SIMILAR PATTERNS OF AMINO ACIDS FOR 6A4I_D_TRPD403

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hka TRYPTOPHAN
2,3-DIOXYGENASE

(Drosophila
melanogaster) 		PF03301
(Trp_dioxygenase) 		5 TRP A 192
ARG A 195
THR A 196
PRO A 197
PRO A 291
 None
 0.75A 6a4iD-4hkaA:
31.8		 6a4iD-4hkaA:
52.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hka TRYPTOPHAN
2,3-DIOXYGENASE

(Drosophila
melanogaster) 		PF03301
(Trp_dioxygenase) 		5 TRP A 192
THR A 196
PRO A 197
ILE A 279
PRO A 291
 None
 0.64A 6a4iD-4hkaA:
31.8		 6a4iD-4hkaA:
52.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4pw8 TRYPTOPHAN
2,3-DIOXYGENASE

(Homo sapiens) 		PF03301
(Trp_dioxygenase) 		6 TRP A 208
THR A 212
PRO A 213
ILE A 295
ARG A 303
PRO A 307
 None
 1.13A 6a4iD-4pw8A:
30.6		 6a4iD-4pw8A:
99.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cww NUCLEOPORIN NUP82

(Chaetomium
thermophilum) 		no annotation 5 ARG B 291
TRP B 292
PRO B 342
ILE B 299
PRO B 294
 None
 1.40A 6a4iD-5cwwB:
undetectable		 6a4iD-5cwwB:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en4 SPLICING FACTOR 3B
SUBUNIT 3

(Homo sapiens) 		no annotation 5 GLU A 576
THR A 538
PRO A 539
ILE A 544
ARG A 580
 None
 0.77A 6a4iD-6en4A:
0.1		 6a4iD-6en4A:
undetectable