SIMILAR PATTERNS OF AMINO ACIDS FOR 5ZWR_B_9KLB402_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1buc BUTYRYL-COA
DEHYDROGENASE

(Megasphaera
elsdenii) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 SER A  95
TYR A  54
PHE A  55
TYR A  72
LEU A 114
 None
 1.21A 5zwrB-1bucA:
undetectable		 5zwrB-1bucA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ds6 RHO GDP-DISSOCIATION
INHIBITOR 2

(Homo sapiens) 		PF02115
(Rho_GDI) 		5 TYR B 107
SER B 105
ILE B 195
LEU B 193
LEU B  74
 None
 1.20A 5zwrB-1ds6B:
undetectable		 5zwrB-1ds6B:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h81 POLYAMINE OXIDASE

(Zea mays) 		PF01593
(Amino_oxidase) 		5 TYR A 329
ILE A 301
TYR A 328
LEU A 303
ALA A 367
 None
 1.40A 5zwrB-1h81A:
0.0		 5zwrB-1h81A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hno D3,D2-ENOYL COA
ISOMERASE ECI1

(Saccharomyces
cerevisiae) 		PF00378
(ECH_1) 		5 SER A  67
ILE A  59
TYR A  38
ALA A 123
LEU A 146
 None
 1.44A 5zwrB-1hnoA:
undetectable		 5zwrB-1hnoA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iqc DI-HEME PEROXIDASE

(Nitrosomonas
europaea) 		PF00034
(Cytochrom_C)
PF03150
(CCP_MauG) 		5 TYR A 242
TYR A 206
LEU A 233
ALA A 254
LEU A 251
 None
None
HEM  A 402 (-4.8A)
HEM  A 402 ( 4.0A)
None
 1.35A 5zwrB-1iqcA:
0.0		 5zwrB-1iqcA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfw CHITINASE B

(Arthrobacter
sp. TAD20) 		PF00704
(Glyco_hydro_18) 		5 ILE A 268
TYR A  23
LEU A 321
ALA A 240
LEU A 263
 None
 1.36A 5zwrB-1kfwA:
0.0		 5zwrB-1kfwA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ktw IOTA-CARRAGEENASE

(Alteromonas sp.
ATCC 43554) 		PF12708
(Pectate_lyase_3) 		5 SER A 201
PHE A 231
ILE A 221
TYR A 170
ALA A 226
 None
 1.41A 5zwrB-1ktwA:
undetectable		 5zwrB-1ktwA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kwm PROCARBOXYPEPTIDASE
B

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		5 PHE A  78
ILE A 195
LEU A 271
ALA A 296
LEU A 230
 None
 1.01A 5zwrB-1kwmA:
0.0		 5zwrB-1kwmA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 SER A 123
PHE A1232
ILE A 156
LEU A 157
ALA A 142
 None
 1.12A 5zwrB-1n5xA:
0.0		 5zwrB-1n5xA:
15.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ni6 HEME OXYGENASE 1

(Homo sapiens) 		PF01126
(Heme_oxygenase) 		5 TYR A  58
ILE A  57
LEU A 118
ALA A 133
LEU A 129
 None
 1.43A 5zwrB-1ni6A:
undetectable		 5zwrB-1ni6A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nsa PROCARBOXYPEPTIDASE
B

(Sus scrofa) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		5 PHE A  78
ILE A 195
LEU A 271
ALA A 296
LEU A 230
 None
 1.11A 5zwrB-1nsaA:
undetectable		 5zwrB-1nsaA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nzj HYPOTHETICAL PROTEIN
YADB

(Escherichia
coli) 		PF00749
(tRNA-synt_1c) 		5 ILE A   7
TYR A 205
ARG A  43
LEU A  41
LEU A  76
 None
 1.32A 5zwrB-1nzjA:
undetectable		 5zwrB-1nzjA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1otk PHENYLACETIC ACID
DEGRADATION PROTEIN
PAAC

(Escherichia
coli) 		PF05138
(PaaA_PaaC) 		5 ILE A 101
LEU A 170
HIS A 105
ALA A 107
LEU A 192
 None
 0.99A 5zwrB-1otkA:
undetectable		 5zwrB-1otkA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ovm INDOLE-3-PYRUVATE
DECARBOXYLASE

(Enterobacter
cloacae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 SER A 524
PHE A 372
ILE A 430
LEU A 369
LEU A 510
 None
 1.13A 5zwrB-1ovmA:
undetectable		 5zwrB-1ovmA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p5s RAS
GTPASE-ACTIVATING-LI
KE PROTEIN RNG2

(Schizosaccharomyces
pombe) 		PF00307
(CH) 		5 PHE A 187
TYR A  40
LEU A 190
ALA A  47
LEU A 156
 None
 1.42A 5zwrB-1p5sA:
undetectable		 5zwrB-1p5sA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1paq TRANSLATION
INITIATION FACTOR
EIF-2B EPSILON
SUBUNIT

(Saccharomyces
cerevisiae) 		PF02020
(W2) 		5 PHE A 622
ILE A 589
LEU A 635
ALA A 658
LEU A 659
 None
 1.38A 5zwrB-1paqA:
undetectable		 5zwrB-1paqA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qf6 THREONYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF00587
(tRNA-synt_2b)
PF02824
(TGS)
PF03129
(HGTP_anticodon)
PF07973
(tRNA_SAD) 		5 TYR A  14
ILE A   4
LEU A   6
ALA A  24
LEU A  31
 None
 1.41A 5zwrB-1qf6A:
undetectable		 5zwrB-1qf6A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ttw SECRETION CHAPERONE

(Yersinia pestis) 		PF05932
(CesT) 		5 PHE A  11
ILE A  20
LEU A   8
ALA A  50
LEU A  48
 None
 1.34A 5zwrB-1ttwA:
undetectable		 5zwrB-1ttwA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1um1 KIAA1849 PROTEIN

(Homo sapiens) 		PF00595
(PDZ) 		5 PHE A  90
ILE A  81
LEU A  25
ALA A  49
LEU A  43
 None
 1.42A 5zwrB-1um1A:
undetectable		 5zwrB-1um1A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w3i 2-KETO-3-DEOXY
GLUCONATE ALDOLASE

(Sulfolobus
solfataricus) 		PF00701
(DHDPS) 		5 SER A 123
ILE A  93
LEU A  59
HIS A 125
ALA A  85
 GOL  A1297 ( 4.8A)
None
None
None
None
 1.22A 5zwrB-1w3iA:
undetectable		 5zwrB-1w3iA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1woc PRIMOSOMAL
REPLICATION PROTEIN
N

(Escherichia
coli) 		PF00436
(SSB) 		5 PHE A  29
ILE A  72
LEU A  31
ALA A  94
LEU A  92
 None
 1.12A 5zwrB-1wocA:
undetectable		 5zwrB-1wocA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y79 PEPTIDYL-DIPEPTIDASE
DCP

(Escherichia
coli) 		PF01432
(Peptidase_M3) 		5 SER 1  64
LYS 1  38
ILE 1 138
LEU 1 134
LEU 1 435
 None
 1.41A 5zwrB-1y791:
undetectable		 5zwrB-1y791:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zli CARBOXYPEPTIDASE B

(Homo sapiens) 		PF00246
(Peptidase_M14) 		5 PHE A  78
ILE A 195
LEU A 271
ALA A 296
LEU A 230
 None
 1.00A 5zwrB-1zliA:
undetectable		 5zwrB-1zliA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ccz PRIMOSOMAL
REPLICATION PROTEIN
N

(Escherichia
coli) 		PF00436
(SSB) 		5 PHE A  29
ILE A  72
LEU A  31
ALA A  94
LEU A  92
 None
 1.12A 5zwrB-2cczA:
undetectable		 5zwrB-2cczA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fim TUBBY RELATED
PROTEIN 1

(Homo sapiens) 		PF01167
(Tub) 		5 SER A 480
TYR A 355
LEU A 469
ALA A 478
LEU A 463
 None
 1.10A 5zwrB-2fimA:
undetectable		 5zwrB-2fimA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fus FUMARASE C

(Escherichia
coli) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		5 SER A  43
ILE A 366
LEU A 274
ALA A 155
LEU A 156
 None
 1.34A 5zwrB-2fusA:
undetectable		 5zwrB-2fusA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hcb CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA

(Aquifex
aeolicus) 		PF00308
(Bac_DnaA)
PF08299
(Bac_DnaA_C) 		5 SER A 146
TYR A 171
ILE A 198
ALA A 148
LEU A 185
 None
 1.40A 5zwrB-2hcbA:
undetectable		 5zwrB-2hcbA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2if4 ATFKBP42

(Arabidopsis
thaliana) 		PF00254
(FKBP_C)
PF13181
(TPR_8) 		5 TYR A  74
ILE A  95
TYR A 151
ALA A 110
LEU A  99
 None
 1.21A 5zwrB-2if4A:
undetectable		 5zwrB-2if4A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jrz HISTONE DEMETHYLASE
JARID1C

(Homo sapiens) 		PF01388
(ARID) 		5 SER A  46
TYR A  15
ILE A  19
LEU A  30
LEU A  40
 None
 1.31A 5zwrB-2jrzA:
undetectable		 5zwrB-2jrzA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jzk CYANOVIRIN-N HOMOLOG

(Tuber borchii) 		PF08881
(CVNH) 		5 SER A   7
ILE A  93
LEU A  37
ALA A  10
LEU A  64
 None
 1.43A 5zwrB-2jzkA:
undetectable		 5zwrB-2jzkA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nty EMB|CAB41934.1

(Arabidopsis
thaliana) 		PF03759
(PRONE) 		5 PHE A 240
ILE A 226
LEU A 255
ALA A 295
LEU A 299
 None
 1.24A 5zwrB-2ntyA:
undetectable		 5zwrB-2ntyA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qmw PREPHENATE
DEHYDRATASE

(Staphylococcus
aureus) 		PF00800
(PDT) 		5 SER A 237
PHE A 188
ILE A 247
ALA A 235
LEU A 214
 None
 1.34A 5zwrB-2qmwA:
undetectable		 5zwrB-2qmwA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x8u SERINE
PALMITOYLTRANSFERASE

(Sphingomonas
wittichii) 		PF00155
(Aminotran_1_2) 		5 SER A 378
ILE A  48
LEU A 352
HIS A 377
LEU A 386
 None
 1.41A 5zwrB-2x8uA:
undetectable		 5zwrB-2x8uA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zu6 PROGRAMMED CELL
DEATH PROTEIN 4

(Homo sapiens) 		PF02847
(MA3) 		5 ILE B 396
TYR B 405
LEU B 351
ALA B 367
LEU B 335
 None
 1.39A 5zwrB-2zu6B:
undetectable		 5zwrB-2zu6B:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3n DIHYDROOROTATE
DEHYDROGENASE

(Trypanosoma
cruzi) 		PF01180
(DHO_dh) 		5 TYR A 159
PHE A  78
ILE A 100
LEU A  98
ALA A 116
 TYR  A 159 ( 1.3A)
PHE  A  78 ( 1.3A)
ILE  A 100 ( 0.6A)
LEU  A  98 ( 0.6A)
ALA  A 116 ( 0.0A)
 1.37A 5zwrB-3c3nA:
undetectable		 5zwrB-3c3nA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5n TUBBY-RELATED
PROTEIN 1

(Homo sapiens) 		PF01167
(Tub) 		5 SER A 480
TYR A 355
LEU A 469
ALA A 478
LEU A 463
 None
 1.10A 5zwrB-3c5nA:
undetectable		 5zwrB-3c5nA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cbg O-METHYLTRANSFERASE

(Synechocystis
sp. PCC 6803) 		PF01596
(Methyltransf_3) 		5 PHE A 141
ILE A  44
TYR A 149
LEU A  52
LEU A 216
 None
SAH  A 301 (-3.5A)
None
None
None
 1.42A 5zwrB-3cbgA:
undetectable		 5zwrB-3cbgA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cji POLYPROTEIN

(Senecavirus A) 		no annotation 5 TYR A 111
TYR A 241
PHE A 119
LEU A 191
ALA A 114
 None
 1.20A 5zwrB-3cjiA:
undetectable		 5zwrB-3cjiA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctt MALTASE-GLUCOAMYLASE

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		5 SER A 622
ILE A 629
LEU A 727
HIS A 625
LEU A 720
 None
None
None
SO4  A4001 (-3.9A)
None
 1.42A 5zwrB-3cttA:
undetectable		 5zwrB-3cttA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dnh UNCHARACTERIZED
PROTEIN ATU2129

(Agrobacterium
fabrum) 		PF13883
(Pyrid_oxidase_2) 		5 PHE A  69
ILE A  87
LEU A 147
ALA A  40
LEU A  91
 None
 1.37A 5zwrB-3dnhA:
undetectable		 5zwrB-3dnhA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF14710
(Nitr_red_alph_N) 		5 SER A1057
PHE A 431
LEU A 455
ALA A 351
LEU A 342
 None
 1.31A 5zwrB-3egwA:
undetectable		 5zwrB-3egwA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ehm SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12741
(SusD-like) 		5 TYR A 277
TYR A  64
ILE A  62
LEU A 462
LEU A 409
 None
 1.31A 5zwrB-3ehmA:
undetectable		 5zwrB-3ehmA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fkq NTRC-LIKE TWO-DOMAIN
PROTEIN

([Eubacterium]
rectale) 		PF13614
(AAA_31) 		5 PHE A 129
ILE A 352
HIS A 149
ALA A 144
LEU A 343
 None
 1.42A 5zwrB-3fkqA:
undetectable		 5zwrB-3fkqA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5k RIBOSOME-INACTIVATIN
G PROTEIN
PD-L1/PD-L2

(Phytolacca
dioica) 		PF00161
(RIP) 		5 ILE A   4
TYR A  16
ARG A  24
ALA A 177
LEU A 250
 None
 1.25A 5zwrB-3h5kA:
undetectable		 5zwrB-3h5kA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibg ATPASE, SUBUNIT OF
THE GET COMPLEX

(Aspergillus
fumigatus) 		PF02374
(ArsA_ATPase) 		5 SER A  43
ILE A  60
LEU A  58
ALA A  47
LEU A  89
 None
 1.38A 5zwrB-3ibgA:
undetectable		 5zwrB-3ibgA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3is6 PUTATIVE PERMEASE
PROTEIN, ABC
TRANSPORTER

(Porphyromonas
gingivalis) 		PF12704
(MacB_PCD) 		5 TYR A 224
PHE A 132
ILE A 196
LEU A 190
ALA A 124
 None
 1.28A 5zwrB-3is6A:
undetectable		 5zwrB-3is6A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k8k ALPHA-AMYLASE, SUSG

(Bacteroides
thetaiotaomicron) 		PF00128
(Alpha-amylase) 		5 SER A  63
TYR A 427
ILE A 489
TYR A 147
HIS A 526
 None
 1.28A 5zwrB-3k8kA:
undetectable		 5zwrB-3k8kA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lao ENOYL-COA
HYDRATASE/ISOMERASE

(Pseudomonas
aeruginosa) 		PF00378
(ECH_1) 		5 PHE A 154
ILE A 118
LEU A 122
ALA A 178
LEU A 184
 None
 1.38A 5zwrB-3laoA:
undetectable		 5zwrB-3laoA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lfu DNA HELICASE II

(Escherichia
coli) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		5 TYR A 254
ILE A 253
LEU A 598
ALA A 562
LEU A 353
 None
 1.44A 5zwrB-3lfuA:
undetectable		 5zwrB-3lfuA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lk7 UDP-N-ACETYLMURAMOYL
ALANINE--D-GLUTAMATE
LIGASE

(Streptococcus
agalactiae) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 PHE A 362
ILE A 334
LEU A 365
ALA A 353
LEU A 351
 None
 1.30A 5zwrB-3lk7A:
undetectable		 5zwrB-3lk7A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m33 UNCHARACTERIZED
PROTEIN

(Deinococcus
radiodurans) 		no annotation 5 PHE A 135
ILE A 122
LEU A 125
ALA A  52
LEU A  50
 None
 1.11A 5zwrB-3m33A:
undetectable		 5zwrB-3m33A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ns1 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos taurus) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		5 TYR B 411
PHE B 327
ILE B 297
LEU B 312
HIS B 292
 None
 1.33A 5zwrB-3ns1B:
undetectable		 5zwrB-3ns1B:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntx CYTOPLASMIC
L-ASPARAGINASE I

(Yersinia pestis) 		PF00710
(Asparaginase) 		5 SER A 222
TYR A 218
ILE A 217
LEU A 239
LEU A 230
 None
 1.31A 5zwrB-3ntxA:
undetectable		 5zwrB-3ntxA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qc5 PLATELET BINDING
PROTEIN GSPB

(Streptococcus
gordonii) 		no annotation 5 TYR X 391
ILE X 264
ARG X 358
LEU X 359
HIS X 257
 None
 1.44A 5zwrB-3qc5X:
undetectable		 5zwrB-3qc5X:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3se4 INTERFERON OMEGA-1

(Homo sapiens) 		PF00143
(Interferon) 		5 SER B 153
TYR B 125
PHE B 126
ILE B 129
LEU B  69
 None
 1.20A 5zwrB-3se4B:
undetectable		 5zwrB-3se4B:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6s CERJ

(Streptomyces
tendae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 SER A  82
TYR A 302
ILE A 123
LEU A 173
LEU A  78
 None
 1.44A 5zwrB-3t6sA:
undetectable		 5zwrB-3t6sA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ux9 INTERFERON
ALPHA-1/13

(Homo sapiens) 		PF00143
(Interferon) 		5 SER A 151
TYR A 123
PHE A 124
ILE A 127
LEU A  67
 None
 1.21A 5zwrB-3ux9A:
undetectable		 5zwrB-3ux9A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wew HTDX DEHYDRATASE

(Mycobacterium
tuberculosis) 		PF01575
(MaoC_dehydratas) 		5 TYR A 156
ILE A 153
TYR A  19
ALA A 191
LEU A 146
 None
 1.24A 5zwrB-3wewA:
undetectable		 5zwrB-3wewA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyt ESTERASE A

(Paenarthrobacter
nitroguajacolicus) 		PF00144
(Beta-lactamase) 		5 SER A  59
LYS A  62
TYR A 148
ALA A 325
LEU A 229
 None
 1.10A 5zwrB-3zytA:
30.9		 5zwrB-3zytA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyt ESTERASE A

(Paenarthrobacter
nitroguajacolicus) 		PF00144
(Beta-lactamase) 		5 SER A  59
LYS A  62
TYR A 148
PHE A 295
ALA A 325
 None
 1.31A 5zwrB-3zytA:
30.9		 5zwrB-3zytA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyt ESTERASE A

(Paenarthrobacter
nitroguajacolicus) 		PF00144
(Beta-lactamase) 		5 SER A  59
TYR A 148
ILE A 153
ALA A 245
LEU A 242
 None
 1.25A 5zwrB-3zytA:
30.9		 5zwrB-3zytA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bvx EUKARYOTIC
TRANSLATION
ELONGATION FACTOR 1
EPSILON-1

(Homo sapiens) 		PF00043
(GST_C) 		5 ILE B 118
TYR B  59
LEU B  10
ALA B  55
LEU B  16
 None
 1.42A 5zwrB-4bvxB:
undetectable		 5zwrB-4bvxB:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cp2 EPITHELIAL ADHESIN 9

([Candida]
glabrata) 		PF10528
(GLEYA) 		5 TYR A 162
PHE A 173
ILE A 168
LEU A  67
LEU A 177
 None
 1.40A 5zwrB-4cp2A:
undetectable		 5zwrB-4cp2A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g79 SPINDLE ASSEMBLY
ABNORMAL PROTEIN 6

(Caenorhabditis
elegans) 		PF16531
(SAS-6_N) 		5 PHE A  53
ILE A  38
TYR A  74
LEU A  36
LEU A 120
 None
 1.27A 5zwrB-4g79A:
undetectable		 5zwrB-4g79A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4geu SPINDLE ASSEMBLY
ABNORMAL PROTEIN 6

(Caenorhabditis
elegans) 		PF16531
(SAS-6_N) 		5 PHE A  53
ILE A  38
TYR A  74
LEU A  36
LEU A 148
 None
 1.15A 5zwrB-4geuA:
undetectable		 5zwrB-4geuA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gni PUTATIVE HEAT SHOCK
PROTEIN

(Chaetomium
thermophilum) 		PF00012
(HSP70) 		5 TYR A 194
TYR A 229
ILE A 207
ALA A 193
LEU A 389
 None
 0.94A 5zwrB-4gniA:
undetectable		 5zwrB-4gniA:
22.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ivi CARBOXYLESTERASE

(uncultured
bacterium) 		PF00144
(Beta-lactamase) 		6 TYR A  99
SER A 100
LYS A 103
TYR A 172
TYR A 218
ALA A 384
 None
 0.37A 5zwrB-4iviA:
48.0		 5zwrB-4iviA:
30.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ivi CARBOXYLESTERASE

(uncultured
bacterium) 		PF00144
(Beta-lactamase) 		5 TYR A  99
SER A 100
LYS A 103
TYR A 218
ALA A 384
 None
 1.32A 5zwrB-4iviA:
48.0		 5zwrB-4iviA:
30.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j9u TRK SYSTEM POTASSIUM
UPTAKE PROTEIN TRKH

(Vibrio
parahaemolyticus) 		PF02386
(TrkH) 		5 TYR A 300
SER A 302
TYR A 236
ALA A 306
LEU A 294
 None
 1.41A 5zwrB-4j9uA:
undetectable		 5zwrB-4j9uA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jo3 MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY R20 HEAVY
CHAIN

(Oryctolagus
cuniculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 TYR H 100
TYR H  34
PHE H  58
ILE H  56
TYR H 100
 None
 1.44A 5zwrB-4jo3H:
undetectable		 5zwrB-4jo3H:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jz6 SALICYLALDEHYDE
DEHYDROGENASE NAHF

(Pseudomonas
putida) 		PF00171
(Aldedh) 		5 PHE A 108
ILE A 159
LEU A 163
ALA A 191
LEU A  67
 None
 1.09A 5zwrB-4jz6A:
undetectable		 5zwrB-4jz6A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kvo N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1

(Schizosaccharomyces
pombe) 		PF12569
(NARP1) 		5 SER A 123
TYR A 546
PHE A 538
ALA A 119
LEU A 138
 CL  A 802 (-3.0A)
None
CL  A 802 (-4.5A)
None
None
 1.36A 5zwrB-4kvoA:
undetectable		 5zwrB-4kvoA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lcm TRANSESTERASE

(Aspergillus
terreus) 		PF00144
(Beta-lactamase) 		5 SER A  76
LYS A  79
TYR A 146
PHE A 148
TYR A 188
 None
 0.75A 5zwrB-4lcmA:
37.1		 5zwrB-4lcmA:
26.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lun NONSENSE-MEDIATED
MRNA DECAY PROTEIN 2

(Saccharomyces
cerevisiae) 		PF02854
(MIF4G) 		5 PHE U 104
ILE U  72
ARG U 103
LEU U 100
ALA U  63
 None
 1.37A 5zwrB-4lunU:
undetectable		 5zwrB-4lunU:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4miv N-SULPHOGLUCOSAMINE
SULPHOHYDROLASE

(Homo sapiens) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		5 TYR A 138
PHE A 136
ILE A 121
ARG A 117
LEU A 173
 None
 1.28A 5zwrB-4mivA:
undetectable		 5zwrB-4mivA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE

(Geobacter
sulfurreducens) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		6 TYR A 974
PHE A 978
ILE A 757
TYR A 617
LEU A 726
ALA A 665
 None
 1.35A 5zwrB-4nmeA:
undetectable		 5zwrB-4nmeA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oog RIBONUCLEASE 3

(Saccharomyces
cerevisiae) 		PF00035
(dsrm)
PF00636
(Ribonuclease_3) 		5 PHE C 319
ILE C 323
TYR C 288
LEU C 248
LEU C 275
 None
 1.36A 5zwrB-4oogC:
undetectable		 5zwrB-4oogC:
20.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6b EST-Y29

(metagenome) 		PF00144
(Beta-lactamase) 		10 TYR A  57
SER A  58
LYS A  61
TYR A 123
PHE A 125
ILE A 141
TYR A 170
HIS A 261
ALA A 348
LEU A 370
 None
 0.53A 5zwrB-4p6bA:
70.7		 5zwrB-4p6bA:
99.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6b EST-Y29

(metagenome) 		PF00144
(Beta-lactamase) 		6 TYR A  57
SER A  58
LYS A  61
TYR A 170
ALA A 348
LEU A 370
 None
 1.33A 5zwrB-4p6bA:
70.7		 5zwrB-4p6bA:
99.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV

(Bacteroides
ovatus) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		5 TYR A 123
PHE A 114
ILE A  84
LEU A  96
ALA A  93
 None
 1.41A 5zwrB-4q1vA:
undetectable		 5zwrB-4q1vA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6k BNR/ASP-BOX REPEAT
PROTEIN

(Bacteroides
caccae) 		PF13088
(BNR_2)
PF14873
(BNR_assoc_N) 		5 SER A 136
ILE A 162
LEU A  63
ALA A 149
LEU A  73
 None
 1.31A 5zwrB-4q6kA:
undetectable		 5zwrB-4q6kA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd3 L-AMINO ACID LIGASE

(Bacillus
subtilis) 		PF13535
(ATP-grasp_4) 		5 PHE A 342
ILE A 339
LEU A 403
ALA A 378
LEU A 332
 None
 1.40A 5zwrB-4wd3A:
undetectable		 5zwrB-4wd3A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y85 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 8

(Homo sapiens) 		PF00069
(Pkinase) 		5 SER A  92
ILE A 169
LEU A 205
ALA A  88
LEU A  84
 None
 1.28A 5zwrB-4y85A:
undetectable		 5zwrB-4y85A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysw XANTHINE
DEHYDROGENASE/OXIDAS
E

(Rattus
norvegicus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 SER A 122
PHE A1232
ILE A 155
LEU A 156
ALA A 141
 None
 1.07A 5zwrB-4yswA:
undetectable		 5zwrB-4yswA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa6 VANADIUM-DEPENDENT
BROMOPEROXIDASE 2

(Ascophyllum
nodosum) 		no annotation 5 PHE A 580
ILE A 588
TYR A 583
LEU A 590
ALA A 552
 None
 1.35A 5zwrB-5aa6A:
undetectable		 5zwrB-5aa6A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci5 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1

(Pseudothermotoga
lettingae) 		PF13416
(SBP_bac_8) 		5 TYR A  48
PHE A  44
LEU A  22
ALA A 316
LEU A  78
 None
 1.39A 5zwrB-5ci5A:
undetectable		 5zwrB-5ci5A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7h IPT/TIG
DOMAIN-CONTAINING
PROTEIN BACOVA_02650

(Bacteroides
ovatus) 		PF01833
(TIG) 		5 SER A 370
ILE A 408
TYR A 322
LEU A 391
ALA A 372
 None
 1.36A 5zwrB-5e7hA:
undetectable		 5zwrB-5e7hA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fku DNA POLYMERASE III
SUBUNIT ALPHA

(Escherichia
coli) 		PF01336
(tRNA_anti-codon)
PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		5 TYR A 681
PHE A 651
LEU A 623
ALA A 633
LEU A 634
 None
 1.43A 5zwrB-5fkuA:
undetectable		 5zwrB-5fkuA:
16.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fn1 COAT PROTEIN

(Pepino mosaic
virus) 		PF00286
(Flexi_CP) 		5 TYR A  86
ARG A 109
LEU A 112
ALA A  85
LEU A  97
 None
 1.41A 5zwrB-5fn1A:
undetectable		 5zwrB-5fn1A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdf HYDROLASE

(Streptomyces
flocculus) 		no annotation 5 PHE B 256
ILE B 221
LEU B 310
ALA B 102
LEU B 186
 None
 1.42A 5zwrB-5hdfB:
undetectable		 5zwrB-5hdfB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikz OXALATE BIOSYNTHETIC
COMPONENT 1

(Burkholderia
thailandensis) 		PF05853
(BKACE) 		5 TYR A 568
ILE A 605
ARG A 644
LEU A 575
LEU A 641
 None
 1.37A 5zwrB-5ikzA:
undetectable		 5zwrB-5ikzA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1q CARBOXYPEPTIDASE B

(Sus scrofa) 		PF00246
(Peptidase_M14) 		5 PHE A  78
ILE A 195
LEU A 271
ALA A 296
LEU A 230
 None
 1.09A 5zwrB-5j1qA:
undetectable		 5zwrB-5j1qA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6q CELL WALL BINDING
PROTEIN CWP8

(Clostridioides
difficile) 		PF04122
(CW_binding_2) 		5 SER A 307
ILE A 319
LEU A 321
ALA A 303
LEU A 346
 None
 1.34A 5zwrB-5j6qA:
undetectable		 5zwrB-5j6qA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mb9 PUTATIVE HEAT SHOCK
PROTEIN

(Chaetomium
thermophilum) 		PF00012
(HSP70) 		5 TYR A 194
TYR A 229
ILE A 207
ALA A 193
LEU A 389
 None
 1.04A 5zwrB-5mb9A:
undetectable		 5zwrB-5mb9A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfn JMJC
DOMAIN-CONTAINING
PROTEIN 7

(Homo sapiens) 		no annotation 5 TYR A 253
SER A 252
ILE A 238
LEU A 177
ALA A 256
 None
 1.39A 5zwrB-5nfnA:
undetectable		 5zwrB-5nfnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5okt CASEIN KINASE I
ISOFORM DELTA

(Homo sapiens) 		no annotation 5 TYR C  56
ILE C 148
LEU C 135
ALA C  36
LEU C  84
 9XK  C 301 (-4.3A)
9XK  C 301 ( 3.6A)
9XK  C 301 (-4.6A)
9XK  C 301 ( 3.7A)
9XK  C 301 (-3.7A)
 1.40A 5zwrB-5oktC:
undetectable		 5zwrB-5oktC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp. 598K) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF16990
(CBM_35)
PF17137
(DUF5110) 		5 PHE A 692
ILE A 677
LEU A 657
ALA A 633
LEU A 617
 None
 1.37A 5zwrB-5x7sA:
undetectable		 5zwrB-5x7sA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y7r IRON/ALPHA-KETOGLUTA
RATE-DEPENDENT
DIOXYGENASE ASQJ

(Aspergillus
nidulans) 		no annotation 5 TYR B  90
ILE B 228
LEU B 100
ALA B 256
LEU B 255
 None
 1.25A 5zwrB-5y7rB:
undetectable		 5zwrB-5y7rB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yc1 TNF
RECEPTOR-ASSOCIATED
FACTOR 4

(Homo sapiens) 		no annotation 5 TYR A 317
ILE A 445
LEU A 390
ALA A 350
LEU A 365
 None
 1.36A 5zwrB-5yc1A:
undetectable		 5zwrB-5yc1A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byi BETA-MANNOSIDASE

(Xanthomonas
citri) 		no annotation 5 TYR A 576
ILE A 647
LEU A 690
ALA A 375
LEU A 669
 None
 1.40A 5zwrB-6byiA:
undetectable		 5zwrB-6byiA:
undetectable