SIMILAR PATTERNS OF AMINO ACIDS FOR 5ZRD_D_CUD607_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bt2 PROTEIN (CATECHOL
OXIDASE)

(Ipomoea batatas) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		4 HIS A 240
HIS A 244
HIS A 273
HIS A 274
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
None
C2O  A 500 ( 3.2A)
 0.31A 5zrdD-1bt2A:
4.5		 5zrdD-1bt2A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eqw CU,ZN SUPEROXIDE
DISMUTASE

(Salmonella
enterica) 		PF00080
(Sod_Cu) 		4 HIS A  44
HIS A 118
HIS A  46
HIS A  61
 CU  A 502 (-3.3A)
CU  A 502 (-3.1A)
CU  A 502 (-3.2A)
ZN  A 501 ( 3.2A)
 1.11A 5zrdD-1eqwA:
undetectable		 5zrdD-1eqwA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eso CU, ZN SUPEROXIDE
DISMUTASE

(Escherichia
coli) 		PF00080
(Sod_Cu) 		4 HIS A  44
HIS A 118
HIS A  46
HIS A  61
 CU  A 150 ( 3.2A)
CU  A 150 ( 3.2A)
CU  A 150 ( 3.3A)
ZN  A 149 ( 3.2A)
 1.17A 5zrdD-1esoA:
undetectable		 5zrdD-1esoA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hfu LACCASE 1

(Coprinopsis
cinerea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 453
HIS A 399
HIS A  66
HIS A 109
 CU  A 703 (-3.3A)
CU  A 702 ( 3.7A)
CU  A 703 (-3.0A)
CU  A 703 (-3.2A)
 1.07A 5zrdD-1hfuA:
undetectable		 5zrdD-1hfuA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js8 HEMOCYANIN

(Enteroctopus
dofleini) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS A2671
HIS A2675
HIS A2701
HIS A2702
 CUO  A 888 (-3.4A)
CUO  A 888 (-3.3A)
None
CUO  A 888 (-3.3A)
 0.26A 5zrdD-1js8A:
6.0		 5zrdD-1js8A:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 103
HIS A 980
HIS A 101
HIS A 161
 CU  A1051 (-3.3A)
CU  A1050 (-3.0A)
CU  A1052 (-3.2A)
CU  A1051 (-3.3A)
 1.10A 5zrdD-1kcwA:
undetectable		 5zrdD-1kcwA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lnl HEMOCYANIN

(Rapana venosa) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS A 181
HIS A 185
HIS A 211
HIS A 212
 CU  A5012 (-3.4A)
CU  A5012 (-3.2A)
None
CU  A5012 (-3.1A)
 0.63A 5zrdD-1lnlA:
4.9		 5zrdD-1lnlA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lnl HEMOCYANIN

(Rapana venosa) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS A 181
HIS A 185
HIS A 212
HIS A  70
 CU  A5012 (-3.4A)
CU  A5012 (-3.2A)
CU  A5012 (-3.1A)
CU  A5001 ( 3.1A)
 1.05A 5zrdD-1lnlA:
4.9		 5zrdD-1lnlA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lnl HEMOCYANIN

(Rapana venosa) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS A 212
HIS A  70
HIS A 181
HIS A 185
 CU  A5012 (-3.1A)
CU  A5001 ( 3.1A)
CU  A5012 (-3.4A)
CU  A5012 (-3.2A)
 1.16A 5zrdD-1lnlA:
4.9		 5zrdD-1lnlA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lox 15-LIPOXYGENASE

(Oryctolagus
cuniculus) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 HIS A 541
HIS A 545
HIS A 361
HIS A 366
 FE2  A 840 ( 3.4A)
FE2  A 840 (-3.3A)
FE2  A 840 (-3.3A)
FE2  A 840 (-3.4A)
 1.13A 5zrdD-1loxA:
3.3		 5zrdD-1loxA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oal SUPEROXIDE DISMUTASE

(Photobacterium
leiognathi) 		PF00080
(Sod_Cu) 		4 HIS A  45
HIS A 125
HIS A  47
HIS A  70
 CU  A 153 (-3.0A)
CU  A 153 (-3.2A)
CU  A 153 (-3.1A)
ZN  A 152 ( 3.1A)
 1.09A 5zrdD-1oalA:
undetectable		 5zrdD-1oalA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pss PHOTOSYNTHETIC
REACTION CENTER
PHOTOSYNTHETIC
REACTION CENTER

(Rhodobacter
sphaeroides;
Rhodobacter
sphaeroides) 		PF00124
(Photo_RC)
PF00124
(Photo_RC) 		4 HIS M 219
HIS M 266
HIS L 190
HIS L 230
 FE  M 302 ( 3.3A)
FE  M 302 (-3.3A)
FE  M 302 ( 3.3A)
FE  M 302 (-3.4A)
 1.16A 5zrdD-1pssM:
undetectable		 5zrdD-1pssM:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pzs SUPEROXIDE DISMUTASE
[CU-ZN]

(Mycobacterium
tuberculosis) 		PF00080
(Sod_Cu) 		4 HIS A  47
HIS A 126
HIS A  49
HIS A  75
 CU  A 172 (-3.1A)
CU  A 172 (-3.2A)
CU  A 172 (-3.2A)
CU  A 172 (-4.1A)
 1.15A 5zrdD-1pzsA:
undetectable		 5zrdD-1pzsA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)

(Homo sapiens) 		PF00650
(CRAL_TRIO)
PF03765
(CRAL_TRIO_N) 		4 HIS A 195
HIS A 236
HIS A 225
HIS A 223
 None
 1.07A 5zrdD-1r5lA:
undetectable		 5zrdD-1r5lA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wx4 TYROSINASE

(Streptomyces
castaneoglobisporus) 		PF00264
(Tyrosinase) 		4 HIS A 190
HIS A 194
HIS A 215
HIS A 216
 CU  A 401 ( 3.2A)
CU  A 401 ( 3.2A)
None
CU  A 401 ( 3.4A)
 0.22A 5zrdD-1wx4A:
4.6		 5zrdD-1wx4A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z9n SUPEROXIDE DISMUTASE
[CU-ZN]

([Haemophilus]
ducreyi) 		PF00080
(Sod_Cu) 		4 HIS A  70
HIS A 151
HIS A  72
HIS A  95
 CU  A 200 (-3.1A)
CU  A 200 (-3.2A)
CU  A 200 (-3.2A)
ZN  A 201 ( 3.1A)
 1.08A 5zrdD-1z9nA:
undetectable		 5zrdD-1z9nA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z9p SUPEROXIDE DISMUTASE
[CU-ZN]

([Haemophilus]
ducreyi) 		PF00080
(Sod_Cu) 		4 HIS A  70
HIS A 151
HIS A  72
HIS A  95
 CU  A 200 (-3.1A)
CU  A 200 (-3.2A)
CU  A 200 (-3.2A)
ZN  A 201 ( 3.1A)
 1.11A 5zrdD-1z9pA:
undetectable		 5zrdD-1z9pA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aps PROTEIN (CU,ZN
SUPEROXIDE
DISMUTASE)

(Actinobacillus
pleuropneumoniae) 		PF00080
(Sod_Cu) 		4 HIS A  60
HIS A 141
HIS A  62
HIS A  85
 CU  A 402 ( 3.3A)
CU  A 402 ( 3.1A)
CU  A 402 ( 3.4A)
ZN  A 400 (-3.2A)
 1.11A 5zrdD-2apsA:
undetectable		 5zrdD-2apsA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aqt SUPEROXIDE DISMUTASE
[CU-ZN]

(Neisseria
meningitidis) 		no annotation 4 HIS C  79
HIS C 160
HIS C  81
HIS C 104
 CU1  C 200 (-3.1A)
CU1  C 200 (-3.2A)
CU1  C 200 (-3.3A)
ZN  C 201 ( 3.1A)
 1.09A 5zrdD-2aqtC:
undetectable		 5zrdD-2aqtC:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e47 TIME INTERVAL
MEASURING ENZYME
TIME

(Bombyx mori) 		PF00080
(Sod_Cu) 		4 HIS A  50
HIS A 124
HIS A  52
HIS A  67
 CU  A 171 (-3.1A)
CU  A 171 (-3.2A)
CU  A 171 (-3.2A)
ZN  A 172 ( 3.1A)
 1.14A 5zrdD-2e47A:
undetectable		 5zrdD-2e47A:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jlp EXTRACELLULAR
SUPEROXIDE DISMUTASE
(CU-ZN)

(Homo sapiens) 		PF00080
(Sod_Cu) 		4 HIS A  96
HIS A 163
HIS A  98
HIS A 113
 CU  A 225 (-3.2A)
CU  A 225 (-3.2A)
CU  A 225 (-3.2A)
ZN  A 226 ( 3.1A)
 1.14A 5zrdD-2jlpA:
undetectable		 5zrdD-2jlpA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3x POLYPHENOL OXIDASE,
CHLOROPLAST

(Vitis vinifera) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		4 HIS A 239
HIS A 243
HIS A 271
HIS A 272
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
None
C2O  A 340 (-3.1A)
 0.20A 5zrdD-2p3xA:
4.2		 5zrdD-2p3xA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2paj PUTATIVE
CYTOSINE/GUANINE
DEAMINASE

(unidentified) 		PF01979
(Amidohydro_1) 		4 HIS A 137
HIS A 248
HIS A  76
HIS A  78
 None
ZN  A 493 (-3.2A)
ZN  A 493 (-3.5A)
ZN  A 493 (-3.2A)
 1.06A 5zrdD-2pajA:
undetectable		 5zrdD-2pajA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2paj PUTATIVE
CYTOSINE/GUANINE
DEAMINASE

(unidentified) 		PF01979
(Amidohydro_1) 		4 HIS A 248
HIS A  76
HIS A 137
HIS A  78
 ZN  A 493 (-3.2A)
ZN  A 493 (-3.5A)
None
ZN  A 493 (-3.2A)
 1.08A 5zrdD-2pajA:
undetectable		 5zrdD-2pajA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2paj PUTATIVE
CYTOSINE/GUANINE
DEAMINASE

(unidentified) 		PF01979
(Amidohydro_1) 		4 HIS A 248
HIS A 285
HIS A  76
HIS A  78
 ZN  A 493 (-3.2A)
ZN  A 493 (-3.5A)
ZN  A 493 (-3.5A)
ZN  A 493 (-3.2A)
 0.92A 5zrdD-2pajA:
undetectable		 5zrdD-2pajA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qt3 N-ISOPROPYLAMMELIDE
ISOPROPYL
AMIDOHYDROLASE

(Pseudomonas sp.
ADP) 		PF01979
(Amidohydro_1) 		4 HIS A  60
HIS A  62
HIS A 125
HIS A 217
 ZN  A 501 (-3.3A)
ZN  A 501 (-3.3A)
None
ZN  A 501 (-3.5A)
 1.02A 5zrdD-2qt3A:
undetectable		 5zrdD-2qt3A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wwo SUPEROXIDE DISMUTASE
[CU-ZN]

(Yersinia
pseudotuberculosis) 		PF00080
(Sod_Cu) 		4 HIS A  54
HIS A 135
HIS A  56
HIS A  79
 ZN  A1165 (-3.3A)
ZN  A1165 (-3.3A)
ZN  A1165 (-3.4A)
ZN  A1162 ( 3.2A)
 1.15A 5zrdD-2wwoA:
undetectable		 5zrdD-2wwoA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9x POLYPHENOL OXIDASE

(Agaricus
bisporus) 		PF00264
(Tyrosinase) 		4 HIS A 259
HIS A 263
HIS A 295
HIS A 296
 CU  A 401 (-3.2A)
0TR  A 410 ( 3.1A)
None
CU  A 401 (-3.2A)
 0.36A 5zrdD-2y9xA:
27.6		 5zrdD-2y9xA:
26.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eyy PUTATIVE IRON UPTAKE
REGULATORY PROTEIN

(Streptomyces
coelicolor) 		PF01475
(FUR) 		4 HIS A  86
HIS A  33
HIS A  90
HIS A  88
 ZN  A 147 (-3.3A)
ZN  A 147 (-3.3A)
ZN  A 147 (-3.3A)
ZN  A 147 (-3.7A)
 1.12A 5zrdD-3eyyA:
undetectable		 5zrdD-3eyyA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE

(Alvinella
pompejana) 		PF00080
(Sod_Cu) 		4 HIS A  44
HIS A 118
HIS A  46
HIS A  61
 CU  A 202 ( 2.9A)
CU1  A 201 ( 3.2A)
CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
 1.10A 5zrdD-3f7lA:
undetectable		 5zrdD-3f7lA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcm HYDROLASE, NUDIX
FAMILY

(Clostridium
perfringens) 		PF00293
(NUDIX) 		4 HIS A 129
HIS A  75
HIS A  43
HIS A 127
 MN  A 201 (-3.5A)
MN  A 201 (-3.3A)
MN  A 201 (-3.4A)
MN  A 201 (-3.6A)
 0.99A 5zrdD-3fcmA:
undetectable		 5zrdD-3fcmA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fsn RETINAL PIGMENT
EPITHELIUM-SPECIFIC
65 KDA PROTEIN

(Bos taurus) 		PF03055
(RPE65) 		4 HIS A 313
HIS A 527
HIS A 180
HIS A 241
 FE2  A 534 (-3.4A)
FE2  A 534 (-3.3A)
FE2  A 534 (-3.4A)
FE2  A 534 (-3.3A)
 1.05A 5zrdD-3fsnA:
undetectable		 5zrdD-3fsnA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g77 CYTOSINE DEAMINASE

(Escherichia
coli) 		PF07969
(Amidohydro_3) 		4 HIS A  61
HIS A  63
HIS A 122
HIS A 214
 FE  A 502 (-3.1A)
FE  A 502 (-3.1A)
None
FE  A 502 (-3.6A)
 0.99A 5zrdD-3g77A:
undetectable		 5zrdD-3g77A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpa AMIDOHYDROLASE

(unidentified) 		PF01979
(Amidohydro_1) 		4 HIS A  95
HIS A 153
HIS A  93
HIS A 259
 ZN  A 480 (-3.3A)
None
ZN  A 480 (-3.3A)
ZN  A 480 (-3.5A)
 1.15A 5zrdD-3hpaA:
undetectable		 5zrdD-3hpaA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpa AMIDOHYDROLASE

(unidentified) 		PF01979
(Amidohydro_1) 		4 HIS A 153
HIS A 259
HIS A  93
HIS A  95
 None
ZN  A 480 (-3.5A)
ZN  A 480 (-3.3A)
ZN  A 480 (-3.3A)
 0.98A 5zrdD-3hpaA:
undetectable		 5zrdD-3hpaA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ht1 REMF PROTEIN

(Streptomyces
resistomycificus) 		PF07883
(Cupin_2) 		4 HIS A  55
HIS A  53
HIS A  95
HIS A  59
 NI  A 151 (-3.3A)
NI  A 151 (-3.3A)
NI  A 151 (-3.3A)
NI  A 151 (-3.3A)
 0.93A 5zrdD-3ht1A:
undetectable		 5zrdD-3ht1A:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ht1 REMF PROTEIN

(Streptomyces
resistomycificus) 		PF07883
(Cupin_2) 		4 HIS A  95
HIS A  59
HIS A  55
HIS A  53
 NI  A 151 (-3.3A)
NI  A 151 (-3.3A)
NI  A 151 (-3.3A)
NI  A 151 (-3.3A)
 1.17A 5zrdD-3ht1A:
undetectable		 5zrdD-3ht1A:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kbe SUPEROXIDE DISMUTASE
[CU-ZN]

(Caenorhabditis
elegans) 		PF00080
(Sod_Cu) 		4 HIS A  45
HIS A 119
HIS A  47
HIS A  62
 None
 1.14A 5zrdD-3kbeA:
undetectable		 5zrdD-3kbeA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3km2 SUPEROXIDE DISMUTASE
[CU-ZN],
CHLOROPLASTIC

(Solanum
lycopersicum) 		PF00080
(Sod_Cu) 		4 HIS A  46
HIS A 120
HIS A  48
HIS A  63
 None
None
None
ZN  A 155 (-3.2A)
 1.17A 5zrdD-3km2A:
undetectable		 5zrdD-3km2A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l9y SUPEROXIDE DISMUTASE
[CU-ZN]

(Bombyx mori) 		PF00080
(Sod_Cu) 		4 HIS A  45
HIS A 120
HIS A  47
HIS A  62
 CU  A 156 (-3.2A)
CU  A 156 (-3.1A)
CU  A 156 (-3.2A)
ZN  A 155 ( 3.1A)
 1.11A 5zrdD-3l9yA:
undetectable		 5zrdD-3l9yA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mnd SUPEROXIDE DISMUTASE
[CU-ZN]

(Taenia solium) 		PF00080
(Sod_Cu) 		4 HIS A  43
HIS A 117
HIS A  45
HIS A  60
 CU  A 155 (-3.1A)
CU  A 155 (-3.4A)
CU  A 155 (-3.5A)
ZN  A 153 ( 3.1A)
 1.16A 5zrdD-3mndA:
undetectable		 5zrdD-3mndA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rde ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE

(Sus scrofa) 		PF00305
(Lipoxygenase) 		4 HIS A 541
HIS A 545
HIS A 361
HIS A 366
 FE2  A   1 (-3.3A)
FE2  A   1 (-3.3A)
FE2  A   1 ( 3.4A)
FE2  A   1 ( 3.4A)
 1.11A 5zrdD-3rdeA:
undetectable		 5zrdD-3rdeA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6q TYROSINASE

(Aspergillus
oryzae) 		PF00264
(Tyrosinase) 		4 HIS A 328
HIS A 332
HIS A 371
HIS A 372
 None
 0.29A 5zrdD-3w6qA:
7.6		 5zrdD-3w6qA:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS A 179
HIS A 183
HIS A 209
HIS A 210
 CUO  A9001 (-3.4A)
CUO  A9001 (-3.4A)
None
CUO  A9001 (-3.3A)
 0.72A 5zrdD-4bedA:
4.4		 5zrdD-4bedA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS A 602
HIS A 606
HIS A 632
HIS A 633
 CUO  A9002 (-3.4A)
CUO  A9002 (-3.3A)
None
CUO  A9002 (-3.3A)
 0.85A 5zrdD-4bedA:
4.4		 5zrdD-4bedA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS A1015
HIS A1019
HIS A1045
HIS A1046
 CUO  A9003 (-3.1A)
CUO  A9003 (-3.4A)
None
CUO  A9003 (-3.2A)
 0.76A 5zrdD-4bedA:
4.4		 5zrdD-4bedA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS A1424
HIS A1428
HIS A1454
HIS A1455
 CUO  A9004 (-3.0A)
CUO  A9004 (-3.4A)
None
CUO  A9004 (-3.3A)
 0.77A 5zrdD-4bedA:
4.4		 5zrdD-4bedA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS B1847
HIS B1851
HIS B1877
HIS B1878
 CUO  B9005 (-3.2A)
CUO  B9005 (-3.2A)
None
CUO  B9005 (-3.3A)
 0.78A 5zrdD-4bedB:
27.6		 5zrdD-4bedB:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS B2260
HIS B2264
HIS B2290
HIS B2291
 CUO  B9006 (-3.2A)
CUO  B9006 (-3.2A)
None
CUO  B9006 (-3.5A)
 0.81A 5zrdD-4bedB:
27.6		 5zrdD-4bedB:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS B2291
HIS B2150
HIS B2260
HIS B2264
 CUO  B9006 (-3.5A)
CUO  B9006 (-3.3A)
CUO  B9006 (-3.2A)
CUO  B9006 (-3.2A)
 0.86A 5zrdD-4bedB:
27.6		 5zrdD-4bedB:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS B2670
HIS B2674
HIS B2700
HIS B2701
 CUO  B9007 (-3.4A)
CUO  B9007 (-3.4A)
None
CUO  B9007 (-3.1A)
 0.74A 5zrdD-4bedB:
27.6		 5zrdD-4bedB:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bif CUPIN 2 CONSERVED
BARREL DOMAIN
PROTEIN

(Granulicella
tundricola) 		PF07883
(Cupin_2) 		4 HIS A  53
HIS A  96
HIS A  94
HIS A  55
 MN  A1132 (-3.3A)
MN  A1132 (-3.4A)
MN  A1132 (-3.6A)
MN  A1132 (-3.4A)
 1.05A 5zrdD-4bifA:
undetectable		 5zrdD-4bifA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i7h PEROXIDE STRESS
SENSING REGULATOR

(Streptococcus
pyogenes) 		PF01475
(FUR) 		4 HIS A   4
HIS A  97
HIS A  99
HIS A   6
 NI  A 201 (-3.6A)
NI  A 201 (-3.6A)
NI  A 201 (-3.5A)
NI  A 201 (-3.6A)
 0.84A 5zrdD-4i7hA:
undetectable		 5zrdD-4i7hA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i7h PEROXIDE STRESS
SENSING REGULATOR

(Streptococcus
pyogenes) 		PF01475
(FUR) 		4 HIS A   4
HIS A  99
HIS A   6
HIS A  19
 NI  A 201 (-3.6A)
NI  A 201 (-3.5A)
NI  A 201 (-3.6A)
NI  A 201 (-3.5A)
 1.12A 5zrdD-4i7hA:
undetectable		 5zrdD-4i7hA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3q CATECHOL OXIDASE

(Aspergillus
oryzae) 		PF00264
(Tyrosinase) 		4 HIS A 284
HIS A 288
HIS A 311
HIS A 312
 CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
None
CU  A1002 (-3.2A)
 0.41A 5zrdD-4j3qA:
18.2		 5zrdD-4j3qA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l05 SUPEROXIDE DISMUTASE
[CU-ZN]

(Brucella
abortus) 		PF00080
(Sod_Cu) 		4 HIS A  48
HIS A 128
HIS A  50
HIS A  73
 CU1  A 201 ( 3.1A)
CU1  A 201 ( 3.2A)
CU1  A 201 ( 3.2A)
ZN  A 203 (-3.1A)
 1.18A 5zrdD-4l05A:
undetectable		 5zrdD-4l05A:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oja SUPEROXIDE DISMUTASE
[CU-ZN]

(Hydra vulgaris) 		PF00080
(Sod_Cu) 		4 HIS A  45
HIS A 119
HIS A  47
HIS A  62
 CU  A 201 (-3.4A)
CU  A 201 (-3.2A)
CU  A 201 (-3.3A)
ZN  A 202 ( 3.2A)
 1.16A 5zrdD-4ojaA:
undetectable		 5zrdD-4ojaA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oua LATENT FORM OF PPO4
TYROSINASE

(Agaricus
bisporus) 		PF00264
(Tyrosinase) 		4 HIS B 251
HIS B 255
HIS B 282
HIS B 283
 CU1  B 602 (-3.2A)
CU1  B 602 (-3.1A)
None
CU1  B 602 (-3.0A)
 0.19A 5zrdD-4ouaB:
6.5		 5zrdD-4ouaB:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE

(Agaricus
bisporus) 		PF00264
(Tyrosinase) 		4 HIS A 251
HIS A 255
HIS A 282
HIS A 283
 CU1  A 402 (-3.0A)
CU1  A 402 (-3.1A)
CU1  A 402 (-3.0A)
CU1  A 402 (-2.9A)
 0.26A 5zrdD-4ouaA:
5.4		 5zrdD-4ouaA:
27.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r85 CYTOSINE DEAMINASE

(Klebsiella
pneumoniae) 		PF07969
(Amidohydro_3) 		4 HIS A  56
HIS A  58
HIS A 117
HIS A 209
 FE2  A 502 (-3.4A)
FE2  A 502 ( 3.5A)
None
FE2  A 502 ( 3.4A)
 1.09A 5zrdD-4r85A:
undetectable		 5zrdD-4r85A:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r85 CYTOSINE DEAMINASE

(Klebsiella
pneumoniae) 		PF07969
(Amidohydro_3) 		4 HIS A  56
HIS A  58
HIS A 209
HIS A 241
 FE2  A 502 (-3.4A)
FE2  A 502 ( 3.5A)
FE2  A 502 ( 3.4A)
FE2  A 502 ( 3.7A)
 1.17A 5zrdD-4r85A:
undetectable		 5zrdD-4r85A:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r85 CYTOSINE DEAMINASE

(Klebsiella
pneumoniae) 		PF07969
(Amidohydro_3) 		4 HIS A 209
HIS A 241
HIS A  56
HIS A  58
 FE2  A 502 ( 3.4A)
FE2  A 502 ( 3.7A)
FE2  A 502 (-3.4A)
FE2  A 502 ( 3.5A)
 1.01A 5zrdD-4r85A:
undetectable		 5zrdD-4r85A:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uxa CUPIN 2 CONSERVED
BARREL DOMAIN
PROTEIN

(Granulicella
tundricola) 		PF07883
(Cupin_2) 		4 HIS A  53
HIS A  96
HIS A  94
HIS A  55
 MN  A 200 (-3.6A)
MN  A 200 (-3.7A)
MN  A 200 (-3.6A)
MN  A 200 (-3.7A)
 1.17A 5zrdD-4uxaA:
undetectable		 5zrdD-4uxaA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ymk ACYL-COA DESATURASE
1

(Mus musculus) 		PF00487
(FA_desaturase) 		4 HIS A 116
HIS A 297
HIS A 121
HIS A 153
 ZN  A 401 ( 3.5A)
ZN  A 401 (-3.2A)
ZN  A 401 (-3.4A)
ZN  A 401 ( 3.2A)
 1.15A 5zrdD-4ymkA:
undetectable		 5zrdD-4ymkA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ymk ACYL-COA DESATURASE
1

(Mus musculus) 		PF00487
(FA_desaturase) 		4 HIS A 153
HIS A 116
HIS A 121
HIS A 157
 ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.5A)
ZN  A 401 (-3.4A)
ZN  A 401 (-3.3A)
 1.05A 5zrdD-4ymkA:
undetectable		 5zrdD-4ymkA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ymk ACYL-COA DESATURASE
1

(Mus musculus) 		PF00487
(FA_desaturase) 		4 HIS A 157
HIS A 153
HIS A 121
HIS A 297
 ZN  A 401 (-3.3A)
ZN  A 401 ( 3.2A)
ZN  A 401 (-3.4A)
ZN  A 401 (-3.2A)
 0.95A 5zrdD-4ymkA:
undetectable		 5zrdD-4ymkA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z11 AURONE SYNTHASE

(Coreopsis
grandiflora) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL)
PF12143
(PPO1_KFDV) 		4 HIS A 252
HIS A 256
HIS A 285
HIS A 286
 CU  A 701 (-3.1A)
CU  A 701 (-3.1A)
None
CU  A 701 (-3.1A)
 0.22A 5zrdD-4z11A:
4.4		 5zrdD-4z11A:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr0 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		4 HIS A 244
HIS A 348
HIS A 249
HIS A 268
 ZN  A 402 (-3.7A)
ZN  A 402 (-3.3A)
ZN  A 402 (-3.2A)
ZN  A 402 (-3.5A)
 1.09A 5zrdD-4zr0A:
undetectable		 5zrdD-4zr0A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr0 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		4 HIS A 249
HIS A 244
HIS A 348
HIS A 272
 ZN  A 402 (-3.2A)
ZN  A 402 (-3.7A)
ZN  A 402 (-3.3A)
ZN  A 402 (-3.4A)
 1.17A 5zrdD-4zr0A:
undetectable		 5zrdD-4zr0A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr0 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		4 HIS A 249
HIS A 268
HIS A 244
HIS A 348
 ZN  A 402 (-3.2A)
ZN  A 402 (-3.5A)
ZN  A 402 (-3.7A)
ZN  A 402 (-3.3A)
 1.06A 5zrdD-4zr0A:
undetectable		 5zrdD-4zr0A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr0 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		4 HIS A 268
HIS A 244
HIS A 249
HIS A 272
 ZN  A 402 (-3.5A)
ZN  A 402 (-3.7A)
ZN  A 402 (-3.2A)
ZN  A 402 (-3.4A)
 1.15A 5zrdD-4zr0A:
undetectable		 5zrdD-4zr0A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr0 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		4 HIS A 330
HIS A 326
HIS A 271
HIS A 349
 ZN  A 401 (-3.3A)
ZN  A 401 (-3.4A)
ZN  A 401 (-3.2A)
ZN  A 401 (-3.2A)
 1.10A 5zrdD-4zr0A:
undetectable		 5zrdD-4zr0A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr0 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		4 HIS A 330
HIS A 345
HIS A 326
HIS A 271
 ZN  A 401 (-3.3A)
ZN  A 401 (-3.5A)
ZN  A 401 (-3.4A)
ZN  A 401 (-3.2A)
 1.11A 5zrdD-4zr0A:
undetectable		 5zrdD-4zr0A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr0 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		4 HIS A 345
HIS A 326
HIS A 330
HIS A 349
 ZN  A 401 (-3.5A)
ZN  A 401 (-3.4A)
ZN  A 401 (-3.3A)
ZN  A 401 (-3.2A)
 0.97A 5zrdD-4zr0A:
undetectable		 5zrdD-4zr0A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr0 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		4 HIS A 348
HIS A 272
HIS A 249
HIS A 244
 ZN  A 402 (-3.3A)
ZN  A 402 (-3.4A)
ZN  A 402 (-3.2A)
ZN  A 402 (-3.7A)
 1.17A 5zrdD-4zr0A:
undetectable		 5zrdD-4zr0A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr0 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		4 HIS A 349
HIS A 345
HIS A 330
HIS A 271
 ZN  A 401 (-3.2A)
ZN  A 401 (-3.5A)
ZN  A 401 (-3.3A)
ZN  A 401 (-3.2A)
 1.03A 5zrdD-4zr0A:
undetectable		 5zrdD-4zr0A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		4 HIS A 244
HIS A 348
HIS A 249
HIS A 268
 ZN  A 402 (-3.5A)
ZN  A 402 (-3.3A)
ZN  A 402 (-3.2A)
ZN  A 402 (-3.3A)
 1.13A 5zrdD-4zr1A:
undetectable		 5zrdD-4zr1A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		4 HIS A 249
HIS A 268
HIS A 244
HIS A 348
 ZN  A 402 (-3.2A)
ZN  A 402 (-3.3A)
ZN  A 402 (-3.5A)
ZN  A 402 (-3.3A)
 1.04A 5zrdD-4zr1A:
undetectable		 5zrdD-4zr1A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		4 HIS A 268
HIS A 244
HIS A 249
HIS A 272
 ZN  A 402 (-3.3A)
ZN  A 402 (-3.5A)
ZN  A 402 (-3.2A)
ZN  A 402 (-3.5A)
 1.14A 5zrdD-4zr1A:
undetectable		 5zrdD-4zr1A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		4 HIS A 272
HIS A 268
HIS A 249
HIS A 348
 ZN  A 402 (-3.5A)
ZN  A 402 (-3.3A)
ZN  A 402 (-3.2A)
ZN  A 402 (-3.3A)
 1.08A 5zrdD-4zr1A:
undetectable		 5zrdD-4zr1A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		4 HIS A 330
HIS A 326
HIS A 271
HIS A 349
 ZN  A 401 (-3.3A)
ZN  A 401 (-3.5A)
ZN  A 401 ( 3.4A)
ZN  A 401 (-3.2A)
 1.10A 5zrdD-4zr1A:
undetectable		 5zrdD-4zr1A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		4 HIS A 330
HIS A 345
HIS A 326
HIS A 271
 ZN  A 401 (-3.3A)
ZN  A 401 (-3.4A)
ZN  A 401 (-3.5A)
ZN  A 401 ( 3.4A)
 1.09A 5zrdD-4zr1A:
undetectable		 5zrdD-4zr1A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		4 HIS A 330
HIS A 349
HIS A 345
HIS A 326
 ZN  A 401 (-3.3A)
ZN  A 401 (-3.2A)
ZN  A 401 (-3.4A)
ZN  A 401 (-3.5A)
 1.10A 5zrdD-4zr1A:
undetectable		 5zrdD-4zr1A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		4 HIS A 345
HIS A 326
HIS A 330
HIS A 349
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.5A)
ZN  A 401 (-3.3A)
ZN  A 401 (-3.2A)
 0.98A 5zrdD-4zr1A:
undetectable		 5zrdD-4zr1A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		4 HIS A 349
HIS A 345
HIS A 330
HIS A 271
 ZN  A 401 (-3.2A)
ZN  A 401 (-3.4A)
ZN  A 401 (-3.3A)
ZN  A 401 ( 3.4A)
 1.01A 5zrdD-4zr1A:
undetectable		 5zrdD-4zr1A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zyo ACYL-COA DESATURASE

(Homo sapiens) 		no annotation 4 HIS A 125
HIS A 120
HIS A 301
HIS A 161
 ZN  A 401 (-3.2A)
ZN  A 401 ( 3.3A)
ZN  A 401 (-3.4A)
ZN  A 401 (-3.3A)
 1.11A 5zrdD-4zyoA:
undetectable		 5zrdD-4zyoA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zyo ACYL-COA DESATURASE

(Homo sapiens) 		no annotation 4 HIS A 125
HIS A 157
HIS A 120
HIS A 301
 ZN  A 401 (-3.2A)
ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.3A)
ZN  A 401 (-3.4A)
 1.12A 5zrdD-4zyoA:
undetectable		 5zrdD-4zyoA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zyo ACYL-COA DESATURASE

(Homo sapiens) 		no annotation 4 HIS A 157
HIS A 120
HIS A 125
HIS A 161
 ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.3A)
ZN  A 401 (-3.2A)
ZN  A 401 (-3.3A)
 1.07A 5zrdD-4zyoA:
undetectable		 5zrdD-4zyoA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zyo ACYL-COA DESATURASE

(Homo sapiens) 		no annotation 4 HIS A 160
HIS A 269
HIS A 298
HIS A 302
 ZN  A 402 (-3.2A)
ZN  A 402 (-3.2A)
ZN  A 402 (-3.3A)
ZN  A 402 (-3.5A)
 1.02A 5zrdD-4zyoA:
undetectable		 5zrdD-4zyoA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zyo ACYL-COA DESATURASE

(Homo sapiens) 		no annotation 4 HIS A 161
HIS A 157
HIS A 125
HIS A 301
 ZN  A 401 (-3.3A)
ZN  A 401 ( 3.2A)
ZN  A 401 (-3.2A)
ZN  A 401 (-3.4A)
 1.07A 5zrdD-4zyoA:
undetectable		 5zrdD-4zyoA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ce9 POLYPHENOL OXIDASE

(Juglans regia) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		4 HIS A 239
HIS A 243
HIS A 272
HIS A 273
 CU  A 401 ( 3.2A)
CU  A 401 ( 3.2A)
None
CU  A 401 ( 3.2A)
 0.26A 5zrdD-5ce9A:
4.4		 5zrdD-5ce9A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g3f THERMUS THERMOPHILUS
MULTICOPPER OXIDASE

(Thermus
thermophilus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 398
HIS A 444
HIS A 137
HIS A  95
 CU  A1463 (-2.9A)
CU  A1463 (-3.0A)
CU  A1463 (-3.3A)
CU  A1463 (-4.1A)
 1.17A 5zrdD-5g3fA:
undetectable		 5zrdD-5g3fA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3a TYROSINASE

(Bacillus
megaterium) 		PF00264
(Tyrosinase) 		4 HIS A 204
HIS A 208
HIS A 230
HIS A 231
 ZN  A 302 ( 3.4A)
HQE  A 303 ( 3.0A)
None
ZN  A 302 (-3.1A)
 0.17A 5zrdD-5i3aA:
5.0		 5zrdD-5i3aA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5in2 EXTRACELLULAR
SUPEROXIDE DISMUTASE
[CU-ZN]

(Onchocerca
volvulus) 		PF00080
(Sod_Cu) 		4 HIS A  46
HIS A 120
HIS A  48
HIS A  63
 CU  A 203 ( 3.1A)
CU  A 203 ( 3.1A)
CU  A 203 ( 3.2A)
ZN  A 202 (-3.1A)
 1.18A 5zrdD-5in2A:
undetectable		 5zrdD-5in2A:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j55 CAROTENOID OXYGENASE

(Novosphingobium
aromaticivorans) 		PF03055
(RPE65) 		4 HIS A 284
HIS A 476
HIS A 167
HIS A 218
 FE  A 501 ( 3.3A)
FE  A 501 ( 3.1A)
FE  A 501 (-3.3A)
FE  A 501 (-3.2A)
 0.93A 5zrdD-5j55A:
undetectable		 5zrdD-5j55A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5

(Candida
albicans) 		PF00080
(Sod_Cu) 		4 HIS A  75
HIS A 153
HIS A  77
HIS A  93
 CU1  A 201 (-3.0A)
CU1  A 201 (-3.2A)
CU1  A 201 (-3.1A)
CU1  A 201 (-4.2A)
 1.11A 5zrdD-5kbmA:
undetectable		 5zrdD-5kbmA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mue ALPHA-TOCOPHEROL
TRANSFER PROTEIN

(Homo sapiens) 		PF00650
(CRAL_TRIO)
PF03765
(CRAL_TRIO_N) 		4 HIS A 195
HIS A 236
HIS A 225
HIS A 223
 None
None
CL  A 303 (-4.0A)
CL  A 303 ( 4.9A)
 1.10A 5zrdD-5mueA:
undetectable		 5zrdD-5mueA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5or4 CATECHOL OXIDASE

(Aspergillus
oryzae) 		no annotation 4 HIS A 284
HIS A 288
HIS A 311
HIS A 312
 CU  A2002 (-3.2A)
CU  A2002 (-3.2A)
None
CU  A2002 (-3.1A)
 0.45A 5zrdD-5or4A:
4.0		 5zrdD-5or4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8z CAROTENOID OXYGENASE
1

(Neurospora
crassa) 		PF03055
(RPE65) 		4 HIS A 313
HIS A 510
HIS A 197
HIS A 248
 FE2  A 601 ( 3.4A)
FE2  A 601 (-3.3A)
FE2  A 601 (-3.3A)
FE2  A 601 ( 3.4A)
 1.04A 5zrdD-5u8zA:
undetectable		 5zrdD-5u8zA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v2d DIOXYGENASE

(Pseudomonas
brassicacearum) 		no annotation 4 HIS A 284
HIS A 475
HIS A 168
HIS A 219
 FE  A 500 (-3.3A)
FE  A 500 (-3.3A)
FE  A 500 (-3.3A)
FE  A 500 (-3.2A)
 1.00A 5zrdD-5v2dA:
undetectable		 5zrdD-5v2dA:
undetectable