SIMILAR PATTERNS OF AMINO ACIDS FOR 5ZWR_A_9KLA402_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dnp DNA PHOTOLYASE

(Escherichia
coli) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		5 ILE A 133
ARG A 160
LEU A 161
GLY A 137
ALA A 138
 None
 1.18A 5zwrA-1dnpA:
undetectable		 5zwrA-1dnpA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js4 ENDO/EXOCELLULASE E4

(Thermobifida
fusca) 		PF00759
(Glyco_hydro_9)
PF00942
(CBM_3) 		5 TYR A  84
PHE A 324
GLY A  83
ALA A 438
LEU A  10
 None
 1.21A 5zwrA-1js4A:
0.0		 5zwrA-1js4A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kwm PROCARBOXYPEPTIDASE
B

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		5 PHE A  78
ILE A 195
LEU A 271
ALA A 296
LEU A 230
 None
 1.04A 5zwrA-1kwmA:
0.0		 5zwrA-1kwmA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lf9 GLUCOAMYLASE

(Thermoanaerobacterium
thermosaccharolyticum) 		PF00723
(Glyco_hydro_15)
PF09137
(Glucodextran_N) 		5 ILE A 485
LEU A 539
GLY A 454
ALA A 453
LEU A 542
 None
 1.09A 5zwrA-1lf9A:
0.0		 5zwrA-1lf9A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lkf LEUKOCIDIN F SUBUNIT

(Staphylococcus
aureus) 		PF07968
(Leukocidin) 		5 TYR A 149
ILE A 171
TYR A  82
LEU A 192
LEU A  76
 None
 1.21A 5zwrA-1lkfA:
undetectable		 5zwrA-1lkfA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1miu BREAST CANCER TYPE 2
SUSCEPTIBILITY
PROTEIN

(Mus musculus) 		PF09103
(BRCA-2_OB1)
PF09104
(BRCA-2_OB3)
PF09121
(Tower)
PF09169
(BRCA-2_helical) 		5 ILE A2672
LEU A2642
GLY A2676
ALA A2677
LEU A2697
 None
 1.11A 5zwrA-1miuA:
undetectable		 5zwrA-1miuA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nsa PROCARBOXYPEPTIDASE
B

(Sus scrofa) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		5 PHE A  78
ILE A 195
LEU A 271
ALA A 296
LEU A 230
 None
 1.13A 5zwrA-1nsaA:
undetectable		 5zwrA-1nsaA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1otk PHENYLACETIC ACID
DEGRADATION PROTEIN
PAAC

(Escherichia
coli) 		PF05138
(PaaA_PaaC) 		5 ILE A 101
LEU A 170
HIS A 105
ALA A 107
LEU A 192
 None
 0.95A 5zwrA-1otkA:
undetectable		 5zwrA-1otkA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p0n ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE

(Bacillus
subtilis) 		PF01070
(FMN_dh) 		5 PHE A 283
ILE A 302
GLY A  86
ALA A  85
LEU A 296
 None
 1.06A 5zwrA-1p0nA:
undetectable		 5zwrA-1p0nA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rzr GLUCOSE-RESISTANCE
AMYLASE REGULATOR

(Bacillus
megaterium) 		no annotation 5 TYR G 200
ILE G 272
LEU G 172
GLY G 199
LEU G 204
 None
 1.18A 5zwrA-1rzrG:
undetectable		 5zwrA-1rzrG:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s44 CRUSTACYANIN A1
SUBUNIT

(Homarus
gammarus) 		PF00061
(Lipocalin) 		5 TYR A  56
TYR A 112
ILE A 107
LEU A 118
GLY A  33
 None
 1.16A 5zwrA-1s44A:
undetectable		 5zwrA-1s44A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sp3 CYTOCHROME C,
PUTATIVE

(Shewanella
oneidensis) 		PF11783
(Cytochrome_cB)
PF13435
(Cytochrome_C554) 		5 TYR A 387
PHE A 389
ILE A 337
GLY A 256
ALA A 255
 None
 1.04A 5zwrA-1sp3A:
undetectable		 5zwrA-1sp3A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v7v CHITOBIOSE
PHOSPHORYLASE

(Vibrio
proteolyticus) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		5 ILE A 435
TYR A 348
GLY A 381
ALA A 469
LEU A 470
 None
 1.00A 5zwrA-1v7vA:
undetectable		 5zwrA-1v7vA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wac P2 PROTEIN

(Pseudomonas
virus phi6) 		PF00680
(RdRP_1) 		5 PHE A 135
ILE A 340
LEU A 404
GLY A 396
ALA A 397
 None
 1.15A 5zwrA-1wacA:
undetectable		 5zwrA-1wacA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1woc PRIMOSOMAL
REPLICATION PROTEIN
N

(Escherichia
coli) 		PF00436
(SSB) 		5 PHE A  29
ILE A  72
LEU A  31
ALA A  94
LEU A  92
 None
 1.15A 5zwrA-1wocA:
undetectable		 5zwrA-1wocA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yyr TRICHODIENE SYNTHASE

(Fusarium
sporotrichioides) 		PF06330
(TRI5) 		5 PHE A 145
LEU A 148
GLY A 192
ALA A 193
LEU A 150
 None
 1.22A 5zwrA-1yyrA:
undetectable		 5zwrA-1yyrA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zli CARBOXYPEPTIDASE B

(Homo sapiens) 		PF00246
(Peptidase_M14) 		5 PHE A  78
ILE A 195
LEU A 271
ALA A 296
LEU A 230
 None
 1.03A 5zwrA-1zliA:
undetectable		 5zwrA-1zliA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zv9 CELLULOSOMAL
SCAFFOLDIN ADAPTOR
PROTEIN B

(Acetivibrio
cellulolyticus) 		PF00963
(Cohesin) 		5 PHE A 118
ILE A 128
TYR A  58
LEU A  11
GLY A  65
 None
None
None
None
FMT  A4001 (-3.6A)
 1.17A 5zwrA-1zv9A:
undetectable		 5zwrA-1zv9A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ccz PRIMOSOMAL
REPLICATION PROTEIN
N

(Escherichia
coli) 		PF00436
(SSB) 		5 PHE A  29
ILE A  72
LEU A  31
ALA A  94
LEU A  92
 None
 1.15A 5zwrA-2cczA:
undetectable		 5zwrA-2cczA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1p HYPOTHETICAL UPF0163
PROTEIN YHEN
HYPOTHETICAL UPF0116
PROTEIN YHEM

(Escherichia
coli;
Escherichia
coli) 		PF02635
(DrsE)
PF02635
(DrsE) 		5 PHE B   6
LEU B  35
GLY A 113
ALA A 116
LEU A 120
 None
 1.07A 5zwrA-2d1pB:
undetectable		 5zwrA-2d1pB:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dqb DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE,
PUTATIVE

(Thermus
thermophilus) 		PF01966
(HD)
PF13286
(HD_assoc) 		5 ILE A  49
LEU A 158
GLY A 111
ALA A 139
LEU A 140
 None
 1.20A 5zwrA-2dqbA:
undetectable		 5zwrA-2dqbA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e55 URACIL
PHOSPHORIBOSYLTRANSF
ERASE

(Aquifex
aeolicus) 		PF14681
(UPRTase) 		5 ILE A 158
LEU A 195
GLY A  79
ALA A  78
LEU A 202
 None
 1.20A 5zwrA-2e55A:
undetectable		 5zwrA-2e55A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5u VIRION PROTEIN UL25

(Human
alphaherpesvirus
1) 		PF01499
(Herpes_UL25) 		5 TYR A 287
ILE A 382
LEU A 274
GLY A 536
ALA A 539
 None
 1.14A 5zwrA-2f5uA:
undetectable		 5zwrA-2f5uA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hmf PROBABLE
ASPARTOKINASE

(Methanocaldococcus
jannaschii) 		PF00696
(AA_kinase)
PF01842
(ACT)
PF13840
(ACT_7) 		5 TYR A 254
ILE A 298
LEU A 268
GLY A 218
ALA A 215
 None
 1.00A 5zwrA-2hmfA:
undetectable		 5zwrA-2hmfA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nql ISOMERASE/LACTONIZIN
G ENZYME

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A 128
LEU A 373
GLY A 319
ALA A 320
LEU A 354
 None
 1.18A 5zwrA-2nqlA:
undetectable		 5zwrA-2nqlA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6w REPEAT FIVE RESIDUE
(RFR) PROTEIN OR
PENTAPEPTIDE REPEAT
PROTEIN

(Cyanothece) 		PF00805
(Pentapeptide) 		5 ILE A 100
LEU A 102
GLY A 139
ALA A 140
LEU A 142
 None
 1.14A 5zwrA-2o6wA:
undetectable		 5zwrA-2o6wA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ohd PROBABLE MOLYBDENUM
COFACTOR
BIOSYNTHESIS PROTEIN
C

(Sulfurisphaera
tokodaii) 		PF01967
(MoaC) 		5 ILE A  46
LEU A  86
GLY A  53
ALA A 111
LEU A 112
 None
 1.24A 5zwrA-2ohdA:
undetectable		 5zwrA-2ohdA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2py6 METHYLTRANSFERASE
FKBM

(Methylobacillus
flagellatus) 		PF05050
(Methyltransf_21) 		5 TYR A 381
ILE A 357
LEU A 364
GLY A 291
ALA A 349
 None
 1.24A 5zwrA-2py6A:
undetectable		 5zwrA-2py6A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qes RIBOSOME-INACTIVATIN
G PROTEIN PD-L4

(Phytolacca
dioica) 		PF00161
(RIP) 		5 ILE A   4
TYR A  16
ARG A  24
ALA A 177
LEU A 250
 None
 1.24A 5zwrA-2qesA:
undetectable		 5zwrA-2qesA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qmi PBP RELATED
BETA-LACTAMASE

(Pyrococcus
abyssi) 		PF00144
(Beta-lactamase)
PF13969
(Pab87_oct) 		5 TYR A 180
PHE A 199
ILE A 184
LEU A 189
GLY A  58
 None
 1.22A 5zwrA-2qmiA:
34.6		 5zwrA-2qmiA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qp2 UNKNOWN PROTEIN

(Photorhabdus
laumondii) 		PF01823
(MACPF) 		5 PHE A 237
ILE A 241
LEU A 243
GLY A 210
LEU A 101
 None
 1.17A 5zwrA-2qp2A:
undetectable		 5zwrA-2qp2A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvb HALOALKANE
DEHALOGENASE 3

(Mycobacterium
tuberculosis) 		PF00561
(Abhydrolase_1) 		5 ILE A 249
ARG A 255
HIS A 273
GLY A 271
ALA A 244
 None
None
EDO  A   1 (-3.8A)
None
None
 1.11A 5zwrA-2qvbA:
undetectable		 5zwrA-2qvbA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wda PUTATIVE SECRETED
LYASE

(Streptomyces
violaceoruber) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		5 ILE A 720
LEU A 706
GLY A 501
ALA A 502
LEU A 696
 None
 1.16A 5zwrA-2wdaA:
undetectable		 5zwrA-2wdaA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xde GAG POLYPROTEIN

(Human
immunodeficiency
virus 1) 		PF00607
(Gag_p24) 		5 PHE A  40
ILE A 134
LEU A  56
GLY A  46
ALA A  47
 None
None
1B0  A1148 (-4.1A)
None
None
 1.24A 5zwrA-2xdeA:
undetectable		 5zwrA-2xdeA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7d 3-KETO-5-AMINOHEXANO
ATE CLEAVAGE ENZYME

(Candidatus
Cloacimonas
acidaminovorans) 		PF05853
(BKACE) 		5 ILE A 197
LEU A 167
GLY A 110
ALA A 109
LEU A 107
 None
 1.16A 5zwrA-2y7dA:
undetectable		 5zwrA-2y7dA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ce2 PUTATIVE PEPTIDASE

(Chlamydia
abortus) 		PF01432
(Peptidase_M3)
PF08439
(Peptidase_M3_N) 		5 TYR A 326
ILE A 335
LEU A 438
GLY A 390
LEU A 392
 None
 1.19A 5zwrA-3ce2A:
undetectable		 5zwrA-3ce2A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ce6 ADENOSYLHOMOCYSTEINA
SE

(Mycobacterium
tuberculosis) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 LYS A 456
TYR A  53
ILE A 433
GLY A  45
LEU A  77
 None
 1.22A 5zwrA-3ce6A:
undetectable		 5zwrA-3ce6A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cji POLYPROTEIN

(Senecavirus A) 		no annotation 5 TYR A 111
TYR A 241
PHE A 119
LEU A 191
ALA A 114
 None
 1.23A 5zwrA-3cjiA:
undetectable		 5zwrA-3cjiA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1j GLYCOGEN SYNTHASE

(Escherichia
coli) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		5 ILE A  23
LEU A  41
GLY A 141
ALA A 140
LEU A 113
 None
 1.20A 5zwrA-3d1jA:
undetectable		 5zwrA-3d1jA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7l LIN1944 PROTEIN

(Listeria
innocua) 		PF13561
(adh_short_C2) 		5 ILE A  40
LEU A  93
GLY A  34
ALA A  29
LEU A   4
 None
 1.03A 5zwrA-3d7lA:
undetectable		 5zwrA-3d7lA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dsq PYRROLYSYL-TRNA
SYNTHETASE

(Desulfitobacterium
hafniense) 		PF01409
(tRNA-synt_2d) 		5 TYR A 217
ILE A 108
LEU A 240
GLY A 233
ALA A 234
 None
 0.94A 5zwrA-3dsqA:
undetectable		 5zwrA-3dsqA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0x LIPASE-ESTERASE
RELATED PROTEIN

(Clostridium
acetobutylicum) 		PF12146
(Hydrolase_4) 		5 ILE A 242
LEU A  16
GLY A 233
ALA A 235
LEU A  32
 None
 1.12A 5zwrA-3e0xA:
undetectable		 5zwrA-3e0xA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fbg PUTATIVE ARGINATE
LYASE

(Staphylococcus
haemolyticus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 PHE A 220
ILE A 154
LEU A 152
GLY A 127
ALA A 130
 None
 1.02A 5zwrA-3fbgA:
undetectable		 5zwrA-3fbgA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ffu PROBABLE
PYROPHOSPHOHYDROLASE

(Bdellovibrio
bacteriovorus) 		PF00293
(NUDIX) 		5 PHE A  28
ILE A 143
LEU A  86
GLY A  54
ALA A  26
 None
None
None
GTP  A4033 ( 4.0A)
GTP  A4033 ( 4.1A)
 1.22A 5zwrA-3ffuA:
undetectable		 5zwrA-3ffuA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gl1 HEAT SHOCK PROTEIN
SSB1

(Saccharomyces
cerevisiae) 		PF00012
(HSP70) 		5 TYR A 185
ILE A 200
TYR A 220
GLY A 186
ALA A 184
 None
 1.12A 5zwrA-3gl1A:
undetectable		 5zwrA-3gl1A:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5k RIBOSOME-INACTIVATIN
G PROTEIN
PD-L1/PD-L2

(Phytolacca
dioica) 		PF00161
(RIP) 		5 ILE A   4
TYR A  16
ARG A  24
ALA A 177
LEU A 250
 None
 1.22A 5zwrA-3h5kA:
undetectable		 5zwrA-3h5kA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hut PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER

(Rhodospirillum
rubrum) 		PF13458
(Peripla_BP_6) 		5 TYR A 351
LEU A 136
GLY A 330
ALA A 328
LEU A 341
 None
 1.06A 5zwrA-3hutA:
undetectable		 5zwrA-3hutA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hyk HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE

(Bacillus
anthracis) 		PF01648
(ACPS) 		5 ILE A  77
LEU A  89
GLY A  65
ALA A  63
LEU A 114
 None
 1.23A 5zwrA-3hykA:
undetectable		 5zwrA-3hykA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khe CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii) 		PF13499
(EF-hand_7) 		5 ILE A 104
TYR A  66
GLY A   7
ALA A   8
LEU A  42
 None
 1.23A 5zwrA-3kheA:
undetectable		 5zwrA-3kheA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzq PUTATIVE
UNCHARACTERIZED
PROTEIN VP2116

(Vibrio
parahaemolyticus) 		PF13743
(Thioredoxin_5) 		5 ILE A 111
LEU A 131
GLY A  99
ALA A  98
LEU A 137
 None
None
PG6  A 209 (-4.0A)
None
None
 1.02A 5zwrA-3kzqA:
undetectable		 5zwrA-3kzqA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll3 GLUCONATE KINASE

(Lactobacillus
acidophilus) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 ILE A 248
LEU A 446
GLY A 428
ALA A 431
LEU A 435
 None
 1.06A 5zwrA-3ll3A:
undetectable		 5zwrA-3ll3A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m33 UNCHARACTERIZED
PROTEIN

(Deinococcus
radiodurans) 		no annotation 6 PHE A 135
ILE A 122
LEU A 125
GLY A  53
ALA A  52
LEU A  50
 None
 1.10A 5zwrA-3m33A:
undetectable		 5zwrA-3m33A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p09 BETA-LACTAMASE

(Francisella
tularensis) 		PF13354
(Beta-lactamase2) 		5 ILE A 154
LEU A 137
GLY A  69
ALA A  70
LEU A 134
 None
SO4  A 294 (-4.5A)
None
None
None
 1.17A 5zwrA-3p09A:
15.3		 5zwrA-3p09A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uho GLUTAMATE RACEMASE

(Campylobacter
jejuni) 		PF01177
(Asp_Glu_race) 		5 PHE A 167
ILE A 114
LEU A 190
ALA A 162
LEU A 159
 None
 1.19A 5zwrA-3uhoA:
undetectable		 5zwrA-3uhoA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhb R-IMINE REDUCTASE

(Streptomyces
kanamyceticus) 		PF03446
(NAD_binding_2) 		5 TYR A  86
LEU A 191
GLY A 134
ALA A 135
LEU A 137
 None
 0.99A 5zwrA-3zhbA:
undetectable		 5zwrA-3zhbA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zx2 ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE 1

(Rattus
norvegicus) 		PF01150
(GDA1_CD39) 		5 PHE A 440
ILE A 438
LEU A 211
GLY A 417
LEU A 213
 None
None
None
ACY  A 511 (-3.4A)
None
 1.17A 5zwrA-3zx2A:
undetectable		 5zwrA-3zx2A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyt ESTERASE A

(Paenarthrobacter
nitroguajacolicus) 		PF00144
(Beta-lactamase) 		5 LYS A  62
TYR A 148
GLY A 324
ALA A 325
LEU A 229
 None
 1.11A 5zwrA-3zytA:
31.0		 5zwrA-3zytA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ars HISTIDINE ACID
PHOSPHATASE

(Hafnia alvei) 		PF00328
(His_Phos_2) 		5 TYR A 179
PHE A 174
GLY A 212
ALA A 213
LEU A 165
 None
 1.06A 5zwrA-4arsA:
undetectable		 5zwrA-4arsA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1

(Homo sapiens) 		PF00400
(WD40)
PF03451
(HELP) 		5 PHE A 558
ILE A 800
LEU A 549
GLY A 228
LEU A 546
 None
 1.20A 5zwrA-4ci8A:
undetectable		 5zwrA-4ci8A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e5k PHOSPHITE
DEHYDROGENASE
(THERMOSTABLE
VARIANT)

(Pseudomonas
stutzeri) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 PHE A 203
LEU A 205
GLY A 168
ALA A 169
LEU A 171
 None
 0.87A 5zwrA-4e5kA:
undetectable		 5zwrA-4e5kA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		5 PHE A 221
ILE A 237
TYR A 212
GLY A 261
ALA A 245
 None
 1.20A 5zwrA-4euuA:
undetectable		 5zwrA-4euuA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4geu SPINDLE ASSEMBLY
ABNORMAL PROTEIN 6

(Caenorhabditis
elegans) 		PF16531
(SAS-6_N) 		5 PHE A  53
ILE A  38
TYR A  74
LEU A  36
LEU A 148
 None
 1.16A 5zwrA-4geuA:
undetectable		 5zwrA-4geuA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gni PUTATIVE HEAT SHOCK
PROTEIN

(Chaetomium
thermophilum) 		PF00012
(HSP70) 		5 TYR A 194
TYR A 229
ILE A 207
ALA A 193
LEU A 389
 None
 0.93A 5zwrA-4gniA:
undetectable		 5zwrA-4gniA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hsu LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1B

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM)
PF07496
(zf-CW) 		5 TYR A 579
ILE A 582
LEU A 586
GLY A 807
ALA A 808
 None
None
None
None
FAD  A 901 (-3.2A)
 1.18A 5zwrA-4hsuA:
undetectable		 5zwrA-4hsuA:
18.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ivi CARBOXYLESTERASE

(uncultured
bacterium) 		PF00144
(Beta-lactamase) 		6 TYR A  99
LYS A 103
TYR A 172
TYR A 218
GLY A 383
ALA A 384
 None
 0.36A 5zwrA-4iviA:
48.1		 5zwrA-4iviA:
30.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jz6 SALICYLALDEHYDE
DEHYDROGENASE NAHF

(Pseudomonas
putida) 		PF00171
(Aldedh) 		5 PHE A 108
ILE A 159
LEU A 163
ALA A 191
LEU A  67
 None
 1.08A 5zwrA-4jz6A:
undetectable		 5zwrA-4jz6A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lvc S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE)

(Bradyrhizobium
elkanii) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 LYS A 434
TYR A  42
ILE A 409
GLY A  34
LEU A  66
 None
 1.17A 5zwrA-4lvcA:
undetectable		 5zwrA-4lvcA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mbg CAAX
FARNESYLTRANSFERASE
ALPHA SUBUNIT RAM2
CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus;
Aspergillus
fumigatus) 		PF01239
(PPTA)
PF00432
(Prenyltrans) 		5 TYR A  39
ILE A  66
ARG A  47
LEU A  46
GLY B 193
 None
None
EDO  A 401 ( 2.9A)
EDO  A 402 (-4.5A)
None
 1.13A 5zwrA-4mbgA:
undetectable		 5zwrA-4mbgA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mbg CAAX
FARNESYLTRANSFERASE
ALPHA SUBUNIT RAM2
CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus;
Aspergillus
fumigatus) 		PF01239
(PPTA)
PF00432
(Prenyltrans) 		5 TYR A  39
ILE A  66
TYR A  35
ARG A  47
GLY B 193
 None
None
EDO  A 401 (-3.8A)
EDO  A 401 ( 2.9A)
None
 0.93A 5zwrA-4mbgA:
undetectable		 5zwrA-4mbgA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata) 		PF01580
(FtsK_SpoIIIE) 		5 ILE A1244
LEU A1113
GLY A1250
ALA A1251
LEU A1282
 None
 1.22A 5zwrA-4nh0A:
undetectable		 5zwrA-4nh0A:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE

(Geobacter
sulfurreducens) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		6 TYR A 974
PHE A 978
ILE A 757
TYR A 617
LEU A 726
ALA A 665
 None
 1.38A 5zwrA-4nmeA:
undetectable		 5zwrA-4nmeA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nnb OBCA, OXALATE
BIOSYNTHETIC
COMPONENT A

(Burkholderia
glumae) 		PF05853
(BKACE) 		5 ILE A 425
LEU A 463
GLY A 378
ALA A 377
LEU A 375
 None
 1.13A 5zwrA-4nnbA:
undetectable		 5zwrA-4nnbA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4okm TERPENE SYNTHASE
METAL-BINDING
DOMAIN-CONTAINING
PROTEIN

(Streptomyces
pristinaespiralis) 		no annotation 5 PHE A  55
ILE A  59
LEU A  71
GLY A 182
LEU A  78
 None
None
None
PPV  A 904 ( 3.8A)
None
 1.01A 5zwrA-4okmA:
undetectable		 5zwrA-4okmA:
23.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6b EST-Y29

(metagenome) 		PF00144
(Beta-lactamase) 		10 TYR A  57
LYS A  61
TYR A 123
PHE A 125
ILE A 141
TYR A 170
HIS A 261
GLY A 347
ALA A 348
LEU A 370
 None
 0.33A 5zwrA-4p6bA:
71.3		 5zwrA-4p6bA:
99.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psn SSDNA BINDING
PROTEIN

(Aeropyrum
pernix) 		PF10015
(DUF2258) 		5 TYR A  14
ILE A  69
GLY A  45
ALA A  44
LEU A  22
 None
 1.03A 5zwrA-4psnA:
undetectable		 5zwrA-4psnA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qax 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Staphylococcus
aureus) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		5 ILE A 390
LEU A 388
GLY A  72
ALA A 482
LEU A 486
 None
 1.10A 5zwrA-4qaxA:
undetectable		 5zwrA-4qaxA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 PHE A3046
ILE A2993
GLY A3008
ALA A3007
LEU A3003
 None
 1.17A 5zwrA-4qyrA:
undetectable		 5zwrA-4qyrA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ra7 PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE

(Atopobium
parvulum) 		PF00905
(Transpeptidase) 		5 PHE A 761
ILE A 817
GLY A 692
ALA A 691
LEU A 754
 None
 1.11A 5zwrA-4ra7A:
13.7		 5zwrA-4ra7A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rdj CAPSID

(Norwalk virus) 		PF00915
(Calici_coat)
PF08435
(Calici_coat_C) 		5 TYR A 409
TYR A 314
GLY A 410
ALA A 416
LEU A 419
 None
 1.23A 5zwrA-4rdjA:
undetectable		 5zwrA-4rdjA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxl MOLYBDENUM ABC
TRANSPORTER,
PERIPLASMIC
MOLYBDENUM-BINDING
PROTEIN

(Vibrio cholerae) 		PF13531
(SBP_bac_11) 		5 ILE A 109
TYR A 191
GLY A 147
ALA A 150
LEU A 154
 None
WO4  A 301 (-4.5A)
None
None
None
 1.08A 5zwrA-4rxlA:
undetectable		 5zwrA-4rxlA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4woq N-ACETYLNEURAMINATE
LYASE

(Clostridioides
difficile) 		PF00701
(DHDPS) 		5 ILE A 129
LEU A 165
GLY A  92
ALA A 116
LEU A 144
 None
 0.97A 5zwrA-4woqA:
undetectable		 5zwrA-4woqA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xa9 GALA PROTEIN TYPE 1,
3 OR 4

(Legionella
pneumophila) 		PF13516
(LRR_6) 		5 ILE A 163
LEU A 166
GLY A 130
ALA A 131
LEU A 149
 None
 1.19A 5zwrA-4xa9A:
undetectable		 5zwrA-4xa9A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dnw SHKAI2IB

(Striga
hermonthica) 		PF12697
(Abhydrolase_6) 		5 TYR A 201
ILE A 106
GLY A  72
ALA A  74
LEU A  77
 None
 1.20A 5zwrA-5dnwA:
undetectable		 5zwrA-5dnwA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fac ALANINE RACEMASE

(Streptomyces
coelicolor) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 ILE A 251
TYR A 374
GLY A 239
ALA A 241
LEU A 259
 None
PLP  A 401 (-4.2A)
PLP  A 401 (-3.4A)
None
None
 1.23A 5zwrA-5facA:
undetectable		 5zwrA-5facA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikz OXALATE BIOSYNTHETIC
COMPONENT 1

(Burkholderia
thailandensis) 		PF05853
(BKACE) 		5 ILE A 835
LEU A 833
GLY A 800
ALA A 802
LEU A 751
 None
 1.17A 5zwrA-5ikzA:
undetectable		 5zwrA-5ikzA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1q CARBOXYPEPTIDASE B

(Sus scrofa) 		PF00246
(Peptidase_M14) 		5 PHE A  78
ILE A 195
LEU A 271
ALA A 296
LEU A 230
 None
 1.12A 5zwrA-5j1qA:
undetectable		 5zwrA-5j1qA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbw 3-HYDROXYBUTYRYL-COA
DEHYDRATASE

(Myxococcus
xanthus) 		PF00378
(ECH_1) 		5 ILE A 137
ARG A  69
GLY A  63
ALA A  64
LEU A  66
 None
 1.14A 5zwrA-5jbwA:
undetectable		 5zwrA-5jbwA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jhq TANKYRASE-1

(Homo sapiens) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13606
(Ank_3) 		5 LYS A 210
ILE A 251
HIS A 221
ALA A 240
LEU A 236
 None
 1.08A 5zwrA-5jhqA:
undetectable		 5zwrA-5jhqA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mb9 PUTATIVE HEAT SHOCK
PROTEIN

(Chaetomium
thermophilum) 		PF00012
(HSP70) 		5 TYR A 194
TYR A 229
ILE A 207
ALA A 193
LEU A 389
 None
 1.05A 5zwrA-5mb9A:
undetectable		 5zwrA-5mb9A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqx NON-STRUCTURAL
PROTEIN3

(Venezuelan
equine
encephalitis
virus) 		no annotation 5 ILE A 106
LEU A 128
GLY A  53
ALA A  88
LEU A  85
 None
 1.19A 5zwrA-5mqxA:
undetectable		 5zwrA-5mqxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t6o POLY-BETA-HYDROXYBUT
ERATE POLYMERASE

(Cupriavidus
necator) 		PF07167
(PhaC_N) 		5 TYR A 437
ILE A 247
TYR A 292
GLY A 434
LEU A 441
 None
 1.19A 5zwrA-5t6oA:
undetectable		 5zwrA-5t6oA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u9e HTH-TYPE
TRANSCRIPTIONAL
ACTIVATOR RHAR

(Bacteria
Latreille et
al. 1825) 		no annotation 5 TYR A  67
PHE A 152
ILE A  87
LEU A 155
GLY A 106
 None
 1.16A 5zwrA-5u9eA:
undetectable		 5zwrA-5u9eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uc0 UNCHARACTERIZED
PROTEIN COG5400

(Brucella
abortus) 		PF06577
(DUF1134) 		5 TYR A 141
ILE A 137
LEU A 134
HIS A 107
GLY A  97
 None
 1.06A 5zwrA-5uc0A:
undetectable		 5zwrA-5uc0A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xb7 BETA-GALACTOSIDASE

(Bifidobacterium
animalis) 		no annotation 5 TYR A 344
TYR A 280
GLY A 360
ALA A 314
LEU A 327
 None
 1.00A 5zwrA-5xb7A:
undetectable		 5zwrA-5xb7A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgc RAP1 GTPASE-GDP
DISSOCIATION
STIMULATOR 1

(Homo sapiens) 		PF00514
(Arm) 		5 ILE A 425
LEU A 446
GLY A 474
ALA A 476
LEU A 480
 None
 1.07A 5zwrA-5xgcA:
undetectable		 5zwrA-5xgcA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvu CASEIN KINASE 2,
ALPHA SUBUNIT

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		5 ILE A 249
TYR A 201
LEU A 253
GLY A 228
ALA A 227
 None
 1.10A 5zwrA-5xvuA:
undetectable		 5zwrA-5xvuA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y31 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 22

(Homo sapiens) 		no annotation 5 ILE A 345
LEU A 642
GLY A 341
ALA A 342
LEU A 306
 None
 1.22A 5zwrA-5y31A:
undetectable		 5zwrA-5y31A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y7r IRON/ALPHA-KETOGLUTA
RATE-DEPENDENT
DIOXYGENASE ASQJ

(Aspergillus
nidulans) 		no annotation 5 TYR B 114
PHE B 158
ILE B 103
GLY B 231
LEU B 259
 None
 1.19A 5zwrA-5y7rB:
undetectable		 5zwrA-5y7rB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvt C-TERMINUS OF OUTER
CAPSID PROTEIN VP5

(Aquareovirus C) 		no annotation 5 TYR B 322
LEU B 459
GLY B 401
ALA B 400
LEU B 420
 None
 1.21A 5zwrA-5zvtB:
undetectable		 5zwrA-5zvtB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7paz PSEUDOAZURIN

(Alcaligenes
faecalis) 		PF00127
(Copper-bind) 		5 TYR A  22
ILE A 119
LEU A 115
GLY A  72
ALA A  73
 None
 1.10A 5zwrA-7pazA:
undetectable		 5zwrA-7pazA:
14.57