SIMILAR PATTERNS OF AMINO ACIDS FOR 5ZMQ_I_PACI1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5l UREASE (BETA
SUBUNIT)
UREASE (ALPHA
SUBUNIT)

(Klebsiella
aerogenes;
Klebsiella
aerogenes) 		PF00699
(Urease_beta)
PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		3 VAL B  82
TYR B  59
GLU C  41
 None
 0.85A 5zmqD-1a5lB:
0.0
5zmqE-1a5lB:
undetectable		 5zmqD-1a5lB:
19.66
5zmqE-1a5lB:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dce PROTEIN (RAB
GERANYLGERANYLTRANSF
ERASE ALPHA SUBUNIT)

(Rattus
norvegicus) 		PF01239
(PPTA)
PF07711
(RabGGT_insert) 		3 VAL A 215
TYR A 231
GLU A 367
 None
 0.77A 5zmqD-1dceA:
0.0
5zmqE-1dceA:
undetectable		 5zmqD-1dceA:
14.03
5zmqE-1dceA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3h GUANOSINE
PENTAPHOSPHATE
SYNTHETASE

(Streptomyces
antibioticus) 		PF00013
(KH_1)
PF01138
(RNase_PH)
PF03726
(PNPase) 		3 VAL A 436
TYR A 400
GLU A 204
 None
None
SO4  A 906 (-3.4A)
 0.92A 5zmqD-1e3hA:
0.0
5zmqE-1e3hA:
undetectable		 5zmqD-1e3hA:
14.34
5zmqE-1e3hA:
5.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gy8 UDP-GALACTOSE
4-EPIMERASE

(Trypanosoma
brucei) 		PF01370
(Epimerase) 		3 VAL A 267
TYR A 341
GLU A 314
 None
 0.98A 5zmqD-1gy8A:
undetectable
5zmqE-1gy8A:
undetectable		 5zmqD-1gy8A:
20.92
5zmqE-1gy8A:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ieh BRUC.D4.4

(Lama glama) 		PF07686
(V-set) 		3 VAL A  64
TYR A  60
GLU A  46
 None
 0.96A 5zmqD-1iehA:
0.0
5zmqE-1iehA:
undetectable		 5zmqD-1iehA:
22.29
5zmqE-1iehA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE

(Pyrococcus
horikoshii) 		PF00291
(PALP) 		3 VAL A 291
TYR A 288
GLU A  33
 None
 0.81A 5zmqD-1j0aA:
0.0
5zmqE-1j0aA:
undetectable		 5zmqD-1j0aA:
23.18
5zmqE-1j0aA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jjf ENDO-1,4-BETA-XYLANA
SE Z

(Ruminiclostridium
thermocellum) 		PF00756
(Esterase) 		3 VAL A  51
TYR A  70
GLU A  99
 None
 0.75A 5zmqD-1jjfA:
0.0
5zmqE-1jjfA:
undetectable		 5zmqD-1jjfA:
24.73
5zmqE-1jjfA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jvb NAD(H)-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Sulfolobus
solfataricus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 VAL A   4
TYR A 126
GLU A 325
 None
 0.97A 5zmqD-1jvbA:
0.0
5zmqE-1jvbA:
undetectable		 5zmqD-1jvbA:
22.19
5zmqE-1jvbA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jx2 MYOSIN-2 HEAVY
CHAIN,DYNAMIN-A

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		3 VAL A 324
TYR A 293
GLU A 313
 None
 0.99A 5zmqD-1jx2A:
undetectable
5zmqE-1jx2A:
undetectable		 5zmqD-1jx2A:
10.65
5zmqE-1jx2A:
4.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k2p TYROSINE-PROTEIN
KINASE BTK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 VAL A 448
TYR A 545
GLU A 444
 None
 0.94A 5zmqD-1k2pA:
undetectable
5zmqE-1k2pA:
undetectable		 5zmqD-1k2pA:
20.40
5zmqE-1k2pA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kop CARBONIC ANHYDRASE

(Neisseria
gonorrhoeae) 		PF00194
(Carb_anhydrase) 		3 VAL A 189
TYR A 170
GLU A 109
 None
 0.91A 5zmqD-1kopA:
undetectable
5zmqE-1kopA:
undetectable		 5zmqD-1kopA:
22.32
5zmqE-1kopA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lwh 4-ALPHA-GLUCANOTRANS
FERASE

(Thermotoga
maritima) 		PF00128
(Alpha-amylase)
PF09178
(DUF1945) 		3 VAL A 405
TYR A 406
GLU A 429
 None
 0.86A 5zmqD-1lwhA:
undetectable
5zmqE-1lwhA:
undetectable		 5zmqD-1lwhA:
18.20
5zmqE-1lwhA:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mf1 ADENYLOSUCCINATE
SYNTHETASE

(Mus musculus) 		PF00709
(Adenylsucc_synt) 		3 VAL A  73
TYR A  80
GLU A 253
 None
 0.74A 5zmqD-1mf1A:
undetectable
5zmqE-1mf1A:
undetectable		 5zmqD-1mf1A:
20.45
5zmqE-1mf1A:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oi7 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN

(Thermus
thermophilus) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		3 VAL A  38
TYR A  53
GLU A  83
 None
 0.91A 5zmqD-1oi7A:
undetectable
5zmqE-1oi7A:
undetectable		 5zmqD-1oi7A:
20.91
5zmqE-1oi7A:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p75 THYMIDINE KINASE

(Equid
alphaherpesvirus
4) 		PF00693
(Herpes_TK) 		3 VAL A 136
TYR A  57
GLU A 320
 None
 0.87A 5zmqD-1p75A:
undetectable
5zmqE-1p75A:
undetectable		 5zmqD-1p75A:
18.26
5zmqE-1p75A:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pjq SIROHEME SYNTHASE

(Salmonella
enterica) 		PF00590
(TP_methylase)
PF10414
(CysG_dimeriser)
PF13241
(NAD_binding_7)
PF14824
(Sirohm_synth_M) 		3 VAL A 246
TYR A 247
GLU A 313
 None
 1.00A 5zmqD-1pjqA:
undetectable
5zmqE-1pjqA:
undetectable		 5zmqD-1pjqA:
18.45
5zmqE-1pjqA:
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1si1 IRON BINDING PROTEIN
FBPA

(Mannheimia
haemolytica) 		PF13343
(SBP_bac_6) 		3 VAL A  58
TYR A   9
GLU A 268
 None
 0.87A 5zmqD-1si1A:
undetectable
5zmqE-1si1A:
undetectable		 5zmqD-1si1A:
21.77
5zmqE-1si1A:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sra SPARC

(Homo sapiens) 		PF10591
(SPARC_Ca_bdg) 		3 VAL A 159
TYR A 162
GLU A 190
 None
 0.99A 5zmqD-1sraA:
undetectable
5zmqE-1sraA:
undetectable		 5zmqD-1sraA:
21.58
5zmqE-1sraA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ut9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9)
PF02927
(CelD_N) 		3 VAL A 392
TYR A 555
GLU A 563
 None
 0.77A 5zmqD-1ut9A:
undetectable
5zmqE-1ut9A:
undetectable		 5zmqD-1ut9A:
15.69
5zmqE-1ut9A:
6.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v7v CHITOBIOSE
PHOSPHORYLASE

(Vibrio
proteolyticus) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		3 VAL A 631
TYR A 632
GLU A 637
 None
 0.99A 5zmqD-1v7vA:
undetectable
5zmqE-1v7vA:
undetectable		 5zmqD-1v7vA:
12.20
5zmqE-1v7vA:
5.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vk8 HYPOTHETICAL PROTEIN
TM0486

(Thermotoga
maritima) 		PF01910
(Thiamine_BP) 		3 VAL A  90
TYR A  93
GLU A  38
 None
 0.93A 5zmqD-1vk8A:
undetectable
5zmqE-1vk8A:
undetectable		 5zmqD-1vk8A:
18.13
5zmqE-1vk8A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w93 ACETYL-COENZYME A
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		3 VAL A  72
TYR A 109
GLU A 477
 None
 0.62A 5zmqD-1w93A:
undetectable
5zmqE-1w93A:
undetectable		 5zmqD-1w93A:
15.30
5zmqE-1w93A:
7.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wop AMINOMETHYLTRANSFERA
SE

(Thermotoga
maritima) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		3 VAL A  98
TYR A  83
GLU A 195
 FFO  A2887 (-4.0A)
FFO  A2887 (-3.9A)
FFO  A2887 (-2.8A)
 0.97A 5zmqD-1wopA:
undetectable
5zmqE-1wopA:
undetectable		 5zmqD-1wopA:
19.01
5zmqE-1wopA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yt8 THIOSULFATE
SULFURTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00581
(Rhodanese) 		3 VAL A 112
TYR A 490
GLU A 313
 None
 0.83A 5zmqD-1yt8A:
undetectable
5zmqE-1yt8A:
undetectable		 5zmqD-1yt8A:
17.05
5zmqE-1yt8A:
8.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbt PEPTIDE CHAIN
RELEASE FACTOR 1

(Streptococcus
mutans) 		PF00472
(RF-1)
PF03462
(PCRF) 		3 VAL A 186
TYR A 311
GLU A 125
 None
 0.86A 5zmqD-1zbtA:
undetectable
5zmqE-1zbtA:
undetectable		 5zmqD-1zbtA:
18.82
5zmqE-1zbtA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ani RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA SUBUNIT

(Chlamydia
trachomatis) 		PF00268
(Ribonuc_red_sm) 		3 VAL A  92
TYR A 188
GLU A 227
 None
None
FE  A 347 ( 2.1A)
 0.73A 5zmqD-2aniA:
undetectable
5zmqE-2aniA:
undetectable		 5zmqD-2aniA:
20.18
5zmqE-2aniA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1

(Homo sapiens) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		3 VAL A 612
TYR A 480
GLU A 183
 None
 0.97A 5zmqD-2b3xA:
undetectable
5zmqE-2b3xA:
undetectable		 5zmqD-2b3xA:
12.88
5zmqE-2b3xA:
4.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cl2 PUTATIVE
LAMINARINASE

(Phanerochaete
chrysosporium) 		no annotation 3 VAL A 296
TYR A 297
GLU A 104
 None
 0.93A 5zmqD-2cl2A:
undetectable
5zmqE-2cl2A:
undetectable		 5zmqD-2cl2A:
20.86
5zmqE-2cl2A:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dht 409AA LONG
HYPOTHETICAL
NADP-DEPENDENT
ISOCITRATE
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00180
(Iso_dh) 		3 VAL A 295
TYR A 299
GLU A 231
 None
 0.79A 5zmqD-2dhtA:
undetectable
5zmqE-2dhtA:
undetectable		 5zmqD-2dhtA:
19.15
5zmqE-2dhtA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2du7 O-PHOSPHOSERYL-TRNA
SYNTHETASE

(Methanocaldococcus
jannaschii) 		PF01409
(tRNA-synt_2d) 		3 VAL A 436
TYR A 479
GLU A 424
 None
 0.94A 5zmqD-2du7A:
undetectable
5zmqE-2du7A:
undetectable		 5zmqD-2du7A:
16.45
5zmqE-2du7A:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fkn UROCANATE HYDRATASE

(Bacillus
subtilis) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		3 VAL A 490
TYR A 494
GLU A 452
 None
 0.81A 5zmqD-2fknA:
undetectable
5zmqE-2fknA:
undetectable		 5zmqD-2fknA:
17.96
5zmqE-2fknA:
7.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqd BLUE COPPER OXIDASE
CUEO

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 VAL A 516
TYR A 496
GLU A 430
 None
 0.95A 5zmqD-2fqdA:
undetectable
5zmqE-2fqdA:
undetectable		 5zmqD-2fqdA:
18.59
5zmqE-2fqdA:
6.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hyx PROTEIN DIPZ

(Mycobacterium
tuberculosis) 		PF00578
(AhpC-TSA) 		3 VAL A 461
TYR A 451
GLU A 511
 None
 0.98A 5zmqD-2hyxA:
undetectable
5zmqE-2hyxA:
undetectable		 5zmqD-2hyxA:
21.65
5zmqE-2hyxA:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9k MODIFICATION
METHYLASE HHAI

(Haemophilus
haemolyticus) 		PF00145
(DNA_methylase) 		3 VAL A 227
TYR A 242
GLU A 218
 None
 0.97A 5zmqD-2i9kA:
undetectable
5zmqE-2i9kA:
undetectable		 5zmqD-2i9kA:
20.65
5zmqE-2i9kA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuk SEED LIPOXYGENASE

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		3 VAL A  88
TYR A  89
GLU A 112
 None
 0.84A 5zmqD-2iukA:
undetectable
5zmqE-2iukA:
undetectable		 5zmqD-2iukA:
11.88
5zmqE-2iukA:
5.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuy GLYCOSYLTRANSFERASE

(Streptomyces
viridochromogenes) 		PF00534
(Glycos_transf_1) 		3 VAL A 152
TYR A 135
GLU A 288
 None
 0.95A 5zmqD-2iuyA:
undetectable
5zmqE-2iuyA:
undetectable		 5zmqD-2iuyA:
21.25
5zmqE-2iuyA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3h NADP-DEPENDENT
OXIDOREDUCTASE P1

(Arabidopsis
thaliana) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		3 VAL A  30
TYR A 109
GLU A  36
 None
 0.97A 5zmqD-2j3hA:
undetectable
5zmqE-2j3hA:
undetectable		 5zmqD-2j3hA:
20.40
5zmqE-2j3hA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ji9 OXALYL-COA
DECARBOXYLASE

(Oxalobacter
formigenes) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 VAL A 436
TYR A  51
GLU A 461
 None
 0.98A 5zmqD-2ji9A:
undetectable
5zmqE-2ji9A:
undetectable		 5zmqD-2ji9A:
16.19
5zmqE-2ji9A:
8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pnz PROBABLE EXOSOME
COMPLEX EXONUCLEASE
1

(Pyrococcus
abyssi) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		3 VAL A 172
TYR A  24
GLU A 179
 None
 0.86A 5zmqD-2pnzA:
undetectable
5zmqE-2pnzA:
undetectable		 5zmqD-2pnzA:
22.27
5zmqE-2pnzA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wxz ANGIOTENSINOGEN

(Rattus
norvegicus) 		PF00079
(Serpin) 		3 VAL A 174
TYR A 248
GLU A  48
 None
 0.88A 5zmqD-2wxzA:
undetectable
5zmqE-2wxzA:
undetectable		 5zmqD-2wxzA:
17.66
5zmqE-2wxzA:
8.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yh0 SPLICING FACTOR U2AF
65 KDA SUBUNIT

(Homo sapiens) 		PF00076
(RRM_1) 		3 VAL A 312
TYR A 307
GLU A 201
 None
 0.90A 5zmqD-2yh0A:
undetectable
5zmqE-2yh0A:
undetectable		 5zmqD-2yh0A:
22.44
5zmqE-2yh0A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6b GLUTARYL-COA
DEHYDROGENASE

(Burkholderia
pseudomallei) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		3 VAL A 370
TYR A 373
GLU A  90
 None
 0.84A 5zmqD-3d6bA:
undetectable
5zmqE-3d6bA:
undetectable		 5zmqD-3d6bA:
20.65
5zmqE-3d6bA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epj TRNA
ISOPENTENYLTRANSFERA
SE

(Saccharomyces
cerevisiae) 		PF01715
(IPPT) 		3 VAL A  77
TYR A  51
GLU A  91
 None
 0.95A 5zmqD-3epjA:
undetectable
5zmqE-3epjA:
undetectable		 5zmqD-3epjA:
19.05
5zmqE-3epjA:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fe4 CARBONIC ANHYDRASE 6

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		3 VAL A 232
TYR A 213
GLU A 136
 None
 0.95A 5zmqD-3fe4A:
undetectable
5zmqE-3fe4A:
undetectable		 5zmqD-3fe4A:
21.22
5zmqE-3fe4A:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gpr RHODOCETIN SUBUNIT
BETA

(Calloselasma
rhodostoma) 		PF00059
(Lectin_C) 		3 VAL B2100
TYR B2111
GLU B2117
 None
 0.95A 5zmqD-3gprB:
undetectable
5zmqE-3gprB:
undetectable		 5zmqD-3gprB:
18.13
5zmqE-3gprB:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gu0 TRIGGER FACTOR

(Thermotoga
maritima) 		PF05697
(Trigger_N)
PF05698
(Trigger_C) 		3 VAL A 193
TYR A 182
GLU A 188
 None
 0.81A 5zmqD-3gu0A:
undetectable
5zmqE-3gu0A:
undetectable		 5zmqD-3gu0A:
19.16
5zmqE-3gu0A:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzs UNCHARACTERIZED SUSD
SUPERFAMILY PROTEIN

(Bacteroides
fragilis) 		PF12741
(SusD-like) 		3 VAL A 124
TYR A 128
GLU A 509
 None
 0.84A 5zmqD-3gzsA:
undetectable
5zmqE-3gzsA:
undetectable		 5zmqD-3gzsA:
18.47
5zmqE-3gzsA:
7.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 9

(Thermus
thermophilus) 		PF12838
(Fer4_7) 		3 VAL 9 166
TYR 9 165
GLU 9 171
 None
 0.96A 5zmqD-3i9v9:
undetectable
5zmqE-3i9v9:
undetectable		 5zmqD-3i9v9:
22.64
5zmqE-3i9v9:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jxf RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE ZETA

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		3 VAL A 248
TYR A 229
GLU A 152
 None
 0.93A 5zmqD-3jxfA:
undetectable
5zmqE-3jxfA:
undetectable		 5zmqD-3jxfA:
24.44
5zmqE-3jxfA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k70 EXODEOXYRIBONUCLEASE
V ALPHA CHAIN

(Escherichia
coli) 		PF13538
(UvrD_C_2)
PF13604
(AAA_30) 		3 VAL D 570
TYR D 567
GLU D 394
 None
 0.92A 5zmqD-3k70D:
undetectable
5zmqE-3k70D:
undetectable		 5zmqD-3k70D:
14.97
5zmqE-3k70D:
5.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxu TRIPEPTIDYL-PEPTIDAS
E 2

(Drosophila
melanogaster) 		PF00082
(Peptidase_S8)
PF12580
(TPPII)
PF12583
(TPPII_N) 		3 VAL X1307
TYR X1304
GLU X1322
 None
 0.92A 5zmqD-3lxuX:
undetectable
5zmqE-3lxuX:
undetectable		 5zmqD-3lxuX:
8.34
5zmqE-3lxuX:
3.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nom GLUTAMINE
CYCLOTRANSFERASE

(Zymomonas
mobilis) 		PF05096
(Glu_cyclase_2) 		3 VAL A 249
TYR A  37
GLU A  57
 None
 0.76A 5zmqD-3nomA:
undetectable
5zmqE-3nomA:
undetectable		 5zmqD-3nomA:
22.47
5zmqE-3nomA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8c NCK-ASSOCIATED
PROTEIN 1

(Homo sapiens) 		PF09735
(Nckap1) 		3 VAL B1119
TYR B1120
GLU B1082
 None
 0.99A 5zmqD-3p8cB:
undetectable
5zmqE-3p8cB:
undetectable		 5zmqD-3p8cB:
9.66
5zmqE-3p8cB:
3.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ps5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 6

(Homo sapiens) 		PF00017
(SH2)
PF00102
(Y_phosphatase) 		3 VAL A 332
TYR A 364
GLU A 329
 None
 0.89A 5zmqD-3ps5A:
undetectable
5zmqE-3ps5A:
undetectable		 5zmqD-3ps5A:
14.96
5zmqE-3ps5A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6

(Saccharomyces
cerevisiae) 		PF14635
(HHH_7)
PF14639
(YqgF)
PF14641
(HTH_44)
PF14878
(DLD) 		3 VAL A 925
TYR A 950
GLU A 387
 None
 0.72A 5zmqD-3psfA:
undetectable
5zmqE-3psfA:
undetectable		 5zmqD-3psfA:
9.32
5zmqE-3psfA:
5.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psi TRANSCRIPTION
ELONGATION FACTOR
SPT6

(Saccharomyces
cerevisiae) 		PF14635
(HHH_7)
PF14639
(YqgF)
PF14641
(HTH_44)
PF14878
(DLD) 		3 VAL A 925
TYR A 950
GLU A 387
 None
 0.71A 5zmqD-3psiA:
undetectable
5zmqE-3psiA:
undetectable		 5zmqD-3psiA:
8.31
5zmqE-3psiA:
5.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pzl AGMATINE
UREOHYDROLASE

(Thermoplasma
volcanium) 		PF00491
(Arginase) 		3 VAL A  96
TYR A 158
GLU A 123
 None
 0.93A 5zmqD-3pzlA:
undetectable
5zmqE-3pzlA:
undetectable		 5zmqD-3pzlA:
21.91
5zmqE-3pzlA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rim TRANSKETOLASE

(Mycobacterium
tuberculosis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		3 VAL A  27
TYR A  57
GLU A 241
 None
 0.64A 5zmqD-3rimA:
undetectable
5zmqE-3rimA:
undetectable		 5zmqD-3rimA:
13.69
5zmqE-3rimA:
6.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rx8 CELLULASE

(Alicyclobacillus
acidocaldarius) 		PF00759
(Glyco_hydro_9)
PF02927
(CelD_N) 		3 VAL A 152
TYR A 300
GLU A 308
 None
9MR  A 601 (-4.2A)
CA  A 538 (-2.1A)
 0.87A 5zmqD-3rx8A:
undetectable
5zmqE-3rx8A:
undetectable		 5zmqD-3rx8A:
18.06
5zmqE-3rx8A:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tef IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-COMPOUND-BINDIN
G PROTEIN

(Vibrio cholerae) 		PF01497
(Peripla_BP_2) 		3 VAL A 153
TYR A 142
GLU A 157
 None
 0.94A 5zmqD-3tefA:
undetectable
5zmqE-3tefA:
undetectable		 5zmqD-3tefA:
20.66
5zmqE-3tefA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9s METHYLCROTONYL-COA
CARBOXYLASE,
ALPHA-SUBUNIT

(Pseudomonas
aeruginosa) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		3 VAL A 217
TYR A 249
GLU A 223
 None
 1.00A 5zmqD-3u9sA:
undetectable
5zmqE-3u9sA:
undetectable		 5zmqD-3u9sA:
12.29
5zmqE-3u9sA:
6.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vm7 ALPHA-AMYLASE

(Malbranchea
cinnamomea) 		PF00128
(Alpha-amylase)
PF09260
(DUF1966) 		3 VAL A 202
TYR A 165
GLU A 198
 None
 0.89A 5zmqD-3vm7A:
1.5
5zmqE-3vm7A:
undetectable		 5zmqD-3vm7A:
16.50
5zmqE-3vm7A:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vr5 V-TYPE SODIUM ATPASE
CATALYTIC SUBUNIT A
V-TYPE SODIUM ATPASE
SUBUNIT B

(Enterococcus
hirae;
Enterococcus
hirae) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
PF16886
(ATP-synt_ab_Xtn)
PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		3 VAL A   9
TYR D  26
GLU A  62
 None
 0.91A 5zmqD-3vr5A:
undetectable
5zmqE-3vr5A:
undetectable		 5zmqD-3vr5A:
15.51
5zmqE-3vr5A:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdj TYPE I PULLULANASE

(Anoxybacillus
sp. LM18-11) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		3 VAL A 390
TYR A 364
GLU A 386
 None
 0.87A 5zmqD-3wdjA:
2.0
5zmqE-3wdjA:
undetectable		 5zmqD-3wdjA:
13.90
5zmqE-3wdjA:
6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1d ATLASTIN

(Drosophila
melanogaster) 		PF02263
(GBP) 		3 VAL A 286
TYR A 287
GLU A 238
 None
 0.98A 5zmqD-3x1dA:
undetectable
5zmqE-3x1dA:
undetectable		 5zmqD-3x1dA:
15.96
5zmqE-3x1dA:
7.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aio LIMIT DEXTRINASE

(Hordeum vulgare) 		PF02922
(CBM_48)
PF11852
(DUF3372) 		3 VAL A 450
TYR A 425
GLU A 446
 None
 0.95A 5zmqD-4aioA:
undetectable
5zmqE-4aioA:
undetectable		 5zmqD-4aioA:
11.92
5zmqE-4aioA:
5.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c90 ALPHA-GLUCURONIDASE
GH115

(Bacteroides
ovatus) 		PF15979
(Glyco_hydro_115) 		3 VAL A 833
TYR A 683
GLU A 801
 None
 0.96A 5zmqD-4c90A:
undetectable
5zmqE-4c90A:
undetectable		 5zmqD-4c90A:
12.61
5zmqE-4c90A:
5.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gtv GERANYLGERANYL
TRANSFERASE TYPE-2
SUBUNIT ALPHA

(Rattus
norvegicus) 		PF01239
(PPTA) 		3 VAL A 215
TYR A 231
GLU A 256
 None
 0.66A 5zmqD-4gtvA:
undetectable
5zmqE-4gtvA:
undetectable		 5zmqD-4gtvA:
20.66
5zmqE-4gtvA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN

(Lactobacillus
acidophilus) 		PF06100
(MCRA) 		3 VAL A 506
TYR A 471
GLU A 499
 None
 0.91A 5zmqD-4ia5A:
undetectable
5zmqE-4ia5A:
undetectable		 5zmqD-4ia5A:
16.25
5zmqE-4ia5A:
7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4il3 STE24P

(Saccharomyces
mikatae) 		PF01435
(Peptidase_M48)
PF16491
(Peptidase_M48_N) 		3 VAL A 423
TYR A 427
GLU A 439
 None
 0.84A 5zmqD-4il3A:
undetectable
5zmqE-4il3A:
undetectable		 5zmqD-4il3A:
17.57
5zmqE-4il3A:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lz6 BH2163 PROTEIN

(Bacillus
halodurans) 		PF01554
(MatE) 		3 VAL A 195
TYR A 139
GLU A  51
 None
 0.88A 5zmqD-4lz6A:
undetectable
5zmqE-4lz6A:
undetectable		 5zmqD-4lz6A:
16.48
5zmqE-4lz6A:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ne4 ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN
(PROLINE/GLYCINE/BET
AINE)

(Agrobacterium
fabrum) 		PF04069
(OpuAC) 		3 VAL A 100
TYR A  94
GLU A 242
 None
 0.83A 5zmqD-4ne4A:
undetectable
5zmqE-4ne4A:
undetectable		 5zmqD-4ne4A:
22.65
5zmqE-4ne4A:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ojh ACYLPHOSPHATASE

(Sulfolobus
solfataricus) 		PF00708
(Acylphosphatase) 		3 VAL A  57
TYR A  17
GLU A  94
 None
SO4  A 203 (-4.6A)
None
 0.63A 5zmqD-4ojhA:
undetectable
5zmqE-4ojhA:
undetectable		 5zmqD-4ojhA:
19.89
5zmqE-4ojhA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pmh PECTINESTERASE

(Sitophilus
oryzae) 		PF01095
(Pectinesterase) 		3 VAL A  44
TYR A  48
GLU A  78
 None
 0.82A 5zmqD-4pmhA:
undetectable
5zmqE-4pmhA:
undetectable		 5zmqD-4pmhA:
17.40
5zmqE-4pmhA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tma DNA GYRASE SUBUNIT B

(Escherichia
coli) 		PF00986
(DNA_gyraseB_C)
PF01751
(Toprim) 		3 VAL B 666
TYR B 675
GLU B 641
 None
 0.94A 5zmqD-4tmaB:
undetectable
5zmqE-4tmaB:
undetectable		 5zmqD-4tmaB:
17.73
5zmqE-4tmaB:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4twl DIOSCORIN 5

(Dioscorea
japonica) 		PF00194
(Carb_anhydrase) 		3 VAL A 195
TYR A 176
GLU A 112
 None
 0.90A 5zmqD-4twlA:
undetectable
5zmqE-4twlA:
undetectable		 5zmqD-4twlA:
19.76
5zmqE-4twlA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4urm DNA GYRASE SUBUNIT B

(Staphylococcus
aureus) 		PF02518
(HATPase_c) 		3 VAL A 174
TYR A 141
GLU A  68
 None
 0.99A 5zmqD-4urmA:
undetectable
5zmqE-4urmA:
undetectable		 5zmqD-4urmA:
22.69
5zmqE-4urmA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xfk PUTATIVE BRANCHED
CHAIN AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Brucella ovis) 		PF13458
(Peripla_BP_6) 		3 VAL A 359
TYR A 356
GLU A 116
 None
 0.79A 5zmqD-4xfkA:
undetectable
5zmqE-4xfkA:
undetectable		 5zmqD-4xfkA:
19.19
5zmqE-4xfkA:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xz5 CARBONIC ANHYDRASE,
ALPHA FAMILY

(Hydrogenovibrio
crunogenus) 		PF00194
(Carb_anhydrase) 		3 VAL A 264
TYR A 245
GLU A 182
 None
 0.90A 5zmqD-4xz5A:
undetectable
5zmqE-4xz5A:
undetectable		 5zmqD-4xz5A:
23.79
5zmqE-4xz5A:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yfl 1B2530 HEAVY CHAIN
1B2530 LIGHT CHAIN

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		3 VAL H 181
TYR H 188
GLU L 160
 None
 0.93A 5zmqD-4yflH:
undetectable
5zmqE-4yflH:
undetectable		 5zmqD-4yflH:
21.55
5zmqE-4yflH:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b6k UNCHARACTERIZED
PROTEIN CGKR1

([Candida]
glabrata) 		PF01370
(Epimerase) 		3 VAL A 216
TYR A 215
GLU A 346
 None
 0.93A 5zmqD-5b6kA:
undetectable
5zmqE-5b6kA:
undetectable		 5zmqD-5b6kA:
19.62
5zmqE-5b6kA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bqs 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Streptococcus
pneumoniae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		3 VAL A  13
TYR A  12
GLU A 276
 None
 0.88A 5zmqD-5bqsA:
undetectable
5zmqE-5bqsA:
undetectable		 5zmqD-5bqsA:
20.54
5zmqE-5bqsA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bv9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Bacillus
pumilus) 		PF02011
(Glyco_hydro_48) 		3 VAL A 326
TYR A 237
GLU A 420
 None
 0.73A 5zmqD-5bv9A:
undetectable
5zmqE-5bv9A:
undetectable		 5zmqD-5bv9A:
13.36
5zmqE-5bv9A:
6.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e04 NUCLEOPROTEIN

(Andes
orthohantavirus) 		PF00846
(Hanta_nucleocap) 		3 VAL A 272
TYR A 320
GLU A 326
 None
 0.96A 5zmqD-5e04A:
undetectable
5zmqE-5e04A:
undetectable		 5zmqD-5e04A:
18.75
5zmqE-5e04A:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e5u RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE GAMMA

(Mus musculus) 		PF00194
(Carb_anhydrase) 		3 VAL A 269
TYR A 250
GLU A 173
 None
 0.95A 5zmqD-5e5uA:
undetectable
5zmqE-5e5uA:
undetectable		 5zmqD-5e5uA:
19.56
5zmqE-5e5uA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fkr ENDO-1,4-BETA-GLUCAN
ASE/XYLOGLUCANASE,
PUTATIVE, GLY74A

(Cellvibrio
japonicus) 		no annotation 3 VAL A 279
TYR A 288
GLU A 419
 None
 0.94A 5zmqD-5fkrA:
undetectable
5zmqE-5fkrA:
undetectable		 5zmqD-5fkrA:
14.41
5zmqE-5fkrA:
6.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmf DNA REPAIR HELICASE
RAD25, SSL2

(Saccharomyces
cerevisiae) 		PF04851
(ResIII)
PF16203
(ERCC3_RAD25_C) 		3 VAL 1 313
TYR 1 335
GLU 1 305
 None
 0.81A 5zmqD-5fmf1:
undetectable
5zmqE-5fmf1:
undetectable		 5zmqD-5fmf1:
17.26
5zmqE-5fmf1:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzu CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		3 VAL A 782
TYR A 893
GLU A 882
 None
 0.97A 5zmqD-5gzuA:
undetectable
5zmqE-5gzuA:
undetectable		 5zmqD-5gzuA:
12.04
5zmqE-5gzuA:
4.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hca CALRETICULIN,CALRETI
CULIN

(Entamoeba
histolytica) 		no annotation 3 VAL C  16
TYR C  17
GLU C 337
 None
 0.99A 5zmqD-5hcaC:
undetectable
5zmqE-5hcaC:
undetectable		 5zmqD-5hcaC:
20.88
5zmqE-5hcaC:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hpj CARBONIC ANHYDRASE

(Photobacterium
profundum) 		PF00194
(Carb_anhydrase) 		3 VAL A 194
TYR A 175
GLU A 113
 None
 0.93A 5zmqD-5hpjA:
undetectable
5zmqE-5hpjA:
undetectable		 5zmqD-5hpjA:
21.62
5zmqE-5hpjA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i92 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Pseudomonas
aeruginosa) 		PF00202
(Aminotran_3) 		3 VAL A 245
TYR A 253
GLU A 238
 None
 0.95A 5zmqD-5i92A:
undetectable
5zmqE-5i92A:
undetectable		 5zmqD-5i92A:
18.14
5zmqE-5i92A:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5klh SURFACE GLYCOPROTEIN

(Trypanosoma
brucei) 		no annotation 3 VAL A  90
TYR A  91
GLU A  61
 None
 0.98A 5zmqD-5klhA:
undetectable
5zmqE-5klhA:
undetectable		 5zmqD-5klhA:
23.05
5zmqE-5klhA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kp7 CURD

(Moorea
producens) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		3 VAL A 394
TYR A 360
GLU A  49
 None
 0.94A 5zmqD-5kp7A:
undetectable
5zmqE-5kp7A:
undetectable		 5zmqD-5kp7A:
17.15
5zmqE-5kp7A:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		3 VAL A 514
TYR A 497
GLU A 519
 None
 0.99A 5zmqD-5okoA:
undetectable
5zmqE-5okoA:
undetectable		 5zmqD-5okoA:
18.48
5zmqE-5okoA:
7.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t9j FLAP ENDONUCLEASE
GEN HOMOLOG 1

(Homo sapiens) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		3 VAL A 166
TYR A 167
GLU A 136
 None
 0.90A 5zmqD-5t9jA:
undetectable
5zmqE-5t9jA:
undetectable		 5zmqD-5t9jA:
16.88
5zmqE-5t9jA:
6.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uve SUBSTRATE-BINDING
REGION OF ABC-TYPE
GLYCINE BETAINE
TRANSPORT SYSTEM

(Brucella
abortus) 		PF04069
(OpuAC) 		3 VAL A 118
TYR A 112
GLU A 260
 None
 0.71A 5zmqD-5uveA:
undetectable
5zmqE-5uveA:
undetectable		 5zmqD-5uveA:
21.80
5zmqE-5uveA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w16 GLUTAMATE RACEMASE

(Thermus
thermophilus) 		no annotation 3 VAL A  42
TYR A  44
GLU A 145
 NO3  A 302 (-4.9A)
DGL  A 301 (-4.9A)
NO3  A 302 ( 4.0A)
 0.87A 5zmqD-5w16A:
undetectable
5zmqE-5w16A:
undetectable		 5zmqD-5w16A:
undetectable
5zmqE-5w16A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cay STEROL-BINDING
PROTEIN

(Saccharomyces
cerevisiae) 		no annotation 3 VAL A 960
TYR A 976
GLU A 930
 None
 0.85A 5zmqD-6cayA:
undetectable
5zmqE-6cayA:
undetectable		 5zmqD-6cayA:
undetectable
5zmqE-6cayA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6q EXOSOME COMPLEX
COMPONENT RRP40

(Homo sapiens) 		no annotation 3 VAL G 230
TYR G 164
GLU G 228
 None
 0.95A 5zmqD-6d6qG:
undetectable
5zmqE-6d6qG:
undetectable		 5zmqD-6d6qG:
undetectable
5zmqE-6d6qG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eki CARBONIC ANHYDRASE

(Persephonella
marina) 		no annotation 3 VAL A 214
TYR A 195
GLU A 134
 None
 0.91A 5zmqD-6ekiA:
undetectable
5zmqE-6ekiA:
undetectable		 5zmqD-6ekiA:
undetectable
5zmqE-6ekiA:
undetectable