SIMILAR PATTERNS OF AMINO ACIDS FOR 5ZNC_A_QI9A301_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE

(Escherichia
coli) 		PF01048
(PNP_UDP_1) 		5 SER A  90
GLY A  92
VAL A 178
GLU A 179
MET A 180
 PO4  A 309 ( 2.7A)
2FA  A 306 (-3.5A)
2FA  A 306 (-4.8A)
2FA  A 306 (-4.7A)
2FA  A 306 (-3.8A)
 0.38A 5zncA-1pk9A:
17.4		 5zncA-1pk9A:
28.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zos 5'-METHYLTHIOADENOSI
NE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE

(Streptococcus
pneumoniae) 		PF01048
(PNP_UDP_1) 		5 SER A  76
GLY A  78
VAL A 171
GLU A 172
MET A 173
 MTM  A 301 (-3.1A)
MTM  A 301 (-3.6A)
None
None
MTM  A 301 (-3.5A)
 0.58A 5zncA-1zosA:
21.6		 5zncA-1zosA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zos 5'-METHYLTHIOADENOSI
NE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE

(Streptococcus
pneumoniae) 		PF01048
(PNP_UDP_1) 		5 SER A  76
VAL A 171
GLU A 172
MET A 173
ASP A 197
 MTM  A 301 (-3.1A)
None
None
MTM  A 301 (-3.5A)
MTM  A 301 (-2.9A)
 1.07A 5zncA-1zosA:
21.6		 5zncA-1zosA:
23.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2bsx PURINE NUCLEOSIDE
PHOSPHORYLASE

(Plasmodium
falciparum) 		PF01048
(PNP_UDP_1) 		5 VAL A  66
GLY A  93
VAL A 181
GLU A 182
ASP A 206
 NOS  A1248 ( 3.8A)
NOS  A1248 (-4.0A)
NOS  A1248 ( 4.4A)
None
NOS  A1248 (-4.1A)
 1.43A 5zncA-2bsxA:
42.8		 5zncA-2bsxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2bsx PURINE NUCLEOSIDE
PHOSPHORYLASE

(Plasmodium
falciparum) 		PF01048
(PNP_UDP_1) 		8 VAL A  66
SER A  91
GLY A  93
TYR A 160
VAL A 181
GLU A 182
MET A 183
TRP A 212
 NOS  A1248 ( 3.8A)
NOS  A1248 (-2.9A)
NOS  A1248 (-4.0A)
NOS  A1248 (-4.7A)
NOS  A1248 ( 4.4A)
None
NOS  A1248 (-3.4A)
NOS  A1248 (-4.6A)
 0.31A 5zncA-2bsxA:
42.8		 5zncA-2bsxA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bl6 5'-METHYLTHIOADENOSI
NE
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE

(Staphylococcus
aureus) 		PF01048
(PNP_UDP_1) 		5 SER A  75
GLY A  77
VAL A 170
GLU A 171
MET A 172
 FMC  A 229 (-3.0A)
FMC  A 229 (-3.6A)
FMC  A 229 ( 4.7A)
FMC  A 229 (-4.7A)
FMC  A 229 (-3.5A)
 0.31A 5zncA-3bl6A:
24.3		 5zncA-3bl6A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bl6 5'-METHYLTHIOADENOSI
NE
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE

(Staphylococcus
aureus) 		PF01048
(PNP_UDP_1) 		5 SER A  75
VAL A 170
GLU A 171
MET A 172
ASP A 196
 FMC  A 229 (-3.0A)
FMC  A 229 ( 4.7A)
FMC  A 229 (-4.7A)
FMC  A 229 (-3.5A)
FMC  A 229 (-3.0A)
 0.97A 5zncA-3bl6A:
24.3		 5zncA-3bl6A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dp9 MTA/SAH NUCLEOSIDASE

(Vibrio cholerae) 		PF01048
(PNP_UDP_1) 		5 SER A  76
GLY A  78
VAL A 172
GLU A 173
MET A 174
 BIG  A 301 (-3.3A)
BIG  A 301 (-3.7A)
BIG  A 301 (-4.9A)
None
BIG  A 301 (-3.6A)
 0.48A 5zncA-3dp9A:
23.7		 5zncA-3dp9A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dp9 MTA/SAH NUCLEOSIDASE

(Vibrio cholerae) 		PF01048
(PNP_UDP_1) 		5 SER A  76
VAL A 172
GLU A 173
MET A 174
ASP A 198
 BIG  A 301 (-3.3A)
BIG  A 301 (-4.9A)
None
BIG  A 301 (-3.6A)
BIG  A 301 (-2.9A)
 1.03A 5zncA-3dp9A:
23.7		 5zncA-3dp9A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE

(Neisseria
meningitidis) 		PF01048
(PNP_UDP_1) 		5 SER A  79
GLY A  81
VAL A 175
GLU A 176
MET A 177
 MTM  A 234 (-3.1A)
MTM  A 234 (-3.9A)
MTM  A 234 ( 4.9A)
MTM  A 234 (-4.6A)
MTM  A 234 (-3.8A)
 0.38A 5zncA-3eeiA:
23.5		 5zncA-3eeiA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE

(Neisseria
meningitidis) 		PF01048
(PNP_UDP_1) 		5 SER A  79
VAL A 175
GLU A 176
MET A 177
ASP A 201
 MTM  A 234 (-3.1A)
MTM  A 234 ( 4.9A)
MTM  A 234 (-4.6A)
MTM  A 234 (-3.8A)
MTM  A 234 (-3.0A)
 1.03A 5zncA-3eeiA:
23.5		 5zncA-3eeiA:
23.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3emv URIDINE
PHOSPHORYLASE,
PUTATIVE

(Plasmodium
vivax) 		PF01048
(PNP_UDP_1) 		6 VAL A  67
GLY A  94
VAL A 182
GLU A 183
MET A 184
ASP A 207
 None
 1.26A 5zncA-3emvA:
42.4		 5zncA-3emvA:
81.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3emv URIDINE
PHOSPHORYLASE,
PUTATIVE

(Plasmodium
vivax) 		PF01048
(PNP_UDP_1) 		7 VAL A  67
SER A  92
GLY A  94
TYR A 161
VAL A 182
GLU A 183
MET A 184
 None
SO4  A 254 (-3.2A)
None
None
None
None
None
 0.19A 5zncA-3emvA:
42.4		 5zncA-3emvA:
81.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcz POLYPROTEIN

(Yokose virus) 		PF01728
(FtsJ) 		5 VAL A  71
GLY A  58
TYR A 221
MET A  65
ASP A 146
 None
SAM  A4633 (-3.5A)
None
None
SAM  A4633 (-3.7A)
 1.34A 5zncA-3gczA:
undetectable		 5zncA-3gczA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o4v MTA/SAH NUCLEOSIDASE

(Escherichia
coli) 		PF01048
(PNP_UDP_1) 		5 SER A  76
GLY A  78
VAL A 171
GLU A 172
MET A 173
 4CT  A 233 (-3.2A)
4CT  A 233 (-3.8A)
4CT  A 233 ( 4.9A)
None
4CT  A 233 (-3.6A)
 0.35A 5zncA-3o4vA:
23.6		 5zncA-3o4vA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o4v MTA/SAH NUCLEOSIDASE

(Escherichia
coli) 		PF01048
(PNP_UDP_1) 		5 SER A  76
VAL A 171
GLU A 172
MET A 173
ASP A 197
 4CT  A 233 (-3.2A)
4CT  A 233 ( 4.9A)
None
4CT  A 233 (-3.6A)
4CT  A 233 (-2.9A)
 1.03A 5zncA-3o4vA:
23.6		 5zncA-3o4vA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3of3 PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE 1

(Vibrio cholerae) 		PF01048
(PNP_UDP_1) 		5 SER A 104
GLY A 106
VAL A 192
GLU A 193
MET A 194
 PO4  A 501 ( 2.7A)
DIH  A 500 (-4.0A)
DIH  A 500 (-4.8A)
None
DIH  A 500 (-3.8A)
 0.33A 5zncA-3of3A:
17.6		 5zncA-3of3A:
27.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tl6 PURINE NUCLEOSIDE
PHOSPHORYLASE

(Entamoeba
histolytica) 		PF01048
(PNP_UDP_1) 		5 SER A  95
GLY A  97
VAL A 182
GLU A 183
MET A 184
 SO4  A 239 (-3.4A)
None
None
None
None
 0.29A 5zncA-3tl6A:
31.6		 5zncA-3tl6A:
28.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9a ESTERASE/LIPASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 VAL A 287
GLY A 147
TYR A  72
VAL A 150
ASP A 143
 None
 1.30A 5zncA-3v9aA:
2.8		 5zncA-3v9aA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Bacillus
subtilis) 		PF01048
(PNP_UDP_1) 		5 SER A  90
GLY A  92
VAL A 177
GLU A 178
MET A 179
 ADE  A 301 (-3.4A)
ADE  A 301 (-3.5A)
ADE  A 301 (-4.4A)
None
ADE  A 301 ( 4.3A)
 0.40A 5zncA-4daoA:
32.0		 5zncA-4daoA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5a PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
F, MITOCHONDRIAL

(Homo sapiens) 		PF00160
(Pro_isomerase) 		5 VAL X 180
SER X 186
GLY X 188
VAL X  98
GLU X 185
 None
 1.30A 5zncA-4j5aX:
undetectable		 5zncA-4j5aX:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcp PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Brugia malayi) 		PF00160
(Pro_isomerase) 		5 VAL A 145
SER A 151
GLY A 153
VAL A  63
GLU A 150
 None
 1.28A 5zncA-4jcpA:
undetectable		 5zncA-4jcpA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ldn PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Aliivibrio
fischeri) 		PF01048
(PNP_UDP_1) 		5 SER A  91
GLY A  93
VAL A 179
GLU A 180
MET A 181
 PO4  A 301 (-3.0A)
None
None
None
None
 0.49A 5zncA-4ldnA:
32.2		 5zncA-4ldnA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pr3 5'-METHYLTHIOADENOSI
NE NUCLEOSIDASE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE

(Brucella
melitensis) 		PF01048
(PNP_UDP_1) 		5 VAL A  34
SER A  65
GLY A  67
VAL A 142
MET A 144
 None
ADE  A 501 (-3.5A)
ADE  A 501 (-3.7A)
ADE  A 501 (-4.7A)
ADE  A 501 (-4.0A)
 0.60A 5zncA-4pr3A:
14.9		 5zncA-4pr3A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qez 5'-METHYLTHIOADENOSI
NE/S-ADENOSYLHOMOCYS
TEINE NUCLEOSIDASE

(Bacillus
anthracis) 		no annotation 5 SER B  76
GLY B  78
VAL B 172
GLU B 173
MET B 174
 TRS  B 302 (-2.8A)
ADE  B 301 (-3.2A)
None
TRS  B 302 ( 4.8A)
TRS  B 302 (-4.2A)
 0.57A 5zncA-4qezB:
22.3		 5zncA-4qezB:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dk6 5'-METHYLTHIOADENOSI
NE/S-ADENOSYLHOMOCYS
TEINE NUCLEOSIDASE

(Colwellia
psychrerythraea) 		PF01048
(PNP_UDP_1) 		5 SER A  76
GLY A  78
VAL A 177
GLU A 178
MET A 179
 ADE  A 302 ( 3.7A)
ADE  A 302 (-3.6A)
ADE  A 302 (-4.6A)
None
ADE  A 302 (-4.1A)
 0.39A 5zncA-5dk6A:
22.7		 5zncA-5dk6A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dk6 5'-METHYLTHIOADENOSI
NE/S-ADENOSYLHOMOCYS
TEINE NUCLEOSIDASE

(Colwellia
psychrerythraea) 		PF01048
(PNP_UDP_1) 		5 SER A  76
VAL A 177
GLU A 178
MET A 179
ASP A 203
 ADE  A 302 ( 3.7A)
ADE  A 302 (-4.6A)
None
ADE  A 302 (-4.1A)
ADE  A 302 (-2.9A)
 1.02A 5zncA-5dk6A:
22.7		 5zncA-5dk6A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hke BILE SALT HYDROLASE

(Lactobacillus
salivarius) 		PF02275
(CBAH) 		5 GLY A  53
TYR A 274
VAL A  28
GLU A  27
ASP A  66
 None
 1.12A 5zncA-5hkeA:
undetectable		 5zncA-5hkeA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ue1 5'-METHYLTHIOADENOSI
NE/S-ADENOSYLHOMOCYS
TEINE NUCLEOSIDASE

(Aliivibrio
fischeri) 		PF01048
(PNP_UDP_1) 		5 SER A  76
GLY A  78
VAL A 172
GLU A 173
MET A 174
 TRS  A 302 (-2.8A)
9DA  A 301 (-3.5A)
None
TRS  A 302 ( 4.6A)
TRS  A 302 (-3.9A)
 0.55A 5zncA-5ue1A:
23.9		 5zncA-5ue1A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ue1 5'-METHYLTHIOADENOSI
NE/S-ADENOSYLHOMOCYS
TEINE NUCLEOSIDASE

(Aliivibrio
fischeri) 		PF01048
(PNP_UDP_1) 		5 SER A  76
VAL A 172
GLU A 173
MET A 174
ASP A 198
 TRS  A 302 (-2.8A)
None
TRS  A 302 ( 4.6A)
TRS  A 302 (-3.9A)
9DA  A 301 (-2.8A)
 1.02A 5zncA-5ue1A:
23.9		 5zncA-5ue1A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xrt -

(-) 		no annotation 5 VAL A 130
SER A 247
GLY A 200
TYR A 195
GLU A 163
 None
None
None
None
NAG  A 511 (-4.1A)
 0.97A 5zncA-5xrtA:
undetectable		 5zncA-5xrtA:
undetectable