SIMILAR PATTERNS OF AMINO ACIDS FOR 5ZNI_A_YMZA302_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a4s BETAINE ALDEHYDE
DEHYDROGENASE

(Gadus morhua) 		PF00171
(Aldedh) 		5 GLY A 109
VAL A 105
GLU A 104
GLY A 338
PRO A 329
 None
 1.07A 5zniA-1a4sA:
undetectable		 5zniA-1a4sA:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bl5 ISOCITRATE
DEHYDROGENASE

(Escherichia
coli) 		PF00180
(Iso_dh) 		5 VAL A  49
GLY A  38
VAL A  41
MET A  45
GLY A  34
 None
 1.39A 5zniA-1bl5A:
undetectable		 5zniA-1bl5A:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6h CHALCONE SYNTHASE

(Medicago sativa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 VAL A 129
GLY A 218
VAL A 193
GLU A 192
PRO A  27
 None
 1.31A 5zniA-1d6hA:
undetectable		 5zniA-1d6hA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j71 ASPARTIC PROTEINASE

(Candida
tropicalis) 		PF00026
(Asp) 		5 VAL A 197
GLY A  34
TYR A 311
GLU A 194
GLY A 220
 None
 1.35A 5zniA-1j71A:
undetectable		 5zniA-1j71A:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kob TWITCHIN

(Aplysia
californica) 		PF00069
(Pkinase) 		5 VAL A  78
GLY A 346
TYR A  26
GLY A  60
PRO A 341
 None
 1.25A 5zniA-1kobA:
undetectable		 5zniA-1kobA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lwu FIBRINOGEN BETA
CHAIN

(Petromyzon
marinus) 		PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha) 		5 GLY B 434
TYR B 424
ASP B 453
GLY B 454
PRO B 432
 None
 1.30A 5zniA-1lwuB:
undetectable		 5zniA-1lwuB:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m64 FLAVOCYTOCHROME C3

(Shewanella
frigidimarina) 		PF00890
(FAD_binding_2)
PF14537
(Cytochrom_c3_2) 		5 VAL A 525
GLY A 537
VAL A 510
ASP A 205
GLY A 538
 None
NA  A3002 ( 4.5A)
None
None
None
 1.40A 5zniA-1m64A:
undetectable		 5zniA-1m64A:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3s THERMOSOME ALPHA
SUBUNIT

(Thermococcus
sp. JCM 11816) 		PF00118
(Cpn60_TCP1) 		5 GLY A 478
VAL A 466
GLU A 469
ASP A 480
PRO A 448
 None
None
None
ADP  A1528 (-4.5A)
None
 1.21A 5zniA-1q3sA:
undetectable		 5zniA-1q3sA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3s THERMOSOME ALPHA
SUBUNIT

(Thermococcus
sp. JCM 11816) 		PF00118
(Cpn60_TCP1) 		5 GLY A 478
VAL A 466
GLU A 469
GLY A 411
PRO A 448
 None
None
None
ADP  A1528 (-3.4A)
None
 1.09A 5zniA-1q3sA:
undetectable		 5zniA-1q3sA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qz9 KYNURENINASE

(Pseudomonas
fluorescens) 		PF00266
(Aminotran_5) 		5 GLY A 294
TYR A 382
VAL A 297
GLY A 231
PRO A  41
 None
 1.21A 5zniA-1qz9A:
undetectable		 5zniA-1qz9A:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rhc F420-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Methanoculleus
thermophilus) 		PF00296
(Bac_luciferase) 		5 VAL A  36
GLY A 105
VAL A 104
GLY A 107
PRO A  76
 None
F42  A 351 ( 4.0A)
None
F42  A 351 (-3.2A)
None
 1.29A 5zniA-1rhcA:
undetectable		 5zniA-1rhcA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v43 SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN

(Pyrococcus
horikoshii) 		PF00005
(ABC_tran)
PF08402
(TOBE_2) 		5 GLY A 262
VAL A 253
GLU A 252
ASP A 333
GLY A 264
 None
 1.12A 5zniA-1v43A:
undetectable		 5zniA-1v43A:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v61 RAC/CDC42 GUANINE
NUCLEOTIDE EXCHANGE
FACTOR (GEF) 6

(Mus musculus) 		PF00169
(PH) 		5 VAL A 106
GLY A  98
GLU A 102
GLY A  78
PRO A  75
 None
 1.39A 5zniA-1v61A:
undetectable		 5zniA-1v61A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdv HYPOTHETICAL PROTEIN
APE2540

(Aeropyrum
pernix) 		PF04073
(tRNA_edit) 		5 GLY A 126
VAL A   5
GLU A   6
GLY A  97
PRO A  99
 None
 1.24A 5zniA-1wdvA:
undetectable		 5zniA-1wdvA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfd DIPEPTIDYL
AMINOPEPTIDASE-LIKE
PROTEIN 6

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		5 GLY A 664
VAL A 676
GLU A 675
GLY A 666
PRO A 632
 None
 1.34A 5zniA-1xfdA:
2.7		 5zniA-1xfdA:
7.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkd ISOCITRATE
DEHYDROGENASE

(Aeropyrum
pernix) 		PF00180
(Iso_dh) 		5 VAL A  58
GLY A  47
VAL A  50
GLY A  43
PRO A 109
 None
None
None
None
NAP  A1001 (-4.4A)
 1.11A 5zniA-1xkdA:
2.1		 5zniA-1xkdA:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlr COAGULATION FACTOR
XI

(Homo sapiens) 		PF00089
(Trypsin) 		5 VAL A 210
GLY A 184
TYR A 228
VAL A 163
PRO A 225
 None
 1.36A 5zniA-1zlrA:
undetectable		 5zniA-1zlrA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a87 THIOREDOXIN
REDUCTASE

(Mycobacterium
tuberculosis) 		PF07992
(Pyr_redox_2) 		5 VAL A 181
GLY A 141
VAL A 223
ASP A 149
GLY A 139
 None
None
None
FAD  A 348 (-3.4A)
None
 1.21A 5zniA-2a87A:
undetectable		 5zniA-2a87A:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4i OUTER CAPSID PROTEIN
VP4

(Rotavirus A) 		PF17477
(Rota_VP4_MID) 		5 VAL A 378
GLY A 400
GLU A 433
GLY A 399
PRO A 451
 None
 1.41A 5zniA-2b4iA:
undetectable		 5zniA-2b4iA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bex RIBONUCLEASE
INHIBITOR

(Homo sapiens) 		PF13516
(LRR_6) 		5 VAL A 335
GLY A 299
GLU A 305
ASP A 297
GLY A 296
 None
 1.27A 5zniA-2bexA:
undetectable		 5zniA-2bexA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bgs ALDOSE REDUCTASE

(Hordeum vulgare) 		PF00248
(Aldo_ket_red) 		5 VAL A 186
GLY A  28
VAL A  27
GLY A  30
PRO A 258
 None
None
None
NDP  A1321 (-3.3A)
NDP  A1321 (-4.6A)
 1.39A 5zniA-2bgsA:
undetectable		 5zniA-2bgsA:
15.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2bsx PURINE NUCLEOSIDE
PHOSPHORYLASE

(Plasmodium
falciparum) 		PF01048
(PNP_UDP_1) 		8 VAL A  66
GLY A  93
TYR A 160
VAL A 181
GLU A 182
MET A 183
GLY A 207
PRO A 209
 NOS  A1248 ( 3.8A)
NOS  A1248 (-4.0A)
NOS  A1248 (-4.7A)
NOS  A1248 ( 4.4A)
None
NOS  A1248 (-3.4A)
None
NOS  A1248 ( 4.1A)
 0.46A 5zniA-2bsxA:
42.1		 5zniA-2bsxA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bwj ADENYLATE KINASE 5

(Homo sapiens) 		PF00406
(ADK) 		5 GLY A 109
TYR A  98
GLU A 106
GLY A 113
PRO A 115
 None
 1.35A 5zniA-2bwjA:
3.1		 5zniA-2bwjA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cas CANINE PARVOVIRUS
EMPTY CAPSID (STRAIN
D) VIRAL PROTEIN 2

(Carnivore
protoparvovirus
1) 		PF00740
(Parvo_coat) 		5 VAL A  59
VAL A 130
MET A 133
ASP A 125
GLY A 124
 None
 1.40A 5zniA-2casA:
undetectable		 5zniA-2casA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ism PUTATIVE
OXIDOREDUCTASE

(Thermus
thermophilus) 		PF07995
(GSDH) 		5 VAL A  23
GLY A  28
VAL A  27
ASP A 345
GLY A 344
 None
 1.40A 5zniA-2ismA:
undetectable		 5zniA-2ismA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuc ALKALINE PHOSPHATASE

(Antarctic
bacterium TAB5) 		PF00245
(Alk_phosphatase) 		5 GLY B 350
VAL B 370
GLU B 353
GLY B 348
PRO B  34
 None
 1.41A 5zniA-2iucB:
undetectable		 5zniA-2iucB:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT

(Escherichia
coli) 		PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		5 VAL A 664
GLY A 619
VAL A 654
ASP A 617
GLY A 621
 None
 1.28A 5zniA-2jgdA:
undetectable		 5zniA-2jgdA:
6.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ov9 HYPOTHETICAL PROTEIN

(Rhodococcus
jostii) 		PF03061
(4HBT) 		5 VAL A 116
GLY A 176
VAL A 112
ASP A 191
GLY A 190
 None
 1.37A 5zniA-2ov9A:
undetectable		 5zniA-2ov9A:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00106
(adh_short)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 GLY A 689
TYR A 718
VAL A 692
GLU A 691
GLY A 682
 None
 1.39A 5zniA-2pffA:
2.3		 5zniA-2pffA:
6.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pi2 REPLICATION PROTEIN
A 14 KDA SUBUNIT

(Homo sapiens) 		PF08661
(Rep_fac-A_3) 		5 VAL E  25
GLY E  29
VAL E  67
GLU E  68
ASP E  45
 None
 1.19A 5zniA-2pi2E:
undetectable		 5zniA-2pi2E:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qde MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Aromatoleum
aromaticum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A 303
VAL A 349
ASP A  49
GLY A 301
PRO A 329
 None
 1.40A 5zniA-2qdeA:
undetectable		 5zniA-2qdeA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkx BIFUNCTIONAL PROTEIN
GLMU

(Mycobacterium
tuberculosis) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		5 VAL A 137
GLY A  90
TYR A 185
VAL A  93
ASP A 212
 None
 1.20A 5zniA-2qkxA:
3.2		 5zniA-2qkxA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uxt PROTEIN SUFI

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 GLY A  69
TYR A 141
VAL A  52
MET A  50
GLY A 156
 None
 1.25A 5zniA-2uxtA:
undetectable		 5zniA-2uxtA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w48 SORBITOL OPERON
REGULATOR

(Klebsiella
pneumoniae) 		PF04198
(Sugar-bind)
PF13936
(HTH_38) 		5 GLY A 242
TYR A 227
VAL A 240
GLY A 213
PRO A 215
 None
MPD  A1317 (-4.4A)
None
GOL  A1316 ( 3.7A)
None
 1.06A 5zniA-2w48A:
undetectable		 5zniA-2w48A:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wda PUTATIVE SECRETED
LYASE

(Streptomyces
violaceoruber) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		5 VAL A 553
GLY A 623
VAL A 549
GLU A 550
PRO A 626
 None
None
None
PEG  A1777 (-3.2A)
None
 1.20A 5zniA-2wdaA:
undetectable		 5zniA-2wdaA:
7.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wk1 NOVP

(Actinoalloteichus
cyanogriseus) 		PF05711
(TylF) 		5 VAL A 149
GLY A  98
VAL A 157
GLU A 156
GLY A  99
 None
 1.39A 5zniA-2wk1A:
undetectable		 5zniA-2wk1A:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxx DIAMINOPIMELATE
DECARBOXYLASE

(Thermotoga
maritima) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 VAL A 329
GLY A 311
VAL A 310
ASP A 277
GLY A 278
 None
 1.17A 5zniA-2yxxA:
undetectable		 5zniA-2yxxA:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zux YESW PROTEIN

(Bacillus
subtilis) 		no annotation 5 VAL A 302
GLY A 259
TYR A 215
ASP A 182
GLY A 183
 None
 1.26A 5zniA-2zuxA:
undetectable		 5zniA-2zuxA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bex TYPE III
PANTOTHENATE KINASE

(Thermotoga
maritima) 		PF03309
(Pan_kinase) 		5 VAL A 111
GLY A  58
VAL A  59
GLY A  56
PRO A  82
 None
 1.39A 5zniA-3bexA:
undetectable		 5zniA-3bexA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bvh FIBRINOGEN BETA
CHAIN

(Homo sapiens) 		PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha) 		5 GLY B 414
TYR B 422
VAL B 435
ASP B 398
GLY B 399
 None
 1.36A 5zniA-3bvhB:
undetectable		 5zniA-3bvhB:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bzw PUTATIVE LIPASE

(Bacteroides
thetaiotaomicron) 		PF13472
(Lipase_GDSL_2) 		5 GLY A  84
TYR A  68
VAL A  82
ASP A  53
PRO A  58
 None
None
None
ACT  A 301 (-3.5A)
None
 1.22A 5zniA-3bzwA:
2.3		 5zniA-3bzwA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efb PROBABLE SOR-OPERON
REGULATOR

(Shigella
flexneri) 		PF04198
(Sugar-bind) 		5 GLY A 192
TYR A 177
VAL A 190
GLY A 163
PRO A 165
 None
 1.08A 5zniA-3efbA:
undetectable		 5zniA-3efbA:
13.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3emv URIDINE
PHOSPHORYLASE,
PUTATIVE

(Plasmodium
vivax) 		PF01048
(PNP_UDP_1) 		8 VAL A  67
GLY A  94
TYR A 161
VAL A 182
GLU A 183
MET A 184
GLY A 208
PRO A 210
 None
 0.56A 5zniA-3emvA:
42.1		 5zniA-3emvA:
47.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fw8 RETICULINE OXIDASE

(Eschscholzia
californica) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 VAL A 360
GLY A 181
TYR A 456
MET A 415
GLY A 164
 None
None
FAD  A   1 (-4.6A)
None
FAD  A   1 (-3.4A)
 1.12A 5zniA-3fw8A:
undetectable		 5zniA-3fw8A:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h32 FIBRINOGEN BETA
CHAIN

(Homo sapiens) 		PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha) 		5 GLY B 414
TYR B 404
ASP B 433
GLY B 434
PRO B 412
 None
 1.32A 5zniA-3h32B:
undetectable		 5zniA-3h32B:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hka URONATE ISOMERASE

(Bacillus
halodurans) 		no annotation 5 GLY A 273
VAL A 265
ASP A 271
GLY A 270
PRO A 267
 None
 1.35A 5zniA-3hkaA:
undetectable		 5zniA-3hkaA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iau THREONINE DEAMINASE

(Solanum
lycopersicum) 		PF00291
(PALP) 		5 GLY A 240
TYR A 328
VAL A 241
ASP A 289
GLY A 290
 None
15P  A 368 (-4.7A)
None
None
None
 1.34A 5zniA-3iauA:
undetectable		 5zniA-3iauA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3koy D-ORNITHINE
AMINOMUTASE E
COMPONENT

(Acetoanaerobium
sticklandii) 		PF02310
(B12-binding)
PF09043
(Lys-AminoMut_A)
PF16554
(OAM_dimer) 		5 VAL A 243
GLY A 408
VAL A 405
ASP A 412
GLY A 423
 None
 1.38A 5zniA-3koyA:
undetectable		 5zniA-3koyA:
7.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oib ACYL-COA
DEHYDROGENASE

(Mycolicibacterium
smegmatis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 VAL A 261
GLY A  75
ASP A  86
GLY A  85
PRO A  77
 IOD  A 512 ( 4.1A)
None
None
None
None
 1.39A 5zniA-3oibA:
undetectable		 5zniA-3oibA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pow CALRETICULIN

(Homo sapiens) 		PF00262
(Calreticulin) 		5 VAL A 184
TYR A 172
VAL A 110
ASP A 135
GLY A 107
 None
 1.24A 5zniA-3powA:
undetectable		 5zniA-3powA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rg0 CALRETICULIN

(Mus musculus) 		PF00262
(Calreticulin) 		5 VAL A 184
TYR A 172
VAL A 110
ASP A 135
GLY A 107
 None
 1.21A 5zniA-3rg0A:
undetectable		 5zniA-3rg0A:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rxy NIF3 PROTEIN

(Sphaerobacter
thermophilus) 		no annotation 5 VAL A 198
GLY A  89
VAL A  86
GLU A  87
PRO A  91
 None
 1.38A 5zniA-3rxyA:
undetectable		 5zniA-3rxyA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s0x PEPTIDASE A24B, FLAK
DOMAIN PROTEIN

(Methanococcus
maripaludis) 		PF01478
(Peptidase_A24)
PF06847
(Arc_PepC_II) 		5 VAL A 610
VAL A 617
ASP A 721
GLY A 720
PRO A 717
 None
 1.27A 5zniA-3s0xA:
undetectable		 5zniA-3s0xA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3teu FIBCON

(-) 		PF00041
(fn3) 		5 VAL A  10
GLY A  65
VAL A  66
GLU A  67
GLY A  92
 None
 1.40A 5zniA-3teuA:
undetectable		 5zniA-3teuA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3teu FIBCON

(-) 		PF00041
(fn3) 		5 VAL A  70
GLY A  65
VAL A  66
GLU A  67
GLY A  91
 None
 1.31A 5zniA-3teuA:
undetectable		 5zniA-3teuA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsn 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE

(Campylobacter
jejuni) 		PF04166
(PdxA) 		5 GLY A  15
TYR A 350
GLU A  17
GLY A   9
PRO A 132
 None
 1.21A 5zniA-3tsnA:
2.4		 5zniA-3tsnA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9f TWO-COMPONENT SYSTEM
SENSOR HISTIDINE
KINASE/RESPONSE
REGULATOR, HYBRID
(ONE-COMPONENT
SYSTEM)

(Bacteroides
thetaiotaomicron) 		PF07494
(Reg_prop)
PF07495
(Y_Y_Y) 		5 TYR A 119
VAL A 149
GLU A 157
ASP A 160
GLY A 146
 None
 1.10A 5zniA-3v9fA:
undetectable		 5zniA-3v9fA:
8.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w3a V-TYPE ATP SYNTHASE
SUBUNIT F

(Thermus
thermophilus) 		PF01990
(ATP-synt_F) 		5 GLY H  40
VAL H  37
GLU H  38
GLY H  41
PRO H  69
 None
 1.40A 5zniA-3w3aH:
undetectable		 5zniA-3w3aH:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbh ALKALINE PHOSPHATASE

(Halomonas sp.
#593) 		PF00245
(Alk_phosphatase) 		5 VAL A 191
VAL A 166
GLU A 165
ASP A 171
GLY A 172
 None
 1.17A 5zniA-3wbhA:
undetectable		 5zniA-3wbhA:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zbm COPPER-CONTAINING
NITRITE REDUCTASE

(Ralstonia
pickettii) 		PF07732
(Cu-oxidase_3)
PF13442
(Cytochrome_CBB3) 		5 VAL A 399
GLY A 362
VAL A 366
ASP A 326
GLY A 325
 HEM  A1462 ( 4.7A)
None
None
None
None
 1.19A 5zniA-3zbmA:
undetectable		 5zniA-3zbmA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bht NADP-SPECIFIC
GLUTAMATE
DEHYDROGENASE

(Escherichia
coli) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 VAL A 143
GLY A 129
ASP A 168
GLY A  94
PRO A 165
 None
 1.40A 5zniA-4bhtA:
undetectable		 5zniA-4bhtA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cag POLYSACCHARIDE LYASE
FAMILY 11 PROTEIN

(Bacillus
licheniformis) 		PF01839
(FG-GAP) 		5 VAL A 272
GLY A 229
TYR A 185
ASP A 152
GLY A 153
 None
 1.36A 5zniA-4cagA:
undetectable		 5zniA-4cagA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d72 GLYCOSIDE HYDROLASE

(Streptococcus
pneumoniae) 		PF08306
(Glyco_hydro_98M)
PF08307
(Glyco_hydro_98C) 		5 GLY A 867
VAL A 878
GLU A 879
ASP A 842
GLY A 841
 None
 1.32A 5zniA-4d72A:
undetectable		 5zniA-4d72A:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ege DIPEPTIDASE PEPE

(Mycobacterium
ulcerans) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		5 VAL A 169
GLY A 250
VAL A 371
GLY A 224
PRO A 252
 None
 1.27A 5zniA-4egeA:
undetectable		 5zniA-4egeA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9i HYDROGENASE
MATURATION PROTEIN
HYPF

(Thermococcus
kodakarensis) 		PF00708
(Acylphosphatase)
PF00814
(Peptidase_M22)
PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		5 VAL A 484
GLY A 748
VAL A 751
ASP A 746
GLY A 745
 None
None
None
ZN  A1003 (-2.4A)
None
 1.13A 5zniA-4g9iA:
undetectable		 5zniA-4g9iA:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kg7 PEPTIDASE S8 AND
S53, SUBTILISIN,
KEXIN, SEDOLISIN

(Mycolicibacterium
smegmatis) 		PF00082
(Peptidase_S8) 		5 VAL A 203
GLY A 127
VAL A 130
ASP A 124
GLY A 125
 None
 1.36A 5zniA-4kg7A:
2.8		 5zniA-4kg7A:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nov XYLOSIDASE/ARABINOFU
RANOSIDASE XSA43E

(Butyrivibrio
proteoclasticus) 		PF04616
(Glyco_hydro_43) 		5 GLY A 253
TYR A 272
GLU A 251
ASP A 276
GLY A 275
 None
 1.31A 5zniA-4novA:
undetectable		 5zniA-4novA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4okr MICRONEMAL PROTEIN
MIC2

(Toxoplasma
gondii) 		PF00090
(TSP_1)
PF00092
(VWA) 		5 VAL A 117
GLY A 109
VAL A 113
ASP A 137
PRO A 107
 None
 1.19A 5zniA-4okrA:
3.2		 5zniA-4okrA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oku MICRONEMAL PROTEIN
MIC2

(Toxoplasma
gondii) 		PF00090
(TSP_1)
PF00092
(VWA) 		5 VAL A 117
GLY A 109
VAL A 113
ASP A 137
PRO A 107
 None
 1.17A 5zniA-4okuA:
3.0		 5zniA-4okuA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ou2 2-AMINOMUCONATE
6-SEMIALDEHYDE
DEHYDROGENASE

(Pseudomonas
fluorescens) 		PF00171
(Aldedh) 		5 GLY A 107
VAL A 103
GLU A 102
GLY A 342
PRO A 334
 None
 1.06A 5zniA-4ou2A:
1.6		 5zniA-4ou2A:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8x URICASE

(Bacillus
fastidiosus) 		PF01014
(Uricase) 		5 GLY A 205
TYR A 208
VAL A 265
GLU A 264
GLY A 165
 None
 1.26A 5zniA-4r8xA:
undetectable		 5zniA-4r8xA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u3w 2-AMINOMUCONATE
6-SEMIALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		5 GLY A 102
VAL A  98
GLU A  97
GLY A 337
PRO A 329
 None
 1.03A 5zniA-4u3wA:
undetectable		 5zniA-4u3wA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wlh KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 1

(Homo sapiens) 		PF00155
(Aminotran_1_2) 		5 VAL A 179
GLY A 243
VAL A 215
GLU A 214
GLY A 257
 None
None
LLP  A 247 ( 3.7A)
None
None
 1.33A 5zniA-4wlhA:
undetectable		 5zniA-4wlhA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wp0 KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 1

(Homo sapiens) 		PF00155
(Aminotran_1_2) 		5 VAL A 179
GLY A 243
VAL A 215
GLU A 214
GLY A 257
 None
None
LLP  A 247 ( 4.7A)
None
None
 1.35A 5zniA-4wp0A:
undetectable		 5zniA-4wp0A:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzz TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN

(Bordetella
bronchiseptica) 		PF03480
(DctP) 		5 GLY A  61
TYR A 263
VAL A  60
ASP A  65
GLY A  66
 None
 1.10A 5zniA-4yzzA:
undetectable		 5zniA-4yzzA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bq2 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Pseudomonas
aeruginosa) 		PF00275
(EPSP_synthase) 		5 VAL A  62
GLY A 226
VAL A  39
ASP A  36
GLY A 225
 None
 1.29A 5zniA-5bq2A:
undetectable		 5zniA-5bq2A:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bq2 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Pseudomonas
aeruginosa) 		PF00275
(EPSP_synthase) 		5 VAL A  62
GLY A 226
VAL A  39
GLU A  73
GLY A 225
 None
 1.30A 5zniA-5bq2A:
undetectable		 5zniA-5bq2A:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6s INTEGRIN ALPHA-L

(Homo sapiens) 		PF00092
(VWA)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		5 GLY A 328
VAL A 340
ASP A  87
GLY A 102
PRO A 120
 None
 1.34A 5zniA-5e6sA:
undetectable		 5zniA-5e6sA:
6.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eod COAGULATION FACTOR
XI

(Homo sapiens) 		PF00024
(PAN_1)
PF00089
(Trypsin) 		5 VAL A 572
GLY A 544
TYR A 590
VAL A 522
PRO A 587
 None
 1.39A 5zniA-5eodA:
undetectable		 5zniA-5eodA:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exe OXALATE
OXIDOREDUCTASE
SUBUNIT BETA

(Moorella
thermoacetica) 		PF02775
(TPP_enzyme_C) 		5 VAL C 181
GLY C 112
TYR C 218
ASP C 110
GLY C 109
 None
5SR  C 402 (-4.0A)
None
MG  C 403 ( 2.5A)
5SR  C 402 (-3.5A)
 1.30A 5zniA-5exeC:
undetectable		 5zniA-5exeC:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exe OXALATE
OXIDOREDUCTASE
SUBUNIT DELTA

(Moorella
thermoacetica) 		PF00037
(Fer4)
PF01558
(POR) 		5 VAL B 174
GLY B 163
VAL B 190
ASP B  27
GLY B 165
 None
 1.38A 5zniA-5exeB:
undetectable		 5zniA-5exeB:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f8z PLASMA KALLIKREIN
LIGHT CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		5 VAL A 210
GLY A 184
TYR A 228
VAL A 163
PRO A 225
 None
 1.35A 5zniA-5f8zA:
undetectable		 5zniA-5f8zA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f9o CH235.9 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H  68
GLY H   8
TYR H  94
MET H  81
GLY H  10
 None
 1.20A 5zniA-5f9oH:
undetectable		 5zniA-5f9oH:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ja1 ENTEROBACTIN
SYNTHASE COMPONENT F

(Escherichia
coli) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		5 VAL A 510
GLY A 529
VAL A 526
ASP A 506
GLY A 505
 None
 1.35A 5zniA-5ja1A:
undetectable		 5zniA-5ja1A:
4.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k51 HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE

(Trypanosoma
brucei) 		PF00156
(Pribosyltran) 		5 VAL A 191
GLY A 169
VAL A 185
ASP A 173
GLY A 171
 None
 1.40A 5zniA-5k51A:
undetectable		 5zniA-5k51A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m2s PUTATIVE
CELLULOSOMAL
SCAFFOLDIN PROTEIN

(Ruminococcus
flavefaciens) 		no annotation 5 VAL A  42
GLY A 136
VAL A 112
ASP A  12
GLY A  14
 None
 1.22A 5zniA-5m2sA:
undetectable		 5zniA-5m2sA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrw POTASSIUM-TRANSPORTI
NG ATPASE
POTASSIUM-BINDING
SUBUNIT
POTASSIUM-TRANSPORTI
NG ATPASE KDPC
SUBUNIT

(Escherichia
coli;
Escherichia
coli) 		PF03814
(KdpA)
PF02669
(KdpC) 		5 VAL A 295
GLY A 328
VAL A 329
MET A 299
GLY C 172
 None
 1.30A 5zniA-5mrwA:
undetectable		 5zniA-5mrwA:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nij VACUOLAR-PROCESSING
ENZYME GAMMA-ISOZYME

(Arabidopsis
thaliana) 		no annotation 5 VAL A 383
TYR A 366
GLU A 378
GLY A 372
PRO A 370
 None
 1.30A 5zniA-5nijA:
2.0		 5zniA-5nijA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5no5 ABYA5

(Verrucosispora) 		no annotation 5 VAL A 259
GLY A 332
TYR A  30
VAL A 330
PRO A 334
 None
 1.17A 5zniA-5no5A:
undetectable		 5zniA-5no5A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tem 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE

(Vibrio
vulnificus) 		no annotation 5 VAL C   6
GLY C  42
VAL C  41
GLU C  34
ASP C  44
 None
None
None
NAD  C1001 (-2.9A)
None
 1.35A 5zniA-5temC:
2.6		 5zniA-5temC:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v7o NOSK

(Streptomyces
actuosus) 		PF12697
(Abhydrolase_6) 		5 VAL A 248
GLY A 204
VAL A 228
ASP A 239
GLY A 233
 None
 1.37A 5zniA-5v7oA:
undetectable		 5zniA-5v7oA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wt4 CYSTEINE DESULFURASE
ISCS

(Helicobacter
pylori) 		no annotation 5 VAL A 258
GLY A 249
VAL A  19
GLU A 252
PRO A 210
 None
 1.29A 5zniA-5wt4A:
undetectable		 5zniA-5wt4A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxu RIBOSOMAL PROTEIN
US19
RIBOSOMAL PROTEIN
US13

(Toxoplasma
gondii;
Toxoplasma
gondii) 		PF00203
(Ribosomal_S19)
PF00416
(Ribosomal_S13) 		5 GLY P  24
VAL P  25
GLU P  26
ASP S  94
GLY S  95
 None
 1.39A 5zniA-5xxuP:
undetectable		 5zniA-5xxuP:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyj ACETYL-COA
ACETYLTRANSFERASE

(Saccharomyces
cerevisiae) 		no annotation 5 VAL B  72
VAL B 205
ASP B 256
GLY B  16
PRO B  14
 None
 1.37A 5zniA-5xyjB:
undetectable		 5zniA-5xyjB:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6az1 RIBOSOMAL PROTEIN
S4E

(Leishmania
donovani) 		no annotation 5 VAL E 234
GLY E 187
VAL E 180
ASP E 101
GLY E 104
 None
 1.37A 5zniA-6az1E:
undetectable		 5zniA-6az1E:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b82 CYTOCHROME P450,
FAMILY 17, SUBFAMILY
A, POLYPEPTIDE 1

(Danio rerio) 		no annotation 5 GLY A 312
TYR A 214
VAL A 315
GLU A 316
GLY A 308
 AER  A 602 ( 3.7A)
None
None
None
None
 1.13A 5zniA-6b82A:
undetectable		 5zniA-6b82A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6blg DTDP-4-AMINO-4,6-DID
EOXYGALACTOSE
TRANSAMINASE

(Klebsiella
pneumoniae) 		no annotation 5 VAL A 124
GLY A  92
VAL A  89
ASP A  72
GLY A  71
 None
SO4  A 406 ( 4.2A)
None
None
None
 1.36A 5zniA-6blgA:
undetectable		 5zniA-6blgA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0e ISOCITRATE
DEHYDROGENASE

(Legionella
pneumophila) 		no annotation 5 VAL A  55
GLY A  44
VAL A  47
MET A  51
GLY A  40
 None
 1.39A 5zniA-6c0eA:
undetectable		 5zniA-6c0eA:
28.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 5 GLY A 141
TYR A 147
GLU A 143
ASP A 191
GLY A 192
 None
 1.19A 5zniA-6c9dA:
2.0		 5zniA-6c9dA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fpe TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN TSAB

(Thermotoga
maritima) 		no annotation 5 VAL A  40
GLY A  59
VAL A  58
ASP A   7
GLY A  61
 None
 1.34A 5zniA-6fpeA:
undetectable		 5zniA-6fpeA:
22.35