SIMILAR PATTERNS OF AMINO ACIDS FOR 6A4I_A_TRPA403_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d5f E6AP HECT CATALYTIC
DOMAIN, E3 LIGASE

(Homo sapiens) 		PF00632
(HECT) 		4 ARG A 780
THR A 789
ILE A 605
PRO A 793
 None
 1.09A 6a4iA-1d5fA:
0.4		 6a4iA-1d5fA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gff BACTERIOPHAGE G4
CAPSID PROTEINS GPF,
GPG, GPJ

(Escherichia
virus G4) 		PF02306
(Phage_G) 		4 TRP 2 152
THR 2  47
ILE 2 157
PRO 2  83
 None
 1.00A 6a4iA-1gff2:
undetectable		 6a4iA-1gff2:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ii0 ARSENICAL
PUMP-DRIVING ATPASE

(Escherichia
coli) 		PF02374
(ArsA_ATPase) 		4 ARG A 434
THR A 480
PRO A 481
PRO A 450
 None
 1.10A 6a4iA-1ii0A:
0.1		 6a4iA-1ii0A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jr2 UROPORPHYRINOGEN-III
SYNTHASE

(Homo sapiens) 		PF02602
(HEM4) 		4 ARG A 230
THR A 228
PRO A 198
ILE A 224
 None
 0.99A 6a4iA-1jr2A:
undetectable		 6a4iA-1jr2A:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mro METHYL-COENZYME M
REDUCTASE

(Methanothermobacter
marburgensis) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		4 ARG A 471
GLU A 469
THR A 422
PRO A 495
 None
 1.04A 6a4iA-1mroA:
0.0		 6a4iA-1mroA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Escherichia
coli) 		PF00311
(PEPcase) 		4 GLU A 453
ARG A 265
THR A 264
ILE A 395
 None
 1.08A 6a4iA-1qb4A:
undetectable		 6a4iA-1qb4A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rc6 HYPOTHETICAL PROTEIN
YLBA

(Escherichia
coli) 		PF05899
(Cupin_3)
PF07883
(Cupin_2) 		4 ARG A1134
THR A1052
PRO A1053
ILE A1049
 None
 1.11A 6a4iA-1rc6A:
undetectable		 6a4iA-1rc6A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlp NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Saccharomyces
cerevisiae) 		PF04095
(NAPRTase) 		4 GLU A 176
ARG A 180
THR A  12
ILE A 216
 None
 1.06A 6a4iA-1vlpA:
0.0		 6a4iA-1vlpA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcg THIOGLUCOSIDASE

(Brevicoryne
brassicae) 		PF00232
(Glyco_hydro_1) 		4 GLU A 387
THR A 344
ILE A 348
PRO A 349
 None
 0.96A 6a4iA-1wcgA:
0.0		 6a4iA-1wcgA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y56 HYPOTHETICAL PROTEIN
PH1363

(Pyrococcus
horikoshii) 		PF07992
(Pyr_redox_2)
PF13510
(Fer2_4) 		4 GLU A 362
THR A 213
ILE A 316
PRO A 332
 None
ATP  A 801 (-4.3A)
None
None
 1.11A 6a4iA-1y56A:
0.0		 6a4iA-1y56A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yts YERSINIA PROTEIN
TYROSINE PHOSPHATASE

(Yersinia
enterocolitica) 		PF00102
(Y_phosphatase) 		4 ARG A 278
THR A 279
PRO A 280
ILE A 257
 SO4  A   2 (-4.1A)
None
None
None
 1.08A 6a4iA-1ytsA:
0.0		 6a4iA-1ytsA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azo MUTH

(Escherichia
coli) 		PF02976
(MutH) 		4 ARG A 184
THR A  93
ILE A  81
PRO A  82
 None
 1.06A 6a4iA-2azoA:
undetectable		 6a4iA-2azoA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bv5 TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 5

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 ARG A 425
THR A 368
PRO A 369
ILE A 346
 None
 0.91A 6a4iA-2bv5A:
undetectable		 6a4iA-2bv5A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmi UBIQUITIN-CONJUGATIN
G ENZYME VARIANT
MMS2

(Saccharomyces
cerevisiae) 		PF00179
(UQ_con) 		4 ARG B 117
THR B 122
PRO B 123
PRO B  84
 None
 1.06A 6a4iA-2gmiB:
undetectable		 6a4iA-2gmiB:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ARG A 549
ARG A 777
ILE A 564
PRO A 566
 None
 1.01A 6a4iA-2ogvA:
undetectable		 6a4iA-2ogvA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pge MENC

(Desulfotalea
psychrophila) 		PF13378
(MR_MLE_C) 		4 ARG A  97
THR A 334
ILE A 330
PRO A 292
 None
 1.13A 6a4iA-2pgeA:
undetectable		 6a4iA-2pgeA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjp CYTOCHROME B

(Rhodobacter
sphaeroides) 		PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B) 		4 ARG A 355
THR A 225
ILE A 424
PRO A  38
 None
 1.07A 6a4iA-2qjpA:
1.4		 6a4iA-2qjpA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v28 PHENYLALANINE-4-HYDR
OXYLASE

(Colwellia
psychrerythraea) 		PF00351
(Biopterin_H) 		4 ARG A 212
THR A 213
PRO A 214
ILE A 223
 SO4  A1268 (-3.0A)
None
None
None
 0.94A 6a4iA-2v28A:
undetectable		 6a4iA-2v28A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Homo sapiens) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		4 ARG A 559
ARG A 638
ILE A 657
PRO A 653
 None
 1.11A 6a4iA-2vxoA:
undetectable		 6a4iA-2vxoA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdf PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE

(Escherichia
coli) 		PF00391
(PEP-utilizers)
PF02896
(PEP-utilizers_C)
PF05524
(PEP-utilisers_N) 		4 ARG A 510
GLU A 504
PRO A 476
ILE A 485
 None
 1.11A 6a4iA-2xdfA:
2.1		 6a4iA-2xdfA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ze5 ISOPENTENYL
TRANSFERASE

(Agrobacterium
tumefaciens) 		PF01745
(IPT) 		4 GLU A  50
ARG A  57
THR A  56
ILE A  19
 None
 1.02A 6a4iA-2ze5A:
undetectable		 6a4iA-2ze5A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN

(Thermosynechococcus
vulcanus) 		PF00421
(PSII) 		4 TRP B 167
ARG B  68
PRO B  64
ILE B  80
 None
 0.91A 6a4iA-3a0hB:
undetectable		 6a4iA-3a0hB:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9i HOMOCITRATE SYNTHASE

(Thermus
thermophilus) 		PF00682
(HMGL-like) 		4 GLU A 193
ARG A  12
THR A  71
ILE A  91
 LYS  A 378 (-4.4A)
LYS  A 378 (-3.4A)
None
None
 1.01A 6a4iA-3a9iA:
undetectable		 6a4iA-3a9iA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bew MAJOR
HISTOCOMPATIBILITY
COMPLEX CLASS I
GLYCOPROTEIN
HAPLOTYPE B21

(Gallus gallus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 TRP A  59
THR A  54
ILE A  50
PRO A  45
 None
 1.14A 6a4iA-3bewA:
undetectable		 6a4iA-3bewA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cru GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME

(Schistosoma
japonicum) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 THR A  17
PRO A  16
ILE A  71
PRO A  56
 None
None
None
GSH  A 215 (-4.4A)
 1.03A 6a4iA-3cruA:
undetectable		 6a4iA-3cruA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d46 PUTATIVE GALACTONATE
DEHYDRATASE

(Salmonella
enterica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLU A 253
THR A  47
PRO A  48
ILE A  64
 None
 1.09A 6a4iA-3d46A:
undetectable		 6a4iA-3d46A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d4o DIPICOLINATE
SYNTHASE SUBUNIT A

(Bacillus
halodurans) 		PF01262
(AlaDh_PNT_C)
PF16924
(DpaA_N) 		4 TRP A  55
THR A  93
PRO A  94
ILE A  61
 None
 0.83A 6a4iA-3d4oA:
undetectable		 6a4iA-3d4oA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dl3 TELLURITE RESISTANCE
PROTEIN B

(Aliivibrio
fischeri) 		PF09313
(DUF1971) 		4 ARG A  14
THR A  16
PRO A  17
PRO A  25
 None
 1.03A 6a4iA-3dl3A:
undetectable		 6a4iA-3dl3A:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ed3 PROTEIN
DISULFIDE-ISOMERASE
MPD1

(Saccharomyces
cerevisiae) 		PF00085
(Thioredoxin) 		4 ARG A 290
THR A  49
PRO A 112
ILE A 153
 EDO  A2763 (-3.7A)
None
None
None
 0.90A 6a4iA-3ed3A:
undetectable		 6a4iA-3ed3A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ed3 PROTEIN
DISULFIDE-ISOMERASE
MPD1

(Saccharomyces
cerevisiae) 		PF00085
(Thioredoxin) 		4 GLU A 284
THR A  49
PRO A 112
ILE A 153
 EDO  A2763 (-3.5A)
None
None
None
 1.03A 6a4iA-3ed3A:
undetectable		 6a4iA-3ed3A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ekg MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Azotobacter
vinelandii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLU A 243
THR A  38
PRO A  39
ILE A  55
 None
 1.13A 6a4iA-3ekgA:
undetectable		 6a4iA-3ekgA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewd ADENOSINE DEAMINASE

(Plasmodium
vivax) 		PF00962
(A_deaminase) 		4 GLU A  40
THR A 316
PRO A 311
ILE A 278
 None
 1.01A 6a4iA-3ewdA:
undetectable		 6a4iA-3ewdA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxg RHAMNONATE
DEHYDRATASE

(Fusarium
graminearum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLU A 248
THR A  43
PRO A  44
ILE A  60
 None
 1.00A 6a4iA-3fxgA:
undetectable		 6a4iA-3fxgA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3goa 3-KETOACYL-COA
THIOLASE

(Salmonella
enterica) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 ARG A 362
GLU A 188
THR A 180
ILE A 210
 None
 1.01A 6a4iA-3goaA:
undetectable		 6a4iA-3goaA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2d CHEC-LIKE
SUPERFAMILY PROTEIN

(Shewanella
oneidensis) 		PF13690
(CheX) 		4 GLU A  91
THR A  97
ILE A  46
PRO A 116
 None
 0.97A 6a4iA-3h2dA:
undetectable		 6a4iA-3h2dA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hwc CHLOROPHENOL-4-MONOO
XYGENASE COMPONENT 2

(Burkholderia
cepacia) 		PF03241
(HpaB)
PF11794
(HpaB_N) 		4 THR A3224
PRO A3225
ILE A3263
PRO A3264
 None
 1.12A 6a4iA-3hwcA:
1.5		 6a4iA-3hwcA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3if6 OXA-46 OXACILLINASE

(Pseudomonas
aeruginosa) 		PF00905
(Transpeptidase) 		4 ARG C 216
THR C 239
PRO C 240
ILE C 237
 None
 1.09A 6a4iA-3if6C:
undetectable		 6a4iA-3if6C:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iuk UNCHARACTERIZED
PROTEIN

(Paenarthrobacter
aurescens) 		PF05960
(DUF885) 		4 ARG A 556
THR A  80
ILE A  14
PRO A  72
 None
 1.10A 6a4iA-3iukA:
undetectable		 6a4iA-3iukA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ivr PUTATIVE
LONG-CHAIN-FATTY-ACI
D COA LIGASE

(Rhodopseudomonas
palustris) 		PF00501
(AMP-binding) 		4 ARG A  90
PRO A 258
ILE A 263
PRO A 238
 None
 1.05A 6a4iA-3ivrA:
undetectable		 6a4iA-3ivrA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iyl VP1

(Aquareovirus C) 		PF06016
(Reovirus_L2) 		4 ARG W 129
TRP W  68
PRO W 199
ILE W 178
 None
 1.06A 6a4iA-3iylW:
undetectable		 6a4iA-3iylW:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF10

(Schizosaccharomyces
pombe) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF16004
(EFTUD2) 		4 THR B 217
PRO B 218
ILE B 145
PRO B 230
 None
 1.05A 6a4iA-3jb9B:
undetectable		 6a4iA-3jb9B:
16.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lml LIN1278 PROTEIN

(Listeria
innocua) 		PF04984
(Phage_sheath_1)
PF17481
(Phage_sheath_1N)
PF17482
(Phage_sheath_1C) 		4 ARG A 303
THR A 301
PRO A 302
ILE A 266
 None
 1.13A 6a4iA-3lmlA:
undetectable		 6a4iA-3lmlA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mcx SUSD SUPERFAMILY
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 GLU A 177
TRP A 108
ILE A 492
PRO A 175
 GOL  A  10 (-4.4A)
GOL  A  10 (-4.1A)
None
GOL  A  10 (-4.4A)
 1.12A 6a4iA-3mcxA:
1.8		 6a4iA-3mcxA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p1u SUSD HOMOLOG

(Parabacteroides
distasonis) 		PF12741
(SusD-like) 		4 GLU A  60
ARG A 372
ILE A 278
PRO A  65
 None
 1.14A 6a4iA-3p1uA:
2.2		 6a4iA-3p1uA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3plr UDP-GLUCOSE
6-DEHYDROGENASE

(Klebsiella
pneumoniae) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		4 ARG A 125
THR A 124
ILE A 119
PRO A 120
 None
 1.11A 6a4iA-3plrA:
undetectable		 6a4iA-3plrA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qc2 GLYCOSYL HYDROLASE

(Bacteroides
ovatus) 		PF04041
(Glyco_hydro_130) 		4 ARG A 319
THR A 318
PRO A 317
ILE A 247
 None
 0.97A 6a4iA-3qc2A:
undetectable		 6a4iA-3qc2A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9w GTPASE ERA

(Aquifex
aeolicus) 		PF01926
(MMR_HSR1)
PF07650
(KH_2) 		5 GLU A 209
ARG A 207
THR A 206
PRO A 211
ILE A 248
 G  B1530 ( 3.0A)
A  B1531 ( 3.6A)
A  B1531 ( 4.7A)
None
None
 1.47A 6a4iA-3r9wA:
undetectable		 6a4iA-3r9wA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rcy MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN

(Roseovarius sp.
TM1035) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ARG A 159
THR A 339
PRO A 340
PRO A  16
 None
 1.12A 6a4iA-3rcyA:
undetectable		 6a4iA-3rcyA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rq1 AMINOTRANSFERASE
CLASS I AND II

(Veillonella
parvula) 		PF00155
(Aminotran_1_2) 		4 TRP A 199
THR A 184
PRO A 185
ILE A 221
 None
 1.09A 6a4iA-3rq1A:
undetectable		 6a4iA-3rq1A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s1s RESTRICTION
ENDONUCLEASE BPUSI

(Bacillus
pumilus) 		PF02384
(N6_Mtase)
PF15516
(BpuSI_N) 		4 GLU A 204
ARG A 211
THR A 219
PRO A 218
 EDO  A 910 (-3.4A)
None
None
IOD  A 933 (-4.0A)
 1.06A 6a4iA-3s1sA:
undetectable		 6a4iA-3s1sA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6b METHIONINE
AMINOPEPTIDASE

(Plasmodium
falciparum) 		PF00557
(Peptidase_M24) 		4 ARG A 141
THR A 136
PRO A 179
ILE A 190
 None
 1.03A 6a4iA-3s6bA:
undetectable		 6a4iA-3s6bA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tp9 BETA-LACTAMASE AND
RHODANESE DOMAIN
PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF00581
(Rhodanese)
PF00753
(Lactamase_B) 		4 GLU A 165
THR A 121
PRO A 122
ILE A  57
 None
 0.92A 6a4iA-3tp9A:
undetectable		 6a4iA-3tp9A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wjs NADH OXIDASE

(Gluconobacter
oxydans) 		PF00724
(Oxidored_FMN) 		4 ARG A 261
PRO A 227
ILE A 235
PRO A 275
 None
 1.12A 6a4iA-3wjsA:
undetectable		 6a4iA-3wjsA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x3y PHENYLETHYLAMINE
OXIDASE

(Arthrobacter
globiformis) 		PF01179
(Cu_amine_oxid)
PF02728
(Cu_amine_oxidN3) 		4 ARG A 472
GLU A 451
PRO A 509
ILE A 443
 None
 1.10A 6a4iA-3x3yA:
undetectable		 6a4iA-3x3yA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ars HISTIDINE ACID
PHOSPHATASE

(Hafnia alvei) 		PF00328
(His_Phos_2) 		4 TRP A 321
THR A 330
PRO A 331
ILE A 310
 GOL  A1415 ( 3.8A)
GOL  A1415 ( 4.4A)
None
None
 0.84A 6a4iA-4arsA:
undetectable		 6a4iA-4arsA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4arv PHYTASE

(Yersinia
kristensenii) 		PF00328
(His_Phos_2) 		4 TRP A 321
THR A 330
PRO A 331
ILE A 310
 None
 0.92A 6a4iA-4arvA:
undetectable		 6a4iA-4arvA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e0f RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA

(Brucella
abortus) 		PF00677
(Lum_binding) 		4 ARG A  14
GLU A  27
PRO A  54
ILE A  35
 None
 1.05A 6a4iA-4e0fA:
undetectable		 6a4iA-4e0fA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g43 MHC CLASS I ALPHA
CHAIN 2

(Gallus gallus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 TRP A  59
THR A  54
ILE A  50
PRO A  45
 None
 1.07A 6a4iA-4g43A:
undetectable		 6a4iA-4g43A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g6c BETA-HEXOSAMINIDASE
1

(Burkholderia
cenocepacia) 		PF00933
(Glyco_hydro_3) 		4 ARG A 227
TRP A 235
ILE A 196
PRO A 173
 None
 1.03A 6a4iA-4g6cA:
undetectable		 6a4iA-4g6cA:
20.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hka TRYPTOPHAN
2,3-DIOXYGENASE

(Drosophila
melanogaster) 		PF03301
(Trp_dioxygenase) 		6 TRP A 192
ARG A 195
THR A 196
PRO A 197
ILE A 279
PRO A 291
 None
 0.74A 6a4iA-4hkaA:
35.9		 6a4iA-4hkaA:
52.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lxf TREHALOSE SYNTHASE

(Mycobacterium
tuberculosis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 TRP A 284
PRO A 334
ILE A 329
PRO A 309
 None
 1.12A 6a4iA-4lxfA:
undetectable		 6a4iA-4lxfA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mgg MUCONATE LACTONIZING
ENZYME

(Labrenzia
aggregata) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ARG A 232
THR A 234
ILE A 217
PRO A 220
 None
 1.08A 6a4iA-4mggA:
undetectable		 6a4iA-4mggA:
18.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4pw8 TRYPTOPHAN
2,3-DIOXYGENASE

(Homo sapiens) 		PF03301
(Trp_dioxygenase) 		5 TRP A 208
THR A 212
PRO A 213
ILE A 295
PRO A 307
 None
 0.42A 6a4iA-4pw8A:
34.3		 6a4iA-4pw8A:
99.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgy ESTERASE

(uncultured
bacterium FLS12) 		PF00756
(Esterase) 		4 GLU A 245
TRP A 246
ARG A  61
THR A  62
 None
 1.14A 6a4iA-4rgyA:
undetectable		 6a4iA-4rgyA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxl MOLYBDENUM ABC
TRANSPORTER,
PERIPLASMIC
MOLYBDENUM-BINDING
PROTEIN

(Vibrio cholerae) 		PF13531
(SBP_bac_11) 		4 GLU A  82
ARG A 216
PRO A 218
PRO A 145
 None
None
None
WO4  A 301 (-3.6A)
 0.88A 6a4iA-4rxlA:
undetectable		 6a4iA-4rxlA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udj UHGB_MP

(uncultured
organism) 		PF04041
(Glyco_hydro_130) 		4 ARG A 157
THR A 222
PRO A 223
ILE A 314
 None
 0.91A 6a4iA-4udjA:
undetectable		 6a4iA-4udjA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udj UHGB_MP

(uncultured
organism) 		PF04041
(Glyco_hydro_130) 		4 THR A 222
PRO A 223
ILE A 318
PRO A 315
 None
 0.94A 6a4iA-4udjA:
undetectable		 6a4iA-4udjA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ui1 HEMOJUVELIN

(Homo sapiens) 		PF06535
(RGM_N) 		4 GLU C  45
ARG C  92
THR C  90
ILE C 110
 None
 1.03A 6a4iA-4ui1C:
undetectable		 6a4iA-4ui1C:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wky BETA-KETOACYL
SYNTHASE

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 ARG A 240
ARG A  51
THR A  50
ILE A  78
 None
 1.08A 6a4iA-4wkyA:
undetectable		 6a4iA-4wkyA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wr4 GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME

(Schistosoma
japonicum) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 THR A  16
PRO A  15
ILE A  70
PRO A  55
 None
None
BYR  A  57 ( 3.8A)
GSH  A 301 (-4.5A)
 1.02A 6a4iA-4wr4A:
2.1		 6a4iA-4wr4A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xb6 ALPHA-D-RIBOSE
1-METHYLPHOSPHONATE
5-TRIPHOSPHATE
SYNTHASE SUBUNIT
PHNH
ALPHA-D-RIBOSE
1-METHYLPHOSPHONATE
5-TRIPHOSPHATE
SYNTHASE SUBUNIT
PHNI
ALPHA-D-RIBOSE
1-METHYLPHOSPHONATE
5-PHOSPHATE C-P
LYASE

(Escherichia
coli;
Escherichia
coli;
Escherichia
coli) 		PF05845
(PhnH)
PF05861
(PhnI)
PF06007
(PhnJ) 		4 ARG D  22
GLU B 118
THR C 181
PRO C 182
 None
 1.13A 6a4iA-4xb6D:
undetectable		 6a4iA-4xb6D:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgt FRQ-INTERACTING RNA
HELICASE

(Neurospora
crassa) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		4 GLU A 137
THR A 355
PRO A 356
PRO A 135
 None
 1.13A 6a4iA-4xgtA:
3.0		 6a4iA-4xgtA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yd8 PROTEIN PTHB1

(Homo sapiens) 		PF14727
(PHTB1_N) 		4 ARG A 278
THR A 303
PRO A 292
ILE A 305
 None
 0.97A 6a4iA-4yd8A:
undetectable		 6a4iA-4yd8A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yt2 H(2)-FORMING
METHYLENETETRAHYDROM
ETHANOPTERIN
DEHYDROGENASE-RELATE
D PROTEIN MJ1338

(Methanocaldococcus
jannaschii) 		PF03201
(HMD) 		4 GLU A  61
THR A 100
PRO A 101
ILE A 109
 None
 0.94A 6a4iA-4yt2A:
undetectable		 6a4iA-4yt2A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ze8 ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN
(AGROCINOPINES A AND
B)

(Agrobacterium
fabrum) 		PF00496
(SBP_bac_5) 		4 GLU A 513
ARG A 181
PRO A 205
ILE A 235
 PEG  A 605 ( 4.1A)
EDO  A 607 ( 4.1A)
None
None
 1.12A 6a4iA-4ze8A:
undetectable		 6a4iA-4ze8A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zlv ORNITHINE
AMINOTRANSFERASE,
MITOCHONDRIAL,
PUTATIVE

(Toxoplasma
gondii) 		PF00202
(Aminotran_3) 		4 ARG A 268
THR A 266
ILE A 226
PRO A 225
 None
 1.12A 6a4iA-4zlvA:
undetectable		 6a4iA-4zlvA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5auk FERREDOXIN-1

(Synechocystis
sp. PCC 6803) 		PF00111
(Fer2) 		4 GLU A  93
THR A   9
PRO A  10
PRO A  36
 BEN  A 109 (-4.5A)
BEN  A 105 ( 3.8A)
BEN  A 109 (-4.7A)
None
 0.91A 6a4iA-5aukA:
undetectable		 6a4iA-5aukA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B

(Homo sapiens) 		PF00233
(PDEase_I) 		4 ARG A 482
THR A 432
PRO A 431
ILE A 371
 None
None
None
4QJ  A 603 (-4.4A)
 1.11A 6a4iA-5b25A:
undetectable		 6a4iA-5b25A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cvo WD REPEAT-CONTAINING
PROTEIN 48

(Homo sapiens) 		PF00400
(WD40) 		4 GLU A  72
ARG A 531
THR A 513
PRO A 514
 None
 1.05A 6a4iA-5cvoA:
undetectable		 6a4iA-5cvoA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cww NUCLEOPORIN NUP82
NUCLEOPORIN NUP159

(Chaetomium
thermophilum;
Chaetomium
thermophilum) 		no annotation
no annotation 		4 ARG B 400
ARG C1447
THR C1450
ILE B 538
 None
 1.09A 6a4iA-5cwwB:
undetectable		 6a4iA-5cwwB:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5djq CBB3-TYPE CYTOCHROME
C OXIDASE SUBUNIT
CCON1
CBB3-TYPE CYTOCHROME
C OXIDASE SUBUNIT II

(Pseudomonas
stutzeri;
Pseudomonas
stutzeri) 		PF00115
(COX1)
PF02433
(FixO) 		4 GLU A 181
THR A 118
ILE B  61
PRO B  97
 CA  A 504 ( 4.6A)
None
None
None
 1.10A 6a4iA-5djqA:
undetectable		 6a4iA-5djqA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hca CALRETICULIN,CALRETI
CULIN

(Entamoeba
histolytica) 		no annotation 4 ARG C 136
THR C 137
PRO C 128
ILE C 179
 None
 1.13A 6a4iA-5hcaC:
undetectable		 6a4iA-5hcaC:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Saccharomyces
cerevisiae) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		4 ARG B 405
GLU B 245
ILE B 554
PRO B 551
 None
 1.09A 6a4iA-5ip9B:
undetectable		 6a4iA-5ip9B:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1b WD REPEAT-CONTAINING
PROTEIN 48

(Homo sapiens) 		PF00400
(WD40)
PF11816
(DUF3337) 		4 GLU B  72
ARG B 531
THR B 513
PRO B 514
 None
 1.00A 6a4iA-5k1bB:
undetectable		 6a4iA-5k1bB:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1c WD REPEAT-CONTAINING
PROTEIN 48

(Homo sapiens) 		PF00400
(WD40) 		4 GLU B  72
ARG B 531
THR B 513
PRO B 514
 None
 1.01A 6a4iA-5k1cB:
undetectable		 6a4iA-5k1cB:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nmi CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL

(Bos taurus) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 ARG A  92
GLU A  48
PRO A 170
ILE A 134
 None
 0.96A 6a4iA-5nmiA:
undetectable		 6a4iA-5nmiA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ol2 ACYL-COA
DEHYDROGENASE

(Clostridioides
difficile) 		no annotation 4 THR C 189
PRO C 190
ILE C 218
PRO C 219
 None
 0.97A 6a4iA-5ol2C:
1.8		 6a4iA-5ol2C:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t2u OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN

(Mycolicibacterium
smegmatis) 		PF13561
(adh_short_C2) 		4 ARG A 181
THR A 182
PRO A 183
ILE A  17
 None
NAP  A 301 (-2.7A)
NAP  A 301 ( 4.9A)
NAP  A 301 (-4.1A)
 1.13A 6a4iA-5t2uA:
undetectable		 6a4iA-5t2uA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t3a INTEGRASE

(Visna-maedi
virus) 		PF00665
(rve) 		4 TRP A 106
THR A 103
ILE A 137
PRO A 112
 None
 1.08A 6a4iA-5t3aA:
undetectable		 6a4iA-5t3aA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thm ESTERASE-6

(Drosophila
melanogaster) 		PF00135
(COesterase) 		4 ARG A 162
ARG A 200
ILE A 223
PRO A 281
 MLY  A 166 ( 4.0A)
None
None
None
 0.90A 6a4iA-5thmA:
undetectable		 6a4iA-5thmA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vm8 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Neisseria
gonorrhoeae) 		PF04452
(Methyltrans_RNA) 		4 TRP A 128
ARG A 127
ILE A 150
PRO A 106
 None
 0.98A 6a4iA-5vm8A:
undetectable		 6a4iA-5vm8A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9w DNA MISMATCH REPAIR
PROTEIN MUTS

(Neisseria
gonorrhoeae) 		no annotation 4 ARG A 346
THR A 114
ILE A 240
PRO A 248
 None
 1.09A 6a4iA-5x9wA:
0.8		 6a4iA-5x9wA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xt3 PHOSPHODIESTERASE
ACTING ON CYCLIC
DINUCLEOTIDES

(Staphylococcus
aureus) 		no annotation 4 GLU A 474
ARG A 508
THR A 509
ILE A 494
 None
 1.12A 6a4iA-5xt3A:
undetectable		 6a4iA-5xt3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi 40S RIBOSOMAL
PROTEIN SA
UNCHARACTERIZED
PROTEIN

(Trichomonas
vaginalis;
Trichomonas
vaginalis) 		PF00318
(Ribosomal_S2)
PF00333
(Ribosomal_S5)
PF03719
(Ribosomal_S5_C) 		4 ARG A 118
GLU A 116
PRO C  76
ILE C  82
 None
 1.13A 6a4iA-5xyiA:
undetectable		 6a4iA-5xyiA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yy8 INFLUENZA VIRUS
NS1A-BINDING PROTEIN

(Homo sapiens) 		no annotation 4 TRP A 178
ARG A 136
THR A 137
ILE A 153
 None
 1.08A 6a4iA-5yy8A:
undetectable		 6a4iA-5yy8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bhq IGH PROTEIN

(Mus musculus) 		no annotation 4 GLU A 376
PRO A 339
ILE A 336
PRO A 244
 None
 1.13A 6a4iA-6bhqA:
undetectable		 6a4iA-6bhqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en4 SPLICING FACTOR 3B
SUBUNIT 3

(Homo sapiens) 		no annotation 4 GLU A 576
THR A 538
PRO A 539
ILE A 544
 None
 0.64A 6a4iA-6en4A:
undetectable		 6a4iA-6en4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en4 SPLICING FACTOR 3B
SUBUNIT 3
SPLICING FACTOR 3B
SUBUNIT 5

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		4 THR A 784
PRO A 785
ILE B  55
PRO A 406
 None
 0.97A 6a4iA-6en4A:
undetectable		 6a4iA-6en4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fb3 TENEURIN-2

(Gallus gallus) 		no annotation 4 GLU A1886
TRP A1910
ILE A2573
PRO A1907
 None
 0.80A 6a4iA-6fb3A:
undetectable		 6a4iA-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g79 GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(O) SUBUNIT
ALPHA
5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		4 ARG S 161
THR S 162
PRO S 163
ILE A  28
 None
 1.02A 6a4iA-6g79S:
5.0		 6a4iA-6g79S:
undetectable