) 		6 ALA A 309
ALA A 308
GLN A 310
LEU A  96
ALA A  95
LEU A 133
 None
None
SO4  A 404 (-3.4A)
None
None
None
 1.31A 6a5yD-4o5aA:
undetectable		 6a5yD-4o5aA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p47 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Ochrobactrum
anthropi) 		PF03480
(DctP) 		5 ILE A 260
ALA A 264
ALA A 263
LEU A 144
ALA A 145
 None
 0.97A 6a5yD-4p47A:
undetectable		 6a5yD-4p47A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qpn PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21B

(Homo sapiens) 		PF10294
(Methyltransf_16) 		5 ALA A 179
LEU A  63
ALA A  59
ILE A  80
LEU A 166
 None
 0.77A 6a5yD-4qpnA:
undetectable		 6a5yD-4qpnA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rrj PROBABLE
THREONINE--TRNA
LIGASE 2

(Aeropyrum
pernix) 		PF08915
(tRNA-Thr_ED) 		5 ILE A  58
ALA A  55
ALA A  54
LEU A  99
ALA A  98
 None
 0.95A 6a5yD-4rrjA:
undetectable		 6a5yD-4rrjA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uqg DNA POLYMERASE

(Geobacillus
stearothermophilus) 		PF00476
(DNA_pol_A) 		5 ILE A 804
ALA A 801
ALA A 800
GLN A 797
LEU A 862
 None
 0.96A 6a5yD-4uqgA:
undetectable		 6a5yD-4uqgA:
8.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x8f RIBOKINASE

(Vibrio cholerae) 		PF00294
(PfkB) 		6 ILE A 146
ALA A 150
ALA A 149
GLN A 151
LEU A 174
LEU A 117
 None
 1.39A 6a5yD-4x8fA:
undetectable		 6a5yD-4x8fA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ

(Escherichia
coli) 		PF00588
(SpoU_methylase) 		6 ILE A  57
ALA A  53
ALA A  22
LEU A  49
ALA A  50
LEU A   9
 None
 1.40A 6a5yD-4xboA:
undetectable		 6a5yD-4xboA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ

(Escherichia
coli) 		PF00588
(SpoU_methylase) 		6 ILE A  57
ALA A  53
ALA A  22
LEU A  49
ALA A  50
LEU A  35
 None
 1.32A 6a5yD-4xboA:
undetectable		 6a5yD-4xboA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xg0 UNCHARACTERIZED
PROTEIN

(Bordetella
bronchiseptica) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		5 ALA A 322
ALA A 321
LEU A 348
ALA A 347
ILE A 398
 None
 0.96A 6a5yD-4xg0A:
undetectable		 6a5yD-4xg0A:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgj UNCHARACTERIZED
PROTEIN

(Pectobacterium
atrosepticum) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		5 ILE A 211
ALA A 214
ALA A 215
LEU A 183
ALA A 184
 None
 0.76A 6a5yD-4xgjA:
undetectable		 6a5yD-4xgjA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yk2 BARTONELLA EFFECTOR
PROTEIN (BEP)
SUBSTRATE OF VIRB
T4SS

(Bartonella
clarridgeiae) 		no annotation 6 ILE A 160
ALA A 156
PHE A 103
LEU A 140
ALA A 141
ILE A 167
 None
 1.48A 6a5yD-4yk2A:
undetectable		 6a5yD-4yk2A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bt1 HAT1-INTERACTING
FACTOR 1

(Saccharomyces
cerevisiae) 		no annotation 6 ALA A  41
ALA A  42
LEU A  33
ALA A  29
ILE A 245
LEU A 202
 None
 0.86A 6a5yD-5bt1A:
undetectable		 6a5yD-5bt1A:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gt5 PECTATE LYASE

(Paenibacillus
sp. 0602) 		no annotation 5 ILE A 117
ALA A 116
ALA A 115
PHE A 132
LEU A  39
 None
 0.95A 6a5yD-5gt5A:
undetectable		 6a5yD-5gt5A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5izk SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR

(Homo sapiens) 		PF00009
(GTP_EFTU) 		5 ALA A 186
ALA A 185
LEU A  23
ALA A  22
ILE A 181
 GDP  A1001 ( 4.5A)
GDP  A1001 ( 4.4A)
None
GDP  A1001 (-3.8A)
None
 0.91A 6a5yD-5izkA:
undetectable		 6a5yD-5izkA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5v IMMUNITY PROTEIN
CDII

(Escherichia
coli) 		no annotation 5 ILE C  30
ALA C  46
GLN C  49
PHE C  27
LEU C  35
 None
 0.92A 6a5yD-5j5vC:
undetectable		 6a5yD-5j5vC:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		6 ILE A 910
ALA A 900
ALA A 879
PHE A 883
CYH A 946
LEU A 871
 None
 1.48A 6a5yD-5lpyA:
undetectable		 6a5yD-5lpyA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpz PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		6 ILE A 910
ALA A 900
ALA A 879
PHE A 883
CYH A 946
LEU A 871
 None
 1.47A 6a5yD-5lpzA:
undetectable		 6a5yD-5lpzA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzy GLUTACONATE
COA-TRANSFERASE
FAMILY, SUBUNIT A

(Myxococcus
xanthus) 		PF01144
(CoA_trans) 		5 ALA A 189
ALA A 190
PHE A 157
LEU A 113
ALA A 116
 None
 0.96A 6a5yD-5mzyA:
undetectable		 6a5yD-5mzyA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n0g PRECORRIN-8X
METHYLMUTASE

(Rhodobacter
capsulatus) 		no annotation 5 ILE A  73
ALA A  71
ALA A 130
LEU A  67
ALA A  66
 None
 0.91A 6a5yD-5n0gA:
undetectable		 6a5yD-5n0gA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n0g PRECORRIN-8X
METHYLMUTASE

(Rhodobacter
capsulatus) 		no annotation 5 ILE A 196
ALA A  44
ALA A  43
LEU A  49
ILE A 160
 None
None
8F5  A 301 ( 4.1A)
None
None
 0.80A 6a5yD-5n0gA:
undetectable		 6a5yD-5n0gA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nnz DYNEIN ASSEMBLY
FACTOR WITH WDR
REPEAT DOMAINS 1

(Homo sapiens) 		no annotation 6 ILE B 351
LEU B 360
ALA B 374
ILE B 306
CYH B 285
LEU B 277
 None
 1.46A 6a5yD-5nnzB:
undetectable		 6a5yD-5nnzB:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohs -

(-) 		no annotation 5 ILE A 257
ALA A 260
PHE A 541
LEU A 538
ALA A 539
 None
 0.79A 6a5yD-5ohsA:
undetectable		 6a5yD-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ALA A 302
TRP A 335
ARG A 346
ILE A 376
LEU A 476
 EST  A 601 ( 3.9A)
None
EST  A 601 (-4.1A)
EST  A 601 ( 4.4A)
EST  A 601 (-3.5A)
 0.75A 6a5yD-5toaA:
23.4		 6a5yD-5toaA:
13.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uan RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		no annotation 8 ALA A 271
ALA A 272
GLN A 275
PHE A 313
ARG A 316
LEU A 326
ALA A 327
ILE A 428
 9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.8A)
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-4.3A)
9CR  A 503 (-3.4A)
None
 1.34A 6a5yD-5uanA:
34.7		 6a5yD-5uanA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uan RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		no annotation 12 ILE A 268
ALA A 271
ALA A 272
GLN A 275
TRP A 305
PHE A 313
ARG A 316
LEU A 326
ALA A 327
ILE A 345
CYH A 432
LEU A 436
 9CR  A 503 (-4.0A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.8A)
None
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-4.3A)
9CR  A 503 (-3.4A)
None
9CR  A 503 (-3.3A)
9CR  A 503 ( 4.8A)
 0.60A 6a5yD-5uanA:
34.7		 6a5yD-5uanA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqr 2-METHYLCITRATE
SYNTHASE,
MITOCHONDRIAL

(Aspergillus
fumigatus) 		no annotation 5 ILE A 171
ALA A 175
ALA A 174
LEU A 155
LEU A 298
 None
 0.97A 6a5yD-5uqrA:
undetectable		 6a5yD-5uqrA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ve8 KAP123

(Kluyveromyces
lactis) 		no annotation 5 ILE A 302
ALA A 305
ALA A 306
LEU A 262
ALA A 265
 None
 0.94A 6a5yD-5ve8A:
undetectable		 6a5yD-5ve8A:
5.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi RIBOSOMAL PROTEIN
S19E, PUTATIVE

(Trichomonas
vaginalis) 		PF01090
(Ribosomal_S19e) 		5 ILE T  68
ALA T  65
ALA T  64
LEU T  25
ALA T  26
 None
 0.98A 6a5yD-5xyiT:
undetectable		 6a5yD-5xyiT:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d95 -

(-) 		no annotation 6 ILE A 129
ALA A 132
ALA A 133
LEU A 267
ALA A 266
ILE A 180
 None
 1.10A 6a5yD-6d95A:
undetectable		 6a5yD-6d95A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eux POLYMERASE BASIC
PROTEIN 2

(Influenza B
virus) 		no annotation 5 ILE A 312
ALA A 315
ALA A 316
LEU A 505
ILE A 273
 None
 0.82A 6a5yD-6euxA:
undetectable		 6a5yD-6euxA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5o POLYMERASE BASIC
PROTEIN 2

(Influenza B
virus) 		no annotation 5 ILE C 312
ALA C 315
ALA C 316
LEU C 505
ILE C 273
 None
 0.91A 6a5yD-6f5oC:
undetectable		 6a5yD-6f5oC:
25.58