SIMILAR PATTERNS OF AMINO ACIDS FOR 5ZHM_B_SAMB301_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkw FE(III)-PYOCHELIN
RECEPTOR

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 ARG A 333
SER A 267
ASP A 266
HIS A 264
 None
 1.49A 5zhmA-1xkwA:
undetectable		 5zhmA-1xkwA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yir NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE 2

(Pseudomonas
aeruginosa) 		PF04095
(NAPRTase) 		4 ARG A 182
SER A 319
ASP A 289
HIS A 226
 SO4  A2002 ( 4.8A)
None
SO4  A2001 ( 4.2A)
SO4  A2001 (-3.7A)
 1.29A 5zhmA-1yirA:
0.0		 5zhmA-1yirA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z8l GLUTAMATE
CARBOXYPEPTIDASE II

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		4 ARG A 534
SER A 454
ASP A 387
HIS A 553
 None
None
ZN  A1751 ( 2.6A)
ZN  A1752 (-3.3A)
 1.09A 5zhmA-1z8lA:
0.6		 5zhmA-1z8lA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 ARG A 212
SER A 382
ASP A 383
HIS A 425
 None
 1.28A 5zhmA-3b0qA:
undetectable		 5zhmA-3b0qA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8e YGHU, GLUTATHIONE
S-TRANSFERASE
HOMOLOGUE

(Escherichia
coli) 		PF02798
(GST_N)
PF13410
(GST_C_2) 		4 ARG A 254
SER A 276
ASP A 274
HIS A  43
 None
 1.41A 5zhmA-3c8eA:
0.5		 5zhmA-3c8eA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3on5 BH1974 PROTEIN

(Bacillus
halodurans) 		PF02625
(XdhC_CoxI)
PF13478
(XdhC_C) 		4 ARG A 323
SER A   2
ASP A   3
HIS A 175
 None
 1.19A 5zhmA-3on5A:
1.0		 5zhmA-3on5A:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rcn BETA-N-ACETYLHEXOSAM
INIDASE

(Paenarthrobacter
aurescens) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b) 		4 ARG A 196
SER A 455
ASP A 143
HIS A 172
 None
 1.39A 5zhmA-3rcnA:
0.0		 5zhmA-3rcnA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w04 DWARF 88 ESTERASE

(Oryza sativa) 		PF12697
(Abhydrolase_6) 		4 ARG A 227
SER A 108
ASP A 102
HIS A  76
 None
 1.34A 5zhmA-3w04A:
1.9		 5zhmA-3w04A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5q CHI1

(Yersinia
entomophaga) 		PF00704
(Glyco_hydro_18) 		4 ARG A  83
SER A 411
ASP A 421
HIS A 425
 None
 1.50A 5zhmA-4a5qA:
0.0		 5zhmA-4a5qA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Toxoplasma
gondii) 		PF00274
(Glycolytic) 		4 ARG A 401
SER A 347
ASP A 350
HIS A 317
 None
 1.49A 5zhmA-4d2jA:
0.2		 5zhmA-4d2jA:
22.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4h3z TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Paraburkholderia
phymatum) 		PF01746
(tRNA_m1G_MT) 		4 ARG A 158
SER A 174
ASP A 181
HIS A 184
 None
 0.67A 5zhmA-4h3zA:
27.1		 5zhmA-4h3zA:
52.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hl7 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Vibrio cholerae) 		PF04095
(NAPRTase) 		4 ARG A 188
SER A 324
ASP A 294
HIS A 232
 None
 1.26A 5zhmA-4hl7A:
undetectable		 5zhmA-4hl7A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mzy NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Enterococcus
faecalis) 		PF04095
(NAPRTase) 		4 ARG A 164
SER A 292
ASP A 264
HIS A 205
 CL  A 518 (-3.9A)
None
FMT  A 520 ( 4.5A)
MLA  A 515 (-3.9A)
 1.27A 5zhmA-4mzyA:
0.3		 5zhmA-4mzyA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nxk ABP, A GH27
BETA-L-ARABINOPYRANO
SIDASE

(Geobacillus
stearothermophilus) 		PF16499
(Melibiase_2) 		4 ARG A  99
SER A  31
ASP A  66
HIS A 126
 None
None
GOL  A 510 (-2.7A)
GOL  A 510 (-3.9A)
 1.27A 5zhmA-4nxkA:
undetectable		 5zhmA-4nxkA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o8m TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Actinobacillus
succinogenes) 		PF03480
(DctP) 		4 ARG A 170
SER A 174
ASP A  91
HIS A 235
 2Q2  A 403 (-3.0A)
None
2Q2  A 403 (-4.2A)
2Q2  A 403 (-3.9A)
 1.27A 5zhmA-4o8mA:
undetectable		 5zhmA-4o8mA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1

(Homo sapiens;
synthetic
construct) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 ARG A3396
SER A3507
ASP A3508
HIS A3574
 None
 1.37A 5zhmA-4rh7A:
undetectable		 5zhmA-4rh7A:
5.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ocl ANTI-LLAMA NANOBODY

(Vicugna pacos) 		PF07686
(V-set) 		4 ARG A  73
SER A  52
ASP A  37
HIS A  98
 None
 1.46A 5zhmA-5oclA:
undetectable		 5zhmA-5oclA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thw DEACYLASE

(Burkholderia
multivorans) 		PF01546
(Peptidase_M20) 		4 ARG A 301
SER A 394
ASP A 107
HIS A  96
 URP  A 503 (-2.9A)
None
ZN  A 502 (-2.4A)
ZN  A 501 ( 3.5A)
 1.45A 5zhmA-5thwA:
1.6		 5zhmA-5thwA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuo GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN

(Novosphingobium
aromaticivorans) 		no annotation 4 ARG B 259
SER B 276
ASP B 274
HIS B  47
 None
 1.37A 5zhmA-5uuoB:
0.6		 5zhmA-5uuoB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wyr TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Pseudomonas
aeruginosa) 		no annotation 4 ARG A 159
SER A 175
ASP A 182
HIS A 185
 None
 0.53A 5zhmA-5wyrA:
25.8		 5zhmA-5wyrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ap6 PROBABLE
STRIGOLACTONE
ESTERASE DAD2

(Petunia x
hybrida) 		no annotation 4 ARG A 176
SER A  57
ASP A  51
HIS A  25
 None
 1.37A 5zhmA-6ap6A:
1.4		 5zhmA-6ap6A:
undetectable