SIMILAR PATTERNS OF AMINO ACIDS FOR 5ZSF_A_6T0A910

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c1k BPT4 GENE 59
HELICASE ASSEMBLY
PROTEIN

(Escherichia
virus T4) 		PF08993
(T4_Gp59_N)
PF08994
(T4_Gp59_C) 		4 LEU A  24
ILE A  90
TYR A  50
PHE A  59
 None
 0.96A 5zsfA-1c1kA:
undetectable
5zsfB-1c1kA:
undetectable		 5zsfA-1c1kA:
13.62
5zsfB-1c1kA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE

(Pyrococcus
horikoshii) 		PF00291
(PALP) 		4 THR A 122
LEU A 100
ILE A  74
THR A  75
 None
 1.02A 5zsfA-1j0aA:
0.0
5zsfB-1j0aA:
0.0		 5zsfA-1j0aA:
13.85
5zsfB-1j0aA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ka0 HALOTOLERANCE
PROTEIN HAL2

(Saccharomyces
cerevisiae) 		PF00459
(Inositol_P) 		4 THR A 109
LEU A 115
ILE A  55
THR A  54
 None
 0.98A 5zsfA-1ka0A:
0.0
5zsfB-1ka0A:
0.0		 5zsfA-1ka0A:
10.76
5zsfB-1ka0A:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t9h PROBABLE GTPASE ENGC

(Bacillus
subtilis) 		PF03193
(RsgA_GTPase)
PF16745
(RsgA_N) 		4 ASP A  46
LEU A  43
ILE A  40
THR A  41
 None
 0.77A 5zsfA-1t9hA:
0.0
5zsfB-1t9hA:
0.0		 5zsfA-1t9hA:
12.79
5zsfB-1t9hA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1td0 HEAD DECORATION
PROTEIN

(Escherichia
virus Lambda) 		PF02924
(HDPD) 		4 THR A  82
ILE A  88
THR A  85
PHE A 103
 None
 0.99A 5zsfA-1td0A:
0.0
5zsfB-1td0A:
0.0		 5zsfA-1td0A:
17.59
5zsfB-1td0A:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdu TRAS1 ORF2P

(Bombyx mori) 		PF14529
(Exo_endo_phos_2) 		4 THR A 216
LEU A 152
ILE A 120
THR A 121
 None
 0.98A 5zsfA-1wduA:
0.0
5zsfB-1wduA:
0.0		 5zsfA-1wduA:
15.11
5zsfB-1wduA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wmr ISOPULLULANASE

(Aspergillus
niger) 		PF03718
(Glyco_hydro_49)
PF17433
(Glyco_hydro_49N) 		4 THR A 383
LEU A 411
ILE A 461
THR A 462
 None
NAG  A1006 (-3.6A)
None
NAG  A1006 ( 4.9A)
 1.03A 5zsfA-1wmrA:
1.5
5zsfB-1wmrA:
1.5		 5zsfA-1wmrA:
7.79
5zsfB-1wmrA:
7.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xv5 DNA
ALPHA-GLUCOSYLTRANSF
ERASE

(Escherichia
virus T4) 		PF11440
(AGT) 		4 THR A1317
LEU A1312
ILE A1345
TYR A1291
 None
 0.87A 5zsfA-1xv5A:
0.0
5zsfB-1xv5A:
0.0		 5zsfA-1xv5A:
11.25
5zsfB-1xv5A:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zq9 PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Homo sapiens) 		PF00398
(RrnaAD) 		4 THR A 230
LEU A 238
ILE A 276
PHE A 305
 None
 0.98A 5zsfA-1zq9A:
0.0
5zsfB-1zq9A:
1.2		 5zsfA-1zq9A:
15.70
5zsfB-1zq9A:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aeu HYPOTHETICAL PROTEIN
MJ0158

(Methanocaldococcus
jannaschii) 		PF03841
(SelA) 		4 LEU A 322
ILE A 329
THR A 330
TYR A 359
 None
 0.85A 5zsfA-2aeuA:
0.0
5zsfB-2aeuA:
0.0		 5zsfA-2aeuA:
13.94
5zsfB-2aeuA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4g DIHYDROOROTATE
DEHYDROGENASE

(Trypanosoma
brucei) 		PF01180
(DHO_dh) 		4 THR A 123
LEU A  97
ILE A  42
TYR A  83
 None
 0.99A 5zsfA-2b4gA:
undetectable
5zsfB-2b4gA:
undetectable		 5zsfA-2b4gA:
15.30
5zsfB-2b4gA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bpa PROTEIN (SUBUNIT OF
BACTERIOPHAGE
PHIX174)

(Escherichia
virus phiX174) 		PF02305
(Phage_F) 		4 THR 1  68
ILE 1  30
THR 1  29
PHE 1 408
 None
 0.97A 5zsfA-2bpa1:
undetectable
5zsfB-2bpa1:
undetectable		 5zsfA-2bpa1:
10.02
5zsfB-2bpa1:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c7z 3-KETOACYL-COA
THIOLASE 2

(Arabidopsis
thaliana) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 ASP A 261
LEU A  62
ILE A 238
THR A  60
 None
 0.79A 5zsfA-2c7zA:
undetectable
5zsfB-2c7zA:
undetectable		 5zsfA-2c7zA:
11.14
5zsfB-2c7zA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cev PROTEIN (ARGINASE)

([Bacillus]
caldovelox) 		PF00491
(Arginase) 		4 THR A 218
LEU A 214
ILE A 211
THR A 210
 None
 0.90A 5zsfA-2cevA:
undetectable
5zsfB-2cevA:
undetectable		 5zsfA-2cevA:
13.54
5zsfB-2cevA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1c ISOCITRATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00180
(Iso_dh) 		4 THR A  80
ILE A  74
THR A  73
PHE A 107
 None
 0.95A 5zsfA-2d1cA:
undetectable
5zsfB-2d1cA:
undetectable		 5zsfA-2d1cA:
10.83
5zsfB-2d1cA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d2r UNDECAPRENYL
PYROPHOSPHATE
SYNTHASE

(Helicobacter
pylori) 		PF01255
(Prenyltransf) 		4 THR A 118
LEU A 114
ILE A 111
THR A 110
 None
 1.03A 5zsfA-2d2rA:
undetectable
5zsfB-2d2rA:
undetectable		 5zsfA-2d2rA:
14.16
5zsfB-2d2rA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2de0 ALPHA-(1,6)-FUCOSYLT
RANSFERASE

(Homo sapiens) 		PF14604
(SH3_9) 		4 THR X 408
ASP X 410
LEU X 413
TYR X 382
 None
 1.01A 5zsfA-2de0X:
undetectable
5zsfB-2de0X:
undetectable		 5zsfA-2de0X:
9.63
5zsfB-2de0X:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gca FOLYLPOLYGLUTAMATE
SYNTHASE

(Lactobacillus
casei) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 THR A  45
LEU A 163
ILE A 267
THR A 197
 None
 1.04A 5zsfA-2gcaA:
undetectable
5zsfB-2gcaA:
undetectable		 5zsfA-2gcaA:
11.57
5zsfB-2gcaA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gj2 WSV230

(White spot
syndrome virus) 		PF09625
(VP9) 		4 THR A  66
ASP A  68
LEU A  71
TYR A  43
 None
 0.97A 5zsfA-2gj2A:
undetectable
5zsfB-2gj2A:
undetectable		 5zsfA-2gj2A:
18.60
5zsfB-2gj2A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gvh AGR_L_2016P

(Agrobacterium
fabrum) 		PF03061
(4HBT) 		4 THR A 228
LEU A 230
ILE A 242
THR A 243
 None
 1.03A 5zsfA-2gvhA:
undetectable
5zsfB-2gvhA:
undetectable		 5zsfA-2gvhA:
14.76
5zsfB-2gvhA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ltf TAIL PROTEIN X

(Escherichia
virus P2) 		PF05489
(Phage_tail_X) 		4 THR A  47
LEU A  43
ILE A  14
THR A  10
 None
 0.95A 5zsfA-2ltfA:
undetectable
5zsfB-2ltfA:
undetectable		 5zsfA-2ltfA:
21.79
5zsfB-2ltfA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vhd CYTOCHROME C551
PEROXIDASE

(Pseudomonas
aeruginosa) 		PF00034
(Cytochrom_C)
PF03150
(CCP_MauG) 		4 THR A 125
LEU A 121
ILE A 109
THR A 118
 None
 0.85A 5zsfA-2vhdA:
undetectable
5zsfB-2vhdA:
undetectable		 5zsfA-2vhdA:
13.43
5zsfB-2vhdA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsw 72 KDA INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		4 THR A 392
LEU A 407
ILE A 421
THR A 422
 None
 1.03A 5zsfA-2xswA:
undetectable
5zsfB-2xswA:
undetectable		 5zsfA-2xswA:
11.05
5zsfB-2xswA:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3m PROTEIN TRANSPORT
PROTEIN HOFQ

(Aggregatibacter
actinomycetemcomitans) 		PF03958
(Secretin_N) 		4 THR A 132
LEU A 171
ILE A 161
THR A 162
 None
 0.97A 5zsfA-2y3mA:
undetectable
5zsfB-2y3mA:
undetectable		 5zsfA-2y3mA:
20.13
5zsfB-2y3mA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zcn BIOFILM OPERON
ICAABCD HTH-TYPE
NEGATIVE
TRANSCRIPTIONAL
REGULATOR ICAR

(Staphylococcus
epidermidis) 		PF00440
(TetR_N) 		4 THR A  21
LEU A  12
ILE A  10
THR A  11
 None
 1.02A 5zsfA-2zcnA:
undetectable
5zsfB-2zcnA:
undetectable		 5zsfA-2zcnA:
17.49
5zsfB-2zcnA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aov PUTATIVE
UNCHARACTERIZED
PROTEIN PH0207

(Pyrococcus
horikoshii) 		PF00155
(Aminotran_1_2) 		4 LEU A 141
ILE A 136
TYR A 168
PHE A 161
 None
 1.03A 5zsfA-3aovA:
0.5
5zsfB-3aovA:
undetectable		 5zsfA-3aovA:
10.22
5zsfB-3aovA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bc8 O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE

(Mus musculus) 		PF05889
(SepSecS) 		4 LEU A 114
ILE A 117
THR A 118
PHE A  54
 None
 0.93A 5zsfA-3bc8A:
undetectable
5zsfB-3bc8A:
undetectable		 5zsfA-3bc8A:
10.59
5zsfB-3bc8A:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bkh LYTIC
TRANSGLYCOSYLASE

(Pseudomonas
virus phiKZ) 		PF01464
(SLT)
PF01471
(PG_binding_1) 		4 THR A 221
LEU A 218
ILE A 244
THR A 243
 None
 0.93A 5zsfA-3bkhA:
undetectable
5zsfB-3bkhA:
undetectable		 5zsfA-3bkhA:
13.26
5zsfB-3bkhA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c9f 5'-NUCLEOTIDASE

(Candida
albicans) 		PF00149
(Metallophos) 		4 THR A  35
ILE A 101
THR A  99
TYR A 107
 None
 0.96A 5zsfA-3c9fA:
2.3
5zsfB-3c9fA:
undetectable		 5zsfA-3c9fA:
8.87
5zsfB-3c9fA:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3djd FRUCTOSYL AMINE:
OXYGEN
OXIDOREDUCTASE

(Aspergillus
fumigatus) 		PF01266
(DAO) 		4 THR A 234
ILE A 334
THR A 237
PHE A 421
 None
 1.02A 5zsfA-3djdA:
undetectable
5zsfB-3djdA:
undetectable		 5zsfA-3djdA:
9.79
5zsfB-3djdA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3etn PUTATIVE
PHOSPHOSUGAR
ISOMERASE INVOLVED
IN CAPSULE FORMATION

(Bacteroides
fragilis) 		PF01380
(SIS) 		4 THR A  45
LEU A  92
ILE A  32
PHE A  62
 None
 0.96A 5zsfA-3etnA:
undetectable
5zsfB-3etnA:
undetectable		 5zsfA-3etnA:
14.03
5zsfB-3etnA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gg4 GLYCEROL KINASE

(Yersinia
pseudotuberculosis) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 LEU A 264
ILE A 261
THR A 260
TYR A 315
 None
 1.03A 5zsfA-3gg4A:
undetectable
5zsfB-3gg4A:
undetectable		 5zsfA-3gg4A:
9.64
5zsfB-3gg4A:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7n NUCLEOPORIN NUP120

(Saccharomyces
cerevisiae) 		PF11715
(Nup160) 		4 THR A  77
LEU A  78
ILE A  95
THR A  80
 None
 1.03A 5zsfA-3h7nA:
undetectable
5zsfB-3h7nA:
undetectable		 5zsfA-3h7nA:
7.63
5zsfB-3h7nA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i0z PUTATIVE
TAGATOSE-6-PHOSPHATE
KETOSE/ALDOSE
ISOMERASE

(Streptococcus
pneumoniae) 		PF01380
(SIS) 		4 THR A 110
LEU A 112
ILE A  91
THR A  61
 None
 1.01A 5zsfA-3i0zA:
undetectable
5zsfB-3i0zA:
undetectable		 5zsfA-3i0zA:
13.06
5zsfB-3i0zA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9d OUTER CAPSID PROTEIN
VP2

(Bluetongue
virus) 		PF00898
(Orbi_VP2) 		4 LEU A  80
ILE A  78
THR A  79
TYR A 861
 None
 0.99A 5zsfA-3j9dA:
undetectable
5zsfB-3j9dA:
undetectable		 5zsfA-3j9dA:
6.46
5zsfB-3j9dA:
6.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m07 PUTATIVE ALPHA
AMYLASE

(Salmonella
enterica) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		4 THR A 333
LEU A 407
ILE A 405
THR A 406
 None
None
CL  A 601 (-4.0A)
None
 1.00A 5zsfA-3m07A:
0.6
5zsfB-3m07A:
0.4		 5zsfA-3m07A:
9.46
5zsfB-3m07A:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mv3 COATOMER SUBUNIT
ALPHA

(Saccharomyces
cerevisiae) 		PF06957
(COPI_C) 		4 THR A1169
ASP A1166
LEU A1168
TYR A1018
 None
 1.04A 5zsfA-3mv3A:
undetectable
5zsfB-3mv3A:
undetectable		 5zsfA-3mv3A:
13.88
5zsfB-3mv3A:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3net HISTIDYL-TRNA
SYNTHETASE

(Nostoc sp. PCC
7120) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		4 THR A  32
LEU A  29
ILE A 346
PHE A 169
 None
 0.73A 5zsfA-3netA:
undetectable
5zsfB-3netA:
undetectable		 5zsfA-3netA:
8.60
5zsfB-3netA:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3noq THIJ/PFPI FAMILY
PROTEIN

(Pseudomonas
fluorescens) 		PF01965
(DJ-1_PfpI) 		4 THR A  19
LEU A  16
ILE A 156
THR A 153
 None
 1.01A 5zsfA-3noqA:
undetectable
5zsfB-3noqA:
undetectable		 5zsfA-3noqA:
16.59
5zsfB-3noqA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvs 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Vibrio cholerae) 		PF00275
(EPSP_synthase) 		4 LEU A 206
ILE A 204
THR A 205
TYR A 221
 None
 1.00A 5zsfA-3nvsA:
undetectable
5zsfB-3nvsA:
undetectable		 5zsfA-3nvsA:
10.25
5zsfB-3nvsA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5c CYTOCHROME C551
PEROXIDASE

(Shewanella
oneidensis) 		PF00034
(Cytochrom_C)
PF03150
(CCP_MauG) 		5 THR A 160
ILE A 135
THR A 132
TYR A 149
PHE A 145
 None
 1.33A 5zsfA-3o5cA:
undetectable
5zsfB-3o5cA:
undetectable		 5zsfA-3o5cA:
13.38
5zsfB-3o5cA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC

(Homo sapiens) 		PF00856
(SET) 		4 THR A 178
ILE A 156
THR A 149
TYR A 207
 None
 1.02A 5zsfA-3ooiA:
undetectable
5zsfB-3ooiA:
undetectable		 5zsfA-3ooiA:
17.41
5zsfB-3ooiA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 THR A 274
ILE A  72
THR A  68
PHE A 332
 None
None
SO4  A1203 (-3.2A)
None
 1.03A 5zsfA-3pdsA:
undetectable
5zsfB-3pdsA:
undetectable		 5zsfA-3pdsA:
10.81
5zsfB-3pdsA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Francisella
tularensis) 		PF00342
(PGI) 		4 THR A  89
ILE A  69
TYR A 496
PHE A 485
 None
 0.93A 5zsfA-3q88A:
undetectable
5zsfB-3q88A:
undetectable		 5zsfA-3q88A:
9.59
5zsfB-3q88A:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ro2 G-PROTEIN-SIGNALING
MODULATOR 2
PEPTIDE OF NUCLEAR
MITOTIC APPARATUS
PROTEIN 1

(Mus musculus;
Homo sapiens) 		PF13176
(TPR_7)
PF13424
(TPR_12)
no annotation 		4 THR A 286
ILE A 246
TYR A 279
PHE B1992
 None
 0.95A 5zsfA-3ro2A:
undetectable
5zsfB-3ro2A:
undetectable		 5zsfA-3ro2A:
12.46
5zsfB-3ro2A:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s47 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Clostridium
beijerinckii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 THR A 400
ILE A 393
THR A 397
PHE A 213
 None
 0.95A 5zsfA-3s47A:
undetectable
5zsfB-3s47A:
undetectable		 5zsfA-3s47A:
11.22
5zsfB-3s47A:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ti2 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Vibrio cholerae) 		PF00275
(EPSP_synthase) 		4 LEU A 206
ILE A 204
THR A 205
TYR A 221
 None
 0.91A 5zsfA-3ti2A:
undetectable
5zsfB-3ti2A:
undetectable		 5zsfA-3ti2A:
15.45
5zsfB-3ti2A:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vn3 ANTIFREEZE PROTEIN

(Typhula
ishikariensis) 		PF11999
(DUF3494) 		4 THR A 113
LEU A 110
ILE A 158
TYR A 120
 EDO  A 304 ( 4.7A)
None
None
None
 0.81A 5zsfA-3vn3A:
1.4
5zsfB-3vn3A:
1.3		 5zsfA-3vn3A:
15.42
5zsfB-3vn3A:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vu9 CHROMOSOME
SEGREGATION IN
MEIOSIS PROTEIN 2

(Saccharomyces
cerevisiae) 		PF16834
(CSM2) 		4 LEU B 162
ILE B   9
THR B  10
TYR B   3
 None
None
EDO  B 301 ( 4.1A)
None
 0.93A 5zsfA-3vu9B:
undetectable
5zsfB-3vu9B:
undetectable		 5zsfA-3vu9B:
17.65
5zsfB-3vu9B:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vuu ERYTHROCYTE MEMBRANE
PROTEIN, PUTATIVE

(Plasmodium
falciparum) 		PF05424
(Duffy_binding) 		4 THR A 222
ILE A 215
THR A 216
PHE A 233
 None
 0.98A 5zsfA-3vuuA:
undetectable
5zsfB-3vuuA:
undetectable		 5zsfA-3vuuA:
12.67
5zsfB-3vuuA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vuv ERYTHROCYTE MEMBRANE
PROTEIN, PUTATIVE

(Plasmodium
falciparum) 		PF05424
(Duffy_binding) 		4 THR A 222
ILE A 215
THR A 216
PHE A 233
 None
 1.02A 5zsfA-3vuvA:
undetectable
5zsfB-3vuvA:
undetectable		 5zsfA-3vuvA:
13.47
5zsfB-3vuvA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wob HYPOTHETICAL PROTEIN

(Sus scrofa) 		PF01419
(Jacalin) 		4 ILE A 142
THR A 143
TYR A  28
PHE A  29
 None
 1.03A 5zsfA-3wobA:
undetectable
5zsfB-3wobA:
undetectable		 5zsfA-3wobA:
17.99
5zsfB-3wobA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wqf D-THREO-3-HYDROXYASP
ARTATE DEHYDRATASE

(Delftia sp.
HT23) 		PF01168
(Ala_racemase_N)
PF14031
(D-ser_dehydrat) 		4 THR A  44
ILE A  62
THR A  63
TYR A 238
 None
 0.98A 5zsfA-3wqfA:
undetectable
5zsfB-3wqfA:
undetectable		 5zsfA-3wqfA:
12.26
5zsfB-3wqfA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES

(Mycolicibacterium
smegmatis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 THR A 345
ASP A 342
LEU A 344
TYR A 234
 None
CL  A1587 ( 4.4A)
None
None
 0.98A 5zsfA-3zo9A:
undetectable
5zsfB-3zo9A:
undetectable		 5zsfA-3zo9A:
8.58
5zsfB-3zo9A:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zpp CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
pneumoniae) 		PF12708
(Pectate_lyase_3)
PF13229
(Beta_helix) 		4 THR A 355
LEU A 304
ILE A 281
THR A 280
 None
 0.94A 5zsfA-3zppA:
4.0
5zsfB-3zppA:
4.5		 5zsfA-3zppA:
9.26
5zsfB-3zppA:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b62 TSSL1

(Pseudomonas
aeruginosa) 		PF00691
(OmpA) 		4 THR A 414
LEU A 370
ILE A 441
THR A 442
 None
None
None
EDO  A1447 (-2.9A)
 0.98A 5zsfA-4b62A:
undetectable
5zsfB-4b62A:
undetectable		 5zsfA-4b62A:
17.20
5zsfB-4b62A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxs VENOM PROTHROMBIN
ACTIVATOR
PSEUTARIN-C
NON-CATALYTIC
SUBUNIT

(Pseudonaja
textilis) 		PF00754
(F5_F8_type_C)
PF07732
(Cu-oxidase_3) 		4 THR V 463
ASP V 464
LEU V 461
THR V 459
 None
 0.78A 5zsfA-4bxsV:
undetectable
5zsfB-4bxsV:
undetectable		 5zsfA-4bxsV:
4.77
5zsfB-4bxsV:
4.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dkj CYTOSINE-SPECIFIC
METHYLTRANSFERASE

(Mycoplasma
penetrans) 		PF00145
(DNA_methylase) 		4 THR A 387
ILE A 236
TYR A 215
PHE A 248
 None
 0.92A 5zsfA-4dkjA:
undetectable
5zsfB-4dkjA:
undetectable		 5zsfA-4dkjA:
10.92
5zsfB-4dkjA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fix UDP-GALACTOFURANOSYL
TRANSFERASE GLFT2

(Mycobacterium
tuberculosis) 		PF13641
(Glyco_tranf_2_3) 		4 THR A 141
ILE A 137
THR A 138
PHE A 108
 None
 0.92A 5zsfA-4fixA:
undetectable
5zsfB-4fixA:
undetectable		 5zsfA-4fixA:
9.17
5zsfB-4fixA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gbr BETA-2 ADRENERGIC
RECEPTOR

(Homo sapiens) 		PF00001
(7tm_1) 		4 THR A 246
ILE A  72
THR A  68
PHE A 304
 None
 0.95A 5zsfA-4gbrA:
undetectable
5zsfB-4gbrA:
undetectable		 5zsfA-4gbrA:
14.23
5zsfB-4gbrA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jp0 43.8 KDA
INSECTICIDAL CRYSTAL
PROTEIN

(Bacillus
thuringiensis) 		PF05431
(Toxin_10) 		4 THR A 246
LEU A 247
THR A 268
TYR A 203
 None
 0.99A 5zsfA-4jp0A:
undetectable
5zsfB-4jp0A:
undetectable		 5zsfA-4jp0A:
9.97
5zsfB-4jp0A:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mob ACYL-COENZYME A
THIOESTERASE 12

(Homo sapiens) 		PF03061
(4HBT) 		4 THR A 130
ASP A 133
LEU A 129
THR A 127
 None
 0.96A 5zsfA-4mobA:
undetectable
5zsfB-4mobA:
undetectable		 5zsfA-4mobA:
13.41
5zsfB-4mobA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mr0 PLASMIN AND
FIBRONECTIN-BINDING
PROTEIN A

(Streptococcus
pneumoniae) 		PF12708
(Pectate_lyase_3)
PF13229
(Beta_helix) 		4 THR A 366
LEU A 315
ILE A 292
THR A 291
 BME  A 701 (-4.4A)
BME  A 701 ( 4.3A)
None
None
 0.90A 5zsfA-4mr0A:
2.8
5zsfB-4mr0A:
3.5		 5zsfA-4mr0A:
7.15
5zsfB-4mr0A:
7.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfu EDS1

(Arabidopsis
thaliana) 		PF01764
(Lipase_3) 		4 THR A 236
LEU A 194
ILE A 192
THR A 193
 None
 0.95A 5zsfA-4nfuA:
undetectable
5zsfB-4nfuA:
undetectable		 5zsfA-4nfuA:
8.56
5zsfB-4nfuA:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ru4 TAIL SPIKE PROTEIN
GP49

(Pseudomonas
virus LKA1) 		PF13229
(Beta_helix) 		4 LEU A 545
THR A 584
TYR A 332
PHE A 328
 None
 0.94A 5zsfA-4ru4A:
2.4
5zsfB-4ru4A:
3.9		 5zsfA-4ru4A:
9.35
5zsfB-4ru4A:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uj6 SURFACE LAYER
PROTEIN

(Geobacillus
stearothermophilus) 		PF13205
(Big_5) 		4 THR A 336
LEU A 339
ILE A 289
THR A 287
 None
 0.98A 5zsfA-4uj6A:
undetectable
5zsfB-4uj6A:
undetectable		 5zsfA-4uj6A:
8.01
5zsfB-4uj6A:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wct FRUCTOSYL
AMINE:OXYGEN
OXIDOREDUCTASE

(Aspergillus
fumigatus) 		PF01266
(DAO) 		4 THR A 239
ILE A 341
THR A 242
PHE A 428
 None
 1.01A 5zsfA-4wctA:
undetectable
5zsfB-4wctA:
undetectable		 5zsfA-4wctA:
9.98
5zsfB-4wctA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wfq SUPPRESSOR OF
STEM-LOOP PROTEIN 1

(Saccharomyces
cerevisiae) 		PF04056
(Ssl1) 		4 THR A 280
LEU A 254
ILE A 247
THR A 250
 None
 0.96A 5zsfA-4wfqA:
undetectable
5zsfB-4wfqA:
undetectable		 5zsfA-4wfqA:
16.32
5zsfB-4wfqA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wv4 TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 10
TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 8

(Homo sapiens;
Homo sapiens) 		PF03540
(TFIID_30kDa)
PF07524
(Bromo_TP) 		4 THR B  96
ILE A 151
THR B  89
PHE A 144
 None
None
GOL  A 301 (-3.6A)
None
 0.88A 5zsfA-4wv4B:
undetectable
5zsfB-4wv4B:
undetectable		 5zsfA-4wv4B:
23.71
5zsfB-4wv4B:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7g IPT/TIG
DOMAIN-CONTAINING
PROTEIN BACOVA_02650

(Bacteroides
ovatus) 		no annotation 4 THR A 154
ILE A 138
THR A 139
PHE A 160
 None
 0.86A 5zsfA-5e7gA:
undetectable
5zsfB-5e7gA:
undetectable		 5zsfA-5e7gA:
12.31
5zsfB-5e7gA:
12.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gmh TOLL-LIKE RECEPTOR 7

(Macaca mulatta) 		PF00560
(LRR_1)
PF13306
(LRR_5)
PF13855
(LRR_8) 		5 THR A 532
ASP A 555
LEU A 557
ILE A 585
THR A 586
 SO4  A 912 (-3.4A)
RX8  A 901 (-2.7A)
RX8  A 901 (-3.8A)
RX8  A 901 (-4.2A)
RX8  A 901 (-4.1A)
 0.25A 5zsfA-5gmhA:
21.1
5zsfB-5gmhA:
27.9		 5zsfA-5gmhA:
100.00
5zsfB-5gmhA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gvv GLYCOSYL TRANSFERASE
FAMILY 8

(Streptococcus
pneumoniae) 		PF01501
(Glyco_transf_8) 		4 ASP A 108
LEU A 109
ILE A 229
TYR A 104
 MN  A 501 ( 1.8A)
None
UDP  A 502 (-4.3A)
None
 0.98A 5zsfA-5gvvA:
undetectable
5zsfB-5gvvA:
undetectable		 5zsfA-5gvvA:
12.21
5zsfB-5gvvA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum) 		PF11894
(Nup192) 		4 THR B 958
ILE B1038
THR B1037
PHE B1024
 None
 0.83A 5zsfA-5hb4B:
undetectable
5zsfB-5hb4B:
undetectable		 5zsfA-5hb4B:
4.05
5zsfB-5hb4B:
4.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdm GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
1, CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00202
(Aminotran_3) 		4 THR A 236
LEU A 232
ILE A 265
PHE A 245
 None
 1.02A 5zsfA-5hdmA:
undetectable
5zsfB-5hdmA:
undetectable		 5zsfA-5hdmA:
10.37
5zsfB-5hdmA:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ilt BOVINE FAB A01 HEAVY
CHAIN

(Bos taurus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU H 142
ILE H 110
THR H 119
TYR H 147
 None
 0.99A 5zsfA-5iltH:
undetectable
5zsfB-5iltH:
undetectable		 5zsfA-5iltH:
16.29
5zsfB-5iltH:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6e FK506-BINDING
PROTEIN 1A

(Aspergillus
fumigatus) 		PF00254
(FKBP_C) 		4 LEU A  31
ILE A  99
THR A  32
TYR A  83
 None
 1.00A 5zsfA-5j6eA:
undetectable
5zsfB-5j6eA:
undetectable		 5zsfA-5j6eA:
23.93
5zsfB-5j6eA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jcv LMO2181 PROTEIN

(Listeria
monocytogenes) 		PF04203
(Sortase) 		4 ILE A 221
THR A 222
TYR A 147
PHE A 159
 None
 0.94A 5zsfA-5jcvA:
undetectable
5zsfB-5jcvA:
undetectable		 5zsfA-5jcvA:
17.88
5zsfB-5jcvA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jir OOP FAMILY OMPA-OMPF
PORIN

(Treponema
pallidum) 		no annotation 4 THR B 444
LEU B 404
ILE B 471
THR B 472
 None
 0.94A 5zsfA-5jirB:
undetectable
5zsfB-5jirB:
undetectable		 5zsfA-5jirB:
13.62
5zsfB-5jirB:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jou ALPHA-XYLOSIDASE
BOGH31A

(Bacteroides
ovatus) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110) 		4 THR A 109
LEU A 106
ILE A  94
THR A  93
 None
 0.99A 5zsfA-5jouA:
undetectable
5zsfB-5jouA:
0.0		 5zsfA-5jouA:
6.08
5zsfB-5jouA:
6.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2

(Homo sapiens) 		PF00856
(SET) 		4 THR A1150
ILE A1128
THR A1121
TYR A1179
 None
None
None
SAM  A1304 (-4.1A)
 1.03A 5zsfA-5lsuA:
undetectable
5zsfB-5lsuA:
undetectable		 5zsfA-5lsuA:
14.68
5zsfB-5lsuA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lub LEGUMAIN

(Homo sapiens) 		no annotation 4 LEU B 117
ILE B 170
THR B 169
PHE B 184
 None
 0.96A 5zsfA-5lubB:
undetectable
5zsfB-5lubB:
undetectable		 5zsfA-5lubB:
14.40
5zsfB-5lubB:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mjs TUBULIN BETA CHAIN

(Schizosaccharomyces
pombe) 		no annotation 4 THR A 311
LEU A 310
ILE A 373
THR A 371
 None
 1.02A 5zsfA-5mjsA:
undetectable
5zsfB-5mjsA:
undetectable		 5zsfA-5mjsA:
12.20
5zsfB-5mjsA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o9e PUTATIVE U3 SMALL
NUCLEOLAR
RIBONUCLEOPROTEIN

(Chaetomium
thermophilum) 		PF04427
(Brix) 		4 THR A  91
LEU A 141
ILE A 152
THR A 153
 None
 0.94A 5zsfA-5o9eA:
undetectable
5zsfB-5o9eA:
undetectable		 5zsfA-5o9eA:
19.54
5zsfB-5o9eA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oqj SUPPRESSOR OF
STEM-LOOP PROTEIN 1

(Saccharomyces
cerevisiae) 		no annotation 4 THR 6 280
LEU 6 254
ILE 6 247
THR 6 250
 None
 0.97A 5zsfA-5oqj6:
undetectable
5zsfB-5oqj6:
undetectable		 5zsfA-5oqj6:
16.30
5zsfB-5oqj6:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tbf TRANSLATION
ELONGATION FACTOR

(Vibrio cholerae) 		PF11826
(DUF3346) 		4 THR A 258
LEU A 347
ILE A 323
THR A 322
 None
 1.00A 5zsfA-5tbfA:
undetectable
5zsfB-5tbfA:
undetectable		 5zsfA-5tbfA:
12.62
5zsfB-5tbfA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v4s TRANSPORTER, CATION
CHANNEL FAMILY /
CYCLIC
NUCLEOTIDE-BINDING
DOMAIN MULTI-DOMAIN
PROTEIN

(Leptospira
licerasiae) 		PF00027
(cNMP_binding)
PF00520
(Ion_trans) 		4 THR A 193
ILE A 202
THR A 203
TYR A 212
 None
 0.96A 5zsfA-5v4sA:
undetectable
5zsfB-5v4sA:
undetectable		 5zsfA-5v4sA:
10.00
5zsfB-5v4sA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vbb RNA PSEUDOURIDYLATE
SYNTHASE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00849
(PseudoU_synth_2) 		4 THR A 170
LEU A 145
ILE A 114
THR A 113
 SO4  A 302 ( 4.0A)
None
None
None
 0.88A 5zsfA-5vbbA:
undetectable
5zsfB-5vbbA:
undetectable		 5zsfA-5vbbA:
14.47
5zsfB-5vbbA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vev PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Neisseria
gonorrhoeae) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 LEU A 272
ILE A 283
THR A 282
PHE A 289
 None
 1.00A 5zsfA-5vevA:
undetectable
5zsfB-5vevA:
undetectable		 5zsfA-5vevA:
11.73
5zsfB-5vevA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyw PYRUVATE CARBOXYLASE

(Lactococcus
lactis) 		PF00289
(Biotin_carb_N)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 THR A 464
LEU A 468
ILE A 471
THR A 472
 None
 0.92A 5zsfA-5vywA:
undetectable
5zsfB-5vywA:
undetectable		 5zsfA-5vywA:
5.85
5zsfB-5vywA:
5.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		4 THR B 312
LEU B 311
ILE B 374
THR B 372
 None
 0.90A 5zsfA-5w3jB:
undetectable
5zsfB-5w3jB:
undetectable		 5zsfA-5w3jB:
13.29
5zsfB-5w3jB:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtc NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5, MITOCHONDRIAL
NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
5
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2

(Homo sapiens;
Homo sapiens;
Homo sapiens) 		no annotation
no annotation
no annotation 		4 THR i  89
ILE a 174
THR a 173
TYR h  60
 None
 0.82A 5zsfA-5xtci:
undetectable
5zsfB-5xtci:
undetectable		 5zsfA-5xtci:
11.80
5zsfB-5xtci:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtd NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1

(Homo sapiens) 		PF15879
(MWFE) 		4 THR s  67
LEU s  70
ILE s  72
THR s  73
 None
 1.00A 5zsfA-5xtds:
undetectable
5zsfB-5xtds:
undetectable		 5zsfA-5xtds:
12.32
5zsfB-5xtds:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwb 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Colwellia
psychrerythraea) 		PF00275
(EPSP_synthase) 		4 LEU A 206
ILE A 204
THR A 205
TYR A 221
 None
 0.89A 5zsfA-5xwbA:
undetectable
5zsfB-5xwbA:
undetectable		 5zsfA-5xwbA:
11.93
5zsfB-5xwbA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cjq -

(-) 		no annotation 4 THR A 180
ILE A 189
THR A 190
TYR A 199
 None
 1.00A 5zsfA-6cjqA:
undetectable
5zsfB-6cjqA:
undetectable		 5zsfA-6cjqA:
undetectable
5zsfB-6cjqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmz DIHYDROLIPOYL
DEHYDROGENASE

(Burkholderia
cenocepacia) 		no annotation 4 THR A 350
LEU A 188
ILE A 186
TYR A 214
 None
None
FAD  A 502 (-4.0A)
None
 0.87A 5zsfA-6cmzA:
undetectable
5zsfB-6cmzA:
undetectable		 5zsfA-6cmzA:
27.91
5zsfB-6cmzA:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cr0 (S)-6-HYDROXYNICOTIN
E OXIDASE

(Shinella sp.
HZN7) 		no annotation 4 THR A 168
LEU A 169
ILE A 334
THR A 333
 None
MPD  A 505 ( 4.5A)
None
MPD  A 505 ( 4.5A)
 1.03A 5zsfA-6cr0A:
undetectable
5zsfB-6cr0A:
undetectable		 5zsfA-6cr0A:
16.67
5zsfB-6cr0A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dft -

(-) 		no annotation 4 THR A 104
LEU A 101
ILE A 110
PHE A 436
 None
NAD  A 502 (-4.6A)
None
None
 1.00A 5zsfA-6dftA:
1.4
5zsfB-6dftA:
undetectable		 5zsfA-6dftA:
undetectable
5zsfB-6dftA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoj PROTEIN CFT1

(Saccharomyces
cerevisiae) 		no annotation 4 LEU A 253
ILE A 271
THR A 270
TYR A 250
 None
 1.00A 5zsfA-6eojA:
undetectable
5zsfB-6eojA:
undetectable		 5zsfA-6eojA:
4.83
5zsfB-6eojA:
4.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ey5 T9SS COMPONENT
CYTOPLASMIC MEMBRANE
PROTEIN PORM

(Porphyromonas
gingivalis) 		no annotation 4 THR A 244
ASP A 243
ILE A 388
THR A 387
 None
 0.99A 5zsfA-6ey5A:
undetectable
5zsfB-6ey5A:
undetectable		 5zsfA-6ey5A:
22.22
5zsfB-6ey5A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gne -

(-) 		no annotation 4 ASP A  45
ILE A 420
THR A 417
TYR A 390
 ADP  A 601 (-3.4A)
None
ADP  A 601 (-3.7A)
ADP  A 601 (-3.7A)
 1.00A 5zsfA-6gneA:
undetectable
5zsfB-6gneA:
undetectable		 5zsfA-6gneA:
undetectable
5zsfB-6gneA:
undetectable