SIMILAR PATTERNS OF AMINO ACIDS FOR 5ZSF_B_6T0B913

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ebn ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE F1

(Elizabethkingia
meningoseptica) 		PF00704
(Glyco_hydro_18) 		5 VAL A  58
PHE A 111
THR A 159
LEU A 155
ILE A  91
 None
 1.39A 5zsfA-2ebnA:
0.7
5zsfB-2ebnA:
0.0		 5zsfA-2ebnA:
15.02
5zsfB-2ebnA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Mus musculus) 		PF11921
(DUF3439)
PF13306
(LRR_5)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 TYR A 544
VAL A 514
PHE A 519
LEU A 549
ILE A 528
 None
 1.30A 5zsfA-2z81A:
16.6
5zsfB-2z81A:
17.5		 5zsfA-2z81A:
9.26
5zsfB-2z81A:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3djd FRUCTOSYL AMINE:
OXYGEN
OXIDOREDUCTASE

(Aspergillus
fumigatus) 		PF01266
(DAO) 		5 VAL A 424
PHE A 421
THR A 234
ILE A 334
THR A 237
 None
 1.08A 5zsfA-3djdA:
0.0
5zsfB-3djdA:
0.0		 5zsfA-3djdA:
9.79
5zsfB-3djdA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hri HISTIDYL-TRNA
SYNTHETASE

(Trypanosoma
brucei) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		5 VAL A 231
PHE A 228
LYS A 226
LEU A 255
ILE A 263
 None
 1.46A 5zsfA-3hriA:
0.0
5zsfB-3hriA:
0.0		 5zsfA-3hriA:
11.43
5zsfB-3hriA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mjg BETA-TYPE
PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF00047
(ig)
PF13927
(Ig_3) 		5 TYR X 249
VAL X 258
LEU X 233
ILE X 275
THR X 232
 None
 1.32A 5zsfA-3mjgX:
0.0
5zsfB-3mjgX:
0.0		 5zsfA-3mjgX:
15.41
5zsfB-3mjgX:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5c CYTOCHROME C551
PEROXIDASE

(Shewanella
oneidensis) 		PF00034
(Cytochrom_C)
PF03150
(CCP_MauG) 		5 TYR A 149
PHE A 145
THR A 160
ILE A 135
THR A 132
 None
 1.35A 5zsfA-3o5cA:
0.0
5zsfB-3o5cA:
undetectable		 5zsfA-3o5cA:
13.38
5zsfB-3o5cA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0m BETAINE ALDEHYDE
DEHYDROGENASE,
CHLOROPLASTIC

(Spinacia
oleracea) 		PF00171
(Aldedh) 		5 VAL A 197
PHE A 194
LEU A 162
ILE A 169
THR A 166
 None
 1.34A 5zsfA-4a0mA:
0.5
5zsfB-4a0mA:
0.0		 5zsfA-4a0mA:
11.85
5zsfB-4a0mA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jmj RNA/RNP
COMPLEX-1-INTERACTIN
G PHOSPHATASE

(Homo sapiens) 		PF00782
(DSPc) 		5 VAL A 107
PHE A 103
THR A  89
LEU A  66
THR A 132
 None
 1.50A 5zsfA-4jmjA:
undetectable
5zsfB-4jmjA:
0.0		 5zsfA-4jmjA:
22.50
5zsfB-4jmjA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b6k UNCHARACTERIZED
PROTEIN CGKR1

([Candida]
glabrata) 		PF01370
(Epimerase) 		5 TYR A 208
VAL A 207
PHE A 135
LEU A 314
ILE A 154
 None
 1.16A 5zsfA-5b6kA:
0.8
5zsfB-5b6kA:
1.7		 5zsfA-5b6kA:
13.64
5zsfB-5b6kA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e53 CONTACTIN-1

(Gallus gallus) 		PF00041
(fn3) 		5 VAL A 659
PHE A 670
THR A 634
ILE A 690
THR A 692
 None
 1.27A 5zsfA-5e53A:
undetectable
5zsfB-5e53A:
undetectable		 5zsfA-5e53A:
12.50
5zsfB-5e53A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e5b FACT COMPLEX SUBUNIT
SPT16

(Homo sapiens) 		PF00557
(Peptidase_M24)
PF14826
(FACT-Spt16_Nlob) 		5 VAL A 428
THR A 419
ASP A 405
LEU A 286
ILE A 403
 None
 1.26A 5zsfA-5e5bA:
undetectable
5zsfB-5e5bA:
undetectable		 5zsfA-5e5bA:
13.15
5zsfB-5e5bA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7l CONTACTIN-2

(Mus musculus) 		PF00041
(fn3) 		5 VAL A 674
PHE A 685
THR A 649
ILE A 705
THR A 707
 None
 1.27A 5zsfA-5e7lA:
undetectable
5zsfB-5e7lA:
undetectable		 5zsfA-5e7lA:
13.27
5zsfB-5e7lA:
13.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gmh TOLL-LIKE RECEPTOR 7

(Macaca mulatta) 		PF00560
(LRR_1)
PF13306
(LRR_5)
PF13855
(LRR_8) 		5 THR A 532
ASP A 555
LEU A 557
ILE A 585
THR A 586
 SO4  A 912 (-3.4A)
RX8  A 901 (-2.7A)
RX8  A 901 (-3.8A)
RX8  A 901 (-4.2A)
RX8  A 901 (-4.1A)
 0.20A 5zsfA-5gmhA:
61.2
5zsfB-5gmhA:
59.6		 5zsfA-5gmhA:
100.00
5zsfB-5gmhA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbd TUMOR PROTEIN P73

(Homo sapiens) 		PF00870
(P53) 		5 VAL A 238
THR A 158
LEU A 253
ILE A 161
THR A 251
 None
 1.42A 5zsfA-5kbdA:
undetectable
5zsfB-5kbdA:
undetectable		 5zsfA-5kbdA:
15.87
5zsfB-5kbdA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5szw ELAV-LIKE PROTEIN 1

(Homo sapiens) 		PF00076
(RRM_1) 		5 TYR A  70
VAL A  68
PHE A  42
THR A  82
ILE A  93
 None
 1.18A 5zsfA-5szwA:
undetectable
5zsfB-5szwA:
undetectable		 5zsfA-5szwA:
20.00
5zsfB-5szwA:
20.00