SIMILAR PATTERNS OF AMINO ACIDS FOR 5ZRD_A_CUA606_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ck7 PROTEIN (GELATINASE
A)

(Homo sapiens) 		PF00040
(fn2)
PF00045
(Hemopexin)
PF00413
(Peptidase_M10)
PF01471
(PG_binding_1) 		4 HIS A 403
CYH A 102
HIS A 413
HIS A 407
 ZN  A 990 ( 3.4A)
ZN  A 990 ( 2.5A)
ZN  A 990 ( 3.4A)
ZN  A 990 ( 3.3A)
 1.50A 5zrdA-1ck7A:
undetectable		 5zrdA-1ck7A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dfx DESULFOFERRODOXIN

(Desulfovibrio
desulfuricans) 		PF01880
(Desulfoferrodox)
PF06397
(Desulfoferrod_N) 		4 HIS A  48
CYH A 115
HIS A  74
HIS A  68
 FE  A 132 (-3.4A)
FE  A 132 (-2.2A)
FE  A 132 (-3.4A)
FE  A 132 (-3.2A)
 1.19A 5zrdA-1dfxA:
undetectable		 5zrdA-1dfxA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dfx DESULFOFERRODOXIN

(Desulfovibrio
desulfuricans) 		PF01880
(Desulfoferrodox)
PF06397
(Desulfoferrod_N) 		4 HIS A  74
CYH A 115
HIS A  68
HIS A  48
 FE  A 132 (-3.4A)
FE  A 132 (-2.2A)
FE  A 132 (-3.2A)
FE  A 132 (-3.4A)
 1.46A 5zrdA-1dfxA:
undetectable		 5zrdA-1dfxA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dfx DESULFOFERRODOXIN

(Desulfovibrio
desulfuricans) 		PF01880
(Desulfoferrodox)
PF06397
(Desulfoferrod_N) 		4 HIS A 118
CYH A 115
HIS A  74
HIS A  68
 FE  A 132 (-3.2A)
FE  A 132 (-2.2A)
FE  A 132 (-3.4A)
FE  A 132 (-3.2A)
 1.26A 5zrdA-1dfxA:
undetectable		 5zrdA-1dfxA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1do6 SUPEROXIDE REDUCTASE

(Pyrococcus
furiosus) 		PF01880
(Desulfoferrodox) 		4 HIS A  16
CYH A 111
HIS A  47
HIS A  41
 FE  A 200 (-3.3A)
FE  A 200 (-2.4A)
FE  A 200 (-3.4A)
FE  A 200 (-3.3A)
 1.15A 5zrdA-1do6A:
undetectable		 5zrdA-1do6A:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1do6 SUPEROXIDE REDUCTASE

(Pyrococcus
furiosus) 		PF01880
(Desulfoferrodox) 		4 HIS A  47
CYH A 111
HIS A  16
HIS A 114
 FE  A 200 (-3.4A)
FE  A 200 (-2.4A)
FE  A 200 (-3.3A)
FE  A 200 (-3.2A)
 1.49A 5zrdA-1do6A:
undetectable		 5zrdA-1do6A:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1do6 SUPEROXIDE REDUCTASE

(Pyrococcus
furiosus) 		PF01880
(Desulfoferrodox) 		4 HIS A 114
CYH A 111
HIS A  47
HIS A  16
 FE  A 200 (-3.2A)
FE  A 200 (-2.4A)
FE  A 200 (-3.4A)
FE  A 200 (-3.3A)
 1.48A 5zrdA-1do6A:
undetectable		 5zrdA-1do6A:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1do6 SUPEROXIDE REDUCTASE

(Pyrococcus
furiosus) 		PF01880
(Desulfoferrodox) 		4 HIS A 114
CYH A 111
HIS A  47
HIS A  41
 FE  A 200 (-3.2A)
FE  A 200 (-2.4A)
FE  A 200 (-3.4A)
FE  A 200 (-3.3A)
 1.24A 5zrdA-1do6A:
undetectable		 5zrdA-1do6A:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js8 HEMOCYANIN

(Enteroctopus
dofleini) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS A2543
CYH A2560
HIS A2562
HIS A2571
 CUO  A 888 (-3.4A)
CUO  A 888 ( 3.8A)
CUO  A 888 (-3.4A)
CUO  A 888 (-3.3A)
 0.24A 5zrdA-1js8A:
27.5		 5zrdA-1js8A:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l6j MATRIX
METALLOPROTEINASE-9

(Homo sapiens) 		PF00040
(fn2)
PF00413
(Peptidase_M10)
PF01471
(PG_binding_1) 		4 HIS A 401
CYH A  99
HIS A 411
HIS A 405
 ZN  A 500 (-3.4A)
ZN  A 500 (-2.3A)
ZN  A 500 (-3.4A)
ZN  A 500 (-3.2A)
 1.44A 5zrdA-1l6jA:
undetectable		 5zrdA-1l6jA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lnl HEMOCYANIN

(Rapana venosa) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS A  41
CYH A  59
HIS A  61
HIS A  70
 CU  A5001 (-2.9A)
CU  A5001 (-3.4A)
CU  A5001 (-3.6A)
CU  A5001 ( 3.1A)
 0.50A 5zrdA-1lnlA:
26.7		 5zrdA-1lnlA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1slm STROMELYSIN-1

(Homo sapiens) 		PF00413
(Peptidase_M10)
PF01471
(PG_binding_1) 		4 HIS A 201
CYH A  75
HIS A 211
HIS A 205
 ZN  A 257 ( 3.0A)
ZN  A 257 ( 2.1A)
ZN  A 257 ( 3.1A)
ZN  A 257 ( 3.2A)
 1.40A 5zrdA-1slmA:
undetectable		 5zrdA-1slmA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1su3 INTERSTITIAL
COLLAGENASE

(Homo sapiens) 		PF00045
(Hemopexin)
PF00413
(Peptidase_M10)
PF01471
(PG_binding_1) 		4 HIS A 218
CYH A  92
HIS A 228
HIS A 222
 ZN  A 913 (-3.2A)
ZN  A 913 (-2.2A)
ZN  A 913 (-3.2A)
ZN  A 913 (-3.2A)
 1.42A 5zrdA-1su3A:
0.0		 5zrdA-1su3A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vzh DESULFOFERRODOXIN

(Desulfarculus
baarsii) 		PF01880
(Desulfoferrodox)
PF06397
(Desulfoferrod_N) 		4 HIS A  49
CYH A 116
HIS A  75
HIS A  69
 FE  A1129 ( 3.4A)
FE  A1129 (-2.7A)
FE  A1129 ( 3.4A)
FE  A1129 ( 3.4A)
 1.22A 5zrdA-1vzhA:
undetectable		 5zrdA-1vzhA:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vzh DESULFOFERRODOXIN

(Desulfarculus
baarsii) 		PF01880
(Desulfoferrodox)
PF06397
(Desulfoferrod_N) 		4 HIS A  75
CYH A 116
HIS A  69
HIS A  49
 FE  A1129 ( 3.4A)
FE  A1129 (-2.7A)
FE  A1129 ( 3.4A)
FE  A1129 ( 3.4A)
 1.46A 5zrdA-1vzhA:
undetectable		 5zrdA-1vzhA:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vzh DESULFOFERRODOXIN

(Desulfarculus
baarsii) 		PF01880
(Desulfoferrodox)
PF06397
(Desulfoferrod_N) 		4 HIS A 119
CYH A 116
HIS A  75
HIS A  69
 FE  A1129 ( 3.2A)
FE  A1129 (-2.7A)
FE  A1129 ( 3.4A)
FE  A1129 ( 3.4A)
 1.30A 5zrdA-1vzhA:
undetectable		 5zrdA-1vzhA:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y07 DESULFOFERRODOXIN
(RBO)

(Treponema
pallidum) 		PF01880
(Desulfoferrodox) 		4 HIS A  50
CYH A 119
HIS A  76
HIS A  70
 FE  A 130 (-3.4A)
FE  A 130 (-2.3A)
FE  A 130 (-3.5A)
FE  A 130 (-3.3A)
 1.22A 5zrdA-1y07A:
undetectable		 5zrdA-1y07A:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y07 DESULFOFERRODOXIN
(RBO)

(Treponema
pallidum) 		PF01880
(Desulfoferrodox) 		4 HIS A  76
CYH A 119
HIS A  50
HIS A 122
 FE  A 130 (-3.5A)
FE  A 130 (-2.3A)
FE  A 130 (-3.4A)
FE  A 130 (-3.3A)
 1.49A 5zrdA-1y07A:
undetectable		 5zrdA-1y07A:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y07 DESULFOFERRODOXIN
(RBO)

(Treponema
pallidum) 		PF01880
(Desulfoferrodox) 		4 HIS A  76
CYH A 119
HIS A  70
HIS A  50
 FE  A 130 (-3.5A)
FE  A 130 (-2.3A)
FE  A 130 (-3.3A)
FE  A 130 (-3.4A)
 1.50A 5zrdA-1y07A:
undetectable		 5zrdA-1y07A:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y07 DESULFOFERRODOXIN
(RBO)

(Treponema
pallidum) 		PF01880
(Desulfoferrodox) 		4 HIS A 122
CYH A 119
HIS A  76
HIS A  50
 FE  A 130 (-3.3A)
FE  A 130 (-2.3A)
FE  A 130 (-3.5A)
FE  A 130 (-3.4A)
 1.42A 5zrdA-1y07A:
undetectable		 5zrdA-1y07A:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y07 DESULFOFERRODOXIN
(RBO)

(Treponema
pallidum) 		PF01880
(Desulfoferrodox) 		4 HIS A 122
CYH A 119
HIS A  76
HIS A  70
 FE  A 130 (-3.3A)
FE  A 130 (-2.3A)
FE  A 130 (-3.5A)
FE  A 130 (-3.3A)
 1.33A 5zrdA-1y07A:
undetectable		 5zrdA-1y07A:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ysj PROTEIN YXEP

(Bacillus
subtilis) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 HIS A 158
CYH A  98
HIS A 100
HIS A 103
 NI  A 381 (-3.4A)
NI  A 381 ( 2.5A)
NI  A 381 (-3.2A)
None
 1.42A 5zrdA-1ysjA:
undetectable		 5zrdA-1ysjA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmh ELECTRON TRANSFER
FLAVOPROTEIN-UBIQUIN
ONE OXIDOREDUCTASE

(Sus scrofa) 		PF05187
(ETF_QO)
PF13450
(NAD_binding_8) 		4 HIS A 555
CYH A 553
HIS A 503
HIS A 496
 None
SF4  A 610 (-2.3A)
None
None
 1.01A 5zrdA-2gmhA:
undetectable		 5zrdA-2gmhA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hvb SUPEROXIDE REDUCTASE

(Pyrococcus
horikoshii) 		PF01880
(Desulfoferrodox) 		4 HIS A  25
CYH A 111
HIS A  56
HIS A  50
 FE  A 201 (-3.3A)
FE  A 201 (-2.2A)
FE  A 201 (-3.4A)
FE  A 201 (-3.5A)
 1.18A 5zrdA-2hvbA:
undetectable		 5zrdA-2hvbA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hvb SUPEROXIDE REDUCTASE

(Pyrococcus
horikoshii) 		PF01880
(Desulfoferrodox) 		4 HIS A  56
CYH A 111
HIS A  25
HIS A 114
 FE  A 201 (-3.4A)
FE  A 201 (-2.2A)
FE  A 201 (-3.3A)
FE  A 201 (-3.2A)
 1.43A 5zrdA-2hvbA:
undetectable		 5zrdA-2hvbA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hvb SUPEROXIDE REDUCTASE

(Pyrococcus
horikoshii) 		PF01880
(Desulfoferrodox) 		4 HIS A 114
CYH A 111
HIS A  56
HIS A  25
 FE  A 201 (-3.2A)
FE  A 201 (-2.2A)
FE  A 201 (-3.4A)
FE  A 201 (-3.3A)
 1.42A 5zrdA-2hvbA:
undetectable		 5zrdA-2hvbA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hvb SUPEROXIDE REDUCTASE

(Pyrococcus
horikoshii) 		PF01880
(Desulfoferrodox) 		4 HIS A 114
CYH A 111
HIS A  56
HIS A  50
 FE  A 201 (-3.2A)
FE  A 201 (-2.2A)
FE  A 201 (-3.4A)
FE  A 201 (-3.5A)
 1.26A 5zrdA-2hvbA:
undetectable		 5zrdA-2hvbA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l0z GLYCOPROTEIN G2

(Argentinian
mammarenavirus) 		PF00798
(Arena_glycoprot) 		4 HIS A 447
CYH A 455
HIS A 449
HIS A 485
 ZN  A 486 (-3.3A)
ZN  A 486 (-2.3A)
ZN  A 486 (-3.3A)
ZN  A 486 (-3.3A)
 1.47A 5zrdA-2l0zA:
undetectable		 5zrdA-2l0zA:
6.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9x POLYPHENOL OXIDASE

(Agaricus
bisporus) 		PF00264
(Tyrosinase) 		4 HIS A  61
CYH A  83
HIS A  85
HIS A  94
 CU  A 400 (-3.2A)
CU  A 400 (-3.7A)
CU  A 400 (-3.3A)
CU  A 400 (-3.2A)
 0.17A 5zrdA-2y9xA:
12.2		 5zrdA-2y9xA:
26.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qzb PUTATIVE SUPEROXIDE
REDUCTASE

(Thermotoga
maritima) 		PF01880
(Desulfoferrodox) 		4 HIS A  17
CYH A 115
HIS A  51
HIS A  45
 FE  A 132 (-3.4A)
FE  A 132 (-2.3A)
FE  A 132 (-3.4A)
FE  A 132 (-3.4A)
 1.20A 5zrdA-3qzbA:
1.8		 5zrdA-3qzbA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qzb PUTATIVE SUPEROXIDE
REDUCTASE

(Thermotoga
maritima) 		PF01880
(Desulfoferrodox) 		4 HIS A 118
CYH A 115
HIS A  51
HIS A  45
 FE  A 132 (-3.3A)
FE  A 132 (-2.3A)
FE  A 132 (-3.4A)
FE  A 132 (-3.4A)
 1.27A 5zrdA-3qzbA:
1.8		 5zrdA-3qzbA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6q TYROSINASE

(Aspergillus
oryzae) 		PF00264
(Tyrosinase) 		4 HIS A  67
CYH A  92
HIS A  94
HIS A 103
 None
 0.85A 5zrdA-3w6qA:
24.1		 5zrdA-3w6qA:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6q TYROSINASE

(Aspergillus
oryzae) 		PF00264
(Tyrosinase) 		4 HIS A  94
CYH A  92
HIS A 103
HIS A  67
 None
 1.12A 5zrdA-3w6qA:
24.1		 5zrdA-3w6qA:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS A  42
CYH A  58
HIS A  60
HIS A  69
 CUO  A9001 (-3.4A)
CUO  A9001 ( 4.2A)
CUO  A9001 (-3.1A)
CUO  A9001 (-3.1A)
 0.50A 5zrdA-4bedA:
10.3		 5zrdA-4bedA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS A 462
CYH A 480
HIS A 482
HIS A 491
 CUO  A9002 (-3.2A)
CUO  A9002 (-3.2A)
CUO  A9002 (-3.4A)
CUO  A9002 (-3.4A)
 0.96A 5zrdA-4bedA:
10.3		 5zrdA-4bedA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS A 482
CYH A 480
HIS A 491
HIS A 462
 CUO  A9002 (-3.4A)
CUO  A9002 (-3.2A)
CUO  A9002 (-3.4A)
CUO  A9002 (-3.2A)
 1.09A 5zrdA-4bedA:
10.3		 5zrdA-4bedA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS A 491
CYH A 480
HIS A 462
HIS A 482
 CUO  A9002 (-3.4A)
CUO  A9002 (-3.2A)
CUO  A9002 (-3.2A)
CUO  A9002 (-3.4A)
 1.21A 5zrdA-4bedA:
10.3		 5zrdA-4bedA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS A 876
CYH A 894
HIS A 896
HIS A 905
 CUO  A9003 (-3.3A)
CUO  A9003 (-3.1A)
CUO  A9003 (-3.4A)
CUO  A9003 (-3.5A)
 0.94A 5zrdA-4bedA:
10.3		 5zrdA-4bedA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS A 896
CYH A 894
HIS A 905
HIS A 876
 CUO  A9003 (-3.4A)
CUO  A9003 (-3.1A)
CUO  A9003 (-3.5A)
CUO  A9003 (-3.3A)
 1.07A 5zrdA-4bedA:
10.3		 5zrdA-4bedA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS A 905
CYH A 894
HIS A 876
HIS A 896
 CUO  A9003 (-3.5A)
CUO  A9003 (-3.1A)
CUO  A9003 (-3.3A)
CUO  A9003 (-3.4A)
 1.28A 5zrdA-4bedA:
10.3		 5zrdA-4bedA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS A1293
CYH A1309
HIS A1311
HIS A1320
 CUO  A9004 (-3.2A)
CUO  A9004 ( 3.9A)
CUO  A9004 (-3.4A)
CUO  A9004 (-3.5A)
 0.90A 5zrdA-4bedA:
10.3		 5zrdA-4bedA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS A1320
CYH A1309
HIS A1293
HIS A1311
 CUO  A9004 (-3.5A)
CUO  A9004 ( 3.9A)
CUO  A9004 (-3.2A)
CUO  A9004 (-3.4A)
 1.13A 5zrdA-4bedA:
10.3		 5zrdA-4bedA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS B2122
CYH B2139
HIS B2141
HIS B2150
 CUO  B9006 (-3.2A)
CUO  B9006 (-3.6A)
CUO  B9006 (-3.1A)
CUO  B9006 (-3.3A)
 1.14A 5zrdA-4bedB:
30.3		 5zrdA-4bedB:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS B2141
CYH B2139
HIS B2150
HIS B2122
 CUO  B9006 (-3.1A)
CUO  B9006 (-3.6A)
CUO  B9006 (-3.3A)
CUO  B9006 (-3.2A)
 1.02A 5zrdA-4bedB:
30.3		 5zrdA-4bedB:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS B2570
CYH B2559
HIS B2542
HIS B2561
 CUO  B9007 (-3.3A)
CUO  B9007 ( 3.7A)
CUO  B9007 (-3.3A)
CUO  B9007 (-3.3A)
 1.09A 5zrdA-4bedB:
30.3		 5zrdA-4bedB:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 HIS B2946
CYH B2963
HIS B2965
HIS B2974
 CUO  B9008 (-3.1A)
CUO  B9008 (-3.0A)
CUO  B9008 (-3.2A)
CUO  B9008 (-2.9A)
 0.74A 5zrdA-4bedB:
30.3		 5zrdA-4bedB:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4brj DESULFOFERRODOXIN,
FERROUS IRON-BINDING
REGION

(Ignicoccus
hospitalis) 		PF01880
(Desulfoferrodox) 		4 HIS A  25
CYH A 109
HIS A  56
HIS A  50
 FE  A1125 (-3.3A)
FE  A1125 (-2.6A)
FE  A1125 (-3.5A)
FE  A1125 (-3.2A)
 1.26A 5zrdA-4brjA:
undetectable		 5zrdA-4brjA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4brj DESULFOFERRODOXIN,
FERROUS IRON-BINDING
REGION

(Ignicoccus
hospitalis) 		PF01880
(Desulfoferrodox) 		4 HIS A 112
CYH A 109
HIS A  56
HIS A  25
 FE  A1125 (-3.3A)
FE  A1125 (-2.6A)
FE  A1125 (-3.5A)
FE  A1125 (-3.3A)
 1.45A 5zrdA-4brjA:
undetectable		 5zrdA-4brjA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4brj DESULFOFERRODOXIN,
FERROUS IRON-BINDING
REGION

(Ignicoccus
hospitalis) 		PF01880
(Desulfoferrodox) 		4 HIS A 112
CYH A 109
HIS A  56
HIS A  50
 FE  A1125 (-3.3A)
FE  A1125 (-2.6A)
FE  A1125 (-3.5A)
FE  A1125 (-3.2A)
 1.20A 5zrdA-4brjA:
undetectable		 5zrdA-4brjA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bv1 NEQ011

(Nanoarchaeum
equitans) 		PF01880
(Desulfoferrodox) 		4 HIS A  10
CYH A  97
HIS A  41
HIS A  35
 FE  A 120 (-3.5A)
FE  A 120 (-2.5A)
FE  A 120 (-3.5A)
FE  A 120 (-3.4A)
 1.26A 5zrdA-4bv1A:
undetectable		 5zrdA-4bv1A:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bv1 NEQ011

(Nanoarchaeum
equitans) 		PF01880
(Desulfoferrodox) 		4 HIS A 100
CYH A  97
HIS A  41
HIS A  35
 FE  A 120 (-3.4A)
FE  A 120 (-2.5A)
FE  A 120 (-3.5A)
FE  A 120 (-3.4A)
 1.34A 5zrdA-4bv1A:
undetectable		 5zrdA-4bv1A:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c4b SUPEROXIDE REDUCTASE

(Archaeoglobus
fulgidus) 		PF01880
(Desulfoferrodox) 		4 HIS A  14
CYH A 110
HIS A  46
HIS A  40
 FE2  A1001 (-3.4A)
FE2  A1001 (-2.4A)
FE2  A1001 (-3.4A)
FE2  A1001 (-3.4A)
 1.23A 5zrdA-4c4bA:
1.9		 5zrdA-4c4bA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c4b SUPEROXIDE REDUCTASE

(Archaeoglobus
fulgidus) 		PF01880
(Desulfoferrodox) 		4 HIS A 113
CYH A 110
HIS A  46
HIS A  14
 FE2  A1001 (-3.2A)
FE2  A1001 (-2.4A)
FE2  A1001 (-3.4A)
FE2  A1001 (-3.4A)
 1.48A 5zrdA-4c4bA:
1.9		 5zrdA-4c4bA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c4b SUPEROXIDE REDUCTASE

(Archaeoglobus
fulgidus) 		PF01880
(Desulfoferrodox) 		4 HIS A 113
CYH A 110
HIS A  46
HIS A  40
 FE2  A1001 (-3.2A)
FE2  A1001 (-2.4A)
FE2  A1001 (-3.4A)
FE2  A1001 (-3.4A)
 1.24A 5zrdA-4c4bA:
1.9		 5zrdA-4c4bA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7p SUPEROXIDE REDUCTASE

(Giardia
intestinalis) 		PF01880
(Desulfoferrodox) 		4 HIS A  46
CYH A  99
HIS A  19
HIS A 102
 FE  A 201 (-3.3A)
FE  A 201 (-2.3A)
FE  A 201 (-3.2A)
FE  A 201 (-3.4A)
 1.42A 5zrdA-4d7pA:
2.3		 5zrdA-4d7pA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7p SUPEROXIDE REDUCTASE

(Giardia
intestinalis) 		PF01880
(Desulfoferrodox) 		4 HIS A 102
CYH A  99
HIS A  46
HIS A  19
 FE  A 201 (-3.4A)
FE  A 201 (-2.3A)
FE  A 201 (-3.3A)
FE  A 201 (-3.2A)
 1.42A 5zrdA-4d7pA:
2.3		 5zrdA-4d7pA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7p SUPEROXIDE REDUCTASE

(Giardia
intestinalis) 		PF01880
(Desulfoferrodox) 		4 HIS A 102
CYH A  99
HIS A  46
HIS A  40
 FE  A 201 (-3.4A)
FE  A 201 (-2.3A)
FE  A 201 (-3.3A)
FE  A 201 (-3.4A)
 1.27A 5zrdA-4d7pA:
2.3		 5zrdA-4d7pA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jiv PUTATIVE
UNCHARACTERIZED
PROTEIN

(Vibrio cholerae) 		PF05488
(PAAR_motif) 		4 HIS D  14
CYH D  81
HIS D  54
HIS D  46
 ZN  D 101 (-3.3A)
ZN  D 101 (-2.3A)
ZN  D 101 (-3.2A)
ZN  D 101 (-3.4A)
 1.44A 5zrdA-4jivD:
undetectable		 5zrdA-4jivD:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jiw PUTATIVE
UNCHARACTERIZED
PROTEIN

(Escherichia
coli) 		PF05488
(PAAR_motif) 		4 HIS D  14
CYH D  81
HIS D  54
HIS D  46
 ZN  D 101 (-3.2A)
ZN  D 101 (-2.3A)
ZN  D 101 (-2.9A)
ZN  D 101 (-3.1A)
 1.44A 5zrdA-4jiwD:
undetectable		 5zrdA-4jiwD:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ku0 UNCHARACTERIZED 10.2
KDA PROTEIN IN
SEGC-GP6 INTERGENIC
REGION

(Escherichia
virus T4) 		PF05488
(PAAR_motif) 		4 HIS D  14
CYH D  83
HIS D  56
HIS D  46
 FE  D 101 (-3.2A)
FE  D 101 (-2.3A)
FE  D 101 (-3.2A)
FE  D 101 (-3.2A)
 1.49A 5zrdA-4ku0D:
undetectable		 5zrdA-4ku0D:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nql AMSH-LIKE PROTEASE
SST2

(Schizosaccharomyces
pombe) 		PF01398
(JAB) 		4 HIS A 406
CYH A 397
HIS A 356
HIS A 404
 ZN  A 501 (-3.2A)
ZN  A 501 (-2.2A)
ZN  A 501 (-3.4A)
ZN  A 501 (-3.4A)
 1.31A 5zrdA-4nqlA:
undetectable		 5zrdA-4nqlA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oua LATENT FORM OF PPO4
TYROSINASE

(Agaricus
bisporus) 		PF00264
(Tyrosinase) 		4 HIS B  57
CYH B  80
HIS B  82
HIS B  91
 CU1  B 601 (-3.1A)
CU1  B 601 (-3.5A)
CU1  B 601 (-3.1A)
CU1  B 601 (-3.2A)
 0.15A 5zrdA-4ouaB:
33.2		 5zrdA-4ouaB:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE

(Agaricus
bisporus) 		PF00264
(Tyrosinase) 		4 HIS A  57
CYH A  80
HIS A  82
HIS A  91
 CU1  A 401 (-3.2A)
CU1  A 401 (-3.7A)
CU1  A 401 (-3.3A)
CU1  A 401 (-3.3A)
 0.16A 5zrdA-4ouaA:
32.1		 5zrdA-4ouaA:
27.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zd5 AMSH-LIKE PROTEASE
SST2

(Schizosaccharomyces
pombe) 		PF01398
(JAB) 		4 HIS A 406
CYH A 397
HIS A 356
HIS A 404
 ZN  A 502 (-3.1A)
ZN  A 502 (-2.3A)
ZN  A 502 (-3.2A)
ZN  A 502 (-3.1A)
 1.33A 5zrdA-4zd5A:
undetectable		 5zrdA-4zd5A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czw MYROILYSIN

(Myroides
profundi) 		PF01400
(Astacin) 		4 HIS A 142
CYH A  28
HIS A 152
HIS A 146
 ZN  A 301 ( 3.4A)
ZN  A 301 ( 2.3A)
ZN  A 301 ( 3.1A)
ZN  A 301 ( 3.3A)
 1.44A 5zrdA-5czwA:
undetectable		 5zrdA-5czwA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9

(Homo sapiens) 		PF00413
(Peptidase_M10)
PF01471
(PG_binding_1) 		4 HIS A 401
CYH A  99
HIS A 411
HIS A 405
 ZN  A 501 (-3.3A)
ZN  A 501 (-2.2A)
ZN  A 501 (-3.1A)
ZN  A 501 (-3.2A)
 1.43A 5zrdA-5th6A:
undetectable		 5zrdA-5th6A:
17.39