SIMILAR PATTERNS OF AMINO ACIDS FOR 5ZRD_B_CUB607_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bt2 PROTEIN (CATECHOL
OXIDASE)

(Ipomoea batatas) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		4 HIS A  88
CYH A  92
HIS A 109
PHE A 270
 C2O  A 500 ( 3.2A)
C2O  A 500 (-3.5A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 4.8A)
 1.07A 5zrdB-1bt2A:
undetectable		 5zrdB-1bt2A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bt2 PROTEIN (CATECHOL
OXIDASE)

(Ipomoea batatas) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		4 HIS A  88
HIS A 109
HIS A 118
PHE A 270
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 4.8A)
 0.31A 5zrdB-1bt2A:
undetectable		 5zrdB-1bt2A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bt2 PROTEIN (CATECHOL
OXIDASE)

(Ipomoea batatas) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		4 HIS A 240
HIS A 244
HIS A 274
PHE A 114
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
None
 1.07A 5zrdB-1bt2A:
undetectable		 5zrdB-1bt2A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dfx DESULFOFERRODOXIN

(Desulfovibrio
desulfuricans) 		PF01880
(Desulfoferrodox)
PF06397
(Desulfoferrod_N) 		4 HIS A  48
CYH A 115
HIS A  74
HIS A  68
 FE  A 132 (-3.4A)
FE  A 132 (-2.2A)
FE  A 132 (-3.4A)
FE  A 132 (-3.2A)
 1.19A 5zrdB-1dfxA:
undetectable		 5zrdB-1dfxA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dfx DESULFOFERRODOXIN

(Desulfovibrio
desulfuricans) 		PF01880
(Desulfoferrodox)
PF06397
(Desulfoferrod_N) 		4 HIS A 118
CYH A 115
HIS A  74
HIS A  68
 FE  A 132 (-3.2A)
FE  A 132 (-2.2A)
FE  A 132 (-3.4A)
FE  A 132 (-3.2A)
 1.19A 5zrdB-1dfxA:
undetectable		 5zrdB-1dfxA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1do6 SUPEROXIDE REDUCTASE

(Pyrococcus
furiosus) 		PF01880
(Desulfoferrodox) 		4 HIS A  16
CYH A 111
HIS A  47
HIS A  41
 FE  A 200 (-3.3A)
FE  A 200 (-2.4A)
FE  A 200 (-3.4A)
FE  A 200 (-3.3A)
 1.17A 5zrdB-1do6A:
2.8		 5zrdB-1do6A:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1do6 SUPEROXIDE REDUCTASE

(Pyrococcus
furiosus) 		PF01880
(Desulfoferrodox) 		4 HIS A 114
CYH A 111
HIS A  47
HIS A  41
 FE  A 200 (-3.2A)
FE  A 200 (-2.4A)
FE  A 200 (-3.4A)
FE  A 200 (-3.3A)
 1.17A 5zrdB-1do6A:
2.8		 5zrdB-1do6A:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4a L-FUCULOSE
1-PHOSPHATE ALDOLASE

(Escherichia
coli) 		PF00596
(Aldolase_II) 		4 HIS P  92
HIS P  94
HIS P 155
PHE P  76
 ZN  P 304 (-3.3A)
ZN  P 304 (-3.3A)
ZN  P 304 (-3.3A)
None
 1.17A 5zrdB-1e4aP:
undetectable		 5zrdB-1e4aP:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hcy ARTHROPODAN
HEMOCYANIN

(Panulirus
interruptus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 HIS A 194
HIS A 198
HIS A 224
PHE A 380
 CU  A 665 (-3.0A)
CU  A 665 (-3.1A)
CU  A 665 (-3.5A)
None
 0.87A 5zrdB-1hcyA:
3.4		 5zrdB-1hcyA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hcy ARTHROPODAN
HEMOCYANIN

(Panulirus
interruptus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 HIS A 344
HIS A 348
HIS A 384
PHE A 220
 CU  A 666 (-3.1A)
CU  A 666 (-3.8A)
CU  A 666 (-3.4A)
None
 1.09A 5zrdB-1hcyA:
3.4		 5zrdB-1hcyA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js8 HEMOCYANIN

(Enteroctopus
dofleini) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		5 HIS A2543
CYH A2560
HIS A2562
HIS A2571
PHE A2698
 CUO  A 888 (-3.4A)
CUO  A 888 ( 3.8A)
CUO  A 888 (-3.4A)
CUO  A 888 (-3.3A)
None
 0.44A 5zrdB-1js8A:
4.5		 5zrdB-1js8A:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js8 HEMOCYANIN

(Enteroctopus
dofleini) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS A2671
HIS A2675
HIS A2702
PHE A2567
 CUO  A 888 (-3.4A)
CUO  A 888 (-3.3A)
CUO  A 888 (-3.3A)
CUO  A 888 (-4.8A)
 0.91A 5zrdB-1js8A:
4.5		 5zrdB-1js8A:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lla HEMOCYANIN (SUBUNIT
TYPE II)

(Limulus
polyphemus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 HIS A 173
HIS A 177
HIS A 204
PHE A 360
 CU  A 629 (-3.2A)
CU  A 629 (-3.2A)
CU  A 629 (-3.1A)
CU  A 630 ( 4.7A)
 0.69A 5zrdB-1llaA:
3.2		 5zrdB-1llaA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lla HEMOCYANIN (SUBUNIT
TYPE II)

(Limulus
polyphemus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 HIS A 177
HIS A 204
HIS A 173
PHE A  49
 CU  A 629 (-3.2A)
CU  A 629 (-3.1A)
CU  A 629 (-3.2A)
None
 1.22A 5zrdB-1llaA:
3.2		 5zrdB-1llaA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lla HEMOCYANIN (SUBUNIT
TYPE II)

(Limulus
polyphemus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 HIS A 324
HIS A 204
HIS A 177
PHE A  49
 CU  A 630 (-3.3A)
CU  A 629 (-3.1A)
CU  A 629 (-3.2A)
None
 1.10A 5zrdB-1llaA:
3.2		 5zrdB-1llaA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lla HEMOCYANIN (SUBUNIT
TYPE II)

(Limulus
polyphemus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 HIS A 324
HIS A 328
HIS A 364
PHE A 200
 CU  A 630 (-3.3A)
CU  A 630 (-3.2A)
CU  A 630 (-3.0A)
None
 0.99A 5zrdB-1llaA:
3.2		 5zrdB-1llaA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lnl HEMOCYANIN

(Rapana venosa) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		5 HIS A  41
CYH A  59
HIS A  61
HIS A  70
PHE A 208
 CU  A5001 (-2.9A)
CU  A5001 (-3.4A)
CU  A5001 (-3.6A)
CU  A5001 ( 3.1A)
None
 0.56A 5zrdB-1lnlA:
27.4		 5zrdB-1lnlA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lnl HEMOCYANIN

(Rapana venosa) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS A 181
HIS A 185
HIS A 212
PHE A  66
 CU  A5012 (-3.4A)
CU  A5012 (-3.2A)
CU  A5012 (-3.1A)
None
 0.98A 5zrdB-1lnlA:
27.4		 5zrdB-1lnlA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lnl HEMOCYANIN

(Rapana venosa) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS A 185
HIS A 181
HIS A  70
PHE A 208
 CU  A5012 (-3.2A)
CU  A5012 (-3.4A)
CU  A5001 ( 3.1A)
None
 1.23A 5zrdB-1lnlA:
27.4		 5zrdB-1lnlA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pq4 PERIPLASMIC BINDING
PROTEIN COMPONENT OF
AN ABC TYPE ZINC
UPTAKE TRANSPORTER

(Synechocystis
sp. PCC 6803) 		PF01297
(ZnuA) 		4 HIS A 243
HIS A 179
HIS A  83
PHE A 293
 ZN  A1002 (-3.2A)
ZN  A1002 (-3.3A)
ZN  A1002 (-3.1A)
None
 0.93A 5zrdB-1pq4A:
undetectable		 5zrdB-1pq4A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vzh DESULFOFERRODOXIN

(Desulfarculus
baarsii) 		PF01880
(Desulfoferrodox)
PF06397
(Desulfoferrod_N) 		4 HIS A  49
CYH A 116
HIS A  75
HIS A  69
 FE  A1129 ( 3.4A)
FE  A1129 (-2.7A)
FE  A1129 ( 3.4A)
FE  A1129 ( 3.4A)
 1.23A 5zrdB-1vzhA:
undetectable		 5zrdB-1vzhA:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vzh DESULFOFERRODOXIN

(Desulfarculus
baarsii) 		PF01880
(Desulfoferrodox)
PF06397
(Desulfoferrod_N) 		4 HIS A 119
CYH A 116
HIS A  75
HIS A  69
 FE  A1129 ( 3.2A)
FE  A1129 (-2.7A)
FE  A1129 ( 3.4A)
FE  A1129 ( 3.4A)
 1.23A 5zrdB-1vzhA:
undetectable		 5zrdB-1vzhA:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wx4 TYROSINASE

(Streptomyces
castaneoglobisporus) 		PF00264
(Tyrosinase) 		4 HIS A  38
HIS A  54
HIS A  63
PHE A 212
 CU  A 400 ( 3.3A)
CU  A 400 ( 3.3A)
CU  A 400 ( 3.5A)
PER  A 409 (-4.9A)
 0.36A 5zrdB-1wx4A:
3.7		 5zrdB-1wx4A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wx4 TYROSINASE

(Streptomyces
castaneoglobisporus) 		PF00264
(Tyrosinase) 		4 HIS A 190
HIS A 194
HIS A 216
PHE A  59
 CU  A 401 ( 3.2A)
CU  A 401 ( 3.2A)
CU  A 401 ( 3.4A)
None
 1.00A 5zrdB-1wx4A:
3.7		 5zrdB-1wx4A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y07 DESULFOFERRODOXIN
(RBO)

(Treponema
pallidum) 		PF01880
(Desulfoferrodox) 		4 HIS A  50
CYH A 119
HIS A  76
HIS A  70
 FE  A 130 (-3.4A)
FE  A 130 (-2.3A)
FE  A 130 (-3.5A)
FE  A 130 (-3.3A)
 1.22A 5zrdB-1y07A:
undetectable		 5zrdB-1y07A:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmh ELECTRON TRANSFER
FLAVOPROTEIN-UBIQUIN
ONE OXIDOREDUCTASE

(Sus scrofa) 		PF05187
(ETF_QO)
PF13450
(NAD_binding_8) 		4 HIS A 555
CYH A 553
HIS A 503
HIS A 496
 None
SF4  A 610 (-2.3A)
None
None
 0.97A 5zrdB-2gmhA:
undetectable		 5zrdB-2gmhA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hvb SUPEROXIDE REDUCTASE

(Pyrococcus
horikoshii) 		PF01880
(Desulfoferrodox) 		4 HIS A  25
CYH A 111
HIS A  56
HIS A  50
 FE  A 201 (-3.3A)
FE  A 201 (-2.2A)
FE  A 201 (-3.4A)
FE  A 201 (-3.5A)
 1.18A 5zrdB-2hvbA:
3.1		 5zrdB-2hvbA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hvb SUPEROXIDE REDUCTASE

(Pyrococcus
horikoshii) 		PF01880
(Desulfoferrodox) 		4 HIS A 114
CYH A 111
HIS A  56
HIS A  50
 FE  A 201 (-3.2A)
FE  A 201 (-2.2A)
FE  A 201 (-3.4A)
FE  A 201 (-3.5A)
 1.19A 5zrdB-2hvbA:
3.1		 5zrdB-2hvbA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3x POLYPHENOL OXIDASE,
CHLOROPLAST

(Vitis vinifera) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		4 HIS A  87
CYH A  91
HIS A 108
PHE A 268
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.6A)
C2O  A 340 (-3.3A)
C2O  A 340 ( 4.7A)
 1.17A 5zrdB-2p3xA:
3.6		 5zrdB-2p3xA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3x POLYPHENOL OXIDASE,
CHLOROPLAST

(Vitis vinifera) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		4 HIS A  87
HIS A 108
HIS A 117
PHE A 268
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.5A)
C2O  A 340 ( 4.7A)
 0.29A 5zrdB-2p3xA:
3.6		 5zrdB-2p3xA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3x POLYPHENOL OXIDASE,
CHLOROPLAST

(Vitis vinifera) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		4 HIS A 239
HIS A 243
HIS A 272
PHE A 113
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.1A)
None
 0.96A 5zrdB-2p3xA:
3.6		 5zrdB-2p3xA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9x POLYPHENOL OXIDASE

(Agaricus
bisporus) 		PF00264
(Tyrosinase) 		5 HIS A  61
CYH A  83
HIS A  85
HIS A  94
PHE A 292
 CU  A 400 (-3.2A)
CU  A 400 (-3.7A)
CU  A 400 (-3.3A)
CU  A 400 (-3.2A)
CU  A 401 ( 4.9A)
 0.28A 5zrdB-2y9xA:
34.3		 5zrdB-2y9xA:
26.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9x POLYPHENOL OXIDASE

(Agaricus
bisporus) 		PF00264
(Tyrosinase) 		4 HIS A 259
HIS A 263
HIS A 296
PHE A  90
 CU  A 401 (-3.2A)
0TR  A 410 ( 3.1A)
CU  A 401 (-3.2A)
None
 1.06A 5zrdB-2y9xA:
34.3		 5zrdB-2y9xA:
26.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dcp HISTIDINOL-PHOSPHATA
SE

(Listeria
monocytogenes) 		PF02811
(PHP)
PF13263
(PHP_C) 		4 HIS A 260
CYH A  12
HIS A  14
HIS A  40
 ZN  A 301 (-3.4A)
ZN  A 301 ( 3.8A)
ZN  A 301 (-3.5A)
ZN  A 301 (-3.5A)
 1.21A 5zrdB-3dcpA:
undetectable		 5zrdB-3dcpA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhs PHENOLOXIDASE
SUBUNIT 1

(Manduca sexta) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 HIS B 209
HIS B 213
HIS B 239
PHE B 402
 CU  B 686 (-3.1A)
CU  B 686 (-3.3A)
CU  B 686 (-3.1A)
CU  B   1 ( 4.8A)
 0.73A 5zrdB-3hhsB:
3.5		 5zrdB-3hhsB:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhs PHENOLOXIDASE
SUBUNIT 1

(Manduca sexta) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 HIS B 366
HIS B 370
HIS B 406
PHE B 235
 CU  B   1 (-3.3A)
CU  B   1 (-3.2A)
CU  B   1 (-3.1A)
None
 1.02A 5zrdB-3hhsB:
3.5		 5zrdB-3hhsB:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhs PHENOLOXIDASE
SUBUNIT 1

(Manduca sexta) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 HIS B 370
HIS B 406
HIS B 366
PHE B  85
 CU  B   1 (-3.2A)
CU  B   1 (-3.1A)
CU  B   1 (-3.3A)
None
 1.15A 5zrdB-3hhsB:
3.5		 5zrdB-3hhsB:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhs PHENOLOXIDASE
SUBUNIT 2

(Manduca sexta) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 HIS A 215
HIS A 219
HIS A 245
PHE A 404
 CU  A 696 (-3.2A)
CU  A 696 (-3.3A)
CU  A 696 (-3.2A)
CU  A 697 ( 4.9A)
 0.77A 5zrdB-3hhsA:
5.0		 5zrdB-3hhsA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhs PHENOLOXIDASE
SUBUNIT 2

(Manduca sexta) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 HIS A 368
HIS A 372
HIS A 408
PHE A 241
 CU  A 697 (-3.2A)
CU  A 697 (-3.2A)
CU  A 697 (-3.1A)
None
 1.04A 5zrdB-3hhsA:
5.0		 5zrdB-3hhsA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhs PHENOLOXIDASE
SUBUNIT 2

(Manduca sexta) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 HIS A 372
HIS A 408
HIS A 368
PHE A  88
 CU  A 697 (-3.2A)
CU  A 697 (-3.1A)
CU  A 697 (-3.2A)
None
 1.21A 5zrdB-3hhsA:
5.0		 5zrdB-3hhsA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qzb PUTATIVE SUPEROXIDE
REDUCTASE

(Thermotoga
maritima) 		PF01880
(Desulfoferrodox) 		4 HIS A  17
CYH A 115
HIS A  51
HIS A  45
 FE  A 132 (-3.4A)
FE  A 132 (-2.3A)
FE  A 132 (-3.4A)
FE  A 132 (-3.4A)
 1.21A 5zrdB-3qzbA:
2.7		 5zrdB-3qzbA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qzb PUTATIVE SUPEROXIDE
REDUCTASE

(Thermotoga
maritima) 		PF01880
(Desulfoferrodox) 		4 HIS A 118
CYH A 115
HIS A  51
HIS A  45
 FE  A 132 (-3.3A)
FE  A 132 (-2.3A)
FE  A 132 (-3.4A)
FE  A 132 (-3.4A)
 1.20A 5zrdB-3qzbA:
2.7		 5zrdB-3qzbA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6q TYROSINASE

(Aspergillus
oryzae) 		PF00264
(Tyrosinase) 		5 HIS A  67
CYH A  92
HIS A  94
HIS A 103
PHE A 368
 None
 0.76A 5zrdB-3w6qA:
24.2		 5zrdB-3w6qA:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6q TYROSINASE

(Aspergillus
oryzae) 		PF00264
(Tyrosinase) 		5 HIS A  94
CYH A  92
HIS A 103
HIS A  67
PHE A 513
 None
 1.18A 5zrdB-3w6qA:
24.2		 5zrdB-3w6qA:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6q TYROSINASE

(Aspergillus
oryzae) 		PF00264
(Tyrosinase) 		4 HIS A 103
CYH A  92
HIS A  67
HIS A  94
 None
 1.20A 5zrdB-3w6qA:
24.2		 5zrdB-3w6qA:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6q TYROSINASE

(Aspergillus
oryzae) 		PF00264
(Tyrosinase) 		4 HIS A 328
HIS A 332
HIS A 372
PHE A  99
 None
 1.04A 5zrdB-3w6qA:
24.2		 5zrdB-3w6qA:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wky PROPHENOLOXIDASE B

(Marsupenaeus
japonicus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 HIS A 199
HIS A 203
HIS A 226
PHE A 393
 CUO  A 708 (-3.3A)
CUO  A 708 (-3.5A)
CUO  A 708 (-3.3A)
CUO  A 708 (-4.5A)
 0.74A 5zrdB-3wkyA:
3.6		 5zrdB-3wkyA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wky PROPHENOLOXIDASE B

(Marsupenaeus
japonicus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 HIS A 203
HIS A 226
HIS A 199
PHE A  72
 CUO  A 708 (-3.5A)
CUO  A 708 (-3.3A)
CUO  A 708 (-3.3A)
CUO  A 708 (-4.6A)
 1.21A 5zrdB-3wkyA:
3.6		 5zrdB-3wkyA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wky PROPHENOLOXIDASE B

(Marsupenaeus
japonicus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 HIS A 357
HIS A 361
HIS A 397
PHE A 222
 CUO  A 708 (-3.3A)
CUO  A 708 (-3.2A)
CUO  A 708 (-3.4A)
None
 0.95A 5zrdB-3wkyA:
3.6		 5zrdB-3wkyA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		5 HIS A  42
CYH A  58
HIS A  60
HIS A  69
PHE A 206
 CUO  A9001 (-3.4A)
CUO  A9001 ( 4.2A)
CUO  A9001 (-3.1A)
CUO  A9001 (-3.1A)
CUO  A9001 (-4.6A)
 0.52A 5zrdB-4bedA:
2.7		 5zrdB-4bedA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		5 HIS A 462
CYH A 480
HIS A 482
HIS A 491
PHE A 629
 CUO  A9002 (-3.2A)
CUO  A9002 (-3.2A)
CUO  A9002 (-3.4A)
CUO  A9002 (-3.4A)
CUO  A9002 (-4.3A)
 0.86A 5zrdB-4bedA:
2.7		 5zrdB-4bedA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS A 482
CYH A 480
HIS A 491
HIS A 462
 CUO  A9002 (-3.4A)
CUO  A9002 (-3.2A)
CUO  A9002 (-3.4A)
CUO  A9002 (-3.2A)
 1.00A 5zrdB-4bedA:
2.7		 5zrdB-4bedA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS A 491
CYH A 480
HIS A 462
HIS A 482
 CUO  A9002 (-3.4A)
CUO  A9002 (-3.2A)
CUO  A9002 (-3.2A)
CUO  A9002 (-3.4A)
 1.15A 5zrdB-4bedA:
2.7		 5zrdB-4bedA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		5 HIS A 876
CYH A 894
HIS A 896
HIS A 905
PHE A1042
 CUO  A9003 (-3.3A)
CUO  A9003 (-3.1A)
CUO  A9003 (-3.4A)
CUO  A9003 (-3.5A)
CUO  A9003 ( 4.9A)
 0.86A 5zrdB-4bedA:
2.7		 5zrdB-4bedA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS A 896
CYH A 894
HIS A 905
HIS A 876
 CUO  A9003 (-3.4A)
CUO  A9003 (-3.1A)
CUO  A9003 (-3.5A)
CUO  A9003 (-3.3A)
 0.99A 5zrdB-4bedA:
2.7		 5zrdB-4bedA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS A 905
CYH A 894
HIS A 876
HIS A 896
 CUO  A9003 (-3.5A)
CUO  A9003 (-3.1A)
CUO  A9003 (-3.3A)
CUO  A9003 (-3.4A)
 1.22A 5zrdB-4bedA:
2.7		 5zrdB-4bedA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		5 HIS A1293
CYH A1309
HIS A1311
HIS A1320
PHE A1451
 CUO  A9004 (-3.2A)
CUO  A9004 ( 3.9A)
CUO  A9004 (-3.4A)
CUO  A9004 (-3.5A)
CUO  A9004 (-4.5A)
 0.80A 5zrdB-4bedA:
2.7		 5zrdB-4bedA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS A1320
CYH A1309
HIS A1293
HIS A1311
 CUO  A9004 (-3.5A)
CUO  A9004 ( 3.9A)
CUO  A9004 (-3.2A)
CUO  A9004 (-3.4A)
 1.07A 5zrdB-4bedA:
2.7		 5zrdB-4bedA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS B1705
HIS B1725
HIS B1734
PHE B1874
 CUO  B9005 (-3.2A)
CUO  B9005 (-3.1A)
CUO  B9005 (-3.4A)
CUO  B9005 (-4.4A)
 0.31A 5zrdB-4bedB:
27.9		 5zrdB-4bedB:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS B1847
HIS B1851
HIS B1878
PHE B1730
 CUO  B9005 (-3.2A)
CUO  B9005 (-3.2A)
CUO  B9005 (-3.3A)
CUO  B9005 ( 4.9A)
 1.22A 5zrdB-4bedB:
27.9		 5zrdB-4bedB:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		5 HIS B2122
CYH B2139
HIS B2141
HIS B2150
PHE B2287
 CUO  B9006 (-3.2A)
CUO  B9006 (-3.6A)
CUO  B9006 (-3.1A)
CUO  B9006 (-3.3A)
CUO  B9006 (-4.7A)
 1.02A 5zrdB-4bedB:
27.9		 5zrdB-4bedB:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS B2141
CYH B2139
HIS B2150
HIS B2122
 CUO  B9006 (-3.1A)
CUO  B9006 (-3.6A)
CUO  B9006 (-3.3A)
CUO  B9006 (-3.2A)
 0.92A 5zrdB-4bedB:
27.9		 5zrdB-4bedB:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS B2542
CYH B2559
HIS B2570
PHE B2697
 CUO  B9007 (-3.3A)
CUO  B9007 ( 3.7A)
CUO  B9007 (-3.3A)
CUO  B9007 (-4.7A)
 0.88A 5zrdB-4bedB:
27.9		 5zrdB-4bedB:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS B2542
HIS B2561
HIS B2570
PHE B2697
 CUO  B9007 (-3.3A)
CUO  B9007 (-3.3A)
CUO  B9007 (-3.3A)
CUO  B9007 (-4.7A)
 0.39A 5zrdB-4bedB:
27.9		 5zrdB-4bedB:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS B2570
CYH B2559
HIS B2542
HIS B2561
 CUO  B9007 (-3.3A)
CUO  B9007 ( 3.7A)
CUO  B9007 (-3.3A)
CUO  B9007 (-3.3A)
 1.05A 5zrdB-4bedB:
27.9		 5zrdB-4bedB:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS B2670
HIS B2674
HIS B2701
PHE B2566
 CUO  B9007 (-3.4A)
CUO  B9007 (-3.4A)
CUO  B9007 (-3.1A)
CUO  B9007 ( 4.9A)
 1.11A 5zrdB-4bedB:
27.9		 5zrdB-4bedB:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		5 HIS B2946
CYH B2963
HIS B2965
HIS B2974
PHE B3102
 CUO  B9008 (-3.1A)
CUO  B9008 (-3.0A)
CUO  B9008 (-3.2A)
CUO  B9008 (-2.9A)
CUO  B9008 (-4.7A)
 0.73A 5zrdB-4bedB:
27.9		 5zrdB-4bedB:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS B2965
HIS B2946
HIS B3106
PHE B2970
 CUO  B9008 (-3.2A)
CUO  B9008 (-3.1A)
CUO  B9008 (-3.3A)
None
 1.11A 5zrdB-4bedB:
27.9		 5zrdB-4bedB:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS B3075
HIS B3079
HIS B3106
PHE B2970
 CUO  B9008 (-2.8A)
CUO  B9008 (-3.5A)
CUO  B9008 (-3.3A)
None
 1.14A 5zrdB-4bedB:
27.9		 5zrdB-4bedB:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4brj DESULFOFERRODOXIN,
FERROUS IRON-BINDING
REGION

(Ignicoccus
hospitalis) 		PF01880
(Desulfoferrodox) 		4 HIS A 112
CYH A 109
HIS A  56
HIS A  50
 FE  A1125 (-3.3A)
FE  A1125 (-2.6A)
FE  A1125 (-3.5A)
FE  A1125 (-3.2A)
 1.14A 5zrdB-4brjA:
undetectable		 5zrdB-4brjA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c4b SUPEROXIDE REDUCTASE

(Archaeoglobus
fulgidus) 		PF01880
(Desulfoferrodox) 		4 HIS A 113
CYH A 110
HIS A  46
HIS A  40
 FE2  A1001 (-3.2A)
FE2  A1001 (-2.4A)
FE2  A1001 (-3.4A)
FE2  A1001 (-3.4A)
 1.17A 5zrdB-4c4bA:
undetectable		 5zrdB-4c4bA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7p SUPEROXIDE REDUCTASE

(Giardia
intestinalis) 		PF01880
(Desulfoferrodox) 		4 HIS A 102
CYH A  99
HIS A  46
HIS A  40
 FE  A 201 (-3.4A)
FE  A 201 (-2.3A)
FE  A 201 (-3.3A)
FE  A 201 (-3.4A)
 1.20A 5zrdB-4d7pA:
3.4		 5zrdB-4d7pA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i7h PEROXIDE STRESS
SENSING REGULATOR

(Streptococcus
pyogenes) 		PF01475
(FUR) 		4 HIS A  19
HIS A   4
HIS A  97
PHE A  78
 NI  A 201 (-3.5A)
NI  A 201 (-3.6A)
NI  A 201 (-3.6A)
None
 0.97A 5zrdB-4i7hA:
undetectable		 5zrdB-4i7hA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3q CATECHOL OXIDASE

(Aspergillus
oryzae) 		PF00264
(Tyrosinase) 		4 HIS A 102
HIS A 110
HIS A 119
PHE A 308
 CU  A1001 (-3.2A)
CU  A1001 (-3.3A)
CU  A1001 (-3.2A)
CU  A1002 ( 4.9A)
 0.44A 5zrdB-4j3qA:
3.9		 5zrdB-4j3qA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3q CATECHOL OXIDASE

(Aspergillus
oryzae) 		PF00264
(Tyrosinase) 		4 HIS A 284
HIS A 288
HIS A 312
PHE A 115
 CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
None
 1.06A 5zrdB-4j3qA:
3.9		 5zrdB-4j3qA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oua LATENT FORM OF PPO4
TYROSINASE

(Agaricus
bisporus) 		PF00264
(Tyrosinase) 		5 HIS B  57
CYH B  80
HIS B  82
HIS B  91
PHE B 279
 CU1  B 601 (-3.1A)
CU1  B 601 (-3.5A)
CU1  B 601 (-3.1A)
CU1  B 601 (-3.2A)
CU1  B 602 (-4.5A)
 0.39A 5zrdB-4ouaB:
34.4		 5zrdB-4ouaB:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oua LATENT FORM OF PPO4
TYROSINASE

(Agaricus
bisporus) 		PF00264
(Tyrosinase) 		4 HIS B 251
HIS B 255
HIS B 283
PHE B  87
 CU1  B 602 (-3.2A)
CU1  B 602 (-3.1A)
CU1  B 602 (-3.0A)
None
 1.04A 5zrdB-4ouaB:
34.4		 5zrdB-4ouaB:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE

(Agaricus
bisporus) 		PF00264
(Tyrosinase) 		5 HIS A  57
CYH A  80
HIS A  82
HIS A  91
PHE A 279
 CU1  A 401 (-3.2A)
CU1  A 401 (-3.7A)
CU1  A 401 (-3.3A)
CU1  A 401 (-3.3A)
CU1  A 402 (-4.8A)
 0.36A 5zrdB-4ouaA:
33.9		 5zrdB-4ouaA:
27.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE

(Agaricus
bisporus) 		PF00264
(Tyrosinase) 		4 HIS A 251
HIS A 255
HIS A 283
PHE A  87
 CU1  A 402 (-3.0A)
CU1  A 402 (-3.1A)
CU1  A 402 (-2.9A)
None
 0.99A 5zrdB-4ouaA:
33.9		 5zrdB-4ouaA:
27.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzw AGAP004976-PA

(Anopheles
gambiae) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 HIS A 223
HIS A 227
HIS A 252
PHE A 415
 CU  A 801 (-3.0A)
CU  A 801 (-3.2A)
CU  A 801 (-3.2A)
CU  A 802 ( 4.9A)
 0.76A 5zrdB-4yzwA:
6.7		 5zrdB-4yzwA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzw AGAP004976-PA

(Anopheles
gambiae) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 HIS A 379
HIS A 383
HIS A 419
PHE A 248
 CU  A 802 (-3.2A)
CU  A 802 (-3.2A)
CU  A 802 (-3.1A)
None
 1.04A 5zrdB-4yzwA:
6.7		 5zrdB-4yzwA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzw AGAP004976-PA

(Anopheles
gambiae) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 HIS A 383
HIS A 419
HIS A 379
PHE A  99
 CU  A 802 (-3.2A)
CU  A 802 (-3.1A)
CU  A 802 (-3.2A)
None
 1.24A 5zrdB-4yzwA:
6.7		 5zrdB-4yzwA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0z AURONE SYNTHASE

(Coreopsis
grandiflora) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		4 HIS A  93
CYH A  97
HIS A 116
PHE A 282
 CU  A 700 (-3.1A)
CU  A 700 (-3.5A)
CU  A 700 (-3.2A)
None
 1.11A 5zrdB-4z0zA:
3.1		 5zrdB-4z0zA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0z AURONE SYNTHASE

(Coreopsis
grandiflora) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		4 HIS A  93
HIS A 116
HIS A 125
PHE A 282
 CU  A 700 (-3.1A)
CU  A 700 (-3.2A)
CU  A 700 (-3.2A)
None
 0.40A 5zrdB-4z0zA:
3.1		 5zrdB-4z0zA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z11 AURONE SYNTHASE

(Coreopsis
grandiflora) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL)
PF12143
(PPO1_KFDV) 		4 HIS A  93
CYH A  97
HIS A 116
PHE A 282
 CU  A 700 (-3.2A)
CU  A 700 (-3.5A)
CU  A 700 (-3.2A)
None
 1.12A 5zrdB-4z11A:
19.7		 5zrdB-4z11A:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z11 AURONE SYNTHASE

(Coreopsis
grandiflora) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL)
PF12143
(PPO1_KFDV) 		4 HIS A  93
HIS A 116
HIS A 125
PHE A 282
 CU  A 700 (-3.2A)
CU  A 700 (-3.2A)
CU  A 700 (-3.2A)
None
 0.29A 5zrdB-4z11A:
19.7		 5zrdB-4z11A:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z11 AURONE SYNTHASE

(Coreopsis
grandiflora) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL)
PF12143
(PPO1_KFDV) 		4 HIS A 252
HIS A 256
HIS A 286
PHE A 121
 CU  A 701 (-3.1A)
CU  A 701 (-3.1A)
CU  A 701 (-3.1A)
None
 0.97A 5zrdB-4z11A:
19.7		 5zrdB-4z11A:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ce9 POLYPHENOL OXIDASE

(Juglans regia) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		4 HIS A  87
CYH A  91
HIS A 108
PHE A 269
 CU  A 402 ( 3.2A)
CU  A 402 (-3.5A)
CU  A 402 ( 3.2A)
CU  A 401 ( 4.9A)
 1.06A 5zrdB-5ce9A:
3.6		 5zrdB-5ce9A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ce9 POLYPHENOL OXIDASE

(Juglans regia) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		4 HIS A  87
HIS A 108
HIS A 117
PHE A 269
 CU  A 402 ( 3.2A)
CU  A 402 ( 3.2A)
CU  A 402 ( 3.2A)
CU  A 401 ( 4.9A)
 0.28A 5zrdB-5ce9A:
3.6		 5zrdB-5ce9A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ce9 POLYPHENOL OXIDASE

(Juglans regia) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		4 HIS A 239
HIS A 243
HIS A 273
PHE A 113
 CU  A 401 ( 3.2A)
CU  A 401 ( 3.2A)
CU  A 401 ( 3.2A)
None
 0.96A 5zrdB-5ce9A:
3.6		 5zrdB-5ce9A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3a TYROSINASE

(Bacillus
megaterium) 		PF00264
(Tyrosinase) 		4 HIS A  42
HIS A  60
HIS A  69
PHE A 227
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
ZN  A 302 ( 4.9A)
ZN  A 302 ( 4.7A)
 0.34A 5zrdB-5i3aA:
4.0		 5zrdB-5i3aA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3a TYROSINASE

(Bacillus
megaterium) 		PF00264
(Tyrosinase) 		4 HIS A 204
HIS A 208
HIS A 231
PHE A  65
 ZN  A 302 ( 3.4A)
HQE  A 303 ( 3.0A)
ZN  A 302 (-3.1A)
None
 0.97A 5zrdB-5i3aA:
4.0		 5zrdB-5i3aA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE

(Homo sapiens) 		PF00264
(Tyrosinase) 		4 HIS A 192
HIS A 215
HIS A 224
PHE A 400
 ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
ZN  A 512 (-3.5A)
ZN  A 511 ( 4.7A)
 0.37A 5zrdB-5m8tA:
3.0		 5zrdB-5m8tA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE

(Homo sapiens) 		PF00264
(Tyrosinase) 		4 HIS A 377
HIS A 381
HIS A 404
PHE A 220
 ZN  A 511 ( 3.2A)
ZN  A 511 ( 3.3A)
ZN  A 511 (-3.1A)
None
 1.01A 5zrdB-5m8tA:
3.0		 5zrdB-5m8tA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5or4 CATECHOL OXIDASE

(Aspergillus
oryzae) 		no annotation 4 HIS A 102
HIS A 110
HIS A 119
PHE A 308
 CU  A2001 (-3.3A)
CU  A2001 (-3.3A)
CU  A2001 (-3.3A)
None
 0.53A 5zrdB-5or4A:
20.5		 5zrdB-5or4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5or4 CATECHOL OXIDASE

(Aspergillus
oryzae) 		no annotation 4 HIS A 284
HIS A 288
HIS A 312
PHE A 115
 CU  A2002 (-3.2A)
CU  A2002 (-3.2A)
CU  A2002 (-3.1A)
None
 0.98A 5zrdB-5or4A:
20.5		 5zrdB-5or4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9

(Homo sapiens) 		PF00413
(Peptidase_M10)
PF01471
(PG_binding_1) 		4 HIS A 190
HIS A 175
HIS A 203
PHE A 192
 ZN  A 502 (-3.2A)
ZN  A 502 (-3.2A)
ZN  A 502 (-3.1A)
None
 1.22A 5zrdB-5th6A:
undetectable		 5zrdB-5th6A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vn5 2,2',3-TRIHYDROXY-3'
-METHOXY-5,5'-DICARB
OXYBIPHENYL
META-CLEAVAGE
COMPOUND HYDROLASE

(Sphingobium sp.
SYK-6) 		PF04909
(Amidohydro_2) 		4 HIS A 179
HIS A   6
HIS A   8
PHE A 194
 ZN  A 400 (-3.2A)
ZN  A 400 (-3.3A)
ZN  A 400 (-3.2A)
None
 1.21A 5zrdB-5vn5A:
undetectable		 5zrdB-5vn5A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eys -

(-) 		no annotation 4 HIS B 216
HIS B 220
HIS B 271
PHE B 428
 None
 0.89A 5zrdB-6eysB:
2.3		 5zrdB-6eysB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eys -

(-) 		no annotation 4 HIS B 375
HIS B 379
HIS B 432
PHE B 267
 None
 1.10A 5zrdB-6eysB:
2.3		 5zrdB-6eysB:
undetectable