SIMILAR PATTERNS OF AMINO ACIDS FOR 6A4I_B_TRPB403

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dju AROMATIC
AMINOTRANSFERASE

(Pyrococcus
horikoshii) 		PF00155
(Aminotran_1_2) 		4 ARG A 326
ARG A 324
THR A 312
PRO A 323
 None
 1.28A 6a4iB-1djuA:
undetectable		 6a4iB-1djuA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fep FERRIC ENTEROBACTIN
RECEPTOR

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 ARG A 714
THR A 715
PRO A 164
PRO A 712
 None
 1.48A 6a4iB-1fepA:
undetectable		 6a4iB-1fepA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1frr FERREDOXIN I

(Equisetum
arvense) 		PF00111
(Fer2) 		4 GLU A  92
THR A   8
PRO A   9
PRO A  35
 None
 1.10A 6a4iB-1frrA:
undetectable		 6a4iB-1frrA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gl6 ATPASE

(Escherichia
coli) 		PF10412
(TrwB_AAD_bind) 		4 ARG A 350
GLU A 346
PRO A 308
PRO A 344
 None
 1.44A 6a4iB-1gl6A:
undetectable		 6a4iB-1gl6A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1idu VANADIUM
CHLOROPEROXIDASE

(Curvularia
inaequalis) 		PF01569
(PAP2) 		4 GLU A 443
ARG A 302
THR A 299
PRO A 300
 None
 1.45A 6a4iB-1iduA:
undetectable		 6a4iB-1iduA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ii0 ARSENICAL
PUMP-DRIVING ATPASE

(Escherichia
coli) 		PF02374
(ArsA_ATPase) 		4 ARG A 434
THR A 480
PRO A 481
PRO A 450
 None
 1.04A 6a4iB-1ii0A:
0.0		 6a4iB-1ii0A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mro METHYL-COENZYME M
REDUCTASE

(Methanothermobacter
marburgensis) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		4 ARG A 471
GLU A 469
THR A 422
PRO A 495
 None
 1.04A 6a4iB-1mroA:
0.0		 6a4iB-1mroA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfd N15 ALPHA-BETA
T-CELL RECEPTOR
H57 FAB

(Mus musculus;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		4 TRP F  33
ARG F  71
PRO F  52
PRO B 230
 None
 1.31A 6a4iB-1nfdF:
undetectable		 6a4iB-1nfdF:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 ARG A 479
GLU A 478
TRP A 449
PRO A 460
 None
 1.46A 6a4iB-1opkA:
0.1		 6a4iB-1opkA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Escherichia
coli) 		PF00311
(PEPcase) 		4 ARG A 195
GLU A 201
THR A 140
PRO A 139
 None
 1.31A 6a4iB-1qb4A:
0.0		 6a4iB-1qb4A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r76 PECTATE LYASE

(Niveispirillum
irakense) 		PF09492
(Pec_lyase) 		4 ARG A 162
THR A 119
PRO A 120
PRO A 223
 None
 1.01A 6a4iB-1r76A:
0.1		 6a4iB-1r76A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w36 EXODEOXYRIBONUCLEASE
V GAMMA CHAIN

(Escherichia
coli) 		PF04257
(Exonuc_V_gamma) 		4 GLU C  83
TRP C  70
ARG C 186
PRO C  81
 None
 1.50A 6a4iB-1w36C:
undetectable		 6a4iB-1w36C:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ztv HYPOTHETICAL PROTEIN

(Enterococcus
faecalis) 		PF01904
(DUF72) 		4 ARG A 212
TRP A 201
THR A 174
PRO A 176
 CL  A 278 ( 4.6A)
None
None
None
 1.34A 6a4iB-1ztvA:
undetectable		 6a4iB-1ztvA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Thermus
thermophilus) 		PF01409
(tRNA-synt_2d)
PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		4 ARG B 450
ARG B 164
THR B 161
PRO B 162
 None
 1.50A 6a4iB-2amcB:
undetectable		 6a4iB-2amcB:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1u DI-HAEM CYTOCHROME C
PEROXIDASE

(Paracoccus
pantotrophus) 		PF00034
(Cytochrom_C)
PF03150
(CCP_MauG) 		4 ARG A 186
GLU A  23
THR A 179
PRO A  22
 None
 1.41A 6a4iB-2c1uA:
undetectable		 6a4iB-2c1uA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e67 HYPOTHETICAL PROTEIN
TTHB029

(Thermus
thermophilus) 		PF04794
(YdjC) 		4 ARG A 148
GLU A 145
PRO A 151
PRO A 178
 None
 1.45A 6a4iB-2e67A:
undetectable		 6a4iB-2e67A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fea 2-HYDROXY-3-KETO-5-M
ETHYLTHIOPENTENYL-1-
PHOSPHATE
PHOSPHATASE

(Bacillus
subtilis) 		PF12710
(HAD) 		4 ARG A  78
GLU A 209
ARG A 187
PRO A 203
 None
 1.46A 6a4iB-2feaA:
undetectable		 6a4iB-2feaA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmi UBIQUITIN-CONJUGATIN
G ENZYME VARIANT
MMS2

(Saccharomyces
cerevisiae) 		PF00179
(UQ_con) 		4 ARG B 117
THR B 122
PRO B 123
PRO B  84
 None
 1.04A 6a4iB-2gmiB:
undetectable		 6a4iB-2gmiB:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gou OXIDOREDUCTASE,
FMN-BINDING

(Shewanella
oneidensis) 		PF00724
(Oxidored_FMN) 		4 GLU A 271
ARG A 233
PRO A 236
PRO A 278
 None
FMN  A4401 (-2.8A)
None
None
 1.30A 6a4iB-2gouA:
undetectable		 6a4iB-2gouA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gy5 ANGIOPOIETIN-1
RECEPTOR

(Homo sapiens) 		PF10430
(Ig_Tie2_1) 		4 GLU A 382
ARG A 347
THR A 349
PRO A 350
 None
None
SO4  A   5 (-3.5A)
None
 1.32A 6a4iB-2gy5A:
undetectable		 6a4iB-2gy5A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i4n PROLINE-TRNA LIGASE

(Rhodopseudomonas
palustris) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		4 GLU A  92
ARG A  95
PRO A 108
PRO A 201
 None
 1.33A 6a4iB-2i4nA:
undetectable		 6a4iB-2i4nA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivf ETHYLBENZENE
DEHYDROGENASE
ALPHA-SUBUNIT

(Aromatoleum
aromaticum) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		4 ARG A 149
ARG A 153
PRO A 622
PRO A 610
 None
 1.36A 6a4iB-2ivfA:
undetectable		 6a4iB-2ivfA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqp LARGE CAPSID PROTEIN

(Providence
virus) 		PF03566
(Peptidase_A21) 		4 ARG A 144
GLU A 166
THR A 169
PRO A 199
 None
 1.33A 6a4iB-2qqpA:
undetectable		 6a4iB-2qqpA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rko VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 4

(Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF09336
(Vps4_C) 		4 GLU A 398
THR A 315
PRO A 316
PRO A 350
 None
 0.96A 6a4iB-2rkoA:
undetectable		 6a4iB-2rkoA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vmf BETA-MANNOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2) 		4 ARG A 382
GLU A 375
ARG A 823
PRO A 844
 None
 1.34A 6a4iB-2vmfA:
2.1		 6a4iB-2vmfA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhe UNC18
SYNTAXIN1

(Monosiga
brevicollis;
Monosiga
brevicollis) 		PF00995
(Sec1)
PF00804
(Syntaxin)
PF05739
(SNARE) 		4 ARG A  90
THR A  91
PRO A  92
PRO B  39
 None
 1.15A 6a4iB-2xheA:
undetectable		 6a4iB-2xheA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsw 72 KDA INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		4 GLU A 320
THR A 581
PRO A 315
PRO A 586
 None
 1.45A 6a4iB-2xswA:
undetectable		 6a4iB-2xswA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yg6 PUTRESCINE OXIDASE

(Rhodococcus
erythropolis) 		PF01593
(Amino_oxidase) 		4 ARG A 442
ARG A 412
THR A 413
PRO A 414
 None
None
None
GOL  A1452 (-3.7A)
 1.34A 6a4iB-2yg6A:
undetectable		 6a4iB-2yg6A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ab0 ANTIBODY SCFV
FRAGMENT, HEAVY
CHAIN

(Mus musculus) 		PF07686
(V-set) 		4 GLU B  88
ARG B  38
THR B  40
PRO B  41
 None
 1.31A 6a4iB-3ab0B:
undetectable		 6a4iB-3ab0B:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3be3 UNCHARACTERIZED
PROTEIN

(Bordetella
bronchiseptica) 		PF07866
(DUF1653) 		4 ARG A  53
ARG A  71
THR A  61
PRO A  70
 SO4  A 200 (-2.8A)
SO4  A 200 (-4.0A)
None
None
 1.39A 6a4iB-3be3A:
undetectable		 6a4iB-3be3A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkq PKHD-TYPE
HYDROXYLASE
SBAL_3634

(Shewanella
baltica) 		PF13640
(2OG-FeII_Oxy_3) 		4 ARG A 179
ARG A 110
THR A 111
PRO A 152
 GOL  A 503 (-3.7A)
None
None
None
 1.49A 6a4iB-3dkqA:
undetectable		 6a4iB-3dkqA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dl3 TELLURITE RESISTANCE
PROTEIN B

(Aliivibrio
fischeri) 		PF09313
(DUF1971) 		4 ARG A  14
THR A  16
PRO A  17
PRO A  25
 None
 1.03A 6a4iB-3dl3A:
undetectable		 6a4iB-3dl3A:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e6e ALANINE RACEMASE

(Enterococcus
faecalis) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 ARG A 248
GLU A 369
THR A   9
PRO A 367
 None
 1.34A 6a4iB-3e6eA:
undetectable		 6a4iB-3e6eA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3euj CHROMOSOME PARTITION
PROTEIN MUKB, LINKER

([Haemophilus]
ducreyi) 		PF04310
(MukB)
PF13558
(SbcCD_C) 		4 ARG A 218
GLU A1416
ARG A 216
PRO A 214
 None
 1.31A 6a4iB-3eujA:
undetectable		 6a4iB-3eujA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7j GLUTATHIONE
TRANSFERASE GST1-4

(Anopheles dirus) 		PF02798
(GST_N)
PF13410
(GST_C_2) 		4 GLU A  65
TRP A  64
THR A  54
PRO A  53
 GTX  A 220 (-3.2A)
None
None
GTX  A 220 (-4.3A)
 1.41A 6a4iB-3g7jA:
3.6		 6a4iB-3g7jA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gg4 GLYCEROL KINASE

(Yersinia
pseudotuberculosis) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 ARG A  25
GLU A 473
ARG A 504
PRO A 471
 None
 1.09A 6a4iB-3gg4A:
undetectable		 6a4iB-3gg4A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpa AMIDOHYDROLASE

(unidentified) 		PF01979
(Amidohydro_1) 		4 ARG A 396
ARG A 176
THR A 148
PRO A  87
 None
 1.44A 6a4iB-3hpaA:
undetectable		 6a4iB-3hpaA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kxd CALCIUM-GATED
POTASSIUM CHANNEL
MTHK

(Methanothermobacter
thermautotrophicus) 		PF02080
(TrkA_C)
PF02254
(TrkA_N) 		4 GLU A 144
ARG A 166
THR A 165
PRO A 164
 CD  A 603 (-3.7A)
None
None
None
 1.46A 6a4iB-3kxdA:
undetectable		 6a4iB-3kxdA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lyp STRINGENT STARVATION
PROTEIN A

(Pseudomonas
protegens) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		4 GLU A  69
TRP A  68
THR A  59
PRO A  58
 None
 1.34A 6a4iB-3lypA:
2.2		 6a4iB-3lypA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n40 P62 ENVELOPE
GLYCOPROTEIN

(Chikungunya
virus) 		PF00943
(Alpha_E2_glycop)
PF01563
(Alpha_E3_glycop) 		4 ARG P 262
THR P 239
PRO P 240
PRO P 307
 None
 1.26A 6a4iB-3n40P:
undetectable		 6a4iB-3n40P:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nie MAP2 KINASE

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		4 ARG A 223
TRP A 221
PRO A 159
PRO A 266
 None
 1.43A 6a4iB-3nieA:
undetectable		 6a4iB-3nieA:
25.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I

(Yersinia pestis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 GLU A 310
ARG A 227
THR A 301
PRO A 273
 None
 1.42A 6a4iB-3oytA:
undetectable		 6a4iB-3oytA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3paj NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE,
CARBOXYLATING

(Vibrio cholerae) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		4 ARG A  24
GLU A  75
TRP A  72
PRO A  19
 None
 1.48A 6a4iB-3pajA:
undetectable		 6a4iB-3pajA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qlv GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 5

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		4 ARG A 154
GLU A 156
THR A 106
PRO A 107
 None
 1.38A 6a4iB-3qlvA:
undetectable		 6a4iB-3qlvA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rcy MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN

(Roseovarius sp.
TM1035) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ARG A 159
THR A 339
PRO A 340
PRO A  16
 None
 1.15A 6a4iB-3rcyA:
undetectable		 6a4iB-3rcyA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s1s RESTRICTION
ENDONUCLEASE BPUSI

(Bacillus
pumilus) 		PF02384
(N6_Mtase)
PF15516
(BpuSI_N) 		5 ARG A 271
GLU A 204
ARG A 211
THR A 219
PRO A 218
 None
EDO  A 910 (-3.4A)
None
None
IOD  A 933 (-4.0A)
 1.45A 6a4iB-3s1sA:
undetectable		 6a4iB-3s1sA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t4w MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Sulfitobacter
sp. NAS-14.1) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ARG A 159
THR A 339
PRO A 340
PRO A  16
 None
 1.16A 6a4iB-3t4wA:
undetectable		 6a4iB-3t4wA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr5 PEPTIDE CHAIN
RELEASE FACTOR 3

(Coxiella
burnetii) 		PF00009
(GTP_EFTU)
PF16658
(RF3_C) 		4 ARG A 130
GLU A 524
ARG A 278
THR A 280
 None
 1.37A 6a4iB-3tr5A:
undetectable		 6a4iB-3tr5A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vu2 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME,
CHLOROPLASTIC/AMYLOP
LASTIC

(Oryza sativa) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		4 GLU A 166
ARG A 201
THR A 249
PRO A 162
 None
 1.43A 6a4iB-3vu2A:
undetectable		 6a4iB-3vu2A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x27 CUCUMOPINE SYNTHASE

(Marinactinospora
thermotolerans) 		no annotation 4 ARG A 151
THR A 152
PRO A 153
PRO A  59
 None
 1.39A 6a4iB-3x27A:
2.4		 6a4iB-3x27A:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x3y PHENYLETHYLAMINE
OXIDASE

(Arthrobacter
globiformis) 		PF01179
(Cu_amine_oxid)
PF02728
(Cu_amine_oxidN3) 		4 ARG A 551
GLU A 253
THR A 554
PRO A 553
 None
None
GOL  A 703 (-4.6A)
None
 1.42A 6a4iB-3x3yA:
undetectable		 6a4iB-3x3yA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4are COLLAGENASE G

(Hathewaya
histolytica) 		PF01752
(Peptidase_M9)
PF08453
(Peptidase_M9_N) 		4 ARG A 437
GLU A 444
TRP A 440
THR A 760
 None
 1.48A 6a4iB-4areA:
2.9		 6a4iB-4areA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c90 ALPHA-GLUCURONIDASE
GH115

(Bacteroides
ovatus) 		PF15979
(Glyco_hydro_115) 		4 GLU A 456
TRP A 459
THR A 450
PRO A 483
 None
 1.39A 6a4iB-4c90A:
2.0		 6a4iB-4c90A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ez5 CYCLIN-DEPENDENT
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		4 ARG A 186
TRP A 184
PRO A 148
PRO A 217
 None
 1.47A 6a4iB-4ez5A:
undetectable		 6a4iB-4ez5A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fin ETTA (YJJK) ABCF
FAMILY PROTEIN

(Escherichia
coli) 		PF00005
(ABC_tran)
PF12848
(ABC_tran_Xtn) 		4 ARG A 305
GLU A 307
THR A 300
PRO A 315
 None
 1.16A 6a4iB-4finA:
undetectable		 6a4iB-4finA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3

(Legionella
pneumophila) 		no annotation 4 GLU A 355
ARG A 307
THR A 303
PRO A 269
 None
 1.42A 6a4iB-4fyeA:
4.0		 6a4iB-4fyeA:
19.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hka TRYPTOPHAN
2,3-DIOXYGENASE

(Drosophila
melanogaster) 		PF03301
(Trp_dioxygenase) 		5 TRP A 192
ARG A 195
THR A 196
PRO A 197
PRO A 291
 None
 0.73A 6a4iB-4hkaA:
34.3		 6a4iB-4hkaA:
52.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpv S-ADENOSYLMETHIONINE
SYNTHASE

(Sulfolobus
solfataricus) 		PF01941
(AdoMet_Synthase) 		4 GLU A  23
ARG A 291
THR A 297
PRO A 298
 None
 1.32A 6a4iB-4hpvA:
undetectable		 6a4iB-4hpvA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3g BETA-GLUCOSIDASE

(Streptomyces
venezuelae) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 TRP A 545
THR A 547
PRO A 548
PRO A 479
 None
 1.43A 6a4iB-4i3gA:
undetectable		 6a4iB-4i3gA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iss ALLOPHANATE
HYDROLASE

(Kluyveromyces
lactis) 		PF01425
(Amidase) 		4 ARG A 200
ARG A 102
THR A 101
PRO A 100
 None
 1.27A 6a4iB-4issA:
undetectable		 6a4iB-4issA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iuw NEUTRAL
ENDOPEPTIDASE

(Lactobacillus
rhamnosus) 		PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N) 		4 ARG A 577
GLU A 525
THR A 574
PRO A 592
 None
 1.47A 6a4iB-4iuwA:
undetectable		 6a4iB-4iuwA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jrl PUTATIVE GLYCOSIDE
HYDROLASE

(Bacteroides
ovatus) 		PF13201
(PCMD) 		4 ARG A 175
THR A 180
PRO A 179
PRO A 164
 None
 1.45A 6a4iB-4jrlA:
undetectable		 6a4iB-4jrlA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lvq PHOSPHATE-BINDING
PROTEIN PSTS 3

(Mycobacterium
tuberculosis) 		PF12849
(PBP_like_2) 		4 ARG A 181
GLU A 180
TRP A 163
PRO A 239
 None
 1.44A 6a4iB-4lvqA:
undetectable		 6a4iB-4lvqA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mmh HEPARINASE III
PROTEIN

(Pedobacter
heparinus) 		PF07940
(Hepar_II_III)
PF16889
(Hepar_II_III_N) 		4 GLU A 544
THR A 442
PRO A 443
PRO A 597
 None
 1.28A 6a4iB-4mmhA:
undetectable		 6a4iB-4mmhA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oon PENICILLIN-BINDING
PROTEIN 1A

(Pseudomonas
aeruginosa) 		PF00905
(Transpeptidase)
PF00912
(Transgly)
PF17092
(PCB_OB) 		4 GLU A 652
ARG A 606
THR A 654
PRO A 655
 None
 1.26A 6a4iB-4oonA:
undetectable		 6a4iB-4oonA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p8e 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE

(Vibrio cholerae) 		PF00926
(DHBP_synthase) 		4 ARG A 151
GLU A  73
THR A  97
PRO A  83
 5RP  A 301 (-2.8A)
None
None
None
 1.03A 6a4iB-4p8eA:
undetectable		 6a4iB-4p8eA:
22.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4pw8 TRYPTOPHAN
2,3-DIOXYGENASE

(Homo sapiens) 		PF03301
(Trp_dioxygenase) 		4 TRP A 208
THR A 212
PRO A 213
PRO A 307
 None
 0.40A 6a4iB-4pw8A:
33.6		 6a4iB-4pw8A:
99.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r27 GLYCOSIDE HYDROLASE

(Microbacterium
sp. Gsoil167) 		PF00232
(Glyco_hydro_1) 		4 GLU A  93
ARG A 144
THR A 145
PRO A 131
 None
 1.00A 6a4iB-4r27A:
undetectable		 6a4iB-4r27A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgy ESTERASE

(uncultured
bacterium FLS12) 		PF00756
(Esterase) 		4 GLU A 245
TRP A 246
ARG A  61
THR A  62
 None
 1.07A 6a4iB-4rgyA:
undetectable		 6a4iB-4rgyA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rl1 TYPE I POLYKETIDE
SYNTHASE AVES 1

(Streptomyces
avermitilis) 		PF00698
(Acyl_transf_1) 		4 GLU A 284
ARG A 192
THR A 164
PRO A 165
 None
 1.37A 6a4iB-4rl1A:
undetectable		 6a4iB-4rl1A:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxl MOLYBDENUM ABC
TRANSPORTER,
PERIPLASMIC
MOLYBDENUM-BINDING
PROTEIN

(Vibrio cholerae) 		PF13531
(SBP_bac_11) 		4 GLU A  82
ARG A 216
PRO A 218
PRO A 145
 None
None
None
WO4  A 301 (-3.6A)
 1.21A 6a4iB-4rxlA:
undetectable		 6a4iB-4rxlA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4trq NUCLEAR MRNA EXPORT
PROTEIN THP1
26S PROTEASOME
COMPLEX SUBUNIT SEM1

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF01399
(PCI)
PF05160
(DSS1_SEM1) 		4 GLU C  61
TRP B 284
ARG B 288
PRO B 286
 None
 1.42A 6a4iB-4trqC:
undetectable		 6a4iB-4trqC:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wj3 ASPARTATE--TRNA(ASP/
ASN) LIGASE

(Pseudomonas
aeruginosa) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		4 GLU M 513
ARG M 170
THR M 172
PRO M 173
 None
 1.38A 6a4iB-4wj3M:
undetectable		 6a4iB-4wj3M:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgt FRQ-INTERACTING RNA
HELICASE

(Neurospora
crassa) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		4 GLU A 137
THR A 355
PRO A 356
PRO A 135
 None
 1.00A 6a4iB-4xgtA:
undetectable		 6a4iB-4xgtA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yc6 CYCLIN-DEPENDENT
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 ARG A 170
TRP A 168
PRO A 131
PRO A 202
 None
 1.39A 6a4iB-4yc6A:
undetectable		 6a4iB-4yc6A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yco TRNA-DIHYDROURIDINE
SYNTHASE C

(Escherichia
coli) 		PF01207
(Dus) 		4 ARG A  58
THR A  59
PRO A  60
PRO A  51
 None
 1.39A 6a4iB-4ycoA:
undetectable		 6a4iB-4ycoA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z42 UREASE SUBUNIT ALPHA

(Yersinia
enterocolitica) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		4 ARG C 407
THR C 536
PRO C 537
PRO C 300
 None
 1.33A 6a4iB-4z42C:
undetectable		 6a4iB-4z42C:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z81 EGF FAMILY
DOMAIN-CONTAINING
PROTEIN

(Toxoplasma
gondii) 		PF02430
(AMA-1)
PF07974
(EGF_2) 		4 GLU A 431
ARG A 476
THR A 474
PRO A 506
 None
 1.40A 6a4iB-4z81A:
undetectable		 6a4iB-4z81A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cvo WD REPEAT-CONTAINING
PROTEIN 48

(Homo sapiens) 		PF00400
(WD40) 		4 GLU A  72
ARG A 531
THR A 513
PRO A 514
 None
 1.36A 6a4iB-5cvoA:
undetectable		 6a4iB-5cvoA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cww NUCLEOPORIN NUP82

(Chaetomium
thermophilum) 		no annotation 4 ARG B 291
TRP B 292
PRO B 342
PRO B 294
 None
 1.45A 6a4iB-5cwwB:
undetectable		 6a4iB-5cwwB:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dld UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Burkholderia
vietnamiensis) 		PF02350
(Epimerase_2) 		4 ARG A 154
THR A 150
PRO A 149
PRO A 315
 None
 1.49A 6a4iB-5dldA:
undetectable		 6a4iB-5dldA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ehk LANTIBIOTIC
DEHYDRATASE

(Microbispora
corallina) 		PF04738
(Lant_dehydr_N)
PF14028
(Lant_dehydr_C) 		4 ARG A 736
THR A  17
PRO A  18
PRO A 781
 None
 1.31A 6a4iB-5ehkA:
undetectable		 6a4iB-5ehkA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eso 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE-1-CARBOXYLA
TE SYNTHASE

(Mycobacterium
tuberculosis) 		PF02776
(TPP_enzyme_N) 		4 ARG A  21
ARG A 424
THR A 425
PRO A 432
 None
 1.45A 6a4iB-5esoA:
undetectable		 6a4iB-5esoA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fi0 PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE-
DEPENDENT RAC
EXCHANGER 1
PROTEIN,PHOSPHATIDYL
INOSITOL
3,4,5-TRISPHOSPHATE-
DEPENDENT RAC
EXCHANGER 1 PROTEIN

(Homo sapiens) 		PF00169
(PH)
PF00621
(RhoGEF) 		4 ARG A  45
ARG A 212
THR A 213
PRO A 214
 PO4  A 501 (-2.8A)
PO4  A 501 (-3.7A)
None
None
 1.49A 6a4iB-5fi0A:
3.6		 6a4iB-5fi0A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8i UREA AMIDOLYASE

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF01425
(Amidase)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ARG A 200
ARG A 102
THR A 101
PRO A 100
 None
 1.24A 6a4iB-5i8iA:
undetectable		 6a4iB-5i8iA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jij ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE

(Mycolicibacterium
thermoresistibile) 		PF00982
(Glyco_transf_20) 		4 ARG A 324
ARG A 286
THR A 321
PRO A 322
 None
None
EDO  A 507 (-2.9A)
EDO  A 509 (-4.3A)
 1.49A 6a4iB-5jijA:
undetectable		 6a4iB-5jijA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1b WD REPEAT-CONTAINING
PROTEIN 48

(Homo sapiens) 		PF00400
(WD40)
PF11816
(DUF3337) 		4 GLU B  72
ARG B 531
THR B 513
PRO B 514
 None
 1.21A 6a4iB-5k1bB:
undetectable		 6a4iB-5k1bB:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lnk MITOCHONDRIAL
COMPLEX I, 18 KDA
SUBUNIT
MITOCHONDRIAL
COMPLEX I, B14
SUBUNIT

(Ovis aries;
Ovis aries) 		no annotation
no annotation 		4 ARG g 113
GLU c  27
PRO c  78
PRO c  26
 None
 1.29A 6a4iB-5lnkg:
undetectable		 6a4iB-5lnkg:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lti HEME DEPENDENT
OXIDATIVE
N-DEMETHYLASE

(Pseudomonas
mendocina) 		PF11927
(DUF3445) 		4 GLU A 240
TRP A 245
ARG A 234
PRO A 177
 None
 1.36A 6a4iB-5ltiA:
undetectable		 6a4iB-5ltiA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nzp D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Homo sapiens) 		no annotation 4 ARG B 155
THR B 207
PRO B 208
PRO B 176
 None
9EW  B 301 (-4.2A)
None
9EW  B 301 (-4.5A)
 1.27A 6a4iB-5nzpB:
undetectable		 6a4iB-5nzpB:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u38 LECTIN

(Platypodium
elegans) 		PF00139
(Lectin_legB) 		4 GLU A 129
TRP A 141
ARG A 156
PRO A 143
 MN  A 302 (-2.7A)
None
None
None
 1.50A 6a4iB-5u38A:
undetectable		 6a4iB-5u38A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uzh NAFOA.00085.B

(Naegleria
fowleri) 		PF16363
(GDP_Man_Dehyd) 		4 ARG A 334
THR A 336
PRO A 335
PRO A 187
 GDP  A 401 (-3.1A)
None
None
None
 1.32A 6a4iB-5uzhA:
undetectable		 6a4iB-5uzhA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vk4 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Neisseria
gonorrhoeae) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 GLU A 130
ARG A 225
THR A 224
PRO A 223
 None
 1.40A 6a4iB-5vk4A:
undetectable		 6a4iB-5vk4A:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wrt SOLUBLE INORGANIC
PYROPHOSPHATASE

(Toxoplasma
gondii) 		no annotation 4 GLU A 125
THR A 143
PRO A 102
PRO A 193
 MG  A 402 ( 4.3A)
None
None
None
 1.50A 6a4iB-5wrtA:
undetectable		 6a4iB-5wrtA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xe3 ENDORIBONUCLEASE
MAZF4

(Mycobacterium
tuberculosis) 		no annotation 4 ARG C   6
GLU C  83
THR C  88
PRO C  59
 None
 1.08A 6a4iB-5xe3C:
undetectable		 6a4iB-5xe3C:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4m MONOTREME LACTATION
PROTEIN

(Ornithorhynchus
anatinus) 		no annotation 4 ARG A 278
GLU A 239
ARG A 275
PRO A 273
 None
 1.42A 6a4iB-6b4mA:
1.6		 6a4iB-6b4mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f72 MTVAO615

(Thermothelomyces
thermophila) 		no annotation 4 ARG A 270
THR A 269
PRO A 268
PRO A 188
 None
 1.35A 6a4iB-6f72A:
undetectable		 6a4iB-6f72A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fsw RIBOSOME MATURATION
PROTEIN SDO1-LIKE
PROTEIN

(Archaeoglobus
fulgidus) 		no annotation 4 ARG A 129
GLU A 128
ARG A 126
PRO A 124
 None
 1.08A 6a4iB-6fswA:
undetectable		 6a4iB-6fswA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gpl GDP-MANNOSE 4,6
DEHYDRATASE

(Homo sapiens) 		no annotation 4 ARG B 325
THR B 327
PRO B 326
PRO B 178
 F7E  B 402 (-3.2A)
None
None
None
 1.29A 6a4iB-6gplB:
undetectable		 6a4iB-6gplB:
undetectable