SIMILAR PATTERNS OF AMINO ACIDS FOR 5ZCQ_P_CHDP306_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1914 SIGNAL RECOGNITION
PARTICLE 9/14 FUSION
PROTEIN

(Mus musculus) 		PF02290
(SRP14)
PF05486
(SRP9-21) 		4 LEU A2086
PHE A2017
LEU A2013
PHE A2009
 None
 0.92A 5zcqP-1914A:
0.8
5zcqW-1914A:
0.0		 5zcqP-1914A:
19.40
5zcqW-1914A:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1buc BUTYRYL-COA
DEHYDROGENASE

(Megasphaera
elsdenii) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ARG A  31
LEU A  41
PHE A  19
LEU A  24
 None
 0.95A 5zcqP-1bucA:
3.8
5zcqW-1bucA:
0.0		 5zcqP-1bucA:
17.69
5zcqW-1bucA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj3 ADENYLOSUCCINATE
SYNTHETASE

(Triticum
aestivum) 		PF00709
(Adenylsucc_synt) 		4 LEU A 164
PHE A 175
LEU A 179
PHE A 183
 None
 0.65A 5zcqP-1dj3A:
undetectable
5zcqW-1dj3A:
undetectable		 5zcqP-1dj3A:
19.00
5zcqW-1dj3A:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ji6 PESTICIDIAL CRYSTAL
PROTEIN CRY3BB

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 LEU A 137
GLN A 138
PHE A 141
PHE A 178
 None
 0.91A 5zcqP-1ji6A:
3.0
5zcqW-1ji6A:
0.0		 5zcqP-1ji6A:
19.52
5zcqW-1ji6A:
7.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js6 DOPA DECARBOXYLASE

(Sus scrofa) 		PF00282
(Pyridoxal_deC) 		4 LEU A 114
PHE A 357
LEU A 360
PHE A 364
 None
 0.88A 5zcqP-1js6A:
undetectable
5zcqW-1js6A:
0.0		 5zcqP-1js6A:
19.84
5zcqW-1js6A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfu M-CALPAIN LARGE
SUBUNIT

(Homo sapiens) 		PF00648
(Peptidase_C2)
PF01067
(Calpain_III)
PF13833
(EF-hand_8) 		4 LEU L  45
GLN L  47
PHE L  46
PHE L 131
 None
 0.94A 5zcqP-1kfuL:
0.0
5zcqW-1kfuL:
0.0		 5zcqP-1kfuL:
16.26
5zcqW-1kfuL:
6.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ny5 TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)

(Aquifex
aeolicus) 		PF00072
(Response_reg)
PF00158
(Sigma54_activat) 		4 LEU A 194
PHE A 204
LEU A 208
PHE A 227
 None
 0.84A 5zcqP-1ny5A:
undetectable
5zcqW-1ny5A:
0.0		 5zcqP-1ny5A:
19.75
5zcqW-1ny5A:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ovl ORPHAN NUCLEAR
RECEPTOR NURR1 (MSE
496, 511)

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU B 570
GLN B 571
PHE B 574
PHE B 592
 None
 0.69A 5zcqP-1ovlB:
0.6
5zcqW-1ovlB:
0.0		 5zcqP-1ovlB:
19.94
5zcqW-1ovlB:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgr PROTEIN (G-CSF
RECEPTOR)

(Mus musculus) 		no annotation 4 LEU B 187
GLN B 188
LEU B 176
PHE B 174
 None
 0.93A 5zcqP-1pgrB:
undetectable
5zcqW-1pgrB:
0.0		 5zcqP-1pgrB:
19.10
5zcqW-1pgrB:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 418
GLN A 420
PHE A 501
LEU A 473
 None
 0.88A 5zcqP-1snxA:
1.4
5zcqW-1snxA:
undetectable		 5zcqP-1snxA:
19.44
5zcqW-1snxA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svr SEVERIN

(Dictyostelium
discoideum) 		PF00626
(Gelsolin) 		4 GLN A 200
PHE A 201
PHE A 245
LEU A 249
 None
 0.72A 5zcqP-1svrA:
undetectable
5zcqW-1svrA:
undetectable		 5zcqP-1svrA:
17.37
5zcqW-1svrA:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u8v GAMMA-AMINOBUTYRATE
METABOLISM
DEHYDRATASE/ISOMERAS
E

(Clostridium
aminobutyricum) 		PF03241
(HpaB)
PF11794
(HpaB_N) 		4 ARG A 433
LEU A 437
LEU A 391
PHE A 422
 None
 0.93A 5zcqP-1u8vA:
3.8
5zcqW-1u8vA:
undetectable		 5zcqP-1u8vA:
19.70
5zcqW-1u8vA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v8d HYPOTHETICAL PROTEIN
(TT1679)

(Thermus
thermophilus) 		PF04260
(DUF436) 		4 LEU A  55
GLN A  56
LEU A 100
PHE A  66
 None
 0.90A 5zcqP-1v8dA:
undetectable
5zcqW-1v8dA:
undetectable		 5zcqP-1v8dA:
21.82
5zcqW-1v8dA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vku ACYL CARRIER PROTEIN

(Thermotoga
maritima) 		PF00550
(PP-binding) 		4 LEU A  70
PHE A  48
LEU A  44
PHE A  36
 None
 0.75A 5zcqP-1vkuA:
undetectable
5zcqW-1vkuA:
undetectable		 5zcqP-1vkuA:
13.64
5zcqW-1vkuA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xho CHORISMATE MUTASE

(Ruminiclostridium
thermocellum) 		PF07736
(CM_1) 		4 ARG A  62
GLN A  24
PHE A  46
LEU A  71
 None
 0.96A 5zcqP-1xhoA:
undetectable
5zcqW-1xhoA:
undetectable		 5zcqP-1xhoA:
17.72
5zcqW-1xhoA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xw8 UPF0271 PROTEIN YBGL

(Escherichia
coli) 		PF03746
(LamB_YcsF) 		4 GLN A 186
PHE A 227
LEU A 231
PHE A 235
 None
 0.86A 5zcqP-1xw8A:
undetectable
5zcqW-1xw8A:
undetectable		 5zcqP-1xw8A:
18.97
5zcqW-1xw8A:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xw8 UPF0271 PROTEIN YBGL

(Escherichia
coli) 		PF03746
(LamB_YcsF) 		4 LEU A 188
GLN A 186
PHE A 227
PHE A 235
 None
 0.90A 5zcqP-1xw8A:
undetectable
5zcqW-1xw8A:
undetectable		 5zcqP-1xw8A:
18.97
5zcqW-1xw8A:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y4u CHAPERONE PROTEIN
HTPG

(Escherichia
coli) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		4 LEU A 382
PHE A 378
PHE A 374
LEU A 360
 None
 0.93A 5zcqP-1y4uA:
undetectable
5zcqW-1y4uA:
undetectable		 5zcqP-1y4uA:
16.99
5zcqW-1y4uA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1za4 THROMBOSPONDIN 1

(Homo sapiens) 		PF02210
(Laminin_G_2) 		4 LEU A 173
PHE A  57
LEU A  89
PHE A  99
 None
 0.96A 5zcqP-1za4A:
undetectable
5zcqW-1za4A:
undetectable		 5zcqP-1za4A:
20.43
5zcqW-1za4A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zes PHOSPHATE REGULON
TRANSCRIPTIONAL
REGULATORY PROTEIN
PHOB

(Escherichia
coli) 		PF00072
(Response_reg) 		4 LEU A  42
GLN A  41
PHE A  64
LEU A  68
 None
 0.74A 5zcqP-1zesA:
undetectable
5zcqW-1zesA:
undetectable		 5zcqP-1zesA:
16.80
5zcqW-1zesA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpy FLAGELLUM-SPECIFIC
ATP SYNTHASE

(Salmonella
enterica) 		PF00006
(ATP-synt_ab) 		4 LEU A 428
PHE A 431
PHE A 391
LEU A 395
 None
 0.92A 5zcqP-2dpyA:
undetectable
5zcqW-2dpyA:
undetectable		 5zcqP-2dpyA:
20.50
5zcqW-2dpyA:
7.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2es3 THROMBOSPONDIN-1

(Homo sapiens) 		PF02210
(Laminin_G_2) 		4 LEU A 173
PHE A  57
LEU A  89
PHE A  99
 None
 0.94A 5zcqP-2es3A:
undetectable
5zcqW-2es3A:
undetectable		 5zcqP-2es3A:
19.34
5zcqW-2es3A:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gq0 CHAPERONE PROTEIN
HTPG

(Escherichia
coli) 		PF00183
(HSP90) 		4 LEU A 382
PHE A 378
PHE A 374
LEU A 360
 None
 0.94A 5zcqP-2gq0A:
undetectable
5zcqW-2gq0A:
undetectable		 5zcqP-2gq0A:
20.30
5zcqW-2gq0A:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gtr CHROMODOMAIN Y-LIKE
PROTEIN

(Homo sapiens) 		PF00378
(ECH_1) 		4 ARG A 219
LEU A 226
GLN A 228
LEU A 122
 None
 0.92A 5zcqP-2gtrA:
undetectable
5zcqW-2gtrA:
undetectable		 5zcqP-2gtrA:
20.20
5zcqW-2gtrA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iop CHAPERONE PROTEIN
HTPG

(Escherichia
coli) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		4 LEU A 382
PHE A 378
PHE A 374
LEU A 360
 None
 0.92A 5zcqP-2iopA:
undetectable
5zcqW-2iopA:
undetectable		 5zcqP-2iopA:
16.83
5zcqW-2iopA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lkl ERYTHROCYTE MEMBRANE
PROTEIN 1 (PFEMP1)

(Plasmodium
falciparum) 		PF15445
(ATS) 		4 LEU A  54
PHE A  21
LEU A  17
PHE A   9
 None
 0.81A 5zcqP-2lklA:
undetectable
5zcqW-2lklA:
undetectable		 5zcqP-2lklA:
13.41
5zcqW-2lklA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nqi CALPAIN-1 CATALYTIC
SUBUNIT

(Rattus
norvegicus) 		PF00648
(Peptidase_C2) 		4 LEU A  55
GLN A  57
PHE A  56
PHE A 141
 None
 0.93A 5zcqP-2nqiA:
undetectable
5zcqW-2nqiA:
undetectable		 5zcqP-2nqiA:
18.98
5zcqW-2nqiA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nt8 COBALAMIN
ADENOSYLTRANSFERASE

(Lactobacillus
reuteri) 		PF01923
(Cob_adeno_trans) 		4 LEU A  95
PHE A 154
LEU A 158
PHE A 162
 None
 0.85A 5zcqP-2nt8A:
2.7
5zcqW-2nt8A:
undetectable		 5zcqP-2nt8A:
21.30
5zcqW-2nt8A:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1n SKP1-LIKE PROTEIN 1A
TRANSPORT INHIBITOR
RESPONSE 1 PROTEIN

(Arabidopsis
thaliana;
Arabidopsis
thaliana) 		PF01466
(Skp1)
PF03931
(Skp1_POZ)
PF12937
(F-box-like) 		4 PHE A  99
PHE B   9
LEU B  14
PHE B  18
 None
 0.94A 5zcqP-2p1nA:
undetectable
5zcqW-2p1nA:
undetectable		 5zcqP-2p1nA:
18.58
5zcqW-2p1nA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p25 GLYOXALASE FAMILY
PROTEIN

(Enterococcus
faecalis) 		PF00903
(Glyoxalase) 		4 LEU A 124
PHE A 114
LEU A  91
PHE A  90
 None
 0.80A 5zcqP-2p25A:
undetectable
5zcqW-2p25A:
undetectable		 5zcqP-2p25A:
17.87
5zcqW-2p25A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6z UROPORPHYRINOGEN
DECARBOXYLASE

(Homo sapiens) 		PF01208
(URO-D) 		4 LEU A 216
GLN A 215
PHE A 154
LEU A 199
 None
 0.92A 5zcqP-2q6zA:
undetectable
5zcqW-2q6zA:
undetectable		 5zcqP-2q6zA:
20.71
5zcqW-2q6zA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2riu 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE

(Candida
albicans) 		PF00926
(DHBP_synthase) 		4 LEU A 113
PHE A  93
PHE A 123
LEU A  70
 None
 0.91A 5zcqP-2riuA:
undetectable
5zcqW-2riuA:
undetectable		 5zcqP-2riuA:
21.66
5zcqW-2riuA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wp0 HOBA
CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA

(Helicobacter
pylori;
Helicobacter
pylori) 		PF12163
(HobA)
no annotation 		4 LEU A  45
GLN C  52
LEU A 170
PHE A 171
 None
 0.81A 5zcqP-2wp0A:
undetectable
5zcqW-2wp0A:
undetectable		 5zcqP-2wp0A:
20.15
5zcqW-2wp0A:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2s RPOE, ECF SIGE

(Rhodobacter
sphaeroides) 		PF04542
(Sigma70_r2)
PF04545
(Sigma70_r4) 		4 ARG A  73
LEU A 176
GLN A 178
LEU A 103
 None
 0.86A 5zcqP-2z2sA:
undetectable
5zcqW-2z2sA:
undetectable		 5zcqP-2z2sA:
18.66
5zcqW-2z2sA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zou SPONDIN-1

(Homo sapiens) 		PF02014
(Reeler) 		5 LEU A 177
GLN A 172
PHE A 171
LEU A  82
PHE A  90
 EDO  A   6 (-3.8A)
EDO  A   6 (-4.9A)
None
None
None
 1.36A 5zcqP-2zouA:
undetectable
5zcqW-2zouA:
undetectable		 5zcqP-2zouA:
15.85
5zcqW-2zouA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxx DNA REPLICATION
FACTOR CDT1

(Mus musculus) 		PF08839
(CDT1) 		4 LEU C 199
GLN C 191
LEU C 314
PHE C 310
 None
 0.89A 5zcqP-2zxxC:
undetectable
5zcqW-2zxxC:
undetectable		 5zcqP-2zxxC:
20.21
5zcqW-2zxxC:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3i PENICILLIN-BINDING
PROTEIN 4

(Haemophilus
influenzae) 		PF02113
(Peptidase_S13) 		4 GLN A 235
PHE A 251
LEU A 249
PHE A 247
 None
 0.76A 5zcqP-3a3iA:
undetectable
5zcqW-3a3iA:
undetectable		 5zcqP-3a3iA:
20.00
5zcqW-3a3iA:
8.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ba3 PYRIDOXAMINE
5'-PHOSPHATE
OXIDASE-LIKE PROTEIN

(Lactobacillus
plantarum) 		no annotation 5 LEU A 123
GLN A  87
PHE A 121
PHE A  45
LEU A  18
 None
 0.86A 5zcqP-3ba3A:
undetectable
5zcqW-3ba3A:
undetectable		 5zcqP-3ba3A:
21.19
5zcqW-3ba3A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF06421
(LepA_C) 		4 LEU C  73
PHE C  75
PHE C   7
LEU C 176
 None
 0.94A 5zcqP-3degC:
undetectable
5zcqW-3degC:
undetectable		 5zcqP-3degC:
17.43
5zcqW-3degC:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evz METHYLTRANSFERASE

(Pyrococcus
furiosus) 		PF05175
(MTS) 		4 LEU A 202
PHE A 153
LEU A 186
PHE A 182
 None
 0.97A 5zcqP-3evzA:
undetectable
5zcqW-3evzA:
undetectable		 5zcqP-3evzA:
19.78
5zcqW-3evzA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1z PUTATIVE LYSYL-TRNA
SYNTHETASE

(Salmonella
enterica) 		PF00152
(tRNA-synt_2) 		4 ARG A 188
LEU A 192
PHE A 196
PHE A 153
 None
 0.86A 5zcqP-3g1zA:
undetectable
5zcqW-3g1zA:
undetectable		 5zcqP-3g1zA:
20.94
5zcqW-3g1zA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO

(Thermus
thermophilus) 		PF01134
(GIDA) 		4 LEU A 289
GLN A 291
PHE A 199
LEU A 203
 None
 0.85A 5zcqP-3g5sA:
undetectable
5zcqW-3g5sA:
undetectable		 5zcqP-3g5sA:
20.48
5zcqW-3g5sA:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gaj COBALAMIN
ADENOSYLTRANSFERASE
PDUO-LIKE PROTEIN

(Lactobacillus
reuteri) 		PF01923
(Cob_adeno_trans) 		4 LEU A  95
PHE A 154
LEU A 158
PHE A 162
 None
 0.84A 5zcqP-3gajA:
2.7
5zcqW-3gajA:
undetectable		 5zcqP-3gajA:
21.16
5zcqW-3gajA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4l DNA MISMATCH REPAIR
PROTEIN PMS1

(Saccharomyces
cerevisiae) 		PF01119
(DNA_mis_repair)
PF13589
(HATPase_c_3) 		4 LEU A 181
GLN A 180
PHE A 192
LEU A  55
 None
 0.80A 5zcqP-3h4lA:
undetectable
5zcqW-3h4lA:
undetectable		 5zcqP-3h4lA:
19.18
5zcqW-3h4lA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		4 LEU A 196
GLN A 193
PHE A 200
LEU A 162
 None
 0.91A 5zcqP-3hjrA:
undetectable
5zcqW-3hjrA:
undetectable		 5zcqP-3hjrA:
17.67
5zcqW-3hjrA:
6.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3t UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 21

(Homo sapiens) 		PF00443
(UCH) 		4 LEU A 378
GLN A 453
PHE A 397
LEU A 400
 None
 0.93A 5zcqP-3i3tA:
undetectable
5zcqW-3i3tA:
undetectable		 5zcqP-3i3tA:
21.07
5zcqW-3i3tA:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iv0 SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 LEU A 230
PHE A 151
LEU A 155
PHE A 159
 None
 0.78A 5zcqP-3iv0A:
1.9
5zcqW-3iv0A:
undetectable		 5zcqP-3iv0A:
20.57
5zcqW-3iv0A:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9d OUTER CAPSID PROTEIN
VP2

(Bluetongue
virus) 		PF00898
(Orbi_VP2) 		4 LEU A 530
PHE A 569
LEU A 566
PHE A 526
 None
 0.95A 5zcqP-3j9dA:
undetectable
5zcqW-3j9dA:
undetectable		 5zcqP-3j9dA:
13.31
5zcqW-3j9dA:
5.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nbu GLUCOSE-6-PHOSPHATE
ISOMERASE

(Escherichia
coli) 		PF00342
(PGI) 		4 LEU A  15
GLN A  16
PHE A  19
LEU A  66
 None
 0.83A 5zcqP-3nbuA:
undetectable
5zcqW-3nbuA:
undetectable		 5zcqP-3nbuA:
18.63
5zcqW-3nbuA:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nhe UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2

(Homo sapiens) 		PF00443
(UCH) 		4 LEU A 419
GLN A 492
PHE A 438
LEU A 441
 None
 0.92A 5zcqP-3nheA:
undetectable
5zcqW-3nheA:
undetectable		 5zcqP-3nheA:
20.23
5zcqW-3nheA:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ob4 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ARAH 2

(Escherichia
coli;
Arachis
duranensis) 		PF00234
(Tryp_alpha_amyl)
PF13416
(SBP_bac_8) 		4 LEU A1046
GLN A1048
PHE A1126
LEU A1130
 None
 0.85A 5zcqP-3ob4A:
undetectable
5zcqW-3ob4A:
undetectable		 5zcqP-3ob4A:
15.02
5zcqW-3ob4A:
7.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oox PUTATIVE 2OG-FE(II)
OXYGENASE FAMILY
PROTEIN

(Caulobacter
vibrioides) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		4 PHE A  11
PHE A  21
LEU A  25
PHE A  29
 EDO  A 320 (-4.5A)
None
None
None
 0.95A 5zcqP-3ooxA:
undetectable
5zcqW-3ooxA:
undetectable		 5zcqP-3ooxA:
19.64
5zcqW-3ooxA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqq PUTATIVE LIPOPROTEIN

(Bacteroides
ovatus) 		PF16129
(DUF4841)
PF16130
(DUF4842) 		4 LEU A 214
PHE A 152
PHE A 173
LEU A 201
 None
 0.97A 5zcqP-3oqqA:
undetectable
5zcqW-3oqqA:
undetectable		 5zcqP-3oqqA:
20.13
5zcqW-3oqqA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4i PHOSPHOHYDROLASE
(MUTT/NUDIX FAMILY
PROTEIN)

(Bacillus cereus) 		PF00293
(NUDIX)
PF12535
(Nudix_N) 		4 LEU A  81
PHE A  83
LEU A  94
PHE A 148
 None
 0.73A 5zcqP-3q4iA:
3.5
5zcqW-3q4iA:
undetectable		 5zcqP-3q4iA:
20.44
5zcqW-3q4iA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qde CELLOBIOSE
PHOSPHORYLASE

(Ruminiclostridium
thermocellum) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 LEU A 134
GLN A 255
LEU A 146
PHE A  72
 None
 0.88A 5zcqP-3qdeA:
undetectable
5zcqW-3qdeA:
undetectable		 5zcqP-3qdeA:
15.31
5zcqW-3qdeA:
4.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qdn PUTATIVE THIOREDOXIN
PROTEIN

(Salmonella
enterica) 		PF00085
(Thioredoxin)
PF14559
(TPR_19)
PF14561
(TPR_20) 		4 LEU A 236
PHE A 240
PHE A 258
LEU A 262
 None
 0.59A 5zcqP-3qdnA:
undetectable
5zcqW-3qdnA:
undetectable		 5zcqP-3qdnA:
21.02
5zcqW-3qdnA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqz PUTATIVE
UNCHARACTERIZED
PROTEIN YJIK

(Escherichia
coli) 		PF06977
(SdiA-regulated) 		4 LEU A 234
GLN A 235
PHE A 238
LEU A 255
 None
 0.95A 5zcqP-3qqzA:
undetectable
5zcqW-3qqzA:
undetectable		 5zcqP-3qqzA:
22.58
5zcqW-3qqzA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b4d FERREDOXIN-NADP
REDUCTASE

(Xanthomonas
citri) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 LEU A 100
GLN A  37
PHE A  38
PHE A 252
 None
None
FAD  A1260 ( 3.6A)
None
 0.95A 5zcqP-4b4dA:
undetectable
5zcqW-4b4dA:
undetectable		 5zcqP-4b4dA:
20.59
5zcqW-4b4dA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF04054
(Not1) 		4 LEU A1975
GLN A1976
LEU A2026
PHE A2034
 None
 0.94A 5zcqP-4c0dA:
2.6
5zcqW-4c0dA:
undetectable		 5zcqP-4c0dA:
14.62
5zcqW-4c0dA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d0o A-KINASE ANCHOR
PROTEIN 13

(Homo sapiens) 		PF00621
(RhoGEF) 		4 GLN A2008
PHE A2011
PHE A2057
LEU A2061
 None
 0.51A 5zcqP-4d0oA:
3.5
5zcqW-4d0oA:
undetectable		 5zcqP-4d0oA:
17.79
5zcqW-4d0oA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dpz HRAS-LIKE SUPPRESSOR
2

(Homo sapiens) 		PF04970
(LRAT) 		4 ARG X2095
GLN X2102
PHE X2116
LEU X2120
 None
 0.91A 5zcqP-4dpzX:
undetectable
5zcqW-4dpzX:
undetectable		 5zcqP-4dpzX:
18.93
5zcqW-4dpzX:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e5t MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME, C-TERMINAL
DOMAIN PROTEIN

(Labrenzia
alexandrii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 321
PHE A  23
PHE A  25
LEU A 376
 None
 0.93A 5zcqP-4e5tA:
undetectable
5zcqW-4e5tA:
undetectable		 5zcqP-4e5tA:
21.58
5zcqW-4e5tA:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4em8 RIBOSE 5-PHOSPHATE
ISOMERASE B

(Anaplasma
phagocytophilum) 		PF02502
(LacAB_rpiB) 		4 LEU A 121
GLN A 118
PHE A 107
LEU A 105
 None
 0.97A 5zcqP-4em8A:
undetectable
5zcqW-4em8A:
undetectable		 5zcqP-4em8A:
18.77
5zcqW-4em8A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4flx DNA POLYMERASE 1

(Pyrococcus
abyssi) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 ARG A 266
LEU A 352
PHE A 356
LEU A 333
 ARG  A 266 ( 0.6A)
LEU  A 352 ( 0.6A)
PHE  A 356 ( 1.3A)
LEU  A 333 ( 0.6A)
 0.93A 5zcqP-4flxA:
2.6
5zcqW-4flxA:
undetectable		 5zcqP-4flxA:
13.49
5zcqW-4flxA:
6.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i2w PROTEIN UNC-45

(Caenorhabditis
elegans) 		PF11701
(UNC45-central) 		4 LEU A 373
GLN A 374
LEU A 347
PHE A 420
 None
 0.90A 5zcqP-4i2wA:
2.3
5zcqW-4i2wA:
undetectable		 5zcqP-4i2wA:
14.04
5zcqW-4i2wA:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l4u TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)

(Aquifex
aeolicus) 		PF00072
(Response_reg)
PF00158
(Sigma54_activat) 		4 LEU A 194
PHE A 204
LEU A 208
PHE A 227
 None
 0.83A 5zcqP-4l4uA:
undetectable
5zcqW-4l4uA:
undetectable		 5zcqP-4l4uA:
18.32
5zcqW-4l4uA:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5p UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF09994
(DUF2235) 		4 LEU A 148
GLN A 150
PHE A 244
LEU A 248
 None
 0.96A 5zcqP-4o5pA:
undetectable
5zcqW-4o5pA:
undetectable		 5zcqP-4o5pA:
13.14
5zcqW-4o5pA:
5.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oca UDP-4-AMINO-4-DEOXY-
L-ARABINOSE--OXOGLUT
ARATE
AMINOTRANSFERASE

(Salmonella
enterica) 		PF01041
(DegT_DnrJ_EryC1) 		4 LEU A 256
GLN A 255
PHE A  48
LEU A  51
 None
 0.97A 5zcqP-4ocaA:
undetectable
5zcqW-4ocaA:
undetectable		 5zcqP-4ocaA:
21.12
5zcqW-4ocaA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnc ESTERASE

(Rhodococcus sp.
ECU1013) 		PF12697
(Abhydrolase_6) 		4 ARG A 196
LEU A 163
PHE A 185
LEU A 189
 None
 0.80A 5zcqP-4rncA:
undetectable
5zcqW-4rncA:
undetectable		 5zcqP-4rncA:
21.32
5zcqW-4rncA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wlp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE ISOZYME L5
NUCLEAR FACTOR
RELATED TO
KAPPA-B-BINDING
PROTEIN

(Homo sapiens;
Homo sapiens) 		PF01088
(Peptidase_C12)
no annotation 		4 LEU B  70
GLN B  71
PHE A 294
LEU A 298
 None
 0.74A 5zcqP-4wlpB:
undetectable
5zcqW-4wlpB:
undetectable		 5zcqP-4wlpB:
17.50
5zcqW-4wlpB:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgt FRQ-INTERACTING RNA
HELICASE

(Neurospora
crassa) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		4 LEU A 524
GLN A 526
PHE A 525
LEU A 502
 None
 0.88A 5zcqP-4xgtA:
undetectable
5zcqW-4xgtA:
undetectable		 5zcqP-4xgtA:
12.69
5zcqW-4xgtA:
6.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7d INSCUTEABLE

(Drosophila
melanogaster) 		no annotation 4 LEU L 356
GLN L 357
PHE L 399
LEU L 403
 None
 0.65A 5zcqP-5a7dL:
6.6
5zcqW-5a7dL:
undetectable		 5zcqP-5a7dL:
19.25
5zcqW-5a7dL:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a98 POLYHEDRIN

(Cypovirus 15) 		no annotation 4 LEU A 111
GLN A 110
LEU A 187
PHE A 189
 None
 0.96A 5zcqP-5a98A:
undetectable
5zcqW-5a98A:
undetectable		 5zcqP-5a98A:
21.31
5zcqW-5a98A:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ady GTPASE HFLX

(Escherichia
coli) 		PF01926
(MMR_HSR1)
PF13167
(GTP-bdg_N)
PF16360
(GTP-bdg_M) 		4 LEU 6 402
GLN 6 403
PHE 6 383
LEU 6 379
 None
 0.75A 5zcqP-5ady6:
3.1
5zcqW-5ady6:
undetectable		 5zcqP-5ady6:
18.29
5zcqW-5ady6:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5amq RNA POLYMERASE L

(California
encephalitis
orthobunyavirus) 		PF04196
(Bunya_RdRp)
PF15518
(L_protein_N) 		4 LEU A 747
GLN A 744
PHE A 751
LEU A1257
 None
 0.95A 5zcqP-5amqA:
undetectable
5zcqW-5amqA:
undetectable		 5zcqP-5amqA:
7.40
5zcqW-5amqA:
2.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aox SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN

(Homo sapiens) 		PF02290
(SRP14) 		4 LEU B  86
PHE B  17
LEU B  13
PHE B   9
 None
 0.86A 5zcqP-5aoxB:
undetectable
5zcqW-5aoxB:
undetectable		 5zcqP-5aoxB:
17.86
5zcqW-5aoxB:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bza BETA-N-ACETYLHEXOSAM
INIDASE

(Thermotoga
neapolitana) 		PF00933
(Glyco_hydro_3) 		5 LEU A 463
GLN A 460
PHE A 459
PHE A 378
LEU A 343
 None
 1.00A 5zcqP-5bzaA:
undetectable
5zcqW-5bzaA:
undetectable		 5zcqP-5bzaA:
17.12
5zcqW-5bzaA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c9d APRICK PROTEASE

(Rickettsia
conorii) 		PF13975
(gag-asp_proteas) 		4 LEU A 156
GLN A 154
PHE A 158
LEU A 183
 None
 0.93A 5zcqP-5c9dA:
undetectable
5zcqW-5c9dA:
undetectable		 5zcqP-5c9dA:
17.54
5zcqW-5c9dA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ckm MANNAN-BINDING
LECTIN SERINE
PEPTIDASE 2

(Rattus
norvegicus) 		PF00431
(CUB)
PF07645
(EGF_CA) 		4 ARG A  80
LEU A  70
PHE A 111
PHE A  42
 None
 0.94A 5zcqP-5ckmA:
undetectable
5zcqW-5ckmA:
undetectable		 5zcqP-5ckmA:
22.33
5zcqW-5ckmA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5du9 CDA PEPTIDE
SYNTHETASE I

(Streptomyces
coelicolor) 		PF00668
(Condensation) 		4 LEU A 423
GLN A 424
PHE A 427
LEU A 229
 None
 0.78A 5zcqP-5du9A:
undetectable
5zcqW-5du9A:
undetectable		 5zcqP-5du9A:
20.97
5zcqW-5du9A:
7.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e0c CELLULASE

(Bacillus sp.
BG-CS10) 		PF00150
(Cellulase)
PF03442
(CBM_X2) 		4 LEU A 429
GLN A 428
PHE A 427
LEU A 400
 None
 0.95A 5zcqP-5e0cA:
undetectable
5zcqW-5e0cA:
undetectable		 5zcqP-5e0cA:
20.19
5zcqW-5e0cA:
8.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e5u RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE GAMMA

(Mus musculus) 		PF00194
(Carb_anhydrase) 		4 LEU A 246
PHE A 270
LEU A 242
PHE A 107
 None
 0.90A 5zcqP-5e5uA:
undetectable
5zcqW-5e5uA:
undetectable		 5zcqP-5e5uA:
19.59
5zcqW-5e5uA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9c HEPARANASE

(Homo sapiens) 		PF03662
(Glyco_hydro_79n) 		4 LEU A 495
GLN A 494
LEU A 409
PHE A 531
 None
 0.96A 5zcqP-5e9cA:
undetectable
5zcqW-5e9cA:
undetectable		 5zcqP-5e9cA:
21.23
5zcqW-5e9cA:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fn3 PRESENILIN-1

(Homo sapiens) 		PF01080
(Presenilin) 		4 LEU B 392
PHE B 388
LEU B 443
PHE B 447
 None
 0.92A 5zcqP-5fn3B:
2.1
5zcqW-5fn3B:
undetectable		 5zcqP-5fn3B:
20.04
5zcqW-5fn3B:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hvm ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)

(Aspergillus
fumigatus) 		PF00982
(Glyco_transf_20) 		4 PHE A 182
PHE A 109
LEU A 105
PHE A 100
 None
 0.90A 5zcqP-5hvmA:
undetectable
5zcqW-5hvmA:
undetectable		 5zcqP-5hvmA:
18.38
5zcqW-5hvmA:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ipx ORF49 PROTEIN

(Human
gammaherpesvirus
8) 		PF04793
(Herpes_BBRF1) 		4 LEU A  87
PHE A 204
LEU A 208
PHE A 212
 None
 0.78A 5zcqP-5ipxA:
undetectable
5zcqW-5ipxA:
undetectable		 5zcqP-5ipxA:
20.47
5zcqW-5ipxA:
11.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5iy5 CYTOCHROME C OXIDASE
SUBUNIT 3

(Bos taurus) 		PF00510
(COX3) 		5 ARG C 156
LEU C 160
PHE C 164
PHE C 219
LEU C 223
 CHD  C 307 (-4.0A)
CHD  C 307 ( 3.9A)
CHD  C 307 (-3.9A)
None
None
 0.16A 5zcqP-5iy5C:
37.4
5zcqW-5iy5C:
undetectable		 5zcqP-5iy5C:
100.00
5zcqW-5iy5C:
10.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5iy5 CYTOCHROME C OXIDASE
SUBUNIT 3

(Bos taurus) 		PF00510
(COX3) 		5 LEU C 160
GLN C 161
PHE C 164
PHE C 219
LEU C 223
 CHD  C 307 ( 3.9A)
CHD  C 307 (-4.3A)
CHD  C 307 (-3.9A)
None
None
 0.60A 5zcqP-5iy5C:
37.4
5zcqW-5iy5C:
undetectable		 5zcqP-5iy5C:
100.00
5zcqW-5iy5C:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbg LGP2

(Gallus gallus) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD) 		4 LEU A 335
GLN A 336
PHE A 229
LEU A 233
 None
 0.52A 5zcqP-5jbgA:
3.1
5zcqW-5jbgA:
undetectable		 5zcqP-5jbgA:
15.81
5zcqW-5jbgA:
6.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jcv LMO2181 PROTEIN

(Listeria
monocytogenes) 		PF04203
(Sortase) 		4 LEU A 223
GLN A 240
PHE A 159
LEU A  78
 None
 0.94A 5zcqP-5jcvA:
undetectable
5zcqW-5jcvA:
undetectable		 5zcqP-5jcvA:
18.77
5zcqW-5jcvA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjh 4-ALPHA-GLUCANOTRANS
FERASE

(Corynebacterium
glutamicum) 		PF02446
(Glyco_hydro_77) 		4 LEU A 297
GLN A 295
PHE A 355
LEU A 359
 None
 0.95A 5zcqP-5jjhA:
undetectable
5zcqW-5jjhA:
undetectable		 5zcqP-5jjhA:
18.24
5zcqW-5jjhA:
5.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ju6 BETA-GLUCOSIDASE

(Rasamsonia
emersonii) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 ARG A  82
LEU A  83
PHE A  50
LEU A  54
 None
 0.88A 5zcqP-5ju6A:
undetectable
5zcqW-5ju6A:
undetectable		 5zcqP-5ju6A:
13.89
5zcqW-5ju6A:
5.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lsk PROTEIN MIS12
HOMOLOG
POLYAMINE-MODULATED
FACTOR 1

(Homo sapiens;
Homo sapiens) 		PF05859
(Mis12)
PF03980
(Nnf1) 		4 LEU A  78
PHE A  79
PHE B  45
LEU B  49
 None
 0.88A 5zcqP-5lskA:
undetectable
5zcqW-5lskA:
undetectable		 5zcqP-5lskA:
21.82
5zcqW-5lskA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nbs BETA-GLUCOSIDASE

(Neurospora
crassa) 		no annotation 4 ARG A  78
LEU A  79
PHE A  46
LEU A  50
 None
 0.95A 5zcqP-5nbsA:
undetectable
5zcqW-5nbsA:
undetectable		 5zcqP-5nbsA:
undetectable
5zcqW-5nbsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oen INTERFERON
REGULATORY FACTOR 9

(Mus musculus) 		no annotation 4 PHE A 339
PHE A 322
LEU A 326
PHE A 330
 None
 0.81A 5zcqP-5oenA:
undetectable
5zcqW-5oenA:
undetectable		 5zcqP-5oenA:
undetectable
5zcqW-5oenA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uvn PARAQUAT-INDUCIBLE
PROTEIN B

(Escherichia
coli) 		PF02470
(MlaD) 		4 LEU A 202
GLN A 201
PHE A 203
PHE A 250
 None
 0.94A 5zcqP-5uvnA:
undetectable
5zcqW-5uvnA:
undetectable		 5zcqP-5uvnA:
20.54
5zcqW-5uvnA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjj MULTI DRUG EFFLUX
TRANSPORTER

(Camelina sativa) 		PF01554
(MatE) 		4 LEU A 348
PHE A 344
PHE A 380
LEU A 376
 None
 0.81A 5zcqP-5xjjA:
3.3
5zcqW-5xjjA:
undetectable		 5zcqP-5xjjA:
22.22
5zcqW-5xjjA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT

(Komagataella
phaffii) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 LEU A 868
GLN A 866
PHE A 867
LEU A1002
 None
 0.96A 5zcqP-5xogA:
3.9
5zcqW-5xogA:
undetectable		 5zcqP-5xogA:
9.55
5zcqW-5xogA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c26 DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT 1
DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT OST5

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		no annotation
no annotation 		4 LEU 5  73
PHE 5  28
PHE 5  77
PHE 1 447
 None
 0.84A 5zcqP-6c265:
3.2
5zcqW-6c265:
undetectable		 5zcqP-6c265:
undetectable
5zcqW-6c265:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c29 PUTATIVE METAL
RESISTANCE PROTEIN

(Proteus
mirabilis) 		no annotation 4 LEU A 167
GLN A 166
LEU A 227
PHE A 229
 None
 0.84A 5zcqP-6c29A:
undetectable
5zcqW-6c29A:
undetectable		 5zcqP-6c29A:
undetectable
5zcqW-6c29A:
undetectable