SIMILAR PATTERNS OF AMINO ACIDS FOR 5ZRF_D_EVPD101_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1au8 CATHEPSIN G

(Homo sapiens) 		PF00089
(Trypsin) 		4 GLY A 140
ASP A 194
ARG A 156
GLN A  74
 None
 1.36A 5zrfB-1au8A:
undetectable		 5zrfB-1au8A:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4o MALTODEXTRIN
PHOSPHORYLASE

(Escherichia
coli) 		PF00343
(Phosphorylase) 		4 ASP A 356
ARG A 354
GLN A 272
MET A  66
 None
 1.35A 5zrfB-1e4oA:
1.6		 5zrfB-1e4oA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h0h FORMATE
DEHYDROGENASE
SUBUNIT ALPHA

(Desulfovibrio
gigas) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 GLY A 414
ASP A 417
ARG A 407
GLN A 590
 None
 1.34A 5zrfB-1h0hA:
1.4		 5zrfB-1h0hA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h0h FORMATE
DEHYDROGENASE
SUBUNIT ALPHA

(Desulfovibrio
gigas) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 GLY A 414
ASP A 417
ARG A 587
GLN A 590
 None
 1.48A 5zrfB-1h0hA:
1.4		 5zrfB-1h0hA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k82 FORMAMIDOPYRIMIDINE-
DNA GLYCOSYLASE

(Escherichia
coli) 		PF01149
(Fapy_DNA_glyco)
PF06827
(zf-FPG_IleRS)
PF06831
(H2TH) 		4 GLY A  75
ASP A 106
ARG A 108
MET A 158
 None
 1.45A 5zrfB-1k82A:
undetectable		 5zrfB-1k82A:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kqf FORMATE
DEHYDROGENASE,
NITRATE-INDUCIBLE,
MAJOR SUBUNIT

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 GLY A 453
ASP A 456
ARG A 446
GLN A 634
 None
 1.36A 5zrfB-1kqfA:
undetectable		 5zrfB-1kqfA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kv9 TYPE II
QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE

(Pseudomonas
putida) 		PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3) 		4 GLY A 334
ASP A 330
ARG A 331
GLN A 319
 None
 1.35A 5zrfB-1kv9A:
undetectable		 5zrfB-1kv9A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1
METHANOL
DEHYDROGENASE
SUBUNIT 2

(Paracoccus
denitrificans) 		PF01011
(PQQ)
PF02315
(MDH)
PF13360
(PQQ_2) 		4 GLY A 131
ASP A 130
ARG A 126
MET B  58
 None
 1.12A 5zrfB-1lrwA:
undetectable		 5zrfB-1lrwA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqq ALPHA-D-GLUCURONIDAS
E

(Geobacillus
stearothermophilus) 		PF03648
(Glyco_hydro_67N)
PF07477
(Glyco_hydro_67C)
PF07488
(Glyco_hydro_67M) 		4 GLY A 447
ASP A 449
ARG A 164
GLN A 396
 None
 1.36A 5zrfB-1mqqA:
undetectable		 5zrfB-1mqqA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 GLY B 712
ASP B 794
ARG B 716
GLN B 790
 None
 1.32A 5zrfB-1n60B:
undetectable		 5zrfB-1n60B:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nyq THREONYL-TRNA
SYNTHETASE 1

(Staphylococcus
aureus) 		PF00587
(tRNA-synt_2b)
PF02824
(TGS)
PF03129
(HGTP_anticodon)
PF07973
(tRNA_SAD) 		4 GLY A 380
ARG A 379
GLN A 376
MET A 480
 None
 1.40A 5zrfB-1nyqA:
undetectable		 5zrfB-1nyqA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o8c YHDH

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A 220
ASP A 221
ARG A 198
GLN A 230
 None
None
NDP  A1325 (-3.6A)
None
 1.25A 5zrfB-1o8cA:
undetectable		 5zrfB-1o8cA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ph5 TELOMERE-BINDING
PROTEIN ALPHA
SUBUNIT

(Sterkiella nova) 		PF02765
(POT1) 		4 GLY A 117
ASP A 118
ARG A 193
GLN A 301
 None
 1.45A 5zrfB-1ph5A:
undetectable		 5zrfB-1ph5A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pxy FIMBRIN-LIKE PROTEIN

(Arabidopsis
thaliana) 		PF00307
(CH) 		4 GLY A 138
ASP A 139
ARG A 135
GLN A 239
 None
 1.27A 5zrfB-1pxyA:
undetectable		 5zrfB-1pxyA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rrc POLYNUCLEOTIDE
KINASE

(Escherichia
virus T4) 		PF13671
(AAA_33) 		4 GLY A 168
ASP A 278
ARG A 279
GLN A 245
 CA  A 700 ( 4.6A)
CA  A 700 (-3.1A)
None
None
 1.31A 5zrfB-1rrcA:
undetectable		 5zrfB-1rrcA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sde D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Streptomyces
sp. R61) 		PF00144
(Beta-lactamase) 		4 GLY A  49
ASP A  45
ARG A  46
MET A 335
 None
 1.39A 5zrfB-1sdeA:
undetectable		 5zrfB-1sdeA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1u CHOLINE
O-ACETYLTRANSFERASE

(Rattus
norvegicus) 		PF00755
(Carn_acyltransf) 		4 GLY A 323
ASP A 325
ARG A 295
MET A 354
 None
 1.37A 5zrfB-1t1uA:
undetectable		 5zrfB-1t1uA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlu GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE

(Saccharomyces
cerevisiae) 		PF00171
(Aldedh) 		4 GLY A 116
ASP A 200
ARG A  12
GLN A 422
 None
 1.19A 5zrfB-1vluA:
undetectable		 5zrfB-1vluA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE

(Pseudomonas
putida) 		PF01011
(PQQ)
PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3) 		4 GLY A 339
ASP A 335
ARG A 336
GLN A 324
 None
 1.47A 5zrfB-1yiqA:
undetectable		 5zrfB-1yiqA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yvp 60-KDA SS-A/RO
RIBONUCLEOPROTEIN

(Xenopus laevis) 		PF05731
(TROVE) 		4 GLY A 525
ASP A 523
ARG A  34
GLN A  82
 None
 1.31A 5zrfB-1yvpA:
2.1		 5zrfB-1yvpA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bpa PROTEIN (SUBUNIT OF
BACTERIOPHAGE
PHIX174)

(Escherichia
virus phiX174) 		PF02305
(Phage_F) 		4 GLY 1 159
ASP 1 155
ARG 1 161
GLN 1 401
 None
 1.28A 5zrfB-2bpa1:
undetectable		 5zrfB-2bpa1:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1c CARBOXYPEPTIDASE B

(Helicoverpa zea) 		PF00246
(Peptidase_M14) 		4 GLY A 305
ASP A 306
ARG A 302
MET A 195
 None
 0.90A 5zrfB-2c1cA:
3.2		 5zrfB-2c1cA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c9k PESTICIDAL CRYSTAL
PROTEIN CRY4AA

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 GLY A 558
ASP A 565
ARG A 328
GLN A 540
 None
 0.99A 5zrfB-2c9kA:
undetectable		 5zrfB-2c9kA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1y HYPOTHETICAL PROTEIN
TT0321

(Thermus
thermophilus) 		PF13561
(adh_short_C2) 		4 GLY A  13
ASP A  37
ARG A  16
GLN A  24
 NAD  A1001 (-3.5A)
NAD  A1001 (-2.8A)
NAD  A1001 (-3.8A)
None
 1.15A 5zrfB-2d1yA:
2.4		 5zrfB-2d1yA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7z ACETYLENE HYDRATASE
AHY

(Pelobacter
acetylenicus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		4 GLY A 219
ASP A 221
ARG A 720
GLN A 714
 MGD  A 802 (-3.5A)
MGD  A 802 (-2.7A)
MGD  A 802 (-2.5A)
None
 1.31A 5zrfB-2e7zA:
2.2		 5zrfB-2e7zA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2glf PROBABLE M18-FAMILY
AMINOPEPTIDASE 1

(Thermotoga
maritima) 		PF02127
(Peptidase_M18) 		4 ASP A 310
ARG A 300
GLN A 306
MET A  64
 None
 1.46A 5zrfB-2glfA:
2.8		 5zrfB-2glfA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gv9 DNA POLYMERASE

(Human
alphaherpesvirus
1) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 GLY A 489
ARG A 492
GLN A  63
MET A 162
 None
 1.27A 5zrfB-2gv9A:
2.3		 5zrfB-2gv9A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iv2 FORMATE
DEHYDROGENASE H

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 GLY X 340
ASP X 343
ARG X 460
GLN X 463
 None
 1.35A 5zrfB-2iv2X:
undetectable		 5zrfB-2iv2X:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0r CALPAIN-9

(Homo sapiens) 		PF00648
(Peptidase_C2) 		4 GLY A 315
ASP A 314
ARG A 275
MET A 196
 None
CA  A1002 (-3.0A)
None
None
 1.34A 5zrfB-2p0rA:
undetectable		 5zrfB-2p0rA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pla GLYCEROL-3-PHOSPHATE
DEHYDROGENASE 1-LIKE
PROTEIN

(Homo sapiens) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		4 GLY A 214
ASP A 217
ARG A 281
GLN A 338
 None
 1.30A 5zrfB-2plaA:
undetectable		 5zrfB-2plaA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wfx HEDGEHOG-INTERACTING
PROTEIN

(Homo sapiens) 		PF07995
(GSDH) 		4 GLY B 390
ASP B 371
ARG B 464
GLN B 356
 None
 1.27A 5zrfB-2wfxB:
undetectable		 5zrfB-2wfxB:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3auv SC-DSFV DERIVED FROM
THE G6-FAB

(Homo sapiens) 		PF07686
(V-set) 		4 GLY A  79
ASP A  39
ARG A  35
GLN A 100
 None
 1.43A 5zrfB-3auvA:
undetectable		 5zrfB-3auvA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bg9 PYRUVATE
CARBOXYLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		4 GLY A 689
ARG A 644
GLN A 640
MET A 566
 None
 1.32A 5zrfB-3bg9A:
undetectable		 5zrfB-3bg9A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d9w PUTATIVE
ACETYLTRANSFERASE

(Nocardia
farcinica) 		PF00797
(Acetyltransf_2) 		4 GLY A 159
ASP A 160
GLN A 181
MET A 109
 None
 1.23A 5zrfB-3d9wA:
undetectable		 5zrfB-3d9wA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efv PUTATIVE
SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE

(Salmonella
enterica) 		PF00171
(Aldedh) 		4 GLY A 237
ASP A 239
GLN A 266
MET A  79
 None
 1.36A 5zrfB-3efvA:
undetectable		 5zrfB-3efvA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3els PRE-MRNA LEAKAGE
PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00498
(FHA) 		4 GLY A 183
ASP A 184
ARG A 181
MET A  65
 None
 1.11A 5zrfB-3elsA:
undetectable		 5zrfB-3elsA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]

(Escherichia
coli) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 GLY A 249
ASP A 247
ARG A 343
MET A 430
 None
None
PO4  A 616 (-3.7A)
None
 1.42A 5zrfB-3eyaA:
2.4		 5zrfB-3eyaA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gqj CELL INHIBITING
FACTOR (CIF)

(Photorhabdus
laumondii) 		PF16374
(CIF) 		4 GLY A 180
ASP A 176
ARG A 177
GLN A 128
 None
 1.34A 5zrfB-3gqjA:
undetectable		 5zrfB-3gqjA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ieh PUTATIVE
METALLOPEPTIDASE

(Shewanella
baltica) 		PF04952
(AstE_AspA) 		4 GLY A 164
ASP A 163
ARG A 162
GLN A  57
 None
 1.31A 5zrfB-3iehA:
undetectable		 5zrfB-3iehA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j08 COPPER-EXPORTING
P-TYPE ATPASE A

(Archaeoglobus
fulgidus) 		PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase) 		4 GLY A 736
ASP A 737
ARG A 734
GLN A 663
 None
 1.06A 5zrfB-3j08A:
undetectable		 5zrfB-3j08A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jcu OXYGEN-EVOLVING
ENHANCER PROTEIN 2,
CHLOROPLASTIC

(Spinacia
oleracea) 		PF01789
(PsbP) 		4 GLY P 138
ASP P 137
ARG P 134
GLN P  91
 None
 1.24A 5zrfB-3jcuP:
undetectable		 5zrfB-3jcuP:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jd5 28S RIBOSOMAL
PROTEIN S34,
MITOCHONDRIAL

(Bos taurus) 		PF00338
(Ribosomal_S10) 		4 GLY j 112
ASP j 103
ARG j 101
GLN j 207
 None
None
U  A 881 ( 3.1A)
None
 1.49A 5zrfB-3jd5j:
undetectable		 5zrfB-3jd5j:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kxd CALCIUM-GATED
POTASSIUM CHANNEL
MTHK

(Methanothermobacter
thermautotrophicus) 		PF02080
(TrkA_C)
PF02254
(TrkA_N) 		4 GLY A 246
ASP A 245
ARG A 241
MET A 264
 None
 1.47A 5zrfB-3kxdA:
undetectable		 5zrfB-3kxdA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2o F-BOX ONLY PROTEIN 4

(Homo sapiens) 		PF00646
(F-box) 		4 GLY B 288
ASP B 287
ARG B 178
MET B 198
 None
 1.29A 5zrfB-3l2oB:
2.9		 5zrfB-3l2oB:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l82 F-BOX ONLY PROTEIN 4

(Homo sapiens) 		no annotation 4 GLY B 288
ASP B 287
ARG B 178
MET B 198
 None
 1.33A 5zrfB-3l82B:
2.2		 5zrfB-3l82B:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lij CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 GLY A 420
ASP A 423
ARG A 426
MET A 508
 None
CA  A 518 (-3.1A)
None
None
 1.29A 5zrfB-3lijA:
undetectable		 5zrfB-3lijA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m4p ASPARAGINYL-TRNA
SYNTHETASE, PUTATIVE

(Entamoeba
histolytica) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 GLY A  54
ASP A  51
ARG A  50
GLN A  57
 None
 1.50A 5zrfB-3m4pA:
undetectable		 5zrfB-3m4pA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdq EXOPOLYPHOSPHATASE

(Cytophaga
hutchinsonii) 		PF02541
(Ppx-GppA) 		4 GLY A  87
ARG A  85
GLN A 163
MET A 271
 None
None
None
SO4  A 318 (-4.6A)
 1.44A 5zrfB-3mdqA:
undetectable		 5zrfB-3mdqA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3npe 9-CIS-EPOXYCAROTENOI
D DIOXYGENASE 1,
CHLOROPLASTIC

(Zea mays) 		PF03055
(RPE65) 		4 GLY A 244
ASP A 266
ARG A 199
MET A 370
 None
 1.46A 5zrfB-3npeA:
undetectable		 5zrfB-3npeA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nx4 PUTATIVE
OXIDOREDUCTASE

(Salmonella
enterica) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A 220
ASP A 221
ARG A 198
GLN A 230
 None
None
NAP  A 330 (-3.6A)
None
 1.26A 5zrfB-3nx4A:
undetectable		 5zrfB-3nx4A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3om5 LEVANSUCRASE

(Bacillus
megaterium) 		PF02435
(Glyco_hydro_68) 		4 GLY A 294
ASP A  49
ARG A  48
GLN A 301
 None
 1.29A 5zrfB-3om5A:
undetectable		 5zrfB-3om5A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3or2 SULFITE REDCUTASE
SUBUNIT ALPHA

(Desulfovibrio
gigas) 		PF01077
(NIR_SIR) 		4 GLY A 320
ASP A 242
ARG A 305
MET A 193
 None
 1.28A 5zrfB-3or2A:
2.8		 5zrfB-3or2A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdk PHOSPHOGLUCOSAMINE
MUTASE

(Bacillus
anthracis) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 GLY A 243
ASP A 242
ARG A 245
MET A 315
 None
 1.13A 5zrfB-3pdkA:
undetectable		 5zrfB-3pdkA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9o EXOTOXIN A

(Vibrio cholerae) 		PF09009
(Exotox-A_cataly)
PF09101
(Exotox-A_bind)
PF09102
(Exotox-A_target) 		4 GLY A 279
ASP A 297
ARG A 419
GLN A 356
 None
None
None
NAD  A 700 (-3.6A)
 1.26A 5zrfB-3q9oA:
undetectable		 5zrfB-3q9oA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ros NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Lactobacillus
acidophilus) 		PF00171
(Aldedh) 		4 GLY A 232
ASP A 234
GLN A 261
MET A  74
 None
 1.45A 5zrfB-3rosA:
undetectable		 5zrfB-3rosA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tdu DCN1-LIKE PROTEIN 1

(Homo sapiens) 		PF03556
(Cullin_binding) 		4 GLY A  85
ASP A  84
GLN A 114
MET A 177
 None
 1.43A 5zrfB-3tduA:
undetectable		 5zrfB-3tduA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vc1 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E

(Streptomyces
coelicolor) 		PF08241
(Methyltransf_11) 		4 GLY A  41
ASP A  42
ARG A 139
GLN A 132
 None
None
None
SAH  A 302 (-3.1A)
 1.43A 5zrfB-3vc1A:
undetectable		 5zrfB-3vc1A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsz RICIN B LECTIN

(Ruminiclostridium
thermocellum) 		PF04616
(Glyco_hydro_43)
PF14200
(RicinB_lectin_2) 		4 GLY A  61
ASP A  62
ARG A  84
MET A 300
 None
 1.50A 5zrfB-3vszA:
undetectable		 5zrfB-3vszA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vz0 PUTATIVE
NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Gluconobacter
oxydans) 		PF00171
(Aldedh) 		4 GLY A 233
ASP A 235
GLN A 262
MET A  75
 None
 1.44A 5zrfB-3vz0A:
undetectable		 5zrfB-3vz0A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b1m LEVANASE

(Bacillus
subtilis) 		PF06439
(DUF1080) 		4 GLY A 573
ASP A 665
ARG A 572
GLN A 540
 None
 1.30A 5zrfB-4b1mA:
undetectable		 5zrfB-4b1mA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cr4 26S PROTEASE
REGULATORY SUBUNIT
6B HOMOLOG

(Saccharomyces
cerevisiae) 		PF00004
(AAA) 		4 GLY K 391
ASP K 406
ARG K 396
GLN K 414
 None
 1.27A 5zrfB-4cr4K:
undetectable		 5zrfB-4cr4K:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7q RALF,
PROLINE/BETAINE
TRANSPORTER

(Legionella
pneumophila;
Rickettsia
prowazekii) 		PF01369
(Sec7) 		4 ASP A 174
ARG A 167
GLN A 138
MET A 141
 None
 1.43A 5zrfB-4d7qA:
undetectable		 5zrfB-4d7qA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4db1 MYOSIN-7

(Homo sapiens) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		4 GLY A   2
ASP A   3
ARG A  17
GLN A  27
 None
 1.40A 5zrfB-4db1A:
undetectable		 5zrfB-4db1A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f9d POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE

(Escherichia
coli) 		PF01522
(Polysacc_deac_1)
PF14883
(GHL13) 		4 GLY A 461
ASP A 460
ARG A 529
MET A 377
 None
 1.38A 5zrfB-4f9dA:
undetectable		 5zrfB-4f9dA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ita SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE

(Synechococcus
sp. PCC 7002) 		PF00171
(Aldedh) 		4 GLY A 231
ASP A 233
GLN A 260
MET A  73
 None
 1.43A 5zrfB-4itaA:
undetectable		 5zrfB-4itaA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7h EVAA 2,3-DEHYDRATASE

(Amycolatopsis
orientalis) 		PF03559
(Hexose_dehydrat) 		4 GLY A 342
ASP A 341
ARG A 338
GLN A 438
 None
 1.48A 5zrfB-4j7hA:
undetectable		 5zrfB-4j7hA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jgi PUTATIVE
UNCHARACTERIZED
PROTEIN

(Desulfitobacterium
hafniense) 		PF02310
(B12-binding)
PF02607
(B12-binding_2) 		4 GLY A 202
ASP A 201
ARG A 208
GLN A  43
 COB  A 301 ( 4.1A)
None
None
None
 1.21A 5zrfB-4jgiA:
4.7		 5zrfB-4jgiA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica) 		PF13458
(Peripla_BP_6) 		4 GLY A 239
ASP A 242
ARG A 228
MET A 178
 None
 1.11A 5zrfB-4kv7A:
2.4		 5zrfB-4kv7A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lim DNA PRIMASE SMALL
SUBUNIT

(Saccharomyces
cerevisiae) 		PF01896
(DNA_primase_S) 		4 GLY A 166
ASP A 113
ARG A 164
MET A  15
 None
 1.34A 5zrfB-4limA:
undetectable		 5zrfB-4limA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7f FIBRINOGEN C
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00147
(Fibrinogen_C) 		4 GLY A 280
ASP A 274
ARG A 276
GLN A 252
 None
 1.18A 5zrfB-4m7fA:
undetectable		 5zrfB-4m7fA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m88 EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Verminephrobacter
eiseniae) 		PF13458
(Peripla_BP_6) 		4 GLY A   8
ASP A  49
GLN A  23
MET A 278
 None
 1.24A 5zrfB-4m88A:
2.3		 5zrfB-4m88A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nbr HYPOTHETICAL
3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE

(Brucella
abortus) 		PF13561
(adh_short_C2) 		4 GLY A  26
ASP A  50
ARG A  29
GLN A  37
 None
 1.33A 5zrfB-4nbrA:
2.6		 5zrfB-4nbrA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nte DEPH

(Chromobacterium
violaceum) 		PF07992
(Pyr_redox_2) 		4 GLY A  13
ASP A  35
ARG A  39
GLN A  68
 None
FAD  A 301 (-3.0A)
None
None
 1.19A 5zrfB-4nteA:
undetectable		 5zrfB-4nteA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4obs ALPHA-L-IDURONIDASE

(Homo sapiens) 		PF01229
(Glyco_hydro_39) 		4 GLY A 485
ASP A 484
ARG A 492
GLN A 500
 None
 1.28A 5zrfB-4obsA:
undetectable		 5zrfB-4obsA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE

(Streptococcus
pyogenes) 		PF00171
(Aldedh) 		4 GLY A 232
ASP A 234
GLN A 261
MET A  74
 None
 1.48A 5zrfB-4ohtA:
undetectable		 5zrfB-4ohtA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9a TAT PATHWAY SIGNAL
SEQUENCE DOMAIN
PROTEIN

(Parabacteroides
merdae) 		PF13472
(Lipase_GDSL_2) 		4 GLY A 181
ASP A 180
ARG A 179
MET A 248
 None
 1.12A 5zrfB-4q9aA:
3.4		 5zrfB-4q9aA:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfu GLYCOSIDE HYDROLASE
FAMILY 5

(Bacteroides
vulgatus) 		PF12904
(Collagen_bind_2)
PF13204
(DUF4038) 		4 GLY A 434
ASP A 433
ARG A 306
MET A 412
 None
 1.49A 5zrfB-4qfuA:
undetectable		 5zrfB-4qfuA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tvc DEXTRANSUCRASE

(Leuconostoc
mesenteroides) 		PF02324
(Glyco_hydro_70) 		4 GLY A2732
ASP A2654
ARG A2655
GLN A2742
 None
 1.50A 5zrfB-4tvcA:
undetectable		 5zrfB-4tvcA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upi SULFATASE FAMILY
PROTEIN

(Ruegeria
pomeroyi) 		PF00884
(Sulfatase) 		4 GLY A 100
ASP A 137
ARG A 209
GLN A 304
 None
 1.43A 5zrfB-4upiA:
undetectable		 5zrfB-4upiA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xcv NADP-DEPENDENT
2-HYDROXYACID
DEHYDROGENASE

(Rhizobium etli) 		PF02826
(2-Hacid_dh_C) 		4 GLY A 222
ASP A 221
ARG A 220
MET A 145
 None
 1.24A 5zrfB-4xcvA:
undetectable		 5zrfB-4xcvA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgt FRQ-INTERACTING RNA
HELICASE

(Neurospora
crassa) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		4 ASP A 256
ARG A1059
GLN A 238
MET A 545
 None
 1.34A 5zrfB-4xgtA:
3.6		 5zrfB-4xgtA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dbj FADH2-DEPENDENT
HALOGENASE PLTA

(Pseudomonas
protegens) 		no annotation 4 GLY E  84
ASP E  82
ARG E  99
GLN E 390
 None
 1.49A 5zrfB-5dbjE:
undetectable		 5zrfB-5dbjE:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ds0 PEPTIDASE M42

(Thaumarchaeota
archaeon SCGC
AB-539-E09) 		PF05343
(Peptidase_M42) 		4 GLY A  65
ASP A 181
ARG A 182
GLN A 213
 None
 1.49A 5zrfB-5ds0A:
3.1		 5zrfB-5ds0A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e0y SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis) 		PF03793
(PASTA) 		4 GLY A 625
ASP A 592
GLN A 606
MET A 563
 None
ZN  A 707 ( 2.8A)
None
None
 1.07A 5zrfB-5e0yA:
undetectable		 5zrfB-5e0yA:
7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e0z SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis) 		PF03793
(PASTA) 		4 GLY A 625
ASP A 592
GLN A 606
MET A 563
 None
 1.09A 5zrfB-5e0zA:
undetectable		 5zrfB-5e0zA:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ex1 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYCLOPHILIN TYPE

(Hirschia
baltica) 		PF00160
(Pro_isomerase) 		4 GLY A 214
ASP A 215
ARG A 198
GLN A  87
 None
 1.39A 5zrfB-5ex1A:
undetectable		 5zrfB-5ex1A:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fgu GREEN FLUORESCENT
PROTEIN,EXTRACELLULA
R STREPTODORNASE D

(Aequorea
victoria;
Streptococcus
pyogenes) 		PF01353
(GFP)
PF13930
(Endonuclea_NS_2) 		4 GLY A1135
ARG A1104
GLN A1210
MET A1221
 None
 1.12A 5zrfB-5fguA:
undetectable		 5zrfB-5fguA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fgw EXTRACELLULAR
STREPTODORNASE D

(Streptococcus
pyogenes) 		PF01223
(Endonuclease_NS) 		4 GLY A 135
ARG A 104
GLN A 210
MET A 221
 None
 1.20A 5zrfB-5fgwA:
undetectable		 5zrfB-5fgwA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h2t TREHALOSE SYNTHASE

(Thermomonospora
curvata) 		no annotation 4 GLY A  78
ASP A  77
ARG A  76
GLN A  72
 None
 1.42A 5zrfB-5h2tA:
undetectable		 5zrfB-5h2tA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hlb PENICILLIN-BINDING
PROTEIN 1B

(Escherichia
coli) 		PF00905
(Transpeptidase)
PF00912
(Transgly)
PF14814
(UB2H) 		4 GLY A 427
ASP A 428
GLN A 420
MET A 502
 None
 1.20A 5zrfB-5hlbA:
undetectable		 5zrfB-5hlbA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA

(Methylobacillus
flagellatus) 		PF00364
(Biotin_lipoyl)
PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		4 GLY C 374
ASP C 121
ARG C 398
MET C 429
 None
 1.25A 5zrfB-5ks8C:
undetectable		 5zrfB-5ks8C:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l8s AMINO ACYL PEPTIDASE

(Sporosarcina
psychrophila) 		PF00326
(Peptidase_S9) 		4 GLY A 571
ASP A 540
ARG A 542
MET A 388
 None
 1.37A 5zrfB-5l8sA:
2.7		 5zrfB-5l8sA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m04 GTPASE OBGE/CGTA

(Escherichia
coli) 		PF01018
(GTP1_OBG)
PF01926
(MMR_HSR1) 		4 GLY A  36
ASP A  77
ARG A  76
GLN A  71
 None
 1.37A 5zrfB-5m04A:
1.9		 5zrfB-5m04A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tgf UNCHARACTERIZED
PROTEIN

(Bacteroides
dorei) 		PF00144
(Beta-lactamase) 		4 GLY A 301
ASP A 300
ARG A 299
GLN A 238
 None
 1.10A 5zrfB-5tgfA:
undetectable		 5zrfB-5tgfA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj3 ALKALINE PHOSPHATASE
PAFA

(Elizabethkingia
meningoseptica) 		PF01663
(Phosphodiest) 		4 GLY A  53
ASP A 326
ARG A 327
GLN A 226
 None
 1.27A 5zrfB-5tj3A:
undetectable		 5zrfB-5tj3A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vfr PROTEASOME SUBUNIT
ALPHA TYPE-4

(Homo sapiens) 		no annotation 4 GLY I  42
ASP I  41
ARG I 218
GLN I 146
 None
 1.16A 5zrfB-5vfrI:
undetectable		 5zrfB-5vfrI:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wrh FLAGELLAR BASAL-BODY
ROD PROTEIN FLGG

(Salmonella
enterica) 		PF00460
(Flg_bb_rod)
PF06429
(Flg_bbr_C) 		4 GLY A 118
ASP A 117
ARG A 116
GLN A 104
 None
 1.14A 5zrfB-5wrhA:
undetectable		 5zrfB-5wrhA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjy ATP-BINDING CASSETTE
SUB-FAMILY A MEMBER
1

(Homo sapiens) 		PF00005
(ABC_tran)
PF12698
(ABC2_membrane_3) 		4 GLY A 592
ARG A 587
GLN A1380
MET A1383
 None
 1.05A 5zrfB-5xjyA:
undetectable		 5zrfB-5xjyA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c62 BIURET HYDROLASE

(Pseudomonas sp.
ADP) 		no annotation 4 GLY A 149
ASP A 121
ARG A 394
GLN A 402
 None
 1.29A 5zrfB-6c62A:
undetectable		 5zrfB-6c62A:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo sapiens) 		no annotation 4 GLY A 190
ASP A 187
GLN A 945
MET A 948
 None
None
ZQU  A1305 (-3.8A)
ZQU  A1305 (-3.4A)
 1.30A 5zrfB-6fn1A:
undetectable		 5zrfB-6fn1A:
8.86