SIMILAR PATTERNS OF AMINO ACIDS FOR 5ZV2_A_LEVA801_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k9a | CARBOXYL-TERMINALSRC KINASE (Rattusnorvegicus) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 6 | VAL A 209ALA A 220GLU A 236MET A 240TYR A 268GLY A 272 | None | 0.62A | 5zv2A-1k9aA:30.7 | 5zv2A-1k9aA:11.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1opk | PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1 (Mus musculus) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 8 | LEU A 267GLY A 268VAL A 275ALA A 288GLU A 305MET A 309GLY A 340ALA A 399 | P16 A 2 ( 4.2A)P16 A 2 ( 4.3A)P16 A 2 (-4.5A)P16 A 2 (-3.4A)P16 A 2 (-4.2A)P16 A 2 (-3.3A)P16 A 2 (-3.4A)P16 A 2 (-3.5A) | 0.50A | 5zv2A-1opkA:31.5 | 5zv2A-1opkA:10.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pem | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 2ALPHA CHAIN (Salmonellaenterica) |
PF00317(Ribonuc_red_lgN)PF02867(Ribonuc_red_lgC)PF08343(RNR_N) | 7 | LEU A 286GLY A 255PHE A 209VAL A 257VAL A 234ALA A 241ALA A 193 | None | 1.47A | 5zv2A-1pemA:undetectable | 5zv2A-1pemA:8.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rjb | FL CYTOKINE RECEPTOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | LEU A 616GLY A 617VAL A 624ALA A 642GLU A 661TYR A 693GLY A 697 | None | 0.88A | 5zv2A-1rjbA:32.7 | 5zv2A-1rjbA:15.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A 595VAL A 603ALA A 621GLU A 640TYR A 672GLY A 676 | STI A 3 ( 3.8A)STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.6A)STI A 3 ( 4.0A)STI A 3 ( 3.8A) | 0.45A | 5zv2A-1t46A:28.7 | 5zv2A-1t46A:18.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u59 | TYROSINE-PROTEINKINASE ZAP-70 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | LEU A 344VAL A 352ALA A 367GLU A 386MET A 390ALA A 417GLY A 420 | STU A 100 (-3.8A)STU A 100 (-4.8A)STU A 100 (-3.2A)NoneNoneSTU A 100 (-3.7A)STU A 100 (-3.5A) | 0.47A | 5zv2A-1u59A:30.1 | 5zv2A-1u59A:15.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zlt | SERINE/THREONINE-PROTEIN KINASE CHK1 (Homo sapiens) |
PF00069(Pkinase) | 6 | LEU A 15VAL A 23ALA A 36GLU A 55TYR A 86GLY A 90 | HYM A 400 (-4.2A)HYM A 400 (-4.3A)HYM A 400 (-3.5A)NoneHYM A 400 (-4.7A)None | 0.44A | 5zv2A-1zltA:21.3 | 5zv2A-1zltA:22.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dq7 | PROTO-ONCOGENETYROSINE-PROTEINKINASE FYN (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | LEU X 17GLY X 18ALA X 37GLU X 54MET X 58TYR X 84ALA X 147 | STU X 902 (-3.8A)STU X 902 ( 3.7A)STU X 902 (-3.1A)STU X 902 ( 4.4A)NoneSTU X 902 (-4.6A)STU X 902 ( 4.1A) | 1.08A | 5zv2A-2dq7X:30.7 | 5zv2A-2dq7X:16.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dq7 | PROTO-ONCOGENETYROSINE-PROTEINKINASE FYN (Homo sapiens) |
PF07714(Pkinase_Tyr) | 8 | LEU X 17VAL X 25ALA X 37GLU X 54MET X 58TYR X 84GLY X 88ALA X 147 | STU X 902 (-3.8A)STU X 902 ( 4.8A)STU X 902 (-3.1A)STU X 902 ( 4.4A)NoneSTU X 902 (-4.6A)STU X 902 (-3.5A)STU X 902 ( 4.1A) | 0.62A | 5zv2A-2dq7X:30.7 | 5zv2A-2dq7X:16.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h8h | PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC (Homo sapiens) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 6 | LEU A 273VAL A 281ALA A 293TYR A 340GLY A 344ALA A 403 | H8H A 534 (-3.8A)H8H A 534 (-4.4A)H8H A 534 (-3.2A)H8H A 534 (-4.3A)H8H A 534 (-3.3A)H8H A 534 ( 4.0A) | 0.63A | 5zv2A-2h8hA:29.6 | 5zv2A-2h8hA:9.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hak | SERINE/THREONINE-PROTEIN KINASE MARK1 (Homo sapiens) |
PF00069(Pkinase)PF00627(UBA) | 7 | VAL A 67ALA A 80MET A 104TYR A 131ALA A 132GLY A 135ALA A 192 | None | 0.96A | 5zv2A-2hakA:20.5 | 5zv2A-2hakA:14.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hk5 | TYROSINE-PROTEINKINASE HCK (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | LEU A 251VAL A 259ALA A 271GLU A 288MET A 292GLY A 322ALA A 381 | 1BM A 499 ( 3.7A)1BM A 499 ( 4.8A)1BM A 499 (-3.6A)1BM A 499 (-3.2A)1BM A 499 ( 3.8A)1BM A 499 (-3.5A)1BM A 499 ( 3.7A) | 1.05A | 5zv2A-2hk5A:25.2 | 5zv2A-2hk5A:15.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hz0 | PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | LEU A 248VAL A 256ALA A 269GLU A 286MET A 290GLY A 321ALA A 380 | GIN A 600 ( 4.6A)GIN A 600 ( 4.7A)GIN A 600 (-3.1A)GIN A 600 (-3.6A)GIN A 600 (-3.2A)NoneGIN A 600 (-3.1A) | 0.67A | 5zv2A-2hz0A:30.0 | 5zv2A-2hz0A:16.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i0e | PROTEIN KINASEC-BETA II (Homo sapiens) |
PF00069(Pkinase)PF00433(Pkinase_C) | 6 | LEU A 348VAL A 356ALA A 369GLU A 390TYR A 422ALA A 483 | PDS A 901 (-3.9A)PDS A 901 (-4.2A)PDS A 901 (-3.3A)NonePDS A 901 (-4.7A)PDS A 901 (-3.4A) | 0.70A | 5zv2A-2i0eA:9.0 | 5zv2A-2i0eA:14.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2og8 | PROTO-ONCOGENETYROSINE-PROTEINKINASE LCK (Homo sapiens) |
PF07714(Pkinase_Tyr) | 8 | LEU A 251PHE A 383VAL A 259ALA A 271GLU A 288MET A 292GLY A 322ALA A 381 | None1N8 A 501 ( 4.3A)None1N8 A 501 ( 3.4A)1N8 A 501 ( 3.6A)1N8 A 501 ( 3.6A)1N8 A 501 ( 3.5A)1N8 A 501 ( 3.3A) | 0.88A | 5zv2A-2og8A:30.0 | 5zv2A-2og8A:20.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2og8 | PROTO-ONCOGENETYROSINE-PROTEINKINASE LCK (Homo sapiens) |
PF07714(Pkinase_Tyr) | 8 | LEU A 251VAL A 259ALA A 271GLU A 288MET A 292TYR A 318GLY A 322ALA A 381 | NoneNone1N8 A 501 ( 3.4A)1N8 A 501 ( 3.6A)1N8 A 501 ( 3.6A)1N8 A 501 ( 3.7A)1N8 A 501 ( 3.5A)1N8 A 501 ( 3.3A) | 0.73A | 5zv2A-2og8A:30.0 | 5zv2A-2og8A:20.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ogv | MACROPHAGECOLONY-STIMULATINGFACTOR 1 RECEPTORPRECURSOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | LEU A 588GLY A 589ALA A 614GLU A 633MET A 637TYR A 665GLY A 669 | None | 0.96A | 5zv2A-2ogvA:32.5 | 5zv2A-2ogvA:24.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ogv | MACROPHAGECOLONY-STIMULATINGFACTOR 1 RECEPTORPRECURSOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | LEU A 588VAL A 596ALA A 614GLU A 633MET A 637TYR A 665GLY A 669 | None | 0.58A | 5zv2A-2ogvA:32.5 | 5zv2A-2ogvA:24.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p4i | ANGIOPOIETIN-1RECEPTOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | VAL A 838ALA A 853TYR A 904ALA A 905GLY A 908ALA A 981 | MR9 A 301 (-4.6A)MR9 A 301 (-3.5A)MR9 A 301 (-3.8A)MR9 A 301 (-3.6A)MR9 A 301 ( 3.8A)MR9 A 301 (-3.2A) | 0.69A | 5zv2A-2p4iA:25.1 | 5zv2A-2p4iA:12.90 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2psq | FIBROBLAST GROWTHFACTOR RECEPTOR 2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 11 | LEU A 487GLY A 488VAL A 495ALA A 515GLU A 534MET A 538VAL A 564TYR A 566ALA A 567GLY A 570ALA A 643 | None | 0.53A | 5zv2A-2psqA:36.8 | 5zv2A-2psqA:45.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vd5 | DMPK PROTEIN (Homo sapiens) |
PF00069(Pkinase) | 6 | VAL A 85ALA A 98GLU A 119TYR A 150GLY A 154ALA A 212 | BI8 A1417 ( 4.7A)BI8 A1417 ( 3.8A)BI8 A1417 ( 4.9A)BI8 A1417 (-4.8A)NoneBI8 A1417 ( 4.1A) | 0.77A | 5zv2A-2vd5A:19.5 | 5zv2A-2vd5A:11.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x4f | MYOSIN LIGHT CHAINKINASE FAMILY MEMBER4 (Homo sapiens) |
PF00069(Pkinase) | 6 | LEU A 112VAL A 120ALA A 133MET A 155TYR A 182GLY A 186 | 16X A1374 (-4.1A)16X A1374 (-4.8A)16X A1374 ( 3.8A)None16X A1374 (-4.1A)16X A1374 (-4.0A) | 0.58A | 5zv2A-2x4fA:22.3 | 5zv2A-2x4fA:14.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xik | SERINE/THREONINEPROTEIN KINASE 25 (Homo sapiens) |
PF00069(Pkinase) | 6 | GLY A 27ALA A 47GLU A 66TYR A 97GLY A 101ALA A 157 | J60 A1294 ( 4.1A)J60 A1294 (-3.3A)NoneJ60 A1294 (-4.5A)J60 A1294 ( 3.8A)J60 A1294 ( 4.2A) | 0.77A | 5zv2A-2xikA:18.8 | 5zv2A-2xikA:14.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xik | SERINE/THREONINEPROTEIN KINASE 25 (Homo sapiens) |
PF00069(Pkinase) | 6 | VAL A 34ALA A 47GLU A 66TYR A 97GLY A 101ALA A 157 | J60 A1294 ( 4.9A)J60 A1294 (-3.3A)NoneJ60 A1294 (-4.5A)J60 A1294 ( 3.8A)J60 A1294 ( 4.2A) | 0.57A | 5zv2A-2xikA:18.8 | 5zv2A-2xikA:14.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z8c | INSULIN RECEPTOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A1002VAL A1010ALA A1028GLU A1047MET A1051GLY A1082 | S91 A 1 ( 4.1A)S91 A 1 ( 4.9A)S91 A 1 (-3.2A)NoneNoneS91 A 1 (-3.3A) | 0.69A | 5zv2A-2z8cA:22.6 | 5zv2A-2z8cA:13.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a62 | RIBOSOMAL PROTEIN S6KINASE BETA-1 (Homo sapiens) |
PF00069(Pkinase) | 6 | LEU A 97VAL A 105ALA A 121GLU A 143TYR A 174GLY A 178 | STU A 400 (-3.8A)STU A 400 (-4.9A)STU A 400 (-3.1A)STU A 400 ( 4.3A)STU A 400 (-4.7A)STU A 400 ( 4.4A) | 0.47A | 5zv2A-3a62A:18.3 | 5zv2A-3a62A:13.21 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3b2t | FIBROBLAST GROWTHFACTOR RECEPTOR 2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 9 | LEU A 487GLY A 488VAL A 495ALA A 515GLU A 534MET A 538VAL A 564TYR A 566ALA A 567 | M33 A1996 (-4.0A)M33 A1996 ( 3.8A)M33 A1996 ( 4.7A)M33 A1996 (-3.3A)NoneNoneNoneM33 A1996 ( 4.7A)M33 A1996 (-3.8A) | 1.02A | 5zv2A-3b2tA:28.6 | 5zv2A-3b2tA:75.29 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3b2t | FIBROBLAST GROWTHFACTOR RECEPTOR 2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 9 | LEU A 487GLY A 488VAL A 495ALA A 515MET A 538VAL A 564TYR A 566ALA A 567ALA A 643 | M33 A1996 (-4.0A)M33 A1996 ( 3.8A)M33 A1996 ( 4.7A)M33 A1996 (-3.3A)NoneNoneM33 A1996 ( 4.7A)M33 A1996 (-3.8A)None | 0.93A | 5zv2A-3b2tA:28.6 | 5zv2A-3b2tA:75.29 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3b2t | FIBROBLAST GROWTHFACTOR RECEPTOR 2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 9 | LEU A 487VAL A 495ALA A 515MET A 538VAL A 564TYR A 566ALA A 567GLY A 570ALA A 643 | M33 A1996 (-4.0A)M33 A1996 ( 4.7A)M33 A1996 (-3.3A)NoneNoneM33 A1996 ( 4.7A)M33 A1996 (-3.8A)M33 A1996 ( 4.8A)None | 0.46A | 5zv2A-3b2tA:28.6 | 5zv2A-3b2tA:75.29 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3c4f | BASIC FIBROBLASTGROWTH FACTORRECEPTOR 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | GLY A 487PHE A 489VAL A 492GLU A 531MET A 535VAL A 561ALA A 640 | NoneC4F A 1 (-3.7A)NoneNoneC4F A 1 ( 3.7A)C4F A 1 ( 4.8A)C4F A 1 (-3.6A) | 1.34A | 5zv2A-3c4fA:43.9 | 5zv2A-3c4fA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3c4f | BASIC FIBROBLASTGROWTH FACTORRECEPTOR 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 12 | LEU A 484GLY A 485PHE A 489VAL A 492ALA A 512GLU A 531MET A 535VAL A 561TYR A 563ALA A 564GLY A 567ALA A 640 | C4F A 1 ( 3.9A)C4F A 1 ( 4.5A)C4F A 1 (-3.7A)NoneC4F A 1 (-3.3A)NoneC4F A 1 ( 3.7A)C4F A 1 ( 4.8A)NoneC4F A 1 (-3.5A)NoneC4F A 1 (-3.6A) | 0.50A | 5zv2A-3c4fA:43.9 | 5zv2A-3c4fA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d7u | TYROSINE-PROTEINKINASE CSK (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | VAL A 209ALA A 220GLU A 236MET A 240TYR A 268GLY A 272 | None | 0.62A | 5zv2A-3d7uA:25.8 | 5zv2A-3d7uA:15.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eb0 | PUTATIVEUNCHARACTERIZEDPROTEIN (Cryptosporidiumparvum) |
PF00069(Pkinase) | 6 | LEU A 15VAL A 23ALA A 36GLU A 50MET A 54TYR A 119 | DRK A 384 (-3.8A)NoneDRK A 384 (-3.5A)NoneNoneDRK A 384 (-4.4A) | 0.55A | 5zv2A-3eb0A:20.5 | 5zv2A-3eb0A:12.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fe3 | MAP/MICROTUBULEAFFINITY-REGULATINGKINASE 3 (Homo sapiens) |
PF00069(Pkinase)PF00627(UBA) | 7 | VAL A 70ALA A 83MET A 107TYR A 134ALA A 135GLY A 138ALA A 195 | None | 0.83A | 5zv2A-3fe3A:19.0 | 5zv2A-3fe3A:11.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hng | VASCULAR ENDOTHELIALGROWTH FACTORRECEPTOR 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | LEU A 833VAL A 841ALA A 859GLU A 878VAL A 909TYR A 911GLY A 915 | 8ST A2001 ( 4.7A)8ST A2001 ( 4.6A)8ST A2001 ( 3.8A)8ST A2001 (-3.7A)8ST A2001 (-4.1A)8ST A2001 (-4.9A)None | 0.23A | 5zv2A-3hngA:33.7 | 5zv2A-3hngA:14.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iec | SERINE/THREONINE-PROTEIN KINASE MARK2 (Homo sapiens) |
PF00069(Pkinase)PF00627(UBA) | 7 | VAL A 67ALA A 80MET A 104TYR A 131ALA A 132GLY A 135ALA A 192 | None | 0.71A | 5zv2A-3iecA:22.3 | 5zv2A-3iecA:13.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lm5 | SERINE/THREONINE-PROTEIN KINASE 17B (Homo sapiens) |
PF00069(Pkinase) | 7 | LEU A 39VAL A 47ALA A 60GLU A 80TYR A 112ALA A 113GLY A 116 | QUE A 1 ( 3.8A)QUE A 1 ( 4.6A)QUE A 1 (-3.2A)QUE A 1 (-3.1A)QUE A 1 (-4.9A)QUE A 1 (-3.9A)None | 0.67A | 5zv2A-3lm5A:23.5 | 5zv2A-3lm5A:12.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mdy | BONE MORPHOGENETICPROTEIN RECEPTORTYPE-1B (Homo sapiens) |
PF07714(Pkinase_Tyr)PF08515(TGF_beta_GS) | 6 | VAL A 218ALA A 229GLU A 244TYR A 281GLY A 285ALA A 349 | LDN A 1 ( 4.8A)LDN A 1 (-3.6A)NoneLDN A 1 ( 4.8A)LDN A 1 (-3.3A)LDN A 1 ( 3.8A) | 0.77A | 5zv2A-3mdyA:25.1 | 5zv2A-3mdyA:12.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mvj | CAMP-DEPENDENTPROTEIN KINASECATALYTIC SUBUNITALPHA (Homo sapiens) |
PF00069(Pkinase) | 6 | LEU A 49VAL A 57ALA A 70GLU A 91TYR A 122GLY A 126 | XFE A 351 (-4.2A)XFE A 351 ( 4.5A)XFE A 351 (-3.2A)NoneNoneNone | 0.44A | 5zv2A-3mvjA:20.5 | 5zv2A-3mvjA:15.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nuu | PKB-LIKE (Homo sapiens) |
PF00069(Pkinase) | 8 | LEU A 88VAL A 96ALA A 109GLU A 130MET A 134TYR A 161ALA A 162GLY A 165 | JOZ A 361 (-4.1A)JOZ A 361 ( 4.7A)JOZ A 361 (-3.4A)SO4 A 5 (-3.1A)NoneNoneJOZ A 361 (-3.8A)None | 0.56A | 5zv2A-3nuuA:23.1 | 5zv2A-3nuuA:15.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qfv | CDC42BPB PROTEIN (Homo sapiens) |
PF00069(Pkinase) | 6 | VAL A 90ALA A 103GLU A 124TYR A 155GLY A 159ALA A 217 | NM7 A 416 (-3.7A)NM7 A 416 ( 3.7A)EDO A 417 (-4.0A)NM7 A 416 (-4.4A)NoneNM7 A 416 ( 4.5A) | 0.76A | 5zv2A-3qfvA:18.5 | 5zv2A-3qfvA:13.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s95 | LIM DOMAIN KINASE 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A 345GLU A 384MET A 388TYR A 415GLY A 419ALA A 477 | STU A 1 (-3.8A)STU A 1 (-3.7A)NoneSTU A 1 (-4.7A)STU A 1 (-3.6A)STU A 1 ( 4.1A) | 0.80A | 5zv2A-3s95A:25.0 | 5zv2A-3s95A:14.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sxs | CYTOPLASMICTYROSINE-PROTEINKINASE BMX (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A 423VAL A 431ALA A 443MET A 464TYR A 491GLY A 495 | PP2 A 1 (-4.1A)PP2 A 1 (-4.5A)PP2 A 1 (-3.2A)PP2 A 1 ( 4.3A)PP2 A 1 ( 4.9A)PP2 A 1 ( 4.2A) | 0.72A | 5zv2A-3sxsA:30.5 | 5zv2A-3sxsA:14.08 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3tt0 | BASIC FIBROBLASTGROWTH FACTORRECEPTOR 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 9 | LEU A 484GLY A 485ALA A 512GLU A 531MET A 535VAL A 561TYR A 563ALA A 564ALA A 640 | 07J A 1 ( 4.3A)07J A 1 ( 4.9A)07J A 1 (-3.5A)07J A 1 (-3.8A)07J A 1 (-3.8A)07J A 1 (-4.7A)07J A 1 (-4.7A)07J A 1 (-3.8A)07J A 1 (-3.2A) | 0.90A | 5zv2A-3tt0A:41.6 | 5zv2A-3tt0A:59.85 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3tt0 | BASIC FIBROBLASTGROWTH FACTORRECEPTOR 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 10 | LEU A 484VAL A 492ALA A 512GLU A 531MET A 535VAL A 561TYR A 563ALA A 564GLY A 567ALA A 640 | 07J A 1 ( 4.3A)07J A 1 (-4.0A)07J A 1 (-3.5A)07J A 1 (-3.8A)07J A 1 (-3.8A)07J A 1 (-4.7A)07J A 1 (-4.7A)07J A 1 (-3.8A)07J A 1 (-3.7A)07J A 1 (-3.2A) | 0.36A | 5zv2A-3tt0A:41.6 | 5zv2A-3tt0A:59.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3txo | PROTEIN KINASE C ETATYPE (Homo sapiens) |
PF00069(Pkinase)PF00433(Pkinase_C) | 6 | LEU A 361VAL A 369ALA A 382GLU A 403GLY A 439ALA A 496 | 07U A 1 ( 4.8A)07U A 1 (-4.8A)07U A 1 (-3.3A)07U A 1 ( 4.8A)None07U A 1 ( 4.0A) | 0.79A | 5zv2A-3txoA:13.8 | 5zv2A-3txoA:11.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vid | VASCULAR ENDOTHELIALGROWTH FACTORRECEPTOR 2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A 840VAL A 848ALA A 866GLU A 885VAL A 916GLY A 922 | 4TT A2001 ( 4.0A)4TT A2001 ( 4.5A)4TT A2001 (-3.5A)NoneNone4TT A2001 (-3.7A) | 0.29A | 5zv2A-3vidA:29.2 | 5zv2A-3vidA:15.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w18 | AURORA KINASE A (Homo sapiens) |
PF00069(Pkinase) | 7 | LEU A 139VAL A 147ALA A 160TYR A 212ALA A 213GLY A 216ALA A 273 | N13 A 501 (-3.7A)N13 A 501 ( 4.7A)N13 A 501 ( 4.1A)N13 A 501 (-4.4A)N13 A 501 (-3.7A)N13 A 501 (-3.5A)N13 A 501 ( 3.8A) | 0.39A | 5zv2A-3w18A:22.3 | 5zv2A-3w18A:13.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wzd | VASCULAR ENDOTHELIALGROWTH FACTORRECEPTOR 2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | LEU A 840GLY A 841VAL A 848ALA A 866GLU A 885VAL A 916GLY A 922 | LEV A1201 ( 3.8A)LEV A1201 (-3.1A)LEV A1201 ( 4.9A)LEV A1201 (-3.5A)LEV A1201 (-3.7A)LEV A1201 ( 4.6A)LEV A1201 (-3.6A) | 0.37A | 5zv2A-3wzdA:30.1 | 5zv2A-3wzdA:16.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4af3 | AURORA KINASE B (Homo sapiens) |
PF00069(Pkinase) | 7 | LEU A 83GLY A 84PHE A 88VAL A 91TYR A 156ALA A 157GLY A 160 | VX6 A 500 (-3.8A)VX6 A 500 ( 4.1A)VX6 A 500 (-3.4A)VX6 A 500 ( 4.8A)VX6 A 500 (-4.2A)VX6 A 500 (-3.7A)VX6 A 500 (-3.3A) | 1.19A | 5zv2A-4af3A:20.1 | 5zv2A-4af3A:13.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4af3 | AURORA KINASE B (Homo sapiens) |
PF00069(Pkinase) | 8 | LEU A 83GLY A 84VAL A 91ALA A 104TYR A 156ALA A 157GLY A 160ALA A 217 | VX6 A 500 (-3.8A)VX6 A 500 ( 4.1A)VX6 A 500 ( 4.8A)VX6 A 500 (-3.4A)VX6 A 500 (-4.2A)VX6 A 500 (-3.7A)VX6 A 500 (-3.3A)VX6 A 500 ( 4.2A) | 0.80A | 5zv2A-4af3A:20.1 | 5zv2A-4af3A:13.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4agd | VASCULAR ENDOTHELIALGROWTH FACTORRECEPTOR 2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | LEU A 840GLY A 841PHE A1047ALA A 866GLU A 885VAL A 916GLY A 922 | B49 A2000 (-3.7A)B49 A2000 ( 4.6A)B49 A2000 (-4.0A)B49 A2000 (-3.5A)NoneB49 A2000 (-4.8A)B49 A2000 ( 3.7A) | 1.22A | 5zv2A-4agdA:34.0 | 5zv2A-4agdA:15.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4agd | VASCULAR ENDOTHELIALGROWTH FACTORRECEPTOR 2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | LEU A 840PHE A1047VAL A 848ALA A 866GLU A 885VAL A 916GLY A 922 | B49 A2000 (-3.7A)B49 A2000 (-4.0A)NoneB49 A2000 (-3.5A)NoneB49 A2000 (-4.8A)B49 A2000 ( 3.7A) | 0.84A | 5zv2A-4agdA:34.0 | 5zv2A-4agdA:15.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4at3 | BDNF/NT-3 GROWTHFACTORS RECEPTOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A 560GLY A 561PHE A 565VAL A 568ALA A 586GLY A 639 | LTI A1839 ( 4.2A)LTI A1839 ( 4.3A)LTI A1839 (-3.5A)NoneLTI A1839 (-3.3A)LTI A1839 (-3.4A) | 0.60A | 5zv2A-4at3A:32.0 | 5zv2A-4at3A:12.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4at3 | BDNF/NT-3 GROWTHFACTORS RECEPTOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A 560GLY A 561VAL A 568ALA A 586TYR A 635GLY A 639 | LTI A1839 ( 4.2A)LTI A1839 ( 4.3A)NoneLTI A1839 (-3.3A)LTI A1839 (-4.7A)LTI A1839 (-3.4A) | 0.60A | 5zv2A-4at3A:32.0 | 5zv2A-4at3A:12.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aw2 | SERINE/THREONINE-PROTEIN KINASE MRCKALPHA (Rattusnorvegicus) |
PF00069(Pkinase)PF00433(Pkinase_C) | 6 | VAL A 91ALA A 104GLU A 125TYR A 156GLY A 160ALA A 218 | NoneEDO A1420 (-3.4A)EDO A1419 (-3.0A)EDO A1420 (-4.9A)NoneNone | 0.63A | 5zv2A-4aw2A:19.1 | 5zv2A-4aw2A:12.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c0t | LIKELY PROTEINKINASE (Candidaalbicans) |
PF00069(Pkinase) | 7 | LEU A 246GLY A 247VAL A 254ALA A 267GLU A 288TYR A 320ALA A 321 | None | 0.92A | 5zv2A-4c0tA:22.8 | 5zv2A-4c0tA:5.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c0t | LIKELY PROTEINKINASE (Candidaalbicans) |
PF00069(Pkinase) | 7 | LEU A 246VAL A 254ALA A 267GLU A 288TYR A 320ALA A 321GLY A 324 | None | 0.50A | 5zv2A-4c0tA:22.8 | 5zv2A-4c0tA:5.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cfh | 5'-AMP-ACTIVATEDPROTEIN KINASECATALYTIC SUBUNITALPHA-1 (Rattusnorvegicus) |
PF00069(Pkinase)PF16579(AdenylateSensor) | 6 | LEU A 22VAL A 30ALA A 43TYR A 95GLY A 99ALA A 156 | STU A1550 (-4.3A)NoneSTU A1550 (-3.1A)STU A1550 (-4.5A)STU A1550 (-3.4A)STU A1550 ( 3.8A) | 0.75A | 5zv2A-4cfhA:22.9 | 5zv2A-4cfhA:10.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ckr | EPITHELIAL DISCOIDINDOMAIN-CONTAININGRECEPTOR 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | LEU A 616GLY A 617ALA A 653GLU A 672MET A 676TYR A 703ALA A 783 | NoneNoneDI1 A1000 (-3.6A)DI1 A1000 (-3.8A)DI1 A1000 (-3.6A)DI1 A1000 (-4.0A)DI1 A1000 (-3.7A) | 1.38A | 5zv2A-4ckrA:29.8 | 5zv2A-4ckrA:16.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ckr | EPITHELIAL DISCOIDINDOMAIN-CONTAININGRECEPTOR 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 8 | LEU A 616PHE A 785VAL A 624ALA A 653GLU A 672MET A 676TYR A 703ALA A 783 | NoneDI1 A1000 (-4.5A)DI1 A1000 (-4.8A)DI1 A1000 (-3.6A)DI1 A1000 (-3.8A)DI1 A1000 (-3.6A)DI1 A1000 (-4.0A)DI1 A1000 (-3.7A) | 0.99A | 5zv2A-4ckrA:29.8 | 5zv2A-4ckrA:16.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ckr | EPITHELIAL DISCOIDINDOMAIN-CONTAININGRECEPTOR 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 8 | PHE A 785VAL A 624ALA A 653GLU A 672MET A 676TYR A 703GLY A 707ALA A 783 | DI1 A1000 (-4.5A)DI1 A1000 (-4.8A)DI1 A1000 (-3.6A)DI1 A1000 (-3.8A)DI1 A1000 (-3.6A)DI1 A1000 (-4.0A)NoneDI1 A1000 (-3.7A) | 0.97A | 5zv2A-4ckrA:29.8 | 5zv2A-4ckrA:16.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4crs | SERINE/THREONINE-PROTEIN KINASE N2 (Homo sapiens) |
PF00069(Pkinase)PF00433(Pkinase_C) | 8 | LEU A 663VAL A 671ALA A 684GLU A 705TYR A 739ALA A 740GLY A 743ALA A 799 | AGS A1985 (-4.2A)AGS A1985 (-4.6A)AGS A1985 (-3.5A)NoneNoneAGS A1985 (-3.9A)NoneAGS A1985 ( 4.5A) | 0.64A | 5zv2A-4crsA:15.8 | 5zv2A-4crsA:11.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gv1 | RAC-ALPHASERINE/THREONINE-PROTEIN KINASE (Homo sapiens) |
PF00069(Pkinase)PF00433(Pkinase_C) | 7 | LEU A 156VAL A 164ALA A 177GLU A 198TYR A 229ALA A 230GLY A 233 | 0XZ A 501 ( 4.1A)0XZ A 501 (-4.5A)0XZ A 501 (-3.3A)GOL A 503 (-3.6A)0XZ A 501 ( 4.9A)0XZ A 501 (-3.7A)None | 0.59A | 5zv2A-4gv1A:20.7 | 5zv2A-4gv1A:13.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hvi | TYROSINE-PROTEINKINASE JAK3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | LEU A 828VAL A 836ALA A 853GLU A 871TYR A 904GLY A 908ALA A 966 | 19S A1201 (-3.9A)19S A1201 (-4.4A)19S A1201 (-3.3A)None19S A1201 (-4.7A)19S A1201 ( 3.8A)19S A1201 ( 4.1A) | 0.57A | 5zv2A-4hviA:29.7 | 5zv2A-4hviA:16.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k11 | PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC (Homo sapiens) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 6 | LEU A 273VAL A 281ALA A 293TYR A 340GLY A 344ALA A 403 | 0J9 A 601 (-4.0A)0J9 A 601 (-4.4A)0J9 A 601 (-3.3A)0J9 A 601 ( 4.7A)0J9 A 601 ( 4.1A)0J9 A 601 (-3.5A) | 0.67A | 5zv2A-4k11A:29.5 | 5zv2A-4k11A:10.98 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4k33 | FIBROBLAST GROWTHFACTOR RECEPTOR 3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 10 | LEU A 478GLY A 479ALA A 506GLU A 525MET A 529VAL A 555TYR A 557ALA A 558GLY A 561ALA A 634 | ACP A 801 (-3.8A)ACP A 801 (-3.4A)ACP A 801 (-3.3A)ACP A 801 ( 4.8A)NoneACP A 801 (-4.7A)NoneACP A 801 (-3.7A)ACP A 801 ( 4.6A)None | 0.83A | 5zv2A-4k33A:29.9 | 5zv2A-4k33A:66.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4k33 | FIBROBLAST GROWTHFACTOR RECEPTOR 3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 10 | LEU A 478VAL A 486ALA A 506GLU A 525MET A 529VAL A 555TYR A 557ALA A 558GLY A 561ALA A 634 | ACP A 801 (-3.8A)ACP A 801 (-4.2A)ACP A 801 (-3.3A)ACP A 801 ( 4.8A)NoneACP A 801 (-4.7A)NoneACP A 801 (-3.7A)ACP A 801 ( 4.6A)None | 0.69A | 5zv2A-4k33A:29.9 | 5zv2A-4k33A:66.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l52 | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE 7,TGF-BETA-ACTIVATEDKINASE 1 ANDMAP3K7-BINDINGPROTEIN 1 CHIMERA (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | VAL A 50ALA A 61GLU A 77TYR A 106ALA A 107GLY A 110 | 1UL A 501 ( 4.9A)1UL A 501 (-3.1A)None1UL A 501 (-4.1A)1UL A 501 (-3.6A)1UL A 501 ( 3.7A) | 0.67A | 5zv2A-4l52A:20.7 | 5zv2A-4l52A:13.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lg4 | SERINE/THREONINE-PROTEIN KINASE 3 (Homo sapiens) |
PF00069(Pkinase) | 6 | LEU A 33VAL A 41ALA A 54MET A 74TYR A 101ALA A 163 | GOL A 404 ( 3.6A)GOL A 404 (-4.5A)GOL A 404 ( 3.1A)NoneGOL A 404 ( 4.9A)GOL A 403 ( 3.0A) | 0.70A | 5zv2A-4lg4A:20.3 | 5zv2A-4lg4A:15.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lg4 | SERINE/THREONINE-PROTEIN KINASE 3 (Homo sapiens) |
PF00069(Pkinase) | 6 | LEU A 33VAL A 41ALA A 54TYR A 101GLY A 105ALA A 163 | GOL A 404 ( 3.6A)GOL A 404 (-4.5A)GOL A 404 ( 3.1A)GOL A 404 ( 4.9A)GOL A 404 (-3.6A)GOL A 403 ( 3.0A) | 0.68A | 5zv2A-4lg4A:20.3 | 5zv2A-4lg4A:15.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lgg | PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC (Gallus gallus) |
PF07714(Pkinase_Tyr) | 7 | LEU A 273VAL A 281ALA A 293MET A 314TYR A 340GLY A 344ALA A 403 | VGG A 601 (-3.2A)VGG A 601 ( 3.5A)VGG A 601 (-3.5A)VGG A 601 ( 3.6A)VGG A 601 ( 4.0A)VGG A 601 ( 3.2A)VGG A 601 ( 4.2A) | 0.92A | 5zv2A-4lggA:28.5 | 5zv2A-4lggA:13.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o27 | SERINE/THREONINE-PROTEIN KINASE 24 (Homo sapiens) |
PF00069(Pkinase) | 6 | VAL B 38ALA B 51GLU B 70TYR B 101GLY B 105ALA B 161 | ADP B 500 (-4.5A)ADP B 500 (-3.3A)NoneADP B 500 ( 4.7A)NoneNone | 0.53A | 5zv2A-4o27B:20.1 | 5zv2A-4o27B:13.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oli | NON-RECEPTORTYROSINE-PROTEINKINASE TYK2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A 903VAL A 911ALA A 928GLU A 947TYR A 980GLY A 984 | 2TT A1202 (-3.5A)2TT A1202 (-4.5A)2TT A1202 ( 3.9A)None2TT A1202 (-4.6A)2TT A1202 (-3.4A) | 0.69A | 5zv2A-4oliA:27.6 | 5zv2A-4oliA:7.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q9z | HUMAN PROTEIN KINASEC THETA (Homo sapiens) |
PF00069(Pkinase)PF00433(Pkinase_C) | 7 | LEU A 386VAL A 394ALA A 407GLU A 428TYR A 460GLY A 464ALA A 521 | PZW A 801 (-3.9A)PZW A 801 (-4.6A)PZW A 801 (-3.5A)NoneNoneNonePZW A 801 ( 4.6A) | 0.76A | 5zv2A-4q9zA:12.0 | 5zv2A-4q9zA:11.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rt7 | RECEPTOR-TYPETYROSINE-PROTEINKINASE FLT3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | LEU A 616GLY A 617PHE A 830ALA A 642GLU A 661TYR A 693GLY A 697 | P30 A1001 (-3.8A)NoneP30 A1001 (-3.9A)P30 A1001 (-3.4A)P30 A1001 (-3.6A)P30 A1001 (-4.1A)P30 A1001 (-3.4A) | 1.16A | 5zv2A-4rt7A:28.9 | 5zv2A-4rt7A:12.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rt7 | RECEPTOR-TYPETYROSINE-PROTEINKINASE FLT3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | LEU A 616PHE A 830VAL A 624ALA A 642GLU A 661TYR A 693GLY A 697 | P30 A1001 (-3.8A)P30 A1001 (-3.9A)NoneP30 A1001 (-3.4A)P30 A1001 (-3.6A)P30 A1001 (-4.1A)P30 A1001 (-3.4A) | 0.75A | 5zv2A-4rt7A:28.9 | 5zv2A-4rt7A:12.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ueu | TYROSINE KINASE AS -A COMMON ANCESTOR OFSRC AND ABL (syntheticconstruct) |
PF07714(Pkinase_Tyr) | 7 | LEU A 14GLY A 15ALA A 35GLU A 52MET A 56TYR A 83ALA A 146 | ACP A1264 ( 4.5A)ACP A1264 ( 4.2A)ACP A1264 (-2.9A)NoneNoneACP A1264 ( 4.5A)None | 1.25A | 5zv2A-4ueuA:30.5 | 5zv2A-4ueuA:16.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ueu | TYROSINE KINASE AS -A COMMON ANCESTOR OFSRC AND ABL (syntheticconstruct) |
PF07714(Pkinase_Tyr) | 7 | LEU A 14VAL A 22ALA A 35GLU A 52MET A 56TYR A 83ALA A 146 | ACP A1264 ( 4.5A)ACP A1264 (-4.7A)ACP A1264 (-2.9A)NoneNoneACP A1264 ( 4.5A)None | 0.76A | 5zv2A-4ueuA:30.5 | 5zv2A-4ueuA:16.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ueu | TYROSINE KINASE AS -A COMMON ANCESTOR OFSRC AND ABL (syntheticconstruct) |
PF07714(Pkinase_Tyr) | 7 | LEU A 14VAL A 22ALA A 35MET A 56TYR A 83GLY A 87ALA A 146 | ACP A1264 ( 4.5A)ACP A1264 (-4.7A)ACP A1264 (-2.9A)NoneACP A1264 ( 4.5A)ACP A1264 (-3.5A)None | 0.85A | 5zv2A-4ueuA:30.5 | 5zv2A-4ueuA:16.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wb7 | DNAJ HOMOLOGSUBFAMILY B MEMBER1,CAMP-DEPENDENTPROTEIN KINASECATALYTIC SUBUNITALPHA (Homo sapiens) |
PF00069(Pkinase)PF00226(DnaJ) | 6 | LEU A 104VAL A 112ALA A 125GLU A 146TYR A 177GLY A 181 | ATP A 501 ( 4.3A)ATP A 501 (-4.0A)ATP A 501 (-3.4A)NoneNoneNone | 0.50A | 5zv2A-4wb7A:20.5 | 5zv2A-4wb7A:14.37 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4xcu | FIBROBLAST GROWTHFACTOR RECEPTOR 4 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 8 | LEU A 473GLY A 474VAL A 481ALA A 501GLU A 520MET A 524VAL A 550ALA A 629 | 40M A1002 ( 4.6A)None40M A1002 ( 4.5A)40M A1002 ( 4.1A)40M A1002 (-3.7A)40M A1002 (-3.8A)40M A1002 (-4.7A)40M A1002 (-3.0A) | 1.00A | 5zv2A-4xcuA:38.4 | 5zv2A-4xcuA:65.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4xcu | FIBROBLAST GROWTHFACTOR RECEPTOR 4 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 9 | LEU A 473VAL A 481ALA A 501GLU A 520MET A 524VAL A 550ALA A 553GLY A 556ALA A 629 | 40M A1002 ( 4.6A)40M A1002 ( 4.5A)40M A1002 ( 4.1A)40M A1002 (-3.7A)40M A1002 (-3.8A)40M A1002 (-4.7A)40M A1002 (-3.7A)40M A1002 ( 3.7A)40M A1002 (-3.0A) | 0.52A | 5zv2A-4xcuA:38.4 | 5zv2A-4xcuA:65.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xey | TYROSINE-PROTEINKINASE ABL1 (Homo sapiens) |
no annotation | 6 | LEU B 267VAL B 275ALA B 288MET B 309GLY B 340ALA B 399 | 1N1 B 601 (-3.7A)1N1 B 601 ( 4.9A)1N1 B 601 (-3.5A)1N1 B 601 (-3.7A)1N1 B 601 (-3.5A)1N1 B 601 (-3.5A) | 0.77A | 5zv2A-4xeyB:31.7 | 5zv2A-4xeyB:13.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xuf | RECEPTOR-TYPETYROSINE-PROTEINKINASE FLT3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | GLY A 617PHE A 830VAL A 624ALA A 642GLU A 661MET A 665TYR A 693 | NoneP30 A1001 ( 4.1A)P30 A1001 ( 4.8A)P30 A1001 (-3.5A)P30 A1001 (-3.1A)P30 A1001 (-4.4A)P30 A1001 ( 4.4A) | 1.23A | 5zv2A-4xufA:32.7 | 5zv2A-4xufA:14.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xuf | RECEPTOR-TYPETYROSINE-PROTEINKINASE FLT3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | LEU A 616GLY A 617PHE A 830VAL A 624ALA A 642GLU A 661TYR A 693 | P30 A1001 (-4.0A)NoneP30 A1001 ( 4.1A)P30 A1001 ( 4.8A)P30 A1001 (-3.5A)P30 A1001 (-3.1A)P30 A1001 ( 4.4A) | 1.11A | 5zv2A-4xufA:32.7 | 5zv2A-4xufA:14.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xuf | RECEPTOR-TYPETYROSINE-PROTEINKINASE FLT3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | LEU A 616PHE A 830VAL A 624ALA A 642GLU A 661TYR A 693GLY A 697 | P30 A1001 (-4.0A)P30 A1001 ( 4.1A)P30 A1001 ( 4.8A)P30 A1001 (-3.5A)P30 A1001 (-3.1A)P30 A1001 ( 4.4A)P30 A1001 (-3.5A) | 0.80A | 5zv2A-4xufA:32.7 | 5zv2A-4xufA:14.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xuf | RECEPTOR-TYPETYROSINE-PROTEINKINASE FLT3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | PHE A 830VAL A 624ALA A 642GLU A 661MET A 665TYR A 693GLY A 697 | P30 A1001 ( 4.1A)P30 A1001 ( 4.8A)P30 A1001 (-3.5A)P30 A1001 (-3.1A)P30 A1001 (-4.4A)P30 A1001 ( 4.4A)P30 A1001 (-3.5A) | 0.90A | 5zv2A-4xufA:32.7 | 5zv2A-4xufA:14.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yff | SERINE/THREONINE-PROTEIN KINASE TNNI3K (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | VAL A 477ALA A 488GLU A 509TYR A 541GLY A 545ALA A 605 | None4CV A 801 (-3.5A)None4CV A 801 (-3.9A)4CV A 801 ( 4.0A)4CV A 801 ( 3.9A) | 0.76A | 5zv2A-4yffA:24.4 | 5zv2A-4yffA:12.66 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5a46 | FIBROBLAST GROWTHFACTOR RECEPTOR 1(FMS-RELATEDTYROSINE KINASE 2,PFEIFFER SYNDROME),ISOFORM CRA_B (Homo sapiens) |
PF07714(Pkinase_Tyr) | 9 | LEU A 484GLY A 485ALA A 512GLU A 531MET A 535VAL A 561TYR A 563ALA A 564ALA A 640 | 38O A1769 (-3.2A)38O A1769 ( 4.7A)38O A1769 (-3.6A)EDO A1766 (-4.1A)EDO A1766 (-3.5A)38O A1769 (-4.3A)38O A1769 (-4.2A)38O A1769 (-3.9A)EDO A1766 ( 4.4A) | 0.99A | 5zv2A-5a46A:42.0 | 5zv2A-5a46A:78.22 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5a46 | FIBROBLAST GROWTHFACTOR RECEPTOR 1(FMS-RELATEDTYROSINE KINASE 2,PFEIFFER SYNDROME),ISOFORM CRA_B (Homo sapiens) |
PF07714(Pkinase_Tyr) | 10 | LEU A 484VAL A 492ALA A 512GLU A 531MET A 535VAL A 561TYR A 563ALA A 564GLY A 567ALA A 640 | 38O A1769 (-3.2A)38O A1769 (-4.5A)38O A1769 (-3.6A)EDO A1766 (-4.1A)EDO A1766 (-3.5A)38O A1769 (-4.3A)38O A1769 (-4.2A)38O A1769 (-3.9A)38O A1769 (-3.4A)EDO A1766 ( 4.4A) | 0.42A | 5zv2A-5a46A:42.0 | 5zv2A-5a46A:78.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5es1 | MAP/MICROTUBULEAFFINITY-REGULATINGKINASE 4 (Homo sapiens) |
PF00069(Pkinase)PF00627(UBA) | 7 | VAL A 70ALA A 83GLU A 103TYR A 134ALA A 135GLY A 138ALA A 195 | 5RC A4000 (-4.6A)5RC A4000 (-3.6A)None5RC A4000 (-4.5A)5RC A4000 (-3.7A)5RC A4000 (-3.3A)5RC A4000 ( 3.9A) | 0.87A | 5zv2A-5es1A:22.4 | 5zv2A-5es1A:11.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eyk | AURORA KINASE B-A (Xenopus laevis) |
PF00069(Pkinase) | 6 | LEU A 99VAL A 107ALA A 120ALA A 173GLY A 176ALA A 233 | 5U5 A 401 (-3.8A)5U5 A 401 ( 4.3A)5U5 A 401 (-3.5A)5U5 A 401 (-3.9A)5U5 A 401 (-3.4A)None | 0.56A | 5zv2A-5eykA:18.9 | 5zv2A-5eykA:14.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f1z | NON-RECEPTORTYROSINE-PROTEINKINASE TYK2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A 903VAL A 911ALA A 928GLU A 947TYR A 980GLY A 984 | 5U3 A1200 (-3.8A)5U3 A1200 ( 4.4A)5U3 A1200 (-3.5A)None5U3 A1200 (-4.5A)5U3 A1200 (-3.2A) | 0.55A | 5zv2A-5f1zA:28.6 | 5zv2A-5f1zA:15.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fm2 | PROTO-ONCOGENETYROSINE-PROTEINKINASE RECEPTOR RET (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | LEU A 730GLY A 731ALA A 756VAL A 804TYR A 806ALA A 807GLY A 810 | PP1 A2012 (-4.6A)PP1 A2012 ( 3.9A)PP1 A2012 (-3.2A)PP1 A2012 (-4.5A)NonePP1 A2012 ( 3.5A)PTR A 809 (-2.4A) | 0.75A | 5zv2A-5fm2A:34.7 | 5zv2A-5fm2A:13.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fm2 | PROTO-ONCOGENETYROSINE-PROTEINKINASE RECEPTOR RET (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A 730VAL A 738ALA A 756GLU A 775VAL A 804TYR A 806 | PP1 A2012 (-4.6A)PP1 A2012 (-4.4A)PP1 A2012 (-3.2A)PP1 A2012 (-3.5A)PP1 A2012 (-4.5A)None | 0.54A | 5zv2A-5fm2A:34.7 | 5zv2A-5fm2A:13.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fm2 | PROTO-ONCOGENETYROSINE-PROTEINKINASE RECEPTOR RET (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | LEU A 730VAL A 738ALA A 756VAL A 804TYR A 806ALA A 807GLY A 810 | PP1 A2012 (-4.6A)PP1 A2012 (-4.4A)PP1 A2012 (-3.2A)PP1 A2012 (-4.5A)NonePP1 A2012 ( 3.5A)PTR A 809 (-2.4A) | 0.58A | 5zv2A-5fm2A:34.7 | 5zv2A-5fm2A:13.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5grn | PLATELET-DERIVEDGROWTH FACTORRECEPTOR ALPHA (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | LEU A 599VAL A 607ALA A 625GLU A 644MET A 648TYR A 676GLY A 680 | 748 A1001 (-3.8A)748 A1001 ( 4.7A)748 A1001 (-3.7A)748 A1001 (-3.3A)748 A1001 (-3.4A)748 A1001 (-4.0A)748 A1001 ( 4.0A) | 0.64A | 5zv2A-5grnA:26.5 | 5zv2A-5grnA:17.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5grn | PLATELET-DERIVEDGROWTH FACTORRECEPTOR ALPHA (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | PHE A 837VAL A 607ALA A 625GLU A 644MET A 648TYR A 676GLY A 680 | 748 A1001 (-3.7A)748 A1001 ( 4.7A)748 A1001 (-3.7A)748 A1001 (-3.3A)748 A1001 (-3.4A)748 A1001 (-4.0A)748 A1001 ( 4.0A) | 0.95A | 5zv2A-5grnA:26.5 | 5zv2A-5grnA:17.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hu3 | CALCIUM/CALMODULIN-DEPENDENT PROTEINKINASE TYPE II ALPHACHAIN (Drosophilamelanogaster) |
PF00069(Pkinase) | 6 | LEU A 20VAL A 28ALA A 41GLU A 61GLY A 96ALA A 156 | ADP A 301 ( 4.0A)ADP A 301 (-3.7A)ADP A 301 (-3.5A)NoneNoneADP A 301 ( 4.8A) | 0.67A | 5zv2A-5hu3A:23.1 | 5zv2A-5hu3A:14.39 |