SIMILAR PATTERNS OF AMINO ACIDS FOR 5ZVG_B_SAMB401_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a3g BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE

(Escherichia
coli) 		PF01063
(Aminotran_4) 		5 ALA A 123
PRO A  98
GLY A  38
ASP A   6
ALA A   5
 None
 0.95A 5zvgB-1a3gA:
undetectable		 5zvgB-1a3gA:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5z L-LACTATE
DEHYDROGENASE

(Thermotoga
maritima) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ALA A 251
GLY A  30
SER A 163
ASP A 256
ALA A 255
 None
NAD  A 352 (-2.6A)
None
None
None
 1.20A 5zvgB-1a5zA:
6.9		 5zvgB-1a5zA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bdb CIS-BIPHENYL-2,3-DIH
YDRODIOL-2,3-DEHYDRO
GENASE

(Pseudomonas sp.) 		PF00106
(adh_short) 		5 ALA A  87
LYS A  37
SER A  38
ASP A  59
ARG A  61
 NAD  A 300 ( 3.8A)
NAD  A 300 (-4.4A)
None
NAD  A 300 (-3.2A)
NAD  A 300 ( 4.6A)
 1.16A 5zvgB-1bdbA:
6.5		 5zvgB-1bdbA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bdy PROTEIN KINASE C

(Rattus
norvegicus) 		no annotation 5 PRO A  53
ASP A  79
ALA A  76
ARG A  75
PRO A  26
 None
 1.30A 5zvgB-1bdyA:
undetectable		 5zvgB-1bdyA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)

(Geobacillus
stearothermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		5 ALA A 193
PRO A 105
GLY A  76
LYS A 108
ALA A 191
 None
None
None
PO4  A2001 ( 2.8A)
None
 1.10A 5zvgB-1brwA:
undetectable		 5zvgB-1brwA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bw0 PROTEIN (TYROSINE
AMINOTRANSFERASE)

(Trypanosoma
cruzi) 		PF00155
(Aminotran_1_2) 		5 PRO A 340
GLY A 342
SER A 348
ALA A 384
PRO A 159
 None
 1.30A 5zvgB-1bw0A:
undetectable		 5zvgB-1bw0A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d0q DNA PRIMASE

(Geobacillus
stearothermophilus) 		PF01807
(zf-CHC2) 		5 PRO A  48
SER A  51
ALA A  66
PRO A  41
PHE A  42
 None
 1.33A 5zvgB-1d0qA:
undetectable		 5zvgB-1d0qA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dp2 RHODANESE

(Bos taurus) 		PF00581
(Rhodanese) 		5 ALA A 257
PRO A 266
GLY A 264
ALA A 253
ARG A 110
 None
 1.28A 5zvgB-1dp2A:
undetectable		 5zvgB-1dp2A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1izc MACROPHOMATE
SYNTHASE
INTERMOLECULAR
DIELS-ALDERASE

(Macrophoma
commelinae) 		PF03328
(HpcH_HpaI) 		5 ALA A  84
PRO A  51
GLY A  74
LYS A  57
ALA A  88
 None
 1.29A 5zvgB-1izcA:
undetectable		 5zvgB-1izcA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1khd ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Pectobacterium
carotovorum) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		5 ALA A 197
PRO A  78
ALA A 118
PRO A  82
TYR A  84
 None
 1.06A 5zvgB-1khdA:
undetectable		 5zvgB-1khdA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogp SULFITE OXIDASE

(Arabidopsis
thaliana) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		5 ALA A 353
GLY A 307
SER A 380
ALA A 355
TYR A 289
 None
 1.24A 5zvgB-1ogpA:
undetectable		 5zvgB-1ogpA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qs0 2-OXOISOVALERATE
DEHYDROGENASE
BETA-SUBUNIT

(Pseudomonas
putida) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 ALA B  11
SER B 200
ASP B 155
ALA B 156
TYR B 207
 None
 1.29A 5zvgB-1qs0B:
undetectable		 5zvgB-1qs0B:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rfy TRANSCRIPTIONAL
REPRESSOR TRAM

(Agrobacterium
tumefaciens) 		PF09228
(Prok-TraM) 		5 LYS A  10
ASP A  35
ALA A  36
ARG A  38
PRO A  97
 None
 1.30A 5zvgB-1rfyA:
undetectable		 5zvgB-1rfyA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6r CREATINE KINASE, M
CHAIN

(Oryctolagus
cuniculus) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		5 LYS A 176
SER A 177
ASP A 212
ALA A 213
ARG A 151
 None
 1.29A 5zvgB-1u6rA:
undetectable		 5zvgB-1u6rA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uqw PUTATIVE BINDING
PROTEIN YLIB

(Escherichia
coli) 		PF00496
(SBP_bac_5) 		5 GLY A  38
SER A 389
ASP A 394
ALA A 130
PHE A 128
 None
 1.08A 5zvgB-1uqwA:
undetectable		 5zvgB-1uqwA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4v UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Thermus
thermophilus) 		PF02350
(Epimerase_2) 		5 ALA A  18
GLY A  42
ALA A  22
TYR A 265
PHE A  55
 None
 1.21A 5zvgB-1v4vA:
undetectable		 5zvgB-1v4vA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve3 HYPOTHETICAL PROTEIN
PH0226

(Pyrococcus
horikoshii) 		PF13649
(Methyltransf_25) 		7 ALA A  46
GLY A  51
SER A  69
ASP A  93
ALA A  94
ARG A  95
PHE A 116
 SAM  A 302 (-3.4A)
None
SAM  A 302 (-4.7A)
SAM  A 302 (-3.4A)
SAM  A 302 (-3.3A)
None
SAM  A 302 (-4.4A)
 1.20A 5zvgB-1ve3A:
13.3		 5zvgB-1ve3A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wel RNA-BINDING PROTEIN
12

(Homo sapiens) 		PF00076
(RRM_1) 		5 ALA A 463
PRO A 466
GLY A 468
TYR A 433
PHE A 475
 None
 1.35A 5zvgB-1welA:
undetectable		 5zvgB-1welA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wnb PUTATIVE BETAINE
ALDEHYDE
DEHYDROGENASE

(Escherichia
coli) 		PF00171
(Aldedh) 		6 ALA A 164
PRO A 138
GLY A  56
ALA A 114
PRO A 161
PHE A 111
 None
 1.34A 5zvgB-1wnbA:
undetectable		 5zvgB-1wnbA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wpx CARBOXYPEPTIDASE Y
INHIBITOR

(Saccharomyces
cerevisiae) 		PF01161
(PBP) 		5 ALA B 716
PRO B 655
GLY B 657
ALA B 557
PHE B 714
 None
 1.33A 5zvgB-1wpxB:
undetectable		 5zvgB-1wpxB:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfk FORMIMIDOYLGLUTAMASE

(Vibrio cholerae) 		PF00491
(Arginase) 		5 ALA A 130
GLY A 136
ASP A 254
ALA A 299
PRO A 179
 None
 1.28A 5zvgB-1xfkA:
undetectable		 5zvgB-1xfkA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkw FE(III)-PYOCHELIN
RECEPTOR

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 ALA A 340
GLY A 346
ARG A 655
PRO A 700
TYR A 654
 None
 1.17A 5zvgB-1xkwA:
undetectable		 5zvgB-1xkwA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cex PROTEIN HI0146

(Haemophilus
influenzae) 		PF03480
(DctP) 		5 ALA A  82
GLY A 125
ALA A  79
PRO A  84
TYR A 282
 None
 1.19A 5zvgB-2cexA:
undetectable		 5zvgB-2cexA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2col BIFUNCTIONAL
HEMOLYSIN-ADENYLATE
CYCLASE

(Bordetella
pertussis) 		PF03497
(Anthrax_toxA) 		5 GLY A 143
LYS A  65
SER A  66
ASP A  99
ALA A  96
 None
POP  A 893 (-2.4A)
None
None
None
 0.96A 5zvgB-2colA:
undetectable		 5zvgB-2colA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2deo 441AA LONG
HYPOTHETICAL NFED
PROTEIN

(Pyrococcus
horikoshii) 		PF00574
(CLP_protease) 		5 ALA A  93
PRO A  63
GLY A  31
LYS A  30
ALA A 112
 None
 1.34A 5zvgB-2deoA:
undetectable		 5zvgB-2deoA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE

(Escherichia
coli) 		PF01557
(FAA_hydrolase) 		5 GLY A 170
SER A 263
ASP A 255
ALA A 190
PRO A 136
 None
 1.32A 5zvgB-2eb5A:
undetectable		 5zvgB-2eb5A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ffu POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 2

(Homo sapiens) 		PF00535
(Glycos_transf_2)
PF00652
(Ricin_B_lectin) 		5 ALA A 151
GLY A 358
ALA A 148
ARG A 149
TYR A  86
 None
 1.18A 5zvgB-2ffuA:
undetectable		 5zvgB-2ffuA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fhp METHYLASE, PUTATIVE

(Enterococcus
faecalis) 		PF03602
(Cons_hypoth95) 		5 GLY A  54
LYS A  72
ASP A  99
ALA A 100
PRO A 122
 None
 1.06A 5zvgB-2fhpA:
12.8		 5zvgB-2fhpA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli) 		PF01189
(Methyltr_RsmB-F)
PF13636
(Methyltranf_PUA)
PF17125
(Methyltr_RsmF_N) 		5 ALA A 125
PRO A 128
SER A 151
ARG A 178
PRO A 196
 None
 0.90A 5zvgB-2frxA:
34.6		 5zvgB-2frxA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli) 		PF01189
(Methyltr_RsmB-F)
PF13636
(Methyltranf_PUA)
PF17125
(Methyltr_RsmF_N) 		5 PRO A 128
LYS A 131
SER A 151
ARG A 178
PRO A 196
 None
 1.06A 5zvgB-2frxA:
34.6		 5zvgB-2frxA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hcz BETA-EXPANSIN 1A

(Zea mays) 		PF01357
(Pollen_allerg_1)
PF03330
(DPBB_1) 		5 ALA X 169
GLY X 145
ASP X 173
ARG X 137
TYR X  15
 None
 1.29A 5zvgB-2hczX:
undetectable		 5zvgB-2hczX:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ibu ACETYL-COA
ACETYLTRANSFERASE

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 ALA A 355
GLY A 415
SER A 411
ALA A 380
TYR A 214
 COA  A6001 (-3.6A)
CSO  A 126 ( 4.2A)
None
None
None
 1.15A 5zvgB-2ibuA:
undetectable		 5zvgB-2ibuA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogx MOLYBDENUM STORAGE
PROTEIN SUBUNIT
ALPHA

(Azotobacter
vinelandii) 		PF00696
(AA_kinase) 		5 PRO A 154
ALA A  84
ARG A  85
PRO A 166
PHE A  88
 None
None
ATP  A 281 (-4.2A)
None
None
 1.28A 5zvgB-2ogxA:
undetectable		 5zvgB-2ogxA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		5 ALA A 178
GLY A 183
ASP A 243
ARG A 265
PRO A 261
 SAM  A 500 (-3.4A)
SAM  A 500 (-3.2A)
SAM  A 500 (-3.3A)
SAM  A 500 ( 4.6A)
SAM  A 500 (-4.1A)
 1.10A 5zvgB-2okcA:
10.3		 5zvgB-2okcA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		5 ALA A 178
GLY A 183
ASP A 243
PRO A 261
PHE A 288
 SAM  A 500 (-3.4A)
SAM  A 500 (-3.2A)
SAM  A 500 (-3.3A)
SAM  A 500 (-4.1A)
SAM  A 500 (-4.8A)
 0.78A 5zvgB-2okcA:
10.3		 5zvgB-2okcA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qcm URIDINE
5'-MONOPHOSPHATE
SYNTHASE (UMP
SYNTHASE)

(Homo sapiens) 		PF00215
(OMPdecase) 		5 ALA A 342
GLY A 399
SER A 348
ASP A 317
ALA A 316
 None
 1.35A 5zvgB-2qcmA:
undetectable		 5zvgB-2qcmA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rdy BH0842 PROTEIN

(Bacillus
halodurans) 		PF14498
(Glyco_hyd_65N_2) 		5 SER A 367
ASP A 425
ALA A 424
PRO A 350
PHE A 397
 None
 1.20A 5zvgB-2rdyA:
undetectable		 5zvgB-2rdyA:
20.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN

(Pyrococcus
horikoshii) 		PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N) 		8 ALA A 267
PRO A 270
GLY A 272
LYS A 273
ASP A 318
ALA A 319
ARG A 320
PRO A 339
 SFG  A5748 (-3.4A)
SFG  A5748 (-3.6A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.3A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.4A)
SFG  A5748 (-4.5A)
SFG  A5748 (-4.0A)
 0.32A 5zvgB-2yxlA:
38.5		 5zvgB-2yxlA:
32.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026

(Methanocaldococcus
jannaschii) 		PF01189
(Methyltr_RsmB-F) 		7 PRO A  94
GLY A  96
LYS A  97
SER A 117
ASP A 142
ARG A 144
PRO A 165
 SFG  A 500 (-3.9A)
SFG  A 500 (-3.5A)
SFG  A 500 (-2.8A)
None
SFG  A 500 (-4.0A)
None
SFG  A 500 (-3.9A)
 0.65A 5zvgB-3a4tA:
31.7		 5zvgB-3a4tA:
32.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3acz METHIONINE
GAMMA-LYASE

(Entamoeba
histolytica) 		PF01053
(Cys_Met_Meta_PP) 		5 ALA A 181
GLY A 304
SER A 202
ALA A 199
TYR A 149
 None
None
LLP  A 205 ( 2.8A)
None
None
 1.10A 5zvgB-3aczA:
3.9		 5zvgB-3aczA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3u 4-HYDROXYBUTYRATE
COA-TRANSFERASE

(Porphyromonas
gingivalis) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		5 GLY A 337
LYS A 101
SER A 138
ALA A 144
PHE A 110
 None
 1.27A 5zvgB-3d3uA:
2.7		 5zvgB-3d3uA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edl KINESIN13 MOTOR
DOMAIN

(Drosophila
melanogaster) 		PF00225
(Kinesin) 		5 ALA D 377
GLY D 165
ASP D 397
ALA D 396
PHE D 125
 None
ANP  D 500 ( 3.3A)
None
None
None
 1.33A 5zvgB-3edlD:
undetectable		 5zvgB-3edlD:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2u KINESIN-LIKE PROTEIN
KLP10A

(Drosophila
melanogaster) 		PF00225
(Kinesin) 		5 ALA K 585
GLY K 371
ASP K 605
ALA K 604
PHE K 331
 None
 1.35A 5zvgB-3j2uK:
undetectable		 5zvgB-3j2uK:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2u KINESIN-LIKE PROTEIN
KLP10A

(Drosophila
melanogaster) 		PF00225
(Kinesin) 		5 ALA K 585
GLY K 373
ASP K 605
ALA K 604
PHE K 331
 None
 1.26A 5zvgB-3j2uK:
undetectable		 5zvgB-3j2uK:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF2
PRE-MRNA-SPLICING
FACTOR CWF5

(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe) 		PF00076
(RRM_1)
PF16131
(Torus)
PF08082
(PRO8NT)
PF08083
(PROCN)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		5 ALA a  98
GLY a 106
ALA Y 266
ARG Y 265
TYR Y 174
 None
 1.22A 5zvgB-3jb9a:
undetectable		 5zvgB-3jb9a:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khp MAOC FAMILY PROTEIN

(Mycobacterium
tuberculosis) 		PF01575
(MaoC_dehydratas)
PF13452
(MaoC_dehydrat_N) 		5 ALA A 284
GLY A 260
ALA A 238
ARG A 239
PRO A 158
 None
 1.08A 5zvgB-3khpA:
undetectable		 5zvgB-3khpA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6x RRNA METHYLASE

(Thermus
thermophilus) 		PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N)
PF17126
(RsmF_methylt_CI) 		5 ALA A 109
PRO A 112
GLY A 114
LYS A 115
PRO A 179
 None
 0.43A 5zvgB-3m6xA:
35.5		 5zvgB-3m6xA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpg DIHYDROOROTASE

(Bacillus
anthracis) 		PF01979
(Amidohydro_1) 		5 GLY A  83
ASP A 359
ALA A 358
ARG A 367
PRO A  53
 None
 1.17A 5zvgB-3mpgA:
undetectable		 5zvgB-3mpgA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		5 ALA A 382
GLY A 539
ASP A 394
ALA A 393
PRO A 587
 None
 1.21A 5zvgB-3n23A:
undetectable		 5zvgB-3n23A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3op1 MACROLIDE-EFFLUX
PROTEIN

(Streptococcus
pneumoniae) 		PF01687
(Flavokinase)
PF06574
(FAD_syn) 		5 ALA A  63
PRO A  66
ALA A 103
PRO A  60
PHE A  98
 None
PEG  A 314 (-3.6A)
None
None
None
 1.22A 5zvgB-3op1A:
undetectable		 5zvgB-3op1A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qxz ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus) 		PF00378
(ECH_1) 		5 ALA A  59
PRO A  21
SER A  26
ALA A 105
ARG A 126
 None
None
None
None
GOL  A 269 ( 4.8A)
 1.35A 5zvgB-3qxzA:
undetectable		 5zvgB-3qxzA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9r PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE

(Mycobacteroides
abscessus) 		PF01259
(SAICAR_synt) 		5 GLY A  -1
SER A   4
ALA A  87
ARG A  86
PRO A 295
 GLY  A  -1 ( 0.0A)
SER  A   4 ( 0.0A)
ALA  A  87 ( 0.0A)
ARG  A  86 ( 0.6A)
PRO  A 295 ( 1.1A)
 1.05A 5zvgB-3r9rA:
undetectable		 5zvgB-3r9rA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rf5 MACROPHAGE MIGRATION
INHIBITORY FACTOR

(Ancylostoma
ceylanicum) 		PF01187
(MIF) 		5 PRO A  10
GLY A  44
LYS A  88
ASP A  85
PRO A  15
 None
 1.26A 5zvgB-3rf5A:
undetectable		 5zvgB-3rf5A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vd8 MALTOSE-BINDING
PERIPLASMIC PROTEIN,
INTERFERON-INDUCIBLE
PROTEIN AIM2

(Escherichia
coli;
Homo sapiens) 		PF02758
(PYRIN)
PF13416
(SBP_bac_8) 		5 ALA A 338
PRO A 334
GLY A  69
ALA A 342
TYR A1092
 None
K  A1209 ( 4.5A)
K  A1209 (-3.6A)
None
None
 1.19A 5zvgB-3vd8A:
undetectable		 5zvgB-3vd8A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrd FLAVOCYTOCHROME C
FLAVIN SUBUNIT

(Thermochromatium
tepidum) 		PF07992
(Pyr_redox_2)
PF09242
(FCSD-flav_bind) 		5 ALA B 315
PRO B 331
GLY B 329
SER B 310
ALA B  17
 None
 1.17A 5zvgB-3vrdB:
2.7		 5zvgB-3vrdB:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4es9 EPF

(Streptococcus
pyogenes) 		no annotation 5 PRO A 133
GLY A  84
ASP A 240
ALA A 124
ARG A 125
 None
 1.31A 5zvgB-4es9A:
undetectable		 5zvgB-4es9A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f6t MOLYBDENUM STORAGE
PROTEIN SUBUNIT
ALPHA

(Azotobacter
vinelandii) 		PF00696
(AA_kinase) 		5 PRO A 154
ALA A  84
ARG A  85
PRO A 166
PHE A  88
 8M0  A 303 (-4.4A)
None
ATP  A 301 (-4.2A)
None
None
 1.28A 5zvgB-4f6tA:
undetectable		 5zvgB-4f6tA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fbq DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1,DNA
REPAIR PROTEIN RAD32
CHIMERIC PROTEIN

(Schizosaccharomyces
pombe) 		PF00149
(Metallophos)
PF04152
(Mre11_DNA_bind) 		5 ALA A1076
LYS A1033
ALA A1080
PRO A1072
PHE A1067
 None
 1.28A 5zvgB-4fbqA:
undetectable		 5zvgB-4fbqA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fnq ALPHA-GALACTOSIDASE
AGAB

(Geobacillus
stearothermophilus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		5 ALA A 587
PRO A 579
SER A 576
ALA A 591
PHE A 717
 None
 1.12A 5zvgB-4fnqA:
undetectable		 5zvgB-4fnqA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		7 PRO A 185
GLY A 186
LYS A 187
SER A 206
ASP A 237
ARG A 239
PRO A 257
 SAM  A 401 (-3.6A)
SAM  A 401 (-3.9A)
SAM  A 401 (-3.5A)
SAM  A 401 (-4.8A)
SAM  A 401 (-3.5A)
None
SAM  A 401 (-4.0A)
 0.44A 5zvgB-4fzvA:
28.6		 5zvgB-4fzvA:
27.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h0m C-PHYCOCYANIN ALPHA
CHAIN
C-PHYCOCYANIN BETA
CHAIN

(Synechococcus
elongatus;
Synechococcus
elongatus) 		PF00502
(Phycobilisome)
PF00502
(Phycobilisome) 		5 ALA A  10
LYS A   1
ALA A  12
ARG B  91
TYR B  92
 None
 1.13A 5zvgB-4h0mA:
undetectable		 5zvgB-4h0mA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3g BETA-GLUCOSIDASE

(Streptomyces
venezuelae) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 ALA A 120
GLY A 612
ASP A 125
ARG A 176
TYR A 769
 None
None
SO4  A 905 (-3.7A)
SO4  A 905 (-4.1A)
None
 1.30A 5zvgB-4i3gA:
undetectable		 5zvgB-4i3gA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ius GCN5-RELATED
N-ACETYLTRANSFERASE

(Kribbella
flavida) 		PF00583
(Acetyltransf_1) 		5 ALA A 207
GLY A 215
ALA A 203
ARG A 231
TYR A 233
 None
None
None
MLI  A 501 (-3.8A)
None
 1.28A 5zvgB-4iusA:
undetectable		 5zvgB-4iusA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jgt 3-MERCAPTOPYRUVATE
SULFURTRANSFERASE

(Homo sapiens) 		PF00581
(Rhodanese) 		5 ALA A 258
PRO A 267
GLY A 265
ALA A 254
ARG A 112
 None
 1.32A 5zvgB-4jgtA:
undetectable		 5zvgB-4jgtA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8d PUTATIVE
UNCHARACTERIZED
PROTEIN

(Labrenzia
aggregata) 		PF04199
(Cyclase) 		5 ALA A 258
PRO A 233
GLY A 236
ALA A 256
ARG A 255
 None
 1.29A 5zvgB-4m8dA:
undetectable		 5zvgB-4m8dA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mbr SERINE-RICH REPEAT
PROTEIN 2

(Streptococcus
agalactiae) 		PF10425
(SdrG_C_C) 		5 GLY A 425
LYS A 418
SER A 419
ASP A 416
ARG A 384
 None
 1.32A 5zvgB-4mbrA:
undetectable		 5zvgB-4mbrA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ord THIOESTERASE
SUPERFAMILY MEMBER 2

(Danio rerio) 		PF03061
(4HBT) 		5 ALA A 115
PRO A  81
GLY A  79
SER A  84
ARG A 134
 None
 1.31A 5zvgB-4ordA:
undetectable		 5zvgB-4ordA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p2b GLUTAMINE
AMINOACYL-TRNA
SYNTHETASE

(Toxoplasma
gondii) 		PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C) 		5 ALA A 228
ASP A  81
ALA A 113
PRO A 223
PHE A 117
 None
 1.21A 5zvgB-4p2bA:
undetectable		 5zvgB-4p2bA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4px1 MALEYLACETOACETATE
ISOMERASE
(GLUTATHIONE
S-TRANSFERASE)

(Methylobacterium
extorquens) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 ALA A  18
PRO A  81
GLY A  79
SER A 162
ARG A  14
 None
 1.33A 5zvgB-4px1A:
undetectable		 5zvgB-4px1A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3r ARGINASE

(Schistosoma
mansoni) 		PF00491
(Arginase) 		5 ALA A 134
GLY A 140
ASP A 262
ALA A 306
PRO A 174
 None
None
MN  A 402 (-2.8A)
None
None
 1.04A 5zvgB-4q3rA:
3.4		 5zvgB-4q3rA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rwe SUGAR-BINDING
TRANSPORT PROTEIN

(Yersinia pestis) 		PF13407
(Peripla_BP_4) 		5 ALA A 225
PRO A 220
GLY A 192
ALA A 229
PHE A 237
 None
 1.34A 5zvgB-4rweA:
undetectable		 5zvgB-4rweA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x4j PUTATIVE OXYGENASE

(Amycolatopsis
orientalis) 		PF01494
(FAD_binding_3) 		5 ALA A 441
PRO A 402
SER A 404
PRO A 443
PHE A 419
 None
None
SO4  A 501 ( 3.8A)
None
None
 1.29A 5zvgB-4x4jA:
2.7		 5zvgB-4x4jA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgh CITRATE SYNTHASE

(Burkholderia
thailandensis) 		PF00285
(Citrate_synt) 		5 ALA A 137
GLY A 266
ASP A 132
ALA A 133
ARG A 130
 SO4  A 505 ( 4.8A)
None
None
None
None
 1.35A 5zvgB-4xghA:
undetectable		 5zvgB-4xghA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yiv APICAL MEMBRANE
ANTIGEN AMA1

(Toxoplasma
gondii) 		PF02430
(AMA-1) 		5 ALA A 195
GLY A 115
ASP A 190
ARG A 193
PRO A 279
 None
 1.19A 5zvgB-4yivA:
undetectable		 5zvgB-4yivA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysw XANTHINE
DEHYDROGENASE/OXIDAS
E

(Rattus
norvegicus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 ALA A1189
GLY A1041
SER A 107
PRO A 576
PHE A 560
 None
 1.28A 5zvgB-4yswA:
undetectable		 5zvgB-4yswA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z3y BENZOYL-COA
REDUCTASE, PUTATIVE

(Geobacter
metallireducens) 		PF01314
(AFOR_C)
PF02730
(AFOR_N) 		5 ALA A 175
GLY A 353
SER A  84
ASP A 195
ARG A 171
 None
MTE  A 703 (-3.6A)
None
None
None
 1.33A 5zvgB-4z3yA:
undetectable		 5zvgB-4z3yA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z3y BENZOYL-COA
REDUCTASE, PUTATIVE

(Geobacter
metallireducens) 		PF01314
(AFOR_C)
PF02730
(AFOR_N) 		5 ALA A 244
PRO A 541
GLY A 247
ASP A 238
PRO A 235
 None
None
SF4  A 701 (-3.6A)
None
None
 1.17A 5zvgB-4z3yA:
undetectable		 5zvgB-4z3yA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8f HUMAN SAFFOLD
VIRUS-3 VP2

(Cardiovirus B) 		PF00073
(Rhv) 		5 ALA C 232
PRO C 236
GLY C 124
ASP C 154
ARG C  81
 None
 1.35A 5zvgB-5a8fC:
undetectable		 5zvgB-5a8fC:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5axk TRNA(HIS)-5'-GUANYLY
LTRANSFERASE (THG1)
LIKE PROTEIN

(Methanosarcina
acetivorans) 		PF04446
(Thg1)
PF14413
(Thg1C) 		5 GLY A  58
SER A  89
ASP A 112
ALA A  20
ARG A 114
 None
 0.97A 5zvgB-5axkA:
undetectable		 5zvgB-5axkA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bq7 FAB 5F-10-HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 ALA A 141
GLY A 167
LYS A 134
SER A 135
PRO A 131
 None
 1.32A 5zvgB-5bq7A:
undetectable		 5zvgB-5bq7A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ere EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Desulfohalobium
retbaense) 		PF13458
(Peripla_BP_6) 		5 ALA A 382
GLY A 389
SER A 485
ASP A 375
PRO A 472
 None
None
CYT  A 602 (-3.5A)
None
None
 1.16A 5zvgB-5ereA:
2.2		 5zvgB-5ereA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fx8 ZONADHESIN

(Komagataella
phaffii) 		no annotation 5 ALA U 217
PRO U 247
ASP U 187
PRO U 230
PHE U 228
 None
 1.06A 5zvgB-5fx8U:
undetectable		 5zvgB-5fx8U:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fyk VRC01

(Homo sapiens) 		PF07686
(V-set) 		5 ALA U  88
PRO U 108
GLY U 106
ASP U  85
PRO U  41
 None
 1.30A 5zvgB-5fykU:
undetectable		 5zvgB-5fykU:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy7 TATA-BOX-BINDING
PROTEIN

(Homo sapiens) 		PF00352
(TBP) 		5 ALA P 238
PRO P 247
GLY P 245
ALA P 234
ARG P 231
 None
 1.20A 5zvgB-5iy7P:
undetectable		 5zvgB-5iy7P:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5joz NON-REDUCING END
ALPHA-L-ARABINOFURAN
OSIDASE BOGH43B

(Bacteroides
ovatus) 		PF04616
(Glyco_hydro_43) 		5 PRO A 197
GLY A 194
ASP A 262
ALA A 261
TYR A 203
 None
 1.05A 5zvgB-5jozA:
undetectable		 5zvgB-5jozA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jta NEUTRAL TREHALASE

(Saccharomyces
cerevisiae) 		no annotation 5 ALA A 488
PRO A 403
SER A 412
ASP A 557
ARG A 482
 None
 1.13A 5zvgB-5jtaA:
undetectable		 5zvgB-5jtaA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mn5 CELL DIVISION
PROTEIN FTSZ

(Staphylococcus
aureus) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 ALA A 275
GLY A 267
ASP A 280
ALA A 279
PHE A 294
 None
 1.23A 5zvgB-5mn5A:
3.2		 5zvgB-5mn5A:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1) 		no annotation 5 ALA A 113
GLY A 398
ASP A 254
ALA A 250
PRO A 482
 None
 1.17A 5zvgB-5nd1A:
undetectable		 5zvgB-5nd1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ndf POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 2

(Homo sapiens) 		no annotation 5 ALA A 151
GLY A 358
ALA A 148
ARG A 149
TYR A  86
 None
 1.13A 5zvgB-5ndfA:
undetectable		 5zvgB-5ndfA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tjf ALLOPHYCOCYANIN
ALPHA SUBUNIT
ALLOPHYCOCYANIN BETA
SUBUNIT

(Gracilaria
chilensis;
Gracilaria
chilensis) 		PF00502
(Phycobilisome)
PF00502
(Phycobilisome) 		5 ALA B  98
GLY B  34
SER A   7
ASP A  12
ARG B 107
 None
NA  B 208 ( 4.4A)
None
CL  B 216 ( 4.7A)
CL  B 216 ( 3.1A)
 1.30A 5zvgB-5tjfB:
undetectable		 5zvgB-5tjfB:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uv2 (+)-LIMONENE
SYNTHASE

(Citrus sinensis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		5 ALA A 205
GLY A 176
LYS A 171
SER A 210
ALA A 191
 None
 1.33A 5zvgB-5uv2A:
undetectable		 5zvgB-5uv2A:
21.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		5 PRO A 245
GLY A 247
LYS A 248
ASP A 293
PRO A 325
 C  C  72 ( 4.7A)
None
C  C  72 ( 3.1A)
None
None
 0.44A 5zvgB-5wwtA:
42.6		 5zvgB-5wwtA:
33.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		5 PRO A 245
GLY A 247
LYS A 248
LYS A 267
PRO A 325
 C  C  72 ( 4.7A)
None
C  C  72 ( 3.1A)
G  C   3 ( 3.5A)
None
 0.76A 5zvgB-5wwtA:
42.6		 5zvgB-5wwtA:
33.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8h SHORT-CHAIN
DEHYDROGENASE
REDUCTASE

(Chryseobacterium
sp. CA49) 		no annotation 5 ALA A  23
GLY A  30
SER A  58
ASP A  37
ALA A  14
 None
 1.27A 5zvgB-5x8hA:
7.0		 5zvgB-5x8hA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8j THYMIDYLATE KINASE

(Thermus
thermophilus) 		no annotation 5 ALA A  24
PRO A  33
GLY A  31
ASP A  90
ALA A  20
 None
None
None
FMT  A 201 ( 4.6A)
None
 1.03A 5zvgB-5x8jA:
undetectable		 5zvgB-5x8jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zct -

(-) 		no annotation 5 ALA A   4
GLY A  10
LYS A   2
ASP A  59
ALA A  60
 None
 1.33A 5zvgB-5zctA:
2.3		 5zvgB-5zctA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c43 GAMMA-AMINOBUTYRALDE
HYDE DEHYDROGENASE

(Salmonella
enterica) 		no annotation 6 ALA A 164
PRO A 138
GLY A  56
ALA A 114
PRO A 161
PHE A 111
 None
 1.34A 5zvgB-6c43A:
undetectable		 5zvgB-6c43A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cwr -

(-) 		no annotation 5 ALA A  41
GLY A  73
SER A  45
ASP A  36
ALA A  37
 None
 1.33A 5zvgB-6cwrA:
undetectable		 5zvgB-6cwrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ejf -

(-) 		no annotation 5 ALA G 404
PRO G 409
LYS G 451
ASP G 398
PRO G 402
 None
 1.34A 5zvgB-6ejfG:
undetectable		 5zvgB-6ejfG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gc6 50S RIBOSOMAL
PROTEIN L2

(Escherichia
coli) 		no annotation 5 PRO C 125
GLY C 108
ASP C  65
ARG C 101
TYR C  95
 None
 1.15A 5zvgB-6gc6C:
undetectable		 5zvgB-6gc6C:
undetectable