SIMILAR PATTERNS OF AMINO ACIDS FOR 5ZV2_A_LEVA801_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ak6 DESTRIN

(Homo sapiens;
Sus scrofa) 		PF00241
(Cofilin_ADF) 		3 LYS A 112
LEU A 108
ASP A  79
 None
 0.87A 5zv2A-1ak6A:
undetectable		 5zv2A-1ak6A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c0a ASPARTYL TRNA
SYNTHETASE

(Escherichia
coli) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		3 LYS A 283
LEU A 541
ASP A 224
 None
 0.81A 5zv2A-1c0aA:
undetectable		 5zv2A-1c0aA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT

(Escherichia
coli) 		PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		3 LYS A  76
LEU A 933
ASP A1057
 None
 0.53A 5zv2A-1c30A:
undetectable		 5zv2A-1c30A:
5.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzv GLUCOSE-6-PHOSPHATE
ISOMERASE

(Sus scrofa) 		PF00342
(PGI) 		3 LYS A 496
LEU A  52
ASP A 404
 None
 0.84A 5zv2A-1gzvA:
undetectable		 5zv2A-1gzvA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hjv CHITINASE-3 LIKE
PROTEIN 1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		3 LYS A 377
LEU A 354
ASP A  47
 None
 0.82A 5zv2A-1hjvA:
undetectable		 5zv2A-1hjvA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ihc GEPHYRIN

(Rattus
norvegicus) 		PF00994
(MoCF_biosynth) 		3 LYS A  57
LEU A  79
ASP A  72
 None
 0.94A 5zv2A-1ihcA:
undetectable		 5zv2A-1ihcA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jpu GLYCEROL
DEHYDROGENASE

(Geobacillus
stearothermophilus) 		PF00465
(Fe-ADH) 		3 LYS A 365
LEU A 283
ASP A 314
 None
 0.87A 5zv2A-1jpuA:
undetectable		 5zv2A-1jpuA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ktc ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Gallus gallus) 		PF16499
(Melibiase_2)
PF17450
(Melibiase_2_C) 		3 LYS A 303
LEU A 256
ASP A 214
 None
 0.68A 5zv2A-1ktcA:
undetectable		 5zv2A-1ktcA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ljy MGP-40

(Capra hircus) 		PF00704
(Glyco_hydro_18) 		3 LYS A 356
LEU A 333
ASP A  26
 None
 0.84A 5zv2A-1ljyA:
undetectable		 5zv2A-1ljyA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ltz PHENYLALANINE-4-HYDR
OXYLASE

(Chromobacterium
violaceum) 		PF00351
(Biopterin_H) 		3 LYS A  86
LEU A 140
ASP A  73
 None
 0.62A 5zv2A-1ltzA:
undetectable		 5zv2A-1ltzA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		3 LYS A 608
LEU A 731
ASP A 742
 None
 0.91A 5zv2A-1lufA:
33.0		 5zv2A-1lufA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ub0 PHOSPHOMETHYLPYRIMID
INE KINASE

(Thermus
thermophilus) 		PF08543
(Phos_pyr_kin) 		3 LYS A 173
LEU A 133
ASP A 103
 None
 0.95A 5zv2A-1ub0A:
undetectable		 5zv2A-1ub0A:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4u HEMOGLOBIN ALPHA
CHAIN

(Thunnus thynnus) 		PF00042
(Globin) 		3 LYS A  12
LEU A  78
ASP A  76
 None
 0.84A 5zv2A-1v4uA:
undetectable		 5zv2A-1v4uA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zrz PROTEIN KINASE C,
IOTA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		3 LYS A 274
LEU A 376
ASP A 387
 BI1  A1000 (-3.5A)
BI1  A1000 (-4.8A)
BI1  A1000 (-4.5A)
 0.93A 5zv2A-1zrzA:
12.1		 5zv2A-1zrzA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buj SERINE/THREONINE-PRO
TEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		3 LYS A  49
LEU A 155
ASP A 166
 STU  A1301 ( 4.0A)
STU  A1301 ( 4.8A)
None
 0.90A 5zv2A-2bujA:
22.7		 5zv2A-2bujA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1q LUCIFERIN
4-MONOOXYGENASE

(Luciola
cruciata) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 LYS A 374
LEU A 399
ASP A 415
 None
 0.90A 5zv2A-2d1qA:
undetectable		 5zv2A-2d1qA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dh3 4F2 CELL-SURFACE
ANTIGEN HEAVY CHAIN

(Homo sapiens) 		PF00128
(Alpha-amylase) 		3 LYS A 116
LEU A 298
ASP A 296
 None
 0.76A 5zv2A-2dh3A:
undetectable		 5zv2A-2dh3A:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e6m WERNER SYNDROME
ATP-DEPENDENT
HELICASE HOMOLOG

(Mus musculus) 		PF01612
(DNA_pol_A_exo1) 		3 LYS A 102
LEU A  67
ASP A  62
 None
 0.87A 5zv2A-2e6mA:
undetectable		 5zv2A-2e6mA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7y TRNASE Z

(Thermotoga
maritima) 		PF12706
(Lactamase_B_2) 		3 LYS A 259
LEU A 212
ASP A 226
 None
 0.92A 5zv2A-2e7yA:
undetectable		 5zv2A-2e7yA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2glf PROBABLE M18-FAMILY
AMINOPEPTIDASE 1

(Thermotoga
maritima) 		PF02127
(Peptidase_M18) 		3 LYS A 180
LEU A 186
ASP A 165
 None
 0.94A 5zv2A-2glfA:
undetectable		 5zv2A-2glfA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		3 LYS A 454
LEU A 553
ASP A 564
 4ST  A1687 (-3.4A)
4ST  A1687 (-4.4A)
4ST  A1687 (-4.7A)
 0.85A 5zv2A-2j0jA:
32.7		 5zv2A-2j0jA:
7.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6i HD DOMAIN PROTEIN

(Enterococcus
faecalis) 		PF01966
(HD) 		3 LYS A 327
LEU A 258
ASP A 318
 None
 0.95A 5zv2A-2o6iA:
undetectable		 5zv2A-2o6iA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oaj PROTEIN SNI1

(Saccharomyces
cerevisiae) 		PF08596
(Lgl_C) 		3 LYS A 754
LEU A 787
ASP A 843
 None
 0.76A 5zv2A-2oajA:
undetectable		 5zv2A-2oajA:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ptz ENOLASE

(Trypanosoma
brucei) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		3 LYS A 118
LEU A 110
ASP A 378
 None
 0.84A 5zv2A-2ptzA:
undetectable		 5zv2A-2ptzA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd5 DMPK PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		3 LYS A 100
LEU A 202
ASP A 213
 BI8  A1417 (-4.2A)
BI8  A1417 (-4.8A)
BI8  A1417 (-3.8A)
 0.94A 5zv2A-2vd5A:
19.6		 5zv2A-2vd5A:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnp FICOLIN-1

(Homo sapiens) 		PF00147
(Fibrinogen_C) 		3 LYS F 230
LEU F 262
ASP F 138
 None
 0.71A 5zv2A-2wnpF:
undetectable		 5zv2A-2wnpF:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xik SERINE/THREONINE
PROTEIN KINASE 25

(Homo sapiens) 		PF00069
(Pkinase) 		3 LYS A  49
LEU A 147
ASP A 158
 None
J60  A1294 (-4.8A)
J60  A1294 ( 4.6A)
 0.69A 5zv2A-2xikA:
18.8		 5zv2A-2xikA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsb HYALURONOGLUCOSAMINI
DASE

(Oceanicola
granulosus) 		PF07555
(NAGidase) 		3 LYS A  39
LEU A  82
ASP A 115
 GDL  A1436 ( 3.8A)
None
None
 0.83A 5zv2A-2xsbA:
undetectable		 5zv2A-2xsbA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsx BETA-ENOLASE

(Homo sapiens) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		3 LYS A 120
LEU A 112
ASP A 378
 None
None
EDO  A 511 (-4.3A)
 0.86A 5zv2A-2xsxA:
undetectable		 5zv2A-2xsxA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xt6 2-OXOGLUTARATE
DECARBOXYLASE

(Mycolicibacterium
smegmatis) 		PF00198
(2-oxoacid_dh)
PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		3 LYS A 894
LEU A 972
ASP A1004
 None
None
CA  A2003 (-2.5A)
 0.87A 5zv2A-2xt6A:
undetectable		 5zv2A-2xt6A:
5.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3a PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT BETA ISOFORM

(Mus musculus) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B) 		3 LYS A 776
LEU A 804
ASP A 931
 None
None
GD9  A2058 (-3.2A)
 0.89A 5zv2A-2y3aA:
2.4		 5zv2A-2y3aA:
5.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM

(Homo sapiens) 		PF00069
(Pkinase) 		3 LYS A  53
LEU A 160
ASP A 171
 None
B49  A1294 (-4.4A)
B49  A1294 (-4.2A)
 0.67A 5zv2A-2y7jA:
23.1		 5zv2A-2y7jA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z3b ATP-DEPENDENT
PROTEASE HSLV

(Bacillus
subtilis) 		PF00227
(Proteasome) 		3 LYS A  65
LEU A  97
ASP A  91
 None
 0.90A 5zv2A-2z3bA:
undetectable		 5zv2A-2z3bA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bj1 HEMOGLOBIN ALPHA

(Perca
flavescens) 		PF00042
(Globin) 		3 LYS A  11
LEU A  77
ASP A  75
 None
 0.91A 5zv2A-3bj1A:
undetectable		 5zv2A-3bj1A:
22.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 LYS A 514
LEU A 630
ASP A 641
 None
C4F  A   1 (-4.6A)
C4F  A   1 (-4.5A)
 0.72A 5zv2A-3c4fA:
43.9		 5zv2A-3c4fA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		3 LYS A1250
LEU A  77
ASP A 144
 ALF  A 501 ( 3.0A)
None
MG  A 500 (-2.9A)
 0.89A 5zv2A-3cmtA:
undetectable		 5zv2A-3cmtA:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		3 LYS A2250
LEU A1077
ASP A1144
 ALF  A1501 ( 2.7A)
None
MG  A1500 (-3.2A)
 0.88A 5zv2A-3cmtA:
undetectable		 5zv2A-3cmtA:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		3 LYS A3250
LEU A2077
ASP A2144
 ALF  A2501 ( 2.9A)
None
MG  A2500 (-3.2A)
 0.89A 5zv2A-3cmtA:
undetectable		 5zv2A-3cmtA:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		3 LYS A4250
LEU A3077
ASP A3144
 ALF  A3501 ( 2.8A)
None
MG  A3500 (-3.3A)
 0.88A 5zv2A-3cmtA:
undetectable		 5zv2A-3cmtA:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3du4 ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(Bacillus
subtilis) 		PF00202
(Aminotran_3) 		3 LYS A 133
LEU A 247
ASP A 245
 None
 0.85A 5zv2A-3du4A:
undetectable		 5zv2A-3du4A:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ge2 LIPOPROTEIN,
PUTATIVE

(Streptococcus
pneumoniae) 		PF12182
(DUF3642) 		3 LYS A 127
LEU A 151
ASP A  81
 GOL  A 203 ( 3.0A)
None
GOL  A 204 ( 4.2A)
 0.95A 5zv2A-3ge2A:
undetectable		 5zv2A-3ge2A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hko CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 2
CALMODULIN-LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		3 LYS A  39
LEU A 182
ASP A 195
 ANP  A 329 (-2.7A)
ANP  A 329 (-4.4A)
MG  A 330 ( 2.9A)
 0.62A 5zv2A-3hkoA:
20.8		 5zv2A-3hkoA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		3 LYS A  82
LEU A 182
ASP A 193
 None
 0.84A 5zv2A-3iecA:
22.3		 5zv2A-3iecA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3im9 MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Staphylococcus
aureus) 		PF00698
(Acyl_transf_1) 		3 LYS A  15
LEU A  33
ASP A  21
 None
 0.92A 5zv2A-3im9A:
undetectable		 5zv2A-3im9A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k8k ALPHA-AMYLASE, SUSG

(Bacteroides
thetaiotaomicron) 		PF00128
(Alpha-amylase) 		3 LYS A 659
LEU A 597
ASP A  52
 None
PEG  A 951 ( 4.0A)
None
 0.93A 5zv2A-3k8kA:
undetectable		 5zv2A-3k8kA:
7.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kcn ADENYLATE CYCLASE
HOMOLOG

(Rhodopirellula
baltica) 		PF00072
(Response_reg) 		3 LYS A 108
LEU A  22
ASP A  13
 None
 0.91A 5zv2A-3kcnA:
undetectable		 5zv2A-3kcnA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l8k DIHYDROLIPOYL
DEHYDROGENASE

(Sulfolobus
solfataricus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 LYS A 394
LEU A 209
ASP A 213
 None
 0.93A 5zv2A-3l8kA:
undetectable		 5zv2A-3l8kA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llt SERINE/THREONINE
KINASE-1, PFLAMMER

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		3 LYS A 581
LEU A 684
ASP A 720
 ANP  A 877 (-2.7A)
None
ANP  A 877 (-2.9A)
 0.95A 5zv2A-3lltA:
21.1		 5zv2A-3lltA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		3 LYS A  62
LEU A 165
ASP A 179
 QUE  A   1 (-4.1A)
None
QUE  A   1 (-2.9A)
 0.82A 5zv2A-3lm5A:
23.5		 5zv2A-3lm5A:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n9x PHOSPHOTRANSFERASE

(Plasmodium
berghei) 		PF00069
(Pkinase) 		3 LYS A  57
LEU A 161
ASP A 172
 GOL  A 433 (-3.2A)
GOL  A 434 (-4.2A)
GOL  A 433 (-2.7A)
 0.83A 5zv2A-3n9xA:
20.2		 5zv2A-3n9xA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n9x PHOSPHOTRANSFERASE

(Plasmodium
berghei) 		PF00069
(Pkinase) 		3 LYS A 211
LEU A 175
ASP A  68
 None
 0.76A 5zv2A-3n9xA:
20.2		 5zv2A-3n9xA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nku DRRA

(Legionella
pneumophila) 		no annotation 3 LYS A  43
LEU A 136
ASP A  79
 None
 0.57A 5zv2A-3nkuA:
undetectable		 5zv2A-3nkuA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8o 6-PHOSPHOFRUCTOKINAS
E SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00365
(PFK) 		3 LYS A 792
LEU A 838
ASP A 802
 None
 0.94A 5zv2A-3o8oA:
undetectable		 5zv2A-3o8oA:
7.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3obk DELTA-AMINOLEVULINIC
ACID DEHYDRATASE

(Toxoplasma
gondii) 		PF00490
(ALAD) 		3 LYS A 213
LEU A 208
ASP A 134
 PBG  A 360 (-2.8A)
None
PBG  A 360 (-3.8A)
 0.92A 5zv2A-3obkA:
undetectable		 5zv2A-3obkA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		3 LYS A  40
LEU A 141
ASP A 152
 None
 0.71A 5zv2A-3oz6A:
21.6		 5zv2A-3oz6A:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q60 ROP5B

(Toxoplasma
gondii) 		PF14531
(Kinase-like) 		3 LYS A 263
LEU A 304
ASP A 407
 MLI  A 601 ( 2.8A)
ATP  A 600 ( 4.8A)
MG  A 602 ( 2.5A)
 0.84A 5zv2A-3q60A:
18.9		 5zv2A-3q60A:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rjy ENDOGLUCANASE
FNCEL5A

(Fervidobacterium
nodosum) 		PF00150
(Cellulase) 		3 LYS A 343
LEU A 313
ASP A  79
 None
 0.68A 5zv2A-3rjyA:
undetectable		 5zv2A-3rjyA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s95 LIM DOMAIN KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 LYS A 368
LEU A 467
ASP A 478
 STU  A   1 (-3.1A)
STU  A   1 (-4.6A)
STU  A   1 ( 4.2A)
 0.76A 5zv2A-3s95A:
25.0		 5zv2A-3s95A:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sag EXOSOME COMPONENT 10

(Homo sapiens) 		PF00570
(HRDC)
PF01612
(DNA_pol_A_exo1) 		3 LYS A 480
LEU A 216
ASP A 252
 LYS  A 480 ( 0.0A)
LEU  A 216 ( 0.6A)
ASP  A 252 ( 0.6A)
 0.84A 5zv2A-3sagA:
undetectable		 5zv2A-3sagA:
12.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 LYS A 514
LEU A 630
ASP A 641
 07J  A   1 (-4.5A)
07J  A   1 ( 4.4A)
07J  A   1 (-4.7A)
 0.58A 5zv2A-3tt0A:
41.6		 5zv2A-3tt0A:
59.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 LYS A 868
LEU A1035
ASP A1046
 None
LEV  A1201 (-4.8A)
GOL  A1210 ( 3.4A)
 0.42A 5zv2A-3wzdA:
30.1		 5zv2A-3wzdA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 LYS A1980
LEU A2086
ASP A2102
 VGH  A3000 ( 4.7A)
VGH  A3000 (-4.3A)
None
 0.89A 5zv2A-3zbfA:
31.7		 5zv2A-3zbfA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhr MULTIFUNCTIONAL
2-OXOGLUTARATE
METABOLISM ENZYME

(Mycolicibacterium
smegmatis) 		PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		3 LYS A 894
LEU A 972
ASP A1004
 None
None
CA  A2003 (-2.1A)
 0.92A 5zv2A-3zhrA:
undetectable		 5zv2A-3zhrA:
7.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amq L544

(Acanthamoeba
polyphaga
mimivirus) 		no annotation 3 LYS A 182
LEU A 273
ASP A 276
 None
 0.69A 5zv2A-4amqA:
2.6		 5zv2A-4amqA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 LYS A 588
LEU A 699
ASP A 710
 None
LTI  A1839 (-4.2A)
None
 0.85A 5zv2A-4at3A:
32.0		 5zv2A-4at3A:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 LYS A 123
LEU A 223
ASP A 234
 30K  A1365 (-3.8A)
30K  A1365 (-4.5A)
30K  A1365 (-3.3A)
 0.81A 5zv2A-4aw5A:
27.9		 5zv2A-4aw5A:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bev COPPER EFFLUX ATPASE

(Legionella
pneumophila) 		PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase) 		3 LYS A 135
LEU A 199
ASP A  80
 None
 0.62A 5zv2A-4bevA:
undetectable		 5zv2A-4bevA:
7.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5

(Homo sapiens) 		PF00069
(Pkinase) 		3 LYS A  42
LEU A 142
ASP A 153
 38R  A1000 (-3.4A)
38R  A1000 ( 4.5A)
38R  A1000 ( 4.2A)
 0.80A 5zv2A-4bgqA:
17.1		 5zv2A-4bgqA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		3 LYS A 269
LEU A 371
ASP A 382
 None
 0.64A 5zv2A-4c0tA:
22.8		 5zv2A-4c0tA:
5.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c5f MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE C

(Escherichia
coli) 		PF01464
(SLT)
PF11873
(DUF3393) 		3 LYS A 348
LEU A 185
ASP A  81
 None
 0.79A 5zv2A-4c5fA:
undetectable		 5zv2A-4c5fA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cr2 26S PROTEASE
REGULATORY SUBUNIT 4
HOMOLOG

(Saccharomyces
cerevisiae) 		PF00004
(AAA) 		3 LYS I 214
LEU I 202
ASP I 321
 None
 0.85A 5zv2A-4cr2I:
undetectable		 5zv2A-4cr2I:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4esa HEMOGLOBIN ALPHA
CHAIN

(Eleginops
maclovinus) 		PF00042
(Globin) 		3 LYS A  11
LEU A  77
ASP A  75
 None
 0.91A 5zv2A-4esaA:
undetectable		 5zv2A-4esaA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g7f ENOLASE

(Trypanosoma
cruzi) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		3 LYS A 118
LEU A 110
ASP A 378
 None
 0.84A 5zv2A-4g7fA:
undetectable		 5zv2A-4g7fA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gew 5'-TYROSYL-DNA
PHOSPHODIESTERASE

(Caenorhabditis
elegans) 		PF03372
(Exo_endo_phos)
PF14555
(UBA_4) 		3 LYS A 181
LEU A 190
ASP A 168
 None
 0.83A 5zv2A-4gewA:
undetectable		 5zv2A-4gewA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hfs UNCHARACTERIZED
PROTEIN YNCM

(Bacillus
subtilis) 		PF15493
(YrpD) 		3 LYS A 189
LEU A 193
ASP A 230
 None
SO4  A 301 ( 4.9A)
None
 0.73A 5zv2A-4hfsA:
undetectable		 5zv2A-4hfsA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3b M1 FAMILY
AMINOPEPTIDASE

(Plasmodium
falciparum) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		3 LYS A 981
LEU A 933
ASP A 947
 None
 0.81A 5zv2A-4j3bA:
undetectable		 5zv2A-4j3bA:
6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kr5 GLUTAMINE ABC
TRANSPORTER PERMEASE
AND SUBSTRATE
BINDING PROTEIN
PROTEIN

(Lactococcus
lactis) 		PF00497
(SBP_bac_3) 		3 LYS A 368
LEU A 406
ASP A 356
 None
 0.87A 5zv2A-4kr5A:
undetectable		 5zv2A-4kr5A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6

(Homo sapiens) 		PF00069
(Pkinase) 		3 LYS A 436
LEU A 533
ASP A 544
 None
B49  A 701 (-4.5A)
B49  A 701 (-4.6A)
 0.80A 5zv2A-4ks8A:
23.0		 5zv2A-4ks8A:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lry PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK

(Escherichia
coli) 		PF02733
(Dak1) 		3 LYS A 179
LEU A 342
ASP A 336
 None
 0.89A 5zv2A-4lryA:
undetectable		 5zv2A-4lryA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		3 LYS B  53
LEU B 151
ASP B 162
 ADP  B 500 (-3.1A)
ADP  B 500 (-4.7A)
ADP  B 500 ( 3.4A)
 0.94A 5zv2A-4o27B:
20.1		 5zv2A-4o27B:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		3 LYS A 216
LEU A 321
ASP A 332
 None
ANW  A 601 (-4.9A)
None
 0.89A 5zv2A-4wboA:
22.1		 5zv2A-4wboA:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wmj GLUCOSE-6-PHOSPHATE
ISOMERASE

(Colias
eurytheme) 		PF00342
(PGI) 		3 LYS A 500
LEU A  57
ASP A 408
 None
 0.75A 5zv2A-4wmjA:
undetectable		 5zv2A-4wmjA:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x2m MTR2

(Chaetomium
thermophilum) 		no annotation 3 LYS A  38
LEU A 174
ASP A 160
 None
 0.86A 5zv2A-4x2mA:
undetectable		 5zv2A-4x2mA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbr PROTEIN
FAM212A,SERINE/THREO
NINE-PROTEIN KINASE
PAK 4

(Homo sapiens) 		PF00069
(Pkinase)
PF15342
(FAM212) 		3 LYS A 350
LEU A 447
ASP A 458
 ATP  A 601 (-2.8A)
None
ATP  A 601 ( 2.5A)
 0.84A 5zv2A-4xbrA:
17.9		 5zv2A-4xbrA:
16.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 LYS A 503
LEU A 619
ASP A 630
 40M  A1002 (-4.0A)
40M  A1002 (-4.5A)
40M  A1002 (-4.5A)
 0.60A 5zv2A-4xcuA:
38.4		 5zv2A-4xcuA:
65.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey9 LONG-CHAIN-FATTY-ACI
D--AMP LIGASE FADD32

(Mycobacterium
marinum) 		PF00501
(AMP-binding) 		3 LYS A 600
LEU A 226
ASP A 231
 5SV  A 701 (-2.6A)
None
5SV  A 701 (-2.9A)
 0.88A 5zv2A-5ey9A:
undetectable		 5zv2A-5ey9A:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax) 		PF00027
(cNMP_binding)
PF00069
(Pkinase) 		3 LYS A 563
LEU A 664
ASP A 675
 4ZS  A 901 (-3.9A)
4ZS  A 901 (-3.6A)
None
 0.84A 5zv2A-5ezrA:
18.3		 5zv2A-5ezrA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gxd AMP-DEPENDENT
SYNTHETASE AND
LIGASE

(Dinoroseobacter
shibae) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		3 LYS A 341
LEU A 363
ASP A 369
 None
 0.67A 5zv2A-5gxdA:
undetectable		 5zv2A-5gxdA:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 LYS A 745
LEU A 844
ASP A 855
 6HJ  A1101 (-4.2A)
6HJ  A1101 ( 4.8A)
6HJ  A1101 (-4.3A)
 0.69A 5zv2A-5j9zA:
31.2		 5zv2A-5j9zA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mov CASEIN KINASE II
SUBUNIT ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		3 LYS A  77
LEU A  85
ASP A 175
 None
None
HC4  A 401 (-4.0A)
 0.89A 5zv2A-5movA:
20.1		 5zv2A-5movA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oat SERINE/THREONINE-PRO
TEIN KINASE PINK1,
MITOCHONDRIAL-LIKE
PROTEIN

(Tribolium
castaneum) 		no annotation 3 LYS A 196
LEU A 344
ASP A 359
 None
None
MG  A 601 (-3.1A)
 0.80A 5zv2A-5oatA:
18.6		 5zv2A-5oatA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5okt CASEIN KINASE I
ISOFORM DELTA

(Homo sapiens) 		no annotation 3 LYS C  38
LEU C 135
ASP C 149
 9XK  C 301 ( 4.6A)
9XK  C 301 (-4.6A)
None
 0.85A 5zv2A-5oktC:
19.9		 5zv2A-5oktC:
29.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo sapiens) 		no annotation 3 LYS A  40
LEU A 139
ASP A 150
 7LV  A 401 (-3.0A)
7LV  A 401 (-4.9A)
7LV  A 401 (-4.2A)
 0.86A 5zv2A-5tvtA:
22.3		 5zv2A-5tvtA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		3 LYS A 170
LEU A  34
ASP A 534
 None
 0.91A 5zv2A-5uuuA:
21.3		 5zv2A-5uuuA:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7i PALMITOYLTRANSFERASE
ZDHHC17

(Homo sapiens) 		PF12796
(Ank_2) 		3 LYS A 266
LEU A 229
ASP A 252
 None
 0.90A 5zv2A-5w7iA:
undetectable		 5zv2A-5w7iA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wro ENOLASE

(Drosophila
melanogaster) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		3 LYS A 187
LEU A 179
ASP A 446
 None
 0.87A 5zv2A-5wroA:
undetectable		 5zv2A-5wroA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53

(Saccharomyces
cerevisiae) 		no annotation 3 LYS A 227
LEU A 326
ASP A 339
 None
 0.91A 5zv2A-5xzwA:
18.4		 5zv2A-5xzwA:
12.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4

(Homo sapiens) 		no annotation 3 LYS A 213
LEU A 318
ASP A 329
 CJT  A 502 (-3.0A)
CJT  A 502 (-4.7A)
CJT  A 502 ( 4.0A)
 0.73A 5zv2A-6f3dA:
23.1		 5zv2A-6f3dA:
34.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f79 -

(-) 		no annotation 3 LYS A 302
LEU A  99
ASP A  93
 None
 0.75A 5zv2A-6f79A:
undetectable		 5zv2A-6f79A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdy -

(-) 		no annotation 3 LYS U  44
LEU U 144
ASP U 157
 DB8  U 301 ( 4.0A)
DB8  U 301 (-4.8A)
DB8  U 301 (-3.6A)
 0.89A 5zv2A-6fdyU:
21.5		 5zv2A-6fdyU:
undetectable