SIMILAR PATTERNS OF AMINO ACIDS FOR 6A5Y_D_9CRD501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxk PROTEIN
(DTDP-GLUCOSE
4,6-DEHYDRATASE)

(Escherichia
coli) 		PF16363
(GDP_Man_Dehyd) 		5 ALA A 111
ALA A 112
LEU A  66
ALA A  67
ILE A   6
 None
 0.90A 6a5yD-1bxkA:
undetectable		 6a5yD-1bxkA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dab P.69 PERTACTIN

(Bordetella
pertussis) 		PF03212
(Pertactin) 		5 ALA A 387
ALA A 357
LEU A 383
ALA A 384
ILE A 310
 None
 0.92A 6a5yD-1dabA:
undetectable		 6a5yD-1dabA:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		5 ILE A 238
ALA A 255
ALA A 256
LEU A 100
ALA A  97
 None
 0.93A 6a5yD-1fc4A:
undetectable		 6a5yD-1fc4A:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hg4 ULTRASPIRACLE

(Drosophila
melanogaster) 		PF00104
(Hormone_recep) 		5 TRP A 318
LEU A 366
ILE A 385
CYH A 472
LEU A 476
 None
LPP  A   1 ( 4.4A)
None
LPP  A   1 ( 4.2A)
LPP  A   1 (-4.2A)
 0.74A 6a5yD-1hg4A:
25.0		 6a5yD-1hg4A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1in8 HOLLIDAY JUNCTION
DNA HELICASE RUVB

(Thermotoga
maritima) 		PF05491
(RuvB_C)
PF05496
(RuvB_N) 		5 ALA A 283
ALA A 281
LEU A 293
ALA A 290
ILE A 315
 None
 0.95A 6a5yD-1in8A:
undetectable		 6a5yD-1in8A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0h NEOPULLULANASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		5 ILE A 428
ALA A 388
LEU A 384
ILE A 455
LEU A 486
 None
 0.55A 6a5yD-1j0hA:
undetectable		 6a5yD-1j0hA:
7.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jeo HYPOTHETICAL PROTEIN
MJ1247

(Methanocaldococcus
jannaschii) 		PF01380
(SIS) 		5 ILE A  37
ALA A  40
LEU A  85
ILE A 158
LEU A 165
 None
 0.76A 6a5yD-1jeoA:
undetectable		 6a5yD-1jeoA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n60 CARBON MONOXIDE
DEHYDROGENASE SMALL
CHAIN

(Oligotropha
carboxidovorans) 		PF00111
(Fer2)
PF01799
(Fer2_2) 		5 ILE A 149
ALA A 152
ALA A 153
LEU A  90
ALA A  89
 None
 0.94A 6a5yD-1n60A:
undetectable		 6a5yD-1n60A:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nmo HYPOTHETICAL PROTEIN
YBGI

(Escherichia
coli) 		PF01784
(NIF3) 		5 ILE A 179
ALA A 182
ALA A 183
ALA A 169
ILE A 200
 None
 0.82A 6a5yD-1nmoA:
undetectable		 6a5yD-1nmoA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ALA A 350
TRP A 383
ARG A 394
ILE A 424
LEU A 525
 EST  A   1 ( 3.7A)
None
EST  A   1 (-3.7A)
EST  A   1 ( 4.5A)
EST  A   1 (-3.6A)
 0.74A 6a5yD-1pcgA:
25.5		 6a5yD-1pcgA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r20 ULTRASPIRACLE
PROTEIN

(Heliothis
virescens) 		PF00104
(Hormone_recep) 		5 TRP A 286
ARG A 297
LEU A 325
ILE A 344
LEU A 435
 None
None
None
EPH  A4000 ( 4.1A)
EPH  A4000 ( 4.6A)
 0.94A 6a5yD-1r20A:
24.6		 6a5yD-1r20A:
15.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uhl RETINOIC ACID
RECEPTOR RXR-BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 ALA A 342
ALA A 343
GLN A 346
TRP A 376
ARG A 387
ALA A 398
LEU A 526
 MEI  A1001 (-3.1A)
MEI  A1001 (-3.3A)
None
None
MEI  A1001 (-3.6A)
MEI  A1001 (-3.4A)
None
 1.31A 6a5yD-1uhlA:
35.5		 6a5yD-1uhlA:
79.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uhl RETINOIC ACID
RECEPTOR RXR-BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		12 ILE A 339
ALA A 342
ALA A 343
GLN A 346
TRP A 376
PHE A 384
ARG A 387
LEU A 397
ALA A 398
ILE A 416
CYH A 503
LEU A 507
 MEI  A1001 (-3.8A)
MEI  A1001 (-3.1A)
MEI  A1001 (-3.3A)
None
None
MEI  A1001 (-4.5A)
MEI  A1001 (-3.6A)
MEI  A1001 ( 4.4A)
MEI  A1001 (-3.4A)
None
MEI  A1001 (-4.0A)
MEI  A1001 (-4.6A)
 0.73A 6a5yD-1uhlA:
35.5		 6a5yD-1uhlA:
79.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xiu RXR-LIKE PROTEIN

(Biomphalaria
glabrata) 		PF00104
(Hormone_recep) 		10 ALA A 245
ALA A 246
GLN A 249
TRP A 279
PHE A 287
ARG A 290
LEU A 300
ALA A 301
ILE A 402
CYH A 406
 9CR  A 201 (-3.6A)
9CR  A 201 (-3.6A)
9CR  A 201 (-4.1A)
None
9CR  A 201 (-4.7A)
9CR  A 201 (-2.8A)
9CR  A 201 (-4.4A)
9CR  A 201 (-3.4A)
None
9CR  A 201 (-3.6A)
 1.48A 6a5yD-1xiuA:
32.3		 6a5yD-1xiuA:
75.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xiu RXR-LIKE PROTEIN

(Biomphalaria
glabrata) 		PF00104
(Hormone_recep) 		12 ILE A 242
ALA A 245
ALA A 246
GLN A 249
TRP A 279
PHE A 287
ARG A 290
LEU A 300
ALA A 301
ILE A 319
CYH A 406
LEU A 410
 9CR  A 201 ( 4.4A)
9CR  A 201 (-3.6A)
9CR  A 201 (-3.6A)
9CR  A 201 (-4.1A)
None
9CR  A 201 (-4.7A)
9CR  A 201 (-2.8A)
9CR  A 201 (-4.4A)
9CR  A 201 (-3.4A)
None
9CR  A 201 (-3.6A)
9CR  A 201 ( 4.8A)
 0.45A 6a5yD-1xiuA:
32.3		 6a5yD-1xiuA:
75.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xls RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 ALA A 271
ALA A 272
GLN A 275
TRP A 305
ALA A 327
LEU A 455
 9CR  A 801 (-3.6A)
9CR  A 801 (-3.5A)
9CR  A 801 (-4.7A)
None
9CR  A 801 (-3.3A)
None
 1.32A 6a5yD-1xlsA:
34.9		 6a5yD-1xlsA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xls RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		12 ILE A 268
ALA A 271
ALA A 272
GLN A 275
TRP A 305
PHE A 313
ARG A 316
LEU A 326
ALA A 327
ILE A 345
CYH A 432
LEU A 436
 9CR  A 801 (-3.9A)
9CR  A 801 (-3.6A)
9CR  A 801 (-3.5A)
9CR  A 801 (-4.7A)
None
9CR  A 801 (-4.3A)
9CR  A 801 (-2.6A)
9CR  A 801 (-4.1A)
9CR  A 801 (-3.3A)
9CR  A 801 ( 4.5A)
9CR  A 801 ( 3.7A)
9CR  A 801 (-4.7A)
 0.40A 6a5yD-1xlsA:
34.9		 6a5yD-1xlsA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xv9 ORPHAN NUCLEAR
RECEPTOR NR1I3

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ALA B 197
ALA B 198
LEU B 267
ALA B 266
LEU B 342
 None
 0.94A 6a5yD-1xv9B:
20.5		 6a5yD-1xv9B:
16.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1z5x ULTRASPIRACLE
PROTEIN (USP) A
HOMOLOGUE OF RXR

(Bemisia tabaci) 		PF00104
(Hormone_recep) 		5 ILE U 303
ALA U 306
ALA U 307
LEU U 365
ALA U 362
 None
 0.94A 6a5yD-1z5xU:
22.8		 6a5yD-1z5xU:
41.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fv2 RCD1 REQUIRED FOR
CELL
DIFFERENTIATION1
HOMOLOG

(Homo sapiens) 		PF04078
(Rcd1) 		5 ALA A  85
GLN A  82
LEU A 130
ALA A 129
LEU A  51
 None
 0.82A 6a5yD-2fv2A:
undetectable		 6a5yD-2fv2A:
17.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gl8 RETINOIC ACID
RECEPTOR RXR-GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 TRP A  84
PHE A  92
ARG A  95
LEU A 105
ALA A 106
ILE A 124
CYH A 211
 None
 0.77A 6a5yD-2gl8A:
28.3		 6a5yD-2gl8A:
77.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kyr FRUCTOSE-LIKE
PHOSPHOTRANSFERASE
ENZYME IIB COMPONENT
1

(Escherichia
coli) 		PF02302
(PTS_IIB) 		5 ALA A  21
ALA A  22
LEU A  85
ALA A  88
ILE A  46
 None
 0.97A 6a5yD-2kyrA:
undetectable		 6a5yD-2kyrA:
25.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2nxx ULTRASPIRACLE (USP,
NR2B4)

(Tribolium
castaneum) 		PF00104
(Hormone_recep) 		6 PHE A 259
ARG A 262
LEU A 272
ALA A 273
ILE A 291
CYH A 378
 None
 0.94A 6a5yD-2nxxA:
25.6		 6a5yD-2nxxA:
52.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ALA A 350
TRP A 383
ARG A 394
ILE A 424
LEU A 525
 EST  A 596 ( 3.9A)
None
EST  A 596 (-4.0A)
EST  A 596 ( 4.7A)
EST  A 596 (-3.6A)
 0.81A 6a5yD-2ocfA:
25.7		 6a5yD-2ocfA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oi2 MEVALONATE KINASE

(Streptococcus
pneumoniae) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 ILE A  79
ALA A  99
ALA A  98
LEU A  57
ALA A  60
 None
 0.95A 6a5yD-2oi2A:
undetectable		 6a5yD-2oi2A:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6w PUTATIVE
GLYCOSYLTRANSFERASE
(MANNOSYLTRANSFERASE
) INVOLVED IN
GLYCOSYLATING THE
PBCV-1 MAJOR CAPSID
PROTEIN

(Paramecium
bursaria
Chlorella virus
1) 		PF05637
(Glyco_transf_34) 		5 ILE A  61
ALA A  64
ALA A  65
LEU A   9
ILE A 132
 None
 0.87A 6a5yD-2p6wA:
undetectable		 6a5yD-2p6wA:
14.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q60 RETINOID X RECEPTOR

(Polyandrocarpa
misakiensis) 		PF00104
(Hormone_recep) 		6 TRP A 180
PHE A 188
ARG A 191
ALA A 202
ILE A 220
CYH A 307
 None
 0.65A 6a5yD-2q60A:
27.2		 6a5yD-2q60A:
54.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v84 SPERMIDINE/PUTRESCIN
E ABC TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN

(Treponema
pallidum) 		PF13416
(SBP_bac_8) 		5 ALA A 174
ALA A 175
LEU A 156
ALA A 155
ILE A 312
 None
 0.85A 6a5yD-2v84A:
undetectable		 6a5yD-2v84A:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xax RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 1
SUBUNIT ALPHA

(Escherichia
coli) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		5 ILE A  62
ALA A  66
ALA A  65
LEU A  84
ALA A  81
 None
 1.00A 6a5yD-2xaxA:
undetectable		 6a5yD-2xaxA:
7.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjn GLYCOSYLTRANSFERASE

(Saccharopolyspora
erythraea) 		PF06722
(DUF1205) 		5 ALA A 156
ALA A 157
LEU A 132
ILE A  63
LEU A  37
 None
 0.85A 6a5yD-2yjnA:
undetectable		 6a5yD-2yjnA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afg SUBTILISIN-LIKE
SERINE PROTEASE

(Thermococcus
kodakarensis) 		PF00082
(Peptidase_S8)
PF04151
(PPC) 		5 ILE A 368
ALA A 415
ALA A 416
LEU A 388
ALA A 387
 None
 0.92A 6a5yD-3afgA:
undetectable		 6a5yD-3afgA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3axy 14-3-3-LIKE PROTEIN
GF14-C

(Oryza sativa) 		PF00244
(14-3-3) 		5 ALA C 146
ALA C 145
ILE C  54
CYH C  98
LEU C 102
 None
 0.99A 6a5yD-3axyC:
undetectable		 6a5yD-3axyC:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8u PURR TRANSCRIPTIONAL
REGULATOR

(Vibrio
parahaemolyticus) 		PF13377
(Peripla_BP_3) 		5 ALA A 311
ALA A 310
LEU A  96
ALA A  95
ILE A  76
 None
 0.87A 6a5yD-3d8uA:
undetectable		 6a5yD-3d8uA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8u PURR TRANSCRIPTIONAL
REGULATOR

(Vibrio
parahaemolyticus) 		PF13377
(Peripla_BP_3) 		5 ALA A 311
ALA A 310
LEU A  96
ALA A  95
ILE A  77
 None
 0.89A 6a5yD-3d8uA:
undetectable		 6a5yD-3d8uA:
13.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		10 ALA A 271
ALA A 272
GLN A 275
TRP A 305
PHE A 313
ARG A 316
LEU A 326
ALA A 327
ILE A 428
CYH A 432
 9CR  A7223 (-3.5A)
9CR  A7223 (-4.2A)
9CR  A7223 (-4.6A)
None
9CR  A7223 (-4.5A)
9CR  A7223 (-3.7A)
9CR  A7223 (-3.8A)
9CR  A7223 ( 4.7A)
None
9CR  A7223 (-3.8A)
 1.45A 6a5yD-3dzuA:
34.1		 6a5yD-3dzuA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		12 ILE A 268
ALA A 271
ALA A 272
GLN A 275
TRP A 305
PHE A 313
ARG A 316
LEU A 326
ALA A 327
ILE A 345
CYH A 432
LEU A 436
 9CR  A7223 (-3.9A)
9CR  A7223 (-3.5A)
9CR  A7223 (-4.2A)
9CR  A7223 (-4.6A)
None
9CR  A7223 (-4.5A)
9CR  A7223 (-3.7A)
9CR  A7223 (-3.8A)
9CR  A7223 ( 4.7A)
9CR  A7223 ( 4.9A)
9CR  A7223 (-3.8A)
9CR  A7223 ( 4.7A)
 0.68A 6a5yD-3dzuA:
34.1		 6a5yD-3dzuA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fwb CELL DIVISION
CONTROL PROTEIN 31

(Saccharomyces
cerevisiae) 		PF13499
(EF-hand_7) 		5 ILE A  25
ALA A  28
LEU A  52
ALA A  51
ILE A  83
 None
 0.97A 6a5yD-3fwbA:
undetectable		 6a5yD-3fwbA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gqk PRENECK APPENDAGE
PROTEIN

(Bacillus virus
phi29) 		PF11962
(Peptidase_G2) 		5 ILE A 818
ALA A 820
LEU A 710
ALA A 721
ILE A 832
 None
 0.99A 6a5yD-3gqkA:
undetectable		 6a5yD-3gqkA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hr8 PROTEIN RECA

(Thermotoga
maritima) 		PF00154
(RecA) 		5 ALA A  85
GLN A  86
LEU A 142
ALA A  92
ILE A  49
 None
 0.98A 6a5yD-3hr8A:
undetectable		 6a5yD-3hr8A:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hve GIGAXONIN
GIGAXONIN

(Homo sapiens;
Homo sapiens) 		PF00651
(BTB)
PF07707
(BACK)
PF00651
(BTB) 		5 ILE A  47
ALA A  50
LEU B  20
ALA B  19
LEU A  87
 None
 0.70A 6a5yD-3hveA:
undetectable		 6a5yD-3hveA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hve GIGAXONIN
GIGAXONIN

(Homo sapiens;
Homo sapiens) 		PF00651
(BTB)
PF07707
(BACK)
PF00651
(BTB) 		6 ILE B  47
ALA B  50
ALA B  51
LEU A  20
ALA A  19
LEU B  87
 None
 0.91A 6a5yD-3hveB:
undetectable		 6a5yD-3hveB:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ipc ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (AMINO ACID)

(Agrobacterium
fabrum) 		PF13458
(Peripla_BP_6) 		6 ILE A 286
ALA A 289
ALA A 290
LEU A 305
ALA A 304
ILE A  94
 None
 1.39A 6a5yD-3ipcA:
undetectable		 6a5yD-3ipcA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwz CATABOLITE
ACTIVATION-LIKE
PROTEIN

(Xanthomonas
campestris) 		PF00027
(cNMP_binding)
PF00325
(Crp) 		5 ILE A 133
ALA A 136
LEU A  22
ILE A 113
LEU A  91
 None
 0.97A 6a5yD-3iwzA:
undetectable		 6a5yD-3iwzA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k11 PUTATIVE GLYCOSYL
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF07470
(Glyco_hydro_88) 		5 ILE A 228
ALA A 232
ALA A 230
GLN A 233
LEU A 164
 None
 0.94A 6a5yD-3k11A:
undetectable		 6a5yD-3k11A:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kkj AMINE OXIDASE,
FLAVIN-CONTAINING

(Pseudomonas
syringae group
genomosp. 3) 		PF01593
(Amino_oxidase)
PF13450
(NAD_binding_8) 		5 ILE A 297
ALA A 170
ALA A 169
LEU A 173
ILE A   8
 None
None
None
None
FAD  A 401 (-4.8A)
 0.99A 6a5yD-3kkjA:
undetectable		 6a5yD-3kkjA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lml LIN1278 PROTEIN

(Listeria
innocua) 		PF04984
(Phage_sheath_1)
PF17481
(Phage_sheath_1N)
PF17482
(Phage_sheath_1C) 		5 ALA A 277
ALA A 274
ALA A 279
ILE A  55
LEU A  42
 None
 0.96A 6a5yD-3lmlA:
undetectable		 6a5yD-3lmlA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lqy PUTATIVE
ISOCHORISMATASE
HYDROLASE

(Oleispira
antarctica) 		PF00857
(Isochorismatase) 		5 ALA A 146
ALA A  35
GLN A  38
ALA A 182
ILE A  77
 None
 0.99A 6a5yD-3lqyA:
undetectable		 6a5yD-3lqyA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3msu CITRATE SYNTHASE

(Francisella
tularensis) 		PF00285
(Citrate_synt) 		5 ALA A 175
ALA A 176
LEU A 388
ALA A 384
ILE A 218
 None
 0.87A 6a5yD-3msuA:
undetectable		 6a5yD-3msuA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oks 4-AMINOBUTYRATE
TRANSAMINASE

(Mycolicibacterium
smegmatis) 		PF00202
(Aminotran_3) 		5 ILE A 327
ALA A 331
ALA A 330
LEU A 298
ALA A 295
 None
 0.97A 6a5yD-3oksA:
undetectable		 6a5yD-3oksA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N

(Escherichia
coli) 		no annotation 5 ILE N 250
ALA N 249
LEU N 119
ALA N 120
LEU N 306
 None
 0.89A 6a5yD-3rkoN:
undetectable		 6a5yD-3rkoN:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rmj 2-ISOPROPYLMALATE
SYNTHASE

(Neisseria
meningitidis) 		PF00682
(HMGL-like) 		6 ILE A 156
ALA A 159
TRP A 201
PHE A 140
ALA A 163
LEU A 189
 None
 1.31A 6a5yD-3rmjA:
undetectable		 6a5yD-3rmjA:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5w L-ORNITHINE
5-MONOOXYGENASE

(Pseudomonas
aeruginosa) 		PF13434
(K_oxygenase) 		5 ILE A 419
ALA A 416
LEU A  25
ALA A  24
ILE A 376
 None
 1.00A 6a5yD-3s5wA:
undetectable		 6a5yD-3s5wA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3suc PRENECK APPENDAGE
PROTEIN

(Bacillus virus
phi29) 		PF11962
(Peptidase_G2)
PF12708
(Pectate_lyase_3) 		5 ILE A 818
ALA A 820
LEU A 710
ALA A 721
ILE A 832
 None
 0.93A 6a5yD-3sucA:
undetectable		 6a5yD-3sucA:
7.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uc2 HYPOTHETICAL PROTEIN
WITH
IMMUNOGLOBULIN-LIKE
FOLD

(Pseudomonas
aeruginosa) 		PF14467
(DUF4426) 		5 ILE A  59
ALA A 103
GLN A 104
PHE A 105
LEU A  88
 None
 0.99A 6a5yD-3uc2A:
undetectable		 6a5yD-3uc2A:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uwc NUCLEOTIDE-SUGAR
AMINOTRANSFERASE

(Coxiella
burnetii) 		PF01041
(DegT_DnrJ_EryC1) 		5 ALA A  91
LEU A  63
ALA A  64
ILE A 110
LEU A 101
 None
 0.92A 6a5yD-3uwcA:
undetectable		 6a5yD-3uwcA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7

(Caenorhabditis
elegans) 		PF13649
(Methyltransf_25) 		5 ILE A 517
ALA A 521
LEU A  28
ALA A  29
ILE A 106
 None
 0.82A 6a5yD-3wstA:
undetectable		 6a5yD-3wstA:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxw ADIPONECTIN RECEPTOR
PROTEIN 2

(Homo sapiens) 		PF03006
(HlyIII) 		5 ILE A 322
ALA A 325
ALA A 326
LEU A 283
ALA A 279
 None
 0.65A 6a5yD-3wxwA:
undetectable		 6a5yD-3wxwA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgx CHROMOSOME PARTITION
PROTEIN SMC

(Bacillus
subtilis) 		PF02463
(SMC_N) 		5 ALA A1057
ALA A1076
GLN A1077
PHE A1052
LEU A 150
 None
 0.98A 6a5yD-3zgxA:
undetectable		 6a5yD-3zgxA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zil AAR187CP

(Eremothecium
gossypii) 		PF16997
(Wap1) 		6 ILE A 359
ALA A 356
TRP A 338
LEU A 397
ALA A 393
LEU A 335
 None
 1.41A 6a5yD-3zilA:
undetectable		 6a5yD-3zilA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF16417
(CNOT1_TTP_bind)
PF16418
(CNOT1_HEAT)
PF16419
(CNOT1_HEAT_N) 		5 ILE A 741
ALA A 744
ALA A 745
LEU A 714
ALA A 715
 None
 0.79A 6a5yD-4b8bA:
undetectable		 6a5yD-4b8bA:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bmv SHORT-CHAIN
DEHYDROGENASE

(Sphingobium
yanoikuyae) 		PF00106
(adh_short) 		5 ALA A  61
GLN A  60
LEU A  41
ILE A  82
LEU A 119
 None
 0.99A 6a5yD-4bmvA:
undetectable		 6a5yD-4bmvA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgm AMINOPEPTIDASE N
FAMILY PROTEIN

(Idiomarina
loihiensis) 		PF05299
(Peptidase_M61)
PF13180
(PDZ_2) 		5 ILE A 548
ALA A 512
PHE A 487
LEU A 514
ILE A 536
 None
 0.96A 6a5yD-4fgmA:
undetectable		 6a5yD-4fgmA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hsc STREPTOLYSIN O

(Streptococcus
pyogenes) 		PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C) 		5 ILE X 557
ALA X 475
GLN X 476
TRP X 499
ILE X 568
 None
 0.97A 6a5yD-4hscX:
undetectable		 6a5yD-4hscX:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ia4 AQUAPORIN

(Spinacia
oleracea) 		PF00230
(MIP) 		5 ALA A 257
ALA A 258
GLN A 261
LEU A 110
ALA A 111
 None
 0.70A 6a5yD-4ia4A:
undetectable		 6a5yD-4ia4A:
15.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4j5x RETINOIC ACID
RECEPTOR RXR-ALPHA,
NUCLEAR RECEPTOR
COACTIVATOR 1

(Homo sapiens) 		no annotation 7 ALA D 271
ALA D 272
GLN D 275
TRP D 305
ARG D 316
ALA D 327
LEU D 455
 None
 1.28A 6a5yD-4j5xD:
33.9		 6a5yD-4j5xD:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4j5x RETINOIC ACID
RECEPTOR RXR-ALPHA,
NUCLEAR RECEPTOR
COACTIVATOR 1

(Homo sapiens) 		no annotation 12 ILE D 268
ALA D 271
ALA D 272
GLN D 275
TRP D 305
PHE D 313
ARG D 316
LEU D 326
ALA D 327
ILE D 345
CYH D 432
LEU D 436
 None
 0.57A 6a5yD-4j5xD:
33.9		 6a5yD-4j5xD:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lij FAR UPSTREAM
ELEMENT-BINDING
PROTEIN 1

(Homo sapiens) 		PF00013
(KH_1) 		5 ILE A 125
GLN A 165
ILE A 135
CYH A 147
LEU A 149
 None
 0.98A 6a5yD-4lijA:
undetectable		 6a5yD-4lijA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nn1 TRANSCRIPTIONAL
REGULATOR

(Mycobacterium
tuberculosis) 		PF00440
(TetR_N) 		5 ILE A  12
ALA A  15
ALA A  16
GLN A  19
ALA A  35
 None
 0.49A 6a5yD-4nn1A:
undetectable		 6a5yD-4nn1A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5a LACI FAMILY
TRANSCRIPTION
REGULATOR

(Bifidobacterium
animalis) 		PF13377
(Peripla_BP_3) 		6 ALA A 309
ALA A 308
GLN A 310
LEU A  96
ALA A  95
ILE A  85
 None
None
SO4  A 404 (-3.4A)
None
None
None
 1.32A 6a5yD-4o5aA:
undetectable		 6a5yD-4o5aA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5a LACI FAMILY
TRANSCRIPTION
REGULATOR

(Bifidobacterium
animalis) 		PF13377
(Peripla_BP_3) 		6 ALA A 309
ALA A 308
GLN A 310
LEU A  96
ALA A  95
LEU A 133
 None
None
SO4  A 404 (-3.4A)
None
None
None
 1.31A 6a5yD-4o5aA:
undetectable		 6a5yD-4o5aA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p47 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Ochrobactrum
anthropi) 		PF03480
(DctP) 		5 ILE A 260
ALA A 264
ALA A 263
LEU A 144
ALA A 145
 None
 0.97A 6a5yD-4p47A:
undetectable		 6a5yD-4p47A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qpn PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21B

(Homo sapiens) 		PF10294
(Methyltransf_16) 		5 ALA A 179
LEU A  63
ALA A  59
ILE A  80
LEU A 166
 None
 0.77A 6a5yD-4qpnA:
undetectable		 6a5yD-4qpnA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rrj PROBABLE
THREONINE--TRNA
LIGASE 2

(Aeropyrum
pernix) 		PF08915
(tRNA-Thr_ED) 		5 ILE A  58
ALA A  55
ALA A  54
LEU A  99
ALA A  98
 None
 0.95A 6a5yD-4rrjA:
undetectable		 6a5yD-4rrjA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uqg DNA POLYMERASE

(Geobacillus
stearothermophilus) 		PF00476
(DNA_pol_A) 		5 ILE A 804
ALA A 801
ALA A 800
GLN A 797
LEU A 862
 None
 0.96A 6a5yD-4uqgA:
undetectable		 6a5yD-4uqgA:
8.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x8f RIBOKINASE

(Vibrio cholerae) 		PF00294
(PfkB) 		6 ILE A 146
ALA A 150
ALA A 149
GLN A 151
LEU A 174
LEU A 117
 None
 1.39A 6a5yD-4x8fA:
undetectable		 6a5yD-4x8fA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ

(Escherichia
coli) 		PF00588
(SpoU_methylase) 		6 ILE A  57
ALA A  53
ALA A  22
LEU A  49
ALA A  50
LEU A   9
 None
 1.40A 6a5yD-4xboA:
undetectable		 6a5yD-4xboA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ

(Escherichia
coli) 		PF00588
(SpoU_methylase) 		6 ILE A  57
ALA A  53
ALA A  22
LEU A  49
ALA A  50
LEU A  35
 None
 1.32A 6a5yD-4xboA:
undetectable		 6a5yD-4xboA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xg0 UNCHARACTERIZED
PROTEIN

(Bordetella
bronchiseptica) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		5 ALA A 322
ALA A 321
LEU A 348
ALA A 347
ILE A 398
 None
 0.96A 6a5yD-4xg0A:
undetectable		 6a5yD-4xg0A:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgj UNCHARACTERIZED
PROTEIN

(Pectobacterium
atrosepticum) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		5 ILE A 211
ALA A 214
ALA A 215
LEU A 183
ALA A 184
 None
 0.76A 6a5yD-4xgjA:
undetectable		 6a5yD-4xgjA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yk2 BARTONELLA EFFECTOR
PROTEIN (BEP)
SUBSTRATE OF VIRB
T4SS

(Bartonella
clarridgeiae) 		no annotation 6 ILE A 160
ALA A 156
PHE A 103
LEU A 140
ALA A 141
ILE A 167
 None
 1.48A 6a5yD-4yk2A:
undetectable		 6a5yD-4yk2A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bt1 HAT1-INTERACTING
FACTOR 1

(Saccharomyces
cerevisiae) 		no annotation 6 ALA A  41
ALA A  42
LEU A  33
ALA A  29
ILE A 245
LEU A 202
 None
 0.86A 6a5yD-5bt1A:
undetectable		 6a5yD-5bt1A:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gt5 PECTATE LYASE

(Paenibacillus
sp. 0602) 		no annotation 5 ILE A 117
ALA A 116
ALA A 115
PHE A 132
LEU A  39
 None
 0.95A 6a5yD-5gt5A:
undetectable		 6a5yD-5gt5A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5izk SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR

(Homo sapiens) 		PF00009
(GTP_EFTU) 		5 ALA A 186
ALA A 185
LEU A  23
ALA A  22
ILE A 181
 GDP  A1001 ( 4.5A)
GDP  A1001 ( 4.4A)
None
GDP  A1001 (-3.8A)
None
 0.91A 6a5yD-5izkA:
undetectable		 6a5yD-5izkA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5v IMMUNITY PROTEIN
CDII

(Escherichia
coli) 		no annotation 5 ILE C  30
ALA C  46
GLN C  49
PHE C  27
LEU C  35
 None
 0.92A 6a5yD-5j5vC:
undetectable		 6a5yD-5j5vC:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		6 ILE A 910
ALA A 900
ALA A 879
PHE A 883
CYH A 946
LEU A 871
 None
 1.48A 6a5yD-5lpyA:
undetectable		 6a5yD-5lpyA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpz PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		6 ILE A 910
ALA A 900
ALA A 879
PHE A 883
CYH A 946
LEU A 871
 None
 1.47A 6a5yD-5lpzA:
undetectable		 6a5yD-5lpzA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzy GLUTACONATE
COA-TRANSFERASE
FAMILY, SUBUNIT A

(Myxococcus
xanthus) 		PF01144
(CoA_trans) 		5 ALA A 189
ALA A 190
PHE A 157
LEU A 113
ALA A 116
 None
 0.96A 6a5yD-5mzyA:
undetectable		 6a5yD-5mzyA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n0g PRECORRIN-8X
METHYLMUTASE

(Rhodobacter
capsulatus) 		no annotation 5 ILE A  73
ALA A  71
ALA A 130
LEU A  67
ALA A  66
 None
 0.91A 6a5yD-5n0gA:
undetectable		 6a5yD-5n0gA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n0g PRECORRIN-8X
METHYLMUTASE

(Rhodobacter
capsulatus) 		no annotation 5 ILE A 196
ALA A  44
ALA A  43
LEU A  49
ILE A 160
 None
None
8F5  A 301 ( 4.1A)
None
None
 0.80A 6a5yD-5n0gA:
undetectable		 6a5yD-5n0gA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nnz DYNEIN ASSEMBLY
FACTOR WITH WDR
REPEAT DOMAINS 1

(Homo sapiens) 		no annotation 6 ILE B 351
LEU B 360
ALA B 374
ILE B 306
CYH B 285
LEU B 277
 None
 1.46A 6a5yD-5nnzB:
undetectable		 6a5yD-5nnzB:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohs -

(-) 		no annotation 5 ILE A 257
ALA A 260
PHE A 541
LEU A 538
ALA A 539
 None
 0.79A 6a5yD-5ohsA:
undetectable		 6a5yD-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ALA A 302
TRP A 335
ARG A 346
ILE A 376
LEU A 476
 EST  A 601 ( 3.9A)
None
EST  A 601 (-4.1A)
EST  A 601 ( 4.4A)
EST  A 601 (-3.5A)
 0.75A 6a5yD-5toaA:
23.4		 6a5yD-5toaA:
13.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uan RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		no annotation 8 ALA A 271
ALA A 272
GLN A 275
PHE A 313
ARG A 316
LEU A 326
ALA A 327
ILE A 428
 9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.8A)
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-4.3A)
9CR  A 503 (-3.4A)
None
 1.34A 6a5yD-5uanA:
34.7		 6a5yD-5uanA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uan RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		no annotation 12 ILE A 268
ALA A 271
ALA A 272
GLN A 275
TRP A 305
PHE A 313
ARG A 316
LEU A 326
ALA A 327
ILE A 345
CYH A 432
LEU A 436
 9CR  A 503 (-4.0A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.8A)
None
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-4.3A)
9CR  A 503 (-3.4A)
None
9CR  A 503 (-3.3A)
9CR  A 503 ( 4.8A)
 0.60A 6a5yD-5uanA:
34.7		 6a5yD-5uanA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqr 2-METHYLCITRATE
SYNTHASE,
MITOCHONDRIAL

(Aspergillus
fumigatus) 		no annotation 5 ILE A 171
ALA A 175
ALA A 174
LEU A 155
LEU A 298
 None
 0.97A 6a5yD-5uqrA:
undetectable		 6a5yD-5uqrA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ve8 KAP123

(Kluyveromyces
lactis) 		no annotation 5 ILE A 302
ALA A 305
ALA A 306
LEU A 262
ALA A 265
 None
 0.94A 6a5yD-5ve8A:
undetectable		 6a5yD-5ve8A:
5.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi RIBOSOMAL PROTEIN
S19E, PUTATIVE

(Trichomonas
vaginalis) 		PF01090
(Ribosomal_S19e) 		5 ILE T  68
ALA T  65
ALA T  64
LEU T  25
ALA T  26
 None
 0.98A 6a5yD-5xyiT:
undetectable		 6a5yD-5xyiT:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d95 -

(-) 		no annotation 6 ILE A 129
ALA A 132
ALA A 133
LEU A 267
ALA A 266
ILE A 180
 None
 1.10A 6a5yD-6d95A:
undetectable		 6a5yD-6d95A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eux POLYMERASE BASIC
PROTEIN 2

(Influenza B
virus) 		no annotation 5 ILE A 312
ALA A 315
ALA A 316
LEU A 505
ILE A 273
 None
 0.82A 6a5yD-6euxA:
undetectable		 6a5yD-6euxA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5o POLYMERASE BASIC
PROTEIN 2

(Influenza B
virus) 		no annotation 5 ILE C 312
ALA C 315
ALA C 316
LEU C 505
ILE C 273
 None
 0.91A 6a5yD-6f5oC:
undetectable		 6a5yD-6f5oC:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bvs PROTEIN (HOLLIDAY
JUNCTION DNA
HELICASE RUVA)

(Mycobacterium
leprae) 		PF01330
(RuvA_N)
PF07499
(RuvA_C)
PF14520
(HHH_5) 		3 ASN A  67
VAL A 112
HIS A  92
 None
 0.82A 6a5yD-1bvsA:
undetectable		 6a5yD-1bvsA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gvh FLAVOHEMOPROTEIN

(Escherichia
coli) 		PF00042
(Globin)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		3 ASN A 238
VAL A 221
HIS A 234
 None
FAD  A1397 (-3.5A)
None
 0.47A 6a5yD-1gvhA:
0.4		 6a5yD-1gvhA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ir6 EXONUCLEASE RECJ

(Thermus
thermophilus) 		PF01368
(DHH)
PF02272
(DHHA1) 		3 ASN A 151
VAL A 117
HIS A 125
 None
 0.72A 6a5yD-1ir6A:
undetectable		 6a5yD-1ir6A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jv1 GLCNAC1P
URIDYLTRANSFERASE
ISOFORM 1: AGX1

(Homo sapiens) 		PF01704
(UDPGP) 		3 ASN A 254
VAL A 382
HIS A 331
 None
 0.84A 6a5yD-1jv1A:
undetectable		 6a5yD-1jv1A:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kug METALLOPROTEINASE

(Protobothrops
mucrosquamatus) 		PF01421
(Reprolysin) 		3 ASN A 104
VAL A 138
HIS A 131
 None
None
CD  A 988 (-3.3A)
 0.86A 6a5yD-1kugA:
0.0		 6a5yD-1kugA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE

(Saccharomyces
cerevisiae) 		PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5) 		3 ASN A 501
VAL A 396
HIS A 398
 None
 0.84A 6a5yD-1la2A:
undetectable		 6a5yD-1la2A:
8.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lox 15-LIPOXYGENASE

(Oryctolagus
cuniculus) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		3 ASN A 152
VAL A 661
HIS A 366
 None
None
FE2  A 840 (-3.4A)
 0.74A 6a5yD-1loxA:
2.0		 6a5yD-1loxA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r53 CHORISMATE SYNTHASE

(Saccharomyces
cerevisiae) 		PF01264
(Chorismate_synt) 		3 ASN A 289
VAL A 266
HIS A 271
 None
 0.74A 6a5yD-1r53A:
0.0		 6a5yD-1r53A:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1smr RENIN

(Mus musculus) 		PF00026
(Asp) 		3 ASN A  37
VAL A  96
HIS A 139
 None
 0.84A 6a5yD-1smrA:
undetectable		 6a5yD-1smrA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tlt PUTATIVE
OXIDOREDUCTASE
(VIRULENCE FACTOR
MVIM HOMOLOG)

(Escherichia
coli) 		PF01408
(GFO_IDH_MocA) 		3 ASN A 101
VAL A  94
HIS A  78
 None
 0.51A 6a5yD-1tltA:
undetectable		 6a5yD-1tltA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txk GLUCANS BIOSYNTHESIS
PROTEIN G

(Escherichia
coli) 		PF04349
(MdoG) 		3 ASN A  65
VAL A 118
HIS A 120
 None
 0.81A 6a5yD-1txkA:
undetectable		 6a5yD-1txkA:
9.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uhl RETINOIC ACID
RECEPTOR RXR-BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		3 ASN A 377
VAL A 413
HIS A 506
 None
MEI  A1001 (-4.1A)
None
 0.67A 6a5yD-1uhlA:
35.5		 6a5yD-1uhlA:
79.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uxe FIBER PROTEIN

(Human
mastadenovirus
D) 		PF00541
(Adeno_knob) 		3 ASN A 234
VAL A 225
HIS A 231
 None
None
ZN  A1366 ( 3.2A)
 0.87A 6a5yD-1uxeA:
undetectable		 6a5yD-1uxeA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1

(Pyrococcus
furiosus) 		PF00291
(PALP) 		3 ASN B 369
VAL B 322
HIS B 348
 None
 0.82A 6a5yD-1wdwB:
undetectable		 6a5yD-1wdwB:
10.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xiu RXR-LIKE PROTEIN

(Biomphalaria
glabrata) 		PF00104
(Hormone_recep) 		3 ASN A 280
VAL A 316
HIS A 409
 None
9CR  A 201 (-4.2A)
9CR  A 201 (-4.8A)
 0.33A 6a5yD-1xiuA:
32.3		 6a5yD-1xiuA:
75.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xls RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		3 ASN A 306
VAL A 342
HIS A 435
 None
9CR  A 801 ( 4.3A)
None
 0.24A 6a5yD-1xlsA:
34.9		 6a5yD-1xlsA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xuq SUPEROXIDE DISMUTASE

(Bacillus
anthracis) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		3 ASN A  34
VAL A  55
HIS A   4
 None
 0.83A 6a5yD-1xuqA:
undetectable		 6a5yD-1xuqA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yac YCAC GENE PRODUCT

(Escherichia
coli) 		PF00857
(Isochorismatase) 		3 ASN A  38
VAL A 113
HIS A  20
 None
 0.85A 6a5yD-1yacA:
undetectable		 6a5yD-1yacA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c81 GLUTAMINE-2-DEOXY-SC
YLLO-INOSOSE
AMINOTRANSFERASE

(Bacillus
circulans) 		PF01041
(DegT_DnrJ_EryC1) 		3 ASN A 275
VAL A 193
HIS A 390
 None
 0.76A 6a5yD-2c81A:
undetectable		 6a5yD-2c81A:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1u IRON(III) DICITRATE
TRANSPORT PROTEIN
FECA

(Escherichia
coli) 		PF07660
(STN) 		3 ASN A  15
VAL A  46
HIS A  20
 None
 0.75A 6a5yD-2d1uA:
undetectable		 6a5yD-2d1uA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7s RNA-DEPENDENT RNA
POLYMERASE

(Foot-and-mouth
disease virus) 		PF00680
(RdRP_1) 		3 ASN A 206
VAL A 260
HIS A  86
 None
 0.74A 6a5yD-2d7sA:
undetectable		 6a5yD-2d7sA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d9v PLECKSTRIN HOMOLOGY
DOMAIN-CONTAINING
PROTEIN FAMILY B
MEMBER 1

(Mus musculus) 		PF00169
(PH) 		3 ASN A  27
VAL A  70
HIS A  93
 None
 0.87A 6a5yD-2d9vA:
undetectable		 6a5yD-2d9vA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dhx POLY (ADP-RIBOSE)
POLYMERASE FAMILY,
MEMBER 10 VARIANT

(Homo sapiens) 		no annotation 3 ASN A  31
VAL A  20
HIS A  72
 None
 0.74A 6a5yD-2dhxA:
undetectable		 6a5yD-2dhxA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ec5 DERMONECROTIC TOXIN

(Pasteurella
multocida) 		PF11647
(MLD) 		3 ASN A 625
VAL A 590
HIS A 622
 None
 0.75A 6a5yD-2ec5A:
undetectable		 6a5yD-2ec5A:
6.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6d GLUCOAMYLASE GLU1

(Saccharomycopsis
fibuligera) 		PF00723
(Glyco_hydro_15) 		3 ASN A 455
VAL A 443
HIS A 447
 None
None
ACR  A 996 (-3.4A)
 0.87A 6a5yD-2f6dA:
undetectable		 6a5yD-2f6dA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk7 SHIKIMATE
DEHYDROGENASE

(Aquifex
aeolicus) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		3 ASN A 201
VAL A 181
HIS A 209
 None
 0.79A 6a5yD-2hk7A:
undetectable		 6a5yD-2hk7A:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i58 SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF13416
(SBP_bac_8) 		3 ASN A 296
VAL A   6
HIS A 291
 None
 0.81A 6a5yD-2i58A:
undetectable		 6a5yD-2i58A:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ibu ACETYL-COA
ACETYLTRANSFERASE

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		3 ASN A 189
VAL A 180
HIS A 192
 None
None
COA  A6001 (-4.5A)
 0.86A 6a5yD-2ibuA:
undetectable		 6a5yD-2ibuA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3t TRAFFICKING PROTEIN
PARTICLE COMPLEX
SUBUNIT 1

(Mus musculus) 		PF04099
(Sybindin) 		3 ASN C   5
VAL C  90
HIS C  72
 None
 0.88A 6a5yD-2j3tC:
undetectable		 6a5yD-2j3tC:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jhq URACIL
DNA-GLYCOSYLASE

(Vibrio cholerae) 		PF03167
(UDG) 		3 ASN A 123
VAL A  27
HIS A 136
 None
 0.86A 6a5yD-2jhqA:
undetectable		 6a5yD-2jhqA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kii PUTATIVE
UNCHARACTERIZED
PROTEIN

(Shewanella
oneidensis) 		PF07700
(HNOB) 		3 ASN A   7
VAL A 106
HIS A  81
 None
HEM  A 182 (-4.0A)
HEM  A 182 (-2.9A)
 0.75A 6a5yD-2kiiA:
undetectable		 6a5yD-2kiiA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN

(Porphyromonas
gingivalis) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		3 ASN A  51
VAL A  15
HIS A  16
 ASN  A  51 ( 0.6A)
VAL  A  15 ( 0.6A)
HIS  A  16 ( 1.0A)
 0.83A 6a5yD-2nvvA:
undetectable		 6a5yD-2nvvA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE

(Cryptosporidium
parvum) 		PF00348
(polyprenyl_synt) 		3 ASN A  30
VAL A  68
HIS A  73
 None
 0.83A 6a5yD-2o1oA:
undetectable		 6a5yD-2o1oA:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6l UDP-GLUCURONOSYLTRAN
SFERASE 2B7

(Homo sapiens) 		PF00201
(UDPGT) 		3 ASN A 360
VAL A 296
HIS A 365
 None
 0.85A 6a5yD-2o6lA:
undetectable		 6a5yD-2o6lA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pk0 SERINE/THREONINE
PROTEIN PHOSPHATASE
STP1

(Streptococcus
agalactiae) 		PF13672
(PP2C_2) 		3 ASN A 160
VAL A 116
HIS A 136
 None
 0.84A 6a5yD-2pk0A:
undetectable		 6a5yD-2pk0A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppv UNCHARACTERIZED
PROTEIN

(Staphylococcus
epidermidis) 		PF01933
(UPF0052) 		3 ASN A 290
VAL A 217
HIS A 302
 None
 0.64A 6a5yD-2ppvA:
undetectable		 6a5yD-2ppvA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyu INOSINE TRIPHOSPHATE
PYROPHOSPHATASE RDGB

(Escherichia
coli) 		PF01725
(Ham1p_like) 		3 ASN A  49
VAL A  36
HIS A  56
 None
 0.79A 6a5yD-2pyuA:
undetectable		 6a5yD-2pyuA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1f CHONDROITINASE

(Bacteroides
thetaiotaomicron) 		PF02278
(Lyase_8)
PF09092
(Lyase_N)
PF09093
(Lyase_catalyt) 		3 ASN A 573
VAL A 463
HIS A 526
 None
 0.78A 6a5yD-2q1fA:
undetectable		 6a5yD-2q1fA:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q7x UPF0052 PROTEIN
SP_1565

(Streptococcus
pneumoniae) 		PF01933
(UPF0052) 		3 ASN A  60
VAL A 221
HIS A 308
 None
 0.70A 6a5yD-2q7xA:
undetectable		 6a5yD-2q7xA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rm6 GLUTATHIONE
PEROXIDASE-LIKE
PROTEIN

(Trypanosoma
brucei) 		PF00255
(GSHPx) 		3 ASN A  77
VAL A  20
HIS A 116
 None
 0.88A 6a5yD-2rm6A:
undetectable		 6a5yD-2rm6A:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uzx HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF01403
(Sema)
PF01437
(PSI)
PF01833
(TIG) 		3 ASN B 594
VAL B 465
HIS B 476
 None
 0.86A 6a5yD-2uzxB:
undetectable		 6a5yD-2uzxB:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v0j BIFUNCTIONAL PROTEIN
GLMU

(Haemophilus
influenzae) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		3 ASN A 305
VAL A 252
HIS A 268
 None
 0.84A 6a5yD-2v0jA:
undetectable		 6a5yD-2v0jA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vmf BETA-MANNOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2) 		3 ASN A  71
VAL A  84
HIS A  60
 None
 0.69A 6a5yD-2vmfA:
undetectable		 6a5yD-2vmfA:
7.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5e PROTEASOME
ASSEMBLING CHAPERONE
3

(Homo sapiens) 		PF10178
(PAC3) 		3 ASN A  81
VAL A  66
HIS A  76
 None
 0.70A 6a5yD-2z5eA:
undetectable		 6a5yD-2z5eA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbz CYTOCHROME P450-SU1

(Streptomyces
griseolus) 		PF00067
(p450) 		3 ASN A  72
VAL A 352
HIS A 103
 None
None
HEM  A 413 (-3.9A)
 0.57A 6a5yD-2zbzA:
undetectable		 6a5yD-2zbzA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3h ENDOGLUCANASE

(Salipaludibacillus
agaradhaerens) 		PF00150
(Cellulase) 		3 ASN A 131
VAL A  27
HIS A   9
 None
 0.78A 6a5yD-3a3hA:
undetectable		 6a5yD-3a3hA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e77 PHOSPHOSERINE
AMINOTRANSFERASE

(Homo sapiens) 		PF00266
(Aminotran_5) 		3 ASN A 297
VAL A 338
HIS A 158
 None
 0.86A 6a5yD-3e77A:
undetectable		 6a5yD-3e77A:
11.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3eyb NUCLEAR HORMONE
RECEPTOR RXR

(Branchiostoma
floridae) 		PF00104
(Hormone_recep) 		3 ASN A 335
VAL A 371
HIS A 464
 None
 0.60A 6a5yD-3eybA:
29.0		 6a5yD-3eybA:
75.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxg RHAMNONATE
DEHYDRATASE

(Fusarium
graminearum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ASN A 290
VAL A 235
HIS A 265
 None
 0.72A 6a5yD-3fxgA:
undetectable		 6a5yD-3fxgA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7s LONG-CHAIN-FATTY-ACI
D--COA LIGASE
(FADD-1)

(Archaeoglobus
fulgidus) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 ASN A 135
VAL A 151
HIS A 129
 None
 0.87A 6a5yD-3g7sA:
undetectable		 6a5yD-3g7sA:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcg L0028 (MITOCHONDRIA
ASSOCIATED PROTEIN)

(Escherichia
coli) 		PF03278
(IpaB_EvcA) 		3 ASN B  56
VAL B 169
HIS B  51
 None
 0.68A 6a5yD-3gcgB:
undetectable		 6a5yD-3gcgB:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5t AMINOTRANSFERASE

(Rhodobacter
sphaeroides) 		PF00202
(Aminotran_3) 		3 ASN A 169
VAL A 148
HIS A 154
 None
 0.68A 6a5yD-3i5tA:
undetectable		 6a5yD-3i5tA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k55 BETA-HEMOLYSIN

(Staphylococcus
aureus) 		PF03372
(Exo_endo_phos) 		3 ASN A 214
VAL A 178
HIS A 254
 None
 0.87A 6a5yD-3k55A:
undetectable		 6a5yD-3k55A:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kcu PROBABLE FORMATE
TRANSPORTER 1

(Escherichia
coli) 		PF01226
(Form_Nir_trans) 		3 ASN A 241
VAL A 157
HIS A 244
 None
 0.85A 6a5yD-3kcuA:
undetectable		 6a5yD-3kcuA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl0 GLUCURONOXYLANASE
XYNC

(Bacillus
subtilis) 		PF17189
(Glyco_hydro_30C) 		3 ASN A 162
VAL A  56
HIS A 117
 None
 0.81A 6a5yD-3kl0A:
undetectable		 6a5yD-3kl0A:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwe ATP-CITRATE SYNTHASE

(Homo sapiens) 		PF16114
(Citrate_bind) 		3 ASN A 203
VAL A 111
HIS A 113
 None
 0.84A 6a5yD-3mweA:
undetectable		 6a5yD-3mweA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0q PUTATIVE
AROMATIC-RING
HYDROXYLATING
DIOXYGENASE

(Ruegeria sp.
TM1040) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		3 ASN A  11
VAL A  28
HIS A   2
 None
 0.81A 6a5yD-3n0qA:
undetectable		 6a5yD-3n0qA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6r PROPIONYL-COA
CARBOXYLASE, ALPHA
SUBUNIT

(Ruegeria
pomeroyi) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		3 ASN A 398
VAL A 475
HIS A 480
 None
 0.79A 6a5yD-3n6rA:
undetectable		 6a5yD-3n6rA:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odp PUTATIVE
TAGATOSE-6-PHOSPHATE
KETOSE/ALDOSE
ISOMERASE

(Clostridium
novyi) 		PF01380
(SIS) 		3 ASN A 145
VAL A 127
HIS A 153
 None
 0.82A 6a5yD-3odpA:
undetectable		 6a5yD-3odpA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pig BETA-FRUCTOFURANOSID
ASE

(Bifidobacterium
longum) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		3 ASN A 272
VAL A 431
HIS A 299
 None
 0.80A 6a5yD-3pigA:
undetectable		 6a5yD-3pigA:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pmc UNCHARACTERIZED
PROTEIN
PXO2-61/BXB0075/GBAA
_PXO2_0075

(Bacillus
anthracis) 		PF09385
(HisK_N) 		3 ASN A  80
VAL A  27
HIS A  86
 None
 0.85A 6a5yD-3pmcA:
undetectable		 6a5yD-3pmcA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q8n 4-AMINOBUTYRATE
TRANSAMINASE

(Mycolicibacterium
smegmatis) 		PF00202
(Aminotran_3) 		3 ASN A  64
VAL A 411
HIS A 405
 None
 0.81A 6a5yD-3q8nA:
undetectable		 6a5yD-3q8nA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rde ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE

(Sus scrofa) 		PF00305
(Lipoxygenase) 		3 ASN A 152
VAL A 661
HIS A 366
 None
None
FE2  A   1 ( 3.4A)
 0.79A 6a5yD-3rdeA:
undetectable		 6a5yD-3rdeA:
8.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr7 URACIL-DNA
GLYCOSYLASE

(Coxiella
burnetii) 		PF03167
(UDG) 		3 ASN A 125
VAL A  30
HIS A 138
 None
 0.87A 6a5yD-3tr7A:
undetectable		 6a5yD-3tr7A:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ty9 POLYNUCLEOTIDE
2',3'-CYCLIC
PHOSPHATE
PHOSPHODIESTERASE /
POLYNUCLEOTIDE
5'-HYDROXYL-KINASE /
POLYNUCLEOTIDE
3'-PHOSPHATASE

(Ruminiclostridium
thermocellum) 		PF16536
(PNKP-ligase_C)
PF16542
(PNKP_ligase) 		3 ASN A 718
VAL A 713
HIS A 714
 None
 0.85A 6a5yD-3ty9A:
undetectable		 6a5yD-3ty9A:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxf UNCHARACTERIZED
PROTEIN

(Danio rerio) 		PF00443
(UCH) 		3 ASN A 860
VAL A 722
HIS A 854
 None
 0.88A 6a5yD-3wxfA:
undetectable		 6a5yD-3wxfA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aig ADAMALYSIN II

(Crotalus
adamanteus) 		PF01421
(Reprolysin) 		3 ASN A 102
VAL A 136
HIS A 129
 None
 0.87A 6a5yD-4aigA:
undetectable		 6a5yD-4aigA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4apl APICAL MEMBRANE
ANTIGEN 1

(Neospora
caninum) 		PF02430
(AMA-1) 		3 ASN A 282
VAL A  89
HIS A  85
 None
 0.85A 6a5yD-4aplA:
undetectable		 6a5yD-4aplA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci0 F420-REDUCING
HYDROGENASE, SUBUNIT
ALPHA

(Methanothermobacter
marburgensis) 		PF00374
(NiFeSe_Hases) 		3 ASN A 104
VAL A 186
HIS A 185
 None
 0.79A 6a5yD-4ci0A:
undetectable		 6a5yD-4ci0A:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fnv HEPARINASE III
PROTEIN, HEPARITIN
SULFATE LYASE

(Bacteroides
thetaiotaomicron) 		PF07940
(Hepar_II_III)
PF16889
(Hepar_II_III_N) 		3 ASN A 374
VAL A 353
HIS A 315
 None
 0.80A 6a5yD-4fnvA:
undetectable		 6a5yD-4fnvA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lyl URACIL-DNA
GLYCOSYLASE

(Gadus morhua) 		PF03167
(UDG) 		3 ASN A 204
VAL A 109
HIS A 217
 None
 0.83A 6a5yD-4lylA:
undetectable		 6a5yD-4lylA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nb0 METALLOTHIOL
TRANSFERASE FOSB

(Staphylococcus
aureus) 		PF00903
(Glyoxalase) 		3 ASN A  89
VAL A  12
HIS A 112
 None
 0.67A 6a5yD-4nb0A:
undetectable		 6a5yD-4nb0A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzj PUTATIVE
ALPHA-GALACTOSIDASE

(Bacteroides
fragilis) 		PF05345
(He_PIG)
PF10632
(He_PIG_assoc)
PF16499
(Melibiase_2) 		3 ASN A 339
VAL A 273
HIS A 294
 None
 0.86A 6a5yD-4nzjA:
undetectable		 6a5yD-4nzjA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ogz PUTATIVE
ALPHA-GALACTOSIDASE/
MELIBIASE

(Bacteroides
fragilis) 		PF10632
(He_PIG_assoc)
PF16499
(Melibiase_2)
PF17450
(Melibiase_2_C) 		3 ASN A 339
VAL A 273
HIS A 294
 None
 0.86A 6a5yD-4ogzA:
undetectable		 6a5yD-4ogzA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxg TYPE-2 RESTRICTION
ENZYME SAU3AI

(Staphylococcus
aureus) 		PF02976
(MutH) 		3 ASN A 478
VAL A 358
HIS A 307
 None
 0.83A 6a5yD-4pxgA:
undetectable		 6a5yD-4pxgA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qr8 XAA-PRO DIPEPTIDASE

(Escherichia
coli) 		PF00557
(Peptidase_M24) 		3 ASN A 179
VAL A 212
HIS A 207
 None
 0.85A 6a5yD-4qr8A:
undetectable		 6a5yD-4qr8A:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1z CYP17A1 PROTEIN

(Danio rerio) 		PF00067
(p450) 		3 ASN A 406
VAL A 392
HIS A  94
 None
 0.77A 6a5yD-4r1zA:
undetectable		 6a5yD-4r1zA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upk PHOSPHONATE
MONOESTER HYDROLASE

(Ruegeria
pomeroyi) 		PF00884
(Sulfatase) 		3 ASN A 487
VAL A  72
HIS A  69
 None
 0.81A 6a5yD-4upkA:
undetectable		 6a5yD-4upkA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		3 ASN A 863
VAL A 778
HIS A 827
 None
 0.54A 6a5yD-4w8jA:
undetectable		 6a5yD-4w8jA:
5.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wh0 PUTATIVE HYDROLASE

(Pseudomonas
aeruginosa) 		PF00857
(Isochorismatase) 		3 ASN A  38
VAL A 113
HIS A  20
 None
 0.82A 6a5yD-4wh0A:
undetectable		 6a5yD-4wh0A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yry DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A

(Thermotoga
maritima) 		PF07992
(Pyr_redox_2)
PF14691
(Fer4_20) 		3 ASN B 289
VAL B  23
HIS B 326
 FAD  B 503 (-3.8A)
None
None
 0.80A 6a5yD-4yryB:
undetectable		 6a5yD-4yryB:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yu5 IMMUNE INHIBITOR A,
METALLOPROTEASE

(Bacillus cereus) 		PF05547
(Peptidase_M6) 		3 ASN A 764
VAL A 753
HIS A 701
 None
 0.87A 6a5yD-4yu5A:
undetectable		 6a5yD-4yu5A:
7.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5afd N-ACETYLNEURAMINATE
LYASE

(Aliivibrio
salmonicida) 		PF00701
(DHDPS) 		3 ASN A  22
VAL A 254
HIS A  12
 None
 0.53A 6a5yD-5afdA:
undetectable		 6a5yD-5afdA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cfa BONE
SIALOPROTEIN-BINDING
PROTEIN

(Staphylococcus
aureus) 		PF10425
(SdrG_C_C) 		3 ASN A 143
VAL A 123
HIS A  59
 None
 0.79A 6a5yD-5cfaA:
undetectable		 6a5yD-5cfaA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chv UBL
CARBOXYL-TERMINAL
HYDROLASE 18

(Mus musculus) 		PF00443
(UCH) 		3 ASN A  56
VAL A 129
HIS A 135
 None
SO4  A 402 ( 4.0A)
SO4  A 402 (-3.5A)
 0.75A 6a5yD-5chvA:
undetectable		 6a5yD-5chvA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9u GLYCOSYLTRANSFERASE-
STABILIZING PROTEIN
GTF2

(Streptococcus
gordonii) 		no annotation 3 ASN B 338
VAL B 363
HIS B 293
 None
 0.86A 6a5yD-5e9uB:
undetectable		 6a5yD-5e9uB:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f6q METALLOTHIOL
TRANSFERASE FOSB 2

(Bacillus
anthracis) 		PF00903
(Glyoxalase) 		3 ASN A  89
VAL A  12
HIS A 112
 None
 0.81A 6a5yD-5f6qA:
undetectable		 6a5yD-5f6qA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jfc NADH-DEPENDENT
FERREDOXIN:NADP
OXIDOREDUCTASE
SUBUNIT ALPHA

(Pyrococcus
furiosus) 		PF07992
(Pyr_redox_2)
PF14691
(Fer4_20) 		3 ASN L 303
VAL L  26
HIS L 339
 FAD  L 503 (-3.7A)
None
None
 0.78A 6a5yD-5jfcL:
undetectable		 6a5yD-5jfcL:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1s OXIDOREDUCTASE,
ZINC-BINDING
DEHYDROGENASE FAMILY

(Myxococcus
xanthus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 ASN A 331
VAL A  39
HIS A 326
 None
 0.85A 6a5yD-5k1sA:
undetectable		 6a5yD-5k1sA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5koj NITROGENASE PROTEIN
ALPHA CHAIN

(Gluconacetobacter
diazotrophicus) 		PF00148
(Oxidored_nitro) 		3 ASN A 114
VAL A 371
HIS A 458
 None
ICS  A 502 ( 4.4A)
ICS  A 502 ( 3.6A)
 0.75A 6a5yD-5kojA:
undetectable		 6a5yD-5kojA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lwg VP3

(Israeli acute
paralysis virus) 		no annotation 3 ASN C 197
VAL C 256
HIS C 149
 None
 0.76A 6a5yD-5lwgC:
undetectable		 6a5yD-5lwgC:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlg RENIN

(Rattus
norvegicus) 		no annotation 3 ASN A  86
VAL A 147
HIS A 189
 None
 0.86A 6a5yD-5mlgA:
undetectable		 6a5yD-5mlgA:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqo NON-REDUCING END
BETA-L-ARABINOFURANO
SIDASE

(Bacteroides
thetaiotaomicron) 		PF07944
(Glyco_hydro_127) 		3 ASN A  48
VAL A 116
HIS A  45
 None
 0.81A 6a5yD-5mqoA:
undetectable		 6a5yD-5mqoA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msw THIOESTER REDUCTASE
DOMAIN-CONTAINING
PROTEIN

(Segniliparus
rugosus) 		PF00501
(AMP-binding)
PF00550
(PP-binding) 		3 ASN A 731
VAL A 720
HIS A 738
 None
 0.86A 6a5yD-5mswA:
undetectable		 6a5yD-5mswA:
5.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ndx GLYCOSYL HYDROLASE

(Rhizobium
leguminosarum) 		no annotation 3 ASN A 306
VAL A 239
HIS A 295
 None
 0.81A 6a5yD-5ndxA:
undetectable		 6a5yD-5ndxA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t2k PUTATIVE
HEME-DEPENDENT
PEROXIDASE
GT50_08830

(Geobacillus
stearothermophilus) 		PF06778
(Chlor_dismutase) 		3 ASN A 241
VAL A 248
HIS A 247
 None
 0.80A 6a5yD-5t2kA:
undetectable		 6a5yD-5t2kA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t8u LIPOATE-PROTEIN
LIGASE 1

(Plasmodium
falciparum) 		PF03099
(BPL_LplA_LipB)
PF10437
(Lip_prot_lig_C) 		3 ASN A  80
VAL A 354
HIS A 329
 None
 0.74A 6a5yD-5t8uA:
undetectable		 6a5yD-5t8uA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tzb D-AMINOPEPTIDASE

(Burkholderia
sp. LK4) 		PF03576
(Peptidase_S58) 		3 ASN A 201
VAL A 269
HIS A 172
 None
 0.80A 6a5yD-5tzbA:
undetectable		 6a5yD-5tzbA:
12.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uan RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		no annotation 3 ASN A 306
VAL A 342
HIS A 435
 None
 0.30A 6a5yD-5uanA:
34.7		 6a5yD-5uanA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vj7 OXIDOREDUCTASE

(Pyrococcus
furiosus) 		PF07992
(Pyr_redox_2)
PF14691
(Fer4_20) 		3 ASN A 303
VAL A  26
HIS A 339
 FAD  A 503 (-3.2A)
None
None
 0.75A 6a5yD-5vj7A:
undetectable		 6a5yD-5vj7A:
11.44