SIMILAR PATTERNS OF AMINO ACIDS FOR 5ZW4_A_SAMA302_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b1b PROTEIN (IRON
DEPENDENT REGULATOR)

(Mycobacterium
tuberculosis) 		PF01325
(Fe_dep_repress)
PF02742
(Fe_dep_repr_C) 		4 GLU A  83
ARG A  84
ARG A  80
ASP A  88
 ZN  A 301 (-2.6A)
None
SO4  A 303 (-4.0A)
None
 1.21A 5zw4A-1b1bA:
undetectable		 5zw4A-1b1bA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eg1 ENDOGLUCANASE I

(Trichoderma
reesei) 		PF00840
(Glyco_hydro_7) 		4 SER A 148
GLU A 201
ASP A 322
ASP A 172
 None
 1.23A 5zw4A-1eg1A:
undetectable		 5zw4A-1eg1A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fob BETA-1,4-GALACTANASE

(Aspergillus
aculeatus) 		PF07745
(Glyco_hydro_53) 		4 SER A  83
ARG A 138
ASP A 182
ASP A  91
 None
 1.12A 5zw4A-1fobA:
undetectable		 5zw4A-1fobA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq8 PECTINESTERASE

(Daucus carota) 		PF01095
(Pectinesterase) 		4 SER A 121
ARG A  99
ARG A  36
ASP A 100
 None
 1.06A 5zw4A-1gq8A:
undetectable		 5zw4A-1gq8A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lvg GUANYLATE KINASE

(Mus musculus) 		PF00625
(Guanylate_kin) 		4 GLU A  47
ARG A  44
ASP A  49
ASP A 101
 None
5GP  A1202 (-3.1A)
None
5GP  A1202 ( 3.4A)
 1.17A 5zw4A-1lvgA:
undetectable		 5zw4A-1lvgA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ph5 TELOMERE-BINDING
PROTEIN ALPHA
SUBUNIT

(Sterkiella nova) 		PF02765
(POT1) 		4 SER A  95
ARG A 272
ASP A 247
ASP A 209
 None
 1.21A 5zw4A-1ph5A:
undetectable		 5zw4A-1ph5A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q2l PROTEASE III

(Escherichia
coli) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF16187
(Peptidase_M16_M) 		4 GLU A 769
ARG A 810
ASP A 888
ASP A 881
 None
 1.28A 5zw4A-1q2lA:
undetectable		 5zw4A-1q2lA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6z CHIMERA OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND ARGONAUTE 2

(Escherichia
coli;
Drosophila
melanogaster) 		no annotation 4 SER P 702
GLU P 631
ARG P 628
ARG P 627
 None
 1.06A 5zw4A-1r6zP:
undetectable		 5zw4A-1r6zP:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ryy ALPHA-AMINO ACID
ESTER HYDROLASE

(Acetobacter
pasteurianus) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		4 GLU A 177
ARG A 164
ASP A 149
ASP A 183
 None
 1.21A 5zw4A-1ryyA:
undetectable		 5zw4A-1ryyA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wrb DJVLGB

(Dugesia
japonica) 		PF00270
(DEAD) 		4 SER A 232
GLU A 343
ARG A 346
ASP A 349
 SO4  A1001 (-3.6A)
None
None
None
 1.14A 5zw4A-1wrbA:
4.1		 5zw4A-1wrbA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yb2 HYPOTHETICAL PROTEIN
TA0852

(Thermoplasma
acidophilum) 		PF08704
(GCD14) 		4 SER A 105
GLU A 122
ARG A 123
ASP A 150
 None
 0.78A 5zw4A-1yb2A:
14.3		 5zw4A-1yb2A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yxy PUTATIVE
N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE

(Streptococcus
pyogenes) 		PF04131
(NanE) 		4 ARG A 114
ARG A 112
ASP A 116
ASP A  79
 None
 1.02A 5zw4A-1yxyA:
undetectable		 5zw4A-1yxyA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bcc UBIQUINOL CYTOCHROME
C OXIDOREDUCTASE

(Gallus gallus) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 ARG A 244
ARG A 242
ASP A 246
ASP A 332
 None
 1.26A 5zw4A-2bccA:
undetectable		 5zw4A-2bccA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bkd FRAGILE X MENTAL
RETARDATION 1
PROTEIN

(Homo sapiens) 		PF05641
(Agenet) 		4 SER N  69
GLU N   7
ARG N   9
ASP N  46
 None
None
HSO  N  45 ( 3.9A)
HSO  N  45 ( 3.7A)
 1.30A 5zw4A-2bkdN:
undetectable		 5zw4A-2bkdN:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2br4 CEPHALOSPORIN
HYDROXYLASE CMCI

(Streptomyces
clavuligerus) 		PF04989
(CmcI) 		4 SER A  95
ARG A 117
ASP A 138
ASP A 160
 SAM  A 301 (-3.0A)
SAM  A 301 (-3.7A)
SAM  A 301 (-3.7A)
MG  A 300 ( 3.6A)
 1.12A 5zw4A-2br4A:
14.4		 5zw4A-2br4A:
23.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gpy O-METHYLTRANSFERASE

(Bacillus
halodurans) 		PF01596
(Methyltransf_3) 		4 GLU A  85
ARG A  90
ASP A 113
ASP A 133
 None
None
ZN  A 306 ( 4.7A)
None
 0.75A 5zw4A-2gpyA:
26.8		 5zw4A-2gpyA:
49.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gpy O-METHYLTRANSFERASE

(Bacillus
halodurans) 		PF01596
(Methyltransf_3) 		4 SER A  68
GLU A  85
ARG A  90
ASP A 113
 None
None
None
ZN  A 306 ( 4.7A)
 0.79A 5zw4A-2gpyA:
26.8		 5zw4A-2gpyA:
49.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7n RNA-DEPENDENT RNA
POLYMERASE

(Neurospora
crassa) 		PF05183
(RdRP) 		4 GLU A 872
ARG A 901
ASP A 897
ASP A 869
 None
 1.01A 5zw4A-2j7nA:
undetectable		 5zw4A-2j7nA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ml2 POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 6

(Azotobacter
vinelandii) 		no annotation 4 SER A 114
GLU A 137
ARG A  51
ARG A  73
 None
 1.31A 5zw4A-2ml2A:
undetectable		 5zw4A-2ml2A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oi6 BIFUNCTIONAL PROTEIN
GLMU

(Escherichia
coli) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		4 SER A 301
ARG A 331
ASP A 369
ASP A 317
 None
 1.07A 5zw4A-2oi6A:
undetectable		 5zw4A-2oi6A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oo3 PROTEIN INVOLVED IN
CATABOLISM OF
EXTERNAL DNA

(Legionella
pneumophila) 		PF04378
(RsmJ) 		4 SER A 101
GLU A 119
ASP A 144
ASP A 165
 None
 0.74A 5zw4A-2oo3A:
11.4		 5zw4A-2oo3A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ool SENSOR PROTEIN

(Rhodopseudomonas
palustris) 		PF01590
(GAF)
PF08446
(PAS_2) 		4 SER A 139
ARG A 174
ARG A 304
ASP A 199
 None
 1.30A 5zw4A-2oolA:
undetectable		 5zw4A-2oolA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2psb YERB PROTEIN

(Bacillus
subtilis) 		PF11258
(DUF3048)
PF17479
(DUF3048_C) 		4 SER A 115
GLU A  87
ARG A 246
ASP A 242
 None
 1.10A 5zw4A-2psbA:
undetectable		 5zw4A-2psbA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v4j SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA
SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA

(Desulfovibrio
vulgaris;
Desulfovibrio
vulgaris) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 SER A 235
ARG B 183
ARG A 231
ASP A 219
 None
SH0  A 503 (-3.8A)
SRM  B 503 (-4.1A)
SF4  A 501 ( 4.8A)
 1.11A 5zw4A-2v4jA:
undetectable		 5zw4A-2v4jA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vl7 XPD

(Sulfurisphaera
tokodaii) 		PF06733
(DEAD_2)
PF13307
(Helicase_C_2) 		4 GLU A 524
ARG A 521
ASP A 528
ASP A 487
 None
 1.23A 5zw4A-2vl7A:
2.2		 5zw4A-2vl7A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x05 EXO-BETA-D-GLUCOSAMI
NIDASE

(Amycolatopsis
orientalis) 		PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N) 		4 SER A  86
ARG A 168
ARG A 217
ASP A 170
 None
 1.20A 5zw4A-2x05A:
undetectable		 5zw4A-2x05A:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x2u PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF00028
(Cadherin) 		4 GLU A 178
ARG A 177
ARG A 231
ASP A  58
 None
 1.18A 5zw4A-2x2uA:
undetectable		 5zw4A-2x2uA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xt4 MCBG-LIKE PROTEIN

(Xanthomonas
albilineans) 		PF00805
(Pentapeptide)
PF13599
(Pentapeptide_4) 		4 GLU A  32
ARG A  30
ARG A  52
ASP A  10
 None
 1.26A 5zw4A-2xt4A:
undetectable		 5zw4A-2xt4A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zr2 SERYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00587
(tRNA-synt_2b)
PF02403
(Seryl_tRNA_N) 		4 SER A 411
GLU A 285
ARG A 298
ASP A 234
 AMP  A1001 (-3.1A)
AMP  A1001 (-3.6A)
SO4  A2003 (-3.0A)
None
 0.82A 5zw4A-2zr2A:
undetectable		 5zw4A-2zr2A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026

(Methanocaldococcus
jannaschii) 		PF01189
(Methyltr_RsmB-F) 		4 GLU A 115
ARG A 120
ASP A 142
ASP A 163
 SFG  A 500 (-2.6A)
SFG  A 500 (-4.4A)
SFG  A 500 (-4.0A)
SFG  A 500 (-3.7A)
 0.86A 5zw4A-3a4tA:
15.2		 5zw4A-3a4tA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bpk NITRILOTRIACETATE
MONOOXYGENASE
COMPONENT B

(Bacillus cereus) 		PF01613
(Flavin_Reduct) 		4 GLU A  67
ARG A  68
ASP A 153
ASP A 148
 None
 1.19A 5zw4A-3bpkA:
undetectable		 5zw4A-3bpkA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bzm MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE

(Escherichia
coli) 		PF00425
(Chorismate_bind) 		4 SER A 238
GLU A 253
ARG A 251
ARG A 320
 None
None
CIT  A 432 (-3.6A)
None
 1.22A 5zw4A-3bzmA:
undetectable		 5zw4A-3bzmA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dxq CHOLINE/ETHANOLAMINE
KINASE FAMILY
PROTEIN

(Mesorhizobium
loti) 		PF01633
(Choline_kinase) 		4 GLU A  57
ARG A  42
ARG A  54
ASP A 178
 None
 1.07A 5zw4A-3dxqA:
undetectable		 5zw4A-3dxqA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3flb RIFR

(Amycolatopsis
mediterranei) 		PF00975
(Thioesterase) 		4 GLU A  48
ARG A  15
ARG A  22
ASP A  18
 None
 1.27A 5zw4A-3flbA:
undetectable		 5zw4A-3flbA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6e MUCONATE
CYCLOISOMERASE I

(Ruegeria
pomeroyi) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLU A  51
ARG A 120
ASP A 116
ASP A 364
 None
 1.25A 5zw4A-3i6eA:
undetectable		 5zw4A-3i6eA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kya PUTATIVE PHOSPHATASE

(Bacteroides
thetaiotaomicron) 		PF01833
(TIG) 		4 ARG A 464
ARG A 440
ASP A 455
ASP A 467
 None
 0.85A 5zw4A-3kyaA:
undetectable		 5zw4A-3kyaA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll7 PUTATIVE
METHYLTRANSFERASE

(Porphyromonas
gingivalis) 		no annotation 4 GLU A 119
ARG A 120
ASP A 148
ASP A 167
 None
None
None
EDO  A 507 (-4.1A)
 1.00A 5zw4A-3ll7A:
12.6		 5zw4A-3ll7A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mc2 INHIBITOR OF
CARBONIC ANHYDRASE

(Mus musculus) 		PF00405
(Transferrin) 		4 SER A 592
ARG A 346
ASP A 350
ASP A 381
 None
 1.23A 5zw4A-3mc2A:
undetectable		 5zw4A-3mc2A:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mqz UNCHARACTERIZED
CONSERVED PROTEIN
DUF1054

(Leptospirillum
rubarum) 		PF06335
(DUF1054) 		4 ARG A 108
ARG A 184
ASP A 180
ASP A 152
 None
 1.17A 5zw4A-3mqzA:
undetectable		 5zw4A-3mqzA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myr HYDROGENASE (NIFE)
SMALL SUBUNIT HYDA
NICKEL-DEPENDENT
HYDROGENASE LARGE
SUBUNIT

(Allochromatium
vinosum;
Allochromatium
vinosum) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C)
PF00374
(NiFeSe_Hases) 		4 SER A 204
GLU A 208
ASP B1229
ASP A 206
 None
 1.01A 5zw4A-3myrA:
undetectable		 5zw4A-3myrA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6r PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT

(Roseobacter
denitrificans) 		PF01039
(Carboxyl_trans) 		4 GLU B  68
ARG B  69
ASP B 264
ASP B  56
 None
 1.26A 5zw4A-3n6rB:
undetectable		 5zw4A-3n6rB:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyq MALONYL-COA LIGASE

(Streptomyces
coelicolor) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 SER A 259
ARG A 302
ARG A 279
ASP A 375
 None
 1.22A 5zw4A-3nyqA:
undetectable		 5zw4A-3nyqA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sgg HYPOTHETICAL
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF14323
(GxGYxYP_C)
PF16216
(GxGYxYP_N) 		4 SER A 390
ARG A 462
ASP A 460
ASP A 428
 None
 0.98A 5zw4A-3sggA:
undetectable		 5zw4A-3sggA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t95 AUTOINDUCER
2-BINDING PROTEIN
LSRB

(Yersinia pestis) 		PF13407
(Peripla_BP_4) 		4 GLU A 121
ARG A 123
ASP A 117
ASP A 312
 None
 1.31A 5zw4A-3t95A:
2.9		 5zw4A-3t95A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tgl TRIACYL-GLYCEROL
ACYLHYDROLASE

(Rhizomucor
miehei) 		PF01764
(Lipase_3) 		4 GLU A 162
ARG A 160
ASP A 156
ASP A 128
 None
 1.07A 5zw4A-3tglA:
undetectable		 5zw4A-3tglA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1

(Bos taurus) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF08282
(Hydrolase_3)
PF13246
(Cation_ATPase) 		4 SER A 424
ARG A 131
ARG A 134
ASP A 149
 None
 0.86A 5zw4A-3tlmA:
undetectable		 5zw4A-3tlmA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tv2 FUMARATE HYDRATASE,
CLASS II

(Burkholderia
pseudomallei) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		4 SER A 545
GLU A 448
ASP A 434
ASP A 331
 None
 1.29A 5zw4A-3tv2A:
undetectable		 5zw4A-3tv2A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3twd BIFUNCTIONAL PROTEIN
GLMU

(Escherichia
coli) 		PF00132
(Hexapep) 		4 SER A 301
ARG A 331
ASP A 369
ASP A 317
 None
 1.07A 5zw4A-3twdA:
undetectable		 5zw4A-3twdA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v7n THREONINE SYNTHASE

(Burkholderia
thailandensis) 		PF00291
(PALP)
PF14821
(Thr_synth_N) 		4 ARG A  78
ARG A  79
ASP A  55
ASP A  72
 None
 1.27A 5zw4A-3v7nA:
2.3		 5zw4A-3v7nA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING

(Desulfovibrio
vulgaris) 		PF00374
(NiFeSe_Hases) 		4 GLU B 462
ARG B  46
ARG B 458
ASP B 453
 None
 1.06A 5zw4A-3ze7B:
undetectable		 5zw4A-3ze7B:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING

(Desulfovibrio
vulgaris) 		PF00374
(NiFeSe_Hases) 		4 SER B 325
GLU B 462
ARG B  46
ASP B 453
 None
 1.26A 5zw4A-3ze7B:
undetectable		 5zw4A-3ze7B:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5p PROTEIN MXIA

(Shigella
flexneri) 		PF00771
(FHIPEP) 		4 SER A 553
GLU A 569
ARG A 572
ASP A 650
 None
 1.21A 5zw4A-4a5pA:
undetectable		 5zw4A-4a5pA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b9y ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B

(Cellvibrio
japonicus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF17137
(DUF5110) 		4 SER A 716
GLU A 708
ASP A 687
ASP A 710
 None
 1.20A 5zw4A-4b9yA:
2.1		 5zw4A-4b9yA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4blu RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J

(Escherichia
coli) 		PF04378
(RsmJ) 		4 SER A 100
GLU A 118
ASP A 143
ASP A 164
 None
None
None
TRS  A1281 ( 3.0A)
 0.90A 5zw4A-4bluA:
10.7		 5zw4A-4bluA:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bs9 TRUD

(uncultured
Prochloron sp.
06037A) 		PF02624
(YcaO) 		4 GLU A 333
ARG A 330
ARG A 329
ASP A 726
 None
 1.21A 5zw4A-4bs9A:
undetectable		 5zw4A-4bs9A:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cwe REPLICATION
INITIATION PROTEIN,
REPLICATION
INITIATION PROTEIN

(Staphylococcus
aureus) 		PF02486
(Rep_trans) 		4 GLU A 216
ARG A 182
ARG A 189
ASP A 183
 None
 1.30A 5zw4A-4cweA:
undetectable		 5zw4A-4cweA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f1n KPAGO

(Vanderwaltozyma
polyspora) 		PF02171
(Piwi) 		4 GLU A 511
ARG A 504
ASP A 502
ASP A 517
 None
 1.13A 5zw4A-4f1nA:
undetectable		 5zw4A-4f1nA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hgv FUMARATE HYDRATASE
CLASS II

(Sinorhizobium
meliloti) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		4 SER A 415
GLU A 318
ASP A 304
ASP A 201
 None
 1.26A 5zw4A-4hgvA:
undetectable		 5zw4A-4hgvA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hgx XYLOSE ISOMERASE
DOMAIN CONTAINING
PROTEIN

(Salmonella
enterica) 		PF01261
(AP_endonuc_2) 		4 SER A 199
GLU A  37
ARG A  39
ASP A 170
 None
None
None
ZN  A 301 (-3.0A)
 1.31A 5zw4A-4hgxA:
undetectable		 5zw4A-4hgxA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE

(Saccharomyces
cerevisiae) 		PF03200
(Glyco_hydro_63)
PF16923
(Glyco_hydro_63N) 		4 SER A  46
ARG A 209
ARG A  54
ASP A  48
 None
 1.18A 5zw4A-4j5tA:
undetectable		 5zw4A-4j5tA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE

(Saccharomyces
cerevisiae) 		PF03200
(Glyco_hydro_63)
PF16923
(Glyco_hydro_63N) 		4 SER A  46
ARG A 209
ARG A  54
ASP A 210
 None
 1.27A 5zw4A-4j5tA:
undetectable		 5zw4A-4j5tA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mdv ANNEXIN

(Schistosoma
mansoni) 		PF00191
(Annexin) 		4 GLU A 269
ARG A 285
ARG A 277
ASP A 289
 None
 1.27A 5zw4A-4mdvA:
undetectable		 5zw4A-4mdvA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mtk VGRG1

(Pseudomonas
aeruginosa) 		PF05954
(Phage_GPD) 		4 GLU A 341
ARG A 289
ARG A 323
ASP A 212
 SO4  A 745 ( 4.9A)
SO4  A 721 (-3.2A)
SO4  A 745 (-4.4A)
None
 0.75A 5zw4A-4mtkA:
undetectable		 5zw4A-4mtkA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pbv NT-3 GROWTH FACTOR
RECEPTOR
PROTEIN-TYROSINE
PHOSPHATASE
CRYPALPHA1 ISOFORM

(Gallus gallus;
Gallus gallus) 		PF00047
(ig)
PF13855
(LRR_8)
PF16920
(TPKR_C2)
PF07679
(I-set)
PF13927
(Ig_3) 		4 SER A 143
ARG C  76
ARG A 121
ASP A 242
 None
 1.31A 5zw4A-4pbvA:
undetectable		 5zw4A-4pbvA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rv0 TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
TER94

(Drosophila
melanogaster) 		PF02359
(CDC48_N)
PF02933
(CDC48_2) 		4 ARG A  80
ARG A  86
ASP A  71
ASP A  31
 None
SO4  A 201 (-3.5A)
None
None
 1.15A 5zw4A-4rv0A:
undetectable		 5zw4A-4rv0A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4sli INTRAMOLECULAR
TRANS-SIALIDASE

(Macrobdella
decora) 		PF02973
(Sialidase)
PF13088
(BNR_2) 		4 SER A 666
GLU A 729
ARG A 312
ASP A 310
 None
None
CNP  A 760 (-3.6A)
None
 1.24A 5zw4A-4sliA:
undetectable		 5zw4A-4sliA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro) 		4 SER A  67
GLU A 184
ARG A 187
ASP A 161
 None
 1.25A 5zw4A-4wzbA:
3.0		 5zw4A-4wzbA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a05 ALDOSE-ALDOSE
OXIDOREDUCTASE

(Caulobacter
vibrioides) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 GLU A 260
ARG A 249
ARG A 273
ASP A 160
 None
 1.14A 5zw4A-5a05A:
5.7		 5zw4A-5a05A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0z CHOLINE
TRIMETHYLAMINE LYASE

(Klebsiella
pneumoniae) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 SER A 663
ARG A 355
ARG A 412
ASP A 438
 None
 1.30A 5zw4A-5a0zA:
undetectable		 5zw4A-5a0zA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ccx TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRMT61A

(Homo sapiens) 		PF08704
(GCD14) 		4 GLU A 135
ARG A 140
ASP A 163
ASP A 181
 SAH  A 301 (-2.2A)
SAH  A 301 (-3.9A)
SAH  A 301 (-2.7A)
SAH  A 301 (-2.4A)
 0.72A 5zw4A-5ccxA:
18.3		 5zw4A-5ccxA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ccx TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRMT61A

(Homo sapiens) 		PF08704
(GCD14) 		4 SER A 118
GLU A 135
ARG A 140
ASP A 163
 None
SAH  A 301 (-2.2A)
SAH  A 301 (-3.9A)
SAH  A 301 (-2.7A)
 1.26A 5zw4A-5ccxA:
18.3		 5zw4A-5ccxA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6b FUMARATE HYDRATASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		4 SER A 452
GLU A 355
ASP A 341
ASP A 238
 None
 1.28A 5zw4A-5d6bA:
undetectable		 5zw4A-5d6bA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d95 AMINOTRANSFERASE
CLASS-III

(Sphaerobacter
thermophilus) 		PF00202
(Aminotran_3) 		4 SER A 372
GLU A 339
ARG A 342
ASP A  82
 None
 1.25A 5zw4A-5d95A:
undetectable		 5zw4A-5d95A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dlb CHAPERONE ESPG3

(Mycobacterium
marinum) 		PF14011
(ESX-1_EspG) 		4 SER A 257
GLU A 215
ARG A  87
ASP A  85
 SCN  A 314 ( 2.9A)
None
None
None
 1.24A 5zw4A-5dlbA:
undetectable		 5zw4A-5dlbA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae) 		PF08704
(GCD14) 		4 GLU B 139
ARG B 144
ASP B 168
ASP B 203
 SAM  B 401 (-2.9A)
SAM  B 401 (-4.7A)
SAM  B 401 (-3.5A)
SAM  B 401 (-3.3A)
 0.53A 5zw4A-5ergB:
17.0		 5zw4A-5ergB:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae) 		PF08704
(GCD14) 		4 SER B 125
GLU B 139
ARG B 144
ASP B 168
 None
SAM  B 401 (-2.9A)
SAM  B 401 (-4.7A)
SAM  B 401 (-3.5A)
 1.09A 5zw4A-5ergB:
17.0		 5zw4A-5ergB:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f9s SERINE--PYRUVATE
AMINOTRANSFERASE

(Homo sapiens) 		PF00266
(Aminotran_5) 		4 SER A 218
GLU A  87
ARG A 118
ASP A 114
 None
 1.26A 5zw4A-5f9sA:
undetectable		 5zw4A-5f9sA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6
LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6

(Homo sapiens;
Homo sapiens) 		PF00058
(Ldl_recept_b)
PF14670
(FXa_inhibition)
PF00058
(Ldl_recept_b)
PF14670
(FXa_inhibition) 		4 GLU A 448
ARG B 853
ASP B 874
ASP A 425
 None
 1.29A 5zw4A-5gjeA:
undetectable		 5zw4A-5gjeA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz1 MESO-DIAMINOPIMELATE
D-DEHYDROGENASE

(Ureibacillus
thermosphaericus) 		PF01113
(DapB_N)
PF16654
(DAPDH_C) 		4 SER A  46
GLU A  29
ARG A   5
ASP A  64
 None
 1.22A 5zw4A-5gz1A:
undetectable		 5zw4A-5gz1A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5knm CDNA FLJ39643 FIS,
CLONE SMINT2004023,
HIGHLY SIMILAR TO
HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, ALPHACHAIN
F
BETA-2-MICROGLOBULIN

(Homo sapiens;
Homo sapiens) 		PF00129
(MHC_I)
PF07654
(C1-set)
PF07654
(C1-set) 		4 GLU A  49
ARG A  48
ASP B  53
ASP A 238
 None
 1.24A 5zw4A-5knmA:
undetectable		 5zw4A-5knmA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kvk PROTEIN KP700603

(Klebsiella
pneumoniae) 		PF02464
(CinA) 		4 SER A  82
ARG A 142
ARG A 140
ASP A 119
 None
 1.03A 5zw4A-5kvkA:
undetectable		 5zw4A-5kvkA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE DELTA
SUBUNIT
ACETOPHENONE
CARBOXYLASE GAMMA
SUBUNIT

(Aromatoleum
aromaticum;
Aromatoleum
aromaticum) 		PF02538
(Hydantoinase_B)
PF01968
(Hydantoinase_A)
PF05378
(Hydant_A_N) 		4 SER A  81
ARG B 117
ARG B 121
ASP A  46
 None
 1.27A 5zw4A-5l9wA:
undetectable		 5zw4A-5l9wA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nec TONB-DEPENDENT
SIDEROPHORE RECEPTOR

(Pseudomonas
aeruginosa) 		no annotation 4 SER A 625
GLU A 606
ARG A 578
ASP A 558
 None
 1.30A 5zw4A-5necA:
undetectable		 5zw4A-5necA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o60 50S RIBOSOMAL
PROTEIN L23
50S RIBOSOMAL
PROTEIN L29

(Mycolicibacterium
smegmatis;
Mycolicibacterium
smegmatis) 		PF00276
(Ribosomal_L23)
PF00831
(Ribosomal_L29) 		4 GLU Z  27
ARG Z  23
ARG U   8
ASP Z  20
 None
 1.25A 5zw4A-5o60Z:
undetectable		 5zw4A-5o60Z:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5z 3C10 FAB LIGHT CHAIN

(Rattus
norvegicus) 		no annotation 4 GLU L 184
ARG L 187
ASP L 156
ASP L 150
 None
 1.18A 5zw4A-5w5zL:
undetectable		 5zw4A-5w5zL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbp 3NT OXYGENASE ALPHA
SUBUNIT
3NT OXYGENASE BETA
SUBUNIT

(Diaphorobacter
sp. DS2;
Diaphorobacter
sp. DS2) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A)
PF00866
(Ring_hydroxyl_B) 		4 SER A 368
GLU C 150
ARG C 144
ARG C 147
 None
 1.22A 5zw4A-5xbpA:
undetectable		 5zw4A-5xbpA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnm PHOTOSYSTEM II CP47
REACTION CENTER
PROTEIN

(Pisum sativum) 		no annotation 4 SER B 289
GLU B 353
ARG B 352
ASP B 372
 None
 1.10A 5zw4A-5xnmB:
undetectable		 5zw4A-5xnmB:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yfb DIPEPTIDYL PEPTIDASE
3

(Armillaria
tabescens) 		no annotation 4 SER A 497
GLU A 494
ARG A 631
ASP A 489
 None
 1.27A 5zw4A-5yfbA:
undetectable		 5zw4A-5yfbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ze4 DIHYDROXY-ACID
DEHYDRATASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		no annotation 4 SER A 567
ARG A 527
ASP A 529
ASP A 405
 None
 1.13A 5zw4A-5ze4A:
undetectable		 5zw4A-5ze4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zln TOLL-LIKE RECEPTOR 9

(Mus musculus) 		no annotation 4 SER A 342
GLU A 368
ARG A 337
ASP A 314
 None
None
SO4  A 919 (-3.7A)
None
 1.26A 5zw4A-5zlnA:
undetectable		 5zw4A-5zlnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zqj BETA-XYLOSIDASE

(Bacillus
pumilus) 		no annotation 4 SER A  59
GLU A 114
ASP A 109
ASP A 117
 None
 1.21A 5zw4A-5zqjA:
undetectable		 5zw4A-5zqjA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5zw4 PUTATIVE
O-METHYLTRANSFERASE
YRRM

(Bacillus
subtilis) 		no annotation 4 GLU A  85
ARG A  86
ARG A  90
ASP A 113
 SAM  A 302 (-2.7A)
None
U  D  34 (-2.9A)
SAM  A 302 (-3.3A)
 1.12A 5zw4A-5zw4A:
41.4		 5zw4A-5zw4A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5zw4 PUTATIVE
O-METHYLTRANSFERASE
YRRM

(Bacillus
subtilis) 		no annotation 5 SER A  68
GLU A  85
ARG A  90
ASP A 113
ASP A 133
 SAM  A 302 (-2.7A)
SAM  A 302 (-2.7A)
U  D  34 (-2.9A)
SAM  A 302 (-3.3A)
SAM  A 302 (-3.6A)
 0.00A 5zw4A-5zw4A:
41.4		 5zw4A-5zw4A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6asx DNA-DIRECTED RNA
POLYMERASE SUBUNIT
OMEGA

(Escherichia
coli) 		no annotation 4 GLU K  53
ARG K  52
ASP K  44
ASP K  36
 None
 1.25A 5zw4A-6asxK:
undetectable		 5zw4A-6asxK:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aun PLA2G6, IPLA2BETA

(Cricetulus
griseus) 		no annotation 4 SER A 503
ARG A 595
ARG A 578
ASP A 536
 None
 1.06A 5zw4A-6aunA:
undetectable		 5zw4A-6aunA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b2y SOLUTE-BINDING
PERIPLASMIC PROTEIN
OF IRON/SIDEROPHORE
ABC TRANSPORTER

(Yersinia pestis) 		no annotation 4 SER A 137
ARG A  26
ASP A  49
ASP A 125
 None
 0.95A 5zw4A-6b2yA:
undetectable		 5zw4A-6b2yA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6co7 PREDICTED PROTEIN

(Nematostella
vectensis) 		no annotation 4 SER A 910
ARG A 623
ARG A 619
ASP A 627
 None
 1.25A 5zw4A-6co7A:
undetectable		 5zw4A-6co7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fay ODZ3 PROTEIN

(Mus musculus) 		no annotation 4 SER A1331
ARG A1256
ASP A1243
ASP A1325
 None
 1.17A 5zw4A-6fayA:
undetectable		 5zw4A-6fayA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fkh ATP SYNTHASE SUBUNIT
BETA, CHLOROPLASTIC
ATP SYNTHASE GAMMA
CHAIN, CHLOROPLASTIC

(Spinacia
oleracea;
Spinacia
oleracea) 		no annotation
no annotation 		4 SER g 324
GLU D 400
ARG D 397
ASP D 417
 None
 1.21A 5zw4A-6fkhg:
undetectable		 5zw4A-6fkhg:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gpl GDP-MANNOSE 4,6
DEHYDRATASE

(Homo sapiens) 		no annotation 4 SER B 156
GLU B 328
ARG B 325
ASP B 244
 F7E  B 402 (-3.5A)
F7E  B 402 (-2.9A)
F7E  B 402 (-3.2A)
None
 1.18A 5zw4A-6gplB:
8.0		 5zw4A-6gplB:
undetectable