SIMILAR PATTERNS OF AMINO ACIDS FOR 5ZRD_A_CUA607

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b66 6-PYRUVOYL
TETRAHYDROPTERIN
SYNTHASE

(Rattus rattus) 		PF01242
(PTPS) 		3 HIS A  23
HIS A  50
HIS A  48
 ZN  A 401 ( 3.4A)
ZN  A 401 ( 3.4A)
ZN  A 401 ( 3.4A)
 0.59A 5zrdA-1b66A:
undetectable		 5zrdA-1b66A:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b66 6-PYRUVOYL
TETRAHYDROPTERIN
SYNTHASE

(Rattus rattus) 		PF01242
(PTPS) 		3 HIS A  48
HIS A  23
HIS A  50
 ZN  A 401 ( 3.4A)
ZN  A 401 ( 3.4A)
ZN  A 401 ( 3.4A)
 0.57A 5zrdA-1b66A:
undetectable		 5zrdA-1b66A:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bt2 PROTEIN (CATECHOL
OXIDASE)

(Ipomoea batatas) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		3 HIS A 240
HIS A 244
HIS A 274
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
 0.24A 5zrdA-1bt2A:
3.3		 5zrdA-1bt2A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hcy ARTHROPODAN
HEMOCYANIN

(Panulirus
interruptus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 HIS A 344
HIS A 348
HIS A 384
 CU  A 666 (-3.1A)
CU  A 666 (-3.8A)
CU  A 666 (-3.4A)
 0.54A 5zrdA-1hcyA:
5.6		 5zrdA-1hcyA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1joe AUTOINDUCER-2
PRODUCTION PROTEIN

(Haemophilus
influenzae) 		PF02664
(LuxS) 		3 HIS A  54
HIS A 134
HIS A  58
 ZN  A 205 (-3.3A)
None
ZN  A 205 (-3.4A)
 0.50A 5zrdA-1joeA:
undetectable		 5zrdA-1joeA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js8 HEMOCYANIN

(Enteroctopus
dofleini) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		3 HIS A2671
HIS A2675
HIS A2702
 CUO  A 888 (-3.4A)
CUO  A 888 (-3.3A)
CUO  A 888 (-3.3A)
 0.19A 5zrdA-1js8A:
27.6		 5zrdA-1js8A:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1juh QUERCETIN
2,3-DIOXYGENASE

(Aspergillus
japonicus) 		no annotation 3 HIS A  66
HIS A 112
HIS A  68
 CU  A 401 ( 3.3A)
CU  A 401 (-3.2A)
CU  A 401 (-3.2A)
 0.43A 5zrdA-1juhA:
undetectable		 5zrdA-1juhA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lla HEMOCYANIN (SUBUNIT
TYPE II)

(Limulus
polyphemus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 HIS A 324
HIS A 328
HIS A 364
 CU  A 630 (-3.3A)
CU  A 630 (-3.2A)
CU  A 630 (-3.0A)
 0.28A 5zrdA-1llaA:
5.3		 5zrdA-1llaA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lnl HEMOCYANIN

(Rapana venosa) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		3 HIS A 181
HIS A 185
HIS A 212
 CU  A5012 (-3.4A)
CU  A5012 (-3.2A)
CU  A5012 (-3.1A)
 0.59A 5zrdA-1lnlA:
26.8		 5zrdA-1lnlA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o4t PUTATIVE OXALATE
DECARBOXYLASE

(Thermotoga
maritima) 		PF07883
(Cupin_2) 		3 HIS A  61
HIS A 102
HIS A  63
 MN  A 300 ( 3.3A)
MN  A 300 ( 3.4A)
MN  A 300 ( 3.2A)
 0.58A 5zrdA-1o4tA:
undetectable		 5zrdA-1o4tA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tq5 PROTEIN YHHW

(Escherichia
coli) 		PF02678
(Pirin) 		3 HIS A 101
HIS A  59
HIS A  57
 CD  A1000 (-3.8A)
CD  A1000 (-3.4A)
CD  A1000 (-3.7A)
 0.56A 5zrdA-1tq5A:
undetectable		 5zrdA-1tq5A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txl METAL-BINDING
PROTEIN YODA

(Escherichia
coli) 		PF09223
(ZinT) 		3 HIS A 177
HIS A 175
HIS A 166
 ZN  A 216 (-3.1A)
ZN  A 216 (-3.6A)
ZN  A 216 (-3.3A)
 0.48A 5zrdA-1txlA:
undetectable		 5zrdA-1txlA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wx4 TYROSINASE

(Streptomyces
castaneoglobisporus) 		PF00264
(Tyrosinase) 		3 HIS A 190
HIS A 194
HIS A 216
 CU  A 401 ( 3.2A)
CU  A 401 ( 3.2A)
CU  A 401 ( 3.4A)
 0.09A 5zrdA-1wx4A:
3.1		 5zrdA-1wx4A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y13 6-PYRUVOYL
TETRAHYDROPTERIN
SYNTHASE

(Plasmodium
falciparum) 		PF01242
(PTPS) 		3 HIS A  29
HIS A  43
HIS A  41
 ZN  A 174 ( 3.5A)
ZN  A 174 ( 3.4A)
ZN  A 174 ( 3.3A)
 0.61A 5zrdA-1y13A:
undetectable		 5zrdA-1y13A:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y13 6-PYRUVOYL
TETRAHYDROPTERIN
SYNTHASE

(Plasmodium
falciparum) 		PF01242
(PTPS) 		3 HIS A  41
HIS A  29
HIS A  43
 ZN  A 174 ( 3.3A)
ZN  A 174 ( 3.5A)
ZN  A 174 ( 3.4A)
 0.60A 5zrdA-1y13A:
undetectable		 5zrdA-1y13A:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y3t HYPOTHETICAL PROTEIN
YXAG

(Bacillus
subtilis) 		PF07883
(Cupin_2) 		3 HIS A 234
HIS A 275
HIS A 236
 FE  A 402 (-3.3A)
FE  A 402 (-3.4A)
FE  A 402 (-3.4A)
 0.56A 5zrdA-1y3tA:
undetectable		 5zrdA-1y3tA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a0s 6-PYRUVOYL
TETRAHYDROPTERIN
SYNTHASE

(Plasmodium
vivax) 		PF01242
(PTPS) 		3 HIS A  48
HIS A  36
HIS A  50
 ZN  A 281 (-3.3A)
ZN  A 281 ( 3.5A)
ZN  A 281 (-3.3A)
 0.57A 5zrdA-2a0sA:
undetectable		 5zrdA-2a0sA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ete OXALATE OXIDASE 1

(Hordeum vulgare) 		PF00190
(Cupin_1) 		3 HIS A  88
HIS A 137
HIS A  90
 MN  A 202 ( 3.4A)
MN  A 202 (-3.3A)
MN  A 202 ( 3.2A)
 0.53A 5zrdA-2eteA:
undetectable		 5zrdA-2eteA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqp HYPOTHETICAL PROTEIN
BP2299

(Bordetella
pertussis) 		PF07883
(Cupin_2) 		3 HIS A  33
HIS A  76
HIS A  35
 ZN  A 100 (-3.2A)
ZN  A 100 ( 3.5A)
ZN  A 100 (-3.2A)
 0.45A 5zrdA-2fqpA:
undetectable		 5zrdA-2fqpA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g64 PUTATIVE 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE

(Caenorhabditis
elegans) 		PF01242
(PTPS) 		3 HIS A  19
HIS A  46
HIS A  44
 ZN  A2001 (-3.3A)
ZN  A2001 (-3.3A)
ZN  A2001 ( 3.3A)
 0.60A 5zrdA-2g64A:
undetectable		 5zrdA-2g64A:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g64 PUTATIVE 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE

(Caenorhabditis
elegans) 		PF01242
(PTPS) 		3 HIS A  44
HIS A  19
HIS A  46
 ZN  A2001 ( 3.3A)
ZN  A2001 (-3.3A)
ZN  A2001 (-3.3A)
 0.55A 5zrdA-2g64A:
undetectable		 5zrdA-2g64A:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8q HYPOTHETICAL PROTEIN

(Paraburkholderia
xenovorans) 		PF07883
(Cupin_2) 		3 HIS A  58
HIS A 100
HIS A  60
 NI  A 300 ( 3.3A)
NI  A 300 (-3.3A)
NI  A 300 (-3.3A)
 0.49A 5zrdA-2o8qA:
undetectable		 5zrdA-2o8qA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oba PROBABLE 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE

(Pseudomonas
aeruginosa) 		PF01242
(PTPS) 		3 HIS A  13
HIS A  30
HIS A  28
 ZN  A 200 (-3.6A)
ZN  A 200 (-3.4A)
ZN  A 200 (-3.6A)
 0.61A 5zrdA-2obaA:
undetectable		 5zrdA-2obaA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oba PROBABLE 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE

(Pseudomonas
aeruginosa) 		PF01242
(PTPS) 		3 HIS A  28
HIS A  13
HIS A  30
 ZN  A 200 (-3.6A)
ZN  A 200 (-3.6A)
ZN  A 200 (-3.4A)
 0.55A 5zrdA-2obaA:
undetectable		 5zrdA-2obaA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3x POLYPHENOL OXIDASE,
CHLOROPLAST

(Vitis vinifera) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		3 HIS A 239
HIS A 243
HIS A 272
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.1A)
 0.14A 5zrdA-2p3xA:
3.0		 5zrdA-2p3xA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2paj PUTATIVE
CYTOSINE/GUANINE
DEAMINASE

(unidentified) 		PF01979
(Amidohydro_1) 		3 HIS A 248
HIS A 285
HIS A  76
 ZN  A 493 (-3.2A)
ZN  A 493 (-3.5A)
ZN  A 493 (-3.5A)
 0.53A 5zrdA-2pajA:
undetectable		 5zrdA-2pajA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rg4 UNCHARACTERIZED
PROTEIN

(Oceanicola
granulosus) 		PF13759
(2OG-FeII_Oxy_5) 		3 HIS A 119
HIS A 187
HIS A 121
 FE  A 217 (-3.1A)
FE  A 217 (-3.4A)
FE  A 217 (-3.4A)
 0.58A 5zrdA-2rg4A:
undetectable		 5zrdA-2rg4A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vqa SLL1358 PROTEIN

(Synechocystis
sp. PCC 6803) 		PF00190
(Cupin_1) 		3 HIS A 283
HIS A 329
HIS A 285
 MN  A1006 ( 3.4A)
MN  A1006 (-3.5A)
MN  A1006 ( 3.5A)
 0.46A 5zrdA-2vqaA:
undetectable		 5zrdA-2vqaA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xla SLL1785 PROTEIN

(Synechocystis
sp. PCC 6803) 		no annotation 3 HIS A 117
HIS A 178
HIS A 119
 CU  A1298 (-3.3A)
CU  A1298 (-3.4A)
CU  A1298 (-3.2A)
 0.40A 5zrdA-2xlaA:
undetectable		 5zrdA-2xlaA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y0o PROBABLE D-LYXOSE
KETOL-ISOMERASE

(Bacillus
subtilis) 		no annotation 3 HIS A  69
HIS A 137
HIS A  71
 ZN  A1173 (-3.6A)
ZN  A1173 (-3.4A)
ZN  A1173 (-3.4A)
 0.44A 5zrdA-2y0oA:
undetectable		 5zrdA-2y0oA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9x POLYPHENOL OXIDASE

(Agaricus
bisporus) 		PF00264
(Tyrosinase) 		3 HIS A 259
HIS A 263
HIS A 296
 CU  A 401 (-3.2A)
0TR  A 410 ( 3.1A)
CU  A 401 (-3.2A)
 0.24A 5zrdA-2y9xA:
12.2		 5zrdA-2y9xA:
26.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bvc UNCHARACTERIZED
PROTEIN ISM_01780

(Roseovarius
nubinhibens) 		PF13759
(2OG-FeII_Oxy_5) 		3 HIS A 119
HIS A 187
HIS A 121
 NI  A 304 (-3.6A)
NI  A 304 (-3.5A)
NI  A 304 (-3.6A)
 0.46A 5zrdA-3bvcA:
undetectable		 5zrdA-3bvcA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d82 CUPIN 2, CONSERVED
BARREL DOMAIN
PROTEIN

(Shewanella
frigidimarina) 		PF07883
(Cupin_2) 		3 HIS A  44
HIS A  85
HIS A  46
 NI  A 500 ( 3.5A)
NI  A 500 (-3.7A)
NI  A 500 ( 3.6A)
 0.37A 5zrdA-3d82A:
undetectable		 5zrdA-3d82A:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fms TRANSCRIPTIONAL
REGULATOR, GNTR
FAMILY

(Thermotoga
maritima) 		PF00392
(GntR)
PF07729
(FCD) 		3 HIS A 174
HIS A 134
HIS A 196
 NI  A 301 (-3.3A)
NI  A 301 ( 3.3A)
NI  A 301 ( 3.3A)
 0.61A 5zrdA-3fmsA:
undetectable		 5zrdA-3fmsA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h8u UNCHARACTERIZED
CONSERVED PROTEIN
WITH DOUBLE-STRANDED
BETA-HELIX DOMAIN

(Klebsiella
pneumoniae) 		PF07883
(Cupin_2) 		3 HIS A  54
HIS A  96
HIS A  56
 None
 0.46A 5zrdA-3h8uA:
undetectable		 5zrdA-3h8uA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN

(Geobacter
sulfurreducens) 		PF08668
(HDOD) 		3 HIS A 217
HIS A 216
HIS A 192
 FE  A 305 (-3.3A)
FE  A 305 (-3.4A)
FE  A 305 (-3.5A)
 0.52A 5zrdA-3hc1A:
undetectable		 5zrdA-3hc1A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhs PHENOLOXIDASE
SUBUNIT 1

(Manduca sexta) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 HIS B 366
HIS B 370
HIS B 406
 CU  B   1 (-3.3A)
CU  B   1 (-3.2A)
CU  B   1 (-3.1A)
 0.23A 5zrdA-3hhsB:
5.6		 5zrdA-3hhsB:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhs PHENOLOXIDASE
SUBUNIT 2

(Manduca sexta) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 HIS A 368
HIS A 372
HIS A 408
 CU  A 697 (-3.2A)
CU  A 697 (-3.2A)
CU  A 697 (-3.1A)
 0.16A 5zrdA-3hhsA:
3.6		 5zrdA-3hhsA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i2b 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE

(Homo sapiens) 		PF01242
(PTPS) 		3 HIS A  24
HIS A  51
HIS A  49
 NI  A 146 (-3.1A)
NI  A 146 (-3.3A)
NI  A 146 (-3.1A)
 0.61A 5zrdA-3i2bA:
undetectable		 5zrdA-3i2bA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i2b 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE

(Homo sapiens) 		PF01242
(PTPS) 		3 HIS A  49
HIS A  24
HIS A  51
 NI  A 146 (-3.1A)
NI  A 146 (-3.1A)
NI  A 146 (-3.3A)
 0.53A 5zrdA-3i2bA:
undetectable		 5zrdA-3i2bA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i7d SUGAR PHOSPHATE
ISOMERASE

(Ruegeria
pomeroyi) 		PF07883
(Cupin_2) 		3 HIS A  59
HIS A 102
HIS A  61
 CAC  A 164 (-3.5A)
ACT  A 165 (-3.7A)
CAC  A 164 (-4.4A)
 0.55A 5zrdA-3i7dA:
undetectable		 5zrdA-3i7dA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jyg UNCHARACTERIZED
PROTEIN

(Wolinella
succinogenes) 		PF01242
(PTPS) 		3 HIS A  15
HIS A  40
HIS A  38
 ZN  A 200 (-3.5A)
ZN  A 200 (-3.4A)
ZN  A 200 (-3.3A)
 0.59A 5zrdA-3jygA:
undetectable		 5zrdA-3jygA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jyg UNCHARACTERIZED
PROTEIN

(Wolinella
succinogenes) 		PF01242
(PTPS) 		3 HIS A  38
HIS A  15
HIS A  40
 ZN  A 200 (-3.3A)
ZN  A 200 (-3.5A)
ZN  A 200 (-3.4A)
 0.60A 5zrdA-3jygA:
undetectable		 5zrdA-3jygA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kmh D-LYXOSE ISOMERASE

(Escherichia
coli) 		PF07385
(Lyx_isomer) 		3 HIS A 103
HIS A 171
HIS A 105
 MN  A1001 (-3.6A)
MN  A1001 (-3.3A)
MN  A1001 (-3.2A)
 0.43A 5zrdA-3kmhA:
undetectable		 5zrdA-3kmhA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lag UNCHARACTERIZED
PROTEIN RPA4178

(Rhodopseudomonas
palustris) 		PF07883
(Cupin_2) 		3 HIS A  32
HIS A  76
HIS A  34
 NI  A  98 ( 3.3A)
NI  A  98 ( 3.4A)
NI  A  98 ( 3.2A)
 0.47A 5zrdA-3lagA:
undetectable		 5zrdA-3lagA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qna 6-CARBOXY-5,6,7,8-TE
TRAHYDROPTERIN
SYNTHASE

(Escherichia
coli) 		PF01242
(PTPS) 		3 HIS A  15
HIS A  32
HIS A  30
 ZN  A 122 ( 3.3A)
ZN  A 122 ( 3.2A)
ZN  A 122 ( 3.2A)
 0.60A 5zrdA-3qnaA:
undetectable		 5zrdA-3qnaA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qna 6-CARBOXY-5,6,7,8-TE
TRAHYDROPTERIN
SYNTHASE

(Escherichia
coli) 		PF01242
(PTPS) 		3 HIS A  30
HIS A  15
HIS A  32
 ZN  A 122 ( 3.2A)
ZN  A 122 ( 3.3A)
ZN  A 122 ( 3.2A)
 0.58A 5zrdA-3qnaA:
undetectable		 5zrdA-3qnaA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rzv STAM-BINDING PROTEIN

(Homo sapiens) 		PF01398
(JAB) 		3 HIS A 398
HIS A 396
HIS A 350
 ZN  A   2 (-3.2A)
ZN  A   2 (-3.2A)
ZN  A   2 (-3.3A)
 0.62A 5zrdA-3rzvA:
undetectable		 5zrdA-3rzvA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s0m OXALATE
DECARBOXYLASE OXDC

(Bacillus
subtilis) 		PF00190
(Cupin_1) 		3 HIS A 273
HIS A 319
HIS A 275
 MN  A 501 (-3.5A)
MN  A 501 (-3.4A)
MN  A 501 (-3.4A)
 0.44A 5zrdA-3s0mA:
undetectable		 5zrdA-3s0mA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4l CAS3 METAL DEPENDENT
PHOSPHOHYDROLASE

(Methanocaldococcus
jannaschii) 		no annotation 3 HIS A 124
HIS A 123
HIS A  91
 CA  A 501 (-3.4A)
CA  A 501 (-3.5A)
CA  A 501 (-3.5A)
 0.49A 5zrdA-3s4lA:
undetectable		 5zrdA-3s4lA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t9o DIGUANYLATE CYCLASE
DGCZ

(Escherichia
coli) 		no annotation 3 HIS A  79
HIS A  83
HIS A  22
 ZN  A 502 (-3.3A)
ZN  A 502 (-3.3A)
ZN  A 502 (-3.3A)
 0.31A 5zrdA-3t9oA:
undetectable		 5zrdA-3t9oA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6q TYROSINASE

(Aspergillus
oryzae) 		PF00264
(Tyrosinase) 		3 HIS A 328
HIS A 332
HIS A 372
 None
 0.26A 5zrdA-3w6qA:
24.1		 5zrdA-3w6qA:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wky PROPHENOLOXIDASE B

(Marsupenaeus
japonicus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 HIS A 357
HIS A 361
HIS A 397
 CUO  A 708 (-3.3A)
CUO  A 708 (-3.2A)
CUO  A 708 (-3.4A)
 0.16A 5zrdA-3wkyA:
8.7		 5zrdA-3wkyA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ww3 L-RIBOSE ISOMERASE

(Cellulomonas
parahominis) 		no annotation 3 HIS A 106
HIS A 188
HIS A 108
 MN  A 401 (-3.4A)
MN  A 401 (-3.5A)
MN  A 401 (-3.3A)
 0.36A 5zrdA-3ww3A:
undetectable		 5zrdA-3ww3A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a7k ALDOS-2-ULOSE
DEHYDRATASE

(Phanerochaete
chrysosporium) 		no annotation 3 HIS A 630
HIS A 709
HIS A 632
 ZN  A 952 ( 3.3A)
ZN  A 952 (-3.3A)
ZN  A 952 (-3.3A)
 0.48A 5zrdA-4a7kA:
undetectable		 5zrdA-4a7kA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		3 HIS B3106
HIS B2974
HIS B3075
 CUO  B9008 (-3.3A)
CUO  B9008 (-2.9A)
CUO  B9008 (-2.8A)
 0.55A 5zrdA-4bedB:
30.3		 5zrdA-4bedB:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bif CUPIN 2 CONSERVED
BARREL DOMAIN
PROTEIN

(Granulicella
tundricola) 		PF07883
(Cupin_2) 		3 HIS A  53
HIS A  94
HIS A  55
 MN  A1132 (-3.3A)
MN  A1132 (-3.6A)
MN  A1132 (-3.4A)
 0.46A 5zrdA-4bifA:
undetectable		 5zrdA-4bifA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gul PIRIN

(Homo sapiens) 		PF02678
(Pirin)
PF05726
(Pirin_C) 		3 HIS A  56
HIS A 101
HIS A  58
 FE  A1001 (-3.4A)
FE  A1001 (-3.3A)
FE  A1001 (-3.4A)
 0.51A 5zrdA-4gulA:
undetectable		 5zrdA-4gulA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h54 DIGUANYLATE CYCLASE
YDEH

(Escherichia
coli) 		PF00990
(GGDEF) 		3 HIS A  79
HIS A  83
HIS A  22
 ZN  A 401 (-3.5A)
ZN  A 401 (-3.2A)
ZN  A 401 (-3.3A)
 0.35A 5zrdA-4h54A:
undetectable		 5zrdA-4h54A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h7l UNCHARACTERIZED
PROTEIN

(Planctopirus
limnophila) 		no annotation 3 HIS A  58
HIS A 101
HIS A  60
 CU  A 201 (-3.4A)
CU  A 201 (-3.8A)
CU  A 201 (-3.4A)
 0.34A 5zrdA-4h7lA:
undetectable		 5zrdA-4h7lA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3q CATECHOL OXIDASE

(Aspergillus
oryzae) 		PF00264
(Tyrosinase) 		3 HIS A 284
HIS A 288
HIS A 312
 CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
CU  A1002 (-3.2A)
 0.24A 5zrdA-4j3qA:
3.1		 5zrdA-4j3qA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4me4 METAL DEPENDENT
PHOSPHOHYDROLASE

(Persephonella
marina) 		PF01590
(GAF)
PF01966
(HD) 		3 HIS A 277
HIS A 276
HIS A 250
 FE  A 401 ( 3.3A)
FE  A 401 (-3.4A)
FE  A 401 ( 3.4A)
 0.47A 5zrdA-4me4A:
undetectable		 5zrdA-4me4A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ntm 6-CARBOXY-5,6,7,8-TE
TRAHYDROPTERIN
SYNTHASE

(Escherichia
coli) 		PF01242
(PTPS) 		3 HIS A  16
HIS A  33
HIS A  31
 ZN  A 201 ( 3.3A)
ZN  A 201 ( 3.2A)
ZN  A 201 ( 3.2A)
 0.55A 5zrdA-4ntmA:
undetectable		 5zrdA-4ntmA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oua LATENT FORM OF PPO4
TYROSINASE

(Agaricus
bisporus) 		PF00264
(Tyrosinase) 		3 HIS B 251
HIS B 255
HIS B 283
 CU1  B 602 (-3.2A)
CU1  B 602 (-3.1A)
CU1  B 602 (-3.0A)
 0.27A 5zrdA-4ouaB:
33.2		 5zrdA-4ouaB:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE

(Agaricus
bisporus) 		PF00264
(Tyrosinase) 		3 HIS A 251
HIS A 255
HIS A 283
 CU1  A 402 (-3.0A)
CU1  A 402 (-3.1A)
CU1  A 402 (-2.9A)
 0.33A 5zrdA-4ouaA:
32.1		 5zrdA-4ouaA:
27.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p9g 2,4'-DIHYDROXYACETOP
HENONE DIOXYGENASE

(Alcaligenes sp.) 		PF07883
(Cupin_2) 		3 HIS A  76
HIS A 114
HIS A  78
 FE  A 401 ( 3.1A)
FE  A 401 ( 3.2A)
FE  A 401 ( 3.1A)
 0.36A 5zrdA-4p9gA:
undetectable		 5zrdA-4p9gA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0s L-RIBOSE ISOMERASE

(Acinetobacter
sp. DL-28) 		no annotation 3 HIS A 106
HIS A 188
HIS A 108
 CO  A 501 ( 3.5A)
CO  A 501 ( 3.5A)
CO  A 501 ( 3.3A)
 0.37A 5zrdA-4q0sA:
undetectable		 5zrdA-4q0sA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2c CRISPR-ASSOCIATED
HELICASE CAS3

(Thermobaculum
terrenum) 		PF00271
(Helicase_C) 		3 HIS A 172
HIS A 171
HIS A 138
 NI  A1002 ( 3.3A)
NI  A1002 (-3.3A)
NI  A1002 (-3.3A)
 0.47A 5zrdA-4q2cA:
undetectable		 5zrdA-4q2cA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qgl ACIREDUCTONE
DIOXYGENASE

(Bacillus
anthracis) 		PF03079
(ARD) 		3 HIS A  99
HIS A 144
HIS A 101
 CD  A 201 (-3.5A)
CD  A 201 (-3.7A)
CD  A 201 (-3.5A)
 0.42A 5zrdA-4qglA:
undetectable		 5zrdA-4qglA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qgn 1,2-DIHYDROXY-3-KETO
-5-METHYLTHIOPENTENE
DIOXYGENASE

(Homo sapiens) 		PF03079
(ARD) 		3 HIS A  88
HIS A 133
HIS A  90
 FE  A 201 (-3.4A)
FE  A 201 (-3.3A)
FE  A 201 (-3.3A)
 0.54A 5zrdA-4qgnA:
undetectable		 5zrdA-4qgnA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8z CYCLIC DI-GMP
PHOSPHODIESTERASE

(Pseudomonas
aeruginosa) 		PF13487
(HD_5) 		3 HIS A 282
HIS A 281
HIS A 249
 NI  A 402 (-3.2A)
NI  A 402 (-3.2A)
NI  A 402 (-3.2A)
 0.48A 5zrdA-4r8zA:
undetectable		 5zrdA-4r8zA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvp SUPEROXIDE DISMUTASE

(Sedum alfredii) 		PF00080
(Sod_Cu) 		3 HIS A  60
HIS A  75
HIS A 132
 None
ZN  A 201 (-3.2A)
None
 0.60A 5zrdA-4rvpA:
undetectable		 5zrdA-4rvpA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1b LMO1466 PROTEIN

(Listeria
monocytogenes) 		PF01966
(HD) 		3 HIS A 605
HIS A 604
HIS A 580
 FE  A 801 ( 3.5A)
FE  A 801 (-3.5A)
FE  A 801 ( 3.5A)
 0.46A 5zrdA-4s1bA:
undetectable		 5zrdA-4s1bA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u4i CU/ZN SUPEROXIDE
DISMUTASE

(Megavirus
chiliensis) 		PF00080
(Sod_Cu) 		3 HIS A  56
HIS A  71
HIS A 128
 None
 0.57A 5zrdA-4u4iA:
undetectable		 5zrdA-4u4iA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uxa CUPIN 2 CONSERVED
BARREL DOMAIN
PROTEIN

(Granulicella
tundricola) 		PF07883
(Cupin_2) 		3 HIS A  53
HIS A  94
HIS A  55
 MN  A 200 (-3.6A)
MN  A 200 (-3.6A)
MN  A 200 (-3.7A)
 0.48A 5zrdA-4uxaA:
undetectable		 5zrdA-4uxaA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uxa CUPIN 2 CONSERVED
BARREL DOMAIN
PROTEIN

(Granulicella
tundricola) 		PF07883
(Cupin_2) 		3 HIS A  94
HIS A  53
HIS A  96
 MN  A 200 (-3.6A)
MN  A 200 (-3.6A)
MN  A 200 (-3.7A)
 0.59A 5zrdA-4uxaA:
undetectable		 5zrdA-4uxaA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ymk ACYL-COA DESATURASE
1

(Mus musculus) 		PF00487
(FA_desaturase) 		3 HIS A 116
HIS A 121
HIS A 153
 ZN  A 401 ( 3.5A)
ZN  A 401 (-3.4A)
ZN  A 401 ( 3.2A)
 0.54A 5zrdA-4ymkA:
undetectable		 5zrdA-4ymkA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yrd CAPSULAR
POLYSACCHARIDE
SYNTHESIS ENZYME
CAP5F

(Staphylococcus
aureus) 		PF01370
(Epimerase) 		3 HIS A 288
HIS A 337
HIS A 290
 ZN  A 401 ( 3.4A)
ZN  A 401 ( 3.7A)
None
 0.59A 5zrdA-4yrdA:
undetectable		 5zrdA-4yrdA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzw AGAP004976-PA

(Anopheles
gambiae) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 HIS A 379
HIS A 383
HIS A 419
 CU  A 802 (-3.2A)
CU  A 802 (-3.2A)
CU  A 802 (-3.1A)
 0.20A 5zrdA-4yzwA:
undetectable		 5zrdA-4yzwA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z11 AURONE SYNTHASE

(Coreopsis
grandiflora) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL)
PF12143
(PPO1_KFDV) 		3 HIS A 252
HIS A 256
HIS A 286
 CU  A 701 (-3.1A)
CU  A 701 (-3.1A)
CU  A 701 (-3.1A)
 0.23A 5zrdA-4z11A:
19.6		 5zrdA-4z11A:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr0 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		3 HIS A 326
HIS A 330
HIS A 345
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.3A)
ZN  A 401 (-3.5A)
 0.59A 5zrdA-4zr0A:
undetectable		 5zrdA-4zr0A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zyo ACYL-COA DESATURASE

(Homo sapiens) 		no annotation 3 HIS A 120
HIS A 125
HIS A 157
 ZN  A 401 ( 3.3A)
ZN  A 401 (-3.2A)
ZN  A 401 ( 3.2A)
 0.50A 5zrdA-4zyoA:
undetectable		 5zrdA-4zyoA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aq6 METAL-BINDING
PROTEIN ZINT

(Escherichia
coli) 		PF09223
(ZinT) 		3 HIS A 153
HIS A 144
HIS A 155
 ZN  A1195 (-3.3A)
ZN  A1195 (-3.2A)
ZN  A1195 (-3.1A)
 0.59A 5zrdA-5aq6A:
undetectable		 5zrdA-5aq6A:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aq6 METAL-BINDING
PROTEIN ZINT

(Escherichia
coli) 		PF09223
(ZinT) 		3 HIS A 155
HIS A 153
HIS A 144
 ZN  A1195 (-3.1A)
ZN  A1195 (-3.3A)
ZN  A1195 (-3.2A)
 0.50A 5zrdA-5aq6A:
undetectable		 5zrdA-5aq6A:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5avp L-RIBOSE ISOMERASE

(Geodermatophilus
obscurus) 		no annotation 3 HIS A 110
HIS A 192
HIS A 112
 MN  A 401 (-3.4A)
MN  A 401 (-3.5A)
MN  A 401 (-3.5A)
 0.42A 5zrdA-5avpA:
undetectable		 5zrdA-5avpA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST

(Pseudomonas
aeruginosa) 		no annotation 3 HIS A 221
HIS A 220
HIS A 149
 CA  A1101 (-3.5A)
CA  A1101 (-3.7A)
CA  A1101 (-3.8A)
 0.42A 5zrdA-5b7iA:
undetectable		 5zrdA-5b7iA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bpx 2,4'-DIHYDROXYACETOP
HENONE DIOXYGENASE

(Alcaligenes sp.) 		PF07883
(Cupin_2) 		3 HIS A  76
HIS A 114
HIS A  78
 FE  A 201 ( 3.1A)
FE  A 201 ( 3.2A)
FE  A 201 ( 3.2A)
 0.39A 5zrdA-5bpxA:
undetectable		 5zrdA-5bpxA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ce9 POLYPHENOL OXIDASE

(Juglans regia) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		3 HIS A 239
HIS A 243
HIS A 273
 CU  A 401 ( 3.2A)
CU  A 401 ( 3.2A)
CU  A 401 ( 3.2A)
 0.13A 5zrdA-5ce9A:
3.1		 5zrdA-5ce9A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5flj QUERCETINASE QUED

(Streptomyces
sp. FLA) 		PF07883
(Cupin_2) 		3 HIS A  69
HIS A 115
HIS A  71
 QUE  A 301 ( 3.0A)
NI  A 300 (-3.2A)
NI  A 300 ( 3.3A)
 0.51A 5zrdA-5fljA:
undetectable		 5zrdA-5fljA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fpz PECTIN DEGRADATION
PROTEIN

(Yersinia
enterocolitica) 		PF07883
(Cupin_2) 		3 HIS A  46
HIS A  87
HIS A  48
 NI  A1111 ( 3.4A)
NI  A1111 ( 3.3A)
NI  A1111 ( 3.3A)
 0.45A 5zrdA-5fpzA:
undetectable		 5zrdA-5fpzA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fq0 KDGF

(Halomonas sp.) 		PF07883
(Cupin_2) 		3 HIS B  48
HIS B  89
HIS B  50
 FLC  B1114 ( 3.3A)
NI  B1113 ( 3.3A)
NI  B1113 ( 3.3A)
 0.42A 5zrdA-5fq0B:
undetectable		 5zrdA-5fq0B:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3a TYROSINASE

(Bacillus
megaterium) 		PF00264
(Tyrosinase) 		3 HIS A 204
HIS A 208
HIS A 231
 ZN  A 302 ( 3.4A)
HQE  A 303 ( 3.0A)
ZN  A 302 (-3.1A)
 0.14A 5zrdA-5i3aA:
3.4		 5zrdA-5i3aA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i93 1,2-DIHYDROXY-3-KETO
-5-METHYLTHIOPENTENE
DIOXYGENASE

(Mus musculus) 		PF03079
(ARD) 		3 HIS A  88
HIS A 133
HIS A  90
 NI  A 201 (-3.3A)
NI  A 201 (-3.3A)
NI  A 201 (-3.3A)
 0.51A 5zrdA-5i93A:
undetectable		 5zrdA-5i93A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8d COAGULATION FACTOR
VIII

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		3 HIS A 315
HIS A 267
HIS A 232
 CU  A 808 (-2.7A)
CU  A 808 (-2.5A)
CU  A 808 ( 4.6A)
 0.59A 5zrdA-5k8dA:
undetectable		 5zrdA-5k8dA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE

(Homo sapiens) 		PF00264
(Tyrosinase) 		3 HIS A 377
HIS A 381
HIS A 404
 ZN  A 511 ( 3.2A)
ZN  A 511 ( 3.3A)
ZN  A 511 (-3.1A)
 0.12A 5zrdA-5m8tA:
9.7		 5zrdA-5m8tA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5or4 CATECHOL OXIDASE

(Aspergillus
oryzae) 		no annotation 3 HIS A 284
HIS A 288
HIS A 312
 CU  A2002 (-3.2A)
CU  A2002 (-3.2A)
CU  A2002 (-3.1A)
 0.26A 5zrdA-5or4A:
2.9		 5zrdA-5or4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d0g PIRIN FAMILY PROTEIN

(Acinetobacter
baumannii) 		no annotation 3 HIS A  76
HIS A 120
HIS A  78
 MN  A 401 (-3.4A)
MN  A 401 (-3.4A)
MN  A 401 (-3.5A)
 0.58A 5zrdA-6d0gA:
undetectable		 5zrdA-6d0gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d0p PIRIN FAMILY PROTEIN

(Acinetobacter
baumannii) 		no annotation 3 HIS A  61
HIS A 105
HIS A  63
 MN  A 303 ( 3.3A)
MN  A 303 (-3.4A)
MN  A 303 (-3.4A)
 0.52A 5zrdA-6d0pA:
undetectable		 5zrdA-6d0pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eys -

(-) 		no annotation 3 HIS B 375
HIS B 379
HIS B 432
 None
 0.33A 5zrdA-6eysB:
4.6		 5zrdA-6eysB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eys -

(-) 		no annotation 3 HIS B 432
HIS B 271
HIS B 375
 None
 0.59A 5zrdA-6eysB:
4.6		 5zrdA-6eysB:
undetectable