SIMILAR PATTERNS OF AMINO ACIDS FOR 5ZCP_C_CHDC306

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eco ERYTHROCRUORIN
(CARBONMONOXY)

(Chironomus
thummi) 		PF00042
(Globin) 		4 GLN A  10
PHE A  13
LEU A 125
PHE A 129
 None
 1.09A 5zcpC-1ecoA:
undetectable
5zcpJ-1ecoA:
0.0		 5zcpC-1ecoA:
20.00
5zcpJ-1ecoA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fdj FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE

(Oryctolagus
cuniculus) 		PF00274
(Glycolytic) 		4 GLN A1336
PHE A1299
LEU A1305
PHE A1327
 None
 1.03A 5zcpC-1fdjA:
undetectable
5zcpJ-1fdjA:
0.0		 5zcpC-1fdjA:
18.85
5zcpJ-1fdjA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gkr NON-ATP DEPENDENT
L-SELECTIVE
HYDANTOINASE

(Paenarthrobacter
aurescens) 		PF01979
(Amidohydro_1) 		4 GLN A 115
PHE A 121
LEU A 123
PHE A 106
 None
 1.12A 5zcpC-1gkrA:
undetectable
5zcpJ-1gkrA:
0.0		 5zcpC-1gkrA:
18.57
5zcpJ-1gkrA:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2t 80 KDA NUCLEAR CAP
BINDING PROTEIN

(Homo sapiens) 		PF02854
(MIF4G)
PF09088
(MIF4G_like)
PF09090
(MIF4G_like_2) 		4 GLN C 783
PHE C 782
PHE C 751
LEU C 747
 None
 0.99A 5zcpC-1h2tC:
4.3
5zcpJ-1h2tC:
0.0		 5zcpC-1h2tC:
14.50
5zcpJ-1h2tC:
7.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hfu LACCASE 1

(Coprinopsis
cinerea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 GLN A 381
PHE A 440
LEU A 385
PHE A 331
 None
None
None
NAG  A 602 ( 4.5A)
 0.98A 5zcpC-1hfuA:
undetectable
5zcpJ-1hfuA:
0.0		 5zcpC-1hfuA:
19.76
5zcpJ-1hfuA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nrv GROWTH FACTOR
RECEPTOR-BOUND
PROTEIN 10

(Homo sapiens) 		PF00017
(SH2) 		4 GLN A 485
PHE A 484
LEU A 512
PHE A 506
 None
 1.01A 5zcpC-1nrvA:
undetectable
5zcpJ-1nrvA:
undetectable		 5zcpC-1nrvA:
16.86
5zcpJ-1nrvA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6u TRYPTOPHANYL-TRNA
SYNTHETASE

(Homo sapiens) 		PF00579
(tRNA-synt_1b) 		4 GLN A 304
PHE A 187
LEU A 183
PHE A 179
 None
 1.03A 5zcpC-1r6uA:
undetectable
5zcpJ-1r6uA:
0.0		 5zcpC-1r6uA:
17.83
5zcpJ-1r6uA:
7.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svr SEVERIN

(Dictyostelium
discoideum) 		PF00626
(Gelsolin) 		4 GLN A 200
PHE A 201
PHE A 245
LEU A 249
 None
 0.77A 5zcpC-1svrA:
undetectable
5zcpJ-1svrA:
undetectable		 5zcpC-1svrA:
17.37
5zcpJ-1svrA:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tp6 HYPOTHETICAL PROTEIN
PA1314

(Pseudomonas
aeruginosa) 		PF14534
(DUF4440) 		4 GLN A 123
PHE A  40
LEU A  55
PHE A  59
 None
 1.01A 5zcpC-1tp6A:
undetectable
5zcpJ-1tp6A:
0.0		 5zcpC-1tp6A:
21.19
5zcpJ-1tp6A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tzn ANTHRAX TOXIN
RECEPTOR 2

(Homo sapiens) 		PF03495
(Binary_toxB)
PF17475
(Binary_toxB_2)
PF17476
(Binary_toxB_3) 		4 GLN a1068
PHE a1065
PHE a1047
LEU a1080
 None
 1.01A 5zcpC-1tzna:
0.0
5zcpJ-1tzna:
undetectable		 5zcpC-1tzna:
20.80
5zcpJ-1tzna:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vax URIC ACID OXIDASE

(Arthrobacter
globiformis) 		PF01014
(Uricase) 		4 GLN A  47
PHE A  96
LEU A  92
PHE A  88
 None
 1.11A 5zcpC-1vaxA:
0.2
5zcpJ-1vaxA:
undetectable		 5zcpC-1vaxA:
20.98
5zcpJ-1vaxA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vfn PURINE-NUCLEOSIDE
PHOSPHORYLASE

(Bos taurus) 		PF01048
(PNP_UDP_1) 		4 PHE A  98
PHE A  56
LEU A  68
PHE A  70
 None
 1.00A 5zcpC-1vfnA:
undetectable
5zcpJ-1vfnA:
undetectable		 5zcpC-1vfnA:
24.03
5zcpJ-1vfnA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xho CHORISMATE MUTASE

(Ruminiclostridium
thermocellum) 		PF07736
(CM_1) 		4 ARG A  62
GLN A  24
PHE A  46
LEU A  71
 None
 0.92A 5zcpC-1xhoA:
undetectable
5zcpJ-1xhoA:
undetectable		 5zcpC-1xhoA:
17.72
5zcpJ-1xhoA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xw8 UPF0271 PROTEIN YBGL

(Escherichia
coli) 		PF03746
(LamB_YcsF) 		4 GLN A 186
PHE A 227
LEU A 231
PHE A 235
 None
 0.82A 5zcpC-1xw8A:
undetectable
5zcpJ-1xw8A:
undetectable		 5zcpC-1xw8A:
18.97
5zcpJ-1xw8A:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aeu HYPOTHETICAL PROTEIN
MJ0158

(Methanocaldococcus
jannaschii) 		PF03841
(SelA) 		4 GLN A 191
PHE A 189
LEU A 256
PHE A 254
 None
 1.11A 5zcpC-2aeuA:
undetectable
5zcpJ-2aeuA:
undetectable		 5zcpC-2aeuA:
20.26
5zcpJ-2aeuA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bl0 MYOSIN REGULATORY
LIGHT CHAIN

(Physarum
polycephalum) 		PF13833
(EF-hand_8) 		4 PHE C 148
PHE C 132
LEU C 113
PHE C 100
 None
 1.02A 5zcpC-2bl0C:
undetectable
5zcpJ-2bl0C:
undetectable		 5zcpC-2bl0C:
21.40
5zcpJ-2bl0C:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d6l LECTIN, GALACTOSE
BINDING, SOLUBLE 9

(Mus musculus) 		PF00337
(Gal-bind_lectin) 		4 GLN X  89
PHE X  92
LEU X 100
PHE X 102
 None
 0.98A 5zcpC-2d6lX:
undetectable
5zcpJ-2d6lX:
undetectable		 5zcpC-2d6lX:
21.43
5zcpJ-2d6lX:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2egr HYPOTHETICAL PROTEIN
AQ_1494

(Aquifex
aeolicus) 		PF03061
(4HBT) 		4 PHE A  87
PHE A  89
LEU A  77
PHE A   3
 None
 1.10A 5zcpC-2egrA:
undetectable
5zcpJ-2egrA:
undetectable		 5zcpC-2egrA:
18.08
5zcpJ-2egrA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g8g CAPSID

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		4 GLN A 644
PHE A 275
LEU A 353
PHE A 361
 None
 1.06A 5zcpC-2g8gA:
undetectable
5zcpJ-2g8gA:
undetectable		 5zcpC-2g8gA:
19.09
5zcpJ-2g8gA:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2in3 HYPOTHETICAL PROTEIN

(Nitrosomonas
europaea) 		PF01323
(DSBA) 		4 GLN A 117
PHE A 120
LEU A 133
PHE A 151
 None
 0.92A 5zcpC-2in3A:
undetectable
5zcpJ-2in3A:
undetectable		 5zcpC-2in3A:
22.22
5zcpJ-2in3A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inp PHENOL HYDROXYLASE
COMPONENT PHN

(Pseudomonas
stutzeri) 		PF02332
(Phenol_Hydrox)
PF04945
(YHS) 		4 ARG A 140
GLN A 146
PHE A  76
LEU A  72
 None
 0.98A 5zcpC-2inpA:
2.9
5zcpJ-2inpA:
undetectable		 5zcpC-2inpA:
18.12
5zcpJ-2inpA:
8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3t TRAFFICKING PROTEIN
PARTICLE COMPLEX
SUBUNIT 1

(Mus musculus) 		PF04099
(Sybindin) 		4 ARG C  94
GLN C  65
PHE C  64
PHE C  61
 None
 0.94A 5zcpC-2j3tC:
undetectable
5zcpJ-2j3tC:
undetectable		 5zcpC-2j3tC:
20.75
5zcpJ-2j3tC:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ml8 FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		no annotation 4 GLN A 214
PHE A 217
PHE A 194
LEU A 190
 None
 1.11A 5zcpC-2ml8A:
undetectable
5zcpJ-2ml8A:
undetectable		 5zcpC-2ml8A:
20.75
5zcpJ-2ml8A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE

(Nostoc
punctiforme) 		PF00221
(Lyase_aromatic) 		4 ARG A 490
GLN A 485
PHE A 482
LEU A 257
 None
 1.11A 5zcpC-2nyfA:
2.2
5zcpJ-2nyfA:
1.2		 5zcpC-2nyfA:
17.96
5zcpJ-2nyfA:
7.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1n SKP1-LIKE PROTEIN 1A
TRANSPORT INHIBITOR
RESPONSE 1 PROTEIN

(Arabidopsis
thaliana;
Arabidopsis
thaliana) 		PF01466
(Skp1)
PF03931
(Skp1_POZ)
PF12937
(F-box-like) 		4 PHE A  99
PHE B   9
LEU B  14
PHE B  18
 None
 0.96A 5zcpC-2p1nA:
undetectable
5zcpJ-2p1nA:
undetectable		 5zcpC-2p1nA:
18.58
5zcpJ-2p1nA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qpx PREDICTED
METAL-DEPENDENT
HYDROLASE OF THE
TIM-BARREL FOLD

(Lactobacillus
paracasei) 		PF04909
(Amidohydro_2) 		4 GLN A  10
PHE A   7
LEU A 336
PHE A 332
 None
 1.12A 5zcpC-2qpxA:
undetectable
5zcpJ-2qpxA:
undetectable		 5zcpC-2qpxA:
20.58
5zcpJ-2qpxA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyv XAA-HIS DIPEPTIDASE

(Histophilus
somni) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 GLN A 282
PHE A 233
LEU A 237
PHE A 244
 IPA  A 519 (-4.0A)
None
None
None
 1.05A 5zcpC-2qyvA:
undetectable
5zcpJ-2qyvA:
undetectable		 5zcpC-2qyvA:
18.70
5zcpJ-2qyvA:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w0i TWINFILIN-2

(Homo sapiens) 		PF00241
(Cofilin_ADF) 		4 PHE A 255
PHE A 238
LEU A 190
PHE A 287
 None
 1.10A 5zcpC-2w0iA:
undetectable
5zcpJ-2w0iA:
undetectable		 5zcpC-2w0iA:
19.83
5zcpJ-2w0iA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xvs TETRATRICOPEPTIDE
REPEAT PROTEIN 5

(Homo sapiens) 		PF16669
(TTC5_OB) 		4 ARG A 273
PHE A 343
LEU A 345
PHE A 270
 None
 1.10A 5zcpC-2xvsA:
undetectable
5zcpJ-2xvsA:
undetectable		 5zcpC-2xvsA:
19.25
5zcpJ-2xvsA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfu CARBOHYDRATE BINDING
FAMILY 6

(Ruminiclostridium
thermocellum) 		no annotation 4 GLN A  78
PHE A  77
PHE A 134
LEU A  47
 None
None
None
GOL  A1143 (-4.6A)
 1.06A 5zcpC-2yfuA:
undetectable
5zcpJ-2yfuA:
undetectable		 5zcpC-2yfuA:
19.85
5zcpJ-2yfuA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yvs GLYCOLATE OXIDASE
SUBUNIT GLCE

(Thermus
thermophilus) 		no annotation 4 ARG A  49
GLN A 200
LEU A  39
PHE A  52
 None
 0.95A 5zcpC-2yvsA:
undetectable
5zcpJ-2yvsA:
undetectable		 5zcpC-2yvsA:
20.59
5zcpJ-2yvsA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zu6 PROGRAMMED CELL
DEATH PROTEIN 4

(Homo sapiens) 		PF02847
(MA3) 		4 GLN B 263
PHE B 264
PHE B 240
LEU B 274
 None
 1.10A 5zcpC-2zu6B:
undetectable
5zcpJ-2zu6B:
undetectable		 5zcpC-2zu6B:
22.29
5zcpJ-2zu6B:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3i PENICILLIN-BINDING
PROTEIN 4

(Haemophilus
influenzae) 		PF02113
(Peptidase_S13) 		4 GLN A 235
PHE A 251
LEU A 249
PHE A 247
 None
 0.73A 5zcpC-3a3iA:
undetectable
5zcpJ-3a3iA:
undetectable		 5zcpC-3a3iA:
20.00
5zcpJ-3a3iA:
8.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ajf NON-STRUCTURAL
PROTEIN 3

(Rice hoja
blanca
tenuivirus) 		PF05310
(Tenui_NS3) 		4 GLN A  61
PHE A  54
LEU A  47
PHE A  43
 None
 1.04A 5zcpC-3ajfA:
undetectable
5zcpJ-3ajfA:
undetectable		 5zcpC-3ajfA:
19.07
5zcpJ-3ajfA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ay5 CYCLIN-D1-BINDING
PROTEIN 1

(Homo sapiens) 		PF13324
(GCIP) 		4 GLN A 161
PHE A  99
LEU A  56
PHE A  52
 None
 0.98A 5zcpC-3ay5A:
4.9
5zcpJ-3ay5A:
undetectable		 5zcpC-3ay5A:
21.94
5zcpJ-3ay5A:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ba3 PYRIDOXAMINE
5'-PHOSPHATE
OXIDASE-LIKE PROTEIN

(Lactobacillus
plantarum) 		no annotation 4 GLN A  87
PHE A 121
PHE A  45
LEU A  18
 None
 0.91A 5zcpC-3ba3A:
undetectable
5zcpJ-3ba3A:
undetectable		 5zcpC-3ba3A:
21.19
5zcpJ-3ba3A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bgh PUTATIVE
NEURAMINYLLACTOSE-BI
NDING HEMAGGLUTININ
HOMOLOG

(Helicobacter
pylori) 		PF05211
(NLBH) 		4 GLN A  78
PHE A  81
PHE A  44
LEU A  42
 None
 0.99A 5zcpC-3bghA:
2.1
5zcpJ-3bghA:
undetectable		 5zcpC-3bghA:
19.22
5zcpJ-3bghA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cm5 CELL DEATH-RELATED
NUCLEASE 4

(Caenorhabditis
elegans) 		PF00929
(RNase_T) 		4 GLN A 121
PHE A  16
LEU A  14
PHE A 108
 None
 1.05A 5zcpC-3cm5A:
undetectable
5zcpJ-3cm5A:
undetectable		 5zcpC-3cm5A:
20.55
5zcpJ-3cm5A:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3m EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2

(Homo sapiens) 		PF02020
(W2) 		4 GLN A 817
PHE A 776
LEU A 772
PHE A 768
 None
 1.06A 5zcpC-3d3mA:
undetectable
5zcpJ-3d3mA:
undetectable		 5zcpC-3d3mA:
21.29
5zcpJ-3d3mA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3foc TRYPTOPHANYL-TRNA
SYNTHETASE

(Giardia
intestinalis) 		PF00579
(tRNA-synt_1b) 		4 ARG A 161
GLN A 108
PHE A 148
LEU A 428
 None
 1.08A 5zcpC-3focA:
undetectable
5zcpJ-3focA:
undetectable		 5zcpC-3focA:
19.12
5zcpJ-3focA:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdb PUTATIVE
UNCHARACTERIZED
PROTEIN SPR0440

(Streptococcus
pneumoniae) 		PF03644
(Glyco_hydro_85) 		4 GLN A 731
PHE A 732
PHE A 713
LEU A 780
 None
 1.11A 5zcpC-3gdbA:
undetectable
5zcpJ-3gdbA:
undetectable		 5zcpC-3gdbA:
12.65
5zcpJ-3gdbA:
5.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3t UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 21

(Homo sapiens) 		PF00443
(UCH) 		4 GLN A 453
PHE A 397
LEU A 400
PHE A 420
 None
 1.05A 5zcpC-3i3tA:
undetectable
5zcpJ-3i3tA:
undetectable		 5zcpC-3i3tA:
21.07
5zcpJ-3i3tA:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jac PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1

(Mus musculus) 		PF12166
(Piezo_RRas_bdg) 		4 GLN A2389
PHE A2263
LEU A2259
PHE A2251
 None
 1.08A 5zcpC-3jacA:
undetectable
5zcpJ-3jacA:
1.7		 5zcpC-3jacA:
4.54
5zcpJ-3jacA:
7.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kf3 INVERTASE

(Schwanniomyces
occidentalis) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 GLN A  68
PHE A  67
LEU A 308
PHE A 298
 FRU  A 600 (-4.0A)
None
None
None
 1.01A 5zcpC-3kf3A:
undetectable
5zcpJ-3kf3A:
undetectable		 5zcpC-3kf3A:
19.12
5zcpJ-3kf3A:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus) 		PF01048
(PNP_UDP_1) 		4 PHE A  95
PHE A  53
LEU A  65
PHE A  67
 None
 1.01A 5zcpC-3khsA:
undetectable
5zcpJ-3khsA:
undetectable		 5zcpC-3khsA:
21.71
5zcpJ-3khsA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l8q CELLULOSOMAL
SCAFFOLDIN ADAPTOR
PROTEIN B

(Acetivibrio
cellulolyticus) 		PF00963
(Cohesin) 		4 ARG A 102
GLN A 109
PHE A  34
LEU A  98
 None
 1.10A 5zcpC-3l8qA:
undetectable
5zcpJ-3l8qA:
undetectable		 5zcpC-3l8qA:
20.00
5zcpJ-3l8qA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogr BETA-GALACTOSIDASE

(Trichoderma
reesei) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 PHE A 327
PHE A 299
LEU A 296
PHE A 294
 None
 0.93A 5zcpC-3ogrA:
undetectable
5zcpJ-3ogrA:
undetectable		 5zcpC-3ogrA:
14.48
5zcpJ-3ogrA:
4.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oox PUTATIVE 2OG-FE(II)
OXYGENASE FAMILY
PROTEIN

(Caulobacter
vibrioides) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		4 PHE A  11
PHE A  21
LEU A  25
PHE A  29
 EDO  A 320 (-4.5A)
None
None
None
 0.98A 5zcpC-3ooxA:
undetectable
5zcpJ-3ooxA:
undetectable		 5zcpC-3ooxA:
19.64
5zcpJ-3ooxA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3op3 M-PHASE INDUCER
PHOSPHATASE 3

(Homo sapiens) 		PF00581
(Rhodanese) 		4 ARG A 392
GLN A 350
PHE A 375
LEU A 409
 SO4  A 464 (-4.1A)
SO4  A 463 (-3.3A)
None
None
 1.06A 5zcpC-3op3A:
undetectable
5zcpJ-3op3A:
undetectable		 5zcpC-3op3A:
20.52
5zcpJ-3op3A:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q33 HISTONE
ACETYLTRANSFERASE
RTT109

(Saccharomyces
cerevisiae) 		PF08214
(HAT_KAT11) 		4 ARG A 318
PHE A 311
LEU A 315
PHE A 321
 None
 1.11A 5zcpC-3q33A:
undetectable
5zcpJ-3q33A:
undetectable		 5zcpC-3q33A:
19.95
5zcpJ-3q33A:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4i PHOSPHOHYDROLASE
(MUTT/NUDIX FAMILY
PROTEIN)

(Bacillus cereus) 		PF00293
(NUDIX)
PF12535
(Nudix_N) 		4 PHE A 130
PHE A 148
LEU A  94
PHE A  83
 None
 1.01A 5zcpC-3q4iA:
3.5
5zcpJ-3q4iA:
undetectable		 5zcpC-3q4iA:
20.44
5zcpJ-3q4iA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4t ACTIVIN RECEPTOR
TYPE-2A

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLN A 227
PHE A 203
PHE A 221
LEU A 265
 None
 1.11A 5zcpC-3q4tA:
2.5
5zcpJ-3q4tA:
undetectable		 5zcpC-3q4tA:
19.57
5zcpJ-3q4tA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sk7 PROTEIN SEQA

(Vibrio cholerae) 		PF03925
(SeqA) 		4 GLN A 154
PHE A  88
LEU A  92
PHE A 103
 None
 1.07A 5zcpC-3sk7A:
undetectable
5zcpJ-3sk7A:
undetectable		 5zcpC-3sk7A:
16.48
5zcpJ-3sk7A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v44 TOLL-LIKE RECEPTOR
5B AND VARIABLE
LYMPHOCYTE RECEPTOR
B.61 CHIMERIC
PROTEIN

(Eptatretus
burgeri;
Danio rerio) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		4 PHE A 312
PHE A 315
LEU A 289
PHE A 250
 None
 1.11A 5zcpC-3v44A:
undetectable
5zcpJ-3v44A:
undetectable		 5zcpC-3v44A:
19.86
5zcpJ-3v44A:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wi3 DNA REPLICATION
REGULATOR SLD3

(Saccharomyces
cerevisiae) 		PF08639
(SLD3) 		4 GLN A 415
PHE A 412
LEU A 398
PHE A 393
 None
 0.98A 5zcpC-3wi3A:
1.7
5zcpJ-3wi3A:
undetectable		 5zcpC-3wi3A:
18.93
5zcpJ-3wi3A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a6o ALPHA-N-ACETYLGLUCOS
AMINIDASE FAMILY
PROTEIN

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C) 		4 GLN A1276
PHE A1275
PHE A1268
LEU A1266
 None
 0.96A 5zcpC-4a6oA:
undetectable
5zcpJ-4a6oA:
undetectable		 5zcpC-4a6oA:
19.10
5zcpJ-4a6oA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF04054
(Not1) 		4 GLN A2252
PHE A2251
LEU A2196
PHE A2192
 None
 1.06A 5zcpC-4c0dA:
2.6
5zcpJ-4c0dA:
undetectable		 5zcpC-4c0dA:
14.62
5zcpJ-4c0dA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d0o A-KINASE ANCHOR
PROTEIN 13

(Homo sapiens) 		PF00621
(RhoGEF) 		4 GLN A2008
PHE A2011
PHE A2057
LEU A2061
 None
 0.63A 5zcpC-4d0oA:
3.6
5zcpJ-4d0oA:
undetectable		 5zcpC-4d0oA:
17.79
5zcpJ-4d0oA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dgk PHYTOENE
DEHYDROGENASE

(Pantoea
ananatis) 		PF01593
(Amino_oxidase) 		4 GLN A 103
PHE A 183
LEU A 179
PHE A 113
 None
 0.99A 5zcpC-4dgkA:
undetectable
5zcpJ-4dgkA:
undetectable		 5zcpC-4dgkA:
19.15
5zcpJ-4dgkA:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dpz HRAS-LIKE SUPPRESSOR
2

(Homo sapiens) 		PF04970
(LRAT) 		4 ARG X2095
GLN X2102
PHE X2116
LEU X2120
 None
 0.91A 5zcpC-4dpzX:
undetectable
5zcpJ-4dpzX:
undetectable		 5zcpC-4dpzX:
18.93
5zcpJ-4dpzX:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fnq ALPHA-GALACTOSIDASE
AGAB

(Geobacillus
stearothermophilus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		4 GLN A 400
PHE A 408
LEU A 365
PHE A 343
 None
 1.11A 5zcpC-4fnqA:
undetectable
5zcpJ-4fnqA:
undetectable		 5zcpC-4fnqA:
18.23
5zcpJ-4fnqA:
6.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hqf THROMBOSPONDIN-RELAT
ED ANONYMOUS
PROTEIN, TRAP

(Plasmodium
falciparum) 		PF00092
(VWA) 		4 ARG A 176
GLN A 169
PHE A 198
LEU A 202
 None
 1.05A 5zcpC-4hqfA:
undetectable
5zcpJ-4hqfA:
undetectable		 5zcpC-4hqfA:
20.74
5zcpJ-4hqfA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1a RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE I

(Bacillus
subtilis) 		PF13424
(TPR_12) 		4 GLN A 276
PHE A 312
LEU A 308
PHE A 267
 None
 1.03A 5zcpC-4i1aA:
2.9
5zcpJ-4i1aA:
undetectable		 5zcpC-4i1aA:
22.11
5zcpJ-4i1aA:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j72 PHOSPHO-N-ACETYLMURA
MOYL-PENTAPEPTIDE-TR
ANSFERASE

(Aquifex
aeolicus) 		PF00953
(Glycos_transf_4)
PF10555
(MraY_sig1) 		4 PHE A 180
PHE A 177
LEU A 158
PHE A 160
 None
 0.96A 5zcpC-4j72A:
undetectable
5zcpJ-4j72A:
undetectable		 5zcpC-4j72A:
22.37
5zcpJ-4j72A:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4llf CAPSID PROTEIN

(Cucumber
necrosis virus) 		PF00729
(Viral_coat) 		4 GLN A 230
PHE A 154
LEU A 152
PHE A 149
 None
 0.84A 5zcpC-4llfA:
undetectable
5zcpJ-4llfA:
undetectable		 5zcpC-4llfA:
21.36
5zcpJ-4llfA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n5c CARGO-TRANSPORT
PROTEIN YPP1

(Saccharomyces
cerevisiae) 		no annotation 4 PHE A 245
PHE A 269
LEU A 273
PHE A 277
 None
 1.11A 5zcpC-4n5cA:
3.7
5zcpJ-4n5cA:
undetectable		 5zcpC-4n5cA:
14.04
5zcpJ-4n5cA:
6.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oya ADENYLATE CYCLASE
TYPE 10

(Homo sapiens) 		PF00211
(Guanylate_cyc) 		4 GLN A 375
PHE A 372
LEU A 299
PHE A 301
 None
 1.07A 5zcpC-4oyaA:
undetectable
5zcpJ-4oyaA:
undetectable		 5zcpC-4oyaA:
19.62
5zcpJ-4oyaA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ppm AMINOTRANSFERASE

(Serratia sp.
FS14) 		PF00202
(Aminotran_3) 		4 GLN A 741
PHE A 742
LEU A 718
PHE A 714
 None
 1.12A 5zcpC-4ppmA:
undetectable
5zcpJ-4ppmA:
undetectable		 5zcpC-4ppmA:
14.00
5zcpJ-4ppmA:
5.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rsl FRUCTOSYL PEPTIDE
OXIDASE

(Penicillium
terrenum) 		PF01266
(DAO) 		4 GLN A 245
PHE A 336
LEU A 333
PHE A 268
 None
 1.03A 5zcpC-4rslA:
undetectable
5zcpJ-4rslA:
undetectable		 5zcpC-4rslA:
18.68
5zcpJ-4rslA:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxl MOLYBDENUM ABC
TRANSPORTER,
PERIPLASMIC
MOLYBDENUM-BINDING
PROTEIN

(Vibrio cholerae) 		PF13531
(SBP_bac_11) 		4 GLN A 128
PHE A 119
LEU A 121
PHE A 207
 None
 1.10A 5zcpC-4rxlA:
undetectable
5zcpJ-4rxlA:
undetectable		 5zcpC-4rxlA:
20.55
5zcpJ-4rxlA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s15 NUCLEAR RECEPTOR
ROR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 GLN A 332
PHE A 511
LEU A 361
PHE A 365
 None
 1.12A 5zcpC-4s15A:
undetectable
5zcpJ-4s15A:
undetectable		 5zcpC-4s15A:
20.98
5zcpJ-4s15A:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ud4 POLY(A) RNA
POLYMERASE PROTEIN
CID1

(Schizosaccharomyces
pombe) 		PF01909
(NTP_transf_2)
PF03828
(PAP_assoc) 		4 PHE A 153
PHE A 130
LEU A 125
PHE A 121
 None
 1.06A 5zcpC-4ud4A:
undetectable
5zcpJ-4ud4A:
undetectable		 5zcpC-4ud4A:
19.95
5zcpJ-4ud4A:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wpx CELL DIVISION
CONTROL PROTEIN
31-LIKE PROTEIN

(Chaetomium
thermophilum) 		PF00036
(EF-hand_1)
PF13499
(EF-hand_7) 		4 ARG A  27
PHE A  50
PHE A  35
LEU A  34
 None
 0.99A 5zcpC-4wpxA:
undetectable
5zcpJ-4wpxA:
undetectable		 5zcpC-4wpxA:
21.84
5zcpJ-4wpxA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster) 		PF00209
(SNF) 		4 PHE A 489
PHE A 106
LEU A 105
PHE A 590
 None
 1.03A 5zcpC-4xnuA:
undetectable
5zcpJ-4xnuA:
undetectable		 5zcpC-4xnuA:
20.59
5zcpJ-4xnuA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b4s CHITOSANASE

(Mitsuaria
chitosanitabida) 		PF13647
(Glyco_hydro_80) 		4 PHE A  93
PHE A  85
LEU A 130
PHE A 123
 None
 0.76A 5zcpC-5b4sA:
undetectable
5zcpJ-5b4sA:
undetectable		 5zcpC-5b4sA:
22.65
5zcpJ-5b4sA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bza BETA-N-ACETYLHEXOSAM
INIDASE

(Thermotoga
neapolitana) 		PF00933
(Glyco_hydro_3) 		4 GLN A 460
PHE A 459
PHE A 378
LEU A 343
 None
 0.87A 5zcpC-5bzaA:
undetectable
5zcpJ-5bzaA:
undetectable		 5zcpC-5bzaA:
17.12
5zcpJ-5bzaA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c9h TELOMERASE REVERSE
TRANSCRIPTASE

(Tetrahymena
thermophila) 		PF12009
(Telomerase_RBD) 		4 GLN A 382
PHE A 379
LEU A 405
PHE A 401
 None
 0.93A 5zcpC-5c9hA:
undetectable
5zcpJ-5c9hA:
undetectable		 5zcpC-5c9hA:
18.61
5zcpJ-5c9hA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czw MYROILYSIN

(Myroides
profundi) 		PF01400
(Astacin) 		4 PHE A 127
PHE A  98
LEU A  58
PHE A  86
 None
None
None
MLY  A  70 ( 4.0A)
 1.00A 5zcpC-5czwA:
undetectable
5zcpJ-5czwA:
undetectable		 5zcpC-5czwA:
21.15
5zcpJ-5czwA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6p PLEXIN-B2

(Mus musculus) 		PF08337
(Plexin_cytopl) 		4 GLN A1803
PHE A1336
LEU A1340
PHE A1346
 None
 1.10A 5zcpC-5e6pA:
2.3
5zcpJ-5e6pA:
undetectable		 5zcpC-5e6pA:
16.96
5zcpJ-5e6pA:
8.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fr8 TONB-DEPENDENT
SIDEROPHORE RECEPTOR

(Acinetobacter
baumannii) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 GLN A 518
PHE A 517
LEU A 586
PHE A 588
 None
 1.11A 5zcpC-5fr8A:
undetectable
5zcpJ-5fr8A:
undetectable		 5zcpC-5fr8A:
16.67
5zcpJ-5fr8A:
5.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5huu ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
[UDP-FORMING]

(Candida
albicans) 		PF00982
(Glyco_transf_20) 		4 PHE A 174
PHE A 101
LEU A  97
PHE A  92
 None
 0.99A 5zcpC-5huuA:
undetectable
5zcpJ-5huuA:
undetectable		 5zcpC-5huuA:
19.58
5zcpJ-5huuA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hvm ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)

(Aspergillus
fumigatus) 		PF00982
(Glyco_transf_20) 		4 PHE A 182
PHE A 109
LEU A 105
PHE A 100
 None
 0.93A 5zcpC-5hvmA:
undetectable
5zcpJ-5hvmA:
undetectable		 5zcpC-5hvmA:
18.38
5zcpJ-5hvmA:
8.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5iy5 CYTOCHROME C OXIDASE
SUBUNIT 3

(Bos taurus) 		PF00510
(COX3) 		5 ARG C 156
GLN C 161
PHE C 164
PHE C 219
LEU C 223
 CHD  C 307 (-4.0A)
CHD  C 307 (-4.3A)
CHD  C 307 (-3.9A)
None
None
 0.69A 5zcpC-5iy5C:
37.5
5zcpJ-5iy5C:
undetectable		 5zcpC-5iy5C:
100.00
5zcpJ-5iy5C:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbk BETA-GLUCOSIDASE

(Trichoderma
harzianum) 		PF00232
(Glyco_hydro_1) 		4 GLN A   8
PHE A   7
PHE A 459
LEU A 455
 None
 1.12A 5zcpC-5jbkA:
undetectable
5zcpJ-5jbkA:
undetectable		 5zcpC-5jbkA:
19.83
5zcpJ-5jbkA:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ken C13C6 VARIABLE FAB
DOMAIN LIGHT CHAIN

(Homo sapiens) 		PF07686
(V-set) 		4 GLN I  89
PHE I  87
LEU I  73
PHE I  62
 None
 0.95A 5zcpC-5kenI:
undetectable
5zcpJ-5kenI:
undetectable		 5zcpC-5kenI:
17.44
5zcpJ-5kenI:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kku POLYKETIDE SYNTHASE
TYPE I

(Bacillus
amyloliquefaciens) 		PF14765
(PS-DH) 		4 GLN A  13
PHE A  11
PHE A  80
LEU A 114
 None
 1.03A 5zcpC-5kkuA:
undetectable
5zcpJ-5kkuA:
undetectable		 5zcpC-5kkuA:
20.12
5zcpJ-5kkuA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE GAMMA
SUBUNIT

(Aromatoleum
aromaticum) 		PF01968
(Hydantoinase_A)
PF05378
(Hydant_A_N) 		4 GLN B 537
PHE B 623
LEU B 620
PHE B 520
 None
 1.04A 5zcpC-5l9wB:
undetectable
5zcpJ-5l9wB:
undetectable		 5zcpC-5l9wB:
15.98
5zcpJ-5l9wB:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ltm PHENYLALANINE
AMMONIA LYASE

(Anabaena) 		no annotation 4 ARG B 490
GLN B 485
PHE B 482
LEU B 257
 None
 1.08A 5zcpC-5ltmB:
3.8
5zcpJ-5ltmB:
undetectable		 5zcpC-5ltmB:
18.82
5zcpJ-5ltmB:
8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mch CELLOBIOHYDROLASE
CHBI

(Daphnia pulex) 		PF00840
(Glyco_hydro_7) 		4 GLN A 145
PHE A 144
LEU A 237
PHE A 332
 None
 1.10A 5zcpC-5mchA:
undetectable
5zcpJ-5mchA:
undetectable		 5zcpC-5mchA:
18.61
5zcpJ-5mchA:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oen INTERFERON
REGULATORY FACTOR 9

(Mus musculus) 		no annotation 4 PHE A 339
PHE A 322
LEU A 326
PHE A 330
 None
 0.78A 5zcpC-5oenA:
undetectable
5zcpJ-5oenA:
undetectable		 5zcpC-5oenA:
undetectable
5zcpJ-5oenA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ool 39S RIBOSOMAL
PROTEIN L44,
MITOCHONDRIAL

(Homo sapiens) 		no annotation 4 GLN c 177
PHE c  92
LEU c  88
PHE c  83
 None
 1.02A 5zcpC-5oolc:
undetectable
5zcpJ-5oolc:
undetectable		 5zcpC-5oolc:
19.71
5zcpJ-5oolc:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ted LMO0488 PROTEIN

(Listeria
monocytogenes) 		no annotation 4 PHE B 287
PHE B 284
LEU B  95
PHE B  97
 None
 1.00A 5zcpC-5tedB:
undetectable
5zcpJ-5tedB:
undetectable		 5zcpC-5tedB:
20.60
5zcpJ-5tedB:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ugf PURINE NUCLEOSIDE
PHOSPHORYLASE

(Homo sapiens) 		PF01048
(PNP_UDP_1) 		4 PHE A  98
PHE A  56
LEU A  68
PHE A  70
 None
 1.09A 5zcpC-5ugfA:
undetectable
5zcpJ-5ugfA:
undetectable		 5zcpC-5ugfA:
24.48
5zcpJ-5ugfA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uz5 56 KDA U1 SMALL
NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT

(Saccharomyces
cerevisiae) 		no annotation 4 GLN G 202
PHE G 211
LEU G 215
PHE G 219
 None
 1.01A 5zcpC-5uz5G:
undetectable
5zcpJ-5uz5G:
undetectable		 5zcpC-5uz5G:
18.31
5zcpJ-5uz5G:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v0t ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)

(Paraburkholderia
xenovorans) 		PF00982
(Glyco_transf_20) 		4 PHE A 167
PHE A  98
LEU A  94
PHE A  89
 None
 0.91A 5zcpC-5v0tA:
undetectable
5zcpJ-5v0tA:
undetectable		 5zcpC-5v0tA:
20.08
5zcpJ-5v0tA:
5.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vai UNCHARACTERIZED
PROTEIN

(Oryctolagus
cuniculus) 		PF00002
(7tm_2)
PF02793
(HRM) 		4 GLN R 410
PHE R 413
PHE R 169
LEU R 172
 None
 1.00A 5zcpC-5vaiR:
2.6
5zcpJ-5vaiR:
undetectable		 5zcpC-5vaiR:
19.18
5zcpJ-5vaiR:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5voc ENVELOPE
GLYCOPROTEIN H
ENVELOPE
GLYCOPROTEIN L

(Human
betaherpesvirus
5;
Human
betaherpesvirus
5) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C)
PF01801
(Cytomega_gL) 		4 PHE A  90
PHE A  80
LEU B 183
PHE B 222
 None
 1.05A 5zcpC-5vocA:
2.6
5zcpJ-5vocA:
undetectable		 5zcpC-5vocA:
15.48
5zcpJ-5vocA:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwu LEUCINE-RICH REPEAT
AND FIBRONECTIN TYPE
III
DOMAIN-CONTAINING
PROTEIN 1

(Mus musculus) 		no annotation 4 PHE B 157
PHE B 160
LEU B 136
PHE B 109
 None
 1.04A 5zcpC-5xwuB:
undetectable
5zcpJ-5xwuB:
undetectable		 5zcpC-5xwuB:
undetectable
5zcpJ-5xwuB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c08 SODIUM-COUPLED
NEUTRAL AMINO ACID
TRANSPORTER 9

(Danio rerio) 		no annotation 4 ARG C 155
PHE C 507
LEU C 535
PHE C 531
 None
 1.10A 5zcpC-6c08C:
3.9
5zcpJ-6c08C:
undetectable		 5zcpC-6c08C:
undetectable
5zcpJ-6c08C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhm -

(-) 		no annotation 4 GLN A 139
PHE A 140
PHE A 127
LEU A 115
 None
 0.98A 5zcpC-6fhmA:
undetectable
5zcpJ-6fhmA:
undetectable		 5zcpC-6fhmA:
undetectable
5zcpJ-6fhmA:
undetectable