SIMILAR PATTERNS OF AMINO ACIDS FOR 5ZW2_A_ACTA511

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b1b PROTEIN (IRON
DEPENDENT REGULATOR)

(Mycobacterium
tuberculosis) 		PF01325
(Fe_dep_repress)
PF02742
(Fe_dep_repr_C) 		3 ARG A  80
ILE A 132
SER A 126
 SO4  A 303 (-4.0A)
None
SO4  A 303 ( 4.9A)
 0.85A 5zw2A-1b1bA:
0.0		 5zw2A-1b1bA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b7e PROTEIN (TRANSPOSASE
INHIBITOR PROTEIN
FROM TN5)

(Escherichia
coli) 		PF01609
(DDE_Tnp_1)
PF02281
(Dimer_Tnp_Tn5) 		3 ARG A  75
ILE A  74
SER A 354
 None
 0.84A 5zw2A-1b7eA:
0.0		 5zw2A-1b7eA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c0w DIPHTHERIA TOXIN
REPRESSOR

(Corynebacterium
diphtheriae) 		PF01325
(Fe_dep_repress)
PF02742
(Fe_dep_repr_C) 		3 ARG A  80
ILE A 132
SER A 126
 None
 0.76A 5zw2A-1c0wA:
0.0		 5zw2A-1c0wA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dl2 CLASS I
ALPHA-1,2-MANNOSIDAS
E

(Saccharomyces
cerevisiae) 		PF01532
(Glyco_hydro_47) 		3 ARG A 273
ILE A 254
SER A 272
 None
 0.55A 5zw2A-1dl2A:
0.0		 5zw2A-1dl2A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ex6 GUANYLATE KINASE

(Saccharomyces
cerevisiae) 		PF00625
(Guanylate_kin) 		3 ARG A 146
ILE A 143
SER A 142
 None
 0.88A 5zw2A-1ex6A:
0.0		 5zw2A-1ex6A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f0k UDP-N-ACETYLGLUCOSAM
INE-N-ACETYLMURAMYL-
(PENTAPEPTIDE)
PYROPHOSPHORYL-UNDEC
APRENOL
N-ACETYLGLUCOSAMINE
TRANSFERASE

(Escherichia
coli) 		PF03033
(Glyco_transf_28)
PF04101
(Glyco_tran_28_C) 		3 ARG A  80
ILE A  63
SER A  64
 None
 0.82A 5zw2A-1f0kA:
0.0		 5zw2A-1f0kA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)

(Allochromatium
vinosum) 		PF07992
(Pyr_redox_2)
PF09242
(FCSD-flav_bind) 		3 ARG A  53
ILE A  58
SER A  57
 None
 0.71A 5zw2A-1fcdA:
0.0		 5zw2A-1fcdA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fiu TYPE II RESTRICTION
ENZYME NGOMI

(Neisseria
gonorrhoeae) 		PF09015
(NgoMIV_restric) 		3 ARG A 227
ILE A 190
SER A 192
 None
 0.88A 5zw2A-1fiuA:
0.0		 5zw2A-1fiuA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fx7 IRON-DEPENDENT
REPRESSOR IDER

(Mycobacterium
tuberculosis) 		PF01325
(Fe_dep_repress)
PF02742
(Fe_dep_repr_C)
PF04023
(FeoA) 		3 ARG A  80
ILE A 132
SER A 126
 None
 0.79A 5zw2A-1fx7A:
0.0		 5zw2A-1fx7A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h6g ALPHA-1 CATENIN

(Homo sapiens) 		PF01044
(Vinculin) 		3 ARG A 548
ILE A 519
SER A 515
 None
 0.71A 5zw2A-1h6gA:
3.5		 5zw2A-1h6gA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hxj BETA-GLUCOSIDASE

(Zea mays) 		PF00232
(Glyco_hydro_1) 		3 ARG A 425
ILE A 429
SER A 486
 None
 0.82A 5zw2A-1hxjA:
undetectable		 5zw2A-1hxjA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hzn CHOLECYSTOKININ TYPE
A RECEPTOR

(Homo sapiens) 		no annotation 3 ARG A  18
ILE A  25
SER A  21
 None
 0.84A 5zw2A-1hznA:
undetectable		 5zw2A-1hznA:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ib1 SEROTONIN
N-ACETYLTRANSFERASE

(Ovis aries) 		PF00583
(Acetyltransf_1) 		3 ARG E  28
ILE E  20
SER E  18
 TPO  E  31 ( 4.8A)
None
None
 0.81A 5zw2A-1ib1E:
undetectable		 5zw2A-1ib1E:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ixk METHYLTRANSFERASE

(Pyrococcus
horikoshii) 		PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N) 		3 ARG A  45
ILE A  89
SER A  88
 None
 0.84A 5zw2A-1ixkA:
undetectable		 5zw2A-1ixkA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jj4 REGULATORY PROTEIN
E2

(Alphapapillomavirus
7) 		PF00511
(PPV_E2_C) 		3 ARG A 303
ILE A 316
SER A 317
 None
 0.88A 5zw2A-1jj4A:
undetectable		 5zw2A-1jj4A:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lw7 TRANSCRIPTIONAL
REGULATOR NADR

(Haemophilus
influenzae) 		PF01467
(CTP_transf_like)
PF13521
(AAA_28) 		3 ARG A 389
ILE A 381
SER A 383
 None
 0.83A 5zw2A-1lw7A:
undetectable		 5zw2A-1lw7A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nze OXYGEN-EVOLVING
ENHANCER PROTEIN 3

(Spinacia
oleracea) 		PF05757
(PsbQ) 		3 ARG A  81
ILE A  59
SER A  55
 None
 0.68A 5zw2A-1nzeA:
undetectable		 5zw2A-1nzeA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1olx 2-OXOISOVALERATE
DEHYDROGENASE BETA
SUBUNIT

(Homo sapiens) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		3 ARG B 309
ILE B 277
SER B 292
 None
 0.88A 5zw2A-1olxB:
undetectable		 5zw2A-1olxB:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhh PROTEIN (PCRA
(SUBUNIT))

(Geobacillus
stearothermophilus) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		3 ARG B 413
ILE B 414
SER B 410
 None
 0.83A 5zw2A-1qhhB:
undetectable		 5zw2A-1qhhB:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rlk HYPOTHETICAL PROTEIN
TA0108

(Thermoplasma
acidophilum) 		PF01981
(PTH2) 		3 ARG A  34
ILE A  38
SER A  35
 None
 0.81A 5zw2A-1rlkA:
undetectable		 5zw2A-1rlkA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rx0 ACYL-COA
DEHYDROGENASE FAMILY
MEMBER 8,
MITOCHONDRIAL

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		3 ARG A 236
ILE A 196
SER A 194
 EDO  A2011 (-3.1A)
None
None
 0.79A 5zw2A-1rx0A:
53.3		 5zw2A-1rx0A:
29.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sjp 60 KDA CHAPERONIN 2

(Mycobacterium
tuberculosis) 		PF00118
(Cpn60_TCP1) 		3 ARG A 359
ILE A 350
SER A 353
 None
 0.77A 5zw2A-1sjpA:
undetectable		 5zw2A-1sjpA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1s 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Escherichia
coli) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		3 ARG A 190
ILE A 249
SER A 185
 None
None
SO4  A1001 (-2.5A)
 0.77A 5zw2A-1t1sA:
undetectable		 5zw2A-1t1sA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ten TENASCIN

(Homo sapiens) 		PF00041
(fn3) 		3 ARG A 876
ILE A 874
SER A 881
 None
 0.88A 5zw2A-1tenA:
undetectable		 5zw2A-1tenA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tff UBIQUITIN
THIOLESTERASE
PROTEIN OTUB2

(Homo sapiens) 		PF10275
(Peptidase_C65) 		3 ARG A  43
ILE A   9
SER A  10
 None
 0.71A 5zw2A-1tffA:
undetectable		 5zw2A-1tffA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v02 DHURRINASE

(Sorghum bicolor) 		PF00232
(Glyco_hydro_1) 		3 ARG A 426
ILE A 430
SER A 487
 None
 0.86A 5zw2A-1v02A:
undetectable		 5zw2A-1v02A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4g GLUTAMATE--CYSTEINE
LIGASE

(Escherichia
coli) 		PF04262
(Glu_cys_ligase) 		3 ARG A 235
ILE A 146
SER A 103
 None
 0.81A 5zw2A-1v4gA:
undetectable		 5zw2A-1v4gA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4g GLUTAMATE--CYSTEINE
LIGASE

(Escherichia
coli) 		PF04262
(Glu_cys_ligase) 		3 ARG A 235
ILE A 146
SER A 147
 None
 0.81A 5zw2A-1v4gA:
undetectable		 5zw2A-1v4gA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve1 O-ACETYLSERINE
SULFHYDRYLASE

(Thermus
thermophilus) 		PF00291
(PALP) 		3 ARG A  84
ILE A  80
SER A  83
 None
 0.72A 5zw2A-1ve1A:
undetectable		 5zw2A-1ve1A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x6e ZINC FINGER PROTEIN
24

(Homo sapiens) 		PF00096
(zf-C2H2) 		3 ARG A  26
ILE A  29
SER A  25
 None
 0.78A 5zw2A-1x6eA:
undetectable		 5zw2A-1x6eA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xcv DIPHTHERIA TOXIN
REPRESSOR MUTANT

(Corynebacterium
diphtheriae) 		PF01325
(Fe_dep_repress)
PF02742
(Fe_dep_repr_C) 		3 ARG A  80
ILE A 132
SER A 126
 None
 0.79A 5zw2A-1xcvA:
undetectable		 5zw2A-1xcvA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ylo HYPOTHETICAL PROTEIN
SF2450

(Shigella
flexneri) 		PF05343
(Peptidase_M42) 		3 ARG A 145
ILE A  15
SER A  18
 None
 0.76A 5zw2A-1yloA:
undetectable		 5zw2A-1yloA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a0l 33H1 FV FRAGMENT

(Mus musculus) 		PF07686
(V-set) 		3 ARG D  67
ILE D  68
SER D  66
 None
 0.83A 5zw2A-2a0lD:
undetectable		 5zw2A-2a0lD:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT

(Homo sapiens) 		PF00753
(Lactamase_B)
PF07521
(RMMBL)
PF10996
(Beta-Casp) 		3 ARG A 218
ILE A 391
SER A 392
 None
 0.81A 5zw2A-2i7tA:
undetectable		 5zw2A-2i7tA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2it0 IRON-DEPENDENT
REPRESSOR IDER

(Mycobacterium
tuberculosis) 		PF01325
(Fe_dep_repress)
PF02742
(Fe_dep_repr_C) 		3 ARG A  80
ILE A 132
SER A 126
 ACT  A2001 ( 4.7A)
None
ACT  A2001 ( 4.5A)
 0.82A 5zw2A-2it0A:
undetectable		 5zw2A-2it0A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kiw INT PROTEIN

(Staphylococcus
haemolyticus) 		PF14659
(Phage_int_SAM_3) 		3 ARG A  88
ILE A 131
SER A 130
 None
 0.58A 5zw2A-2kiwA:
undetectable		 5zw2A-2kiwA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2onk MOLYBDATE/TUNGSTATE
ABC TRANSPORTER,
PERMEASE PROTEIN

(Archaeoglobus
fulgidus) 		PF00528
(BPD_transp_1) 		3 ARG C 195
ILE C 142
SER C 139
 None
 0.86A 5zw2A-2onkC:
undetectable		 5zw2A-2onkC:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p7v REGULATOR OF SIGMA D

(Escherichia
coli) 		PF04353
(Rsd_AlgQ) 		3 ARG A  75
ILE A  72
SER A  71
 None
 0.84A 5zw2A-2p7vA:
undetectable		 5zw2A-2p7vA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wgp DUAL SPECIFICITY
PROTEIN PHOSPHATASE
14

(Homo sapiens) 		PF00782
(DSPc) 		3 ARG A 163
ILE A 159
SER A 169
 None
 0.87A 5zw2A-2wgpA:
undetectable		 5zw2A-2wgpA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzg GLUCOSYLTRANSFERASE

(Legionella
pneumophila) 		PF16849
(Glyco_transf_88) 		3 ARG A 286
ILE A 276
SER A 277
 None
 0.76A 5zw2A-2wzgA:
undetectable		 5zw2A-2wzgA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xal INOSITOL-PENTAKISPHO
SPHATE 2-KINASE

(Arabidopsis
thaliana) 		PF06090
(Ins_P5_2-kin) 		3 ARG A 283
ILE A 276
SER A 278
 None
 0.83A 5zw2A-2xalA:
undetectable		 5zw2A-2xalA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xpz LEUKOTRIENE A-4
HYDROLASE

(Saccharomyces
cerevisiae) 		PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C) 		3 ARG A  48
ILE A  45
SER A  44
 None
 0.81A 5zw2A-2xpzA:
undetectable		 5zw2A-2xpzA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xu0 ERYTHROCYTE MEMBRANE
PROTEIN 1

(Plasmodium
falciparum) 		PF05424
(Duffy_binding)
PF15447
(NTS) 		3 ARG A 134
ILE A 172
SER A 191
 None
 0.86A 5zw2A-2xu0A:
2.0		 5zw2A-2xu0A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0k UPF0064 PROTEIN YCCW

(Escherichia
coli) 		PF10672
(Methyltrans_SAM) 		3 ARG A  52
ILE A  74
SER A  73
 None
 0.81A 5zw2A-3c0kA:
undetectable		 5zw2A-3c0kA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ect HEXAPEPTIDE-REPEAT
CONTAINING-ACETYLTRA
NSFERASE

(Vibrio cholerae) 		PF00132
(Hexapep)
PF12464
(Mac) 		3 ARG A  45
ILE A  36
SER A  39
 None
 0.77A 5zw2A-3ectA:
undetectable		 5zw2A-3ectA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f9t L-TYROSINE
DECARBOXYLASE MFNA

(Methanocaldococcus
jannaschii) 		PF00282
(Pyridoxal_deC) 		3 ARG A 357
ILE A 389
SER A 392
 None
 0.88A 5zw2A-3f9tA:
undetectable		 5zw2A-3f9tA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fes ATP-DEPENDENT CLP
ENDOPEPTIDASE

(Clostridioides
difficile) 		PF02861
(Clp_N) 		3 ARG A  82
ILE A  86
SER A  30
 None
 0.84A 5zw2A-3fesA:
undetectable		 5zw2A-3fesA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ga2 ENDONUCLEASE V

(Bacillus
subtilis) 		PF04493
(Endonuclease_5) 		3 ARG A  94
ILE A  82
SER A  83
 None
 0.78A 5zw2A-3ga2A:
undetectable		 5zw2A-3ga2A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2b SAM-DEPENDENT
METHYLTRANSFERASE

(Corynebacterium
glutamicum) 		PF13649
(Methyltransf_25) 		3 ARG A  88
ILE A  81
SER A  82
 None
 0.86A 5zw2A-3h2bA:
undetectable		 5zw2A-3h2bA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icq EXPORTIN-T

(Schizosaccharomyces
pombe) 		PF08389
(Xpo1) 		3 ARG T 362
ILE T 426
SER T 425
 U  D  68 ( 3.7A)
None
None
 0.78A 5zw2A-3icqT:
undetectable		 5zw2A-3icqT:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3inz PROTEIN HFQ

(Pseudomonas
aeruginosa) 		PF17209
(Hfq) 		3 ARG A  16
ILE A  36
SER A  38
 None
 0.66A 5zw2A-3inzA:
undetectable		 5zw2A-3inzA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3juy 3B3 SINGLE CHAIN
VARIANT HIV-1
ANTIBODY

(Homo sapiens) 		no annotation 3 ARG B 197
ILE B 201
SER B 202
 None
 0.77A 5zw2A-3juyB:
undetectable		 5zw2A-3juyB:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mru AMINOACYL-HISTIDINE
DIPEPTIDASE

(Vibrio
alginolyticus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		3 ARG A 376
ILE A 368
SER A 370
 None
 0.74A 5zw2A-3mruA:
undetectable		 5zw2A-3mruA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n01 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE-LIKE N

(Homo sapiens) 		PF11548
(Receptor_IA-2) 		3 ARG A 519
ILE A 505
SER A 503
 None
 0.63A 5zw2A-3n01A:
undetectable		 5zw2A-3n01A:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzt GLUTAMATE--CYSTEINE
LIGASE

(Francisella
tularensis) 		PF04262
(Glu_cys_ligase) 		3 ARG A 215
ILE A 133
SER A  91
 SO4  A 507 (-3.8A)
None
None
 0.83A 5zw2A-3nztA:
undetectable		 5zw2A-3nztA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzt GLUTAMATE--CYSTEINE
LIGASE

(Francisella
tularensis) 		PF04262
(Glu_cys_ligase) 		3 ARG A 215
ILE A 133
SER A 134
 SO4  A 507 (-3.8A)
None
None
 0.83A 5zw2A-3nztA:
undetectable		 5zw2A-3nztA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8a UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF13468
(Glyoxalase_3) 		3 ARG A 269
ILE A 267
SER A 260
 None
 0.88A 5zw2A-3p8aA:
undetectable		 5zw2A-3p8aA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3phf ENVELOPE
GLYCOPROTEIN L

(Human
gammaherpesvirus
4) 		no annotation 3 ARG B  95
ILE B  92
SER B  91
 None
 0.84A 5zw2A-3phfB:
undetectable		 5zw2A-3phfB:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6g SH2
DOMAIN-CONTAINING
PROTEIN 3C

(Homo sapiens) 		PF00617
(RasGEF) 		3 ARG A 504
ILE A 494
SER A 497
 None
 0.72A 5zw2A-3t6gA:
undetectable		 5zw2A-3t6gA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va6 TWO-COMPONENT SYSTEM
SENSOR HISTIDINE
KINASE

(Bacteroides
thetaiotaomicron) 		PF07494
(Reg_prop)
PF07495
(Y_Y_Y) 		3 ARG A 611
ILE A 598
SER A 597
 None
 0.89A 5zw2A-3va6A:
undetectable		 5zw2A-3va6A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wap AUTOPHAGY-RELATED
PROTEIN 13,
MICROTUBULE-ASSOCIAT
ED PROTEINS 1A/1B
LIGHT CHAIN 3C

(Homo sapiens) 		PF02991
(Atg8) 		3 ARG A  85
ILE A  82
SER A  84
 None
 0.85A 5zw2A-3wapA:
undetectable		 5zw2A-3wapA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dws CHI2

(Yersinia
entomophaga) 		PF00704
(Glyco_hydro_18) 		3 ARG A 195
ILE A 197
SER A 154
 None
 0.88A 5zw2A-4dwsA:
undetectable		 5zw2A-4dwsA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4go5 ASPARTOKINASE

(Mycobacterium
tuberculosis) 		PF01842
(ACT)
PF13840
(ACT_7) 		3 ARG X 135
ILE X 101
SER X  99
 None
 0.82A 5zw2A-4go5X:
undetectable		 5zw2A-4go5X:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igg CATENIN ALPHA-1

(Homo sapiens) 		PF01044
(Vinculin) 		3 ARG A 548
ILE A 519
SER A 515
 None
 0.54A 5zw2A-4iggA:
2.2		 5zw2A-4iggA:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3b M1 FAMILY
AMINOPEPTIDASE

(Plasmodium
falciparum) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		3 ARG A 751
ILE A 771
SER A 767
 None
 0.79A 5zw2A-4j3bA:
undetectable		 5zw2A-4j3bA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jkm BETA-GLUCURONIDASE

(Clostridium
perfringens) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		3 ARG A 329
ILE A 351
SER A 408
 None
 0.85A 5zw2A-4jkmA:
undetectable		 5zw2A-4jkmA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kr9 PROBABLE TRNA
SULFURTRANSFERASE

(Thermotoga
maritima) 		PF02568
(ThiI)
PF02926
(THUMP) 		3 ARG A 265
ILE A 303
SER A 302
 None
 0.85A 5zw2A-4kr9A:
undetectable		 5zw2A-4kr9A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lsu LIGHT CHAIN OF
ANTIBODY VRC-PG20

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 ARG L  54
ILE L  58
SER L  59
 None
 0.89A 5zw2A-4lsuL:
undetectable		 5zw2A-4lsuL:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo sapiens) 		PF01728
(FtsJ) 		3 ARG A 346
ILE A 394
SER A 393
 None
 0.87A 5zw2A-4n49A:
undetectable		 5zw2A-4n49A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p4g SHIKIMATE
5-DEHYDROGENASE AROE
(5-DEHYDROSHIKIMATE
REDUCTASE)

(Mycobacterium
tuberculosis) 		PF08501
(Shikimate_dh_N) 		3 ARG A  40
ILE A  15
SER A  18
 None
None
SKM  A 301 (-2.4A)
 0.75A 5zw2A-4p4gA:
undetectable		 5zw2A-4p4gA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rav SINGLE-CHAIN FV, VL

(Homo sapiens) 		PF07686
(V-set) 		3 ARG B 183
ILE B 187
SER B 188
 None
None
SO4  B 301 (-2.8A)
 0.68A 5zw2A-4ravB:
undetectable		 5zw2A-4ravB:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4re2 BETA-MANNOSIDASE/BET
A-GLUCOSIDASE

(Oryza sativa) 		PF00232
(Glyco_hydro_1) 		3 ARG A 265
ILE A 290
SER A 286
 None
 0.84A 5zw2A-4re2A:
undetectable		 5zw2A-4re2A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1

(Homo sapiens;
synthetic
construct) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		3 ARG A1726
ILE A1727
SER A1723
 None
 0.88A 5zw2A-4rh7A:
undetectable		 5zw2A-4rh7A:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rl1 TYPE I POLYKETIDE
SYNTHASE AVES 1

(Streptomyces
avermitilis) 		PF00698
(Acyl_transf_1) 		3 ARG A 218
ILE A 220
SER A 160
 None
 0.82A 5zw2A-4rl1A:
undetectable		 5zw2A-4rl1A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus musculus) 		PF00069
(Pkinase) 		3 ARG B 256
ILE B 250
SER B 252
 None
 0.84A 5zw2A-4tyhB:
undetectable		 5zw2A-4tyhB:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xe7 UNCHARACTERIZED
PROTEIN

(Bacillus
thuringiensis) 		no annotation 3 ARG A  87
ILE A  78
SER A  79
 None
 0.89A 5zw2A-4xe7A:
undetectable		 5zw2A-4xe7A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xkq NICKEL ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Staphylococcus
aureus) 		PF00496
(SBP_bac_5) 		3 ARG A 196
ILE A 208
SER A  14
 None
 0.72A 5zw2A-4xkqA:
undetectable		 5zw2A-4xkqA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y91 RNA-BINDING PROTEIN
HFQ

(Thermotoga
maritima) 		PF17209
(Hfq) 		3 ARG A  18
ILE A  38
SER A  40
 None
 0.75A 5zw2A-4y91A:
undetectable		 5zw2A-4y91A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c5z GLUTAMYL-TRNA
AMIDOTRANSFERASE

(Escherichia
coli) 		no annotation 3 ARG A 111
ILE A 113
SER A  43
 None
 0.84A 5zw2A-5c5zA:
undetectable		 5zw2A-5c5zA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci5 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1

(Pseudothermotoga
lettingae) 		PF13416
(SBP_bac_8) 		3 ARG A 248
ILE A 269
SER A 265
 None
 0.64A 5zw2A-5ci5A:
undetectable		 5zw2A-5ci5A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ck0 SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 ARG A 413
ILE A 410
SER A 412
 None
 0.85A 5zw2A-5ck0A:
undetectable		 5zw2A-5ck0A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5edj FRPC OPERON PROTEIN

(Neisseria
meningitidis) 		PF06901
(FrpC) 		3 ARG A 240
ILE A 239
SER A 139
 None
 0.81A 5zw2A-5edjA:
undetectable		 5zw2A-5edjA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f89 CAP248-2B LIGHT
CHAIN

(Homo sapiens) 		no annotation 3 ARG L  54
ILE L  58
SER L  59
 None
 0.81A 5zw2A-5f89L:
undetectable		 5zw2A-5f89L:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ft6 CYSTEINE DESULFURASE
CSDA

(Escherichia
coli) 		PF00266
(Aminotran_5) 		3 ARG A  64
ILE A 280
SER A 283
 GOL  A 503 (-4.5A)
None
None
 0.71A 5zw2A-5ft6A:
undetectable		 5zw2A-5ft6A:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5m ALPHA-CATENIN-LIKE
PROTEIN HMP-1

(Caenorhabditis
elegans) 		PF01044
(Vinculin) 		3 ARG A 551
ILE A 513
SER A 509
 None
 0.50A 5zw2A-5h5mA:
3.1		 5zw2A-5h5mA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mau CHLORITE DISMUTASE

(Cyanothece sp.
PCC 7425) 		no annotation 3 ARG A  51
ILE A   8
SER A   6
 None
 0.62A 5zw2A-5mauA:
undetectable		 5zw2A-5mauA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlc 50S RIBOSOMAL
PROTEIN L19,
CHLOROPLASTIC

(Spinacia
oleracea) 		PF01245
(Ribosomal_L19) 		3 ARG R 182
ILE R 170
SER R 171
 G  A2702 ( 3.6A)
None
None
 0.79A 5zw2A-5mlcR:
undetectable		 5zw2A-5mlcR:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5szd RNA-BINDING PROTEIN
HFQ

(Aquifex
aeolicus) 		PF17209
(Hfq) 		3 ARG A  17
ILE A  37
SER A  39
 None
 0.72A 5zw2A-5szdA:
undetectable		 5zw2A-5szdA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udb CELL DIVISION CYCLE
PROTEIN CDT1

(Saccharomyces
cerevisiae) 		PF16679
(CDT1_C) 		3 ARG 8 117
ILE 8 114
SER 8 113
 None
 0.76A 5zw2A-5udb8:
undetectable		 5zw2A-5udb8:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL

(Homo sapiens) 		no annotation 3 ARG A 182
ILE A 188
SER A 187
 None
 0.83A 5zw2A-5v7iA:
undetectable		 5zw2A-5v7iA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdu BNAB 35O22 FAB LIGHT
CHAIN

(Homo sapiens) 		no annotation 3 ARG I  54
ILE I  58
SER I  59
 None
 0.55A 5zw2A-5wduI:
undetectable		 5zw2A-5wduI:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wrr PSEUDOKINASE FAM20A

(Homo sapiens) 		PF06702
(Fam20C) 		3 ARG A 227
ILE A 194
SER A 195
 None
 0.86A 5zw2A-5wrrA:
undetectable		 5zw2A-5wrrA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfl CATENIN ALPHA-2

(Mus musculus) 		no annotation 3 ARG A 546
ILE A 517
SER A 513
 None
 0.58A 5zw2A-5xflA:
3.0		 5zw2A-5xflA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bo6 -

(-) 		no annotation 3 ARG A 340
ILE A 362
SER A 421
 None
 0.82A 5zw2A-6bo6A:
undetectable		 5zw2A-6bo6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE

(Medicago
truncatula) 		no annotation 3 ARG A 220
ILE A 226
SER A 225
 None
 0.82A 5zw2A-6cczA:
undetectable		 5zw2A-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ck9 35O22 SCFV LIGHT
CHAIN PORTION

(Homo sapiens) 		no annotation 3 ARG E  54
ILE E  58
SER E  59
 None
 0.77A 5zw2A-6ck9E:
undetectable		 5zw2A-6ck9E:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en4 SPLICING FACTOR 3B
SUBUNIT 1

(Homo sapiens) 		no annotation 3 ARG C1238
ILE C1272
SER C1271
 None
 0.72A 5zw2A-6en4C:
undetectable		 5zw2A-6en4C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2

(Cyanidioschyzon
merolae) 		no annotation 3 ARG B 201
ILE B 197
SER B 200
 None
 0.85A 5zw2A-6fosB:
undetectable		 5zw2A-6fosB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fuy VINCULIN

(Homo sapiens) 		no annotation 3 ARG A 759
ILE A 730
SER A 726
 None
 0.77A 5zw2A-6fuyA:
3.4		 5zw2A-6fuyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gbc MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1

(Arabidopsis
thaliana) 		no annotation 3 ARG A 220
ILE A 195
SER A 197
 None
None
AMP  A 501 (-2.8A)
 0.81A 5zw2A-6gbcA:
undetectable		 5zw2A-6gbcA:
undetectable