SIMILAR PATTERNS OF AMINO ACIDS FOR 5ZCQ_W_CHDW101

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d02 TYPE II RESTRICTION
ENZYME MUNI

(Mycoplasma) 		PF11407
(RestrictionMunI) 		4 ILE A  86
LEU A  42
PHE A  35
LEU A 189
 None
 0.94A 5zcqN-1d02A:
undetectable
5zcqW-1d02A:
undetectable		 5zcqN-1d02A:
17.47
5zcqW-1d02A:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus 1) 		PF00078
(RVT_1) 		4 LEU A 109
MET A 164
THR A 165
LEU A 168
 None
 0.72A 5zcqN-1harA:
undetectable
5zcqW-1harA:
0.1		 5zcqN-1harA:
18.00
5zcqW-1harA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jed SULFATE
ADENYLYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 ILE A  48
LEU A  49
THR A  38
LEU A  37
 None
 0.78A 5zcqN-1jedA:
0.0
5zcqW-1jedA:
0.0		 5zcqN-1jedA:
21.17
5zcqW-1jedA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01063
(Aminotran_4) 		4 ILE A 332
MET A 293
THR A 292
LEU A 235
 None
 0.86A 5zcqN-1kt8A:
0.0
5zcqW-1kt8A:
0.0		 5zcqN-1kt8A:
22.71
5zcqW-1kt8A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mc8 FLAP ENDONUCLEASE-1

(Pyrococcus
horikoshii) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		4 ILE A   5
LEU A   8
ARG A 223
THR A 222
 None
 0.90A 5zcqN-1mc8A:
0.0
5zcqW-1mc8A:
undetectable		 5zcqN-1mc8A:
20.59
5zcqW-1mc8A:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nc7 HYPOTHETICAL PROTEIN
TM1070

(Thermotoga
maritima) 		PF07100
(ASRT) 		4 ILE A  42
PHE A  44
ARG A  67
LEU A  93
 None
 0.94A 5zcqN-1nc7A:
undetectable
5zcqW-1nc7A:
0.0		 5zcqN-1nc7A:
13.09
5zcqW-1nc7A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odo PUTATIVE CYTOCHROME
P450 154A1

(Streptomyces
coelicolor) 		PF00067
(p450) 		4 PHE A 106
MET A 210
THR A 211
LEU A 214
 HEM  A1407 (-4.5A)
None
None
None
 0.89A 5zcqN-1odoA:
0.0
5zcqW-1odoA:
0.0		 5zcqN-1odoA:
23.13
5zcqW-1odoA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ozn RETICULON 4 RECEPTOR

(Homo sapiens) 		PF13855
(LRR_8) 		4 LEU A 112
ARG A  61
THR A  84
LEU A 107
 None
 0.90A 5zcqN-1oznA:
undetectable
5zcqW-1oznA:
0.0		 5zcqN-1oznA:
19.64
5zcqW-1oznA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6x ATP:SULFATE
ADENYLYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 ILE A  48
LEU A  49
THR A  38
LEU A  37
 None
 0.76A 5zcqN-1r6xA:
0.0
5zcqW-1r6xA:
0.0		 5zcqN-1r6xA:
21.48
5zcqW-1r6xA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ska 3-PHYTASE A

(Aspergillus
fumigatus) 		PF00328
(His_Phos_2) 		4 LEU A 261
PHE A 262
THR A 230
LEU A 229
 None
 0.83A 5zcqN-1skaA:
0.0
5zcqW-1skaA:
undetectable		 5zcqN-1skaA:
19.89
5zcqW-1skaA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdh NEI ENDONUCLEASE
VIII-LIKE 1

(Homo sapiens) 		PF01149
(Fapy_DNA_glyco)
PF06831
(H2TH)
PF09292
(Neil1-DNA_bind) 		4 ILE A  47
LEU A 112
PHE A 101
LEU A  56
 None
 0.95A 5zcqN-1tdhA:
undetectable
5zcqW-1tdhA:
undetectable		 5zcqN-1tdhA:
20.00
5zcqW-1tdhA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhf PERIPLASMIC DIVALENT
CATION TOLERANCE
PROTEIN

(Thermotoga
maritima) 		PF03091
(CutA1) 		4 ILE A  17
PHE A   8
ARG A  70
LEU A  65
 None
 0.95A 5zcqN-1vhfA:
undetectable
5zcqW-1vhfA:
undetectable		 5zcqN-1vhfA:
11.13
5zcqW-1vhfA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w1k VANILLYL-ALCOHOL
OXIDASE

(Penicillium
simplicissimum) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		4 ILE A 250
LEU A 253
ARG A 211
LEU A 204
 None
 0.82A 5zcqN-1w1kA:
0.0
5zcqW-1w1kA:
undetectable		 5zcqN-1w1kA:
22.15
5zcqW-1w1kA:
6.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zv4 REGULATOR OF
G-PROTEIN SIGNALING
17

(Homo sapiens) 		PF00615
(RGS) 		4 ILE X 178
LEU X 181
ARG X  95
LEU X 102
 None
 0.82A 5zcqN-1zv4X:
undetectable
5zcqW-1zv4X:
undetectable		 5zcqN-1zv4X:
13.67
5zcqW-1zv4X:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2be7 ASPARTATE
CARBAMOYLTRANSFERASE
CATALYTIC CHAIN
ASPARTATE
CARBAMOYLTRANSFERASE
REGULATORY CHAIN

(Moritella
profunda;
Moritella
profunda) 		PF00185
(OTCace)
PF02729
(OTCace_N)
PF01948
(PyrI)
PF02748
(PyrI_C) 		4 ILE D 114
LEU A 115
ARG A 106
MET A 105
 None
 0.89A 5zcqN-2be7D:
undetectable
5zcqW-2be7D:
undetectable		 5zcqN-2be7D:
17.43
5zcqW-2be7D:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bwg GMP REDUCTASE I

(Homo sapiens) 		PF00478
(IMPDH) 		4 ILE A 154
MET A 113
THR A 114
LEU A 117
 None
 0.94A 5zcqN-2bwgA:
undetectable
5zcqW-2bwgA:
undetectable		 5zcqN-2bwgA:
21.02
5zcqW-2bwgA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cph RNA BINDING MOTIF
PROTEIN 19

(Mus musculus) 		PF00076
(RRM_1) 		4 ILE A 478
LEU A 481
PHE A 482
ARG A 467
 None
 0.86A 5zcqN-2cphA:
undetectable
5zcqW-2cphA:
undetectable		 5zcqN-2cphA:
12.76
5zcqW-2cphA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3z C2 TOXIN COMPONENT I

(Clostridium
botulinum) 		PF03496
(ADPrib_exo_Tox) 		4 LEU A  89
ARG A  28
THR A  31
LEU A  33
 None
 0.94A 5zcqN-2j3zA:
undetectable
5zcqW-2j3zA:
undetectable		 5zcqN-2j3zA:
19.36
5zcqW-2j3zA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jzn MANNOSE-SPECIFIC
PHOSPHOTRANSFERASE
ENZYME IIA COMPONENT

(Escherichia
coli) 		PF03610
(EIIA-man) 		4 ILE A   3
LEU A 114
PHE A 111
LEU A  65
 None
 0.89A 5zcqN-2jznA:
undetectable
5zcqW-2jznA:
undetectable		 5zcqN-2jznA:
15.94
5zcqW-2jznA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6q VARIABLE LYMPHOCYTE
RECEPTOR A

(Eptatretus
burgeri) 		PF13855
(LRR_8) 		4 ILE A  53
PHE A  79
THR A  97
LEU A  95
 None
 0.96A 5zcqN-2o6qA:
undetectable
5zcqW-2o6qA:
undetectable		 5zcqN-2o6qA:
18.29
5zcqW-2o6qA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozg GCN5-RELATED
N-ACETYLTRANSFERASE

(Trichormus
variabilis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		4 ILE A  25
LEU A  22
ARG A  54
LEU A  99
 None
 0.88A 5zcqN-2ozgA:
undetectable
5zcqW-2ozgA:
undetectable		 5zcqN-2ozgA:
21.72
5zcqW-2ozgA:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0d RHO
GTPASE-ACTIVATING
PROTEIN 9

(Homo sapiens) 		PF00169
(PH) 		4 ILE A 405
LEU A 390
THR A 353
LEU A 352
 None
 0.77A 5zcqN-2p0dA:
undetectable
5zcqW-2p0dA:
undetectable		 5zcqN-2p0dA:
12.67
5zcqW-2p0dA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE X 252
MET X 356
THR X 357
LEU X 360
 None
 0.83A 5zcqN-2p3gX:
undetectable
5zcqW-2p3gX:
undetectable		 5zcqN-2p3gX:
19.81
5zcqW-2p3gX:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q7s N-FORMYLGLUTAMATE
AMIDOHYDROLASE

(Cupriavidus
pinatubonensis) 		PF05013
(FGase) 		4 ILE A 250
PHE A 192
ARG A 272
THR A 275
 None
 0.90A 5zcqN-2q7sA:
undetectable
5zcqW-2q7sA:
undetectable		 5zcqN-2q7sA:
19.19
5zcqW-2q7sA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qk4 TRIFUNCTIONAL PURINE
BIOSYNTHETIC PROTEIN
ADENOSINE-3

(Homo sapiens) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 ILE A 272
PHE A 203
THR A  16
LEU A  17
 None
 0.87A 5zcqN-2qk4A:
undetectable
5zcqW-2qk4A:
undetectable		 5zcqN-2qk4A:
22.52
5zcqW-2qk4A:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uvf EXOPOLYGALACTURONASE

(Yersinia
enterocolitica) 		PF00295
(Glyco_hydro_28)
PF12708
(Pectate_lyase_3) 		4 PHE A 347
MET A 334
THR A 335
LEU A 336
 None
 0.91A 5zcqN-2uvfA:
undetectable
5zcqW-2uvfA:
undetectable		 5zcqN-2uvfA:
22.56
5zcqW-2uvfA:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3c TOXIC EXTRACELLULAR
ENDOPEPTIDASE

(Aeromonas
salmonicida) 		PF14521
(Aspzincin_M35) 		4 LEU A  67
PHE A  68
THR A  43
LEU A  44
 None
 0.82A 5zcqN-2x3cA:
undetectable
5zcqW-2x3cA:
undetectable		 5zcqN-2x3cA:
20.64
5zcqW-2x3cA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y69 CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1

(Bos taurus) 		PF02238
(COX7a) 		4 TYR J  32
MET J  36
THR J  37
LEU J  40
 None
 0.06A 5zcqN-2y69J:
undetectable
5zcqW-2y69J:
7.9		 5zcqN-2y69J:
10.31
5zcqW-2y69J:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yrf METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE

(Bacillus
subtilis) 		PF01008
(IF-2B) 		4 ILE A 343
LEU A 346
PHE A 347
ARG A 241
 None
 0.95A 5zcqN-2yrfA:
undetectable
5zcqW-2yrfA:
undetectable		 5zcqN-2yrfA:
20.95
5zcqW-2yrfA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ze0 ALPHA-GLUCOSIDASE

(Geobacillus sp.
HTA-462) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 ILE A 193
LEU A  97
PHE A 196
MET A 184
 None
 0.79A 5zcqN-2ze0A:
undetectable
5zcqW-2ze0A:
undetectable		 5zcqN-2ze0A:
19.59
5zcqW-2ze0A:
7.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zts PUTATIVE
UNCHARACTERIZED
PROTEIN PH0186

(Pyrococcus
horikoshii) 		PF06745
(ATPase) 		4 ILE A 127
PHE A 123
THR A 178
LEU A 177
 None
 0.70A 5zcqN-2ztsA:
undetectable
5zcqW-2ztsA:
undetectable		 5zcqN-2ztsA:
17.81
5zcqW-2ztsA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b7y E3 UBIQUITIN-PROTEIN
LIGASE NEDD4

(Homo sapiens) 		PF00168
(C2) 		5 PHE A 189
ARG A 124
MET A 248
THR A 249
LEU A 213
 None
 1.36A 5zcqN-3b7yA:
undetectable
5zcqW-3b7yA:
undetectable		 5zcqN-3b7yA:
13.39
5zcqW-3b7yA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b7y E3 UBIQUITIN-PROTEIN
LIGASE NEDD4

(Homo sapiens) 		PF00168
(C2) 		5 PHE A 229
ARG A 124
MET A 248
THR A 249
LEU A 213
 None
 1.50A 5zcqN-3b7yA:
undetectable
5zcqW-3b7yA:
undetectable		 5zcqN-3b7yA:
13.39
5zcqW-3b7yA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c9b VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 75

(Saccharomyces
cerevisiae) 		PF00956
(NAP) 		4 ILE A  80
LEU A  62
ARG A  73
LEU A 200
 None
 0.68A 5zcqN-3c9bA:
undetectable
5zcqW-3c9bA:
undetectable		 5zcqN-3c9bA:
16.41
5zcqW-3c9bA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dby UNCHARACTERIZED
PROTEIN

(Bacillus cereus) 		PF11155
(DUF2935) 		4 LEU A  53
PHE A  50
ARG A  77
LEU A 115
 None
 0.89A 5zcqN-3dbyA:
2.1
5zcqW-3dbyA:
undetectable		 5zcqN-3dbyA:
17.09
5zcqW-3dbyA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dcp HISTIDINOL-PHOSPHATA
SE

(Listeria
monocytogenes) 		PF02811
(PHP)
PF13263
(PHP_C) 		4 LEU A  30
PHE A  32
TYR A 255
THR A 271
 None
 0.77A 5zcqN-3dcpA:
undetectable
5zcqW-3dcpA:
undetectable		 5zcqN-3dcpA:
19.37
5zcqW-3dcpA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fss HISTONE CHAPERONE
RTT106

(Saccharomyces
cerevisiae) 		PF08512
(Rtt106) 		4 ILE A 200
MET A 158
THR A 159
LEU A 160
 None
 0.94A 5zcqN-3fssA:
undetectable
5zcqW-3fssA:
undetectable		 5zcqN-3fssA:
19.04
5zcqW-3fssA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gju PUTATIVE
AMINOTRANSFERASE

(Mesorhizobium
japonicum) 		PF00202
(Aminotran_3) 		4 ILE A 131
MET A 159
THR A 160
LEU A 163
 None
 0.89A 5zcqN-3gjuA:
undetectable
5zcqW-3gjuA:
undetectable		 5zcqN-3gjuA:
22.26
5zcqW-3gjuA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzy BIPHENYL DIOXYGENASE
SUBUNIT BETA

(Comamonas
testosteroni) 		PF00866
(Ring_hydroxyl_B) 		4 ILE B 165
LEU B  48
ARG B  31
LEU B  36
 None
 0.91A 5zcqN-3gzyB:
undetectable
5zcqW-3gzyB:
undetectable		 5zcqN-3gzyB:
15.34
5zcqW-3gzyB:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iqd OCTOPINE
DEHYDROGENASE

(Pecten maximus) 		PF02317
(Octopine_DH) 		4 LEU B 184
PHE B 194
THR B  16
LEU B  17
 None
 0.92A 5zcqN-3iqdB:
undetectable
5zcqW-3iqdB:
undetectable		 5zcqN-3iqdB:
21.05
5zcqW-3iqdB:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4p CAPSID PROTEIN VP1

(Adeno-associated
virus) 		PF00740
(Parvo_coat) 		4 ILE A 374
LEU A 249
ARG A 245
LEU A 317
 None
 0.83A 5zcqN-3j4pA:
undetectable
5zcqW-3j4pA:
undetectable		 5zcqN-3j4pA:
22.36
5zcqW-3j4pA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4u MAJOR CAPSID PROTEIN

(Bordetella
virus BPP1) 		no annotation 4 ILE A  38
LEU A 130
PHE A 131
LEU A 183
 None
 0.92A 5zcqN-3j4uA:
undetectable
5zcqW-3j4uA:
undetectable		 5zcqN-3j4uA:
21.07
5zcqW-3j4uA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE

(Cupriavidus
pinatubonensis) 		PF00465
(Fe-ADH) 		4 ILE A 343
LEU A 346
ARG A 322
LEU A 248
 None
 0.80A 5zcqN-3jzdA:
2.3
5zcqW-3jzdA:
undetectable		 5zcqN-3jzdA:
22.15
5zcqW-3jzdA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k13 5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE

(Bacteroides
thetaiotaomicron) 		PF00809
(Pterin_bind) 		4 ARG A 407
MET A 410
THR A 411
LEU A 414
 None
 0.58A 5zcqN-3k13A:
undetectable
5zcqW-3k13A:
undetectable		 5zcqN-3k13A:
20.20
5zcqW-3k13A:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfu ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B

(Thermus
thermophilus) 		PF02637
(GatB_Yqey)
PF02934
(GatB_N) 		4 ILE F 166
LEU F 163
ARG F 111
LEU F 153
 None
 0.95A 5zcqN-3kfuF:
undetectable
5zcqW-3kfuF:
undetectable		 5zcqN-3kfuF:
18.69
5zcqW-3kfuF:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kuq RHO
GTPASE-ACTIVATING
PROTEIN 7

(Homo sapiens) 		PF00620
(RhoGAP) 		4 ILE A1186
PHE A1170
ARG A1198
LEU A1205
 None
 0.77A 5zcqN-3kuqA:
undetectable
5zcqW-3kuqA:
undetectable		 5zcqN-3kuqA:
17.51
5zcqW-3kuqA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lrk ALPHA-GALACTOSIDASE
1

(Saccharomyces
cerevisiae) 		PF16499
(Melibiase_2) 		4 ILE A  69
LEU A 103
PHE A 108
ARG A  55
 None
 0.94A 5zcqN-3lrkA:
undetectable
5zcqW-3lrkA:
undetectable		 5zcqN-3lrkA:
20.99
5zcqW-3lrkA:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3muu STRUCTURAL
POLYPROTEIN

(Sindbis virus) 		PF00943
(Alpha_E2_glycop)
PF01589
(Alpha_E1_glycop) 		4 ILE A 283
ARG A 298
THR A 296
LEU A 295
 None
 0.93A 5zcqN-3muuA:
undetectable
5zcqW-3muuA:
undetectable		 5zcqN-3muuA:
21.45
5zcqW-3muuA:
6.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3owt DNA-BINDING PROTEIN
RAP1

(Saccharomyces
cerevisiae) 		PF11626
(Rap1_C) 		4 ILE A 746
PHE A 769
THR A 756
LEU A 755
 None
 0.87A 5zcqN-3owtA:
undetectable
5zcqW-3owtA:
undetectable		 5zcqN-3owtA:
13.87
5zcqW-3owtA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8c NCK-ASSOCIATED
PROTEIN 1

(Homo sapiens) 		PF09735
(Nckap1) 		4 LEU B 682
ARG B 705
THR B 709
LEU B 712
 None
 0.76A 5zcqN-3p8cB:
1.6
5zcqW-3p8cB:
undetectable		 5zcqN-3p8cB:
18.35
5zcqW-3p8cB:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pf2 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
agalactiae) 		PF16569
(GramPos_pilinBB)
PF16570
(GramPos_pilinD3) 		4 ILE A 236
LEU A 240
THR A 270
LEU A 271
 None
 0.77A 5zcqN-3pf2A:
undetectable
5zcqW-3pf2A:
undetectable		 5zcqN-3pf2A:
18.65
5zcqW-3pf2A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q0x CENTRIOLE PROTEIN

(Chlamydomonas
reinhardtii) 		PF16531
(SAS-6_N) 		4 LEU A 153
PHE A 155
ARG A  48
LEU A  63
 None
 0.87A 5zcqN-3q0xA:
undetectable
5zcqW-3q0xA:
2.8		 5zcqN-3q0xA:
16.90
5zcqW-3q0xA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rr1 PUTATIVE
D-GALACTONATE
DEHYDRATASE

(Ralstonia
pickettii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A  93
LEU A  90
THR A   7
LEU A   6
 None
 0.73A 5zcqN-3rr1A:
undetectable
5zcqW-3rr1A:
undetectable		 5zcqN-3rr1A:
22.10
5zcqW-3rr1A:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3se7 VANA

(-) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 TYR A 315
MET A 319
THR A 320
LEU A 324
 None
 0.94A 5zcqN-3se7A:
undetectable
5zcqW-3se7A:
undetectable		 5zcqN-3se7A:
21.97
5zcqW-3se7A:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v85 CYTH-LIKE
PHOSPHATASE

(Arabidopsis
thaliana) 		PF01928
(CYTH) 		4 ILE A 191
LEU A 186
THR A  23
LEU A  22
 None
 0.93A 5zcqN-3v85A:
undetectable
5zcqW-3v85A:
undetectable		 5zcqN-3v85A:
17.05
5zcqW-3v85A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3we7 PUTATIVE
UNCHARACTERIZED
PROTEIN PH0499

(Pyrococcus
horikoshii) 		PF02585
(PIG-L) 		4 ILE A 192
ARG A 125
THR A 129
LEU A 132
 None
 0.83A 5zcqN-3we7A:
undetectable
5zcqW-3we7A:
undetectable		 5zcqN-3we7A:
18.46
5zcqW-3we7A:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES

(Mycolicibacterium
smegmatis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 ILE A 318
LEU A 506
ARG A 311
LEU A 390
 None
 0.93A 5zcqN-3zo9A:
undetectable
5zcqW-3zo9A:
undetectable		 5zcqN-3zo9A:
21.46
5zcqW-3zo9A:
7.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8c GLUCOSE-REPRESSIBLE
ALCOHOL
DEHYDROGENASE
TRANSCRIPTIONAL
EFFECTOR

(Saccharomyces
cerevisiae) 		PF03372
(Exo_endo_phos)
PF13855
(LRR_8) 		4 ILE D 376
LEU D 399
THR D 370
LEU D 392
 None
 0.85A 5zcqN-4b8cD:
undetectable
5zcqW-4b8cD:
undetectable		 5zcqN-4b8cD:
21.05
5zcqW-4b8cD:
6.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bjt DNA-BINDING PROTEIN
RAP1

(Saccharomyces
cerevisiae) 		PF11626
(Rap1_C) 		4 ILE A 746
PHE A 769
THR A 756
LEU A 755
 None
 0.94A 5zcqN-4bjtA:
undetectable
5zcqW-4bjtA:
undetectable		 5zcqN-4bjtA:
18.11
5zcqW-4bjtA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bob ERPP PROTEIN

(Borreliella
burgdorferi) 		PF02471
(OspE) 		4 PHE A  78
MET A  92
THR A  93
LEU A 160
 None
 0.80A 5zcqN-4bobA:
undetectable
5zcqW-4bobA:
undetectable		 5zcqN-4bobA:
15.65
5zcqW-4bobA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxm ERPC

(Borreliella
burgdorferi) 		PF02471
(OspE) 		4 PHE A  73
MET A  87
THR A  88
LEU A 153
 None
 0.81A 5zcqN-4bxmA:
undetectable
5zcqW-4bxmA:
undetectable		 5zcqN-4bxmA:
15.42
5zcqW-4bxmA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f9l 20.1 ANTI-BTN3A1
ANTIBODY FRAGMENT

(Mus musculus) 		no annotation 4 LEU D 142
ARG D 171
THR D 218
LEU D 217
 None
 0.94A 5zcqN-4f9lD:
undetectable
5zcqW-4f9lD:
undetectable		 5zcqN-4f9lD:
18.81
5zcqW-4f9lD:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdd TRANSPORTIN-1

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		4 ILE A 440
ARG A 464
THR A 506
LEU A 507
 None
 0.89A 5zcqN-4fddA:
2.5
5zcqW-4fddA:
undetectable		 5zcqN-4fddA:
20.07
5zcqW-4fddA:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hk1 PROLIFERATING CELL
NUCLEAR ANTIGEN

(Drosophila
melanogaster) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 ILE A  11
ARG A  53
THR A  51
LEU A  50
 None
 0.88A 5zcqN-4hk1A:
undetectable
5zcqW-4hk1A:
undetectable		 5zcqN-4hk1A:
19.03
5zcqW-4hk1A:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htf S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE

(Escherichia
coli) 		PF13847
(Methyltransf_31) 		4 ILE B 116
LEU B 135
THR B 111
LEU B 109
 None
 0.93A 5zcqN-4htfB:
undetectable
5zcqW-4htfB:
undetectable		 5zcqN-4htfB:
18.97
5zcqW-4htfB:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc5 RHIE PROTEIN

(Paraburkholderia
rhizoxinica) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 ILE A3361
LEU A3395
PHE A3446
ARG A3345
 None
 0.95A 5zcqN-4kc5A:
undetectable
5zcqW-4kc5A:
undetectable		 5zcqN-4kc5A:
19.34
5zcqW-4kc5A:
4.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kem MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Azospirillum
lipoferum) 		PF13378
(MR_MLE_C) 		4 LEU A 275
ARG A 303
MET A 307
LEU A 308
 None
 0.85A 5zcqN-4kemA:
undetectable
5zcqW-4kemA:
undetectable		 5zcqN-4kemA:
21.75
5zcqW-4kemA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l37 ARYLPHORIN

(Bombyx mori) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 ILE B 512
LEU B 537
PHE B 558
LEU B 452
 None
 0.95A 5zcqN-4l37B:
undetectable
5zcqW-4l37B:
undetectable		 5zcqN-4l37B:
18.83
5zcqW-4l37B:
6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5p UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF09994
(DUF2235) 		4 ILE A 272
LEU A 326
PHE A 325
THR A 303
 None
 0.91A 5zcqN-4o5pA:
0.4
5zcqW-4o5pA:
undetectable		 5zcqN-4o5pA:
19.53
5zcqW-4o5pA:
5.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4om9 SERINE PROTEASE PET

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		4 ILE A 662
LEU A 683
THR A 674
LEU A 672
 None
 0.74A 5zcqN-4om9A:
undetectable
5zcqW-4om9A:
undetectable		 5zcqN-4om9A:
19.71
5zcqW-4om9A:
5.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqf PROTEIN RECA

(Mycobacterium
tuberculosis) 		PF00154
(RecA) 		4 ILE A 144
MET A 179
THR A 180
LEU A 183
 None
 0.82A 5zcqN-4oqfA:
undetectable
5zcqW-4oqfA:
undetectable		 5zcqN-4oqfA:
20.15
5zcqW-4oqfA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p8s RETICULON-4
RECEPTOR-LIKE 2

(Rattus
norvegicus) 		PF13855
(LRR_8) 		4 LEU A 258
ARG A 207
THR A 230
LEU A 253
 None
 0.95A 5zcqN-4p8sA:
undetectable
5zcqW-4p8sA:
undetectable		 5zcqN-4p8sA:
18.85
5zcqW-4p8sA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pk1 CHIMERA PROTEIN OF
OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTORS BAMA AND
BAMB

(Escherichia
coli) 		PF07244
(POTRA)
PF13360
(PQQ_2) 		4 ILE A1349
PHE A1356
ARG A1304
LEU A1327
 None
 0.89A 5zcqN-4pk1A:
undetectable
5zcqW-4pk1A:
undetectable		 5zcqN-4pk1A:
21.54
5zcqW-4pk1A:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qbu ZMAA

(Bacillus cereus) 		PF00698
(Acyl_transf_1) 		4 ILE A 189
LEU A  98
ARG A 363
LEU A 386
 None
 0.89A 5zcqN-4qbuA:
undetectable
5zcqW-4qbuA:
undetectable		 5zcqN-4qbuA:
20.36
5zcqW-4qbuA:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rwt LEIOMODIN-2

(Homo sapiens) 		no annotation 4 ARG C 309
MET C 312
THR C 313
LEU C 316
 None
 0.65A 5zcqN-4rwtC:
undetectable
5zcqW-4rwtC:
undetectable		 5zcqN-4rwtC:
19.44
5zcqW-4rwtC:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8p TALIN-1
AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING
FAMILY B MEMBER
1-INTERACTING
PROTEIN

(Mus musculus;
Mus musculus) 		no annotation
no annotation 		4 LEU B  15
PHE B  12
THR A1562
LEU A1565
 EDO  A1701 ( 4.8A)
None
None
None
 0.93A 5zcqN-4w8pB:
undetectable
5zcqW-4w8pB:
undetectable		 5zcqN-4w8pB:
6.75
5zcqW-4w8pB:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y21 PROTEIN UNC-13
HOMOLOG A

(Rattus
norvegicus) 		PF06292
(DUF1041)
PF10540
(Membr_traf_MHD) 		4 LEU A 277
PHE A 274
ARG A 344
LEU A 367
 None
 0.87A 5zcqN-4y21A:
undetectable
5zcqW-4y21A:
undetectable		 5zcqN-4y21A:
21.36
5zcqW-4y21A:
7.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynh SPINDLE ASSEMBLY
ABNORMAL PROTEIN 5

(Caenorhabditis
elegans) 		no annotation 4 ILE A 247
LEU A 237
PHE A 243
LEU A 230
 None
 0.79A 5zcqN-4ynhA:
undetectable
5zcqW-4ynhA:
undetectable		 5zcqN-4ynhA:
8.11
5zcqW-4ynhA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A

(Oryctolagus
cuniculus) 		PF01399
(PCI) 		4 ILE A 484
LEU A 491
PHE A 452
LEU A 440
 None
 0.91A 5zcqN-5a5tA:
undetectable
5zcqW-5a5tA:
undetectable		 5zcqN-5a5tA:
13.37
5zcqW-5a5tA:
5.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aeu BIPHENYL DIOXYGENASE
SUBUNIT BETA

(Paraburkholderia
xenovorans) 		PF00866
(Ring_hydroxyl_B) 		4 ILE B 167
LEU B  50
ARG B  33
LEU B  38
 None
 0.93A 5zcqN-5aeuB:
undetectable
5zcqW-5aeuB:
undetectable		 5zcqN-5aeuB:
15.05
5zcqW-5aeuB:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bu6 BPSB (PGAB),
POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE

(Bordetella
bronchiseptica) 		PF01522
(Polysacc_deac_1) 		4 ILE A  93
ARG A 289
THR A 273
LEU A 272
 None
 0.89A 5zcqN-5bu6A:
undetectable
5zcqW-5bu6A:
undetectable		 5zcqN-5bu6A:
18.29
5zcqW-5bu6A:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c9e SEPL

(Escherichia
coli) 		PF07201
(HrpJ) 		4 LEU A 315
PHE A 312
THR A 290
LEU A 289
 None
 0.84A 5zcqN-5c9eA:
2.4
5zcqW-5c9eA:
undetectable		 5zcqN-5c9eA:
19.39
5zcqW-5c9eA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ed8 MKIAA0668 PROTEIN

(Mus musculus) 		PF07738
(Sad1_UNC) 		4 ILE A 630
PHE A 661
ARG A 692
LEU A 597
 None
 0.77A 5zcqN-5ed8A:
undetectable
5zcqW-5ed8A:
undetectable		 5zcqN-5ed8A:
19.08
5zcqW-5ed8A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzy (R)-2-HALOACID
DEHALOGENASE

(Pseudomonas
putida) 		PF10778
(DehI) 		4 ILE A 126
PHE A 127
ARG A 211
MET A 176
 None
 0.84A 5zcqN-5gzyA:
1.6
5zcqW-5gzyA:
undetectable		 5zcqN-5gzyA:
20.49
5zcqW-5gzyA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h2t TREHALOSE SYNTHASE

(Thermomonospora
curvata) 		no annotation 4 ILE A 305
LEU A 493
ARG A 298
LEU A 377
 None
 0.79A 5zcqN-5h2tA:
undetectable
5zcqW-5h2tA:
undetectable		 5zcqN-5h2tA:
20.56
5zcqW-5h2tA:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2q EF-HAND
DOMAIN-CONTAINING
PROTEIN D2

(Homo sapiens) 		PF13405
(EF-hand_6) 		4 ILE A 156
LEU A 171
MET A 121
LEU A 117
 None
 0.89A 5zcqN-5i2qA:
undetectable
5zcqW-5i2qA:
undetectable		 5zcqN-5i2qA:
11.61
5zcqW-5i2qA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jw7 E3 UBIQUITIN-PROTEIN
LIGASE TRIM56

(Homo sapiens) 		PF13445
(zf-RING_UBOX) 		4 ILE B  23
LEU B  48
THR B  33
LEU B  34
 None
 0.70A 5zcqN-5jw7B:
undetectable
5zcqW-5jw7B:
undetectable		 5zcqN-5jw7B:
10.76
5zcqW-5jw7B:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jwf ASP/GLU-SPECIFIC
DIPEPTIDYL-PEPTIDASE

(Porphyromonas
gingivalis) 		PF10459
(Peptidase_S46) 		4 ILE A 703
LEU A 700
THR A  82
LEU A  81
 None
 0.82A 5zcqN-5jwfA:
0.5
5zcqW-5jwfA:
undetectable		 5zcqN-5jwfA:
20.60
5zcqW-5jwfA:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxk ASP/GLU-SPECIFIC
DIPEPTIDYL-PEPTIDASE

(Porphyromonas
endodontalis) 		PF10459
(Peptidase_S46) 		4 ILE A 700
LEU A 697
THR A  82
LEU A  81
 None
 0.80A 5zcqN-5jxkA:
1.4
5zcqW-5jxkA:
undetectable		 5zcqN-5jxkA:
18.80
5zcqW-5jxkA:
5.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqm GLYCOSYL HYDROLASES
FAMILY 2, SUGAR
BINDING DOMAIN

(Bacteroides
thetaiotaomicron) 		PF17132
(Glyco_hydro_106) 		4 ILE A 155
LEU A 158
THR A 370
LEU A 175
 None
 0.78A 5zcqN-5mqmA:
undetectable
5zcqW-5mqmA:
undetectable		 5zcqN-5mqmA:
19.15
5zcqW-5mqmA:
4.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nbq OUTER SURFACE
PROTEIN E

(Borreliella
burgdorferi) 		no annotation 4 PHE G  86
MET G 100
THR G 101
LEU G 166
 None
 0.86A 5zcqN-5nbqG:
undetectable
5zcqW-5nbqG:
undetectable		 5zcqN-5nbqG:
undetectable
5zcqW-5nbqG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ny0 L. REUTERIS SRRP
BINDING REGION

(Lactobacillus
reuteri) 		no annotation 4 ILE A 427
MET A 477
THR A 476
LEU A 475
 None
 0.83A 5zcqN-5ny0A:
undetectable
5zcqW-5ny0A:
undetectable		 5zcqN-5ny0A:
undetectable
5zcqW-5ny0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0l RETICULON-4 RECEPTOR

(Mus musculus) 		no annotation 4 LEU A 112
ARG A  61
THR A  84
LEU A 107
 None
 0.82A 5zcqN-5o0lA:
undetectable
5zcqW-5o0lA:
undetectable		 5zcqN-5o0lA:
20.26
5zcqW-5o0lA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tpw GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2A

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		4 ILE B 127
PHE B 147
THR B 300
LEU B 299
 None
 0.83A 5zcqN-5tpwB:
undetectable
5zcqW-5tpwB:
undetectable		 5zcqN-5tpwB:
20.58
5zcqW-5tpwB:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vob ENVELOPE
GLYCOPROTEIN UL128

(Human
betaherpesvirus
5) 		no annotation 4 ILE C 109
LEU C 103
THR C  85
LEU C  84
 None
 0.84A 5zcqN-5vobC:
undetectable
5zcqW-5vobC:
undetectable		 5zcqN-5vobC:
14.92
5zcqW-5vobC:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wug BETA-GLUCOSIDASE

(Paenibacillus
barengoltzii) 		no annotation 4 LEU A 243
TYR A  76
ARG A  78
LEU A 591
 None
 0.93A 5zcqN-5wugA:
undetectable
5zcqW-5wugA:
undetectable		 5zcqN-5wugA:
undetectable
5zcqW-5wugA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xag TUBULIN TYROSINE
LIGASE

(Gallus gallus) 		no annotation 4 ILE F 201
LEU F 221
THR F 278
LEU F 271
 None
 0.81A 5zcqN-5xagF:
undetectable
5zcqW-5xagF:
undetectable		 5zcqN-5xagF:
undetectable
5zcqW-5xagF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xe0 GENOME POLYPROTEIN

(Enterovirus D) 		PF00680
(RdRP_1) 		4 ILE A 291
PHE A 194
TYR A  77
LEU A 249
 None
 0.94A 5zcqN-5xe0A:
undetectable
5zcqW-5xe0A:
undetectable		 5zcqN-5xe0A:
20.98
5zcqW-5xe0A:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xu1 ABC TRANSPORTER
ATP-BINDING PROTEIN

(Streptococcus
pneumoniae) 		no annotation 4 ILE A  88
LEU A 167
PHE A  90
THR A  59
 None
 0.78A 5zcqN-5xu1A:
undetectable
5zcqW-5xu1A:
undetectable		 5zcqN-5xu1A:
undetectable
5zcqW-5xu1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yks SNF-RELATED
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		no annotation 4 ILE A 204
LEU A 201
THR A 157
LEU A 156
 None
 0.83A 5zcqN-5yksA:
undetectable
5zcqW-5yksA:
undetectable		 5zcqN-5yksA:
19.85
5zcqW-5yksA:
9.42