SIMILAR PATTERNS OF AMINO ACIDS FOR 5ZV2_B_LEVB801

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 VAL A 209
ALA A 220
LYS A 222
GLU A 236
MET A 240
GLY A 272
 None
 0.62A 5zv2B-1k9aA:
26.0		 5zv2B-1k9aA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		9 LEU A 267
GLY A 268
VAL A 275
ALA A 288
LYS A 290
GLU A 305
MET A 309
GLY A 340
ALA A 399
 P16  A   2 ( 4.2A)
P16  A   2 ( 4.3A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 (-3.4A)
P16  A   2 (-3.5A)
 0.50A 5zv2B-1opkA:
31.3		 5zv2B-1opkA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		6 LEU A 164
VAL A 172
ALA A 185
LYS A 187
GLU A 202
ALA A 549
 ADP  A 810 ( 4.3A)
ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
ADP  A 810 (-3.1A)
None
None
 0.70A 5zv2B-1q8yA:
20.6		 5zv2B-1q8yA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
GLY A 617
VAL A 624
ALA A 642
LYS A 644
GLU A 661
GLY A 697
 None
 1.01A 5zv2B-1rjbA:
32.3		 5zv2B-1rjbA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 595
VAL A 603
ALA A 621
LYS A 623
GLU A 640
GLY A 676
 STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 ( 3.8A)
 0.48A 5zv2B-1t46A:
28.8		 5zv2B-1t46A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 344
VAL A 352
ALA A 367
LYS A 369
GLU A 386
MET A 390
ALA A 417
GLY A 420
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
STU  A 100 ( 4.7A)
None
None
STU  A 100 (-3.7A)
STU  A 100 (-3.5A)
 0.68A 5zv2B-1u59A:
30.3		 5zv2B-1u59A:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  55
GLY A  90
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
None
None
 0.49A 5zv2B-1zltA:
11.0		 5zv2B-1zltA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  19
VAL A  27
ALA A  40
LYS A  42
GLU A  64
GLY A  99
 None
None
GOL  A3001 (-3.5A)
None
None
None
 0.58A 5zv2B-2a2aA:
22.4		 5zv2B-2a2aA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buj SERINE/THREONINE-PRO
TEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  26
VAL A  34
ALA A  47
LYS A  49
GLU A  65
GLY A 104
 STU  A1301 (-4.2A)
STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
STU  A1301 ( 4.0A)
None
STU  A1301 ( 4.0A)
 0.68A 5zv2B-2bujA:
22.7		 5zv2B-2bujA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU X  17
VAL X  25
ALA X  37
LYS X  39
GLU X  54
MET X  58
GLY X  88
ALA X 147
 STU  X 902 (-3.8A)
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
None
STU  X 902 (-3.5A)
STU  X 902 ( 4.1A)
 0.63A 5zv2B-2dq7X:
30.3		 5zv2B-2dq7X:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A 162
VAL A 170
ALA A 184
LYS A 186
GLU A 201
GLY A 240
ALA A 319
 None
 0.86A 5zv2B-2eu9A:
21.0		 5zv2B-2eu9A:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hak SERINE/THREONINE-PRO
TEIN KINASE MARK1

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		7 VAL A  67
ALA A  80
LYS A  82
MET A 104
ALA A 132
GLY A 135
ALA A 192
 None
 1.01A 5zv2B-2hakA:
13.6		 5zv2B-2hakA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 251
VAL A 259
ALA A 271
LYS A 273
GLU A 288
MET A 292
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
 0.73A 5zv2B-2hk5A:
25.0		 5zv2B-2hk5A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 248
VAL A 256
ALA A 269
GLU A 286
MET A 290
GLY A 321
ALA A 380
 GIN  A 600 ( 4.6A)
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.2A)
None
GIN  A 600 (-3.1A)
 0.65A 5zv2B-2hz0A:
29.8		 5zv2B-2hz0A:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 248
VAL A 256
ALA A 269
LYS A 271
GLU A 286
GLY A 321
ALA A 380
 GIN  A 600 ( 4.6A)
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.6A)
None
GIN  A 600 (-3.1A)
 0.54A 5zv2B-2hz0A:
29.8		 5zv2B-2hz0A:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		6 VAL A 436
ALA A 452
LYS A 454
GLU A 471
MET A 475
GLY A 505
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 4.6A)
None
4ST  A1687 (-3.2A)
 0.50A 5zv2B-2j0jA:
32.6		 5zv2B-2j0jA:
7.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 251
PHE A 383
VAL A 259
ALA A 271
LYS A 273
GLU A 288
MET A 292
GLY A 322
ALA A 381
 None
1N8  A 501 ( 4.3A)
None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.5A)
1N8  A 501 ( 3.3A)
 0.88A 5zv2B-2og8A:
30.1		 5zv2B-2og8A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 588
VAL A 596
ALA A 614
GLU A 633
MET A 637
GLY A 669
 None
 0.57A 5zv2B-2ogvA:
32.2		 5zv2B-2ogvA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		6 LEU A  25
VAL A  33
ALA A  46
LYS A  48
GLU A  73
GLY A 109
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
None
None
 0.65A 5zv2B-2phkA:
22.2		 5zv2B-2phkA:
14.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 487
GLY A 488
VAL A 495
ALA A 515
GLU A 534
MET A 538
VAL A 564
ALA A 567
GLY A 570
ALA A 643
 None
 0.62A 5zv2B-2psqA:
36.7		 5zv2B-2psqA:
45.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  19
VAL A  27
ALA A  40
LYS A  42
GLU A  64
GLY A  99
 ADP  A1303 ( 3.9A)
ADP  A1303 (-4.0A)
ADP  A1303 (-3.5A)
ADP  A1303 (-2.7A)
ADP  A1303 ( 4.8A)
None
 0.50A 5zv2B-2w4kA:
22.7		 5zv2B-2w4kA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yab DEATH-ASSOCIATED
PROTEIN KINASE 2

(Mus musculus) 		PF00069
(Pkinase) 		6 LEU A  19
VAL A  27
ALA A  40
LYS A  42
GLU A  64
GLY A  99
 AMP  A1302 (-3.7A)
AMP  A1302 (-4.2A)
AMP  A1302 (-3.6A)
AMP  A1302 (-2.8A)
None
None
 0.51A 5zv2B-2yabA:
22.6		 5zv2B-2yabA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8c INSULIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A1002
VAL A1010
ALA A1028
LYS A1030
GLU A1047
MET A1051
 S91  A   1 ( 4.1A)
S91  A   1 ( 4.9A)
S91  A   1 (-3.2A)
S91  A   1 ( 4.2A)
None
None
 0.67A 5zv2B-2z8cA:
30.5		 5zv2B-2z8cA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 LEU A 253
VAL A 261
ALA A 273
LYS A 275
GLU A 290
MET A 294
 None
 0.64A 5zv2B-2zv7A:
30.7		 5zv2B-2zv7A:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  97
VAL A 105
ALA A 121
LYS A 123
GLU A 143
GLY A 178
 STU  A 400 (-3.8A)
STU  A 400 (-4.9A)
STU  A 400 (-3.1A)
STU  A 400 ( 4.3A)
STU  A 400 ( 4.3A)
STU  A 400 ( 4.4A)
 0.63A 5zv2B-3a62A:
21.8		 5zv2B-3a62A:
13.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 487
GLY A 488
VAL A 495
ALA A 515
GLU A 534
MET A 538
VAL A 564
 M33  A1996 (-4.0A)
M33  A1996 ( 3.8A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
None
None
 1.07A 5zv2B-3b2tA:
29.0		 5zv2B-3b2tA:
75.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 487
GLY A 488
VAL A 495
ALA A 515
MET A 538
VAL A 564
ALA A 567
ALA A 643
 M33  A1996 (-4.0A)
M33  A1996 ( 3.8A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
None
M33  A1996 (-3.8A)
None
 0.94A 5zv2B-3b2tA:
29.0		 5zv2B-3b2tA:
75.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 487
VAL A 495
ALA A 515
LYS A 517
GLU A 534
MET A 538
VAL A 564
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
None
None
None
 0.80A 5zv2B-3b2tA:
29.0		 5zv2B-3b2tA:
75.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 487
VAL A 495
ALA A 515
LYS A 517
MET A 538
VAL A 564
ALA A 567
GLY A 570
ALA A 643
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
None
None
M33  A1996 (-3.8A)
M33  A1996 ( 4.8A)
None
 0.67A 5zv2B-3b2tA:
29.0		 5zv2B-3b2tA:
75.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 487
PHE A 489
VAL A 492
ALA A 512
MET A 535
VAL A 561
ALA A 640
 None
C4F  A   1 (-3.7A)
None
C4F  A   1 (-3.3A)
C4F  A   1 ( 3.7A)
C4F  A   1 ( 4.8A)
C4F  A   1 (-3.6A)
 1.37A 5zv2B-3c4fA:
42.4		 5zv2B-3c4fA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		11 LEU A 484
GLY A 485
PHE A 489
VAL A 492
ALA A 512
GLU A 531
MET A 535
VAL A 561
ALA A 564
GLY A 567
ALA A 640
 C4F  A   1 ( 3.9A)
C4F  A   1 ( 4.5A)
C4F  A   1 (-3.7A)
None
C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
C4F  A   1 ( 4.8A)
C4F  A   1 (-3.5A)
None
C4F  A   1 (-3.6A)
 0.61A 5zv2B-3c4fA:
42.4		 5zv2B-3c4fA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		11 LEU A 484
GLY A 485
PHE A 489
VAL A 492
ALA A 512
LYS A 514
GLU A 531
MET A 535
VAL A 561
ALA A 564
GLY A 567
 C4F  A   1 ( 3.9A)
C4F  A   1 ( 4.5A)
C4F  A   1 (-3.7A)
None
C4F  A   1 (-3.3A)
None
None
C4F  A   1 ( 3.7A)
C4F  A   1 ( 4.8A)
C4F  A   1 (-3.5A)
None
 0.79A 5zv2B-3c4fA:
42.4		 5zv2B-3c4fA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 209
ALA A 220
LYS A 222
GLU A 236
MET A 240
GLY A 272
 None
 0.62A 5zv2B-3d7uA:
31.0		 5zv2B-3d7uA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		6 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  50
MET A  54
 DRK  A 384 (-3.8A)
None
DRK  A 384 (-3.5A)
None
None
None
 0.53A 5zv2B-3eb0A:
20.4		 5zv2B-3eb0A:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fe3 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 3

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		7 VAL A  70
ALA A  83
LYS A  85
MET A 107
ALA A 135
GLY A 138
ALA A 195
 None
 0.88A 5zv2B-3fe3A:
22.2		 5zv2B-3fe3A:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 833
VAL A 841
ALA A 859
LYS A 861
GLU A 878
VAL A 909
GLY A 915
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
8ST  A2001 (-3.7A)
8ST  A2001 (-4.1A)
None
 0.31A 5zv2B-3hngA:
33.5		 5zv2B-3hngA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		7 VAL A  67
ALA A  80
LYS A  82
MET A 104
ALA A 132
GLY A 135
ALA A 192
 None
 0.71A 5zv2B-3iecA:
22.5		 5zv2B-3iecA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  39
VAL A  47
ALA A  60
GLU A  80
ALA A 113
GLY A 116
 QUE  A   1 ( 3.8A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-3.1A)
QUE  A   1 (-3.9A)
None
 0.63A 5zv2B-3lm5A:
23.9		 5zv2B-3lm5A:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  39
VAL A  47
ALA A  60
LYS A  62
ALA A 113
GLY A 116
 QUE  A   1 ( 3.8A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.1A)
QUE  A   1 (-3.9A)
None
 0.58A 5zv2B-3lm5A:
23.9		 5zv2B-3lm5A:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  49
VAL A  57
ALA A  70
LYS A  72
GLU A  91
GLY A 126
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
None
 0.36A 5zv2B-3mvjA:
20.5		 5zv2B-3mvjA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  88
VAL A  96
ALA A 109
GLU A 130
MET A 134
ALA A 162
GLY A 165
 JOZ  A 361 (-4.1A)
JOZ  A 361 ( 4.7A)
JOZ  A 361 (-3.4A)
SO4  A   5 (-3.1A)
None
JOZ  A 361 (-3.8A)
None
 0.57A 5zv2B-3nuuA:
23.2		 5zv2B-3nuuA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  88
VAL A  96
ALA A 109
LYS A 111
GLU A 130
ALA A 162
GLY A 165
 JOZ  A 361 (-4.1A)
JOZ  A 361 ( 4.7A)
JOZ  A 361 (-3.4A)
SO4  A   5 (-2.8A)
SO4  A   5 (-3.1A)
JOZ  A 361 (-3.8A)
None
 0.46A 5zv2B-3nuuA:
23.2		 5zv2B-3nuuA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		6 LEU A 192
VAL A 200
ALA A 213
LYS A 215
GLU A 234
GLY A 269
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
 0.71A 5zv2B-3nyoA:
21.5		 5zv2B-3nyoA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 LEU A  63
VAL A  71
ALA A  84
LYS A  86
GLU A 115
GLY A 150
 ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
None
 0.63A 5zv2B-3q5iA:
19.8		 5zv2B-3q5iA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfv CDC42BPB PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  90
ALA A 103
LYS A 105
GLU A 124
GLY A 159
ALA A 217
 NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
EDO  A 417 (-3.5A)
EDO  A 417 (-4.0A)
None
NM7  A 416 ( 4.5A)
 0.66A 5zv2B-3qfvA:
3.3		 5zv2B-3qfvA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3she MAP KINASE-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  50
VAL A  58
ALA A  71
LYS A  73
GLU A  84
GLY A 124
 I85  A 350 (-3.7A)
I85  A 350 (-4.9A)
I85  A 350 (-3.3A)
I85  A 350 (-2.8A)
None
I85  A 350 (-3.0A)
 0.65A 5zv2B-3sheA:
18.9		 5zv2B-3sheA:
11.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 484
VAL A 492
ALA A 512
LYS A 514
GLU A 531
MET A 535
VAL A 561
ALA A 564
GLY A 567
ALA A 640
 07J  A   1 ( 4.3A)
07J  A   1 (-4.0A)
07J  A   1 (-3.5A)
07J  A   1 (-4.5A)
07J  A   1 (-3.8A)
07J  A   1 (-3.8A)
07J  A   1 (-4.7A)
07J  A   1 (-3.8A)
07J  A   1 (-3.7A)
07J  A   1 (-3.2A)
 0.37A 5zv2B-3tt0A:
40.2		 5zv2B-3tt0A:
59.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 LEU A 361
VAL A 369
ALA A 382
LYS A 384
GLU A 403
GLY A 439
ALA A 496
 07U  A   1 ( 4.8A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 (-3.0A)
07U  A   1 ( 4.8A)
None
07U  A   1 ( 4.0A)
 0.70A 5zv2B-3txoA:
18.6		 5zv2B-3txoA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 840
VAL A 848
ALA A 866
LYS A 868
GLU A 885
VAL A 916
GLY A 922
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
None
4TT  A2001 (-3.7A)
 0.41A 5zv2B-3vidA:
34.4		 5zv2B-3vidA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w18 AURORA KINASE A

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A 139
VAL A 147
ALA A 160
LYS A 162
ALA A 213
GLY A 216
ALA A 273
 N13  A 501 (-3.7A)
N13  A 501 ( 4.7A)
N13  A 501 ( 4.1A)
N13  A 501 (-2.9A)
N13  A 501 (-3.7A)
N13  A 501 (-3.5A)
N13  A 501 ( 3.8A)
 0.66A 5zv2B-3w18A:
22.3		 5zv2B-3w18A:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 840
GLY A 841
VAL A 848
ALA A 866
LYS A 868
GLU A 885
VAL A 916
GLY A 922
 LEV  A1201 ( 3.8A)
LEV  A1201 (-3.1A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
None
LEV  A1201 (-3.7A)
LEV  A1201 ( 4.6A)
LEV  A1201 (-3.6A)
 0.57A 5zv2B-3wzdA:
35.6		 5zv2B-3wzdA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4af3 AURORA KINASE B

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  83
GLY A  84
VAL A  91
ALA A 104
ALA A 157
GLY A 160
ALA A 217
 VX6  A 500 (-3.8A)
VX6  A 500 ( 4.1A)
VX6  A 500 ( 4.8A)
VX6  A 500 (-3.4A)
VX6  A 500 (-3.7A)
VX6  A 500 (-3.3A)
VX6  A 500 ( 4.2A)
 0.79A 5zv2B-4af3A:
20.1		 5zv2B-4af3A:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4af3 AURORA KINASE B

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  83
VAL A  91
ALA A 104
LYS A 106
ALA A 157
GLY A 160
ALA A 217
 VX6  A 500 (-3.8A)
VX6  A 500 ( 4.8A)
VX6  A 500 (-3.4A)
VX6  A 500 (-3.3A)
VX6  A 500 (-3.7A)
VX6  A 500 (-3.3A)
VX6  A 500 ( 4.2A)
 0.80A 5zv2B-4af3A:
20.1		 5zv2B-4af3A:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 840
PHE A1047
VAL A 848
ALA A 866
GLU A 885
VAL A 916
GLY A 922
 B49  A2000 (-3.7A)
B49  A2000 (-4.0A)
None
B49  A2000 (-3.5A)
None
B49  A2000 (-4.8A)
B49  A2000 ( 3.7A)
 0.83A 5zv2B-4agdA:
34.0		 5zv2B-4agdA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 560
GLY A 561
PHE A 565
VAL A 568
ALA A 586
LYS A 588
GLY A 639
 LTI  A1839 ( 4.2A)
LTI  A1839 ( 4.3A)
LTI  A1839 (-3.5A)
None
LTI  A1839 (-3.3A)
None
LTI  A1839 (-3.4A)
 0.69A 5zv2B-4at3A:
32.1		 5zv2B-4at3A:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 VAL A  91
ALA A 104
LYS A 106
GLU A 125
GLY A 160
ALA A 218
 None
EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
EDO  A1419 (-3.0A)
None
None
 0.42A 5zv2B-4aw2A:
19.0		 5zv2B-4aw2A:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		7 LEU A 246
VAL A 254
ALA A 267
LYS A 269
GLU A 288
ALA A 321
GLY A 324
 None
 0.49A 5zv2B-4c0tA:
22.7		 5zv2B-4c0tA:
5.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		6 LEU A  22
VAL A  30
ALA A  43
LYS A  45
GLY A  99
ALA A 156
 STU  A1550 (-4.3A)
None
STU  A1550 (-3.1A)
STU  A1550 (-3.6A)
STU  A1550 (-3.4A)
STU  A1550 ( 3.8A)
 0.71A 5zv2B-4cfhA:
23.1		 5zv2B-4cfhA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 616
PHE A 785
VAL A 624
ALA A 653
LYS A 655
GLU A 672
MET A 676
GLY A 707
ALA A 783
 None
DI1  A1000 (-4.5A)
DI1  A1000 (-4.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.9A)
DI1  A1000 (-3.8A)
DI1  A1000 (-3.6A)
None
DI1  A1000 (-3.7A)
 0.90A 5zv2B-4ckrA:
29.8		 5zv2B-4ckrA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		8 LEU A 663
VAL A 671
ALA A 684
LYS A 686
GLU A 705
ALA A 740
GLY A 743
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
AGS  A1985 (-3.9A)
None
AGS  A1985 ( 4.5A)
 0.64A 5zv2B-4crsA:
16.1		 5zv2B-4crsA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  55
GLY A  92
 BX7  A 401 (-3.7A)
BX7  A 401 (-4.4A)
BX7  A 401 (-3.4A)
BX7  A 401 ( 4.0A)
None
BX7  A 401 (-3.5A)
 0.34A 5zv2B-4eutA:
19.1		 5zv2B-4eutA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  55
GLY A  92
 BX7  A 401 (-3.9A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.4A)
BX7  A 401 (-3.5A)
None
BX7  A 401 (-3.3A)
 0.29A 5zv2B-4euuA:
21.1		 5zv2B-4euuA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 377
VAL A 385
ALA A 400
LYS A 402
GLU A 420
MET A 424
ALA A 451
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
None
None
0SB  A 701 (-4.0A)
 0.79A 5zv2B-4f4pA:
29.2		 5zv2B-4f4pA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 LEU A 514
VAL A 522
ALA A 538
LYS A 540
GLY A 599
ALA A 662
 0T8  A 901 (-3.6A)
0T8  A 901 ( 4.4A)
0T8  A 901 (-3.2A)
0T8  A 901 (-3.5A)
0T8  A 901 ( 3.8A)
0T8  A 901 ( 4.5A)
 0.71A 5zv2B-4feqA:
25.4		 5zv2B-4feqA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gv1 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 LEU A 156
VAL A 164
ALA A 177
LYS A 179
GLU A 198
ALA A 230
GLY A 233
 0XZ  A 501 ( 4.1A)
0XZ  A 501 (-4.5A)
0XZ  A 501 (-3.3A)
GOL  A 503 ( 2.8A)
GOL  A 503 (-3.6A)
0XZ  A 501 (-3.7A)
None
 0.65A 5zv2B-4gv1A:
20.8		 5zv2B-4gv1A:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 828
VAL A 836
ALA A 853
LYS A 855
GLU A 871
GLY A 908
ALA A 966
 19S  A1201 (-3.9A)
19S  A1201 (-4.4A)
19S  A1201 (-3.3A)
19S  A1201 (-3.5A)
None
19S  A1201 ( 3.8A)
19S  A1201 ( 4.1A)
 0.50A 5zv2B-4hviA:
24.1		 5zv2B-4hviA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		6 LEU A 132
VAL A 140
ALA A 156
LYS A 158
ALA A 208
GLY A 211
 None
 0.63A 5zv2B-4hzsA:
22.0		 5zv2B-4hzsA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 132
VAL A 140
ALA A 156
LYS A 158
ALA A 208
GLY A 211
 1G0  A 401 ( 4.5A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 (-3.8A)
1G0  A 401 ( 4.5A)
 0.71A 5zv2B-4id7A:
29.5		 5zv2B-4id7A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  18
GLY A  19
VAL A  26
ALA A  39
LYS A  41
GLY A  95
ALA A 153
 631  A 301 (-3.4A)
631  A 301 (-3.6A)
631  A 301 (-4.6A)
631  A 301 (-3.3A)
631  A 301 (-2.7A)
631  A 301 ( 3.7A)
631  A 301 (-3.4A)
 0.80A 5zv2B-4jxfA:
20.2		 5zv2B-4jxfA:
14.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 478
GLY A 479
ALA A 506
ALA A 558
GLY A 561
ALA A 634
 ACP  A 801 (-3.8A)
ACP  A 801 (-3.4A)
ACP  A 801 (-3.3A)
ACP  A 801 (-3.7A)
ACP  A 801 ( 4.6A)
None
 0.64A 5zv2B-4k33A:
29.4		 5zv2B-4k33A:
66.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 478
VAL A 486
ALA A 506
LYS A 508
GLU A 525
MET A 529
VAL A 555
ALA A 558
GLY A 561
ALA A 634
 ACP  A 801 (-3.8A)
ACP  A 801 (-4.2A)
ACP  A 801 (-3.3A)
ACP  A 801 (-2.7A)
ACP  A 801 ( 4.8A)
None
ACP  A 801 (-4.7A)
ACP  A 801 (-3.7A)
ACP  A 801 ( 4.6A)
None
 0.73A 5zv2B-4k33A:
29.4		 5zv2B-4k33A:
66.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A  50
ALA A  61
LYS A  63
GLU A  77
ALA A 107
GLY A 110
 1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
None
None
1UL  A 501 (-3.6A)
1UL  A 501 ( 3.7A)
 0.74A 5zv2B-4l52A:
27.0		 5zv2B-4l52A:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 LEU A  78
VAL A  86
ALA A  99
LYS A 101
GLU A 117
GLY A 151
 STU  A 601 ( 4.0A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-3.9A)
None
STU  A 601 (-3.4A)
 0.73A 5zv2B-4mvfA:
19.1		 5zv2B-4mvfA:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL B  38
ALA B  51
LYS B  53
GLU B  70
GLY B 105
ALA B 161
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
None
None
None
 0.50A 5zv2B-4o27B:
24.7		 5zv2B-4o27B:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  46
VAL A  54
ALA A  67
LYS A  69
GLU A  85
GLY A 128
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
None
SIN  A 401 (-3.5A)
 0.55A 5zv2B-4o38A:
20.3		 5zv2B-4o38A:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9z HUMAN PROTEIN KINASE
C THETA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 LEU A 386
VAL A 394
ALA A 407
LYS A 409
GLU A 428
GLY A 464
ALA A 521
 PZW  A 801 (-3.9A)
PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
None
None
None
PZW  A 801 ( 4.6A)
 0.71A 5zv2B-4q9zA:
17.6		 5zv2B-4q9zA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ra4 PROTEIN KINASE C

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 LEU A 345
VAL A 353
ALA A 366
LYS A 368
GLU A 387
GLY A 423
ALA A 480
 3KZ  A 701 ( 4.1A)
3KZ  A 701 (-3.9A)
3KZ  A 701 (-3.4A)
3KZ  A 701 ( 4.7A)
None
None
3KZ  A 701 ( 4.8A)
 0.92A 5zv2B-4ra4A:
20.7		 5zv2B-4ra4A:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
PHE A 830
VAL A 624
ALA A 642
LYS A 644
GLU A 661
GLY A 697
 P30  A1001 (-3.8A)
P30  A1001 (-3.9A)
None
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 (-3.4A)
 0.74A 5zv2B-4rt7A:
29.0		 5zv2B-4rt7A:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		6 LEU A 192
VAL A 200
ALA A 213
LYS A 215
GLU A 234
GLY A 268
 SGV  A 601 (-4.1A)
SGV  A 601 ( 4.6A)
SGV  A 601 (-3.3A)
SGV  A 601 ( 4.2A)
None
None
 0.65A 5zv2B-4tnbA:
17.1		 5zv2B-4tnbA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		7 LEU A  14
VAL A  22
ALA A  35
LYS A  37
GLU A  52
MET A  56
ALA A 146
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
None
 0.80A 5zv2B-4ueuA:
30.5		 5zv2B-4ueuA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		7 LEU A  14
VAL A  22
ALA A  35
LYS A  37
MET A  56
GLY A  87
ALA A 146
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-3.5A)
None
 0.91A 5zv2B-4ueuA:
30.5		 5zv2B-4ueuA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase)
PF00226
(DnaJ) 		6 LEU A 104
VAL A 112
ALA A 125
LYS A 127
GLU A 146
GLY A 181
 ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ATP  A 501 (-2.6A)
None
None
 0.41A 5zv2B-4wb7A:
20.5		 5zv2B-4wb7A:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  52
VAL A  60
ALA A  72
LYS A  74
GLU A  90
MET A  94
GLY A 132
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
None
None
KSA  A 405 (-3.5A)
 0.92A 5zv2B-4wsqA:
22.1		 5zv2B-4wsqA:
14.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 473
VAL A 481
ALA A 501
LYS A 503
GLU A 520
MET A 524
VAL A 550
ALA A 553
GLY A 556
ALA A 629
 40M  A1002 ( 4.6A)
40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-4.0A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
40M  A1002 (-4.7A)
40M  A1002 (-3.7A)
40M  A1002 ( 3.7A)
40M  A1002 (-3.0A)
 0.55A 5zv2B-4xcuA:
38.0		 5zv2B-4xcuA:
65.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 617
PHE A 830
ALA A 642
LYS A 644
GLU A 661
MET A 665
GLY A 697
 None
P30  A1001 ( 4.1A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
P30  A1001 (-4.4A)
P30  A1001 (-3.5A)
 1.18A 5zv2B-4xufA:
32.5		 5zv2B-4xufA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
GLY A 617
PHE A 830
ALA A 642
LYS A 644
GLU A 661
GLY A 697
 P30  A1001 (-4.0A)
None
P30  A1001 ( 4.1A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
P30  A1001 (-3.5A)
 1.17A 5zv2B-4xufA:
32.5		 5zv2B-4xufA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
PHE A 830
VAL A 624
ALA A 642
LYS A 644
GLU A 661
GLY A 697
 P30  A1001 (-4.0A)
P30  A1001 ( 4.1A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
P30  A1001 (-3.5A)
 0.81A 5zv2B-4xufA:
32.5		 5zv2B-4xufA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 PHE A 830
VAL A 624
ALA A 642
LYS A 644
GLU A 661
MET A 665
GLY A 697
 P30  A1001 ( 4.1A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
P30  A1001 (-4.4A)
P30  A1001 (-3.5A)
 0.90A 5zv2B-4xufA:
32.5		 5zv2B-4xufA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 477
ALA A 488
LYS A 490
GLU A 509
GLY A 545
ALA A 605
 None
4CV  A 801 (-3.5A)
4CV  A 801 (-3.9A)
None
4CV  A 801 ( 4.0A)
4CV  A 801 ( 3.9A)
 0.64A 5zv2B-4yffA:
15.1		 5zv2B-4yffA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 LEU A  34
VAL A  42
ALA A  55
LYS A  57
GLU A  76
GLY A 111
 ADP  A 506 ( 3.8A)
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
None
 0.49A 5zv2B-4ysjA:
22.5		 5zv2B-4ysjA:
11.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 484
GLY A 485
ALA A 512
MET A 535
VAL A 561
ALA A 564
ALA A 640
 38O  A1769 (-3.2A)
38O  A1769 ( 4.7A)
38O  A1769 (-3.6A)
EDO  A1766 (-3.5A)
38O  A1769 (-4.3A)
38O  A1769 (-3.9A)
EDO  A1766 ( 4.4A)
 1.07A 5zv2B-5a46A:
40.7		 5zv2B-5a46A:
78.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 484
VAL A 492
ALA A 512
LYS A 514
GLU A 531
MET A 535
VAL A 561
ALA A 564
GLY A 567
ALA A 640
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
38O  A1769 (-4.3A)
38O  A1769 (-3.9A)
38O  A1769 (-3.4A)
EDO  A1766 ( 4.4A)
 0.52A 5zv2B-5a46A:
40.7		 5zv2B-5a46A:
78.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		7 VAL A  70
ALA A  83
LYS A  85
GLU A 103
ALA A 135
GLY A 138
ALA A 195
 5RC  A4000 (-4.6A)
5RC  A4000 (-3.6A)
5RC  A4000 (-2.8A)
None
5RC  A4000 (-3.7A)
5RC  A4000 (-3.3A)
5RC  A4000 ( 3.9A)
 0.76A 5zv2B-5es1A:
22.8		 5zv2B-5es1A:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyk AURORA KINASE B-A

(Xenopus laevis) 		PF00069
(Pkinase) 		7 LEU A  99
VAL A 107
ALA A 120
LYS A 122
ALA A 173
GLY A 176
ALA A 233
 5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-2.6A)
5U5  A 401 (-3.9A)
5U5  A 401 (-3.4A)
None
 0.63A 5zv2B-5eykA:
18.8		 5zv2B-5eykA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 903
VAL A 911
ALA A 928
LYS A 930
GLU A 947
GLY A 984
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
None
5U3  A1200 (-3.2A)
 0.67A 5zv2B-5f1zA:
28.5		 5zv2B-5f1zA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 730
VAL A 738
ALA A 756
LYS A 758
GLU A 775
VAL A 804
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
PP1  A2012 (-3.5A)
PP1  A2012 (-4.5A)
 0.44A 5zv2B-5fm2A:
34.1		 5zv2B-5fm2A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 730
VAL A 738
ALA A 756
LYS A 758
VAL A 804
ALA A 807
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
PP1  A2012 (-4.5A)
PP1  A2012 ( 3.5A)
 0.56A 5zv2B-5fm2A:
34.1		 5zv2B-5fm2A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 730
VAL A 738
ALA A 756
VAL A 804
ALA A 807
GLY A 810
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.5A)
PP1  A2012 ( 3.5A)
PTR  A 809 (-2.4A)
 0.63A 5zv2B-5fm2A:
34.1		 5zv2B-5fm2A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 599
VAL A 607
ALA A 625
LYS A 627
GLU A 644
MET A 648
GLY A 680
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 ( 4.0A)
 0.59A 5zv2B-5grnA:
26.5		 5zv2B-5grnA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 PHE A 837
VAL A 607
ALA A 625
LYS A 627
GLU A 644
MET A 648
GLY A 680
 748  A1001 (-3.7A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 ( 4.0A)
 0.88A 5zv2B-5grnA:
26.5		 5zv2B-5grnA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0c XYLOSE ISOMERASE

(Thermoanaerobacterium
thermosulfurigenes) 		PF01261
(AP_endonuc_2) 		3 TYR A 261
LEU A 253
ASP A 243
 None
 0.88A 5zv2B-1a0cA:
undetectable		 5zv2B-1a0cA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgp ARISTOLOCHENE
SYNTHASE

(Penicillium
roqueforti) 		no annotation 3 TYR A 319
LEU A 232
ASP A 299
 None
 0.86A 5zv2B-1dgpA:
undetectable		 5zv2B-1dgpA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f1u HOMOPROTOCATECHUATE
2,3-DIOXYGENASE

(Arthrobacter
globiformis) 		PF00903
(Glyoxalase) 		3 TYR A  35
LEU A  28
ASP A  47
 None
 0.79A 5zv2B-1f1uA:
undetectable		 5zv2B-1f1uA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iko EPHRIN-B2

(Mus musculus) 		PF00812
(Ephrin) 		3 TYR P  76
LEU P 145
ASP P 149
 None
 0.86A 5zv2B-1ikoP:
undetectable		 5zv2B-1ikoP:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j08 GLUTAREDOXIN-LIKE
PROTEIN

(Pyrococcus
horikoshii) 		PF00085
(Thioredoxin)
PF13192
(Thioredoxin_3) 		3 TYR A 181
LEU A 139
ASP A 204
 None
 0.72A 5zv2B-1j08A:
undetectable		 5zv2B-1j08A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		3 TYR A 268
LEU A 321
ASP A 332
 None
 0.60A 5zv2B-1k9aA:
26.0		 5zv2B-1k9aA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qwr MANNOSE-6-PHOSPHATE
ISOMERASE

(Bacillus
subtilis) 		PF01238
(PMI_typeI) 		3 TYR A 247
LEU A 112
ASP A  78
 None
 0.89A 5zv2B-1qwrA:
undetectable		 5zv2B-1qwrA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		3 TYR A 107
LEU A 158
ASP A 169
 None
 0.83A 5zv2B-1u5qA:
23.9		 5zv2B-1u5qA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkn PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE

(Chlorobaculum
tepidum) 		PF04371
(PAD_porph) 		3 TYR A 301
LEU A 282
ASP A 278
 None
 0.85A 5zv2B-1xknA:
undetectable		 5zv2B-1xknA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yd9 CORE HISTONE
MACRO-H2A.1

(Rattus
norvegicus) 		PF01661
(Macro) 		3 TYR A 183
LEU A  21
ASP A 191
 None
 0.86A 5zv2B-1yd9A:
undetectable		 5zv2B-1yd9A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		3 TYR A  86
LEU A 137
ASP A 148
 HYM  A 400 (-4.7A)
HYM  A 400 (-4.5A)
HYM  A 400 (-3.9A)
 0.70A 5zv2B-1zltA:
15.3		 5zv2B-1zltA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ako GLUTAMATE 5-KINASE

(Campylobacter
jejuni) 		PF00696
(AA_kinase) 		3 TYR A 168
LEU A 226
ASP A 143
 None
None
ADP  A 852 ( 4.6A)
 0.61A 5zv2B-2akoA:
undetectable		 5zv2B-2akoA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 TYR X  84
LEU X 137
ASP X 148
 STU  X 902 (-4.6A)
STU  X 902 (-4.4A)
STU  X 902 (-3.6A)
 0.64A 5zv2B-2dq7X:
30.2		 5zv2B-2dq7X:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2erc RRNA METHYL
TRANSFERASE

(Bacillus
subtilis) 		PF00398
(RrnaAD) 		3 TYR A 129
LEU A 136
ASP A 151
 None
 0.71A 5zv2B-2ercA:
undetectable		 5zv2B-2ercA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		3 TYR A 107
LEU A 158
ASP A 169
 STU  A 400 (-4.5A)
STU  A 400 ( 4.6A)
STU  A 400 (-3.6A)
 0.79A 5zv2B-2gcdA:
24.5		 5zv2B-2gcdA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwn DIHYDROOROTASE

(Porphyromonas
gingivalis) 		PF01979
(Amidohydro_1) 		3 TYR A 199
LEU A 210
ASP A 273
 None
 0.71A 5zv2B-2gwnA:
undetectable		 5zv2B-2gwnA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		3 TYR A 340
LEU A 393
ASP A 404
 H8H  A 534 (-4.3A)
H8H  A 534 (-4.5A)
H8H  A 534 (-4.2A)
 0.62A 5zv2B-2h8hA:
29.4		 5zv2B-2h8hA:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iu3 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Gallus gallus) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		3 TYR A 152
LEU A  25
ASP A 166
 None
 0.83A 5zv2B-2iu3A:
undetectable		 5zv2B-2iu3A:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nun AVIRULENCE B PROTEIN

(Pseudomonas
savastanoi) 		PF05394
(AvrB_AvrC) 		3 TYR A 222
LEU A 168
ASP A 232
 None
 0.89A 5zv2B-2nunA:
undetectable		 5zv2B-2nunA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ose PROBABLE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Mimivirus) 		PF00160
(Pro_isomerase) 		3 TYR A 121
LEU A 128
ASP A 153
 None
 0.82A 5zv2B-2oseA:
undetectable		 5zv2B-2oseA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmo SER/THR PROTEIN
KINASE

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		3 TYR X 119
LEU X 179
ASP X 190
 HMD  X 400 (-4.5A)
HMD  X 400 (-4.7A)
HMD  X 400 (-3.7A)
 0.67A 5zv2B-2pmoX:
20.7		 5zv2B-2pmoX:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyw UNCHARACTERIZED
PROTEIN

(Arabidopsis
thaliana) 		PF01636
(APH) 		3 TYR A 158
LEU A 317
ASP A 145
 None
 0.72A 5zv2B-2pywA:
8.0		 5zv2B-2pywA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkw PROTEIN KINASE

(Solanum
pimpinellifolium) 		PF07714
(Pkinase_Tyr) 		3 TYR B 116
LEU B 171
ASP B 182
 None
 0.70A 5zv2B-2qkwB:
23.3		 5zv2B-2qkwB:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyk CYCLIC AMP-SPECIFIC
PHOSPHODIESTERASE
HSPDE4A10

(Homo sapiens) 		PF00233
(PDEase_I) 		3 TYR A 371
LEU A 375
ASP A 323
 NPV  A   3 (-4.4A)
None
None
 0.87A 5zv2B-2qykA:
undetectable		 5zv2B-2qykA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uzz N-METHYL-L-TRYPTOPHA
N OXIDASE

(Escherichia
coli) 		PF01266
(DAO) 		3 TYR A  54
LEU A  63
ASP A 362
 None
 0.78A 5zv2B-2uzzA:
undetectable		 5zv2B-2uzzA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd5 DMPK PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		3 TYR A 150
LEU A 202
ASP A 213
 BI8  A1417 (-4.8A)
BI8  A1417 (-4.8A)
BI8  A1417 (-3.8A)
 0.84A 5zv2B-2vd5A:
19.6		 5zv2B-2vd5A:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz9 FATTY ACID SYNTHASE

(Sus scrofa) 		PF00107
(ADH_zinc_N)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08242
(Methyltransf_12)
PF08659
(KR)
PF14765
(PS-DH)
PF16197
(KAsynt_C_assoc) 		3 TYR A 993
LEU A1011
ASP A1073
 None
 0.77A 5zv2B-2vz9A:
undetectable		 5zv2B-2vz9A:
2.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xik SERINE/THREONINE
PROTEIN KINASE 25

(Homo sapiens) 		PF00069
(Pkinase) 		3 TYR A  97
LEU A 147
ASP A 158
 J60  A1294 (-4.5A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.6A)
 0.70A 5zv2B-2xikA:
19.0		 5zv2B-2xikA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yij PHOSPHOLIPASE
A1-IIGAMMA

(Arabidopsis
thaliana) 		PF01764
(Lipase_3) 		3 TYR A  95
LEU A  86
ASP A  59
 None
 0.89A 5zv2B-2yijA:
undetectable		 5zv2B-2yijA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahy BETA-GLUCOSIDASE

(Trichoderma
reesei) 		PF00232
(Glyco_hydro_1) 		3 TYR A 263
LEU A 271
ASP A 314
 None
 0.83A 5zv2B-3ahyA:
undetectable		 5zv2B-3ahyA:
9.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 TYR A 563
LEU A 630
ASP A 641
 None
C4F  A   1 (-4.6A)
C4F  A   1 (-4.5A)
 0.31A 5zv2B-3c4fA:
18.1		 5zv2B-3c4fA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 TYR A 268
LEU A 321
ASP A 332
 None
 0.59A 5zv2B-3d7uA:
31.0		 5zv2B-3d7uA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dev SH1221

(Staphylococcus
haemolyticus) 		PF01368
(DHH)
PF02272
(DHHA1) 		3 TYR A  40
LEU A 151
ASP A  29
 None
None
MG  A 323 (-3.5A)
 0.86A 5zv2B-3devA:
undetectable		 5zv2B-3devA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2

(Homo sapiens) 		PF00069
(Pkinase) 		3 TYR A 281
LEU A 340
ASP A 351
 None
ADP  A 900 (-4.6A)
ADP  A 900 ( 2.7A)
 0.77A 5zv2B-3g2fA:
24.2		 5zv2B-3g2fA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbj KIF13B PROTEIN

(Homo sapiens) 		PF00225
(Kinesin) 		3 TYR A 182
LEU A 171
ASP A 163
 None
 0.75A 5zv2B-3gbjA:
undetectable		 5zv2B-3gbjA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
DNA-DIRECTED RNA
POLYMERASE, SUBUNIT
G (RPOG)

(Sulfolobus
solfataricus) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
PF16992
(RNA_pol_RpbG) 		3 TYR A 507
LEU G  23
ASP G  41
 None
 0.83A 5zv2B-3hkzA:
undetectable		 5zv2B-3hkzA:
6.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzh CHEMOTAXIS RESPONSE
REGULATOR (CHEY-3)

(Borreliella
burgdorferi) 		PF00072
(Response_reg) 		3 TYR A  66
LEU A  78
ASP A  86
 None
BFD  A  79 ( 3.7A)
None
 0.78A 5zv2B-3hzhA:
undetectable		 5zv2B-3hzhA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5g MYOSIN CATALYTIC
LIGHT CHAIN LC-1,
MANTLE MUSCLE

(Todarodes
pacificus) 		PF13405
(EF-hand_6) 		3 TYR C  72
LEU C  36
ASP C  19
 None
None
CA  C1001 (-4.5A)
 0.67A 5zv2B-3i5gC:
undetectable		 5zv2B-3i5gC:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jar MICROTUBULE-ASSOCIAT
ED PROTEIN RP/EB
FAMILY MEMBER 3

(Homo sapiens) 		no annotation 3 TYR N 124
LEU N  51
ASP N 116
 None
 0.85A 5zv2B-3jarN:
undetectable		 5zv2B-3jarN:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		3 TYR A 715
LEU A 767
ASP A 778
 GOL  A 403 (-4.1A)
None
None
 0.59A 5zv2B-3kulA:
28.3		 5zv2B-3kulA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lg5 EPI-ISOZIZAENE
SYNTHASE

(Streptomyces
coelicolor) 		no annotation 3 TYR A 172
LEU A 121
ASP A 136
 None
 0.85A 5zv2B-3lg5A:
undetectable		 5zv2B-3lg5A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		3 TYR A 112
LEU A 165
ASP A 179
 QUE  A   1 (-4.9A)
None
QUE  A   1 (-2.9A)
 0.71A 5zv2B-3lm5A:
23.8		 5zv2B-3lm5A:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		3 TYR A 281
LEU A 339
ASP A 350
 LDN  A   1 ( 4.8A)
LDN  A   1 (-4.5A)
LDN  A   1 (-3.9A)
 0.77A 5zv2B-3mdyA:
24.8		 5zv2B-3mdyA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mos TRANSKETOLASE

(Homo sapiens) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		3 TYR A  83
LEU A  73
ASP A 183
 None
EDO  A 627 (-4.4A)
TPP  A 700 ( 4.5A)
 0.84A 5zv2B-3mosA:
undetectable		 5zv2B-3mosA:
7.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ner CYTOCHROME B5 TYPE B

(Homo sapiens) 		PF00173
(Cyt-b5) 		3 TYR A   6
LEU A  84
ASP A  53
 None
 0.79A 5zv2B-3nerA:
undetectable		 5zv2B-3nerA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntc FAB HEAVY CHAIN
FAB LIGHT CHAIN

(Homo sapiens;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 TYR H 102
LEU L  46
ASP L  91
 None
None
EDO  H 220 ( 4.5A)
 0.61A 5zv2B-3ntcH:
undetectable		 5zv2B-3ntcH:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oiz ANTISIGMA-FACTOR
ANTAGONIST, STAS

(Rhodobacter
sphaeroides) 		PF01740
(STAS) 		3 TYR A 406
LEU A 397
ASP A 400
 None
 0.89A 5zv2B-3oizA:
undetectable		 5zv2B-3oizA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		3 TYR A  92
LEU A 141
ASP A 152
 None
 0.39A 5zv2B-3oz6A:
21.2		 5zv2B-3oz6A:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		3 TYR A 627
LEU A 683
ASP A 694
 STU  A   1 (-4.4A)
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
 0.49A 5zv2B-3ppzA:
27.9		 5zv2B-3ppzA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s95 LIM DOMAIN KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 TYR A 415
LEU A 467
ASP A 478
 STU  A   1 (-4.7A)
STU  A   1 (-4.6A)
STU  A   1 ( 4.2A)
 0.64A 5zv2B-3s95A:
25.1		 5zv2B-3s95A:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sun DNA POLYMERASE

(Escherichia
virus RB69) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		3 TYR A 349
LEU A  93
ASP A  87
 None
 0.69A 5zv2B-3sunA:
undetectable		 5zv2B-3sunA:
6.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 TYR A 563
LEU A 630
ASP A 641
 07J  A   1 (-4.7A)
07J  A   1 ( 4.4A)
07J  A   1 (-4.7A)
 0.52A 5zv2B-3tt0A:
40.0		 5zv2B-3tt0A:
59.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfp POLY A POLYMERASE

(Aquifex
aeolicus;
synthetic
construct) 		PF01743
(PolyA_pol)
PF01966
(HD)
PF12627
(PolyA_pol_RNAbd) 		3 TYR A 343
LEU A 378
ASP A 418
 None
 0.86A 5zv2B-3wfpA:
undetectable		 5zv2B-3wfpA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wj2 CARBOXYLESTERASE

(Ferroplasma
acidiphilum) 		PF07859
(Abhydrolase_3) 		3 TYR A 217
LEU A 117
ASP A  37
 None
 0.88A 5zv2B-3wj2A:
undetectable		 5zv2B-3wj2A:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4z ANTIVIRAL HELICASE
SKI2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		3 TYR A1286
LEU A 384
ASP A 444
 None
 0.62A 5zv2B-4a4zA:
undetectable		 5zv2B-4a4zA:
6.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b96 CELLULOSE BINDING
DOMAIN-CONTAINING
PROTEIN

([Clostridium]
clariflavum) 		PF00942
(CBM_3) 		3 TYR A  10
LEU A 124
ASP A 134
 None
 0.81A 5zv2B-4b96A:
undetectable		 5zv2B-4b96A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5

(Homo sapiens) 		PF00069
(Pkinase) 		3 TYR A  91
LEU A 142
ASP A 153
 38R  A1000 (-4.8A)
38R  A1000 ( 4.5A)
38R  A1000 ( 4.2A)
 0.80A 5zv2B-4bgqA:
17.6		 5zv2B-4bgqA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4by4 FI18190P1

(Drosophila
melanogaster) 		PF00036
(EF-hand_1)
PF13499
(EF-hand_7) 		3 TYR A 108
LEU A 163
ASP A 161
 None
 0.69A 5zv2B-4by4A:
undetectable		 5zv2B-4by4A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		3 TYR A 320
LEU A 371
ASP A 382
 None
 0.45A 5zv2B-4c0tA:
22.7		 5zv2B-4c0tA:
5.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		3 TYR A  95
LEU A 146
ASP A 157
 STU  A1550 (-4.5A)
STU  A1550 (-4.3A)
STU  A1550 (-3.6A)
 0.83A 5zv2B-4cfhA:
23.1		 5zv2B-4cfhA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		3 TYR A 739
LEU A 789
ASP A 800
 None
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
 0.78A 5zv2B-4crsA:
16.1		 5zv2B-4crsA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 TYR A 904
LEU A 956
ASP A 967
 19S  A1201 (-4.7A)
19S  A1201 (-4.5A)
19S  A1201 ( 4.1A)
 0.86A 5zv2B-4hviA:
24.1		 5zv2B-4hviA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		3 TYR A 340
LEU A 393
ASP A 404
 0J9  A 601 ( 4.7A)
0J9  A 601 (-4.5A)
0J9  A 601 (-3.1A)
 0.69A 5zv2B-4k11A:
29.3		 5zv2B-4k11A:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l68 LEUCINE-RICH REPEAT
PROTEIN KINASE-LIKE
PROTEIN

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		3 TYR A 381
LEU A 436
ASP A 447
 None
 0.66A 5zv2B-4l68A:
15.8		 5zv2B-4l68A:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mdp BETA-GLUCOSIDASE

(Humicola grisea) 		PF00232
(Glyco_hydro_1) 		3 TYR A 273
LEU A 281
ASP A 324
 PO4  A 505 ( 4.9A)
None
None
 0.86A 5zv2B-4mdpA:
undetectable		 5zv2B-4mdpA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ml1 DSBP

(Klebsiella
pneumoniae) 		PF10411
(DsbC_N)
PF13098
(Thioredoxin_2) 		3 TYR A 173
LEU A 177
ASP A 100
 None
 0.87A 5zv2B-4ml1A:
undetectable		 5zv2B-4ml1A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mt0 MTRE PROTEIN

(Neisseria
gonorrhoeae) 		PF02321
(OEP) 		3 TYR A 452
LEU A 163
ASP A 283
 None
 0.87A 5zv2B-4mt0A:
undetectable		 5zv2B-4mt0A:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p2k EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		3 TYR A 694
LEU A 746
ASP A 757
 None
 0.58A 5zv2B-4p2kA:
31.5		 5zv2B-4p2kA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9z HUMAN PROTEIN KINASE
C THETA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		3 TYR A 460
LEU A 511
ASP A 522
 None
PZW  A 801 (-4.8A)
PZW  A 801 (-3.2A)
 0.60A 5zv2B-4q9zA:
17.6		 5zv2B-4q9zA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qpy COMPLEMENT C1Q-LIKE
PROTEIN 2

(Mus musculus) 		PF00386
(C1q) 		3 TYR A  22
LEU A  25
ASP A  28
 None
 0.80A 5zv2B-4qpyA:
undetectable		 5zv2B-4qpyA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qsl PYRUVATE CARBOXYLASE

(Listeria
monocytogenes) 		no annotation 3 TYR H 783
LEU H 794
ASP H 536
 None
 0.49A 5zv2B-4qslH:
undetectable		 5zv2B-4qslH:
5.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3m 2-DEHYDROPANTOATE
2-REDUCTASE

(Staphylococcus
aureus) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		3 TYR A 272
LEU A 204
ASP A 223
 None
 0.79A 5zv2B-4s3mA:
undetectable		 5zv2B-4s3mA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE

(Methylovorus
sp. MP688) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		3 TYR A   8
LEU A  20
ASP A 500
 None
None
FAD  A 700 (-4.3A)
 0.76A 5zv2B-4udrA:
undetectable		 5zv2B-4udrA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4um8 INTEGRIN BETA-6

(Homo sapiens) 		PF00362
(Integrin_beta)
PF17205
(PSI_integrin) 		3 TYR B 120
LEU B 155
ASP B 202
 None
 0.79A 5zv2B-4um8B:
undetectable		 5zv2B-4um8B:
7.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upi SULFATASE FAMILY
PROTEIN

(Ruegeria
pomeroyi) 		PF00884
(Sulfatase) 		3 TYR A 509
LEU A 516
ASP A 520
 None
 0.87A 5zv2B-4upiA:
undetectable		 5zv2B-4upiA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wfs TRNA-DIHYDROURIDINE(
20) SYNTHASE
[NAD(P)+]-LIKE

(Homo sapiens) 		PF01207
(Dus) 		3 TYR A 270
LEU A  25
ASP A  64
 None
 0.81A 5zv2B-4wfsA:
undetectable		 5zv2B-4wfsA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjl INACTIVE DIPEPTIDYL
PEPTIDASE 10

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		3 TYR A 767
LEU A 774
ASP A 585
 None
 0.82A 5zv2B-4wjlA:
undetectable		 5zv2B-4wjlA:
8.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x81 MYCINAMICIN III
3''-O-METHYLTRANSFER
ASE

(Micromonospora
griseorubida) 		PF05711
(TylF) 		3 TYR A  49
LEU A 143
ASP A 113
 MVI  A 305 ( 4.3A)
SAH  A 301 (-4.4A)
SAH  A 301 (-2.7A)
 0.88A 5zv2B-4x81A:
undetectable		 5zv2B-4x81A:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgm MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 3

(Homo sapiens) 		PF16953
(PRORP) 		3 TYR A 307
LEU A 279
ASP A 561
 None
 0.61A 5zv2B-4xgmA:
undetectable		 5zv2B-4xgmA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		3 TYR A 476
LEU A 528
ASP A 539
 None
 0.60A 5zv2B-4xi2A:
30.0		 5zv2B-4xi2A:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z5p CYTOCHROME P450
HYDROXYLASE

(Streptomyces
atroolivaceus) 		PF00067
(p450) 		3 TYR A 347
LEU A 339
ASP A  52
 None
 0.76A 5zv2B-4z5pA:
undetectable		 5zv2B-4z5pA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a21 PORTAL PROTEIN

(Bacillus phage
SPP1) 		PF05133
(Phage_prot_Gp6) 		3 TYR A 208
LEU A 181
ASP A  39
 None
 0.79A 5zv2B-5a21A:
undetectable		 5zv2B-5a21A:
12.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 TYR A 563
LEU A 630
ASP A 641
 38O  A1769 (-4.2A)
38O  A1769 (-4.6A)
38O  A1769 (-4.0A)
 0.46A 5zv2B-5a46A:
16.3		 5zv2B-5a46A:
78.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aff RIBOSOMAL PROTEIN
L11
SYMPORTIN 1

(Chaetomium
thermophilum) 		PF00281
(Ribosomal_L5)
PF00673
(Ribosomal_L5_C)
no annotation 		3 TYR C 117
LEU A 431
ASP A 434
 None
 0.72A 5zv2B-5affC:
undetectable		 5zv2B-5affC:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		3 TYR A 134
LEU A 185
ASP A 196
 5RC  A4000 (-4.5A)
None
5RC  A4000 (-3.6A)
 0.89A 5zv2B-5es1A:
22.8		 5zv2B-5es1A:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gza PROTEIN O-MANNOSE
KINASE

(Danio rerio) 		PF07714
(Pkinase_Tyr) 		3 TYR A 183
LEU A 210
ASP A 159
 None
 0.75A 5zv2B-5gzaA:
18.6		 5zv2B-5gzaA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idn CYCLIN-DEPENDENT
KINASE 8

(Homo sapiens) 		PF00069
(Pkinase) 		3 TYR A  99
LEU A 158
ASP A 173
 6A7  A 401 (-4.9A)
6A7  A 401 (-4.8A)
FMT  A 403 ( 3.3A)
 0.80A 5zv2B-5idnA:
21.5		 5zv2B-5idnA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbk BETA-GLUCOSIDASE

(Trichoderma
harzianum) 		PF00232
(Glyco_hydro_1) 		3 TYR A 263
LEU A 271
ASP A 314
 None
 0.83A 5zv2B-5jbkA:
undetectable		 5zv2B-5jbkA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbo BETA-GLUCOSIDASE

(Trichoderma
harzianum) 		PF00232
(Glyco_hydro_1) 		3 TYR A 280
LEU A 288
ASP A 332
 None
 0.87A 5zv2B-5jboA:
undetectable		 5zv2B-5jboA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jd4 LAE6

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		3 TYR A 222
LEU A 121
ASP A  37
 None
 0.85A 5zv2B-5jd4A:
undetectable		 5zv2B-5jd4A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jpn COMPLEMENT C4-A

(Homo sapiens) 		PF00207
(A2M)
PF01821
(ANATO)
PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl) 		3 TYR B 977
LEU B1362
ASP B 965
 PBM  B1515 ( 4.9A)
None
None
 0.85A 5zv2B-5jpnB:
undetectable		 5zv2B-5jpnB:
7.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkk MULTIDRUG RESISTANCE
ABC TRANSPORTER
ATP-BINDING AND
PERMEASE PROTEIN

(Thermus
thermophilus) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		3 TYR B 231
LEU B 238
ASP B 184
 None
 0.86A 5zv2B-5mkkB:
undetectable		 5zv2B-5mkkB:
9.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ofn DNA PRIMASE SMALL
SUBUNIT PRIS

(Sulfolobus
solfataricus) 		no annotation 3 TYR A 138
LEU A 110
ASP A 105
 None
 0.88A 5zv2B-5ofnA:
undetectable		 5zv2B-5ofnA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tla UBIQUITIN-LIKE
PROTEIN ISG15

(Mus musculus) 		PF00240
(ubiquitin) 		3 TYR A  94
LEU A 122
ASP A 131
 None
 0.79A 5zv2B-5tlaA:
undetectable		 5zv2B-5tlaA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		3 TYR A 171
LEU A 221
ASP A 232
 None
 0.67A 5zv2B-5u7qA:
18.9		 5zv2B-5u7qA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ub6 PHOSPHATE-BINDING
PROTEIN

(Xanthomonas
citri) 		no annotation 3 TYR A  47
LEU A  54
ASP A  90
 None
 0.89A 5zv2B-5ub6A:
undetectable		 5zv2B-5ub6A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vi6 HISTONE DEACETYLASE
8

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		3 TYR A 306
LEU A 179
ASP A 233
 EDO  A 407 ( 3.3A)
None
None
 0.71A 5zv2B-5vi6A:
undetectable		 5zv2B-5vi6A:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdh KINESIN-LIKE PROTEIN
KIFC1

(Homo sapiens) 		PF00225
(Kinesin) 		3 TYR A 402
LEU A 394
ASP A 375
 None
 0.82A 5zv2B-5wdhA:
undetectable		 5zv2B-5wdhA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bu3 BETA-LACTAMASE

(Escherichia
coli) 		no annotation 3 TYR A  60
LEU A  36
ASP A 277
 None
None
SO4  A 303 (-4.2A)
 0.88A 5zv2B-6bu3A:
undetectable		 5zv2B-6bu3A:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fd7 -

(-) 		no annotation 3 TYR A 143
LEU A 136
ASP A 161
 None
 0.87A 5zv2B-6fd7A:
undetectable		 5zv2B-6fd7A:
undetectable