SIMILAR PATTERNS OF AMINO ACIDS FOR 5ZVG_B_SAMB401

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a3g BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE

(Escherichia
coli) 		PF01063
(Aminotran_4) 		5 ALA A 123
PRO A  98
GLY A  38
ASP A   6
ALA A   5
 None
 0.95A 5zvgB-1a3gA:
undetectable		 5zvgB-1a3gA:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5z L-LACTATE
DEHYDROGENASE

(Thermotoga
maritima) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ALA A 251
GLY A  30
SER A 163
ASP A 256
ALA A 255
 None
NAD  A 352 (-2.6A)
None
None
None
 1.20A 5zvgB-1a5zA:
6.9		 5zvgB-1a5zA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bdb CIS-BIPHENYL-2,3-DIH
YDRODIOL-2,3-DEHYDRO
GENASE

(Pseudomonas sp.) 		PF00106
(adh_short) 		5 ALA A  87
LYS A  37
SER A  38
ASP A  59
ARG A  61
 NAD  A 300 ( 3.8A)
NAD  A 300 (-4.4A)
None
NAD  A 300 (-3.2A)
NAD  A 300 ( 4.6A)
 1.16A 5zvgB-1bdbA:
6.5		 5zvgB-1bdbA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bdy PROTEIN KINASE C

(Rattus
norvegicus) 		no annotation 5 PRO A  53
ASP A  79
ALA A  76
ARG A  75
PRO A  26
 None
 1.30A 5zvgB-1bdyA:
undetectable		 5zvgB-1bdyA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)

(Geobacillus
stearothermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		5 ALA A 193
PRO A 105
GLY A  76
LYS A 108
ALA A 191
 None
None
None
PO4  A2001 ( 2.8A)
None
 1.10A 5zvgB-1brwA:
undetectable		 5zvgB-1brwA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bw0 PROTEIN (TYROSINE
AMINOTRANSFERASE)

(Trypanosoma
cruzi) 		PF00155
(Aminotran_1_2) 		5 PRO A 340
GLY A 342
SER A 348
ALA A 384
PRO A 159
 None
 1.30A 5zvgB-1bw0A:
undetectable		 5zvgB-1bw0A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d0q DNA PRIMASE

(Geobacillus
stearothermophilus) 		PF01807
(zf-CHC2) 		5 PRO A  48
SER A  51
ALA A  66
PRO A  41
PHE A  42
 None
 1.33A 5zvgB-1d0qA:
undetectable		 5zvgB-1d0qA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dp2 RHODANESE

(Bos taurus) 		PF00581
(Rhodanese) 		5 ALA A 257
PRO A 266
GLY A 264
ALA A 253
ARG A 110
 None
 1.28A 5zvgB-1dp2A:
undetectable		 5zvgB-1dp2A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1izc MACROPHOMATE
SYNTHASE
INTERMOLECULAR
DIELS-ALDERASE

(Macrophoma
commelinae) 		PF03328
(HpcH_HpaI) 		5 ALA A  84
PRO A  51
GLY A  74
LYS A  57
ALA A  88
 None
 1.29A 5zvgB-1izcA:
undetectable		 5zvgB-1izcA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1khd ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Pectobacterium
carotovorum) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		5 ALA A 197
PRO A  78
ALA A 118
PRO A  82
TYR A  84
 None
 1.06A 5zvgB-1khdA:
undetectable		 5zvgB-1khdA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogp SULFITE OXIDASE

(Arabidopsis
thaliana) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		5 ALA A 353
GLY A 307
SER A 380
ALA A 355
TYR A 289
 None
 1.24A 5zvgB-1ogpA:
undetectable		 5zvgB-1ogpA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qs0 2-OXOISOVALERATE
DEHYDROGENASE
BETA-SUBUNIT

(Pseudomonas
putida) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 ALA B  11
SER B 200
ASP B 155
ALA B 156
TYR B 207
 None
 1.29A 5zvgB-1qs0B:
undetectable		 5zvgB-1qs0B:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rfy TRANSCRIPTIONAL
REPRESSOR TRAM

(Agrobacterium
tumefaciens) 		PF09228
(Prok-TraM) 		5 LYS A  10
ASP A  35
ALA A  36
ARG A  38
PRO A  97
 None
 1.30A 5zvgB-1rfyA:
undetectable		 5zvgB-1rfyA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6r CREATINE KINASE, M
CHAIN

(Oryctolagus
cuniculus) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		5 LYS A 176
SER A 177
ASP A 212
ALA A 213
ARG A 151
 None
 1.29A 5zvgB-1u6rA:
undetectable		 5zvgB-1u6rA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uqw PUTATIVE BINDING
PROTEIN YLIB

(Escherichia
coli) 		PF00496
(SBP_bac_5) 		5 GLY A  38
SER A 389
ASP A 394
ALA A 130
PHE A 128
 None
 1.08A 5zvgB-1uqwA:
undetectable		 5zvgB-1uqwA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4v UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Thermus
thermophilus) 		PF02350
(Epimerase_2) 		5 ALA A  18
GLY A  42
ALA A  22
TYR A 265
PHE A  55
 None
 1.21A 5zvgB-1v4vA:
undetectable		 5zvgB-1v4vA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve3 HYPOTHETICAL PROTEIN
PH0226

(Pyrococcus
horikoshii) 		PF13649
(Methyltransf_25) 		7 ALA A  46
GLY A  51
SER A  69
ASP A  93
ALA A  94
ARG A  95
PHE A 116
 SAM  A 302 (-3.4A)
None
SAM  A 302 (-4.7A)
SAM  A 302 (-3.4A)
SAM  A 302 (-3.3A)
None
SAM  A 302 (-4.4A)
 1.20A 5zvgB-1ve3A:
13.3		 5zvgB-1ve3A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wel RNA-BINDING PROTEIN
12

(Homo sapiens) 		PF00076
(RRM_1) 		5 ALA A 463
PRO A 466
GLY A 468
TYR A 433
PHE A 475
 None
 1.35A 5zvgB-1welA:
undetectable		 5zvgB-1welA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wnb PUTATIVE BETAINE
ALDEHYDE
DEHYDROGENASE

(Escherichia
coli) 		PF00171
(Aldedh) 		6 ALA A 164
PRO A 138
GLY A  56
ALA A 114
PRO A 161
PHE A 111
 None
 1.34A 5zvgB-1wnbA:
undetectable		 5zvgB-1wnbA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wpx CARBOXYPEPTIDASE Y
INHIBITOR

(Saccharomyces
cerevisiae) 		PF01161
(PBP) 		5 ALA B 716
PRO B 655
GLY B 657
ALA B 557
PHE B 714
 None
 1.33A 5zvgB-1wpxB:
undetectable		 5zvgB-1wpxB:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfk FORMIMIDOYLGLUTAMASE

(Vibrio cholerae) 		PF00491
(Arginase) 		5 ALA A 130
GLY A 136
ASP A 254
ALA A 299
PRO A 179
 None
 1.28A 5zvgB-1xfkA:
undetectable		 5zvgB-1xfkA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkw FE(III)-PYOCHELIN
RECEPTOR

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 ALA A 340
GLY A 346
ARG A 655
PRO A 700
TYR A 654
 None
 1.17A 5zvgB-1xkwA:
undetectable		 5zvgB-1xkwA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cex PROTEIN HI0146

(Haemophilus
influenzae) 		PF03480
(DctP) 		5 ALA A  82
GLY A 125
ALA A  79
PRO A  84
TYR A 282
 None
 1.19A 5zvgB-2cexA:
undetectable		 5zvgB-2cexA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2col BIFUNCTIONAL
HEMOLYSIN-ADENYLATE
CYCLASE

(Bordetella
pertussis) 		PF03497
(Anthrax_toxA) 		5 GLY A 143
LYS A  65
SER A  66
ASP A  99
ALA A  96
 None
POP  A 893 (-2.4A)
None
None
None
 0.96A 5zvgB-2colA:
undetectable		 5zvgB-2colA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2deo 441AA LONG
HYPOTHETICAL NFED
PROTEIN

(Pyrococcus
horikoshii) 		PF00574
(CLP_protease) 		5 ALA A  93
PRO A  63
GLY A  31
LYS A  30
ALA A 112
 None
 1.34A 5zvgB-2deoA:
undetectable		 5zvgB-2deoA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE

(Escherichia
coli) 		PF01557
(FAA_hydrolase) 		5 GLY A 170
SER A 263
ASP A 255
ALA A 190
PRO A 136
 None
 1.32A 5zvgB-2eb5A:
undetectable		 5zvgB-2eb5A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ffu POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 2

(Homo sapiens) 		PF00535
(Glycos_transf_2)
PF00652
(Ricin_B_lectin) 		5 ALA A 151
GLY A 358
ALA A 148
ARG A 149
TYR A  86
 None
 1.18A 5zvgB-2ffuA:
undetectable		 5zvgB-2ffuA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fhp METHYLASE, PUTATIVE

(Enterococcus
faecalis) 		PF03602
(Cons_hypoth95) 		5 GLY A  54
LYS A  72
ASP A  99
ALA A 100
PRO A 122
 None
 1.06A 5zvgB-2fhpA:
12.8		 5zvgB-2fhpA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli) 		PF01189
(Methyltr_RsmB-F)
PF13636
(Methyltranf_PUA)
PF17125
(Methyltr_RsmF_N) 		5 ALA A 125
PRO A 128
SER A 151
ARG A 178
PRO A 196
 None
 0.90A 5zvgB-2frxA:
34.6		 5zvgB-2frxA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli) 		PF01189
(Methyltr_RsmB-F)
PF13636
(Methyltranf_PUA)
PF17125
(Methyltr_RsmF_N) 		5 PRO A 128
LYS A 131
SER A 151
ARG A 178
PRO A 196
 None
 1.06A 5zvgB-2frxA:
34.6		 5zvgB-2frxA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hcz BETA-EXPANSIN 1A

(Zea mays) 		PF01357
(Pollen_allerg_1)
PF03330
(DPBB_1) 		5 ALA X 169
GLY X 145
ASP X 173
ARG X 137
TYR X  15
 None
 1.29A 5zvgB-2hczX:
undetectable		 5zvgB-2hczX:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ibu ACETYL-COA
ACETYLTRANSFERASE

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 ALA A 355
GLY A 415
SER A 411
ALA A 380
TYR A 214
 COA  A6001 (-3.6A)
CSO  A 126 ( 4.2A)
None
None
None
 1.15A 5zvgB-2ibuA:
undetectable		 5zvgB-2ibuA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogx MOLYBDENUM STORAGE
PROTEIN SUBUNIT
ALPHA

(Azotobacter
vinelandii) 		PF00696
(AA_kinase) 		5 PRO A 154
ALA A  84
ARG A  85
PRO A 166
PHE A  88
 None
None
ATP  A 281 (-4.2A)
None
None
 1.28A 5zvgB-2ogxA:
undetectable		 5zvgB-2ogxA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		5 ALA A 178
GLY A 183
ASP A 243
ARG A 265
PRO A 261
 SAM  A 500 (-3.4A)
SAM  A 500 (-3.2A)
SAM  A 500 (-3.3A)
SAM  A 500 ( 4.6A)
SAM  A 500 (-4.1A)
 1.10A 5zvgB-2okcA:
10.3		 5zvgB-2okcA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		5 ALA A 178
GLY A 183
ASP A 243
PRO A 261
PHE A 288
 SAM  A 500 (-3.4A)
SAM  A 500 (-3.2A)
SAM  A 500 (-3.3A)
SAM  A 500 (-4.1A)
SAM  A 500 (-4.8A)
 0.78A 5zvgB-2okcA:
10.3		 5zvgB-2okcA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qcm URIDINE
5'-MONOPHOSPHATE
SYNTHASE (UMP
SYNTHASE)

(Homo sapiens) 		PF00215
(OMPdecase) 		5 ALA A 342
GLY A 399
SER A 348
ASP A 317
ALA A 316
 None
 1.35A 5zvgB-2qcmA:
undetectable		 5zvgB-2qcmA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rdy BH0842 PROTEIN

(Bacillus
halodurans) 		PF14498
(Glyco_hyd_65N_2) 		5 SER A 367
ASP A 425
ALA A 424
PRO A 350
PHE A 397
 None
 1.20A 5zvgB-2rdyA:
undetectable		 5zvgB-2rdyA:
20.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN

(Pyrococcus
horikoshii) 		PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N) 		8 ALA A 267
PRO A 270
GLY A 272
LYS A 273
ASP A 318
ALA A 319
ARG A 320
PRO A 339
 SFG  A5748 (-3.4A)
SFG  A5748 (-3.6A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.3A)
SFG  A5748 (-3.7A)
SFG  A5748 (-3.4A)
SFG  A5748 (-4.5A)
SFG  A5748 (-4.0A)
 0.32A 5zvgB-2yxlA:
38.5		 5zvgB-2yxlA:
32.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026

(Methanocaldococcus
jannaschii) 		PF01189
(Methyltr_RsmB-F) 		7 PRO A  94
GLY A  96
LYS A  97
SER A 117
ASP A 142
ARG A 144
PRO A 165
 SFG  A 500 (-3.9A)
SFG  A 500 (-3.5A)
SFG  A 500 (-2.8A)
None
SFG  A 500 (-4.0A)
None
SFG  A 500 (-3.9A)
 0.65A 5zvgB-3a4tA:
31.7		 5zvgB-3a4tA:
32.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3acz METHIONINE
GAMMA-LYASE

(Entamoeba
histolytica) 		PF01053
(Cys_Met_Meta_PP) 		5 ALA A 181
GLY A 304
SER A 202
ALA A 199
TYR A 149
 None
None
LLP  A 205 ( 2.8A)
None
None
 1.10A 5zvgB-3aczA:
3.9		 5zvgB-3aczA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3u 4-HYDROXYBUTYRATE
COA-TRANSFERASE

(Porphyromonas
gingivalis) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		5 GLY A 337
LYS A 101
SER A 138
ALA A 144
PHE A 110
 None
 1.27A 5zvgB-3d3uA:
2.7		 5zvgB-3d3uA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edl KINESIN13 MOTOR
DOMAIN

(Drosophila
melanogaster) 		PF00225
(Kinesin) 		5 ALA D 377
GLY D 165
ASP D 397
ALA D 396
PHE D 125
 None
ANP  D 500 ( 3.3A)
None
None
None
 1.33A 5zvgB-3edlD:
undetectable		 5zvgB-3edlD:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2u KINESIN-LIKE PROTEIN
KLP10A

(Drosophila
melanogaster) 		PF00225
(Kinesin) 		5 ALA K 585
GLY K 371
ASP K 605
ALA K 604
PHE K 331
 None
 1.35A 5zvgB-3j2uK:
undetectable		 5zvgB-3j2uK:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2u KINESIN-LIKE PROTEIN
KLP10A

(Drosophila
melanogaster) 		PF00225
(Kinesin) 		5 ALA K 585
GLY K 373
ASP K 605
ALA K 604
PHE K 331
 None
 1.26A 5zvgB-3j2uK:
undetectable		 5zvgB-3j2uK:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF2
PRE-MRNA-SPLICING
FACTOR CWF5

(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe) 		PF00076
(RRM_1)
PF16131
(Torus)
PF08082
(PRO8NT)
PF08083
(PROCN)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		5 ALA a  98
GLY a 106
ALA Y 266
ARG Y 265
TYR Y 174
 None
 1.22A 5zvgB-3jb9a:
undetectable		 5zvgB-3jb9a:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khp MAOC FAMILY PROTEIN

(Mycobacterium
tuberculosis) 		PF01575
(MaoC_dehydratas)
PF13452
(MaoC_dehydrat_N) 		5 ALA A 284
GLY A 260
ALA A 238
ARG A 239
PRO A 158
 None
 1.08A 5zvgB-3khpA:
undetectable		 5zvgB-3khpA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6x RRNA METHYLASE

(Thermus
thermophilus) 		PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N)
PF17126
(RsmF_methylt_CI) 		5 ALA A 109
PRO A 112
GLY A 114
LYS A 115
PRO A 179
 None
 0.43A 5zvgB-3m6xA:
35.5		 5zvgB-3m6xA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpg DIHYDROOROTASE

(Bacillus
anthracis) 		PF01979
(Amidohydro_1) 		5 GLY A  83
ASP A 359
ALA A 358
ARG A 367
PRO A  53
 None
 1.17A 5zvgB-3mpgA:
undetectable		 5zvgB-3mpgA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		5 ALA A 382
GLY A 539
ASP A 394
ALA A 393
PRO A 587
 None
 1.21A 5zvgB-3n23A:
undetectable		 5zvgB-3n23A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3op1 MACROLIDE-EFFLUX
PROTEIN

(Streptococcus
pneumoniae) 		PF01687
(Flavokinase)
PF06574
(FAD_syn) 		5 ALA A  63
PRO A  66
ALA A 103
PRO A  60
PHE A  98
 None
PEG  A 314 (-3.6A)
None
None
None
 1.22A 5zvgB-3op1A:
undetectable		 5zvgB-3op1A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qxz ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus) 		PF00378
(ECH_1) 		5 ALA A  59
PRO A  21
SER A  26
ALA A 105
ARG A 126
 None
None
None
None
GOL  A 269 ( 4.8A)
 1.35A 5zvgB-3qxzA:
undetectable		 5zvgB-3qxzA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9r PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE

(Mycobacteroides
abscessus) 		PF01259
(SAICAR_synt) 		5 GLY A  -1
SER A   4
ALA A  87
ARG A  86
PRO A 295
 GLY  A  -1 ( 0.0A)
SER  A   4 ( 0.0A)
ALA  A  87 ( 0.0A)
ARG  A  86 ( 0.6A)
PRO  A 295 ( 1.1A)
 1.05A 5zvgB-3r9rA:
undetectable		 5zvgB-3r9rA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rf5 MACROPHAGE MIGRATION
INHIBITORY FACTOR

(Ancylostoma
ceylanicum) 		PF01187
(MIF) 		5 PRO A  10
GLY A  44
LYS A  88
ASP A  85
PRO A  15
 None
 1.26A 5zvgB-3rf5A:
undetectable		 5zvgB-3rf5A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vd8 MALTOSE-BINDING
PERIPLASMIC PROTEIN,
INTERFERON-INDUCIBLE
PROTEIN AIM2

(Escherichia
coli;
Homo sapiens) 		PF02758
(PYRIN)
PF13416
(SBP_bac_8) 		5 ALA A 338
PRO A 334
GLY A  69
ALA A 342
TYR A1092
 None
K  A1209 ( 4.5A)
K  A1209 (-3.6A)
None
None
 1.19A 5zvgB-3vd8A:
undetectable		 5zvgB-3vd8A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrd FLAVOCYTOCHROME C
FLAVIN SUBUNIT

(Thermochromatium
tepidum) 		PF07992
(Pyr_redox_2)
PF09242
(FCSD-flav_bind) 		5 ALA B 315
PRO B 331
GLY B 329
SER B 310
ALA B  17
 None
 1.17A 5zvgB-3vrdB:
2.7		 5zvgB-3vrdB:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4es9 EPF

(Streptococcus
pyogenes) 		no annotation 5 PRO A 133
GLY A  84
ASP A 240
ALA A 124
ARG A 125
 None
 1.31A 5zvgB-4es9A:
undetectable		 5zvgB-4es9A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f6t MOLYBDENUM STORAGE
PROTEIN SUBUNIT
ALPHA

(Azotobacter
vinelandii) 		PF00696
(AA_kinase) 		5 PRO A 154
ALA A  84
ARG A  85
PRO A 166
PHE A  88
 8M0  A 303 (-4.4A)
None
ATP  A 301 (-4.2A)
None
None
 1.28A 5zvgB-4f6tA:
undetectable		 5zvgB-4f6tA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fbq DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1,DNA
REPAIR PROTEIN RAD32
CHIMERIC PROTEIN

(Schizosaccharomyces
pombe) 		PF00149
(Metallophos)
PF04152
(Mre11_DNA_bind) 		5 ALA A1076
LYS A1033
ALA A1080
PRO A1072
PHE A1067
 None
 1.28A 5zvgB-4fbqA:
undetectable		 5zvgB-4fbqA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fnq ALPHA-GALACTOSIDASE
AGAB

(Geobacillus
stearothermophilus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		5 ALA A 587
PRO A 579
SER A 576
ALA A 591
PHE A 717
 None
 1.12A 5zvgB-4fnqA:
undetectable		 5zvgB-4fnqA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		7 PRO A 185
GLY A 186
LYS A 187
SER A 206
ASP A 237
ARG A 239
PRO A 257
 SAM  A 401 (-3.6A)
SAM  A 401 (-3.9A)
SAM  A 401 (-3.5A)
SAM  A 401 (-4.8A)
SAM  A 401 (-3.5A)
None
SAM  A 401 (-4.0A)
 0.44A 5zvgB-4fzvA:
28.6		 5zvgB-4fzvA:
27.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h0m C-PHYCOCYANIN ALPHA
CHAIN
C-PHYCOCYANIN BETA
CHAIN

(Synechococcus
elongatus;
Synechococcus
elongatus) 		PF00502
(Phycobilisome)
PF00502
(Phycobilisome) 		5 ALA A  10
LYS A   1
ALA A  12
ARG B  91
TYR B  92
 None
 1.13A 5zvgB-4h0mA:
undetectable		 5zvgB-4h0mA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3g BETA-GLUCOSIDASE

(Streptomyces
venezuelae) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 ALA A 120
GLY A 612
ASP A 125
ARG A 176
TYR A 769
 None
None
SO4  A 905 (-3.7A)
SO4  A 905 (-4.1A)
None
 1.30A 5zvgB-4i3gA:
undetectable		 5zvgB-4i3gA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ius GCN5-RELATED
N-ACETYLTRANSFERASE

(Kribbella
flavida) 		PF00583
(Acetyltransf_1) 		5 ALA A 207
GLY A 215
ALA A 203
ARG A 231
TYR A 233
 None
None
None
MLI  A 501 (-3.8A)
None
 1.28A 5zvgB-4iusA:
undetectable		 5zvgB-4iusA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jgt 3-MERCAPTOPYRUVATE
SULFURTRANSFERASE

(Homo sapiens) 		PF00581
(Rhodanese) 		5 ALA A 258
PRO A 267
GLY A 265
ALA A 254
ARG A 112
 None
 1.32A 5zvgB-4jgtA:
undetectable		 5zvgB-4jgtA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8d PUTATIVE
UNCHARACTERIZED
PROTEIN

(Labrenzia
aggregata) 		PF04199
(Cyclase) 		5 ALA A 258
PRO A 233
GLY A 236
ALA A 256
ARG A 255
 None
 1.29A 5zvgB-4m8dA:
undetectable		 5zvgB-4m8dA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mbr SERINE-RICH REPEAT
PROTEIN 2

(Streptococcus
agalactiae) 		PF10425
(SdrG_C_C) 		5 GLY A 425
LYS A 418
SER A 419
ASP A 416
ARG A 384
 None
 1.32A 5zvgB-4mbrA:
undetectable		 5zvgB-4mbrA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ord THIOESTERASE
SUPERFAMILY MEMBER 2

(Danio rerio) 		PF03061
(4HBT) 		5 ALA A 115
PRO A  81
GLY A  79
SER A  84
ARG A 134
 None
 1.31A 5zvgB-4ordA:
undetectable		 5zvgB-4ordA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p2b GLUTAMINE
AMINOACYL-TRNA
SYNTHETASE

(Toxoplasma
gondii) 		PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C) 		5 ALA A 228
ASP A  81
ALA A 113
PRO A 223
PHE A 117
 None
 1.21A 5zvgB-4p2bA:
undetectable		 5zvgB-4p2bA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4px1 MALEYLACETOACETATE
ISOMERASE
(GLUTATHIONE
S-TRANSFERASE)

(Methylobacterium
extorquens) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 ALA A  18
PRO A  81
GLY A  79
SER A 162
ARG A  14
 None
 1.33A 5zvgB-4px1A:
undetectable		 5zvgB-4px1A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3r ARGINASE

(Schistosoma
mansoni) 		PF00491
(Arginase) 		5 ALA A 134
GLY A 140
ASP A 262
ALA A 306
PRO A 174
 None
None
MN  A 402 (-2.8A)
None
None
 1.04A 5zvgB-4q3rA:
3.4		 5zvgB-4q3rA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rwe SUGAR-BINDING
TRANSPORT PROTEIN

(Yersinia pestis) 		PF13407
(Peripla_BP_4) 		5 ALA A 225
PRO A 220
GLY A 192
ALA A 229
PHE A 237
 None
 1.34A 5zvgB-4rweA:
undetectable		 5zvgB-4rweA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x4j PUTATIVE OXYGENASE

(Amycolatopsis
orientalis) 		PF01494
(FAD_binding_3) 		5 ALA A 441
PRO A 402
SER A 404
PRO A 443
PHE A 419
 None
None
SO4  A 501 ( 3.8A)
None
None
 1.29A 5zvgB-4x4jA:
2.7		 5zvgB-4x4jA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgh CITRATE SYNTHASE

(Burkholderia
thailandensis) 		PF00285
(Citrate_synt) 		5 ALA A 137
GLY A 266
ASP A 132
ALA A 133
ARG A 130
 SO4  A 505 ( 4.8A)
None
None
None
None
 1.35A 5zvgB-4xghA:
undetectable		 5zvgB-4xghA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yiv APICAL MEMBRANE
ANTIGEN AMA1

(Toxoplasma
gondii) 		PF02430
(AMA-1) 		5 ALA A 195
GLY A 115
ASP A 190
ARG A 193
PRO A 279
 None
 1.19A 5zvgB-4yivA:
undetectable		 5zvgB-4yivA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysw XANTHINE
DEHYDROGENASE/OXIDAS
E

(Rattus
norvegicus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 ALA A1189
GLY A1041
SER A 107
PRO A 576
PHE A 560
 None
 1.28A 5zvgB-4yswA:
undetectable		 5zvgB-4yswA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z3y BENZOYL-COA
REDUCTASE, PUTATIVE

(Geobacter
metallireducens) 		PF01314
(AFOR_C)
PF02730
(AFOR_N) 		5 ALA A 175
GLY A 353
SER A  84
ASP A 195
ARG A 171
 None
MTE  A 703 (-3.6A)
None
None
None
 1.33A 5zvgB-4z3yA:
undetectable		 5zvgB-4z3yA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z3y BENZOYL-COA
REDUCTASE, PUTATIVE

(Geobacter
metallireducens) 		PF01314
(AFOR_C)
PF02730
(AFOR_N) 		5 ALA A 244
PRO A 541
GLY A 247
ASP A 238
PRO A 235
 None
None
SF4  A 701 (-3.6A)
None
None
 1.17A 5zvgB-4z3yA:
undetectable		 5zvgB-4z3yA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8f HUMAN SAFFOLD
VIRUS-3 VP2

(Cardiovirus B) 		PF00073
(Rhv) 		5 ALA C 232
PRO C 236
GLY C 124
ASP C 154
ARG C  81
 None
 1.35A 5zvgB-5a8fC:
undetectable		 5zvgB-5a8fC:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5axk TRNA(HIS)-5'-GUANYLY
LTRANSFERASE (THG1)
LIKE PROTEIN

(Methanosarcina
acetivorans) 		PF04446
(Thg1)
PF14413
(Thg1C) 		5 GLY A  58
SER A  89
ASP A 112
ALA A  20
ARG A 114
 None
 0.97A 5zvgB-5axkA:
undetectable		 5zvgB-5axkA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bq7 FAB 5F-10-HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 ALA A 141
GLY A 167
LYS A 134
SER A 135
PRO A 131
 None
 1.32A 5zvgB-5bq7A:
undetectable		 5zvgB-5bq7A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ere EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Desulfohalobium
retbaense) 		PF13458
(Peripla_BP_6) 		5 ALA A 382
GLY A 389
SER A 485
ASP A 375
PRO A 472
 None
None
CYT  A 602 (-3.5A)
None
None
 1.16A 5zvgB-5ereA:
2.2		 5zvgB-5ereA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fx8 ZONADHESIN

(Komagataella
phaffii) 		no annotation 5 ALA U 217
PRO U 247
ASP U 187
PRO U 230
PHE U 228
 None
 1.06A 5zvgB-5fx8U:
undetectable		 5zvgB-5fx8U:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fyk VRC01

(Homo sapiens) 		PF07686
(V-set) 		5 ALA U  88
PRO U 108
GLY U 106
ASP U  85
PRO U  41
 None
 1.30A 5zvgB-5fykU:
undetectable		 5zvgB-5fykU:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy7 TATA-BOX-BINDING
PROTEIN

(Homo sapiens) 		PF00352
(TBP) 		5 ALA P 238
PRO P 247
GLY P 245
ALA P 234
ARG P 231
 None
 1.20A 5zvgB-5iy7P:
undetectable		 5zvgB-5iy7P:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5joz NON-REDUCING END
ALPHA-L-ARABINOFURAN
OSIDASE BOGH43B

(Bacteroides
ovatus) 		PF04616
(Glyco_hydro_43) 		5 PRO A 197
GLY A 194
ASP A 262
ALA A 261
TYR A 203
 None
 1.05A 5zvgB-5jozA:
undetectable		 5zvgB-5jozA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jta NEUTRAL TREHALASE

(Saccharomyces
cerevisiae) 		no annotation 5 ALA A 488
PRO A 403
SER A 412
ASP A 557
ARG A 482
 None
 1.13A 5zvgB-5jtaA:
undetectable		 5zvgB-5jtaA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mn5 CELL DIVISION
PROTEIN FTSZ

(Staphylococcus
aureus) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 ALA A 275
GLY A 267
ASP A 280
ALA A 279
PHE A 294
 None
 1.23A 5zvgB-5mn5A:
3.2		 5zvgB-5mn5A:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1) 		no annotation 5 ALA A 113
GLY A 398
ASP A 254
ALA A 250
PRO A 482
 None
 1.17A 5zvgB-5nd1A:
undetectable		 5zvgB-5nd1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ndf POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 2

(Homo sapiens) 		no annotation 5 ALA A 151
GLY A 358
ALA A 148
ARG A 149
TYR A  86
 None
 1.13A 5zvgB-5ndfA:
undetectable		 5zvgB-5ndfA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tjf ALLOPHYCOCYANIN
ALPHA SUBUNIT
ALLOPHYCOCYANIN BETA
SUBUNIT

(Gracilaria
chilensis;
Gracilaria
chilensis) 		PF00502
(Phycobilisome)
PF00502
(Phycobilisome) 		5 ALA B  98
GLY B  34
SER A   7
ASP A  12
ARG B 107
 None
NA  B 208 ( 4.4A)
None
CL  B 216 ( 4.7A)
CL  B 216 ( 3.1A)
 1.30A 5zvgB-5tjfB:
undetectable		 5zvgB-5tjfB:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uv2 (+)-LIMONENE
SYNTHASE

(Citrus sinensis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		5 ALA A 205
GLY A 176
LYS A 171
SER A 210
ALA A 191
 None
 1.33A 5zvgB-5uv2A:
undetectable		 5zvgB-5uv2A:
21.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		5 PRO A 245
GLY A 247
LYS A 248
ASP A 293
PRO A 325
 C  C  72 ( 4.7A)
None
C  C  72 ( 3.1A)
None
None
 0.44A 5zvgB-5wwtA:
42.6		 5zvgB-5wwtA:
33.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		5 PRO A 245
GLY A 247
LYS A 248
LYS A 267
PRO A 325
 C  C  72 ( 4.7A)
None
C  C  72 ( 3.1A)
G  C   3 ( 3.5A)
None
 0.76A 5zvgB-5wwtA:
42.6		 5zvgB-5wwtA:
33.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8h SHORT-CHAIN
DEHYDROGENASE
REDUCTASE

(Chryseobacterium
sp. CA49) 		no annotation 5 ALA A  23
GLY A  30
SER A  58
ASP A  37
ALA A  14
 None
 1.27A 5zvgB-5x8hA:
7.0		 5zvgB-5x8hA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8j THYMIDYLATE KINASE

(Thermus
thermophilus) 		no annotation 5 ALA A  24
PRO A  33
GLY A  31
ASP A  90
ALA A  20
 None
None
None
FMT  A 201 ( 4.6A)
None
 1.03A 5zvgB-5x8jA:
undetectable		 5zvgB-5x8jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zct -

(-) 		no annotation 5 ALA A   4
GLY A  10
LYS A   2
ASP A  59
ALA A  60
 None
 1.33A 5zvgB-5zctA:
2.3		 5zvgB-5zctA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c43 GAMMA-AMINOBUTYRALDE
HYDE DEHYDROGENASE

(Salmonella
enterica) 		no annotation 6 ALA A 164
PRO A 138
GLY A  56
ALA A 114
PRO A 161
PHE A 111
 None
 1.34A 5zvgB-6c43A:
undetectable		 5zvgB-6c43A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cwr -

(-) 		no annotation 5 ALA A  41
GLY A  73
SER A  45
ASP A  36
ALA A  37
 None
 1.33A 5zvgB-6cwrA:
undetectable		 5zvgB-6cwrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ejf -

(-) 		no annotation 5 ALA G 404
PRO G 409
LYS G 451
ASP G 398
PRO G 402
 None
 1.34A 5zvgB-6ejfG:
undetectable		 5zvgB-6ejfG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gc6 50S RIBOSOMAL
PROTEIN L2

(Escherichia
coli) 		no annotation 5 PRO C 125
GLY C 108
ASP C  65
ARG C 101
TYR C  95
 None
 1.15A 5zvgB-6gc6C:
undetectable		 5zvgB-6gc6C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxn PROTEIN (RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN)

(Cupriavidus
necator) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		3 ASP A 201
ARG A 423
ASP A 166
 None
 0.82A 5zvgB-1bxnA:
undetectable		 5zvgB-1bxnA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3h GUANOSINE
PENTAPHOSPHATE
SYNTHETASE

(Streptomyces
antibioticus) 		PF00013
(KH_1)
PF01138
(RNase_PH)
PF03726
(PNPase) 		3 ASP A  42
ARG A  20
ASP A 130
 None
 0.84A 5zvgB-1e3hA:
undetectable		 5zvgB-1e3hA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gs9 APOLIPOPROTEIN E

(Homo sapiens) 		PF01442
(Apolipoprotein) 		3 ASP A 151
ARG A 103
ASP A 110
 None
 0.74A 5zvgB-1gs9A:
undetectable		 5zvgB-1gs9A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h54 MALTOSE
PHOSPHORYLASE

(Lactobacillus
brevis) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		3 ASP A  41
ARG A  39
ASP A  49
 None
 0.75A 5zvgB-1h54A:
undetectable		 5zvgB-1h54A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h81 POLYAMINE OXIDASE

(Zea mays) 		PF01593
(Amino_oxidase) 		3 ASP A 416
ARG A 412
ASP A 449
 None
 0.86A 5zvgB-1h81A:
2.1		 5zvgB-1h81A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hg0 L-ASPARAGINASE

(Dickeya
chrysanthemi) 		PF00710
(Asparaginase) 		3 ASP A 130
ARG A 122
ASP A 175
 None
 0.79A 5zvgB-1hg0A:
undetectable		 5zvgB-1hg0A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i5p PESTICIDIAL CRYSTAL
PROTEIN CRY2AA

(Bacillus
thuringiensis) 		PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N)
PF09131
(Endotoxin_mid) 		3 ASP A 618
ARG A 524
ASP A 521
 None
 0.82A 5zvgB-1i5pA:
undetectable		 5zvgB-1i5pA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l2u OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Escherichia
coli) 		PF00215
(OMPdecase) 		3 ASP A  34
ARG A  64
ASP A  27
 None
 0.82A 5zvgB-1l2uA:
undetectable		 5zvgB-1l2uA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1miv TRNA CCA-ADDING
ENZYME

(Geobacillus
stearothermophilus) 		PF01743
(PolyA_pol)
PF12627
(PolyA_pol_RNAbd)
PF13735
(tRNA_NucTran2_2) 		3 ASP A 107
ARG A 110
ASP A  42
 None
 0.86A 5zvgB-1mivA:
undetectable		 5zvgB-1mivA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qho ALPHA-AMYLASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		3 ASP A 518
ARG A 545
ASP A   9
 None
 0.82A 5zvgB-1qhoA:
undetectable		 5zvgB-1qhoA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qxo CHORISMATE SYNTHASE

(Streptococcus
pneumoniae) 		PF01264
(Chorismate_synt) 		3 ASP A 123
ARG A 125
ASP A 112
 None
 0.79A 5zvgB-1qxoA:
undetectable		 5zvgB-1qxoA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1slq VP4

(Rotavirus A) 		PF17477
(Rota_VP4_MID)
PF17478
(VP4_helical) 		3 ASP A 478
ARG A 363
ASP A 253
 None
 0.88A 5zvgB-1slqA:
undetectable		 5zvgB-1slqA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vfg POLY A POLYMERASE

(Aquifex
aeolicus) 		PF01743
(PolyA_pol) 		3 ASP A 100
ARG A  79
ASP A  33
 None
None
APC  A 500 ( 4.8A)
 0.89A 5zvgB-1vfgA:
undetectable		 5zvgB-1vfgA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrn PHOTOSYNTHETIC
REACTION CENTER
CYTOCHROME C SUBUNIT

(Blastochloris
viridis) 		PF02276
(CytoC_RC) 		3 ASP C 304
ARG C 146
ASP C 238
 None
 0.74A 5zvgB-1vrnC:
undetectable		 5zvgB-1vrnC:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq2 BETA-GALACTOSIDASE

(Arthrobacter
sp. C2-2) 		PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		3 ASP A 929
ARG A 955
ASP A 714
 None
 0.82A 5zvgB-1yq2A:
undetectable		 5zvgB-1yq2A:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aeu HYPOTHETICAL PROTEIN
MJ0158

(Methanocaldococcus
jannaschii) 		PF03841
(SelA) 		3 ASP A 351
ARG A 350
ASP A  28
 None
SO4  A1010 (-2.6A)
None
 0.89A 5zvgB-2aeuA:
3.1		 5zvgB-2aeuA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2an2 P332G A333S DOUBLE
MUTANT OF NITRIC
OXIDE SYNTHASE FROM
BACILLUS SUBTILIS

(Bacillus
subtilis) 		PF02898
(NO_synthase) 		3 ASP A 141
ARG A 128
ASP A 247
 None
ARG  A2000 (-4.0A)
None
 0.89A 5zvgB-2an2A:
undetectable		 5zvgB-2an2A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2axq SACCHAROPINE
DEHYDROGENASE

(Saccharomyces
cerevisiae) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		3 ASP A 337
ARG A 176
ASP A 266
 None
 0.72A 5zvgB-2axqA:
3.7		 5zvgB-2axqA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		3 ASP A 258
ARG A 263
ASP A 305
 SAM  A1201 (-2.6A)
SAM  A1201 (-3.9A)
SAM  A1201 (-3.7A)
 0.71A 5zvgB-2b9eA:
30.7		 5zvgB-2b9eA:
26.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bq8 TARTRATE-RESISTANT
ACID PHOSPHATASE
TYPE 5

(Homo sapiens) 		PF00149
(Metallophos) 		3 ASP X  62
ARG X  64
ASP X  91
 None
 0.85A 5zvgB-2bq8X:
undetectable		 5zvgB-2bq8X:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cy8 D-PHENYLGLYCINE
AMINOTRANSFERASE

(Pseudomonas
stutzeri) 		PF00202
(Aminotran_3) 		3 ASP A  27
ARG A  22
ASP A  37
 None
 0.88A 5zvgB-2cy8A:
undetectable		 5zvgB-2cy8A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E

(Methanothermobacter
thermautotrophicus;
Methanothermobacter
thermautotrophicus) 		PF00710
(Asparaginase)
PF02637
(GatB_Yqey)
PF02934
(GatB_N)
PF02938
(GAD) 		3 ASP A 241
ARG C  43
ASP A 261
 None
 0.83A 5zvgB-2d6fA:
undetectable		 5zvgB-2d6fA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eid GALACTOSE OXIDASE

(Fusarium
graminearum) 		PF00754
(F5_F8_type_C)
PF01344
(Kelch_1)
PF09118
(DUF1929) 		3 ASP A 324
ARG A 330
ASP A 407
 None
 0.83A 5zvgB-2eidA:
undetectable		 5zvgB-2eidA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6d GLUCOAMYLASE GLU1

(Saccharomycopsis
fibuligera) 		PF00723
(Glyco_hydro_15) 		3 ASP A 160
ARG A 156
ASP A  84
 None
 0.69A 5zvgB-2f6dA:
undetectable		 5zvgB-2f6dA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ip1 TRYPTOPHANYL-TRNA
SYNTHETASE

(Saccharomyces
cerevisiae) 		PF00579
(tRNA-synt_1b) 		3 ASP A 313
ARG A 317
ASP A 142
 None
 0.85A 5zvgB-2ip1A:
undetectable		 5zvgB-2ip1A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jk0 L-ASPARAGINASE

(Pectobacterium
carotovorum) 		PF00710
(Asparaginase) 		3 ASP A 130
ARG A 122
ASP A 175
 None
 0.80A 5zvgB-2jk0A:
undetectable		 5zvgB-2jk0A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k4z DSRR

(Allochromatium
vinosum) 		PF01521
(Fe-S_biosyn) 		3 ASP A  51
ARG A  27
ASP A  66
 None
 0.75A 5zvgB-2k4zA:
undetectable		 5zvgB-2k4zA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k7b CALCIUM-BINDING
PROTEIN 1

(Homo sapiens) 		PF13499
(EF-hand_7) 		3 ASP A  46
ARG A  45
ASP A  39
 None
None
MG  A 601 (-3.5A)
 0.89A 5zvgB-2k7bA:
undetectable		 5zvgB-2k7bA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kbq HARMONIN

(Homo sapiens) 		no annotation 3 ASP A  14
ARG A  10
ASP A  20
 None
 0.82A 5zvgB-2kbqA:
undetectable		 5zvgB-2kbqA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m5t HUMAN RHINOVIRUS 2A
PROTEINASE

(Rhinovirus C) 		PF00947
(Pico_P2A) 		3 ASP A 131
ARG A 133
ASP A  75
 None
 0.71A 5zvgB-2m5tA:
undetectable		 5zvgB-2m5tA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o61 TRANSCRIPTION FACTOR
P65/INTERFERON
REGULATORY FACTOR
7/INTERFERON
REGULATORY FACTOR 3
FUSION PROTEIN

(Homo sapiens) 		PF00554
(RHD_DNA_bind)
PF00605
(IRF)
PF16179
(RHD_dimer) 		3 ASP A2069
ARG A2068
ASP A1114
 None
 0.76A 5zvgB-2o61A:
undetectable		 5zvgB-2o61A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbl PUTATIVE
ESTERASE/LIPASE/THIO
ESTERASE

(Ruegeria sp.
TM1040) 		PF07859
(Abhydrolase_3) 		3 ASP A  53
ARG A  31
ASP A  77
 None
 0.83A 5zvgB-2pblA:
undetectable		 5zvgB-2pblA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rcq RETINOL-BINDING
PROTEIN II, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		3 ASP A   3
ARG A 137
ASP A  43
 None
 0.73A 5zvgB-2rcqA:
undetectable		 5zvgB-2rcqA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rcq RETINOL-BINDING
PROTEIN II, CELLULAR

(Homo sapiens) 		PF00061
(Lipocalin) 		3 ASP A   3
ARG A 137
ASP A  45
 None
 0.65A 5zvgB-2rcqA:
undetectable		 5zvgB-2rcqA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vak SIGMA A

(Avian
orthoreovirus) 		PF03084
(Sigma_1_2) 		3 ASP A 257
ARG A 252
ASP A 286
 None
 0.61A 5zvgB-2vakA:
undetectable		 5zvgB-2vakA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		3 ASP A 408
ARG A 404
ASP A 311
 None
 0.75A 5zvgB-2vdcA:
undetectable		 5zvgB-2vdcA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vp3 VP39

(Vaccinia virus) 		PF01358
(PARP_regulatory) 		3 ASP A  95
ARG A  97
ASP A 138
 SAH  A 400 (-2.6A)
SAH  A 400 (-3.9A)
SAH  A 400 (-3.7A)
 0.78A 5zvgB-2vp3A:
8.3		 5zvgB-2vp3A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjq CEL44C

(Paenibacillus
polymyxa) 		PF12891
(Glyco_hydro_44) 		3 ASP A 282
ARG A  44
ASP A 185
 None
 0.89A 5zvgB-2yjqA:
undetectable		 5zvgB-2yjqA:
21.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN

(Pyrococcus
horikoshii) 		PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N) 		3 ASP A 291
ARG A 296
ASP A 337
 SFG  A5748 (-2.9A)
SFG  A5748 (-3.0A)
SFG  A5748 (-3.6A)
 0.89A 5zvgB-2yxlA:
38.5		 5zvgB-2yxlA:
32.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zuf ARGINYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		3 ASP A  40
ARG A 547
ASP A  35
 None
 0.87A 5zvgB-2zufA:
undetectable		 5zvgB-2zufA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3akc CYTIDYLATE KINASE

(Thermus
thermophilus) 		PF02224
(Cytidylate_kin) 		3 ASP A 175
ARG A 126
ASP A  94
 CDP  A 209 (-2.8A)
CDP  A 209 (-3.0A)
None
 0.82A 5zvgB-3akcA:
undetectable		 5zvgB-3akcA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5w PP2A-SPECIFIC
METHYLESTERASE PME-1

(Homo sapiens) 		PF12697
(Abhydrolase_6) 		3 ASP P 354
ARG P 222
ASP P 181
 None
 0.87A 5zvgB-3c5wP:
undetectable		 5zvgB-3c5wP:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e5m NMRA-LIKE FAMILY
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF05368
(NmrA) 		3 ASP A 186
ARG A 218
ASP A 269
 None
 0.88A 5zvgB-3e5mA:
6.0		 5zvgB-3e5mA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3en0 CYANOPHYCINASE

(Synechocystis
sp. PCC 6803) 		PF03575
(Peptidase_S51) 		3 ASP A 172
ARG A 180
ASP A 158
 None
SO4  A 272 (-4.5A)
None
 0.88A 5zvgB-3en0A:
undetectable		 5zvgB-3en0A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3frm UNCHARACTERIZED
CONSERVED PROTEIN

(Staphylococcus
epidermidis) 		PF13673
(Acetyltransf_10) 		3 ASP A 177
ARG A 163
ASP A  12
 None
 0.72A 5zvgB-3frmA:
undetectable		 5zvgB-3frmA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7u ALDO-KETO REDUCTASE

(Arabidopsis
thaliana) 		PF00248
(Aldo_ket_red) 		3 ASP A 109
ARG A 153
ASP A  75
 None
 0.73A 5zvgB-3h7uA:
undetectable		 5zvgB-3h7uA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k0z PUTATIVE POLYKETIDE
CYCLASE

(Bacillus cereus) 		PF07366
(SnoaL) 		3 ASP A  84
ARG A  91
ASP A 147
 None
NHE  A   1 (-3.9A)
None
 0.80A 5zvgB-3k0zA:
undetectable		 5zvgB-3k0zA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kh8 MAOC-LIKE
DEHYDRATASE

(Phytophthora
capsici) 		PF01575
(MaoC_dehydratas)
PF13452
(MaoC_dehydrat_N) 		3 ASP A  24
ARG A  23
ASP A  65
 None
 0.82A 5zvgB-3kh8A:
undetectable		 5zvgB-3kh8A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l10 PROLIFERATING CELL
NUCLEAR ANTIGEN

(Saccharomyces
cerevisiae) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		3 ASP A  63
ARG A  61
ASP A  93
 None
 0.76A 5zvgB-3l10A:
undetectable		 5zvgB-3l10A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lah METHYL-ACCEPTING
CHEMOTAXIS PROTEIN

(Caldanaerobacter
subterraneus) 		PF07700
(HNOB) 		3 ASP A  45
ARG A 135
ASP A  42
 None
HEM  A 200 (-3.6A)
None
 0.82A 5zvgB-3lahA:
undetectable		 5zvgB-3lahA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qyf CRISPR-ASSOCIATED
PROTEIN

(Sulfolobus
solfataricus) 		PF09651
(Cas_APE2256) 		3 ASP A  74
ARG A  67
ASP A 195
 None
None
MG  A 322 (-2.2A)
 0.82A 5zvgB-3qyfA:
2.4		 5zvgB-3qyfA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1

(Mus musculus) 		PF00400
(WD40)
PF00931
(NB-ARC)
PF12894
(ANAPC4_WD40) 		3 ASP A 626
ARG A 629
ASP A 668
 None
 0.79A 5zvgB-3sfzA:
undetectable		 5zvgB-3sfzA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tos CALS11

(Micromonospora
echinospora) 		PF05711
(TylF) 		3 ASP A 151
ARG A  91
ASP A 145
 None
 0.78A 5zvgB-3tosA:
9.2		 5zvgB-3tosA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqw METHIONINE-BINDING
PROTEIN

(Coxiella
burnetii) 		PF03180
(Lipoprotein_9) 		3 ASP A  51
ARG A   3
ASP A  47
 None
 0.81A 5zvgB-3tqwA:
undetectable		 5zvgB-3tqwA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ucq AMYLOSUCRASE

(Deinococcus
geothermalis) 		PF00128
(Alpha-amylase) 		3 ASP A 175
ARG A 282
ASP A 137
 None
GOL  A 721 (-3.4A)
GOL  A 720 (-2.6A)
 0.89A 5zvgB-3ucqA:
undetectable		 5zvgB-3ucqA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		3 ASP A 247
ARG A 248
ASP A  11
 ZN  A 474 ( 2.5A)
GOL  A 472 ( 4.0A)
None
 0.85A 5zvgB-3uw2A:
undetectable		 5zvgB-3uw2A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wec CYTOCHROME P450

(Rhodococcus
erythropolis) 		PF00067
(p450) 		3 ASP A 241
ARG A 212
ASP A  94
 None
 0.79A 5zvgB-3wecA:
undetectable		 5zvgB-3wecA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wmx NAD DEPENDENT
EPIMERASE/DEHYDRATAS
E

(Cupriavidus
necator) 		PF01370
(Epimerase) 		3 ASP A 165
ARG A 113
ASP A 233
 None
 0.86A 5zvgB-3wmxA:
5.7		 5zvgB-3wmxA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a1o BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Mycobacterium
tuberculosis) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		3 ASP A 273
ARG A 269
ASP A 389
 None
 0.85A 5zvgB-4a1oA:
undetectable		 5zvgB-4a1oA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e0t CYCLIC DIPEPTIDE
N-PRENYLTRANSFERASE

(Aspergillus
fumigatus) 		PF11991
(Trp_DMAT) 		3 ASP A 291
ARG A 298
ASP A 269
 None
 0.89A 5zvgB-4e0tA:
undetectable		 5zvgB-4e0tA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		3 ASP A 204
ARG A 209
ASP A 255
 SAM  A 401 (-2.9A)
SAM  A 401 (-3.6A)
SAM  A 401 (-3.7A)
 0.34A 5zvgB-4fzvA:
28.5		 5zvgB-4fzvA:
27.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3n DNA GYRASE SUBUNIT A

(Mycobacterium
tuberculosis) 		PF03989
(DNA_gyraseA_C) 		3 ASP A 565
ARG A 615
ASP A 515
 None
 0.88A 5zvgB-4g3nA:
undetectable		 5zvgB-4g3nA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gkl ALPHA-AMYLASE

(Thermotoga
neapolitana) 		PF00128
(Alpha-amylase) 		3 ASP A 138
ARG A 128
ASP A 169
 None
 0.79A 5zvgB-4gklA:
undetectable		 5zvgB-4gklA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i0k CD276 ANTIGEN

(Mus musculus) 		PF07686
(V-set)
PF13927
(Ig_3) 		3 ASP A 116
ARG A 113
ASP A  45
 None
SO4  A 306 (-2.4A)
None
 0.64A 5zvgB-4i0kA:
undetectable		 5zvgB-4i0kA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4khb UNCHARACTERIZED
PROTEIN POB3N

(Chaetomium
thermophilum) 		no annotation 3 ASP D  79
ARG D  82
ASP D   8
 None
 0.89A 5zvgB-4khbD:
undetectable		 5zvgB-4khbD:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mwg PUTATIVE
DIHYDROMETHANOPTERIN
REDUCTASE (AFPA)

(Paraburkholderia
xenovorans) 		PF02441
(Flavoprotein) 		3 ASP A  43
ARG A  69
ASP A  15
 None
 0.87A 5zvgB-4mwgA:
undetectable		 5zvgB-4mwgA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oec GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Thermococcus
kodakarensis) 		PF03009
(GDPD) 		3 ASP A 155
ARG A 156
ASP A 134
 None
 0.90A 5zvgB-4oecA:
undetectable		 5zvgB-4oecA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ow2 YOP EFFECTOR YOPM

(Yersinia
enterocolitica) 		PF12468
(TTSSLRR) 		3 ASP A 399
ARG A 361
ASP A 422
 None
 0.89A 5zvgB-4ow2A:
undetectable		 5zvgB-4ow2A:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pyr PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER

(Chromobacterium
violaceum) 		PF04348
(LppC) 		3 ASP A 115
ARG A 317
ASP A 338
 None
 0.79A 5zvgB-4pyrA:
undetectable		 5zvgB-4pyrA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pyr PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER

(Chromobacterium
violaceum) 		PF04348
(LppC) 		3 ASP A 338
ARG A 341
ASP A 363
 None
 0.83A 5zvgB-4pyrA:
undetectable		 5zvgB-4pyrA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgk UNCHARACTERIZED
PROTEIN

(Yersinia pestis) 		PF07350
(DUF1479) 		3 ASP A 183
ARG A 184
ASP A 202
 EDO  A 505 ( 4.3A)
None
SO4  A 506 (-2.8A)
 0.81A 5zvgB-4rgkA:
undetectable		 5zvgB-4rgkA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd1 ACETOACETATE-COA
LIGASE

(Streptomyces
lividans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		3 ASP A 406
ARG A 402
ASP A 414
 EDO  A 708 (-4.7A)
None
None
 0.78A 5zvgB-4wd1A:
undetectable		 5zvgB-4wd1A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xl5 BGFP-A

(synthetic
construct) 		PF02985
(HEAT)
PF13646
(HEAT_2) 		3 ASP C  74
ARG C  76
ASP C  43
 None
 0.85A 5zvgB-4xl5C:
undetectable		 5zvgB-4xl5C:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ydh FORMIN-LIKE PROTEIN
1

(Homo sapiens) 		PF06367
(Drf_FH3)
PF06371
(Drf_GBD) 		3 ASP A 294
ARG A 305
ASP A 287
 None
 0.86A 5zvgB-4ydhA:
undetectable		 5zvgB-4ydhA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yxf MUPS

(Pseudomonas
fluorescens) 		PF13561
(adh_short_C2) 		3 ASP A 239
ARG A 240
ASP A 232
 None
 0.89A 5zvgB-4yxfA:
5.5		 5zvgB-4yxfA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zc0 REPLICATIVE DNA
HELICASE

(Helicobacter
pylori) 		PF00772
(DnaB)
PF03796
(DnaB_C) 		3 ASP A 381
ARG A 336
ASP A 374
 None
 0.61A 5zvgB-4zc0A:
undetectable		 5zvgB-4zc0A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7t TRNA
(ADENINE(9)-N1)-METH
YLTRANSFERASE

(Sulfolobus
acidocaldarius) 		no annotation 3 ASP A 159
ARG A 187
ASP A  93
 None
 0.80A 5zvgB-5a7tA:
undetectable		 5zvgB-5a7tA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ady GTPASE HFLX

(Escherichia
coli) 		PF01926
(MMR_HSR1)
PF13167
(GTP-bdg_N)
PF16360
(GTP-bdg_M) 		3 ASP 6  81
ARG 6 103
ASP 6  26
 None
 0.65A 5zvgB-5ady6:
undetectable		 5zvgB-5ady6:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7n MTA/SAH NUCLEOSIDASE

(Aeromonas
hydrophila) 		PF01048
(PNP_UDP_1) 		3 ASP A 116
ARG A 187
ASP A 109
 None
 0.87A 5zvgB-5b7nA:
undetectable		 5zvgB-5b7nA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dfa BETA-GALACTOSIDASE

(Geobacillus
stearothermophilus) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		3 ASP A 606
ARG A 549
ASP A 601
 None
 0.83A 5zvgB-5dfaA:
undetectable		 5zvgB-5dfaA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dwu CYTOKINE RECEPTOR
COMMON SUBUNIT BETA
CYTOKINE RECEPTOR
COMMON SUBUNIT BETA

(Homo sapiens;
Homo sapiens) 		no annotation
PF00041
(fn3)
PF09240
(IL6Ra-bind) 		3 ASP A 116
ARG A 117
ASP B 241
 NAG  A 301 ( 4.9A)
None
None
 0.71A 5zvgB-5dwuA:
undetectable		 5zvgB-5dwuA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fic SPHINGOMYELIN
PHOSPHODIESTERASE

(Mus musculus) 		PF00149
(Metallophos) 		3 ASP A 208
ARG A 226
ASP A 289
 None
 0.88A 5zvgB-5ficA:
undetectable		 5zvgB-5ficA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fw4 DYE-DECOLORIZING
PEROXIDASE TFU_3078

(Thermobifida
fusca) 		PF04261
(Dyp_perox) 		3 ASP A 356
ARG A 352
ASP A 134
 None
 0.84A 5zvgB-5fw4A:
undetectable		 5zvgB-5fw4A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gjv VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S

(Oryctolagus
cuniculus) 		PF00520
(Ion_trans)
PF08763
(Ca_chan_IQ)
PF16905
(GPHH) 		3 ASP A1196
ARG A1236
ASP A1203
 None
 0.81A 5zvgB-5gjvA:
undetectable		 5zvgB-5gjvA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gt5 PECTATE LYASE

(Paenibacillus
sp. 0602) 		no annotation 3 ASP A 178
ARG A 276
ASP A 150
 None
 0.79A 5zvgB-5gt5A:
undetectable		 5zvgB-5gt5A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iva LPS-ASSEMBLY PROTEIN
LPTD

(Pseudomonas
aeruginosa) 		PF04453
(OstA_C) 		3 ASP A 562
ARG A 567
ASP A 536
 None
 0.88A 5zvgB-5ivaA:
undetectable		 5zvgB-5ivaA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j46 PEPTIDE DEFORMYLASE

(Burkholderia
multivorans) 		PF01327
(Pep_deformylase) 		3 ASP A  39
ARG A  41
ASP A  36
 None
 0.63A 5zvgB-5j46A:
undetectable		 5zvgB-5j46A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jh1 ALDOSE REDUCTASE,
AKR4C7

(Zea mays) 		PF00248
(Aldo_ket_red) 		3 ASP A 106
ARG A 149
ASP A  72
 None
 0.79A 5zvgB-5jh1A:
undetectable		 5zvgB-5jh1A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jp9 CMP
5-HYDROXYMETHYLASE

(Streptomyces
rimofaciens) 		PF00303
(Thymidylat_synt) 		3 ASP A 305
ARG A 306
ASP A 274
 None
 0.85A 5zvgB-5jp9A:
undetectable		 5zvgB-5jp9A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzv NANOBODY 22E11

(Lama glama) 		no annotation 3 ASP D  66
ARG D  67
ASP D  62
 None
 0.69A 5zvgB-5mzvD:
undetectable		 5zvgB-5mzvD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6v AMYLOSUCRASE

(Neisseria
polysaccharea) 		no annotation 3 ASP A 182
ARG A 284
ASP A 144
 None
TRS  A 701 ( 4.6A)
TRS  A 701 (-2.8A)
 0.83A 5zvgB-5n6vA:
undetectable		 5zvgB-5n6vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ocp -

(-) 		no annotation 3 ASP A  88
ARG A  89
ASP A 223
 AHR  A 407 ( 2.6A)
FUB  A 408 ( 3.9A)
AHR  A 407 ( 2.8A)
 0.88A 5zvgB-5ocpA:
2.2		 5zvgB-5ocpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tg8 HEMAGGLUTININ HA1
CHAIN

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		3 ASP A 298
ARG A 300
ASP A 271
 None
 0.71A 5zvgB-5tg8A:
undetectable		 5zvgB-5tg8A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wm4 SALICYLATE-AMP
LIGASE

(Streptomyces
gandocaensis) 		no annotation 3 ASP A 226
ARG A  37
ASP A 204
 None
 0.83A 5zvgB-5wm4A:
undetectable		 5zvgB-5wm4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z5k NETRIN RECEPTOR DCC
DRAXIN

(Rattus
norvegicus;
Rattus
norvegicus) 		no annotation
no annotation 		3 ASP B 300
ARG B 308
ASP A  77
 None
 0.82A 5zvgB-5z5kB:
undetectable		 5zvgB-5z5kB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b0e 1260 ANTIBODY, HEAVY
CHAIN

(Homo sapiens) 		no annotation 3 ASP B  95
ARG B  96
ASP B  58
 None
 0.58A 5zvgB-6b0eB:
undetectable		 5zvgB-6b0eB:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byo VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S

(Oryctolagus
cuniculus) 		no annotation 3 ASP A1196
ARG A1236
ASP A1203
 None
 0.83A 5zvgB-6byoA:
undetectable		 5zvgB-6byoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d3u ULVAN LYASE

(Nonlabens
ulvanivorans) 		no annotation 3 ASP A 109
ARG A  64
ASP A 173
 None
None
PO4  A 403 ( 4.1A)
 0.84A 5zvgB-6d3uA:
undetectable		 5zvgB-6d3uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dg4 ULP1-LIKE SUMO
PROTEASE

(Chaetomium
thermophilum) 		no annotation 3 ASP A  48
ARG A  47
ASP A  62
 None
GOL  A 303 (-2.6A)
None
 0.63A 5zvgB-6dg4A:
undetectable		 5zvgB-6dg4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoj PROTEIN CFT1

(Saccharomyces
cerevisiae) 		no annotation 3 ASP A 856
ARG A 900
ASP A 793
 None
 0.70A 5zvgB-6eojA:
undetectable		 5zvgB-6eojA:
15.15