SIMILAR PATTERNS OF AMINO ACIDS FOR 5ZV2_A_LEVA801

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 VAL A 209
ALA A 220
GLU A 236
MET A 240
TYR A 268
GLY A 272
 None
 0.62A 5zv2A-1k9aA:
30.7		 5zv2A-1k9aA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 LEU A 267
GLY A 268
VAL A 275
ALA A 288
GLU A 305
MET A 309
GLY A 340
ALA A 399
 P16  A   2 ( 4.2A)
P16  A   2 ( 4.3A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 (-3.4A)
P16  A   2 (-3.5A)
 0.50A 5zv2A-1opkA:
31.5		 5zv2A-1opkA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pem RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 2
ALPHA CHAIN

(Salmonella
enterica) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF08343
(RNR_N) 		7 LEU A 286
GLY A 255
PHE A 209
VAL A 257
VAL A 234
ALA A 241
ALA A 193
 None
 1.47A 5zv2A-1pemA:
undetectable		 5zv2A-1pemA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
GLY A 617
VAL A 624
ALA A 642
GLU A 661
TYR A 693
GLY A 697
 None
 0.88A 5zv2A-1rjbA:
32.7		 5zv2A-1rjbA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 595
VAL A 603
ALA A 621
GLU A 640
TYR A 672
GLY A 676
 STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 ( 4.0A)
STI  A   3 ( 3.8A)
 0.45A 5zv2A-1t46A:
28.7		 5zv2A-1t46A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 344
VAL A 352
ALA A 367
GLU A 386
MET A 390
ALA A 417
GLY A 420
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
None
STU  A 100 (-3.7A)
STU  A 100 (-3.5A)
 0.47A 5zv2A-1u59A:
30.1		 5zv2A-1u59A:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  15
VAL A  23
ALA A  36
GLU A  55
TYR A  86
GLY A  90
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
None
HYM  A 400 (-4.7A)
None
 0.44A 5zv2A-1zltA:
21.3		 5zv2A-1zltA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU X  17
GLY X  18
ALA X  37
GLU X  54
MET X  58
TYR X  84
ALA X 147
 STU  X 902 (-3.8A)
STU  X 902 ( 3.7A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
None
STU  X 902 (-4.6A)
STU  X 902 ( 4.1A)
 1.08A 5zv2A-2dq7X:
30.7		 5zv2A-2dq7X:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU X  17
VAL X  25
ALA X  37
GLU X  54
MET X  58
TYR X  84
GLY X  88
ALA X 147
 STU  X 902 (-3.8A)
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
None
STU  X 902 (-4.6A)
STU  X 902 (-3.5A)
STU  X 902 ( 4.1A)
 0.62A 5zv2A-2dq7X:
30.7		 5zv2A-2dq7X:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 LEU A 273
VAL A 281
ALA A 293
TYR A 340
GLY A 344
ALA A 403
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-4.3A)
H8H  A 534 (-3.3A)
H8H  A 534 ( 4.0A)
 0.63A 5zv2A-2h8hA:
29.6		 5zv2A-2h8hA:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hak SERINE/THREONINE-PRO
TEIN KINASE MARK1

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		7 VAL A  67
ALA A  80
MET A 104
TYR A 131
ALA A 132
GLY A 135
ALA A 192
 None
 0.96A 5zv2A-2hakA:
20.5		 5zv2A-2hakA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 251
VAL A 259
ALA A 271
GLU A 288
MET A 292
GLY A 322
ALA A 381
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.5A)
1BM  A 499 ( 3.7A)
 1.05A 5zv2A-2hk5A:
25.2		 5zv2A-2hk5A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 248
VAL A 256
ALA A 269
GLU A 286
MET A 290
GLY A 321
ALA A 380
 GIN  A 600 ( 4.6A)
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.2A)
None
GIN  A 600 (-3.1A)
 0.67A 5zv2A-2hz0A:
30.0		 5zv2A-2hz0A:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0e PROTEIN KINASE
C-BETA II

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 LEU A 348
VAL A 356
ALA A 369
GLU A 390
TYR A 422
ALA A 483
 PDS  A 901 (-3.9A)
PDS  A 901 (-4.2A)
PDS  A 901 (-3.3A)
None
PDS  A 901 (-4.7A)
PDS  A 901 (-3.4A)
 0.70A 5zv2A-2i0eA:
9.0		 5zv2A-2i0eA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 251
PHE A 383
VAL A 259
ALA A 271
GLU A 288
MET A 292
GLY A 322
ALA A 381
 None
1N8  A 501 ( 4.3A)
None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.5A)
1N8  A 501 ( 3.3A)
 0.88A 5zv2A-2og8A:
30.0		 5zv2A-2og8A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 251
VAL A 259
ALA A 271
GLU A 288
MET A 292
TYR A 318
GLY A 322
ALA A 381
 None
None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.7A)
1N8  A 501 ( 3.5A)
1N8  A 501 ( 3.3A)
 0.73A 5zv2A-2og8A:
30.0		 5zv2A-2og8A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 588
GLY A 589
ALA A 614
GLU A 633
MET A 637
TYR A 665
GLY A 669
 None
 0.96A 5zv2A-2ogvA:
32.5		 5zv2A-2ogvA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 588
VAL A 596
ALA A 614
GLU A 633
MET A 637
TYR A 665
GLY A 669
 None
 0.58A 5zv2A-2ogvA:
32.5		 5zv2A-2ogvA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4i ANGIOPOIETIN-1
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 838
ALA A 853
TYR A 904
ALA A 905
GLY A 908
ALA A 981
 MR9  A 301 (-4.6A)
MR9  A 301 (-3.5A)
MR9  A 301 (-3.8A)
MR9  A 301 (-3.6A)
MR9  A 301 ( 3.8A)
MR9  A 301 (-3.2A)
 0.69A 5zv2A-2p4iA:
25.1		 5zv2A-2p4iA:
12.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		11 LEU A 487
GLY A 488
VAL A 495
ALA A 515
GLU A 534
MET A 538
VAL A 564
TYR A 566
ALA A 567
GLY A 570
ALA A 643
 None
 0.53A 5zv2A-2psqA:
36.8		 5zv2A-2psqA:
45.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd5 DMPK PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  85
ALA A  98
GLU A 119
TYR A 150
GLY A 154
ALA A 212
 BI8  A1417 ( 4.7A)
BI8  A1417 ( 3.8A)
BI8  A1417 ( 4.9A)
BI8  A1417 (-4.8A)
None
BI8  A1417 ( 4.1A)
 0.77A 5zv2A-2vd5A:
19.5		 5zv2A-2vd5A:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4f MYOSIN LIGHT CHAIN
KINASE FAMILY MEMBER
4

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A 112
VAL A 120
ALA A 133
MET A 155
TYR A 182
GLY A 186
 16X  A1374 (-4.1A)
16X  A1374 (-4.8A)
16X  A1374 ( 3.8A)
None
16X  A1374 (-4.1A)
16X  A1374 (-4.0A)
 0.58A 5zv2A-2x4fA:
22.3		 5zv2A-2x4fA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xik SERINE/THREONINE
PROTEIN KINASE 25

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  27
ALA A  47
GLU A  66
TYR A  97
GLY A 101
ALA A 157
 J60  A1294 ( 4.1A)
J60  A1294 (-3.3A)
None
J60  A1294 (-4.5A)
J60  A1294 ( 3.8A)
J60  A1294 ( 4.2A)
 0.77A 5zv2A-2xikA:
18.8		 5zv2A-2xikA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xik SERINE/THREONINE
PROTEIN KINASE 25

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  34
ALA A  47
GLU A  66
TYR A  97
GLY A 101
ALA A 157
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
J60  A1294 (-4.5A)
J60  A1294 ( 3.8A)
J60  A1294 ( 4.2A)
 0.57A 5zv2A-2xikA:
18.8		 5zv2A-2xikA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8c INSULIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A1002
VAL A1010
ALA A1028
GLU A1047
MET A1051
GLY A1082
 S91  A   1 ( 4.1A)
S91  A   1 ( 4.9A)
S91  A   1 (-3.2A)
None
None
S91  A   1 (-3.3A)
 0.69A 5zv2A-2z8cA:
22.6		 5zv2A-2z8cA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  97
VAL A 105
ALA A 121
GLU A 143
TYR A 174
GLY A 178
 STU  A 400 (-3.8A)
STU  A 400 (-4.9A)
STU  A 400 (-3.1A)
STU  A 400 ( 4.3A)
STU  A 400 (-4.7A)
STU  A 400 ( 4.4A)
 0.47A 5zv2A-3a62A:
18.3		 5zv2A-3a62A:
13.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 487
GLY A 488
VAL A 495
ALA A 515
GLU A 534
MET A 538
VAL A 564
TYR A 566
ALA A 567
 M33  A1996 (-4.0A)
M33  A1996 ( 3.8A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
None
None
M33  A1996 ( 4.7A)
M33  A1996 (-3.8A)
 1.02A 5zv2A-3b2tA:
28.6		 5zv2A-3b2tA:
75.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 487
GLY A 488
VAL A 495
ALA A 515
MET A 538
VAL A 564
TYR A 566
ALA A 567
ALA A 643
 M33  A1996 (-4.0A)
M33  A1996 ( 3.8A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
None
M33  A1996 ( 4.7A)
M33  A1996 (-3.8A)
None
 0.93A 5zv2A-3b2tA:
28.6		 5zv2A-3b2tA:
75.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 487
VAL A 495
ALA A 515
MET A 538
VAL A 564
TYR A 566
ALA A 567
GLY A 570
ALA A 643
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
None
M33  A1996 ( 4.7A)
M33  A1996 (-3.8A)
M33  A1996 ( 4.8A)
None
 0.46A 5zv2A-3b2tA:
28.6		 5zv2A-3b2tA:
75.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 487
PHE A 489
VAL A 492
GLU A 531
MET A 535
VAL A 561
ALA A 640
 None
C4F  A   1 (-3.7A)
None
None
C4F  A   1 ( 3.7A)
C4F  A   1 ( 4.8A)
C4F  A   1 (-3.6A)
 1.34A 5zv2A-3c4fA:
43.9		 5zv2A-3c4fA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		12 LEU A 484
GLY A 485
PHE A 489
VAL A 492
ALA A 512
GLU A 531
MET A 535
VAL A 561
TYR A 563
ALA A 564
GLY A 567
ALA A 640
 C4F  A   1 ( 3.9A)
C4F  A   1 ( 4.5A)
C4F  A   1 (-3.7A)
None
C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
C4F  A   1 ( 4.8A)
None
C4F  A   1 (-3.5A)
None
C4F  A   1 (-3.6A)
 0.50A 5zv2A-3c4fA:
43.9		 5zv2A-3c4fA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 209
ALA A 220
GLU A 236
MET A 240
TYR A 268
GLY A 272
 None
 0.62A 5zv2A-3d7uA:
25.8		 5zv2A-3d7uA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		6 LEU A  15
VAL A  23
ALA A  36
GLU A  50
MET A  54
TYR A 119
 DRK  A 384 (-3.8A)
None
DRK  A 384 (-3.5A)
None
None
DRK  A 384 (-4.4A)
 0.55A 5zv2A-3eb0A:
20.5		 5zv2A-3eb0A:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fe3 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 3

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		7 VAL A  70
ALA A  83
MET A 107
TYR A 134
ALA A 135
GLY A 138
ALA A 195
 None
 0.83A 5zv2A-3fe3A:
19.0		 5zv2A-3fe3A:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 833
VAL A 841
ALA A 859
GLU A 878
VAL A 909
TYR A 911
GLY A 915
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
8ST  A2001 (-4.1A)
8ST  A2001 (-4.9A)
None
 0.23A 5zv2A-3hngA:
33.7		 5zv2A-3hngA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		7 VAL A  67
ALA A  80
MET A 104
TYR A 131
ALA A 132
GLY A 135
ALA A 192
 None
 0.71A 5zv2A-3iecA:
22.3		 5zv2A-3iecA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  39
VAL A  47
ALA A  60
GLU A  80
TYR A 112
ALA A 113
GLY A 116
 QUE  A   1 ( 3.8A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-3.1A)
QUE  A   1 (-4.9A)
QUE  A   1 (-3.9A)
None
 0.67A 5zv2A-3lm5A:
23.5		 5zv2A-3lm5A:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		6 VAL A 218
ALA A 229
GLU A 244
TYR A 281
GLY A 285
ALA A 349
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.3A)
LDN  A   1 ( 3.8A)
 0.77A 5zv2A-3mdyA:
25.1		 5zv2A-3mdyA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  49
VAL A  57
ALA A  70
GLU A  91
TYR A 122
GLY A 126
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
None
 0.44A 5zv2A-3mvjA:
20.5		 5zv2A-3mvjA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  88
VAL A  96
ALA A 109
GLU A 130
MET A 134
TYR A 161
ALA A 162
GLY A 165
 JOZ  A 361 (-4.1A)
JOZ  A 361 ( 4.7A)
JOZ  A 361 (-3.4A)
SO4  A   5 (-3.1A)
None
None
JOZ  A 361 (-3.8A)
None
 0.56A 5zv2A-3nuuA:
23.1		 5zv2A-3nuuA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfv CDC42BPB PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  90
ALA A 103
GLU A 124
TYR A 155
GLY A 159
ALA A 217
 NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
EDO  A 417 (-4.0A)
NM7  A 416 (-4.4A)
None
NM7  A 416 ( 4.5A)
 0.76A 5zv2A-3qfvA:
18.5		 5zv2A-3qfvA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s95 LIM DOMAIN KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 345
GLU A 384
MET A 388
TYR A 415
GLY A 419
ALA A 477
 STU  A   1 (-3.8A)
STU  A   1 (-3.7A)
None
STU  A   1 (-4.7A)
STU  A   1 (-3.6A)
STU  A   1 ( 4.1A)
 0.80A 5zv2A-3s95A:
25.0		 5zv2A-3s95A:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 423
VAL A 431
ALA A 443
MET A 464
TYR A 491
GLY A 495
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
PP2  A   1 ( 4.9A)
PP2  A   1 ( 4.2A)
 0.72A 5zv2A-3sxsA:
30.5		 5zv2A-3sxsA:
14.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 484
GLY A 485
ALA A 512
GLU A 531
MET A 535
VAL A 561
TYR A 563
ALA A 564
ALA A 640
 07J  A   1 ( 4.3A)
07J  A   1 ( 4.9A)
07J  A   1 (-3.5A)
07J  A   1 (-3.8A)
07J  A   1 (-3.8A)
07J  A   1 (-4.7A)
07J  A   1 (-4.7A)
07J  A   1 (-3.8A)
07J  A   1 (-3.2A)
 0.90A 5zv2A-3tt0A:
41.6		 5zv2A-3tt0A:
59.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 484
VAL A 492
ALA A 512
GLU A 531
MET A 535
VAL A 561
TYR A 563
ALA A 564
GLY A 567
ALA A 640
 07J  A   1 ( 4.3A)
07J  A   1 (-4.0A)
07J  A   1 (-3.5A)
07J  A   1 (-3.8A)
07J  A   1 (-3.8A)
07J  A   1 (-4.7A)
07J  A   1 (-4.7A)
07J  A   1 (-3.8A)
07J  A   1 (-3.7A)
07J  A   1 (-3.2A)
 0.36A 5zv2A-3tt0A:
41.6		 5zv2A-3tt0A:
59.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 LEU A 361
VAL A 369
ALA A 382
GLU A 403
GLY A 439
ALA A 496
 07U  A   1 ( 4.8A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 ( 4.8A)
None
07U  A   1 ( 4.0A)
 0.79A 5zv2A-3txoA:
13.8		 5zv2A-3txoA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 840
VAL A 848
ALA A 866
GLU A 885
VAL A 916
GLY A 922
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
4TT  A2001 (-3.7A)
 0.29A 5zv2A-3vidA:
29.2		 5zv2A-3vidA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w18 AURORA KINASE A

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A 139
VAL A 147
ALA A 160
TYR A 212
ALA A 213
GLY A 216
ALA A 273
 N13  A 501 (-3.7A)
N13  A 501 ( 4.7A)
N13  A 501 ( 4.1A)
N13  A 501 (-4.4A)
N13  A 501 (-3.7A)
N13  A 501 (-3.5A)
N13  A 501 ( 3.8A)
 0.39A 5zv2A-3w18A:
22.3		 5zv2A-3w18A:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 840
GLY A 841
VAL A 848
ALA A 866
GLU A 885
VAL A 916
GLY A 922
 LEV  A1201 ( 3.8A)
LEV  A1201 (-3.1A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
LEV  A1201 ( 4.6A)
LEV  A1201 (-3.6A)
 0.37A 5zv2A-3wzdA:
30.1		 5zv2A-3wzdA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4af3 AURORA KINASE B

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  83
GLY A  84
PHE A  88
VAL A  91
TYR A 156
ALA A 157
GLY A 160
 VX6  A 500 (-3.8A)
VX6  A 500 ( 4.1A)
VX6  A 500 (-3.4A)
VX6  A 500 ( 4.8A)
VX6  A 500 (-4.2A)
VX6  A 500 (-3.7A)
VX6  A 500 (-3.3A)
 1.19A 5zv2A-4af3A:
20.1		 5zv2A-4af3A:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4af3 AURORA KINASE B

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  83
GLY A  84
VAL A  91
ALA A 104
TYR A 156
ALA A 157
GLY A 160
ALA A 217
 VX6  A 500 (-3.8A)
VX6  A 500 ( 4.1A)
VX6  A 500 ( 4.8A)
VX6  A 500 (-3.4A)
VX6  A 500 (-4.2A)
VX6  A 500 (-3.7A)
VX6  A 500 (-3.3A)
VX6  A 500 ( 4.2A)
 0.80A 5zv2A-4af3A:
20.1		 5zv2A-4af3A:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 840
GLY A 841
PHE A1047
ALA A 866
GLU A 885
VAL A 916
GLY A 922
 B49  A2000 (-3.7A)
B49  A2000 ( 4.6A)
B49  A2000 (-4.0A)
B49  A2000 (-3.5A)
None
B49  A2000 (-4.8A)
B49  A2000 ( 3.7A)
 1.22A 5zv2A-4agdA:
34.0		 5zv2A-4agdA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 840
PHE A1047
VAL A 848
ALA A 866
GLU A 885
VAL A 916
GLY A 922
 B49  A2000 (-3.7A)
B49  A2000 (-4.0A)
None
B49  A2000 (-3.5A)
None
B49  A2000 (-4.8A)
B49  A2000 ( 3.7A)
 0.84A 5zv2A-4agdA:
34.0		 5zv2A-4agdA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 560
GLY A 561
PHE A 565
VAL A 568
ALA A 586
GLY A 639
 LTI  A1839 ( 4.2A)
LTI  A1839 ( 4.3A)
LTI  A1839 (-3.5A)
None
LTI  A1839 (-3.3A)
LTI  A1839 (-3.4A)
 0.60A 5zv2A-4at3A:
32.0		 5zv2A-4at3A:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 560
GLY A 561
VAL A 568
ALA A 586
TYR A 635
GLY A 639
 LTI  A1839 ( 4.2A)
LTI  A1839 ( 4.3A)
None
LTI  A1839 (-3.3A)
LTI  A1839 (-4.7A)
LTI  A1839 (-3.4A)
 0.60A 5zv2A-4at3A:
32.0		 5zv2A-4at3A:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 VAL A  91
ALA A 104
GLU A 125
TYR A 156
GLY A 160
ALA A 218
 None
EDO  A1420 (-3.4A)
EDO  A1419 (-3.0A)
EDO  A1420 (-4.9A)
None
None
 0.63A 5zv2A-4aw2A:
19.1		 5zv2A-4aw2A:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		7 LEU A 246
GLY A 247
VAL A 254
ALA A 267
GLU A 288
TYR A 320
ALA A 321
 None
 0.92A 5zv2A-4c0tA:
22.8		 5zv2A-4c0tA:
5.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		7 LEU A 246
VAL A 254
ALA A 267
GLU A 288
TYR A 320
ALA A 321
GLY A 324
 None
 0.50A 5zv2A-4c0tA:
22.8		 5zv2A-4c0tA:
5.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		6 LEU A  22
VAL A  30
ALA A  43
TYR A  95
GLY A  99
ALA A 156
 STU  A1550 (-4.3A)
None
STU  A1550 (-3.1A)
STU  A1550 (-4.5A)
STU  A1550 (-3.4A)
STU  A1550 ( 3.8A)
 0.75A 5zv2A-4cfhA:
22.9		 5zv2A-4cfhA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
GLY A 617
ALA A 653
GLU A 672
MET A 676
TYR A 703
ALA A 783
 None
None
DI1  A1000 (-3.6A)
DI1  A1000 (-3.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-4.0A)
DI1  A1000 (-3.7A)
 1.38A 5zv2A-4ckrA:
29.8		 5zv2A-4ckrA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 616
PHE A 785
VAL A 624
ALA A 653
GLU A 672
MET A 676
TYR A 703
ALA A 783
 None
DI1  A1000 (-4.5A)
DI1  A1000 (-4.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-4.0A)
DI1  A1000 (-3.7A)
 0.99A 5zv2A-4ckrA:
29.8		 5zv2A-4ckrA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 PHE A 785
VAL A 624
ALA A 653
GLU A 672
MET A 676
TYR A 703
GLY A 707
ALA A 783
 DI1  A1000 (-4.5A)
DI1  A1000 (-4.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-4.0A)
None
DI1  A1000 (-3.7A)
 0.97A 5zv2A-4ckrA:
29.8		 5zv2A-4ckrA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		8 LEU A 663
VAL A 671
ALA A 684
GLU A 705
TYR A 739
ALA A 740
GLY A 743
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
AGS  A1985 (-3.9A)
None
AGS  A1985 ( 4.5A)
 0.64A 5zv2A-4crsA:
15.8		 5zv2A-4crsA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gv1 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 LEU A 156
VAL A 164
ALA A 177
GLU A 198
TYR A 229
ALA A 230
GLY A 233
 0XZ  A 501 ( 4.1A)
0XZ  A 501 (-4.5A)
0XZ  A 501 (-3.3A)
GOL  A 503 (-3.6A)
0XZ  A 501 ( 4.9A)
0XZ  A 501 (-3.7A)
None
 0.59A 5zv2A-4gv1A:
20.7		 5zv2A-4gv1A:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 828
VAL A 836
ALA A 853
GLU A 871
TYR A 904
GLY A 908
ALA A 966
 19S  A1201 (-3.9A)
19S  A1201 (-4.4A)
19S  A1201 (-3.3A)
None
19S  A1201 (-4.7A)
19S  A1201 ( 3.8A)
19S  A1201 ( 4.1A)
 0.57A 5zv2A-4hviA:
29.7		 5zv2A-4hviA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 LEU A 273
VAL A 281
ALA A 293
TYR A 340
GLY A 344
ALA A 403
 0J9  A 601 (-4.0A)
0J9  A 601 (-4.4A)
0J9  A 601 (-3.3A)
0J9  A 601 ( 4.7A)
0J9  A 601 ( 4.1A)
0J9  A 601 (-3.5A)
 0.67A 5zv2A-4k11A:
29.5		 5zv2A-4k11A:
10.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 478
GLY A 479
ALA A 506
GLU A 525
MET A 529
VAL A 555
TYR A 557
ALA A 558
GLY A 561
ALA A 634
 ACP  A 801 (-3.8A)
ACP  A 801 (-3.4A)
ACP  A 801 (-3.3A)
ACP  A 801 ( 4.8A)
None
ACP  A 801 (-4.7A)
None
ACP  A 801 (-3.7A)
ACP  A 801 ( 4.6A)
None
 0.83A 5zv2A-4k33A:
29.9		 5zv2A-4k33A:
66.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 478
VAL A 486
ALA A 506
GLU A 525
MET A 529
VAL A 555
TYR A 557
ALA A 558
GLY A 561
ALA A 634
 ACP  A 801 (-3.8A)
ACP  A 801 (-4.2A)
ACP  A 801 (-3.3A)
ACP  A 801 ( 4.8A)
None
ACP  A 801 (-4.7A)
None
ACP  A 801 (-3.7A)
ACP  A 801 ( 4.6A)
None
 0.69A 5zv2A-4k33A:
29.9		 5zv2A-4k33A:
66.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A  50
ALA A  61
GLU A  77
TYR A 106
ALA A 107
GLY A 110
 1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
None
1UL  A 501 (-4.1A)
1UL  A 501 (-3.6A)
1UL  A 501 ( 3.7A)
 0.67A 5zv2A-4l52A:
20.7		 5zv2A-4l52A:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  33
VAL A  41
ALA A  54
MET A  74
TYR A 101
ALA A 163
 GOL  A 404 ( 3.6A)
GOL  A 404 (-4.5A)
GOL  A 404 ( 3.1A)
None
GOL  A 404 ( 4.9A)
GOL  A 403 ( 3.0A)
 0.70A 5zv2A-4lg4A:
20.3		 5zv2A-4lg4A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  33
VAL A  41
ALA A  54
TYR A 101
GLY A 105
ALA A 163
 GOL  A 404 ( 3.6A)
GOL  A 404 (-4.5A)
GOL  A 404 ( 3.1A)
GOL  A 404 ( 4.9A)
GOL  A 404 (-3.6A)
GOL  A 403 ( 3.0A)
 0.68A 5zv2A-4lg4A:
20.3		 5zv2A-4lg4A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		7 LEU A 273
VAL A 281
ALA A 293
MET A 314
TYR A 340
GLY A 344
ALA A 403
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 3.6A)
VGG  A 601 ( 4.0A)
VGG  A 601 ( 3.2A)
VGG  A 601 ( 4.2A)
 0.92A 5zv2A-4lggA:
28.5		 5zv2A-4lggA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL B  38
ALA B  51
GLU B  70
TYR B 101
GLY B 105
ALA B 161
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
None
ADP  B 500 ( 4.7A)
None
None
 0.53A 5zv2A-4o27B:
20.1		 5zv2A-4o27B:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 903
VAL A 911
ALA A 928
GLU A 947
TYR A 980
GLY A 984
 2TT  A1202 (-3.5A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
None
2TT  A1202 (-4.6A)
2TT  A1202 (-3.4A)
 0.69A 5zv2A-4oliA:
27.6		 5zv2A-4oliA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9z HUMAN PROTEIN KINASE
C THETA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 LEU A 386
VAL A 394
ALA A 407
GLU A 428
TYR A 460
GLY A 464
ALA A 521
 PZW  A 801 (-3.9A)
PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
None
None
None
PZW  A 801 ( 4.6A)
 0.76A 5zv2A-4q9zA:
12.0		 5zv2A-4q9zA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
GLY A 617
PHE A 830
ALA A 642
GLU A 661
TYR A 693
GLY A 697
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.9A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 (-4.1A)
P30  A1001 (-3.4A)
 1.16A 5zv2A-4rt7A:
28.9		 5zv2A-4rt7A:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
PHE A 830
VAL A 624
ALA A 642
GLU A 661
TYR A 693
GLY A 697
 P30  A1001 (-3.8A)
P30  A1001 (-3.9A)
None
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 (-4.1A)
P30  A1001 (-3.4A)
 0.75A 5zv2A-4rt7A:
28.9		 5zv2A-4rt7A:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		7 LEU A  14
GLY A  15
ALA A  35
GLU A  52
MET A  56
TYR A  83
ALA A 146
 ACP  A1264 ( 4.5A)
ACP  A1264 ( 4.2A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 ( 4.5A)
None
 1.25A 5zv2A-4ueuA:
30.5		 5zv2A-4ueuA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		7 LEU A  14
VAL A  22
ALA A  35
GLU A  52
MET A  56
TYR A  83
ALA A 146
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 ( 4.5A)
None
 0.76A 5zv2A-4ueuA:
30.5		 5zv2A-4ueuA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		7 LEU A  14
VAL A  22
ALA A  35
MET A  56
TYR A  83
GLY A  87
ALA A 146
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
ACP  A1264 ( 4.5A)
ACP  A1264 (-3.5A)
None
 0.85A 5zv2A-4ueuA:
30.5		 5zv2A-4ueuA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase)
PF00226
(DnaJ) 		6 LEU A 104
VAL A 112
ALA A 125
GLU A 146
TYR A 177
GLY A 181
 ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
None
None
None
 0.50A 5zv2A-4wb7A:
20.5		 5zv2A-4wb7A:
14.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 473
GLY A 474
VAL A 481
ALA A 501
GLU A 520
MET A 524
VAL A 550
ALA A 629
 40M  A1002 ( 4.6A)
None
40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
40M  A1002 (-4.7A)
40M  A1002 (-3.0A)
 1.00A 5zv2A-4xcuA:
38.4		 5zv2A-4xcuA:
65.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 473
VAL A 481
ALA A 501
GLU A 520
MET A 524
VAL A 550
ALA A 553
GLY A 556
ALA A 629
 40M  A1002 ( 4.6A)
40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
40M  A1002 (-4.7A)
40M  A1002 (-3.7A)
40M  A1002 ( 3.7A)
40M  A1002 (-3.0A)
 0.52A 5zv2A-4xcuA:
38.4		 5zv2A-4xcuA:
65.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 6 LEU B 267
VAL B 275
ALA B 288
MET B 309
GLY B 340
ALA B 399
 1N1  B 601 (-3.7A)
1N1  B 601 ( 4.9A)
1N1  B 601 (-3.5A)
1N1  B 601 (-3.7A)
1N1  B 601 (-3.5A)
1N1  B 601 (-3.5A)
 0.77A 5zv2A-4xeyB:
31.7		 5zv2A-4xeyB:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 617
PHE A 830
VAL A 624
ALA A 642
GLU A 661
MET A 665
TYR A 693
 None
P30  A1001 ( 4.1A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 (-4.4A)
P30  A1001 ( 4.4A)
 1.23A 5zv2A-4xufA:
32.7		 5zv2A-4xufA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
GLY A 617
PHE A 830
VAL A 624
ALA A 642
GLU A 661
TYR A 693
 P30  A1001 (-4.0A)
None
P30  A1001 ( 4.1A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 ( 4.4A)
 1.11A 5zv2A-4xufA:
32.7		 5zv2A-4xufA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
PHE A 830
VAL A 624
ALA A 642
GLU A 661
TYR A 693
GLY A 697
 P30  A1001 (-4.0A)
P30  A1001 ( 4.1A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 ( 4.4A)
P30  A1001 (-3.5A)
 0.80A 5zv2A-4xufA:
32.7		 5zv2A-4xufA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 PHE A 830
VAL A 624
ALA A 642
GLU A 661
MET A 665
TYR A 693
GLY A 697
 P30  A1001 ( 4.1A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 (-4.4A)
P30  A1001 ( 4.4A)
P30  A1001 (-3.5A)
 0.90A 5zv2A-4xufA:
32.7		 5zv2A-4xufA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 477
ALA A 488
GLU A 509
TYR A 541
GLY A 545
ALA A 605
 None
4CV  A 801 (-3.5A)
None
4CV  A 801 (-3.9A)
4CV  A 801 ( 4.0A)
4CV  A 801 ( 3.9A)
 0.76A 5zv2A-4yffA:
24.4		 5zv2A-4yffA:
12.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 484
GLY A 485
ALA A 512
GLU A 531
MET A 535
VAL A 561
TYR A 563
ALA A 564
ALA A 640
 38O  A1769 (-3.2A)
38O  A1769 ( 4.7A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
38O  A1769 (-4.3A)
38O  A1769 (-4.2A)
38O  A1769 (-3.9A)
EDO  A1766 ( 4.4A)
 0.99A 5zv2A-5a46A:
42.0		 5zv2A-5a46A:
78.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 484
VAL A 492
ALA A 512
GLU A 531
MET A 535
VAL A 561
TYR A 563
ALA A 564
GLY A 567
ALA A 640
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
38O  A1769 (-4.3A)
38O  A1769 (-4.2A)
38O  A1769 (-3.9A)
38O  A1769 (-3.4A)
EDO  A1766 ( 4.4A)
 0.42A 5zv2A-5a46A:
42.0		 5zv2A-5a46A:
78.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		7 VAL A  70
ALA A  83
GLU A 103
TYR A 134
ALA A 135
GLY A 138
ALA A 195
 5RC  A4000 (-4.6A)
5RC  A4000 (-3.6A)
None
5RC  A4000 (-4.5A)
5RC  A4000 (-3.7A)
5RC  A4000 (-3.3A)
5RC  A4000 ( 3.9A)
 0.87A 5zv2A-5es1A:
22.4		 5zv2A-5es1A:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyk AURORA KINASE B-A

(Xenopus laevis) 		PF00069
(Pkinase) 		6 LEU A  99
VAL A 107
ALA A 120
ALA A 173
GLY A 176
ALA A 233
 5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-3.9A)
5U5  A 401 (-3.4A)
None
 0.56A 5zv2A-5eykA:
18.9		 5zv2A-5eykA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 903
VAL A 911
ALA A 928
GLU A 947
TYR A 980
GLY A 984
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
5U3  A1200 (-4.5A)
5U3  A1200 (-3.2A)
 0.55A 5zv2A-5f1zA:
28.6		 5zv2A-5f1zA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 730
GLY A 731
ALA A 756
VAL A 804
TYR A 806
ALA A 807
GLY A 810
 PP1  A2012 (-4.6A)
PP1  A2012 ( 3.9A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.5A)
None
PP1  A2012 ( 3.5A)
PTR  A 809 (-2.4A)
 0.75A 5zv2A-5fm2A:
34.7		 5zv2A-5fm2A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 730
VAL A 738
ALA A 756
GLU A 775
VAL A 804
TYR A 806
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-3.5A)
PP1  A2012 (-4.5A)
None
 0.54A 5zv2A-5fm2A:
34.7		 5zv2A-5fm2A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 730
VAL A 738
ALA A 756
VAL A 804
TYR A 806
ALA A 807
GLY A 810
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.5A)
None
PP1  A2012 ( 3.5A)
PTR  A 809 (-2.4A)
 0.58A 5zv2A-5fm2A:
34.7		 5zv2A-5fm2A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 599
VAL A 607
ALA A 625
GLU A 644
MET A 648
TYR A 676
GLY A 680
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-4.0A)
748  A1001 ( 4.0A)
 0.64A 5zv2A-5grnA:
26.5		 5zv2A-5grnA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 PHE A 837
VAL A 607
ALA A 625
GLU A 644
MET A 648
TYR A 676
GLY A 680
 748  A1001 (-3.7A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-4.0A)
748  A1001 ( 4.0A)
 0.95A 5zv2A-5grnA:
26.5		 5zv2A-5grnA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		6 LEU A  20
VAL A  28
ALA A  41
GLU A  61
GLY A  96
ALA A 156
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
None
None
ADP  A 301 ( 4.8A)
 0.67A 5zv2A-5hu3A:
23.1		 5zv2A-5hu3A:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ak6 DESTRIN

(Homo sapiens;
Sus scrofa) 		PF00241
(Cofilin_ADF) 		3 LYS A 112
LEU A 108
ASP A  79
 None
 0.87A 5zv2A-1ak6A:
undetectable		 5zv2A-1ak6A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c0a ASPARTYL TRNA
SYNTHETASE

(Escherichia
coli) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		3 LYS A 283
LEU A 541
ASP A 224
 None
 0.81A 5zv2A-1c0aA:
undetectable		 5zv2A-1c0aA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT

(Escherichia
coli) 		PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		3 LYS A  76
LEU A 933
ASP A1057
 None
 0.53A 5zv2A-1c30A:
undetectable		 5zv2A-1c30A:
5.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzv GLUCOSE-6-PHOSPHATE
ISOMERASE

(Sus scrofa) 		PF00342
(PGI) 		3 LYS A 496
LEU A  52
ASP A 404
 None
 0.84A 5zv2A-1gzvA:
undetectable		 5zv2A-1gzvA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hjv CHITINASE-3 LIKE
PROTEIN 1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		3 LYS A 377
LEU A 354
ASP A  47
 None
 0.82A 5zv2A-1hjvA:
undetectable		 5zv2A-1hjvA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ihc GEPHYRIN

(Rattus
norvegicus) 		PF00994
(MoCF_biosynth) 		3 LYS A  57
LEU A  79
ASP A  72
 None
 0.94A 5zv2A-1ihcA:
undetectable		 5zv2A-1ihcA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jpu GLYCEROL
DEHYDROGENASE

(Geobacillus
stearothermophilus) 		PF00465
(Fe-ADH) 		3 LYS A 365
LEU A 283
ASP A 314
 None
 0.87A 5zv2A-1jpuA:
undetectable		 5zv2A-1jpuA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ktc ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Gallus gallus) 		PF16499
(Melibiase_2)
PF17450
(Melibiase_2_C) 		3 LYS A 303
LEU A 256
ASP A 214
 None
 0.68A 5zv2A-1ktcA:
undetectable		 5zv2A-1ktcA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ljy MGP-40

(Capra hircus) 		PF00704
(Glyco_hydro_18) 		3 LYS A 356
LEU A 333
ASP A  26
 None
 0.84A 5zv2A-1ljyA:
undetectable		 5zv2A-1ljyA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ltz PHENYLALANINE-4-HYDR
OXYLASE

(Chromobacterium
violaceum) 		PF00351
(Biopterin_H) 		3 LYS A  86
LEU A 140
ASP A  73
 None
 0.62A 5zv2A-1ltzA:
undetectable		 5zv2A-1ltzA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		3 LYS A 608
LEU A 731
ASP A 742
 None
 0.91A 5zv2A-1lufA:
33.0		 5zv2A-1lufA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ub0 PHOSPHOMETHYLPYRIMID
INE KINASE

(Thermus
thermophilus) 		PF08543
(Phos_pyr_kin) 		3 LYS A 173
LEU A 133
ASP A 103
 None
 0.95A 5zv2A-1ub0A:
undetectable		 5zv2A-1ub0A:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4u HEMOGLOBIN ALPHA
CHAIN

(Thunnus thynnus) 		PF00042
(Globin) 		3 LYS A  12
LEU A  78
ASP A  76
 None
 0.84A 5zv2A-1v4uA:
undetectable		 5zv2A-1v4uA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zrz PROTEIN KINASE C,
IOTA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		3 LYS A 274
LEU A 376
ASP A 387
 BI1  A1000 (-3.5A)
BI1  A1000 (-4.8A)
BI1  A1000 (-4.5A)
 0.93A 5zv2A-1zrzA:
12.1		 5zv2A-1zrzA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buj SERINE/THREONINE-PRO
TEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		3 LYS A  49
LEU A 155
ASP A 166
 STU  A1301 ( 4.0A)
STU  A1301 ( 4.8A)
None
 0.90A 5zv2A-2bujA:
22.7		 5zv2A-2bujA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1q LUCIFERIN
4-MONOOXYGENASE

(Luciola
cruciata) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 LYS A 374
LEU A 399
ASP A 415
 None
 0.90A 5zv2A-2d1qA:
undetectable		 5zv2A-2d1qA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dh3 4F2 CELL-SURFACE
ANTIGEN HEAVY CHAIN

(Homo sapiens) 		PF00128
(Alpha-amylase) 		3 LYS A 116
LEU A 298
ASP A 296
 None
 0.76A 5zv2A-2dh3A:
undetectable		 5zv2A-2dh3A:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e6m WERNER SYNDROME
ATP-DEPENDENT
HELICASE HOMOLOG

(Mus musculus) 		PF01612
(DNA_pol_A_exo1) 		3 LYS A 102
LEU A  67
ASP A  62
 None
 0.87A 5zv2A-2e6mA:
undetectable		 5zv2A-2e6mA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7y TRNASE Z

(Thermotoga
maritima) 		PF12706
(Lactamase_B_2) 		3 LYS A 259
LEU A 212
ASP A 226
 None
 0.92A 5zv2A-2e7yA:
undetectable		 5zv2A-2e7yA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2glf PROBABLE M18-FAMILY
AMINOPEPTIDASE 1

(Thermotoga
maritima) 		PF02127
(Peptidase_M18) 		3 LYS A 180
LEU A 186
ASP A 165
 None
 0.94A 5zv2A-2glfA:
undetectable		 5zv2A-2glfA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		3 LYS A 454
LEU A 553
ASP A 564
 4ST  A1687 (-3.4A)
4ST  A1687 (-4.4A)
4ST  A1687 (-4.7A)
 0.85A 5zv2A-2j0jA:
32.7		 5zv2A-2j0jA:
7.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6i HD DOMAIN PROTEIN

(Enterococcus
faecalis) 		PF01966
(HD) 		3 LYS A 327
LEU A 258
ASP A 318
 None
 0.95A 5zv2A-2o6iA:
undetectable		 5zv2A-2o6iA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oaj PROTEIN SNI1

(Saccharomyces
cerevisiae) 		PF08596
(Lgl_C) 		3 LYS A 754
LEU A 787
ASP A 843
 None
 0.76A 5zv2A-2oajA:
undetectable		 5zv2A-2oajA:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ptz ENOLASE

(Trypanosoma
brucei) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		3 LYS A 118
LEU A 110
ASP A 378
 None
 0.84A 5zv2A-2ptzA:
undetectable		 5zv2A-2ptzA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd5 DMPK PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		3 LYS A 100
LEU A 202
ASP A 213
 BI8  A1417 (-4.2A)
BI8  A1417 (-4.8A)
BI8  A1417 (-3.8A)
 0.94A 5zv2A-2vd5A:
19.6		 5zv2A-2vd5A:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnp FICOLIN-1

(Homo sapiens) 		PF00147
(Fibrinogen_C) 		3 LYS F 230
LEU F 262
ASP F 138
 None
 0.71A 5zv2A-2wnpF:
undetectable		 5zv2A-2wnpF:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xik SERINE/THREONINE
PROTEIN KINASE 25

(Homo sapiens) 		PF00069
(Pkinase) 		3 LYS A  49
LEU A 147
ASP A 158
 None
J60  A1294 (-4.8A)
J60  A1294 ( 4.6A)
 0.69A 5zv2A-2xikA:
18.8		 5zv2A-2xikA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsb HYALURONOGLUCOSAMINI
DASE

(Oceanicola
granulosus) 		PF07555
(NAGidase) 		3 LYS A  39
LEU A  82
ASP A 115
 GDL  A1436 ( 3.8A)
None
None
 0.83A 5zv2A-2xsbA:
undetectable		 5zv2A-2xsbA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsx BETA-ENOLASE

(Homo sapiens) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		3 LYS A 120
LEU A 112
ASP A 378
 None
None
EDO  A 511 (-4.3A)
 0.86A 5zv2A-2xsxA:
undetectable		 5zv2A-2xsxA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xt6 2-OXOGLUTARATE
DECARBOXYLASE

(Mycolicibacterium
smegmatis) 		PF00198
(2-oxoacid_dh)
PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		3 LYS A 894
LEU A 972
ASP A1004
 None
None
CA  A2003 (-2.5A)
 0.87A 5zv2A-2xt6A:
undetectable		 5zv2A-2xt6A:
5.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3a PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT BETA ISOFORM

(Mus musculus) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B) 		3 LYS A 776
LEU A 804
ASP A 931
 None
None
GD9  A2058 (-3.2A)
 0.89A 5zv2A-2y3aA:
2.4		 5zv2A-2y3aA:
5.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM

(Homo sapiens) 		PF00069
(Pkinase) 		3 LYS A  53
LEU A 160
ASP A 171
 None
B49  A1294 (-4.4A)
B49  A1294 (-4.2A)
 0.67A 5zv2A-2y7jA:
23.1		 5zv2A-2y7jA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z3b ATP-DEPENDENT
PROTEASE HSLV

(Bacillus
subtilis) 		PF00227
(Proteasome) 		3 LYS A  65
LEU A  97
ASP A  91
 None
 0.90A 5zv2A-2z3bA:
undetectable		 5zv2A-2z3bA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bj1 HEMOGLOBIN ALPHA

(Perca
flavescens) 		PF00042
(Globin) 		3 LYS A  11
LEU A  77
ASP A  75
 None
 0.91A 5zv2A-3bj1A:
undetectable		 5zv2A-3bj1A:
22.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 LYS A 514
LEU A 630
ASP A 641
 None
C4F  A   1 (-4.6A)
C4F  A   1 (-4.5A)
 0.72A 5zv2A-3c4fA:
43.9		 5zv2A-3c4fA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		3 LYS A1250
LEU A  77
ASP A 144
 ALF  A 501 ( 3.0A)
None
MG  A 500 (-2.9A)
 0.89A 5zv2A-3cmtA:
undetectable		 5zv2A-3cmtA:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		3 LYS A2250
LEU A1077
ASP A1144
 ALF  A1501 ( 2.7A)
None
MG  A1500 (-3.2A)
 0.88A 5zv2A-3cmtA:
undetectable		 5zv2A-3cmtA:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		3 LYS A3250
LEU A2077
ASP A2144
 ALF  A2501 ( 2.9A)
None
MG  A2500 (-3.2A)
 0.89A 5zv2A-3cmtA:
undetectable		 5zv2A-3cmtA:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		3 LYS A4250
LEU A3077
ASP A3144
 ALF  A3501 ( 2.8A)
None
MG  A3500 (-3.3A)
 0.88A 5zv2A-3cmtA:
undetectable		 5zv2A-3cmtA:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3du4 ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(Bacillus
subtilis) 		PF00202
(Aminotran_3) 		3 LYS A 133
LEU A 247
ASP A 245
 None
 0.85A 5zv2A-3du4A:
undetectable		 5zv2A-3du4A:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ge2 LIPOPROTEIN,
PUTATIVE

(Streptococcus
pneumoniae) 		PF12182
(DUF3642) 		3 LYS A 127
LEU A 151
ASP A  81
 GOL  A 203 ( 3.0A)
None
GOL  A 204 ( 4.2A)
 0.95A 5zv2A-3ge2A:
undetectable		 5zv2A-3ge2A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hko CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 2
CALMODULIN-LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		3 LYS A  39
LEU A 182
ASP A 195
 ANP  A 329 (-2.7A)
ANP  A 329 (-4.4A)
MG  A 330 ( 2.9A)
 0.62A 5zv2A-3hkoA:
20.8		 5zv2A-3hkoA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		3 LYS A  82
LEU A 182
ASP A 193
 None
 0.84A 5zv2A-3iecA:
22.3		 5zv2A-3iecA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3im9 MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Staphylococcus
aureus) 		PF00698
(Acyl_transf_1) 		3 LYS A  15
LEU A  33
ASP A  21
 None
 0.92A 5zv2A-3im9A:
undetectable		 5zv2A-3im9A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k8k ALPHA-AMYLASE, SUSG

(Bacteroides
thetaiotaomicron) 		PF00128
(Alpha-amylase) 		3 LYS A 659
LEU A 597
ASP A  52
 None
PEG  A 951 ( 4.0A)
None
 0.93A 5zv2A-3k8kA:
undetectable		 5zv2A-3k8kA:
7.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kcn ADENYLATE CYCLASE
HOMOLOG

(Rhodopirellula
baltica) 		PF00072
(Response_reg) 		3 LYS A 108
LEU A  22
ASP A  13
 None
 0.91A 5zv2A-3kcnA:
undetectable		 5zv2A-3kcnA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l8k DIHYDROLIPOYL
DEHYDROGENASE

(Sulfolobus
solfataricus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 LYS A 394
LEU A 209
ASP A 213
 None
 0.93A 5zv2A-3l8kA:
undetectable		 5zv2A-3l8kA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llt SERINE/THREONINE
KINASE-1, PFLAMMER

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		3 LYS A 581
LEU A 684
ASP A 720
 ANP  A 877 (-2.7A)
None
ANP  A 877 (-2.9A)
 0.95A 5zv2A-3lltA:
21.1		 5zv2A-3lltA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		3 LYS A  62
LEU A 165
ASP A 179
 QUE  A   1 (-4.1A)
None
QUE  A   1 (-2.9A)
 0.82A 5zv2A-3lm5A:
23.5		 5zv2A-3lm5A:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n9x PHOSPHOTRANSFERASE

(Plasmodium
berghei) 		PF00069
(Pkinase) 		3 LYS A  57
LEU A 161
ASP A 172
 GOL  A 433 (-3.2A)
GOL  A 434 (-4.2A)
GOL  A 433 (-2.7A)
 0.83A 5zv2A-3n9xA:
20.2		 5zv2A-3n9xA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n9x PHOSPHOTRANSFERASE

(Plasmodium
berghei) 		PF00069
(Pkinase) 		3 LYS A 211
LEU A 175
ASP A  68
 None
 0.76A 5zv2A-3n9xA:
20.2		 5zv2A-3n9xA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nku DRRA

(Legionella
pneumophila) 		no annotation 3 LYS A  43
LEU A 136
ASP A  79
 None
 0.57A 5zv2A-3nkuA:
undetectable		 5zv2A-3nkuA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8o 6-PHOSPHOFRUCTOKINAS
E SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00365
(PFK) 		3 LYS A 792
LEU A 838
ASP A 802
 None
 0.94A 5zv2A-3o8oA:
undetectable		 5zv2A-3o8oA:
7.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3obk DELTA-AMINOLEVULINIC
ACID DEHYDRATASE

(Toxoplasma
gondii) 		PF00490
(ALAD) 		3 LYS A 213
LEU A 208
ASP A 134
 PBG  A 360 (-2.8A)
None
PBG  A 360 (-3.8A)
 0.92A 5zv2A-3obkA:
undetectable		 5zv2A-3obkA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		3 LYS A  40
LEU A 141
ASP A 152
 None
 0.71A 5zv2A-3oz6A:
21.6		 5zv2A-3oz6A:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q60 ROP5B

(Toxoplasma
gondii) 		PF14531
(Kinase-like) 		3 LYS A 263
LEU A 304
ASP A 407
 MLI  A 601 ( 2.8A)
ATP  A 600 ( 4.8A)
MG  A 602 ( 2.5A)
 0.84A 5zv2A-3q60A:
18.9		 5zv2A-3q60A:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rjy ENDOGLUCANASE
FNCEL5A

(Fervidobacterium
nodosum) 		PF00150
(Cellulase) 		3 LYS A 343
LEU A 313
ASP A  79
 None
 0.68A 5zv2A-3rjyA:
undetectable		 5zv2A-3rjyA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s95 LIM DOMAIN KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 LYS A 368
LEU A 467
ASP A 478
 STU  A   1 (-3.1A)
STU  A   1 (-4.6A)
STU  A   1 ( 4.2A)
 0.76A 5zv2A-3s95A:
25.0		 5zv2A-3s95A:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sag EXOSOME COMPONENT 10

(Homo sapiens) 		PF00570
(HRDC)
PF01612
(DNA_pol_A_exo1) 		3 LYS A 480
LEU A 216
ASP A 252
 LYS  A 480 ( 0.0A)
LEU  A 216 ( 0.6A)
ASP  A 252 ( 0.6A)
 0.84A 5zv2A-3sagA:
undetectable		 5zv2A-3sagA:
12.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 LYS A 514
LEU A 630
ASP A 641
 07J  A   1 (-4.5A)
07J  A   1 ( 4.4A)
07J  A   1 (-4.7A)
 0.58A 5zv2A-3tt0A:
41.6		 5zv2A-3tt0A:
59.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 LYS A 868
LEU A1035
ASP A1046
 None
LEV  A1201 (-4.8A)
GOL  A1210 ( 3.4A)
 0.42A 5zv2A-3wzdA:
30.1		 5zv2A-3wzdA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 LYS A1980
LEU A2086
ASP A2102
 VGH  A3000 ( 4.7A)
VGH  A3000 (-4.3A)
None
 0.89A 5zv2A-3zbfA:
31.7		 5zv2A-3zbfA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhr MULTIFUNCTIONAL
2-OXOGLUTARATE
METABOLISM ENZYME

(Mycolicibacterium
smegmatis) 		PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		3 LYS A 894
LEU A 972
ASP A1004
 None
None
CA  A2003 (-2.1A)
 0.92A 5zv2A-3zhrA:
undetectable		 5zv2A-3zhrA:
7.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amq L544

(Acanthamoeba
polyphaga
mimivirus) 		no annotation 3 LYS A 182
LEU A 273
ASP A 276
 None
 0.69A 5zv2A-4amqA:
2.6		 5zv2A-4amqA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 LYS A 588
LEU A 699
ASP A 710
 None
LTI  A1839 (-4.2A)
None
 0.85A 5zv2A-4at3A:
32.0		 5zv2A-4at3A:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 LYS A 123
LEU A 223
ASP A 234
 30K  A1365 (-3.8A)
30K  A1365 (-4.5A)
30K  A1365 (-3.3A)
 0.81A 5zv2A-4aw5A:
27.9		 5zv2A-4aw5A:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bev COPPER EFFLUX ATPASE

(Legionella
pneumophila) 		PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase) 		3 LYS A 135
LEU A 199
ASP A  80
 None
 0.62A 5zv2A-4bevA:
undetectable		 5zv2A-4bevA:
7.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5

(Homo sapiens) 		PF00069
(Pkinase) 		3 LYS A  42
LEU A 142
ASP A 153
 38R  A1000 (-3.4A)
38R  A1000 ( 4.5A)
38R  A1000 ( 4.2A)
 0.80A 5zv2A-4bgqA:
17.1		 5zv2A-4bgqA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		3 LYS A 269
LEU A 371
ASP A 382
 None
 0.64A 5zv2A-4c0tA:
22.8		 5zv2A-4c0tA:
5.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c5f MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE C

(Escherichia
coli) 		PF01464
(SLT)
PF11873
(DUF3393) 		3 LYS A 348
LEU A 185
ASP A  81
 None
 0.79A 5zv2A-4c5fA:
undetectable		 5zv2A-4c5fA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cr2 26S PROTEASE
REGULATORY SUBUNIT 4
HOMOLOG

(Saccharomyces
cerevisiae) 		PF00004
(AAA) 		3 LYS I 214
LEU I 202
ASP I 321
 None
 0.85A 5zv2A-4cr2I:
undetectable		 5zv2A-4cr2I:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4esa HEMOGLOBIN ALPHA
CHAIN

(Eleginops
maclovinus) 		PF00042
(Globin) 		3 LYS A  11
LEU A  77
ASP A  75
 None
 0.91A 5zv2A-4esaA:
undetectable		 5zv2A-4esaA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g7f ENOLASE

(Trypanosoma
cruzi) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		3 LYS A 118
LEU A 110
ASP A 378
 None
 0.84A 5zv2A-4g7fA:
undetectable		 5zv2A-4g7fA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gew 5'-TYROSYL-DNA
PHOSPHODIESTERASE

(Caenorhabditis
elegans) 		PF03372
(Exo_endo_phos)
PF14555
(UBA_4) 		3 LYS A 181
LEU A 190
ASP A 168
 None
 0.83A 5zv2A-4gewA:
undetectable		 5zv2A-4gewA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hfs UNCHARACTERIZED
PROTEIN YNCM

(Bacillus
subtilis) 		PF15493
(YrpD) 		3 LYS A 189
LEU A 193
ASP A 230
 None
SO4  A 301 ( 4.9A)
None
 0.73A 5zv2A-4hfsA:
undetectable		 5zv2A-4hfsA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3b M1 FAMILY
AMINOPEPTIDASE

(Plasmodium
falciparum) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		3 LYS A 981
LEU A 933
ASP A 947
 None
 0.81A 5zv2A-4j3bA:
undetectable		 5zv2A-4j3bA:
6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kr5 GLUTAMINE ABC
TRANSPORTER PERMEASE
AND SUBSTRATE
BINDING PROTEIN
PROTEIN

(Lactococcus
lactis) 		PF00497
(SBP_bac_3) 		3 LYS A 368
LEU A 406
ASP A 356
 None
 0.87A 5zv2A-4kr5A:
undetectable		 5zv2A-4kr5A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6

(Homo sapiens) 		PF00069
(Pkinase) 		3 LYS A 436
LEU A 533
ASP A 544
 None
B49  A 701 (-4.5A)
B49  A 701 (-4.6A)
 0.80A 5zv2A-4ks8A:
23.0		 5zv2A-4ks8A:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lry PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK

(Escherichia
coli) 		PF02733
(Dak1) 		3 LYS A 179
LEU A 342
ASP A 336
 None
 0.89A 5zv2A-4lryA:
undetectable		 5zv2A-4lryA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		3 LYS B  53
LEU B 151
ASP B 162
 ADP  B 500 (-3.1A)
ADP  B 500 (-4.7A)
ADP  B 500 ( 3.4A)
 0.94A 5zv2A-4o27B:
20.1		 5zv2A-4o27B:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		3 LYS A 216
LEU A 321
ASP A 332
 None
ANW  A 601 (-4.9A)
None
 0.89A 5zv2A-4wboA:
22.1		 5zv2A-4wboA:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wmj GLUCOSE-6-PHOSPHATE
ISOMERASE

(Colias
eurytheme) 		PF00342
(PGI) 		3 LYS A 500
LEU A  57
ASP A 408
 None
 0.75A 5zv2A-4wmjA:
undetectable		 5zv2A-4wmjA:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x2m MTR2

(Chaetomium
thermophilum) 		no annotation 3 LYS A  38
LEU A 174
ASP A 160
 None
 0.86A 5zv2A-4x2mA:
undetectable		 5zv2A-4x2mA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbr PROTEIN
FAM212A,SERINE/THREO
NINE-PROTEIN KINASE
PAK 4

(Homo sapiens) 		PF00069
(Pkinase)
PF15342
(FAM212) 		3 LYS A 350
LEU A 447
ASP A 458
 ATP  A 601 (-2.8A)
None
ATP  A 601 ( 2.5A)
 0.84A 5zv2A-4xbrA:
17.9		 5zv2A-4xbrA:
16.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 LYS A 503
LEU A 619
ASP A 630
 40M  A1002 (-4.0A)
40M  A1002 (-4.5A)
40M  A1002 (-4.5A)
 0.60A 5zv2A-4xcuA:
38.4		 5zv2A-4xcuA:
65.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey9 LONG-CHAIN-FATTY-ACI
D--AMP LIGASE FADD32

(Mycobacterium
marinum) 		PF00501
(AMP-binding) 		3 LYS A 600
LEU A 226
ASP A 231
 5SV  A 701 (-2.6A)
None
5SV  A 701 (-2.9A)
 0.88A 5zv2A-5ey9A:
undetectable		 5zv2A-5ey9A:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax) 		PF00027
(cNMP_binding)
PF00069
(Pkinase) 		3 LYS A 563
LEU A 664
ASP A 675
 4ZS  A 901 (-3.9A)
4ZS  A 901 (-3.6A)
None
 0.84A 5zv2A-5ezrA:
18.3		 5zv2A-5ezrA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gxd AMP-DEPENDENT
SYNTHETASE AND
LIGASE

(Dinoroseobacter
shibae) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		3 LYS A 341
LEU A 363
ASP A 369
 None
 0.67A 5zv2A-5gxdA:
undetectable		 5zv2A-5gxdA:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 LYS A 745
LEU A 844
ASP A 855
 6HJ  A1101 (-4.2A)
6HJ  A1101 ( 4.8A)
6HJ  A1101 (-4.3A)
 0.69A 5zv2A-5j9zA:
31.2		 5zv2A-5j9zA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mov CASEIN KINASE II
SUBUNIT ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		3 LYS A  77
LEU A  85
ASP A 175
 None
None
HC4  A 401 (-4.0A)
 0.89A 5zv2A-5movA:
20.1		 5zv2A-5movA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oat SERINE/THREONINE-PRO
TEIN KINASE PINK1,
MITOCHONDRIAL-LIKE
PROTEIN

(Tribolium
castaneum) 		no annotation 3 LYS A 196
LEU A 344
ASP A 359
 None
None
MG  A 601 (-3.1A)
 0.80A 5zv2A-5oatA:
18.6		 5zv2A-5oatA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5okt CASEIN KINASE I
ISOFORM DELTA

(Homo sapiens) 		no annotation 3 LYS C  38
LEU C 135
ASP C 149
 9XK  C 301 ( 4.6A)
9XK  C 301 (-4.6A)
None
 0.85A 5zv2A-5oktC:
19.9		 5zv2A-5oktC:
29.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo sapiens) 		no annotation 3 LYS A  40
LEU A 139
ASP A 150
 7LV  A 401 (-3.0A)
7LV  A 401 (-4.9A)
7LV  A 401 (-4.2A)
 0.86A 5zv2A-5tvtA:
22.3		 5zv2A-5tvtA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		3 LYS A 170
LEU A  34
ASP A 534
 None
 0.91A 5zv2A-5uuuA:
21.3		 5zv2A-5uuuA:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7i PALMITOYLTRANSFERASE
ZDHHC17

(Homo sapiens) 		PF12796
(Ank_2) 		3 LYS A 266
LEU A 229
ASP A 252
 None
 0.90A 5zv2A-5w7iA:
undetectable		 5zv2A-5w7iA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wro ENOLASE

(Drosophila
melanogaster) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		3 LYS A 187
LEU A 179
ASP A 446
 None
 0.87A 5zv2A-5wroA:
undetectable		 5zv2A-5wroA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53

(Saccharomyces
cerevisiae) 		no annotation 3 LYS A 227
LEU A 326
ASP A 339
 None
 0.91A 5zv2A-5xzwA:
18.4		 5zv2A-5xzwA:
12.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4

(Homo sapiens) 		no annotation 3 LYS A 213
LEU A 318
ASP A 329
 CJT  A 502 (-3.0A)
CJT  A 502 (-4.7A)
CJT  A 502 ( 4.0A)
 0.73A 5zv2A-6f3dA:
23.1		 5zv2A-6f3dA:
34.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f79 -

(-) 		no annotation 3 LYS A 302
LEU A  99
ASP A  93
 None
 0.75A 5zv2A-6f79A:
undetectable		 5zv2A-6f79A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdy -

(-) 		no annotation 3 LYS U  44
LEU U 144
ASP U 157
 DB8  U 301 ( 4.0A)
DB8  U 301 (-4.8A)
DB8  U 301 (-3.6A)
 0.89A 5zv2A-6fdyU:
21.5		 5zv2A-6fdyU:
undetectable