SIMILAR PATTERNS OF AMINO ACIDS FOR 5ZV2_B_LEVB801_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0c XYLOSE ISOMERASE

(Thermoanaerobacterium
thermosulfurigenes) 		PF01261
(AP_endonuc_2) 		3 TYR A 261
LEU A 253
ASP A 243
 None
 0.88A 5zv2B-1a0cA:
undetectable		 5zv2B-1a0cA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgp ARISTOLOCHENE
SYNTHASE

(Penicillium
roqueforti) 		no annotation 3 TYR A 319
LEU A 232
ASP A 299
 None
 0.86A 5zv2B-1dgpA:
undetectable		 5zv2B-1dgpA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f1u HOMOPROTOCATECHUATE
2,3-DIOXYGENASE

(Arthrobacter
globiformis) 		PF00903
(Glyoxalase) 		3 TYR A  35
LEU A  28
ASP A  47
 None
 0.79A 5zv2B-1f1uA:
undetectable		 5zv2B-1f1uA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iko EPHRIN-B2

(Mus musculus) 		PF00812
(Ephrin) 		3 TYR P  76
LEU P 145
ASP P 149
 None
 0.86A 5zv2B-1ikoP:
undetectable		 5zv2B-1ikoP:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j08 GLUTAREDOXIN-LIKE
PROTEIN

(Pyrococcus
horikoshii) 		PF00085
(Thioredoxin)
PF13192
(Thioredoxin_3) 		3 TYR A 181
LEU A 139
ASP A 204
 None
 0.72A 5zv2B-1j08A:
undetectable		 5zv2B-1j08A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		3 TYR A 268
LEU A 321
ASP A 332
 None
 0.60A 5zv2B-1k9aA:
26.0		 5zv2B-1k9aA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qwr MANNOSE-6-PHOSPHATE
ISOMERASE

(Bacillus
subtilis) 		PF01238
(PMI_typeI) 		3 TYR A 247
LEU A 112
ASP A  78
 None
 0.89A 5zv2B-1qwrA:
undetectable		 5zv2B-1qwrA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		3 TYR A 107
LEU A 158
ASP A 169
 None
 0.83A 5zv2B-1u5qA:
23.9		 5zv2B-1u5qA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkn PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE

(Chlorobaculum
tepidum) 		PF04371
(PAD_porph) 		3 TYR A 301
LEU A 282
ASP A 278
 None
 0.85A 5zv2B-1xknA:
undetectable		 5zv2B-1xknA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yd9 CORE HISTONE
MACRO-H2A.1

(Rattus
norvegicus) 		PF01661
(Macro) 		3 TYR A 183
LEU A  21
ASP A 191
 None
 0.86A 5zv2B-1yd9A:
undetectable		 5zv2B-1yd9A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		3 TYR A  86
LEU A 137
ASP A 148
 HYM  A 400 (-4.7A)
HYM  A 400 (-4.5A)
HYM  A 400 (-3.9A)
 0.70A 5zv2B-1zltA:
15.3		 5zv2B-1zltA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ako GLUTAMATE 5-KINASE

(Campylobacter
jejuni) 		PF00696
(AA_kinase) 		3 TYR A 168
LEU A 226
ASP A 143
 None
None
ADP  A 852 ( 4.6A)
 0.61A 5zv2B-2akoA:
undetectable		 5zv2B-2akoA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 TYR X  84
LEU X 137
ASP X 148
 STU  X 902 (-4.6A)
STU  X 902 (-4.4A)
STU  X 902 (-3.6A)
 0.64A 5zv2B-2dq7X:
30.2		 5zv2B-2dq7X:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2erc RRNA METHYL
TRANSFERASE

(Bacillus
subtilis) 		PF00398
(RrnaAD) 		3 TYR A 129
LEU A 136
ASP A 151
 None
 0.71A 5zv2B-2ercA:
undetectable		 5zv2B-2ercA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		3 TYR A 107
LEU A 158
ASP A 169
 STU  A 400 (-4.5A)
STU  A 400 ( 4.6A)
STU  A 400 (-3.6A)
 0.79A 5zv2B-2gcdA:
24.5		 5zv2B-2gcdA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwn DIHYDROOROTASE

(Porphyromonas
gingivalis) 		PF01979
(Amidohydro_1) 		3 TYR A 199
LEU A 210
ASP A 273
 None
 0.71A 5zv2B-2gwnA:
undetectable		 5zv2B-2gwnA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		3 TYR A 340
LEU A 393
ASP A 404
 H8H  A 534 (-4.3A)
H8H  A 534 (-4.5A)
H8H  A 534 (-4.2A)
 0.62A 5zv2B-2h8hA:
29.4		 5zv2B-2h8hA:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iu3 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Gallus gallus) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		3 TYR A 152
LEU A  25
ASP A 166
 None
 0.83A 5zv2B-2iu3A:
undetectable		 5zv2B-2iu3A:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nun AVIRULENCE B PROTEIN

(Pseudomonas
savastanoi) 		PF05394
(AvrB_AvrC) 		3 TYR A 222
LEU A 168
ASP A 232
 None
 0.89A 5zv2B-2nunA:
undetectable		 5zv2B-2nunA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ose PROBABLE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Mimivirus) 		PF00160
(Pro_isomerase) 		3 TYR A 121
LEU A 128
ASP A 153
 None
 0.82A 5zv2B-2oseA:
undetectable		 5zv2B-2oseA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmo SER/THR PROTEIN
KINASE

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		3 TYR X 119
LEU X 179
ASP X 190
 HMD  X 400 (-4.5A)
HMD  X 400 (-4.7A)
HMD  X 400 (-3.7A)
 0.67A 5zv2B-2pmoX:
20.7		 5zv2B-2pmoX:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyw UNCHARACTERIZED
PROTEIN

(Arabidopsis
thaliana) 		PF01636
(APH) 		3 TYR A 158
LEU A 317
ASP A 145
 None
 0.72A 5zv2B-2pywA:
8.0		 5zv2B-2pywA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkw PROTEIN KINASE

(Solanum
pimpinellifolium) 		PF07714
(Pkinase_Tyr) 		3 TYR B 116
LEU B 171
ASP B 182
 None
 0.70A 5zv2B-2qkwB:
23.3		 5zv2B-2qkwB:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyk CYCLIC AMP-SPECIFIC
PHOSPHODIESTERASE
HSPDE4A10

(Homo sapiens) 		PF00233
(PDEase_I) 		3 TYR A 371
LEU A 375
ASP A 323
 NPV  A   3 (-4.4A)
None
None
 0.87A 5zv2B-2qykA:
undetectable		 5zv2B-2qykA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uzz N-METHYL-L-TRYPTOPHA
N OXIDASE

(Escherichia
coli) 		PF01266
(DAO) 		3 TYR A  54
LEU A  63
ASP A 362
 None
 0.78A 5zv2B-2uzzA:
undetectable		 5zv2B-2uzzA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd5 DMPK PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		3 TYR A 150
LEU A 202
ASP A 213
 BI8  A1417 (-4.8A)
BI8  A1417 (-4.8A)
BI8  A1417 (-3.8A)
 0.84A 5zv2B-2vd5A:
19.6		 5zv2B-2vd5A:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz9 FATTY ACID SYNTHASE

(Sus scrofa) 		PF00107
(ADH_zinc_N)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08242
(Methyltransf_12)
PF08659
(KR)
PF14765
(PS-DH)
PF16197
(KAsynt_C_assoc) 		3 TYR A 993
LEU A1011
ASP A1073
 None
 0.77A 5zv2B-2vz9A:
undetectable		 5zv2B-2vz9A:
2.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xik SERINE/THREONINE
PROTEIN KINASE 25

(Homo sapiens) 		PF00069
(Pkinase) 		3 TYR A  97
LEU A 147
ASP A 158
 J60  A1294 (-4.5A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.6A)
 0.70A 5zv2B-2xikA:
19.0		 5zv2B-2xikA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yij PHOSPHOLIPASE
A1-IIGAMMA

(Arabidopsis
thaliana) 		PF01764
(Lipase_3) 		3 TYR A  95
LEU A  86
ASP A  59
 None
 0.89A 5zv2B-2yijA:
undetectable		 5zv2B-2yijA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahy BETA-GLUCOSIDASE

(Trichoderma
reesei) 		PF00232
(Glyco_hydro_1) 		3 TYR A 263
LEU A 271
ASP A 314
 None
 0.83A 5zv2B-3ahyA:
undetectable		 5zv2B-3ahyA:
9.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 TYR A 563
LEU A 630
ASP A 641
 None
C4F  A   1 (-4.6A)
C4F  A   1 (-4.5A)
 0.31A 5zv2B-3c4fA:
18.1		 5zv2B-3c4fA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 TYR A 268
LEU A 321
ASP A 332
 None
 0.59A 5zv2B-3d7uA:
31.0		 5zv2B-3d7uA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dev SH1221

(Staphylococcus
haemolyticus) 		PF01368
(DHH)
PF02272
(DHHA1) 		3 TYR A  40
LEU A 151
ASP A  29
 None
None
MG  A 323 (-3.5A)
 0.86A 5zv2B-3devA:
undetectable		 5zv2B-3devA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2

(Homo sapiens) 		PF00069
(Pkinase) 		3 TYR A 281
LEU A 340
ASP A 351
 None
ADP  A 900 (-4.6A)
ADP  A 900 ( 2.7A)
 0.77A 5zv2B-3g2fA:
24.2		 5zv2B-3g2fA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbj KIF13B PROTEIN

(Homo sapiens) 		PF00225
(Kinesin) 		3 TYR A 182
LEU A 171
ASP A 163
 None
 0.75A 5zv2B-3gbjA:
undetectable		 5zv2B-3gbjA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
DNA-DIRECTED RNA
POLYMERASE, SUBUNIT
G (RPOG)

(Sulfolobus
solfataricus) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
PF16992
(RNA_pol_RpbG) 		3 TYR A 507
LEU G  23
ASP G  41
 None
 0.83A 5zv2B-3hkzA:
undetectable		 5zv2B-3hkzA:
6.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzh CHEMOTAXIS RESPONSE
REGULATOR (CHEY-3)

(Borreliella
burgdorferi) 		PF00072
(Response_reg) 		3 TYR A  66
LEU A  78
ASP A  86
 None
BFD  A  79 ( 3.7A)
None
 0.78A 5zv2B-3hzhA:
undetectable		 5zv2B-3hzhA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5g MYOSIN CATALYTIC
LIGHT CHAIN LC-1,
MANTLE MUSCLE

(Todarodes
pacificus) 		PF13405
(EF-hand_6) 		3 TYR C  72
LEU C  36
ASP C  19
 None
None
CA  C1001 (-4.5A)
 0.67A 5zv2B-3i5gC:
undetectable		 5zv2B-3i5gC:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jar MICROTUBULE-ASSOCIAT
ED PROTEIN RP/EB
FAMILY MEMBER 3

(Homo sapiens) 		no annotation 3 TYR N 124
LEU N  51
ASP N 116
 None
 0.85A 5zv2B-3jarN:
undetectable		 5zv2B-3jarN:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		3 TYR A 715
LEU A 767
ASP A 778
 GOL  A 403 (-4.1A)
None
None
 0.59A 5zv2B-3kulA:
28.3		 5zv2B-3kulA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lg5 EPI-ISOZIZAENE
SYNTHASE

(Streptomyces
coelicolor) 		no annotation 3 TYR A 172
LEU A 121
ASP A 136
 None
 0.85A 5zv2B-3lg5A:
undetectable		 5zv2B-3lg5A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		3 TYR A 112
LEU A 165
ASP A 179
 QUE  A   1 (-4.9A)
None
QUE  A   1 (-2.9A)
 0.71A 5zv2B-3lm5A:
23.8		 5zv2B-3lm5A:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		3 TYR A 281
LEU A 339
ASP A 350
 LDN  A   1 ( 4.8A)
LDN  A   1 (-4.5A)
LDN  A   1 (-3.9A)
 0.77A 5zv2B-3mdyA:
24.8		 5zv2B-3mdyA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mos TRANSKETOLASE

(Homo sapiens) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		3 TYR A  83
LEU A  73
ASP A 183
 None
EDO  A 627 (-4.4A)
TPP  A 700 ( 4.5A)
 0.84A 5zv2B-3mosA:
undetectable		 5zv2B-3mosA:
7.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ner CYTOCHROME B5 TYPE B

(Homo sapiens) 		PF00173
(Cyt-b5) 		3 TYR A   6
LEU A  84
ASP A  53
 None
 0.79A 5zv2B-3nerA:
undetectable		 5zv2B-3nerA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntc FAB HEAVY CHAIN
FAB LIGHT CHAIN

(Homo sapiens;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 TYR H 102
LEU L  46
ASP L  91
 None
None
EDO  H 220 ( 4.5A)
 0.61A 5zv2B-3ntcH:
undetectable		 5zv2B-3ntcH:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oiz ANTISIGMA-FACTOR
ANTAGONIST, STAS

(Rhodobacter
sphaeroides) 		PF01740
(STAS) 		3 TYR A 406
LEU A 397
ASP A 400
 None
 0.89A 5zv2B-3oizA:
undetectable		 5zv2B-3oizA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		3 TYR A  92
LEU A 141
ASP A 152
 None
 0.39A 5zv2B-3oz6A:
21.2		 5zv2B-3oz6A:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		3 TYR A 627
LEU A 683
ASP A 694
 STU  A   1 (-4.4A)
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
 0.49A 5zv2B-3ppzA:
27.9		 5zv2B-3ppzA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s95 LIM DOMAIN KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 TYR A 415
LEU A 467
ASP A 478
 STU  A   1 (-4.7A)
STU  A   1 (-4.6A)
STU  A   1 ( 4.2A)
 0.64A 5zv2B-3s95A:
25.1		 5zv2B-3s95A:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sun DNA POLYMERASE

(Escherichia
virus RB69) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		3 TYR A 349
LEU A  93
ASP A  87
 None
 0.69A 5zv2B-3sunA:
undetectable		 5zv2B-3sunA:
6.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 TYR A 563
LEU A 630
ASP A 641
 07J  A   1 (-4.7A)
07J  A   1 ( 4.4A)
07J  A   1 (-4.7A)
 0.52A 5zv2B-3tt0A:
40.0		 5zv2B-3tt0A:
59.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfp POLY A POLYMERASE

(Aquifex
aeolicus;
synthetic
construct) 		PF01743
(PolyA_pol)
PF01966
(HD)
PF12627
(PolyA_pol_RNAbd) 		3 TYR A 343
LEU A 378
ASP A 418
 None
 0.86A 5zv2B-3wfpA:
undetectable		 5zv2B-3wfpA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wj2 CARBOXYLESTERASE

(Ferroplasma
acidiphilum) 		PF07859
(Abhydrolase_3) 		3 TYR A 217
LEU A 117
ASP A  37
 None
 0.88A 5zv2B-3wj2A:
undetectable		 5zv2B-3wj2A:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4z ANTIVIRAL HELICASE
SKI2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		3 TYR A1286
LEU A 384
ASP A 444
 None
 0.62A 5zv2B-4a4zA:
undetectable		 5zv2B-4a4zA:
6.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b96 CELLULOSE BINDING
DOMAIN-CONTAINING
PROTEIN

([Clostridium]
clariflavum) 		PF00942
(CBM_3) 		3 TYR A  10
LEU A 124
ASP A 134
 None
 0.81A 5zv2B-4b96A:
undetectable		 5zv2B-4b96A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5

(Homo sapiens) 		PF00069
(Pkinase) 		3 TYR A  91
LEU A 142
ASP A 153
 38R  A1000 (-4.8A)
38R  A1000 ( 4.5A)
38R  A1000 ( 4.2A)
 0.80A 5zv2B-4bgqA:
17.6		 5zv2B-4bgqA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4by4 FI18190P1

(Drosophila
melanogaster) 		PF00036
(EF-hand_1)
PF13499
(EF-hand_7) 		3 TYR A 108
LEU A 163
ASP A 161
 None
 0.69A 5zv2B-4by4A:
undetectable		 5zv2B-4by4A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		3 TYR A 320
LEU A 371
ASP A 382
 None
 0.45A 5zv2B-4c0tA:
22.7		 5zv2B-4c0tA:
5.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		3 TYR A  95
LEU A 146
ASP A 157
 STU  A1550 (-4.5A)
STU  A1550 (-4.3A)
STU  A1550 (-3.6A)
 0.83A 5zv2B-4cfhA:
23.1		 5zv2B-4cfhA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		3 TYR A 739
LEU A 789
ASP A 800
 None
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
 0.78A 5zv2B-4crsA:
16.1		 5zv2B-4crsA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 TYR A 904
LEU A 956
ASP A 967
 19S  A1201 (-4.7A)
19S  A1201 (-4.5A)
19S  A1201 ( 4.1A)
 0.86A 5zv2B-4hviA:
24.1		 5zv2B-4hviA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		3 TYR A 340
LEU A 393
ASP A 404
 0J9  A 601 ( 4.7A)
0J9  A 601 (-4.5A)
0J9  A 601 (-3.1A)
 0.69A 5zv2B-4k11A:
29.3		 5zv2B-4k11A:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l68 LEUCINE-RICH REPEAT
PROTEIN KINASE-LIKE
PROTEIN

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		3 TYR A 381
LEU A 436
ASP A 447
 None
 0.66A 5zv2B-4l68A:
15.8		 5zv2B-4l68A:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mdp BETA-GLUCOSIDASE

(Humicola grisea) 		PF00232
(Glyco_hydro_1) 		3 TYR A 273
LEU A 281
ASP A 324
 PO4  A 505 ( 4.9A)
None
None
 0.86A 5zv2B-4mdpA:
undetectable		 5zv2B-4mdpA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ml1 DSBP

(Klebsiella
pneumoniae) 		PF10411
(DsbC_N)
PF13098
(Thioredoxin_2) 		3 TYR A 173
LEU A 177
ASP A 100
 None
 0.87A 5zv2B-4ml1A:
undetectable		 5zv2B-4ml1A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mt0 MTRE PROTEIN

(Neisseria
gonorrhoeae) 		PF02321
(OEP) 		3 TYR A 452
LEU A 163
ASP A 283
 None
 0.87A 5zv2B-4mt0A:
undetectable		 5zv2B-4mt0A:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p2k EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		3 TYR A 694
LEU A 746
ASP A 757
 None
 0.58A 5zv2B-4p2kA:
31.5		 5zv2B-4p2kA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9z HUMAN PROTEIN KINASE
C THETA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		3 TYR A 460
LEU A 511
ASP A 522
 None
PZW  A 801 (-4.8A)
PZW  A 801 (-3.2A)
 0.60A 5zv2B-4q9zA:
17.6		 5zv2B-4q9zA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qpy COMPLEMENT C1Q-LIKE
PROTEIN 2

(Mus musculus) 		PF00386
(C1q) 		3 TYR A  22
LEU A  25
ASP A  28
 None
 0.80A 5zv2B-4qpyA:
undetectable		 5zv2B-4qpyA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qsl PYRUVATE CARBOXYLASE

(Listeria
monocytogenes) 		no annotation 3 TYR H 783
LEU H 794
ASP H 536
 None
 0.49A 5zv2B-4qslH:
undetectable		 5zv2B-4qslH:
5.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3m 2-DEHYDROPANTOATE
2-REDUCTASE

(Staphylococcus
aureus) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		3 TYR A 272
LEU A 204
ASP A 223
 None
 0.79A 5zv2B-4s3mA:
undetectable		 5zv2B-4s3mA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE

(Methylovorus
sp. MP688) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		3 TYR A   8
LEU A  20
ASP A 500
 None
None
FAD  A 700 (-4.3A)
 0.76A 5zv2B-4udrA:
undetectable		 5zv2B-4udrA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4um8 INTEGRIN BETA-6

(Homo sapiens) 		PF00362
(Integrin_beta)
PF17205
(PSI_integrin) 		3 TYR B 120
LEU B 155
ASP B 202
 None
 0.79A 5zv2B-4um8B:
undetectable		 5zv2B-4um8B:
7.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upi SULFATASE FAMILY
PROTEIN

(Ruegeria
pomeroyi) 		PF00884
(Sulfatase) 		3 TYR A 509
LEU A 516
ASP A 520
 None
 0.87A 5zv2B-4upiA:
undetectable		 5zv2B-4upiA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wfs TRNA-DIHYDROURIDINE(
20) SYNTHASE
[NAD(P)+]-LIKE

(Homo sapiens) 		PF01207
(Dus) 		3 TYR A 270
LEU A  25
ASP A  64
 None
 0.81A 5zv2B-4wfsA:
undetectable		 5zv2B-4wfsA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjl INACTIVE DIPEPTIDYL
PEPTIDASE 10

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		3 TYR A 767
LEU A 774
ASP A 585
 None
 0.82A 5zv2B-4wjlA:
undetectable		 5zv2B-4wjlA:
8.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x81 MYCINAMICIN III
3''-O-METHYLTRANSFER
ASE

(Micromonospora
griseorubida) 		PF05711
(TylF) 		3 TYR A  49
LEU A 143
ASP A 113
 MVI  A 305 ( 4.3A)
SAH  A 301 (-4.4A)
SAH  A 301 (-2.7A)
 0.88A 5zv2B-4x81A:
undetectable		 5zv2B-4x81A:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgm MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 3

(Homo sapiens) 		PF16953
(PRORP) 		3 TYR A 307
LEU A 279
ASP A 561
 None
 0.61A 5zv2B-4xgmA:
undetectable		 5zv2B-4xgmA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		3 TYR A 476
LEU A 528
ASP A 539
 None
 0.60A 5zv2B-4xi2A:
30.0		 5zv2B-4xi2A:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z5p CYTOCHROME P450
HYDROXYLASE

(Streptomyces
atroolivaceus) 		PF00067
(p450) 		3 TYR A 347
LEU A 339
ASP A  52
 None
 0.76A 5zv2B-4z5pA:
undetectable		 5zv2B-4z5pA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a21 PORTAL PROTEIN

(Bacillus phage
SPP1) 		PF05133
(Phage_prot_Gp6) 		3 TYR A 208
LEU A 181
ASP A  39
 None
 0.79A 5zv2B-5a21A:
undetectable		 5zv2B-5a21A:
12.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 TYR A 563
LEU A 630
ASP A 641
 38O  A1769 (-4.2A)
38O  A1769 (-4.6A)
38O  A1769 (-4.0A)
 0.46A 5zv2B-5a46A:
16.3		 5zv2B-5a46A:
78.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aff RIBOSOMAL PROTEIN
L11
SYMPORTIN 1

(Chaetomium
thermophilum) 		PF00281
(Ribosomal_L5)
PF00673
(Ribosomal_L5_C)
no annotation 		3 TYR C 117
LEU A 431
ASP A 434
 None
 0.72A 5zv2B-5affC:
undetectable		 5zv2B-5affC:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		3 TYR A 134
LEU A 185
ASP A 196
 5RC  A4000 (-4.5A)
None
5RC  A4000 (-3.6A)
 0.89A 5zv2B-5es1A:
22.8		 5zv2B-5es1A:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gza PROTEIN O-MANNOSE
KINASE

(Danio rerio) 		PF07714
(Pkinase_Tyr) 		3 TYR A 183
LEU A 210
ASP A 159
 None
 0.75A 5zv2B-5gzaA:
18.6		 5zv2B-5gzaA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idn CYCLIN-DEPENDENT
KINASE 8

(Homo sapiens) 		PF00069
(Pkinase) 		3 TYR A  99
LEU A 158
ASP A 173
 6A7  A 401 (-4.9A)
6A7  A 401 (-4.8A)
FMT  A 403 ( 3.3A)
 0.80A 5zv2B-5idnA:
21.5		 5zv2B-5idnA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbk BETA-GLUCOSIDASE

(Trichoderma
harzianum) 		PF00232
(Glyco_hydro_1) 		3 TYR A 263
LEU A 271
ASP A 314
 None
 0.83A 5zv2B-5jbkA:
undetectable		 5zv2B-5jbkA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbo BETA-GLUCOSIDASE

(Trichoderma
harzianum) 		PF00232
(Glyco_hydro_1) 		3 TYR A 280
LEU A 288
ASP A 332
 None
 0.87A 5zv2B-5jboA:
undetectable		 5zv2B-5jboA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jd4 LAE6

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		3 TYR A 222
LEU A 121
ASP A  37
 None
 0.85A 5zv2B-5jd4A:
undetectable		 5zv2B-5jd4A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jpn COMPLEMENT C4-A

(Homo sapiens) 		PF00207
(A2M)
PF01821
(ANATO)
PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl) 		3 TYR B 977
LEU B1362
ASP B 965
 PBM  B1515 ( 4.9A)
None
None
 0.85A 5zv2B-5jpnB:
undetectable		 5zv2B-5jpnB:
7.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkk MULTIDRUG RESISTANCE
ABC TRANSPORTER
ATP-BINDING AND
PERMEASE PROTEIN

(Thermus
thermophilus) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		3 TYR B 231
LEU B 238
ASP B 184
 None
 0.86A 5zv2B-5mkkB:
undetectable		 5zv2B-5mkkB:
9.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ofn DNA PRIMASE SMALL
SUBUNIT PRIS

(Sulfolobus
solfataricus) 		no annotation 3 TYR A 138
LEU A 110
ASP A 105
 None
 0.88A 5zv2B-5ofnA:
undetectable		 5zv2B-5ofnA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tla UBIQUITIN-LIKE
PROTEIN ISG15

(Mus musculus) 		PF00240
(ubiquitin) 		3 TYR A  94
LEU A 122
ASP A 131
 None
 0.79A 5zv2B-5tlaA:
undetectable		 5zv2B-5tlaA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		3 TYR A 171
LEU A 221
ASP A 232
 None
 0.67A 5zv2B-5u7qA:
18.9		 5zv2B-5u7qA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ub6 PHOSPHATE-BINDING
PROTEIN

(Xanthomonas
citri) 		no annotation 3 TYR A  47
LEU A  54
ASP A  90
 None
 0.89A 5zv2B-5ub6A:
undetectable		 5zv2B-5ub6A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vi6 HISTONE DEACETYLASE
8

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		3 TYR A 306
LEU A 179
ASP A 233
 EDO  A 407 ( 3.3A)
None
None
 0.71A 5zv2B-5vi6A:
undetectable		 5zv2B-5vi6A:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdh KINESIN-LIKE PROTEIN
KIFC1

(Homo sapiens) 		PF00225
(Kinesin) 		3 TYR A 402
LEU A 394
ASP A 375
 None
 0.82A 5zv2B-5wdhA:
undetectable		 5zv2B-5wdhA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bu3 BETA-LACTAMASE

(Escherichia
coli) 		no annotation 3 TYR A  60
LEU A  36
ASP A 277
 None
None
SO4  A 303 (-4.2A)
 0.88A 5zv2B-6bu3A:
undetectable		 5zv2B-6bu3A:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fd7 -

(-) 		no annotation 3 TYR A 143
LEU A 136
ASP A 161
 None
 0.87A 5zv2B-6fd7A:
undetectable		 5zv2B-6fd7A:
undetectable