SIMILAR PATTERNS OF AMINO ACIDS FOR 5ZCQ_J_CHDJ101_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flo FLP RECOMBINASE

(Saccharomyces
cerevisiae) 		PF03930
(Flp_N)
PF05202
(Flp_C) 		4 ILE A 350
MET A 311
THR A 312
LEU A 315
 None
 0.77A 5zcqA-1floA:
0.1
5zcqJ-1floA:
0.0		 5zcqA-1floA:
21.78
5zcqJ-1floA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus 1) 		PF00078
(RVT_1) 		4 LEU A 109
MET A 164
THR A 165
LEU A 168
 None
 0.70A 5zcqA-1harA:
undetectable
5zcqJ-1harA:
0.1		 5zcqA-1harA:
18.00
5zcqJ-1harA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1idj PECTIN LYASE A

(Aspergillus
niger) 		PF00544
(Pec_lyase_C) 		4 ILE A 337
LEU A 306
ARG A 188
LEU A 245
 None
 0.95A 5zcqA-1idjA:
undetectable
5zcqJ-1idjA:
0.0		 5zcqA-1idjA:
21.59
5zcqJ-1idjA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE

(Sulfolobus
acidocaldarius) 		PF00128
(Alpha-amylase)
PF09196
(DUF1953) 		4 ILE A 129
LEU A 181
TYR A 190
LEU A 104
 None
None
None
MLZ  A 105 ( 4.3A)
 0.92A 5zcqA-1iv8A:
0.0
5zcqJ-1iv8A:
undetectable		 5zcqA-1iv8A:
20.68
5zcqJ-1iv8A:
5.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iyr DNA FRAGMENTATION
FACTOR ALPHA SUBUNIT

(Homo sapiens) 		PF09033
(DFF-C) 		4 ILE A  21
LEU A  22
ARG A   9
THR A   5
 None
 0.95A 5zcqA-1iyrA:
undetectable
5zcqJ-1iyrA:
0.0		 5zcqA-1iyrA:
10.96
5zcqJ-1iyrA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jed SULFATE
ADENYLYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 ILE A  48
LEU A  49
THR A  38
LEU A  37
 None
 0.77A 5zcqA-1jedA:
0.0
5zcqJ-1jedA:
undetectable		 5zcqA-1jedA:
21.17
5zcqJ-1jedA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jfi TRANSCRIPTION
REGULATOR NC2 ALPHA
CHAIN
TRANSCRIPTION
REGULATOR NC2 BETA
CHAIN

(Homo sapiens;
Homo sapiens) 		PF00808
(CBFD_NFYB_HMF)
PF00808
(CBFD_NFYB_HMF) 		4 ILE B 122
LEU B 126
THR A  67
LEU A  70
 None
 0.97A 5zcqA-1jfiB:
undetectable
5zcqJ-1jfiB:
1.6		 5zcqA-1jfiB:
14.49
5zcqJ-1jfiB:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k7s FERRICHROME-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli) 		PF01497
(Peripla_BP_2) 		4 ILE N 292
LEU N 288
THR N 180
LEU N 179
 None
 0.89A 5zcqA-1k7sN:
undetectable
5zcqJ-1k7sN:
0.0		 5zcqA-1k7sN:
20.17
5zcqJ-1k7sN:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1khc DNA CYTOSINE-5
METHYLTRANSFERASE
3B2

(Mus musculus) 		PF00855
(PWWP) 		4 TYR A 305
ARG A 306
MET A 309
LEU A 313
 None
 0.96A 5zcqA-1khcA:
undetectable
5zcqJ-1khcA:
undetectable		 5zcqA-1khcA:
13.81
5zcqJ-1khcA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01063
(Aminotran_4) 		4 ILE A 332
MET A 293
THR A 292
LEU A 235
 None
 0.86A 5zcqA-1kt8A:
0.0
5zcqJ-1kt8A:
undetectable		 5zcqA-1kt8A:
22.71
5zcqJ-1kt8A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lc7 L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE

(Salmonella
enterica) 		PF00155
(Aminotran_1_2) 		4 LEU A 182
ARG A 100
THR A 144
LEU A 143
 None
 0.87A 5zcqA-1lc7A:
0.0
5zcqJ-1lc7A:
undetectable		 5zcqA-1lc7A:
21.47
5zcqJ-1lc7A:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mc8 FLAP ENDONUCLEASE-1

(Pyrococcus
horikoshii) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		4 ILE A   5
LEU A   8
ARG A 223
THR A 222
 None
 0.84A 5zcqA-1mc8A:
0.0
5zcqJ-1mc8A:
undetectable		 5zcqA-1mc8A:
20.59
5zcqJ-1mc8A:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ml4 ASPARTATE
TRANSCARBAMOYLASE

(Pyrococcus
abyssi) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 ILE A 104
LEU A  50
ARG A 115
LEU A  90
 None
 0.87A 5zcqA-1ml4A:
0.0
5zcqJ-1ml4A:
undetectable		 5zcqA-1ml4A:
21.77
5zcqJ-1ml4A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ozn RETICULON 4 RECEPTOR

(Homo sapiens) 		PF13855
(LRR_8) 		4 LEU A 112
ARG A  61
THR A  84
LEU A 107
 None
 0.84A 5zcqA-1oznA:
undetectable
5zcqJ-1oznA:
undetectable		 5zcqA-1oznA:
19.64
5zcqJ-1oznA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9d UV EXCISION REPAIR
PROTEIN RAD23
HOMOLOG A

(Homo sapiens) 		PF00240
(ubiquitin) 		4 ILE U   5
LEU U  28
ARG U  65
LEU U  55
 None
 0.96A 5zcqA-1p9dU:
undetectable
5zcqJ-1p9dU:
undetectable		 5zcqA-1p9dU:
8.56
5zcqJ-1p9dU:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pm2 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 1
BETA CHAIN

(Escherichia
coli) 		PF00268
(Ribonuc_red_sm) 		5 ILE A 335
LEU A 339
TYR A 310
ARG A 328
THR A 312
 None
None
None
HG  A 614 ( 4.9A)
None
 1.45A 5zcqA-1pm2A:
1.0
5zcqJ-1pm2A:
undetectable		 5zcqA-1pm2A:
19.19
5zcqJ-1pm2A:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qf7 PROTEIN (CATALASE
HPII)

(Escherichia
coli) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 ILE A 666
MET A 736
THR A 734
LEU A 733
 None
 0.92A 5zcqA-1qf7A:
0.0
5zcqJ-1qf7A:
undetectable		 5zcqA-1qf7A:
21.37
5zcqJ-1qf7A:
6.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qst TGCN5 HISTONE ACETYL
TRANSFERASE

(Tetrahymena
thermophila) 		PF00583
(Acetyltransf_1) 		4 ILE A  72
LEU A  69
ARG A 135
LEU A 141
 None
 0.92A 5zcqA-1qstA:
undetectable
5zcqJ-1qstA:
undetectable		 5zcqA-1qstA:
13.35
5zcqJ-1qstA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6x ATP:SULFATE
ADENYLYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 ILE A  48
LEU A  49
THR A  38
LEU A  37
 None
 0.74A 5zcqA-1r6xA:
undetectable
5zcqJ-1r6xA:
undetectable		 5zcqA-1r6xA:
21.48
5zcqJ-1r6xA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u00 CHAPERONE PROTEIN
HSCA

(Escherichia
coli) 		PF00012
(HSP70) 		4 ILE A 409
LEU A 396
ARG A 470
THR A 484
 None
 0.77A 5zcqA-1u00A:
2.4
5zcqJ-1u00A:
undetectable		 5zcqA-1u00A:
17.75
5zcqJ-1u00A:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ua4 ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
furiosus) 		PF04587
(ADP_PFK_GK) 		4 ILE A  48
LEU A  74
ARG A 186
LEU A  39
 None
 0.95A 5zcqA-1ua4A:
undetectable
5zcqJ-1ua4A:
undetectable		 5zcqA-1ua4A:
20.36
5zcqJ-1ua4A:
8.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9v KIAA0561 PROTEIN

(Homo sapiens) 		PF08926
(DUF1908) 		4 ILE A 102
LEU A  99
THR A  23
LEU A  22
 None
 0.95A 5zcqA-1v9vA:
2.3
5zcqJ-1v9vA:
undetectable		 5zcqA-1v9vA:
12.30
5zcqJ-1v9vA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ysp TRANSCRIPTIONAL
REGULATOR KDGR

(Escherichia
coli) 		PF01614
(IclR) 		4 ILE A  35
LEU A  24
ARG A  53
LEU A  65
 None
 0.87A 5zcqA-1yspA:
undetectable
5zcqJ-1yspA:
undetectable		 5zcqA-1yspA:
15.37
5zcqJ-1yspA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli) 		PF04952
(AstE_AspA) 		4 ILE A  48
LEU A 144
THR A 148
LEU A 211
 None
 0.98A 5zcqA-1yw6A:
undetectable
5zcqJ-1yw6A:
undetectable		 5zcqA-1yw6A:
20.62
5zcqJ-1yw6A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yx1 HYPOTHETICAL PROTEIN
PA2260

(Pseudomonas
aeruginosa) 		PF01261
(AP_endonuc_2) 		4 LEU A  10
ARG A  90
THR A  51
LEU A  54
 None
 0.94A 5zcqA-1yx1A:
undetectable
5zcqJ-1yx1A:
undetectable		 5zcqA-1yx1A:
18.52
5zcqJ-1yx1A:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zv4 REGULATOR OF
G-PROTEIN SIGNALING
17

(Homo sapiens) 		PF00615
(RGS) 		4 ILE X 178
LEU X 181
ARG X  95
LEU X 102
 None
 0.95A 5zcqA-1zv4X:
undetectable
5zcqJ-1zv4X:
undetectable		 5zcqA-1zv4X:
13.67
5zcqJ-1zv4X:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9b FUSION GLYCOPROTEIN
F0

(Mammalian
rubulavirus 5) 		PF00523
(Fusion_gly) 		4 LEU A 227
TYR A  72
THR A  77
LEU A  80
 None
 0.73A 5zcqA-2b9bA:
undetectable
5zcqJ-2b9bA:
2.5		 5zcqA-2b9bA:
21.63
5zcqJ-2b9bA:
9.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2be7 ASPARTATE
CARBAMOYLTRANSFERASE
CATALYTIC CHAIN
ASPARTATE
CARBAMOYLTRANSFERASE
REGULATORY CHAIN

(Moritella
profunda;
Moritella
profunda) 		PF00185
(OTCace)
PF02729
(OTCace_N)
PF01948
(PyrI)
PF02748
(PyrI_C) 		4 ILE D 114
LEU A 115
ARG A 106
MET A 105
 None
 0.83A 5zcqA-2be7D:
undetectable
5zcqJ-2be7D:
undetectable		 5zcqA-2be7D:
17.43
5zcqJ-2be7D:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buc DIPEPTIDYL PEPTIDASE
IV

(Sus scrofa) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 ILE A 384
ARG A 433
THR A 411
LEU A 410
 None
 0.97A 5zcqA-2bucA:
undetectable
5zcqJ-2bucA:
undetectable		 5zcqA-2bucA:
19.97
5zcqJ-2bucA:
7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bwg GMP REDUCTASE I

(Homo sapiens) 		PF00478
(IMPDH) 		4 ILE A 154
MET A 113
THR A 114
LEU A 117
 None
 0.91A 5zcqA-2bwgA:
undetectable
5zcqJ-2bwgA:
undetectable		 5zcqA-2bwgA:
21.02
5zcqJ-2bwgA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4m GLYCOGEN
PHOSPHORYLASE

(Corynebacterium
callunae) 		PF00343
(Phosphorylase) 		4 ILE A 491
LEU A 488
THR A 457
LEU A 456
 None
 0.89A 5zcqA-2c4mA:
2.2
5zcqJ-2c4mA:
undetectable		 5zcqA-2c4mA:
19.75
5zcqJ-2c4mA:
6.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eg5 XANTHOSINE
METHYLTRANSFERASE

(Coffea
canephora) 		PF03492
(Methyltransf_7) 		4 ILE A 287
LEU A 363
THR A 292
LEU A 359
 None
 0.93A 5zcqA-2eg5A:
undetectable
5zcqJ-2eg5A:
undetectable		 5zcqA-2eg5A:
22.14
5zcqJ-2eg5A:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fbi PROBABLE
TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		PF01047
(MarR) 		4 ARG A  62
MET A  65
THR A  66
LEU A  69
 None
 0.88A 5zcqA-2fbiA:
undetectable
5zcqJ-2fbiA:
undetectable		 5zcqA-2fbiA:
13.47
5zcqJ-2fbiA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		4 LEU A 109
MET A 164
THR A 165
LEU A 168
 None
 0.74A 5zcqA-2hnzA:
2.2
5zcqJ-2hnzA:
undetectable		 5zcqA-2hnzA:
19.77
5zcqJ-2hnzA:
6.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ihy ABC TRANSPORTER,
ATP-BINDING PROTEIN

(Staphylococcus
aureus) 		PF00005
(ABC_tran) 		4 ILE A 184
LEU A 188
ARG A 178
LEU A 166
 None
 0.91A 5zcqA-2ihyA:
undetectable
5zcqJ-2ihyA:
undetectable		 5zcqA-2ihyA:
19.92
5zcqJ-2ihyA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iy8 PROTEIN PM0188

(Pasteurella
multocida) 		PF11477
(PM0188) 		4 ILE A 117
LEU A 121
ARG A 186
LEU A 168
 None
 0.95A 5zcqA-2iy8A:
undetectable
5zcqJ-2iy8A:
undetectable		 5zcqA-2iy8A:
22.50
5zcqJ-2iy8A:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kbq HARMONIN

(Homo sapiens) 		no annotation 4 ILE A  50
LEU A  58
TYR A  74
LEU A  30
 None
 0.81A 5zcqA-2kbqA:
undetectable
5zcqJ-2kbqA:
undetectable		 5zcqA-2kbqA:
8.84
5zcqJ-2kbqA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lf8 TRANSCRIPTION FACTOR
ETV6

(Mus musculus) 		PF00178
(Ets) 		4 ILE A 366
LEU A 372
ARG A 395
LEU A 337
 None
 0.92A 5zcqA-2lf8A:
undetectable
5zcqJ-2lf8A:
undetectable		 5zcqA-2lf8A:
12.14
5zcqJ-2lf8A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozg GCN5-RELATED
N-ACETYLTRANSFERASE

(Trichormus
variabilis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		4 ILE A  25
LEU A  22
ARG A  54
LEU A  99
 None
 0.89A 5zcqA-2ozgA:
undetectable
5zcqJ-2ozgA:
undetectable		 5zcqA-2ozgA:
21.72
5zcqJ-2ozgA:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0d RHO
GTPASE-ACTIVATING
PROTEIN 9

(Homo sapiens) 		PF00169
(PH) 		4 ILE A 405
LEU A 390
THR A 353
LEU A 352
 None
 0.76A 5zcqA-2p0dA:
undetectable
5zcqJ-2p0dA:
undetectable		 5zcqA-2p0dA:
12.67
5zcqJ-2p0dA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE X 252
MET X 356
THR X 357
LEU X 360
 None
 0.78A 5zcqA-2p3gX:
undetectable
5zcqJ-2p3gX:
undetectable		 5zcqA-2p3gX:
19.81
5zcqJ-2p3gX:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjw UNCHARACTERIZED
PROTEIN XCC1541

(Xanthomonas
campestris) 		no annotation 4 ILE A 121
LEU A  99
THR A 106
LEU A 114
 None
 0.89A 5zcqA-2qjwA:
undetectable
5zcqJ-2qjwA:
undetectable		 5zcqA-2qjwA:
16.20
5zcqJ-2qjwA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rdl CHYMASE 2

(Mesocricetus
auratus) 		PF00089
(Trypsin) 		4 ILE A 231
ARG A  48
THR A 120
LEU A 121
 None
 0.96A 5zcqA-2rdlA:
undetectable
5zcqJ-2rdlA:
undetectable		 5zcqA-2rdlA:
17.87
5zcqJ-2rdlA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v1w PDZ AND LIM DOMAIN
PROTEIN 4

(Homo sapiens) 		PF00595
(PDZ) 		4 ILE A  69
LEU A  76
ARG A  16
LEU A  43
 None
 0.94A 5zcqA-2v1wA:
undetectable
5zcqJ-2v1wA:
undetectable		 5zcqA-2v1wA:
10.44
5zcqJ-2v1wA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2whk MANNAN
ENDO-1,4-BETA-MANNOS
IDASE

(Bacillus
subtilis) 		PF02156
(Glyco_hydro_26) 		4 ILE A 102
MET A 202
THR A 203
LEU A 208
 None
 0.97A 5zcqA-2whkA:
undetectable
5zcqJ-2whkA:
undetectable		 5zcqA-2whkA:
21.47
5zcqJ-2whkA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y24 XYLANASE

(Dickeya
chrysanthemi) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		4 ILE A  75
LEU A  77
THR A  60
LEU A  59
 None
 0.75A 5zcqA-2y24A:
undetectable
5zcqJ-2y24A:
undetectable		 5zcqA-2y24A:
22.63
5zcqJ-2y24A:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y69 CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1

(Bos taurus) 		PF02238
(COX7a) 		4 TYR J  32
MET J  36
THR J  37
LEU J  40
 None
 0.00A 5zcqA-2y69J:
undetectable
5zcqJ-2y69J:
7.9		 5zcqA-2y69J:
10.31
5zcqJ-2y69J:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z0f PUTATIVE
PHOSPHOGLUCOMUTASE

(Thermus
thermophilus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 ILE A  48
ARG A  32
THR A 128
LEU A 127
 None
 0.97A 5zcqA-2z0fA:
undetectable
5zcqJ-2z0fA:
undetectable		 5zcqA-2z0fA:
24.11
5zcqJ-2z0fA:
7.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ziu MUS81 PROTEIN

(Danio rerio) 		PF02732
(ERCC4) 		4 TYR A 471
MET A 475
THR A 476
LEU A 479
 None
 0.84A 5zcqA-2ziuA:
undetectable
5zcqJ-2ziuA:
undetectable		 5zcqA-2ziuA:
18.55
5zcqJ-2ziuA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zsg AMINOPEPTIDASE P,
PUTATIVE

(Thermotoga
maritima) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		5 ILE A 230
ARG A 151
MET A 177
THR A 176
LEU A 173
 None
 0.96A 5zcqA-2zsgA:
2.2
5zcqJ-2zsgA:
undetectable		 5zcqA-2zsgA:
20.79
5zcqJ-2zsgA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2d CD180 ANTIGEN

(Homo sapiens) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		4 LEU A 503
ARG A 472
MET A 522
LEU A 519
 None
 0.94A 5zcqA-3b2dA:
undetectable
5zcqJ-3b2dA:
undetectable		 5zcqA-3b2dA:
20.65
5zcqJ-3b2dA:
7.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bn1 PEROSAMINE
SYNTHETASE

(Caulobacter
vibrioides) 		PF01041
(DegT_DnrJ_EryC1) 		4 ILE A 312
TYR A 261
THR A 289
LEU A 346
 None
 0.95A 5zcqA-3bn1A:
undetectable
5zcqJ-3bn1A:
undetectable		 5zcqA-3bn1A:
21.12
5zcqJ-3bn1A:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bop BETA-NEUREXIN 2D4

(Mus musculus) 		PF02210
(Laminin_G_2) 		4 ILE A 217
LEU A 233
ARG A 252
THR A 101
 None
 0.92A 5zcqA-3bopA:
undetectable
5zcqJ-3bopA:
undetectable		 5zcqA-3bopA:
15.56
5zcqJ-3bopA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bz6 UPF0502 PROTEIN
PSPTO_2686

(Pseudomonas
syringae group
genomosp. 3) 		PF04337
(DUF480) 		4 ILE A 172
LEU A  17
ARG A  25
LEU A  76
 None
 0.85A 5zcqA-3bz6A:
undetectable
5zcqJ-3bz6A:
undetectable		 5zcqA-3bz6A:
15.42
5zcqJ-3bz6A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c9b VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 75

(Saccharomyces
cerevisiae) 		PF00956
(NAP) 		4 ILE A  80
LEU A  62
ARG A  73
LEU A 200
 None
 0.74A 5zcqA-3c9bA:
1.6
5zcqJ-3c9bA:
undetectable		 5zcqA-3c9bA:
16.41
5zcqJ-3c9bA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ced METHIONINE IMPORT
ATP-BINDING PROTEIN
METN 2

(Staphylococcus
aureus) 		PF09383
(NIL) 		4 ILE A 313
ARG A 267
MET A 335
LEU A 328
 None
 0.97A 5zcqA-3cedA:
undetectable
5zcqJ-3cedA:
undetectable		 5zcqA-3cedA:
11.49
5zcqJ-3cedA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dka DINB-LIKE PROTEIN

(Bacillus
subtilis) 		PF05163
(DinB) 		4 ILE A 105
LEU A 120
THR A  97
LEU A  96
 None
 0.91A 5zcqA-3dkaA:
2.8
5zcqJ-3dkaA:
undetectable		 5zcqA-3dkaA:
13.42
5zcqJ-3dkaA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dni DEOXYRIBONUCLEASE I

(Bos taurus) 		PF03372
(Exo_endo_phos) 		4 ILE A  37
LEU A  81
ARG A  31
LEU A  55
 None
 0.97A 5zcqA-3dniA:
undetectable
5zcqJ-3dniA:
undetectable		 5zcqA-3dniA:
17.90
5zcqJ-3dniA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7f 6-PHOSPHOGLUCONOLACT
ONASE

(Trypanosoma
brucei) 		PF01182
(Glucosamine_iso) 		4 ILE A 230
LEU A 231
THR A 219
LEU A 255
 None
 0.85A 5zcqA-3e7fA:
undetectable
5zcqJ-3e7fA:
undetectable		 5zcqA-3e7fA:
19.65
5zcqJ-3e7fA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ezu GGDEF DOMAIN PROTEIN

(Geobacter
sulfurreducens) 		PF00990
(GGDEF) 		4 ILE A 246
ARG A 284
THR A 298
LEU A 220
 None
 0.97A 5zcqA-3ezuA:
undetectable
5zcqJ-3ezuA:
undetectable		 5zcqA-3ezuA:
21.10
5zcqJ-3ezuA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ezx MONOMETHYLAMINE
CORRINOID PROTEIN 1

(Methanosarcina
barkeri) 		PF02310
(B12-binding)
PF02607
(B12-binding_2) 		4 ILE A  40
LEU A  37
ARG A 111
THR A 114
 None
 0.90A 5zcqA-3ezxA:
undetectable
5zcqJ-3ezxA:
undetectable		 5zcqA-3ezxA:
18.16
5zcqJ-3ezxA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fss HISTONE CHAPERONE
RTT106

(Saccharomyces
cerevisiae) 		PF08512
(Rtt106) 		4 ILE A 200
MET A 158
THR A 159
LEU A 160
 None
 0.94A 5zcqA-3fssA:
undetectable
5zcqJ-3fssA:
undetectable		 5zcqA-3fssA:
19.04
5zcqJ-3fssA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gju PUTATIVE
AMINOTRANSFERASE

(Mesorhizobium
japonicum) 		PF00202
(Aminotran_3) 		4 ILE A 131
MET A 159
THR A 160
LEU A 163
 None
 0.87A 5zcqA-3gjuA:
undetectable
5zcqJ-3gjuA:
undetectable		 5zcqA-3gjuA:
22.26
5zcqJ-3gjuA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5t TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Corynebacterium
glutamicum) 		PF00356
(LacI)
PF13377
(Peripla_BP_3) 		4 ILE A 147
LEU A 152
THR A 331
LEU A 332
 None
 0.77A 5zcqA-3h5tA:
undetectable
5zcqJ-3h5tA:
undetectable		 5zcqA-3h5tA:
21.02
5zcqJ-3h5tA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hve GIGAXONIN

(Homo sapiens) 		PF00651
(BTB)
PF07707
(BACK) 		4 ILE A  55
LEU A  48
THR A 115
LEU A 114
 None
 0.96A 5zcqA-3hveA:
2.5
5zcqJ-3hveA:
undetectable		 5zcqA-3hveA:
17.61
5zcqJ-3hveA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF11

(Schizosaccharomyces
pombe) 		PF13087
(AAA_12)
PF16399
(Aquarius_N) 		4 ILE X 989
MET X 745
THR X 744
LEU X 743
 None
 0.91A 5zcqA-3jb9X:
undetectable
5zcqJ-3jb9X:
undetectable		 5zcqA-3jb9X:
16.83
5zcqJ-3jb9X:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1r HARMONIN

(Homo sapiens) 		PF00595
(PDZ) 		4 ILE A  50
LEU A  58
TYR A  74
LEU A  30
 None
 0.86A 5zcqA-3k1rA:
undetectable
5zcqJ-3k1rA:
undetectable		 5zcqA-3k1rA:
14.45
5zcqJ-3k1rA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfu ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B

(Thermus
thermophilus) 		PF02637
(GatB_Yqey)
PF02934
(GatB_N) 		4 ILE F 166
LEU F 163
ARG F 111
LEU F 153
 None
 0.74A 5zcqA-3kfuF:
undetectable
5zcqJ-3kfuF:
undetectable		 5zcqA-3kfuF:
18.69
5zcqJ-3kfuF:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl7 PUTATIVE
METAL-DEPENDENT
HYDROLASE

(Parabacteroides
distasonis) 		PF13483
(Lactamase_B_3) 		4 ILE A 101
MET A 128
THR A 157
LEU A 156
 None
None
GOL  A 306 (-4.7A)
None
 0.88A 5zcqA-3kl7A:
undetectable
5zcqJ-3kl7A:
undetectable		 5zcqA-3kl7A:
16.47
5zcqJ-3kl7A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kyj CHEY6 PROTEIN

(Rhodobacter
sphaeroides) 		PF00072
(Response_reg) 		4 ILE B   7
MET B 128
THR B 127
LEU B 124
 None
 0.93A 5zcqA-3kyjB:
undetectable
5zcqJ-3kyjB:
undetectable		 5zcqA-3kyjB:
15.09
5zcqJ-3kyjB:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lax PHENYLACETATE-COENZY
ME A LIGASE

(Bacteroides
vulgatus) 		PF14535
(AMP-binding_C_2) 		4 ILE A 358
ARG A 406
THR A 394
LEU A 397
 None
 0.92A 5zcqA-3laxA:
undetectable
5zcqJ-3laxA:
undetectable		 5zcqA-3laxA:
11.47
5zcqJ-3laxA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mhu DIHYDROOROTATE
DEHYDROGENASE

(Leishmania
major) 		PF01180
(DHO_dh) 		4 ILE A 181
TYR A 169
MET A 166
LEU A 129
 None
 0.97A 5zcqA-3mhuA:
undetectable
5zcqJ-3mhuA:
undetectable		 5zcqA-3mhuA:
20.19
5zcqJ-3mhuA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o4z TELOMERE LENGTH
REGULATION PROTEIN
TEL2

(Saccharomyces
cerevisiae) 		PF10193
(Telomere_reg-2) 		4 ILE A 225
LEU A 222
ARG A 243
LEU A 246
 None
 0.92A 5zcqA-3o4zA:
2.4
5zcqJ-3o4zA:
undetectable		 5zcqA-3o4zA:
21.65
5zcqJ-3o4zA:
6.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o6o HEAT SHOCK PROTEIN
83

(Trypanosoma
brucei) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		4 ILE A 192
ARG A  64
THR A  75
LEU A  74
 None
 0.98A 5zcqA-3o6oA:
undetectable
5zcqJ-3o6oA:
undetectable		 5zcqA-3o6oA:
17.96
5zcqJ-3o6oA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8c NCK-ASSOCIATED
PROTEIN 1

(Homo sapiens) 		PF09735
(Nckap1) 		4 LEU B 682
ARG B 705
THR B 709
LEU B 712
 None
 0.83A 5zcqA-3p8cB:
3.6
5zcqJ-3p8cB:
undetectable		 5zcqA-3p8cB:
18.35
5zcqJ-3p8cB:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pf2 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
agalactiae) 		PF16569
(GramPos_pilinBB)
PF16570
(GramPos_pilinD3) 		4 ILE A 236
LEU A 240
THR A 270
LEU A 271
 None
 0.77A 5zcqA-3pf2A:
undetectable
5zcqJ-3pf2A:
undetectable		 5zcqA-3pf2A:
18.65
5zcqJ-3pf2A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pty ARABINOSYLTRANSFERAS
E C

(Mycobacterium
tuberculosis) 		PF14896
(Arabino_trans_C) 		4 ILE A 936
LEU A 933
ARG A 944
LEU A 766
 None
 0.97A 5zcqA-3ptyA:
undetectable
5zcqJ-3ptyA:
undetectable		 5zcqA-3ptyA:
22.01
5zcqJ-3ptyA:
8.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rr1 PUTATIVE
D-GALACTONATE
DEHYDRATASE

(Ralstonia
pickettii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A  93
LEU A  90
THR A   7
LEU A   6
 None
 0.71A 5zcqA-3rr1A:
undetectable
5zcqJ-3rr1A:
undetectable		 5zcqA-3rr1A:
22.10
5zcqJ-3rr1A:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3se7 VANA

(-) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 TYR A 315
MET A 319
THR A 320
LEU A 324
 None
 0.94A 5zcqA-3se7A:
undetectable
5zcqJ-3se7A:
undetectable		 5zcqA-3se7A:
21.97
5zcqJ-3se7A:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sut BETA-HEXOSAMINIDASE

(Paenibacillus
sp. TS12) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b) 		4 ILE A  40
LEU A  60
THR A  35
LEU A  34
 None
 0.92A 5zcqA-3sutA:
undetectable
5zcqJ-3sutA:
undetectable		 5zcqA-3sutA:
23.64
5zcqJ-3sutA:
8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6q CD180 ANTIGEN

(Mus musculus) 		PF13855
(LRR_8) 		4 ILE A 352
LEU A 377
THR A 348
LEU A 372
 None
 0.92A 5zcqA-3t6qA:
undetectable
5zcqJ-3t6qA:
undetectable		 5zcqA-3t6qA:
19.07
5zcqJ-3t6qA:
7.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tcq MATRIX PROTEIN VP40

(Sudan
ebolavirus) 		PF07447
(VP40) 		4 LEU A 147
TYR A 120
ARG A  52
LEU A 181
 None
 0.96A 5zcqA-3tcqA:
undetectable
5zcqJ-3tcqA:
undetectable		 5zcqA-3tcqA:
20.38
5zcqJ-3tcqA:
8.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v85 CYTH-LIKE
PHOSPHATASE

(Arabidopsis
thaliana) 		PF01928
(CYTH) 		4 ILE A 191
LEU A 186
THR A  23
LEU A  22
 None
 0.90A 5zcqA-3v85A:
undetectable
5zcqJ-3v85A:
undetectable		 5zcqA-3v85A:
17.05
5zcqJ-3v85A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3we7 PUTATIVE
UNCHARACTERIZED
PROTEIN PH0499

(Pyrococcus
horikoshii) 		PF02585
(PIG-L) 		4 ILE A 192
ARG A 125
THR A 129
LEU A 132
 None
 0.79A 5zcqA-3we7A:
undetectable
5zcqJ-3we7A:
undetectable		 5zcqA-3we7A:
18.46
5zcqJ-3we7A:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wib HALOALKANE
DEHALOGENASE

(Agrobacterium
fabrum) 		PF00561
(Abhydrolase_1) 		4 ILE A 261
LEU A 264
THR A 250
LEU A 249
 None
 0.91A 5zcqA-3wibA:
undetectable
5zcqJ-3wibA:
undetectable		 5zcqA-3wibA:
20.31
5zcqJ-3wibA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1l CRISPR SYSTEM CMR
SUBUNIT CMR2

(Pyrococcus
furiosus) 		PF12469
(DUF3692) 		4 ILE A 226
LEU A 249
ARG A 321
LEU A 326
 None
 0.90A 5zcqA-3x1lA:
undetectable
5zcqJ-3x1lA:
undetectable		 5zcqA-3x1lA:
19.89
5zcqJ-3x1lA:
6.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b4o EPIMERASE FAMILY
PROTEIN SDR39U1

(Homo sapiens) 		PF01370
(Epimerase)
PF08338
(DUF1731) 		4 ILE A 193
TYR A 277
THR A 203
LEU A 202
 None
 0.92A 5zcqA-4b4oA:
undetectable
5zcqJ-4b4oA:
undetectable		 5zcqA-4b4oA:
22.69
5zcqJ-4b4oA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8c GLUCOSE-REPRESSIBLE
ALCOHOL
DEHYDROGENASE
TRANSCRIPTIONAL
EFFECTOR

(Saccharomyces
cerevisiae) 		PF03372
(Exo_endo_phos)
PF13855
(LRR_8) 		4 ILE D 376
LEU D 399
THR D 370
LEU D 392
 None
 0.85A 5zcqA-4b8cD:
undetectable
5zcqJ-4b8cD:
undetectable		 5zcqA-4b8cD:
21.05
5zcqJ-4b8cD:
6.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4egw MAGNESIUM TRANSPORT
PROTEIN CORA

(Methanocaldococcus
jannaschii) 		PF01544
(CorA) 		4 ILE A  96
LEU A 101
ARG A 214
LEU A 140
 None
 0.96A 5zcqA-4egwA:
2.3
5zcqJ-4egwA:
undetectable		 5zcqA-4egwA:
18.58
5zcqJ-4egwA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fcg UNCHARACTERIZED
PROTEIN

(Xanthomonas
euvesicatoria) 		PF13855
(LRR_8) 		4 ILE A 317
LEU A 312
ARG A 262
LEU A 264
 None
 0.94A 5zcqA-4fcgA:
undetectable
5zcqJ-4fcgA:
undetectable		 5zcqA-4fcgA:
19.77
5zcqJ-4fcgA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdd TRANSPORTIN-1

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		4 ILE A 440
ARG A 464
THR A 506
LEU A 507
 None
 0.81A 5zcqA-4fddA:
1.6
5zcqJ-4fddA:
undetectable		 5zcqA-4fddA:
20.07
5zcqJ-4fddA:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fmz INTERNALIN

(Listeria
monocytogenes) 		PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13855
(LRR_8) 		4 ILE A 128
LEU A 150
THR A 124
LEU A 145
 None
 0.88A 5zcqA-4fmzA:
undetectable
5zcqJ-4fmzA:
undetectable		 5zcqA-4fmzA:
20.75
5zcqJ-4fmzA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxb PUTATIVE CYTOCHROME
P450

(Streptomyces
coelicolor) 		PF00067
(p450) 		4 ILE A 163
LEU A 167
ARG A 182
LEU A 201
 HEM  A 501 ( 4.7A)
None
None
None
 0.96A 5zcqA-4fxbA:
undetectable
5zcqJ-4fxbA:
undetectable		 5zcqA-4fxbA:
21.70
5zcqJ-4fxbA:
8.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hc6 HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE

(Mycobacterium
tuberculosis) 		PF01648
(ACPS) 		4 ILE A  61
ARG A  81
THR A  98
LEU A  97
 None
 0.91A 5zcqA-4hc6A:
undetectable
5zcqJ-4hc6A:
undetectable		 5zcqA-4hc6A:
14.37
5zcqJ-4hc6A:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htf S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE

(Escherichia
coli) 		PF13847
(Methyltransf_31) 		4 ILE B 116
LEU B 135
THR B 111
LEU B 109
 None
 0.94A 5zcqA-4htfB:
undetectable
5zcqJ-4htfB:
undetectable		 5zcqA-4htfB:
18.97
5zcqJ-4htfB:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hz8 BETA-GLUCOSIDASE

(uncultured
bacterium) 		PF00232
(Glyco_hydro_1) 		4 ILE A 452
ARG A 114
THR A 112
LEU A 110
 None
 0.98A 5zcqA-4hz8A:
undetectable
5zcqJ-4hz8A:
undetectable		 5zcqA-4hz8A:
22.08
5zcqJ-4hz8A:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN

(Lactobacillus
acidophilus) 		PF06100
(MCRA) 		4 ILE A 410
LEU A 438
MET A 458
LEU A 351
 None
 0.90A 5zcqA-4ia5A:
undetectable
5zcqJ-4ia5A:
undetectable		 5zcqA-4ia5A:
21.70
5zcqJ-4ia5A:
8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igu CG5036

(Drosophila
melanogaster) 		PF00615
(RGS) 		4 ILE A 119
LEU A 122
ARG A  36
LEU A  43
 None
 0.87A 5zcqA-4iguA:
undetectable
5zcqJ-4iguA:
undetectable		 5zcqA-4iguA:
13.31
5zcqJ-4iguA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ir8 SEDOHEPTULOSE-1,7
BISPHOSPHATASE,
PUTATIVE

(Toxoplasma
gondii) 		PF00316
(FBPase) 		4 ILE A  27
LEU A  23
ARG A  33
LEU A 104
 None
 0.94A 5zcqA-4ir8A:
undetectable
5zcqJ-4ir8A:
undetectable		 5zcqA-4ir8A:
19.66
5zcqJ-4ir8A:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j80 CHAPERONE PROTEIN
DNAJ 2

(Thermus
thermophilus) 		PF00226
(DnaJ)
PF01556
(DnaJ_C) 		4 ILE A 152
LEU A 169
ARG A 147
LEU A 118
 None
 0.92A 5zcqA-4j80A:
undetectable
5zcqJ-4j80A:
undetectable		 5zcqA-4j80A:
18.79
5zcqJ-4j80A:
10.92