SIMILAR PATTERNS OF AMINO ACIDS FOR 5ZHM_B_SAMB301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkw FE(III)-PYOCHELIN
RECEPTOR

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 ARG A 333
SER A 267
ASP A 266
HIS A 264
 None
 1.49A 5zhmA-1xkwA:
undetectable		 5zhmA-1xkwA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yir NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE 2

(Pseudomonas
aeruginosa) 		PF04095
(NAPRTase) 		4 ARG A 182
SER A 319
ASP A 289
HIS A 226
 SO4  A2002 ( 4.8A)
None
SO4  A2001 ( 4.2A)
SO4  A2001 (-3.7A)
 1.29A 5zhmA-1yirA:
0.0		 5zhmA-1yirA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z8l GLUTAMATE
CARBOXYPEPTIDASE II

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		4 ARG A 534
SER A 454
ASP A 387
HIS A 553
 None
None
ZN  A1751 ( 2.6A)
ZN  A1752 (-3.3A)
 1.09A 5zhmA-1z8lA:
0.6		 5zhmA-1z8lA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 ARG A 212
SER A 382
ASP A 383
HIS A 425
 None
 1.28A 5zhmA-3b0qA:
undetectable		 5zhmA-3b0qA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8e YGHU, GLUTATHIONE
S-TRANSFERASE
HOMOLOGUE

(Escherichia
coli) 		PF02798
(GST_N)
PF13410
(GST_C_2) 		4 ARG A 254
SER A 276
ASP A 274
HIS A  43
 None
 1.41A 5zhmA-3c8eA:
0.5		 5zhmA-3c8eA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3on5 BH1974 PROTEIN

(Bacillus
halodurans) 		PF02625
(XdhC_CoxI)
PF13478
(XdhC_C) 		4 ARG A 323
SER A   2
ASP A   3
HIS A 175
 None
 1.19A 5zhmA-3on5A:
1.0		 5zhmA-3on5A:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rcn BETA-N-ACETYLHEXOSAM
INIDASE

(Paenarthrobacter
aurescens) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b) 		4 ARG A 196
SER A 455
ASP A 143
HIS A 172
 None
 1.39A 5zhmA-3rcnA:
0.0		 5zhmA-3rcnA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w04 DWARF 88 ESTERASE

(Oryza sativa) 		PF12697
(Abhydrolase_6) 		4 ARG A 227
SER A 108
ASP A 102
HIS A  76
 None
 1.34A 5zhmA-3w04A:
1.9		 5zhmA-3w04A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5q CHI1

(Yersinia
entomophaga) 		PF00704
(Glyco_hydro_18) 		4 ARG A  83
SER A 411
ASP A 421
HIS A 425
 None
 1.50A 5zhmA-4a5qA:
0.0		 5zhmA-4a5qA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Toxoplasma
gondii) 		PF00274
(Glycolytic) 		4 ARG A 401
SER A 347
ASP A 350
HIS A 317
 None
 1.49A 5zhmA-4d2jA:
0.2		 5zhmA-4d2jA:
22.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4h3z TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Paraburkholderia
phymatum) 		PF01746
(tRNA_m1G_MT) 		4 ARG A 158
SER A 174
ASP A 181
HIS A 184
 None
 0.67A 5zhmA-4h3zA:
27.1		 5zhmA-4h3zA:
52.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hl7 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Vibrio cholerae) 		PF04095
(NAPRTase) 		4 ARG A 188
SER A 324
ASP A 294
HIS A 232
 None
 1.26A 5zhmA-4hl7A:
undetectable		 5zhmA-4hl7A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mzy NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Enterococcus
faecalis) 		PF04095
(NAPRTase) 		4 ARG A 164
SER A 292
ASP A 264
HIS A 205
 CL  A 518 (-3.9A)
None
FMT  A 520 ( 4.5A)
MLA  A 515 (-3.9A)
 1.27A 5zhmA-4mzyA:
0.3		 5zhmA-4mzyA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nxk ABP, A GH27
BETA-L-ARABINOPYRANO
SIDASE

(Geobacillus
stearothermophilus) 		PF16499
(Melibiase_2) 		4 ARG A  99
SER A  31
ASP A  66
HIS A 126
 None
None
GOL  A 510 (-2.7A)
GOL  A 510 (-3.9A)
 1.27A 5zhmA-4nxkA:
undetectable		 5zhmA-4nxkA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o8m TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Actinobacillus
succinogenes) 		PF03480
(DctP) 		4 ARG A 170
SER A 174
ASP A  91
HIS A 235
 2Q2  A 403 (-3.0A)
None
2Q2  A 403 (-4.2A)
2Q2  A 403 (-3.9A)
 1.27A 5zhmA-4o8mA:
undetectable		 5zhmA-4o8mA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1

(Homo sapiens;
synthetic
construct) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 ARG A3396
SER A3507
ASP A3508
HIS A3574
 None
 1.37A 5zhmA-4rh7A:
undetectable		 5zhmA-4rh7A:
5.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ocl ANTI-LLAMA NANOBODY

(Vicugna pacos) 		PF07686
(V-set) 		4 ARG A  73
SER A  52
ASP A  37
HIS A  98
 None
 1.46A 5zhmA-5oclA:
undetectable		 5zhmA-5oclA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thw DEACYLASE

(Burkholderia
multivorans) 		PF01546
(Peptidase_M20) 		4 ARG A 301
SER A 394
ASP A 107
HIS A  96
 URP  A 503 (-2.9A)
None
ZN  A 502 (-2.4A)
ZN  A 501 ( 3.5A)
 1.45A 5zhmA-5thwA:
1.6		 5zhmA-5thwA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuo GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN

(Novosphingobium
aromaticivorans) 		no annotation 4 ARG B 259
SER B 276
ASP B 274
HIS B  47
 None
 1.37A 5zhmA-5uuoB:
0.6		 5zhmA-5uuoB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wyr TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Pseudomonas
aeruginosa) 		no annotation 4 ARG A 159
SER A 175
ASP A 182
HIS A 185
 None
 0.53A 5zhmA-5wyrA:
25.8		 5zhmA-5wyrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ap6 PROBABLE
STRIGOLACTONE
ESTERASE DAD2

(Petunia x
hybrida) 		no annotation 4 ARG A 176
SER A  57
ASP A  51
HIS A  25
 None
 1.37A 5zhmA-6ap6A:
1.4		 5zhmA-6ap6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a88 CHLOROPEROXIDASE L

(Streptomyces
lividans) 		PF00561
(Abhydrolase_1) 		6 GLY A  29
VAL A 120
LEU A 119
GLY A  99
GLY A 100
PRO A 124
 None
 1.30A 5zhmB-1a88A:
2.5		 5zhmB-1a88A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4x PROTEIN
(2-HYDROXY-6-OXO-6-P
HENYLHEXA-2,4-DIENOA
TE HYDROLASE)

(Rhodococcus
jostii) 		PF12697
(Abhydrolase_6) 		5 LEU A 132
ILE A 106
LEU A  34
GLY A 112
GLY A 113
 None
 0.89A 5zhmB-1c4xA:
2.2		 5zhmB-1c4xA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cbf COBALT-PRECORRIN-4
TRANSMETHYLASE

(Bacillus
megaterium) 		PF00590
(TP_methylase) 		6 LEU A  35
GLY A 129
VAL A 133
GLY A 102
GLY A  29
PRO A  30
 None
None
None
SAH  A 300 (-3.5A)
None
SAH  A 300 (-4.9A)
 1.35A 5zhmB-1cbfA:
3.0		 5zhmB-1cbfA:
24.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo sapiens) 		PF00080
(Sod_Cu) 		5 GLY A 203
GLY A 222
ILE A 119
LEU A 129
GLY A 128
 None
 0.80A 5zhmB-1do5A:
undetectable		 5zhmB-1do5A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dub 2-ENOYL-COA
HYDRATASE

(Rattus
norvegicus) 		PF00378
(ECH_1) 		6 GLY A 140
GLY A 175
ILE A  66
LEU A 145
GLY A 142
GLY A 141
 CAA  A 300 (-3.1A)
None
None
None
None
CAA  A 300 (-3.6A)
 1.40A 5zhmB-1dubA:
undetectable		 5zhmB-1dubA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gxk CHROMOSOME
SEGREGATION SMC
PROTEIN

(Thermotoga
maritima) 		PF06470
(SMC_hinge) 		5 GLY A 615
ILE A 576
LEU A 609
GLY A 610
GLY A 611
 None
 0.89A 5zhmB-1gxkA:
undetectable		 5zhmB-1gxkA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3j PEROXIDASE

(Coprinopsis
cinerea) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		6 GLY A  73
GLY A 283
LEU A  64
GLY A  71
GLY A  72
PRO A 148
 None
 1.30A 5zhmB-1h3jA:
undetectable		 5zhmB-1h3jA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hyl HYPODERMA LINEATUM
COLLAGENASE

(Hypoderma
lineatum) 		PF00089
(Trypsin) 		5 GLY A 196
SER A 189
ILE A  17
GLY A 193
GLY A 142
 None
 0.90A 5zhmB-1hylA:
undetectable		 5zhmB-1hylA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nbw GLYCEROL DEHYDRATASE
REACTIVASE ALPHA
SUBUNIT

(Klebsiella
pneumoniae) 		PF08841
(DDR) 		6 GLY A 417
GLU A 461
GLY A 441
LEU A 562
GLY A 559
GLY A 558
 None
 1.25A 5zhmB-1nbwA:
undetectable		 5zhmB-1nbwA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nbw GLYCEROL DEHYDRATASE
REACTIVASE ALPHA
SUBUNIT

(Klebsiella
pneumoniae) 		PF08841
(DDR) 		6 LEU A 556
GLY A 584
GLY A 591
SER A 560
ILE A 566
PRO A 567
 None
 1.40A 5zhmB-1nbwA:
undetectable		 5zhmB-1nbwA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ns5 HYPOTHETICAL PROTEIN
YBEA

(Escherichia
coli) 		PF02590
(SPOUT_MTase) 		5 LEU A  72
GLY A 103
GLY A 107
SER A 121
LEU A 127
 None
 0.79A 5zhmB-1ns5A:
10.8		 5zhmB-1ns5A:
22.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1oy5 TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Aquifex
aeolicus) 		PF01746
(tRNA_m1G_MT) 		6 GLY A 115
GLU A 118
GLY A 119
LEU A 139
GLY A 141
GLY A 142
 None
 0.76A 5zhmB-1oy5A:
22.5		 5zhmB-1oy5A:
37.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1p9p TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Escherichia
coli) 		PF01746
(tRNA_m1G_MT) 		12 LEU A  87
PRO A  89
GLY A 113
GLU A 116
GLY A 117
SER A 132
ILE A 133
VAL A 137
LEU A 138
GLY A 140
GLY A 141
PRO A 144
 SAH  A 300 (-4.4A)
SAH  A 300 (-3.8A)
SAH  A 300 (-3.2A)
None
SAH  A 300 (-3.6A)
SAH  A 300 (-3.6A)
SAH  A 300 (-4.4A)
SAH  A 300 ( 4.0A)
SAH  A 300 (-4.1A)
SAH  A 300 (-3.1A)
SAH  A 300 (-3.5A)
SAH  A 300 (-4.5A)
 0.52A 5zhmB-1p9pA:
28.6		 5zhmB-1p9pA:
61.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1p9p TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Escherichia
coli) 		PF01746
(tRNA_m1G_MT) 		6 PRO A  89
GLY A 113
GLU A 116
GLY A 117
LEU A 138
GLY A 141
 SAH  A 300 (-3.8A)
SAH  A 300 (-3.2A)
None
SAH  A 300 (-3.6A)
SAH  A 300 (-4.1A)
SAH  A 300 (-3.5A)
 1.30A 5zhmB-1p9pA:
28.6		 5zhmB-1p9pA:
61.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1p9p TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Escherichia
coli) 		PF01746
(tRNA_m1G_MT) 		6 PRO A  89
GLY A 113
GLY A 117
LEU A 138
GLY A 140
PRO A 144
 SAH  A 300 (-3.8A)
SAH  A 300 (-3.2A)
SAH  A 300 (-3.6A)
SAH  A 300 (-4.1A)
SAH  A 300 (-3.1A)
SAH  A 300 (-4.5A)
 1.19A 5zhmB-1p9pA:
28.6		 5zhmB-1p9pA:
61.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qpa LIGNIN PEROXIDASE

(Phanerochaete
chrysosporium) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		6 GLY A  65
GLY A 276
LEU A  56
GLY A  63
GLY A  64
PRO A 140
 None
 1.30A 5zhmB-1qpaA:
undetectable		 5zhmB-1qpaA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t70 PHOSPHATASE

(Deinococcus
radiodurans) 		PF13277
(YmdB) 		5 GLY A  11
GLY A  42
ILE A   6
GLY A 198
GLY A  14
 None
 0.87A 5zhmB-1t70A:
undetectable		 5zhmB-1t70A:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1to6 GLYCERATE KINASE

(Neisseria
meningitidis) 		PF02595
(Gly_kinase) 		6 LEU A 189
GLY A 130
SER A 261
ILE A 263
GLY A  45
GLY A  44
 None
 1.46A 5zhmB-1to6A:
2.0		 5zhmB-1to6A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tzb GLUCOSE-6-PHOSPHATE
ISOMERASE,
CONJECTURAL

(Pyrobaculum
aerophilum) 		PF10432
(bact-PGI_C) 		5 GLY A  49
SER A  89
GLY A  46
GLY A  47
PRO A 134
 None
SO4  A 709 (-3.1A)
None
SO4  A 709 ( 4.8A)
SO4  A 709 (-4.2A)
 0.90A 5zhmB-1tzbA:
2.0		 5zhmB-1tzbA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uou THYMIDINE
PHOSPHORYLASE

(Homo sapiens) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		5 GLY A 147
GLY A 149
SER A 117
VAL A 121
GLY A 153
 CMU  A1481 ( 4.9A)
None
CMU  A1481 (-4.3A)
None
CMU  A1481 ( 4.1A)
 0.86A 5zhmB-1uouA:
2.2		 5zhmB-1uouA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urh 3-MERCAPTOPYRUVATE
SULFURTRANSFERASE

(Escherichia
coli) 		PF00581
(Rhodanese) 		5 LEU A 122
GLY A  95
ILE A  46
VAL A  91
GLY A 121
 None
 0.86A 5zhmB-1urhA:
undetectable		 5zhmB-1urhA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vg0 RAB PROTEINS
GERANYLGERANYLTRANSF
ERASE COMPONENT A 1

(Rattus
norvegicus) 		PF00996
(GDI) 		6 PRO A 575
GLY A  45
SER A 573
LEU A  18
GLY A  17
PRO A  19
 None
 1.45A 5zhmB-1vg0A:
undetectable		 5zhmB-1vg0A:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wac P2 PROTEIN

(Pseudomonas
virus phi6) 		PF00680
(RdRP_1) 		5 GLY A 394
GLY A 396
SER A 149
GLY A 275
GLY A 274
 None
 0.78A 5zhmB-1wacA:
undetectable		 5zhmB-1wacA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xa0 PUTATIVE NADPH
DEPENDENT
OXIDOREDUCTASES

(Geobacillus
stearothermophilus) 		PF00107
(ADH_zinc_N) 		5 LEU A 136
GLY A 246
VAL A 242
LEU A 268
GLY A 269
 None
 0.88A 5zhmB-1xa0A:
undetectable		 5zhmB-1xa0A:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yb5 QUINONE
OXIDOREDUCTASE

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 156
GLY A 162
ILE A 218
LEU A 177
GLY A 178
 NAP  A 801 ( 3.1A)
CL  A 816 (-3.3A)
None
None
None
 0.86A 5zhmB-1yb5A:
undetectable		 5zhmB-1yb5A:
27.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bx7 DIHYDROOROTATE
DEHYDROGENASE

(Lactococcus
lactis) 		PF01180
(DHO_dh) 		5 GLY A 218
GLY A 220
LEU A 199
GLY A 198
GLY A 217
 None
FMN  A1312 ( 3.8A)
None
None
None
 0.90A 5zhmB-2bx7A:
undetectable		 5zhmB-2bx7A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3t FATTY OXIDATION
COMPLEX ALPHA
SUBUNIT

(Pseudomonas
fragi) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 LEU A 115
GLY A  68
ILE A 136
GLY A 117
GLY A 116
 None
 0.89A 5zhmB-2d3tA:
undetectable		 5zhmB-2d3tA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4y FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 1

(Salmonella
enterica) 		no annotation 5 LEU A 279
GLY A 277
ILE A 161
GLY A 281
GLY A 280
 None
 0.84A 5zhmB-2d4yA:
undetectable		 5zhmB-2d4yA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d74 TRANSLATION
INITIATION FACTOR 2
BETA SUBUNIT

(Pyrococcus
furiosus) 		PF01873
(eIF-5_eIF-2B) 		5 GLY B  41
ILE B  93
VAL B  83
LEU B  84
GLY B  86
 None
 0.88A 5zhmB-2d74B:
undetectable		 5zhmB-2d74B:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eq9 PYRUVATE
DEHYDROGENASE
COMPLEX,
DIHYDROLIPOAMIDE
DEHYDROGENASE E3
COMPONENT

(Thermus
thermophilus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		6 LEU A 106
GLY A 104
GLU A  39
LEU A  99
GLY A 101
GLY A 102
 None
None
FAD  A8482 (-2.7A)
None
None
None
 1.21A 5zhmB-2eq9A:
undetectable		 5zhmB-2eq9A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eq9 PYRUVATE
DEHYDROGENASE
COMPLEX,
DIHYDROLIPOAMIDE
DEHYDROGENASE E3
COMPONENT

(Thermus
thermophilus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		6 LEU A 106
GLY A 104
GLU A  42
LEU A  99
GLY A 101
GLY A 102
 None
 1.50A 5zhmB-2eq9A:
undetectable		 5zhmB-2eq9A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gzs IROE PROTEIN

(Escherichia
coli) 		PF00756
(Esterase) 		5 PRO A 136
GLY A 216
SER A 157
GLY A 192
GLY A 191
 None
DFP  A1189 (-3.6A)
None
None
None
 0.81A 5zhmB-2gzsA:
2.7		 5zhmB-2gzsA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hfs MEVALONATE KINASE,
PUTATIVE

(Leishmania
major) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		6 GLY A 287
GLU A  24
GLY A 284
ILE A 316
VAL A 290
GLY A 191
 None
 1.38A 5zhmB-2hfsA:
undetectable		 5zhmB-2hfsA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0w LYSINE-SENSITIVE
ASPARTOKINASE 3

(Escherichia
coli) 		PF00696
(AA_kinase)
PF01842
(ACT) 		5 PRO A 261
GLY A 197
GLY A 357
GLY A 199
GLY A 200
 None
None
None
ASP  A 502 (-3.1A)
ASP  A 502 (-4.2A)
 0.68A 5zhmB-2j0wA:
undetectable		 5zhmB-2j0wA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kl3 ALR3790 PROTEIN

(Nostoc sp. PCC
7120) 		PF00581
(Rhodanese) 		6 LEU A  94
GLY A  68
ILE A  37
LEU A  90
GLY A  92
GLY A  93
 None
 1.40A 5zhmB-2kl3A:
undetectable		 5zhmB-2kl3A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kl3 ALR3790 PROTEIN

(Nostoc sp. PCC
7120) 		PF00581
(Rhodanese) 		6 LEU A  94
GLY A  68
ILE A  37
VAL A  64
LEU A  90
GLY A  93
 None
 1.23A 5zhmB-2kl3A:
undetectable		 5zhmB-2kl3A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lbw H/ACA
RIBONUCLEOPROTEIN
COMPLEX SUBUNIT 2

(Saccharomyces
cerevisiae) 		PF01248
(Ribosomal_L7Ae) 		5 LEU A 110
GLY A 114
SER A 121
ILE A  81
GLY A 111
 None
 0.89A 5zhmB-2lbwA:
undetectable		 5zhmB-2lbwA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odl ADHESIN

(Haemophilus
influenzae) 		PF05860
(Haemagg_act) 		5 LEU A 343
GLY A 348
GLY A 383
SER A 315
GLY A 323
 None
 0.88A 5zhmB-2odlA:
undetectable		 5zhmB-2odlA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qmi PBP RELATED
BETA-LACTAMASE

(Pyrococcus
abyssi) 		PF00144
(Beta-lactamase)
PF13969
(Pab87_oct) 		6 LEU A 237
GLY A  58
GLY A 304
ILE A 184
GLY A 235
GLY A 236
 None
 1.28A 5zhmB-2qmiA:
undetectable		 5zhmB-2qmiA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qmm UPF0217 PROTEIN
AF_1056

(Archaeoglobus
fulgidus) 		PF04013
(Methyltrn_RNA_2) 		5 LEU A 221
GLY A 242
GLY A 246
SER A 264
LEU A 270
 SAM  A 301 (-4.3A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.3A)
SAM  A 301 (-3.4A)
SAM  A 301 (-4.5A)
 0.78A 5zhmB-2qmmA:
8.4		 5zhmB-2qmmA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qru UNCHARACTERIZED
PROTEIN

(Enterococcus
faecalis) 		PF07859
(Abhydrolase_3) 		6 GLY A 104
GLY A  33
SER A 227
ILE A 230
GLY A 100
GLY A 105
 None
PO4  A 273 ( 3.7A)
None
None
None
None
 1.38A 5zhmB-2qruA:
undetectable		 5zhmB-2qruA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT) 		5 GLY G 511
GLY G 513
ILE G 244
GLY G 508
GLY G 507
 None
 0.77A 5zhmB-2uv8G:
undetectable		 5zhmB-2uv8G:
8.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT

(Clostridium
scatologenes) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		5 PRO A 757
GLY A 640
GLY A 539
ILE A 885
VAL A 399
 None
 0.89A 5zhmB-2y8nA:
undetectable		 5zhmB-2y8nA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1q ACYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 LEU A 505
ILE A 575
LEU A 502
GLY A 503
GLY A 504
 None
 0.86A 5zhmB-2z1qA:
undetectable		 5zhmB-2z1qA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwq CAPSID PROTEIN VP1

(Macaca mulatta
polyomavirus 1) 		PF00718
(Polyoma_coat) 		5 LEU A 290
ILE A 288
VAL A 243
LEU A 244
GLY A 251
 None
 0.88A 5zhmB-3bwqA:
undetectable		 5zhmB-3bwqA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8z CYSTEINYL-TRNA
SYNTHETASE

(Mycolicibacterium
smegmatis) 		PF01406
(tRNA-synt_1e) 		5 LEU A  60
GLY A 281
ILE A 313
LEU A  53
GLY A  54
 None
None
None
None
5CA  A 418 (-3.3A)
 0.87A 5zhmB-3c8zA:
undetectable		 5zhmB-3c8zA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ce1 SUPEROXIDE DISMUTASE
[CU-ZN]

(Naganishia
liquefaciens) 		PF00080
(Sod_Cu) 		5 GLY A 126
GLY A 145
ILE A  38
VAL A 122
GLY A  48
 None
 0.82A 5zhmB-3ce1A:
undetectable		 5zhmB-3ce1A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3chx PMOB

(Methylosinus
trichosporium) 		PF04744
(Monooxygenase_B) 		5 PRO A 420
ILE A 399
LEU A 299
GLY A 301
GLY A 302
 None
 0.87A 5zhmB-3chxA:
undetectable		 5zhmB-3chxA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwc PUTATIVE GLYCERATE
KINASE 2

(Salmonella
enterica) 		PF02595
(Gly_kinase) 		5 GLY A 248
GLU A 202
GLY A 203
GLY A 246
GLY A 247
 None
 0.87A 5zhmB-3cwcA:
undetectable		 5zhmB-3cwcA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dcp HISTIDINOL-PHOSPHATA
SE

(Listeria
monocytogenes) 		PF02811
(PHP)
PF13263
(PHP_C) 		5 GLY A 127
GLU A 143
GLY A 144
GLY A 129
GLY A 130
 None
 0.79A 5zhmB-3dcpA:
undetectable		 5zhmB-3dcpA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddm PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Bordetella
bronchiseptica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		6 LEU A 282
PRO A 280
GLY A 286
GLY A 262
GLY A 290
GLY A 287
 None
 1.44A 5zhmB-3ddmA:
undetectable		 5zhmB-3ddmA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dtn PUTATIVE
METHYLTRANSFERASE
MM_2633

(Methanosarcina
mazei) 		PF13649
(Methyltransf_25) 		6 GLY A  52
GLY A  54
ILE A 117
VAL A 112
LEU A  49
GLY A  50
 None
 1.15A 5zhmB-3dtnA:
undetectable		 5zhmB-3dtnA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eg4 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E

(Brucella suis) 		PF00132
(Hexapep)
PF14602
(Hexapep_2)
PF14805
(THDPS_N_2) 		5 LEU A 165
ILE A 185
VAL A 208
LEU A 209
GLY A 192
 None
 0.85A 5zhmB-3eg4A:
undetectable		 5zhmB-3eg4A:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3frk QDTB

(Thermoanaerobacterium
thermosaccharolyticum) 		PF01041
(DegT_DnrJ_EryC1) 		6 GLY A  60
GLY A 179
SER A 212
LEU A 231
GLY A 195
GLY A  58
 TQP  A 374 (-3.2A)
None
None
None
None
None
 1.40A 5zhmB-3frkA:
undetectable		 5zhmB-3frkA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli) 		PF01134
(GIDA)
PF13932
(GIDA_assoc) 		6 LEU A 316
PRO A 263
GLU A 344
LEU A 167
GLY A 166
PRO A 317
 None
 1.47A 5zhmB-3g05A:
undetectable		 5zhmB-3g05A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyq RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE

(Streptomyces
cyaneus) 		PF00588
(SpoU_methylase)
PF04705
(TSNR_N) 		5 LEU A 195
GLY A 218
GLY A 223
SER A 237
ILE A 238
 SAM  A 270 (-4.1A)
SAM  A 270 (-2.9A)
None
SAM  A 270 (-4.3A)
SAM  A 270 (-3.5A)
 0.86A 5zhmB-3gyqA:
7.7		 5zhmB-3gyqA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hix ALR3790 PROTEIN

(Nostoc sp. PCC
7120) 		PF00581
(Rhodanese) 		5 LEU A 109
ILE A  52
VAL A  79
LEU A 105
GLY A 108
 None
 0.78A 5zhmB-3hixA:
undetectable		 5zhmB-3hixA:
21.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ief TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Bartonella
henselae) 		PF01746
(tRNA_m1G_MT) 		6 PRO A  87
GLY A 111
GLY A 115
SER A 130
ILE A 131
LEU A 136
 None
 0.74A 5zhmB-3iefA:
22.3		 5zhmB-3iefA:
41.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ief TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Bartonella
henselae) 		PF01746
(tRNA_m1G_MT) 		7 PRO A  87
GLY A 111
SER A 130
ILE A 131
LEU A 136
GLY A 138
GLY A 139
 None
 0.48A 5zhmB-3iefA:
22.3		 5zhmB-3iefA:
41.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jtx AMINOTRANSFERASE

(Neisseria
meningitidis) 		PF00155
(Aminotran_1_2) 		6 GLY A 370
SER A 180
LEU A 358
GLY A 355
GLY A 368
PRO A 127
 None
 1.40A 5zhmB-3jtxA:
undetectable		 5zhmB-3jtxA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jux PROTEIN TRANSLOCASE
SUBUNIT SECA

(Thermotoga
maritima) 		PF00271
(Helicase_C)
PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		6 LEU A 550
GLY A 578
LEU A 547
GLY A 548
GLY A 549
PRO A 476
 None
 1.33A 5zhmB-3juxA:
undetectable		 5zhmB-3juxA:
15.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3knu TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Anaplasma
phagocytophilum) 		PF01746
(tRNA_m1G_MT) 		10 PRO A  88
GLY A 112
GLU A 115
GLY A 116
SER A 131
ILE A 132
VAL A 136
LEU A 137
GLY A 139
GLY A 140
 None
 0.63A 5zhmB-3knuA:
24.3		 5zhmB-3knuA:
41.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ky7 TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Staphylococcus
aureus) 		PF01746
(tRNA_m1G_MT) 		7 PRO A  87
GLY A 111
SER A 130
LEU A 136
GLY A 138
GLY A 139
PRO A 142
 OCS  A  86 ( 2.5A)
None
OCS  A  86 ( 3.8A)
None
None
None
None
 0.74A 5zhmB-3ky7A:
10.9		 5zhmB-3ky7A:
45.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ky7 TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Staphylococcus
aureus) 		PF01746
(tRNA_m1G_MT) 		7 PRO A  87
SER A 130
VAL A 135
LEU A 136
GLY A 138
GLY A 139
PRO A 142
 OCS  A  86 ( 2.5A)
OCS  A  86 ( 3.8A)
None
None
None
None
None
 0.67A 5zhmB-3ky7A:
10.9		 5zhmB-3ky7A:
45.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpz GET4 (YOR164C
HOMOLOG)

(Chaetomium
thermophilum) 		PF04190
(DUF410) 		6 GLY A  64
GLY A  62
VAL A  54
LEU A  70
GLY A  67
GLY A  68
 None
 1.44A 5zhmB-3lpzA:
undetectable		 5zhmB-3lpzA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmz PUTATIVE HAD FAMILY
HYDROLASE

(Streptomyces
avermitilis) 		PF08282
(Hydrolase_3) 		6 GLY A  43
GLU A 153
GLY A 149
ILE A  78
GLY A  47
GLY A  45
 None
None
None
None
None
CL  A 503 ( 3.8A)
 1.27A 5zhmB-3mmzA:
2.1		 5zhmB-3mmzA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nk7 23S RRNA
METHYLTRANSFERASE

(Streptomyces
actuosus) 		PF00588
(SpoU_methylase)
PF04705
(TSNR_N) 		6 LEU A 195
GLY A 218
GLY A 223
SER A 237
ILE A 238
LEU A 247
 SAM  A 770 (-3.8A)
SAM  A 770 (-3.0A)
SAM  A 770 (-3.4A)
None
SAM  A 770 (-3.8A)
SAM  A 770 (-4.5A)
 1.17A 5zhmB-3nk7A:
7.4		 5zhmB-3nk7A:
25.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwy URIDYLATE KINASE

(Mycobacterium
tuberculosis) 		PF00696
(AA_kinase) 		6 GLY A  78
SER A 108
VAL A  74
LEU A  37
GLY A  38
GLY A  39
 None
 1.16A 5zhmB-3nwyA:
undetectable		 5zhmB-3nwyA:
26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oix PUTATIVE
DIHYDROOROTATE
DEHYDROGENASE
DIHYDROOROTATE
OXIDASE

(Streptococcus
mutans) 		PF01180
(DHO_dh) 		5 GLY A 217
GLY A 219
LEU A 200
GLY A 199
GLY A 216
 None
FMN  A 400 (-3.7A)
None
None
None
 0.87A 5zhmB-3oixA:
undetectable		 5zhmB-3oixA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3out GLUTAMATE RACEMASE

(Francisella
tularensis) 		PF01177
(Asp_Glu_race) 		5 GLY A  13
GLY A  36
VAL A  20
GLY A  16
GLY A  15
 DGL  A 266 (-4.6A)
None
None
None
None
 0.88A 5zhmB-3outA:
4.3		 5zhmB-3outA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Legionella
pneumophila) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		6 LEU A 448
GLY A 131
GLU A 162
SER A 439
GLY A 126
GLY A 127
 None
None
ZN  A 501 (-3.9A)
IMD  A 513 ( 4.6A)
None
None
 1.26A 5zhmB-3pfeA:
undetectable		 5zhmB-3pfeA:
19.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qsg NAD-BINDING
PHOSPHOGLUCONATE
DEHYDROGENASE-LIKE
PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF03807
(F420_oxidored)
PF09130
(DUF1932) 		5 GLU A 156
LEU A 167
GLY A 164
GLY A 163
PRO A  97
 None
 0.90A 5zhmB-3qsgA:
2.1		 5zhmB-3qsgA:
30.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3quv TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Mycobacteroides
abscessus) 		PF01746
(tRNA_m1G_MT) 		6 PRO A  85
GLU A 112
GLY A 113
ILE A 133
LEU A 138
GLY A 141
 EDO  A 243 (-3.7A)
None
EDO  A 244 (-3.4A)
None
EDO  A 243 (-4.0A)
EDO  A 243 (-3.6A)
 1.21A 5zhmB-3quvA:
22.2		 5zhmB-3quvA:
40.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3quv TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Mycobacteroides
abscessus) 		PF01746
(tRNA_m1G_MT) 		6 PRO A  85
GLU A 112
GLY A 113
ILE A 133
VAL A 137
LEU A 138
 EDO  A 243 (-3.7A)
None
EDO  A 244 (-3.4A)
None
None
EDO  A 243 (-4.0A)
 1.23A 5zhmB-3quvA:
22.2		 5zhmB-3quvA:
40.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3quv TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Mycobacteroides
abscessus) 		PF01746
(tRNA_m1G_MT) 		6 PRO A  85
GLY A 109
GLY A 113
ILE A 133
LEU A 138
GLY A 141
 EDO  A 243 (-3.7A)
EDO  A 244 ( 4.1A)
EDO  A 244 (-3.4A)
None
EDO  A 243 (-4.0A)
EDO  A 243 (-3.6A)
 1.26A 5zhmB-3quvA:
22.2		 5zhmB-3quvA:
40.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3quv TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Mycobacteroides
abscessus) 		PF01746
(tRNA_m1G_MT) 		9 PRO A  85
GLY A 109
GLY A 113
SER A 132
ILE A 133
VAL A 137
LEU A 138
GLY A 140
GLY A 141
 EDO  A 243 (-3.7A)
EDO  A 244 ( 4.1A)
EDO  A 244 (-3.4A)
None
None
None
EDO  A 243 (-4.0A)
EDO  A 243 (-4.1A)
EDO  A 243 (-3.6A)
 0.73A 5zhmB-3quvA:
22.2		 5zhmB-3quvA:
40.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s2u UDP-N-ACETYLGLUCOSAM
INE--N-ACETYLMURAMYL
-(PENTAPEPTIDE)
PYROPHOSPHORYL-UNDEC
APRENOL
N-ACETYLGLUCOSAMINE
TRANSFERASE

(Pseudomonas
aeruginosa) 		PF03033
(Glyco_transf_28)
PF04101
(Glyco_tran_28_C) 		6 LEU A  99
GLY A  10
GLY A  37
ILE A 120
GLY A 101
GLY A 100
 None
 0.95A 5zhmB-3s2uA:
undetectable		 5zhmB-3s2uA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vi3 INTEGRIN ALPHA-5

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		5 LEU A 394
GLY A 390
SER A 396
GLY A 392
GLY A 393
 None
 0.88A 5zhmB-3vi3A:
undetectable		 5zhmB-3vi3A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zei O-ACETYLSERINE
SULFHYDRYLASE

(Mycobacterium
tuberculosis) 		PF00291
(PALP) 		6 PRO A 204
GLY A 178
GLY A 222
ILE A 240
VAL A 243
GLY A 176
 None
PLP  A1301 (-3.6A)
PLP  A1301 ( 3.5A)
None
None
None
 1.47A 5zhmB-3zeiA:
undetectable		 5zhmB-3zeiA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zh2 L-LACTATE
DEHYDROGENASE

(Plasmodium
falciparum) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 GLY A  13
ILE A 243
VAL A 237
GLY A  17
GLY A  16
 None
 0.83A 5zhmB-3zh2A:
2.3		 5zhmB-3zh2A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a69 HISTONE DEACETYLASE
3,

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		6 GLY A 257
ILE A 150
VAL A 292
LEU A 293
GLY A 294
GLY A 295
 None
 1.20A 5zhmB-4a69A:
undetectable		 5zhmB-4a69A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a69 HISTONE DEACETYLASE
3,

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		6 GLY A 296
ILE A 150
VAL A 292
LEU A 293
GLY A 294
GLY A 295
 ACT  A 501 (-3.0A)
None
None
None
None
None
 1.36A 5zhmB-4a69A:
undetectable		 5zhmB-4a69A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bm1 MANGANESE PEROXIDASE
4

(Pleurotus
ostreatus) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		6 GLY A  66
GLY A 276
LEU A  57
GLY A  64
GLY A  65
PRO A 141
 None
 1.33A 5zhmB-4bm1A:
undetectable		 5zhmB-4bm1A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN ALPHA-IIB

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		5 GLY A 290
GLY A 256
VAL A 295
LEU A 307
GLY A 309
 None
 0.80A 5zhmB-4cakA:
undetectable		 5zhmB-4cakA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cze ROD
SHAPE-DETERMINING
PROTEIN MREB

(Caulobacter
vibrioides) 		PF06723
(MreB_Mbl) 		6 GLY A 164
GLY A 187
LEU A 298
GLY A 295
GLY A 294
PRO A 320
 PO4  A1334 (-3.5A)
None
None
None
None
None
 1.20A 5zhmB-4czeA:
undetectable		 5zhmB-4czeA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dcm RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G

(Escherichia
coli) 		PF05175
(MTS) 		5 GLY A 240
GLY A 238
ILE A 232
LEU A 303
GLY A 243
 None
SAM  A 401 ( 3.7A)
None
None
None
 0.90A 5zhmB-4dcmA:
undetectable		 5zhmB-4dcmA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dy0 GLIA-DERIVED NEXIN

(Homo sapiens) 		PF00079
(Serpin) 		5 GLY A 374
SER A 233
ILE A 232
VAL A 370
LEU A 371
 None
 0.86A 5zhmB-4dy0A:
undetectable		 5zhmB-4dy0A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fff LEVAN
FRUCTOTRANSFERASE

(Paenarthrobacter
ureafaciens) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		5 GLY A 392
SER A 412
ILE A 411
VAL A 387
LEU A 388
 None
 0.89A 5zhmB-4fffA:
undetectable		 5zhmB-4fffA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1

(Saccharomyces
cerevisiae) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 GLU A 171
GLY A 174
SER A 346
ILE A 347
GLY A 387
 GLY  A 503 (-3.2A)
None
None
None
None
 0.77A 5zhmB-4g1pA:
undetectable		 5zhmB-4g1pA:
19.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4h3z TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Paraburkholderia
phymatum) 		PF01746
(tRNA_m1G_MT) 		9 PRO A  93
GLY A 117
GLU A 120
SER A 136
VAL A 141
LEU A 142
GLY A 144
GLY A 145
PRO A 148
 SAH  A 301 (-3.7A)
SAH  A 301 (-3.5A)
SAH  A 301 (-3.5A)
SAH  A 301 (-3.4A)
SAH  A 301 (-3.9A)
SAH  A 301 (-4.3A)
SAH  A 301 (-3.1A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.4A)
 0.42A 5zhmB-4h3zA:
26.5		 5zhmB-4h3zA:
52.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4izd ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN

(Ruegeria
pomeroyi) 		PF00378
(ECH_1) 		6 LEU A  71
GLY A 117
ILE A  40
LEU A 122
GLY A 119
GLY A 118
 None
 1.45A 5zhmB-4izdA:
undetectable		 5zhmB-4izdA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jbh ALCOHOL
DEHYDROGENASE (ZINC)

(Pyrobaculum
aerophilum) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 245
VAL A 275
LEU A 274
GLY A 248
GLY A 247
 None
 0.85A 5zhmB-4jbhA:
undetectable		 5zhmB-4jbhA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgn CELLULOSE-BINDING,
FAMILY II

(Acidothermus
cellulolyticus) 		no annotation 5 GLY A  87
GLY A  98
SER A  71
GLY A 120
GLY A 121
 None
 0.75A 5zhmB-4lgnA:
undetectable		 5zhmB-4lgnA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mj0 VP1 CAPSID PROTEIN

(Human
polyomavirus 1) 		PF00718
(Polyoma_coat) 		5 LEU A 290
ILE A 288
VAL A 243
LEU A 244
GLY A 251
 None
 0.88A 5zhmB-4mj0A:
undetectable		 5zhmB-4mj0A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mla CYTOKININ OXIDASE 2

(Zea mays) 		PF01565
(FAD_binding_4)
PF09265
(Cytokin-bind) 		6 GLY A 136
GLY A  97
ILE A 229
LEU A 168
GLY A 165
GLY A 135
 None
FAD  A 601 (-3.4A)
None
None
FAD  A 601 (-3.6A)
FAD  A 601 ( 4.4A)
 1.48A 5zhmB-4mlaA:
undetectable		 5zhmB-4mlaA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oic PROBABLE PROTEIN
PHOSPHATASE 2C 6

(Oryza sativa) 		PF00481
(PP2C) 		6 LEU B 348
PRO B 320
GLY B 341
SER B 351
ILE B 363
GLY B 346
 None
 1.36A 5zhmB-4oicB:
undetectable		 5zhmB-4oicB:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oou BETA-1,4-MANNANASE

(Cryptopygus
antarcticus) 		no annotation 6 LEU B 186
GLY B 184
GLU B  87
GLY B 134
GLY B 209
GLY B 207
 None
 1.38A 5zhmB-4oouB:
undetectable		 5zhmB-4oouB:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p9n CARBOXYLESTERASE

(Sulfolobus
shibatae) 		PF07859
(Abhydrolase_3) 		5 LEU A 175
ILE A 147
LEU A  77
GLY A 153
GLY A 154
 None
 0.79A 5zhmB-4p9nA:
2.5		 5zhmB-4p9nA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pve POLLEN ALLERGEN PHL
P 4.0202

(Phleum pratense) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 GLY A 161
GLY A 157
SER A 492
ILE A 493
GLY A 207
 None
FAD  A 601 (-3.1A)
None
None
None
 0.82A 5zhmB-4pveA:
undetectable		 5zhmB-4pveA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qww ACETYLCHOLINESTERASE

(Bungarus
fasciatus) 		PF00135
(COesterase) 		5 LEU A 156
PRO A 165
GLY A 154
GLY A 169
LEU A  46
 None
 0.89A 5zhmB-4qwwA:
undetectable		 5zhmB-4qwwA:
20.36