SIMILAR PATTERNS OF AMINO ACIDS FOR 5ZRF_F_EVPF1301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k82 FORMAMIDOPYRIMIDINE-
DNA GLYCOSYLASE

(Escherichia
coli) 		PF01149
(Fapy_DNA_glyco)
PF06827
(zf-FPG_IleRS)
PF06831
(H2TH) 		4 GLY A  75
ASP A 106
ARG A 108
MET A 158
 None
 1.45A 5zrfA-1k82A:
0.0		 5zrfA-1k82A:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
METHANOL
DEHYDROGENASE
SUBUNIT 2

(Paracoccus
denitrificans) 		PF01011
(PQQ)
PF02315
(MDH)
PF13360
(PQQ_2) 		4 GLY A 131
ASP A 130
ARG A 126
MET B  58
 None
 1.15A 5zrfA-1lrwA:
0.0		 5zrfA-1lrwA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sde D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Streptomyces
sp. R61) 		PF00144
(Beta-lactamase) 		4 GLY A  49
ASP A  45
ARG A  46
MET A 335
 None
 1.39A 5zrfA-1sdeA:
undetectable		 5zrfA-1sdeA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1u CHOLINE
O-ACETYLTRANSFERASE

(Rattus
norvegicus) 		PF00755
(Carn_acyltransf) 		4 GLY A 323
ASP A 325
ARG A 295
MET A 354
 None
 1.34A 5zrfA-1t1uA:
1.9		 5zrfA-1t1uA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1c CARBOXYPEPTIDASE B

(Helicoverpa zea) 		PF00246
(Peptidase_M14) 		4 GLY A 305
ASP A 306
ARG A 302
MET A 195
 None
 0.83A 5zrfA-2c1cA:
0.0		 5zrfA-2c1cA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gz6 N-ACETYL-D-GLUCOSAMI
NE 2-EPIMERASE

(Anabaena sp.
CH1) 		PF07221
(GlcNAc_2-epim) 		4 GLY A  43
ASP A  40
ARG A  41
MET A 377
 None
 1.24A 5zrfA-2gz6A:
0.0		 5zrfA-2gz6A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ovl PUTATIVE RACEMASE

(Streptomyces
coelicolor) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLY A 278
ASP A 108
ARG A 283
MET A 333
 None
 0.93A 5zrfA-2ovlA:
0.6		 5zrfA-2ovlA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0r CALPAIN-9

(Homo sapiens) 		PF00648
(Peptidase_C2) 		4 GLY A 315
ASP A 314
ARG A 275
MET A 196
 None
CA  A1002 (-3.0A)
None
None
 1.28A 5zrfA-2p0rA:
undetectable		 5zrfA-2p0rA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3els PRE-MRNA LEAKAGE
PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00498
(FHA) 		4 GLY A 183
ASP A 184
ARG A 181
MET A  65
 None
 1.08A 5zrfA-3elsA:
0.0		 5zrfA-3elsA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]

(Escherichia
coli) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 GLY A 249
ASP A 247
ARG A 343
MET A 430
 None
None
PO4  A 616 (-3.7A)
None
 1.43A 5zrfA-3eyaA:
undetectable		 5zrfA-3eyaA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2o F-BOX ONLY PROTEIN 4

(Homo sapiens) 		PF00646
(F-box) 		4 GLY B 288
ASP B 287
ARG B 178
MET B 198
 None
 1.26A 5zrfA-3l2oB:
2.4		 5zrfA-3l2oB:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l82 F-BOX ONLY PROTEIN 4

(Homo sapiens) 		no annotation 4 GLY B 288
ASP B 287
ARG B 178
MET B 198
 None
 1.28A 5zrfA-3l82B:
undetectable		 5zrfA-3l82B:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lij CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 GLY A 420
ASP A 423
ARG A 426
MET A 508
 None
CA  A 518 (-3.1A)
None
None
 1.23A 5zrfA-3lijA:
undetectable		 5zrfA-3lijA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3npe 9-CIS-EPOXYCAROTENOI
D DIOXYGENASE 1,
CHLOROPLASTIC

(Zea mays) 		PF03055
(RPE65) 		4 GLY A 244
ASP A 266
ARG A 199
MET A 370
 None
 1.50A 5zrfA-3npeA:
undetectable		 5zrfA-3npeA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3or2 SULFITE REDCUTASE
SUBUNIT ALPHA

(Desulfovibrio
gigas) 		PF01077
(NIR_SIR) 		4 GLY A 320
ASP A 242
ARG A 305
MET A 193
 None
 1.30A 5zrfA-3or2A:
2.9		 5zrfA-3or2A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdk PHOSPHOGLUCOSAMINE
MUTASE

(Bacillus
anthracis) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 GLY A 243
ASP A 242
ARG A 245
MET A 315
 None
 1.14A 5zrfA-3pdkA:
undetectable		 5zrfA-3pdkA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsz RICIN B LECTIN

(Ruminiclostridium
thermocellum) 		PF04616
(Glyco_hydro_43)
PF14200
(RicinB_lectin_2) 		4 GLY A  61
ASP A  62
ARG A  84
MET A 300
 None
 1.45A 5zrfA-3vszA:
undetectable		 5zrfA-3vszA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f9d POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE

(Escherichia
coli) 		PF01522
(Polysacc_deac_1)
PF14883
(GHL13) 		4 GLY A 461
ASP A 460
ARG A 529
MET A 377
 None
 1.32A 5zrfA-4f9dA:
undetectable		 5zrfA-4f9dA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h4a MITOCHONDRIAL
CARDIOLIPIN
HYDROLASE

(Drosophila
melanogaster) 		PF13091
(PLDc_2) 		4 GLY A 177
ASP A 176
ARG A 180
MET A 168
 None
 1.36A 5zrfA-4h4aA:
undetectable		 5zrfA-4h4aA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica) 		PF13458
(Peripla_BP_6) 		4 GLY A 239
ASP A 242
ARG A 228
MET A 178
 None
 1.08A 5zrfA-4kv7A:
1.9		 5zrfA-4kv7A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lim DNA PRIMASE SMALL
SUBUNIT

(Saccharomyces
cerevisiae) 		PF01896
(DNA_primase_S) 		4 GLY A 166
ASP A 113
ARG A 164
MET A  15
 None
 1.32A 5zrfA-4limA:
1.8		 5zrfA-4limA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p7l POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE

(Escherichia
coli) 		PF14883
(GHL13) 		4 GLY A 461
ASP A 460
ARG A 529
MET A 377
 None
 1.49A 5zrfA-4p7lA:
undetectable		 5zrfA-4p7lA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9a TAT PATHWAY SIGNAL
SEQUENCE DOMAIN
PROTEIN

(Parabacteroides
merdae) 		PF13472
(Lipase_GDSL_2) 		4 GLY A 181
ASP A 180
ARG A 179
MET A 248
 None
 1.08A 5zrfA-4q9aA:
3.0		 5zrfA-4q9aA:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfu GLYCOSIDE HYDROLASE
FAMILY 5

(Bacteroides
vulgatus) 		PF12904
(Collagen_bind_2)
PF13204
(DUF4038) 		4 GLY A 434
ASP A 433
ARG A 306
MET A 412
 None
 1.48A 5zrfA-4qfuA:
undetectable		 5zrfA-4qfuA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xcv NADP-DEPENDENT
2-HYDROXYACID
DEHYDROGENASE

(Rhizobium etli) 		PF02826
(2-Hacid_dh_C) 		4 GLY A 222
ASP A 221
ARG A 220
MET A 145
 None
 1.24A 5zrfA-4xcvA:
1.8		 5zrfA-4xcvA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA

(Methylobacillus
flagellatus) 		PF00364
(Biotin_lipoyl)
PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		4 GLY C 374
ASP C 121
ARG C 398
MET C 429
 None
 1.27A 5zrfA-5ks8C:
undetectable		 5zrfA-5ks8C:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l8s AMINO ACYL PEPTIDASE

(Sporosarcina
psychrophila) 		PF00326
(Peptidase_S9) 		4 GLY A 571
ASP A 540
ARG A 542
MET A 388
 None
 1.39A 5zrfA-5l8sA:
1.2		 5zrfA-5l8sA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b2v SORB

(Sorangium
cellulosum) 		no annotation 4 GLY A 260
ASP A 244
ARG A 230
MET A 142
 None
 1.36A 5zrfA-6b2vA:
undetectable		 5zrfA-6b2vA:
7.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bdt CALPAIN-3

(Homo sapiens) 		no annotation 4 GLY A 395
ASP A 394
ARG A 355
MET A 228
 None
CA  A 502 (-3.3A)
None
None
 1.29A 5zrfA-6bdtA:
undetectable		 5zrfA-6bdtA:
6.94