SIMILAR PATTERNS OF AMINO ACIDS FOR 5ZMQ_K_PACK1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aa2 BETA-SPECTRIN

(Homo sapiens) 		PF00307
(CH) 		3 ALA A  39
VAL A  99
TYR A 102
 None
 0.60A 5zmqH-1aa2A:
undetectable		 5zmqH-1aa2A:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1awb MYO-INOSITOL
MONOPHOSPHATASE

(Homo sapiens) 		PF00459
(Inositol_P) 		3 ALA A 224
VAL A 160
TYR A 211
 None
 0.70A 5zmqH-1awbA:
0.2		 5zmqH-1awbA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cli PROTEIN
(PHOSPHORIBOSYL-AMIN
OIMIDAZOLE
SYNTHETASE)

(Escherichia
coli) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		3 ALA A 121
VAL A 156
TYR A 109
 None
 0.64A 5zmqH-1cliA:
0.0		 5zmqH-1cliA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e9y UREASE SUBUNIT BETA

(Helicobacter
pylori) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		3 ALA B 213
VAL B 237
TYR B 241
 None
 0.59A 5zmqH-1e9yB:
0.0		 5zmqH-1e9yB:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ek6 UDP-GALACTOSE
4-EPIMERASE

(Homo sapiens) 		PF16363
(GDP_Man_Dehyd) 		3 ALA A 133
VAL A  94
TYR A 157
 UPG  A 401 ( 3.7A)
None
UPG  A 401 ( 4.4A)
 0.70A 5zmqH-1ek6A:
0.0		 5zmqH-1ek6A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fta FRUCTOSE-1,6-BISPHOS
PHATASE

(Homo sapiens) 		PF00316
(FBPase) 		3 ALA A  47
VAL A 132
TYR A 167
 None
 0.72A 5zmqH-1ftaA:
0.0		 5zmqH-1ftaA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g3m ESTROGEN
SULFOTRANSFERASE

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		3 ALA A 135
VAL A 175
TYR A  45
 None
 0.71A 5zmqH-1g3mA:
0.0		 5zmqH-1g3mA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ghs 1,3-BETA-GLUCANASE

(Hordeum vulgare) 		PF00332
(Glyco_hydro_17) 		3 ALA A 212
VAL A 193
TYR A 202
 None
 0.69A 5zmqH-1ghsA:
0.0		 5zmqH-1ghsA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1grw MAJOR SPERM PROTEIN
31/40/142

(Caenorhabditis
elegans) 		PF00635
(Motile_Sperm) 		3 ALA A  67
VAL A  91
TYR A  43
 None
 0.72A 5zmqH-1grwA:
0.0		 5zmqH-1grwA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gud D-ALLOSE-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli) 		PF13407
(Peripla_BP_4) 		3 ALA A 119
VAL A 224
TYR A 198
 None
 0.71A 5zmqH-1gudA:
0.0		 5zmqH-1gudA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i60 IOLI PROTEIN

(Bacillus
subtilis) 		PF01261
(AP_endonuc_2) 		3 ALA A 233
VAL A 272
TYR A 275
 None
 0.69A 5zmqH-1i60A:
undetectable		 5zmqH-1i60A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i6q LACTOFERRIN

(Camelus
dromedarius) 		PF00405
(Transferrin) 		3 ALA A 148
VAL A 161
TYR A 166
 None
 0.71A 5zmqH-1i6qA:
undetectable		 5zmqH-1i6qA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iok CHAPERONIN 60

(Paracoccus
denitrificans) 		PF00118
(Cpn60_TCP1) 		3 ALA A 481
VAL A 469
TYR A 486
 None
 0.64A 5zmqH-1iokA:
undetectable		 5zmqH-1iokA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ize ASPARTIC PROTEINASE

(Aspergillus
oryzae) 		PF00026
(Asp) 		3 ALA A 101
VAL A 144
TYR A  97
 None
 0.64A 5zmqH-1izeA:
undetectable		 5zmqH-1izeA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j77 HEMO

(Neisseria
meningitidis) 		PF01126
(Heme_oxygenase) 		3 ALA A  55
VAL A  81
TYR A  78
 None
 0.62A 5zmqH-1j77A:
undetectable		 5zmqH-1j77A:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kny KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE

(Staphylococcus
aureus) 		PF07827
(KNTase_C) 		3 ALA A  89
VAL A  56
TYR A  80
 None
 0.69A 5zmqH-1knyA:
undetectable		 5zmqH-1knyA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lgy TRIACYLGLYCEROL
LIPASE

(Rhizopus niveus) 		PF01764
(Lipase_3) 		3 ALA A 151
VAL A 119
TYR A 116
 None
 0.65A 5zmqH-1lgyA:
undetectable		 5zmqH-1lgyA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1li7 CYSTEINYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF01406
(tRNA-synt_1e)
PF09190
(DALR_2) 		3 ALA A 211
VAL A  64
TYR A  26
 None
 0.61A 5zmqH-1li7A:
undetectable		 5zmqH-1li7A:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrk UDP-GLUCOSE
4-EPIMERASE

(Escherichia
coli) 		PF16363
(GDP_Man_Dehyd) 		3 ALA A 125
VAL A  86
TYR A 149
 None
UD1  A 341 (-4.3A)
NAD  A 340 (-4.6A)
 0.63A 5zmqH-1lrkA:
undetectable		 5zmqH-1lrkA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1naa CELLOBIOSE
DEHYDROGENASE

(Phanerochaete
chrysosporium) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		3 ALA A 745
VAL A 242
TYR A 219
 None
 0.67A 5zmqH-1naaA:
undetectable		 5zmqH-1naaA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nh9 DNA-BINDING PROTEIN
ALBA

(Methanocaldococcus
jannaschii) 		PF01918
(Alba) 		3 ALA A  33
VAL A  12
TYR A  15
 None
 0.66A 5zmqH-1nh9A:
undetectable		 5zmqH-1nh9A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p3w CYSTEINE DESULFURASE

(Escherichia
coli) 		no annotation 3 ALA B 165
VAL B 148
TYR B 177
 None
 0.52A 5zmqH-1p3wB:
undetectable		 5zmqH-1p3wB:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pdz ENOLASE

(Homarus
gammarus) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		3 ALA A 174
VAL A 187
TYR A 235
 None
 0.67A 5zmqH-1pdzA:
undetectable		 5zmqH-1pdzA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q33 ADP-RIBOSE
PYROPHOSPHATASE

(Homo sapiens) 		PF00293
(NUDIX) 		3 ALA A 278
VAL A 269
TYR A 268
 None
BGC  A 400 (-4.5A)
None
 0.68A 5zmqH-1q33A:
undetectable		 5zmqH-1q33A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rzr GLUCOSE-RESISTANCE
AMYLASE REGULATOR

(Bacillus
megaterium) 		no annotation 3 ALA G 242
VAL G 211
TYR G 215
 None
 0.62A 5zmqH-1rzrG:
undetectable		 5zmqH-1rzrG:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1shk SHIKIMATE KINASE

(Dickeya
chrysanthemi) 		PF01202
(SKI) 		3 ALA A 141
VAL A   8
TYR A  99
 None
 0.63A 5zmqH-1shkA:
undetectable		 5zmqH-1shkA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sjp 60 KDA CHAPERONIN 2

(Mycobacterium
tuberculosis) 		PF00118
(Cpn60_TCP1) 		3 ALA A 476
VAL A 465
TYR A 481
 None
 0.69A 5zmqH-1sjpA:
undetectable		 5zmqH-1sjpA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tc1 PROTEIN
(HYPOXANTHINE
PHOSPHORIBOSYLTRANSF
ERASE)

(Trypanosoma
cruzi) 		PF00156
(Pribosyltran) 		3 ALA A  30
VAL A 138
TYR A 155
 None
 0.70A 5zmqH-1tc1A:
undetectable		 5zmqH-1tc1A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2

(Streptomyces
coelicolor) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 ALA B 358
VAL B 226
TYR B 215
 None
 0.70A 5zmqH-1tqyB:
undetectable		 5zmqH-1tqyB:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tzm 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE

(Pseudomonas sp.
ACP) 		PF00291
(PALP) 		3 ALA A 278
VAL A 194
TYR A 319
 None
 0.66A 5zmqH-1tzmA:
undetectable		 5zmqH-1tzmA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vp4 AMINOTRANSFERASE,
PUTATIVE

(Thermotoga
maritima) 		PF00155
(Aminotran_1_2) 		3 ALA A 137
VAL A 213
TYR A 180
 None
 0.61A 5zmqH-1vp4A:
undetectable		 5zmqH-1vp4A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcu NON-CATALYTIC
PROTEIN 1

(Piromyces equi) 		no annotation 3 ALA A  89
VAL A 108
TYR A 112
 None
 0.58A 5zmqH-1wcuA:
undetectable		 5zmqH-1wcuA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wst MULTIPLE SUBSTRATE
AMINOTRANSFERASE

(Thermococcus
profundus) 		PF00155
(Aminotran_1_2) 		3 ALA A 146
VAL A 220
TYR A 187
 None
 0.63A 5zmqH-1wstA:
undetectable		 5zmqH-1wstA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyq SPECTRIN BETA CHAIN,
BRAIN 2

(Homo sapiens) 		PF00307
(CH) 		3 ALA A  43
VAL A 103
TYR A 106
 None
 0.61A 5zmqH-1wyqA:
undetectable		 5zmqH-1wyqA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x0m AMINOTRANSFERASE II
HOMOLOGUE

(Pyrococcus
horikoshii) 		PF00155
(Aminotran_1_2) 		3 ALA A 160
VAL A 234
TYR A 201
 None
 0.62A 5zmqH-1x0mA:
undetectable		 5zmqH-1x0mA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x75 DNA GYRASE SUBUNIT A

(Escherichia
coli) 		PF00521
(DNA_topoisoIV) 		3 ALA A 384
VAL A 443
TYR A 448
 None
 0.58A 5zmqH-1x75A:
undetectable		 5zmqH-1x75A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xov PLY PROTEIN

(Listeria virus
PSA) 		PF01520
(Amidase_3) 		3 ALA A 153
VAL A  30
TYR A 160
 None
 0.55A 5zmqH-1xovA:
undetectable		 5zmqH-1xovA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xvy SFUA

(Yersinia
enterocolitica) 		PF13343
(SBP_bac_6) 		3 ALA A 110
VAL A 106
TYR A 107
 None
 0.70A 5zmqH-1xvyA:
undetectable		 5zmqH-1xvyA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ysq HTH-TYPE
TRANSCRIPTIONAL
REGULATOR YIAJ

(Escherichia
coli) 		PF01614
(IclR) 		3 ALA A  66
VAL A 142
TYR A  71
 PO4  A 301 (-3.6A)
PO4  A 303 (-4.0A)
PO4  A 303 (-4.4A)
 0.60A 5zmqH-1ysqA:
undetectable		 5zmqH-1ysqA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae) 		PF01263
(Aldose_epim)
PF16363
(GDP_Man_Dehyd) 		3 ALA A 136
VAL A  97
TYR A 163
 UPG  A 704 (-3.6A)
None
NAD  A 703 ( 4.6A)
 0.62A 5zmqH-1z45A:
undetectable		 5zmqH-1z45A:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z82 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Thermotoga
maritima) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		3 ALA A 276
VAL A 298
TYR A 295
 None
 0.61A 5zmqH-1z82A:
undetectable		 5zmqH-1z82A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z9d URIDYLATE KINASE

(Streptococcus
pyogenes) 		PF00696
(AA_kinase) 		3 ALA A 156
VAL A 229
TYR A   7
 None
 0.66A 5zmqH-1z9dA:
undetectable		 5zmqH-1z9dA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a1f URIDYLATE KINASE

(Haemophilus
influenzae) 		PF00696
(AA_kinase) 		3 ALA A 155
VAL A 227
TYR A   6
 None
 0.66A 5zmqH-2a1fA:
undetectable		 5zmqH-2a1fA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		3 ALA A  40
VAL A   9
TYR A  13
 GOL  A3001 (-3.5A)
None
None
 0.65A 5zmqH-2a2aA:
1.1		 5zmqH-2a2aA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2akz GAMMA ENOLASE

(Homo sapiens) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		3 ALA A 174
VAL A 187
TYR A 235
 None
 0.69A 5zmqH-2akzA:
undetectable		 5zmqH-2akzA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b1p MITOGEN-ACTIVATED
PROTEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		3 ALA A  91
VAL A  60
TYR A  64
 AIZ  A 501 (-3.4A)
None
None
 0.66A 5zmqH-2b1pA:
undetectable		 5zmqH-2b1pA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bbe HYPOTHETICAL PROTEIN
SO0527

(Shewanella
oneidensis) 		PF03992
(ABM) 		3 ALA A  35
VAL A  90
TYR A  86
 None
 0.69A 5zmqH-2bbeA:
undetectable		 5zmqH-2bbeA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bji INOSITOL-1(OR
4)-MONOPHOSPHATASE

(Bos taurus) 		PF00459
(Inositol_P) 		3 ALA A1197
VAL A1160
TYR A1211
 None
 0.72A 5zmqH-2bjiA:
undetectable		 5zmqH-2bjiA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bl5 MGC83862 PROTEIN

(Xenopus laevis) 		PF00013
(KH_1) 		3 ALA A 102
VAL A   8
TYR A  13
 None
 0.56A 5zmqH-2bl5A:
undetectable		 5zmqH-2bl5A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buj SERINE/THREONINE-PRO
TEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		3 ALA A  82
VAL A  37
TYR A  46
 None
 0.70A 5zmqH-2bujA:
1.6		 5zmqH-2bujA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c20 UDP-GLUCOSE
4-EPIMERASE

(Bacillus
anthracis) 		PF01370
(Epimerase) 		3 ALA A 119
VAL A  80
TYR A 142
 None
 0.41A 5zmqH-2c20A:
undetectable		 5zmqH-2c20A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c6w PENICILLIN-BINDING
PROTEIN 1A

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		3 ALA B 343
VAL B 279
TYR B 501
 None
 0.71A 5zmqH-2c6wB:
undetectable		 5zmqH-2c6wB:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ct8 METHIONYL-TRNA
SYNTHETASE

(Aquifex
aeolicus) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF09334
(tRNA-synt_1g) 		3 ALA A 338
VAL A 309
TYR A 313
 None
 0.45A 5zmqH-2ct8A:
undetectable		 5zmqH-2ct8A:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0o DIOL
DEHYDRATASE-REACTIVA
TING FACTOR LARGE
SUBUNIT
DIOL
DEHYDRATASE-REACTIVA
TING FACTOR SMALL
SUBUNIT

(Klebsiella
oxytoca;
Klebsiella
oxytoca) 		PF08841
(DDR)
PF02288
(Dehydratase_MU) 		3 ALA A 495
VAL B  61
TYR B  74
 None
 0.71A 5zmqH-2d0oA:
undetectable		 5zmqH-2d0oA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ej0 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF01063
(Aminotran_4) 		3 ALA A 258
VAL A 224
TYR A 287
 None
 0.63A 5zmqH-2ej0A:
undetectable		 5zmqH-2ej0A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2et6 (3R)-HYDROXYACYL-COA
DEHYDROGENASE

(Candida
tropicalis) 		PF00106
(adh_short) 		3 ALA A 347
VAL A 389
TYR A 393
 None
 0.31A 5zmqH-2et6A:
undetectable		 5zmqH-2et6A:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6h MYOSIN-2

(Saccharomyces
cerevisiae) 		PF01843
(DIL) 		3 ALA X 170
VAL X 132
TYR X 129
 None
 0.39A 5zmqH-2f6hX:
undetectable		 5zmqH-2f6hX:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6x (S)-3-O-GERANYLGERAN
YLGLYCERYL PHOSPHATE
SYNTHASE

(Archaeoglobus
fulgidus) 		PF01884
(PcrB) 		3 ALA A1025
VAL A1054
TYR A1057
 None
 0.68A 5zmqH-2f6xA:
undetectable		 5zmqH-2f6xA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fym ENOLASE

(Escherichia
coli) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		3 ALA A 175
VAL A 188
TYR A 234
 None
 0.72A 5zmqH-2fymA:
undetectable		 5zmqH-2fymA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fym ENOLASE

(Escherichia
coli) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		3 ALA A 175
VAL A 229
TYR A 234
 None
 0.71A 5zmqH-2fymA:
undetectable		 5zmqH-2fymA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g80 PROTEIN UTR4

(Saccharomyces
cerevisiae) 		no annotation 3 ALA A 218
VAL A 114
TYR A 115
 None
PE4  A 501 (-4.4A)
PE4  A 501 (-4.4A)
 0.68A 5zmqH-2g80A:
undetectable		 5zmqH-2g80A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		3 ALA A 256
VAL A 292
TYR A 326
 None
 0.58A 5zmqH-2h8hA:
undetectable		 5zmqH-2h8hA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ibp CITRATE SYNTHASE

(Pyrobaculum
aerophilum) 		PF00285
(Citrate_synt) 		3 ALA A 151
VAL A 117
TYR A 234
 None
 0.64A 5zmqH-2ibpA:
undetectable		 5zmqH-2ibpA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ip1 TRYPTOPHANYL-TRNA
SYNTHETASE

(Saccharomyces
cerevisiae) 		PF00579
(tRNA-synt_1b) 		3 ALA A 285
VAL A 192
TYR A 159
 None
 0.69A 5zmqH-2ip1A:
undetectable		 5zmqH-2ip1A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j6l ALDEHYDE
DEHYDROGENASE FAMILY
7 MEMBER A1

(Homo sapiens) 		PF00171
(Aldedh) 		3 ALA A  93
VAL A 171
TYR A 123
 None
 0.67A 5zmqH-2j6lA:
undetectable		 5zmqH-2j6lA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jg7 ANTIQUITIN

(Acanthopagrus
schlegelii) 		PF00171
(Aldedh) 		3 ALA A  91
VAL A 169
TYR A 121
 None
 0.66A 5zmqH-2jg7A:
undetectable		 5zmqH-2jg7A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kck TPR REPEAT

(Methanococcus
maripaludis) 		PF12895
(ANAPC3) 		3 ALA A  80
VAL A  66
TYR A  63
 None
 0.61A 5zmqH-2kckA:
undetectable		 5zmqH-2kckA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kn6 APOPTOSIS-ASSOCIATED
SPECK-LIKE PROTEIN
CONTAINING A CARD

(Homo sapiens) 		PF00619
(CARD)
PF02758
(PYRIN) 		3 ALA A 135
VAL A 149
TYR A 146
 None
 0.51A 5zmqH-2kn6A:
undetectable		 5zmqH-2kn6A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l29 INSULIN-LIKE GROWTH
FACTOR 2 RECEPTOR
VARIANT

(Homo sapiens) 		PF00878
(CIMR) 		3 ALA A1645
VAL A1584
TYR A1583
 None
 0.71A 5zmqH-2l29A:
undetectable		 5zmqH-2l29A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2g DIENELACTONE
HYDROLASE

(Trichormus
variabilis) 		PF01738
(DLH) 		3 ALA A  94
VAL A 141
TYR A 117
 None
 0.63A 5zmqH-2o2gA:
undetectable		 5zmqH-2o2gA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pa6 ENOLASE

(Methanocaldococcus
jannaschii) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		3 ALA A 178
VAL A 191
TYR A 239
 None
 0.69A 5zmqH-2pa6A:
undetectable		 5zmqH-2pa6A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pl2 HYPOTHETICAL
CONSERVED PROTEIN
TTC0263

(Thermus
thermophilus) 		PF13429
(TPR_15)
PF14559
(TPR_19) 		3 ALA A  91
VAL A 130
TYR A 100
 None
 0.63A 5zmqH-2pl2A:
undetectable		 5zmqH-2pl2A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rnr TRANSCRIPTION
INITIATION FACTOR
IIE SUBUNIT ALPHA

(Homo sapiens) 		PF11521
(TFIIE-A_C) 		3 ALA A 428
VAL A 408
TYR A 405
 None
 0.69A 5zmqH-2rnrA:
undetectable		 5zmqH-2rnrA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v2f PENICILLIN BINDING
PROTEIN 1A

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		3 ALA F 343
VAL F 279
TYR F 501
 None
 0.71A 5zmqH-2v2fF:
undetectable		 5zmqH-2v2fF:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v4y URIDYLATE KINASE

(Escherichia
coli) 		PF00696
(AA_kinase) 		3 ALA A 158
VAL A 230
TYR A   9
 None
 0.66A 5zmqH-2v4yA:
undetectable		 5zmqH-2v4yA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		3 ALA A  40
VAL A   9
TYR A  13
 ADP  A1303 (-3.5A)
None
None
 0.58A 5zmqH-2w4kA:
1.6		 5zmqH-2w4kA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wya HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		3 ALA A  58
VAL A 124
TYR A 189
 None
 0.69A 5zmqH-2wyaA:
undetectable		 5zmqH-2wyaA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xst LIPOCALIN 15

(Homo sapiens) 		PF00061
(Lipocalin) 		3 ALA A  20
VAL A 136
TYR A 123
 None
 0.70A 5zmqH-2xstA:
undetectable		 5zmqH-2xstA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yab DEATH-ASSOCIATED
PROTEIN KINASE 2

(Mus musculus) 		PF00069
(Pkinase) 		3 ALA A  40
VAL A   9
TYR A  13
 AMP  A1302 (-3.6A)
None
None
 0.62A 5zmqH-2yabA:
undetectable		 5zmqH-2yabA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yu4 E3 SUMO-PROTEIN
LIGASE NSE2

(Homo sapiens) 		PF11789
(zf-Nse) 		3 ALA A  49
VAL A  21
TYR A  30
 None
 0.68A 5zmqH-2yu4A:
undetectable		 5zmqH-2yu4A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A

(Homo sapiens) 		PF01593
(Amino_oxidase) 		3 ALA A 302
VAL A 189
TYR A 410
 None
 0.68A 5zmqH-2z5xA:
undetectable		 5zmqH-2z5xA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zo4 METALLO-BETA-LACTAMA
SE FAMILY PROTEIN

(Thermus
thermophilus) 		PF00753
(Lactamase_B) 		3 ALA A 229
VAL A  36
TYR A  25
 None
 0.68A 5zmqH-2zo4A:
undetectable		 5zmqH-2zo4A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ztg ALANYL-TRNA
SYNTHETASE

(Archaeoglobus
fulgidus) 		PF01411
(tRNA-synt_2c)
PF07973
(tRNA_SAD) 		3 ALA A 481
VAL A 456
TYR A 449
 None
 0.60A 5zmqH-2ztgA:
undetectable		 5zmqH-2ztgA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zyj ALPHA-AMINODIPATE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00155
(Aminotran_1_2) 		3 ALA A 131
VAL A 200
TYR A 167
 None
 0.64A 5zmqH-2zyjA:
undetectable		 5zmqH-2zyjA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aoe GLUTAMATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		3 ALA A 394
VAL A  26
TYR A  29
 None
 0.47A 5zmqH-3aoeA:
undetectable		 5zmqH-3aoeA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aov PUTATIVE
UNCHARACTERIZED
PROTEIN PH0207

(Pyrococcus
horikoshii) 		PF00155
(Aminotran_1_2) 		3 ALA A 160
VAL A 234
TYR A 201
 None
 0.59A 5zmqH-3aovA:
undetectable		 5zmqH-3aovA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1f PUTATIVE PREPHENATE
DEHYDROGENASE

(Streptococcus
mutans) 		PF02153
(PDH) 		3 ALA A  62
VAL A  32
TYR A   7
 None
 0.66A 5zmqH-3b1fA:
undetectable		 5zmqH-3b1fA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b97 ALPHA-ENOLASE

(Homo sapiens) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		3 ALA A 174
VAL A 187
TYR A 235
 None
 0.69A 5zmqH-3b97A:
undetectable		 5zmqH-3b97A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8z CYSTEINYL-TRNA
SYNTHETASE

(Mycolicibacterium
smegmatis) 		PF01406
(tRNA-synt_1e) 		3 ALA A 233
VAL A  79
TYR A  41
 None
 0.67A 5zmqH-3c8zA:
undetectable		 5zmqH-3c8zA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d5e PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE

(Homo sapiens) 		PF03403
(PAF-AH_p_II) 		3 ALA A 162
VAL A 174
TYR A  84
 None
 0.71A 5zmqH-3d5eA:
undetectable		 5zmqH-3d5eA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dea CUTINASE

(Colletotrichum
gloeosporioides) 		PF01083
(Cutinase) 		3 ALA A  74
VAL A 131
TYR A  51
 None
 0.51A 5zmqH-3deaA:
undetectable		 5zmqH-3deaA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7o MITOGEN-ACTIVATED
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		3 ALA A  53
VAL A  22
TYR A  26
 35F  A   1 (-3.6A)
None
None
 0.70A 5zmqH-3e7oA:
2.1		 5zmqH-3e7oA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3enk UDP-GLUCOSE
4-EPIMERASE

(Burkholderia
pseudomallei) 		PF16363
(GDP_Man_Dehyd) 		3 ALA A 129
VAL A  90
TYR A 152
 None
None
NAD  A 341 ( 4.5A)
 0.55A 5zmqH-3enkA:
undetectable		 5zmqH-3enkA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eq1 PORPHOBILINOGEN
DEAMINASE

(Homo sapiens) 		PF01379
(Porphobil_deam)
PF03900
(Porphobil_deamC) 		3 ALA A 219
VAL A 267
TYR A 213
 None
 0.65A 5zmqH-3eq1A:
undetectable		 5zmqH-3eq1A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3faj PUTATIVE
UNCHARACTERIZED
PROTEIN

(Acidianus
two-tailed
virus) 		no annotation 3 ALA A  65
VAL A  32
TYR A  29
 CL  A 133 ( 4.8A)
None
None
 0.69A 5zmqH-3fajA:
undetectable		 5zmqH-3fajA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g4e REGUCALCIN

(Homo sapiens) 		PF08450
(SGL) 		3 ALA A  79
VAL A 107
TYR A 113
 None
 0.70A 5zmqH-3g4eA:
undetectable		 5zmqH-3g4eA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gqi PHOSPHOLIPASE
C-GAMMA-1

(Rattus
norvegicus) 		PF00017
(SH2) 		3 ALA B 662
VAL B 693
TYR B 669
 None
 0.67A 5zmqH-3gqiB:
undetectable		 5zmqH-3gqiB:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4i GLYCOSYLTRANSFERASE
GTFA,
GLYCOSYLTRANSFERASE

(Actinoplanes
teichomyceticus;
Amycolatopsis
orientalis) 		PF03033
(Glyco_transf_28)
PF04101
(Glyco_tran_28_C) 		3 ALA A 107
VAL A  96
TYR A 119
 None
 0.69A 5zmqH-3h4iA:
undetectable		 5zmqH-3h4iA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7l ENDOGLUCANASE

(Vibrio
parahaemolyticus) 		PF00759
(Glyco_hydro_9)
PF02927
(CelD_N) 		3 ALA A  44
VAL A  90
TYR A  76
 None
 0.68A 5zmqH-3h7lA:
1.6		 5zmqH-3h7lA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hq9 CYTOCHROME C551
PEROXIDASE

(Geobacter
sulfurreducens) 		PF00034
(Cytochrom_C)
PF03150
(CCP_MauG) 		3 ALA A 315
VAL A 287
TYR A 281
 None
 0.54A 5zmqH-3hq9A:
undetectable		 5zmqH-3hq9A:
22.03