SIMILAR PATTERNS OF AMINO ACIDS FOR 5ZCP_C_CHDC301
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cb8 | PROTEIN(CHONDROITINASE AC) (Pedobacterheparinus) |
PF02278(Lyase_8)PF02884(Lyase_8_C)PF08124(Lyase_8_N) | 4 | HIS A 340ASP A 347TYR A 348LEU A 223 | None | 1.19A | 5zcpA-1cb8A:0.05zcpC-1cb8A:0.05zcpP-1cb8A:0.0 | 5zcpA-1cb8A:21.655zcpC-1cb8A:16.945zcpP-1cb8A:16.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h4p | GLUCAN1,3-BETA-GLUCOSIDASEI/II (Saccharomycescerevisiae) |
PF00150(Cellulase) | 4 | ASP A 246TYR A 247HIS A 328LEU A 196 | NoneNoneGOL A1449 ( 4.1A)None | 1.11A | 5zcpA-1h4pA:0.55zcpC-1h4pA:undetectable5zcpP-1h4pA:undetectable | 5zcpA-1h4pA:21.085zcpC-1h4pA:18.605zcpP-1h4pA:18.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1juh | QUERCETIN2,3-DIOXYGENASE (Aspergillusjaponicus) |
no annotation | 4 | HIS A 21THR A 124TYR A 76LEU A 251 | None | 0.88A | 5zcpA-1juhA:undetectable5zcpC-1juhA:undetectable5zcpP-1juhA:undetectable | 5zcpA-1juhA:20.455zcpC-1juhA:21.415zcpP-1juhA:21.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lur | ALDOSE 1-EPIMERASE (Caenorhabditiselegans) |
PF01263(Aldose_epim) | 4 | HIS A1163ASP A1276TYR A1285HIS A1092 | None | 0.90A | 5zcpA-1lurA:undetectable5zcpC-1lurA:undetectable5zcpP-1lurA:undetectable | 5zcpA-1lurA:21.015zcpC-1lurA:21.685zcpP-1lurA:21.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ndf | CARNITINEACETYLTRANSFERASE (Mus musculus) |
PF00755(Carn_acyltransf) | 4 | HIS A 343ASP A 466THR A 465LEU A 38 | 152 A5001 (-3.9A)None152 A5001 (-2.8A)None | 0.96A | 5zcpA-1ndfA:2.75zcpC-1ndfA:1.35zcpP-1ndfA:1.3 | 5zcpA-1ndfA:20.155zcpC-1ndfA:17.225zcpP-1ndfA:17.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nj1 | PROLINE-TRNASYNTHETASE (Methanothermobacterthermautotrophicus) |
PF00587(tRNA-synt_2b)PF03129(HGTP_anticodon)PF09180(ProRS-C_1) | 4 | HIS A 280ASP A 222THR A 223TYR A 201 | None | 1.19A | 5zcpA-1nj1A:0.05zcpC-1nj1A:undetectable5zcpP-1nj1A:undetectable | 5zcpA-1nj1A:20.075zcpC-1nj1A:18.345zcpP-1nj1A:18.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nzy | 4-CHLOROBENZOYLCOENZYME ADEHALOGENASE (Pseudomonas sp.CBS3) |
PF00378(ECH_1) | 4 | HIS B 90TRP B 89HIS B 94LEU B 181 | NoneBCA B 272 (-3.5A)NoneNone | 1.17A | 5zcpA-1nzyB:undetectable5zcpC-1nzyB:0.05zcpP-1nzyB:undetectable | 5zcpA-1nzyB:19.385zcpC-1nzyB:22.035zcpP-1nzyB:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ofm | CHONDROITINASE B (Pedobacterheparinus) |
PF14592(Chondroitinas_B) | 4 | TRP A 102THR A 168TRP A 474LEU A 484 | None | 1.05A | 5zcpA-1ofmA:undetectable5zcpC-1ofmA:undetectable5zcpP-1ofmA:undetectable | 5zcpA-1ofmA:20.005zcpC-1ofmA:17.285zcpP-1ofmA:17.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p16 | MRNA CAPPING ENZYMEALPHA SUBUNIT (Candidaalbicans) |
PF01331(mRNA_cap_enzyme)PF03919(mRNA_cap_C) | 4 | THR A 116TYR A 117HIS A 180LEU A 77 | None | 1.18A | 5zcpA-1p16A:undetectable5zcpC-1p16A:undetectable5zcpP-1p16A:undetectable | 5zcpA-1p16A:20.405zcpC-1p16A:20.605zcpP-1p16A:20.60 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1qle | CYTOCHROME C OXIDASEPOLYPEPTIDE I-BETACYTOCHROME C OXIDASEPOLYPEPTIDE III (Paracoccusdenitrificans;Paracoccusdenitrificans) |
PF00115(COX1)PF00510(COX3) | 4 | HIS A 269TRP A 323TYR A 339TRP C 106 | PC1 C 301 ( 4.2A)NonePC1 C 301 (-3.3A)PC1 C 301 (-4.4A) | 0.56A | 5zcpA-1qleA:54.55zcpC-1qleA:2.75zcpP-1qleA:2.7 | 5zcpA-1qleA:53.195zcpC-1qleA:20.595zcpP-1qleA:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r8y | GLYCINEN-METHYLTRANSFERASE (Mus musculus) |
PF13847(Methyltransf_31) | 4 | TRP A 30THR A 67TYR A 93HIS A 142 | None | 1.19A | 5zcpA-1r8yA:undetectable5zcpC-1r8yA:undetectable5zcpP-1r8yA:undetectable | 5zcpA-1r8yA:21.105zcpC-1r8yA:19.945zcpP-1r8yA:19.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uli | BIPHENYL DIOXYGENASELARGE SUBUNIT (Rhodococcusjostii) |
PF00355(Rieske)PF00848(Ring_hydroxyl_A) | 4 | ASP A 40THR A 39TYR A 38LEU A 25 | None | 0.97A | 5zcpA-1uliA:undetectable5zcpC-1uliA:undetectable5zcpP-1uliA:undetectable | 5zcpA-1uliA:20.045zcpC-1uliA:19.615zcpP-1uliA:19.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uok | OLIGO-1,6-GLUCOSIDASE (Bacillus cereus) |
PF00128(Alpha-amylase)PF16657(Malt_amylase_C) | 4 | ASP A 381TYR A 383HIS A 429LEU A 389 | None | 1.08A | 5zcpA-1uokA:undetectable5zcpC-1uokA:undetectable5zcpP-1uokA:0.0 | 5zcpA-1uokA:19.975zcpC-1uokA:17.175zcpP-1uokA:17.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vkn | N-ACETYL-GAMMA-GLUTAMYL-PHOSPHATEREDUCTASE (Thermotogamaritima) |
PF01118(Semialdhyde_dh)PF02774(Semialdhyde_dhC) | 4 | HIS A 285ASP A 327THR A 329HIS A 267 | None | 1.08A | 5zcpA-1vknA:undetectable5zcpC-1vknA:undetectable5zcpP-1vknA:undetectable | 5zcpA-1vknA:21.355zcpC-1vknA:22.715zcpP-1vknA:22.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wmr | ISOPULLULANASE (Aspergillusniger) |
PF03718(Glyco_hydro_49)PF17433(Glyco_hydro_49N) | 4 | ASP A 230THR A 227TYR A 225LEU A 207 | NAG A1002 (-3.1A)NoneNoneNone | 0.88A | 5zcpA-1wmrA:undetectable5zcpC-1wmrA:undetectable5zcpP-1wmrA:undetectable | 5zcpA-1wmrA:22.715zcpC-1wmrA:18.105zcpP-1wmrA:18.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xaj | 3-DEHYDROQUINATESYNTHASE (Staphylococcusaureus) |
PF01761(DHQ_synthase) | 4 | HIS A 242TYR A 180HIS A 246LEU A 204 | CRB A 500 ( 3.9A)NoneCRB A 500 (-4.1A)None | 1.09A | 5zcpA-1xajA:undetectable5zcpC-1xajA:undetectable5zcpP-1xajA:undetectable | 5zcpA-1xajA:22.145zcpC-1xajA:22.315zcpP-1xajA:22.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xfd | DIPEPTIDYLAMINOPEPTIDASE-LIKEPROTEIN 6 (Homo sapiens) |
PF00326(Peptidase_S9)PF00930(DPPIV_N) | 4 | ASP A 712TYR A 716TRP A 429HIS A 431 | None | 1.06A | 5zcpA-1xfdA:undetectable5zcpC-1xfdA:undetectable5zcpP-1xfdA:undetectable | 5zcpA-1xfdA:19.955zcpC-1xfdA:15.425zcpP-1xfdA:15.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yzw | GFP-LIKENON-FLUORESCENTCHROMOPROTEIN (Heteractiscrispa) |
PF01353(GFP) | 4 | THR A 19TYR A 24HIS A 106LEU A 52 | None | 1.22A | 5zcpA-1yzwA:undetectable5zcpC-1yzwA:undetectable5zcpP-1yzwA:undetectable | 5zcpA-1yzwA:17.645zcpC-1yzwA:19.425zcpP-1yzwA:19.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z7z | HUMAN COXSACKIEVIRUSA21 (Enterovirus C) |
PF00073(Rhv) | 4 | HIS 3 96ASP 3 226THR 3 227LEU 3 224 | None | 0.92A | 5zcpA-1z7z3:undetectable5zcpC-1z7z3:undetectable5zcpP-1z7z3:undetectable | 5zcpA-1z7z3:17.825zcpC-1z7z3:23.675zcpP-1z7z3:23.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zzh | CYTOCHROME CPEROXIDASE (Rhodobactercapsulatus) |
PF00034(Cytochrom_C)PF03150(CCP_MauG) | 4 | HIS A 264ASP A 243THR A 241TRP A 97 | ZN A 402 ( 3.6A)NoneNoneNone | 1.06A | 5zcpA-1zzhA:undetectable5zcpC-1zzhA:undetectable5zcpP-1zzhA:undetectable | 5zcpA-1zzhA:20.085zcpC-1zzhA:21.135zcpP-1zzhA:21.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2aam | HYPOTHETICAL PROTEINTM1410 (Thermotogamaritima) |
PF03537(Glyco_hydro_114) | 4 | TRP A 134ASP A 143TYR A 141TRP A 113 | NoneGOL A 326 (-2.6A)NoneNone | 1.19A | 5zcpA-2aamA:undetectable5zcpC-2aamA:undetectable5zcpP-2aamA:undetectable | 5zcpA-2aamA:18.465zcpC-2aamA:19.065zcpP-2aamA:19.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b2x | ANTIBODY AQC2 FABANTIBODY AQC2 FAB (Mus musculus;Mus musculus) |
PF07654(C1-set)PF07686(V-set)PF07654(C1-set)PF07686(V-set) | 4 | THR H 33TYR H 32TRP L 90LEU H 4 | None | 1.12A | 5zcpA-2b2xH:undetectable5zcpC-2b2xH:undetectable5zcpP-2b2xH:undetectable | 5zcpA-2b2xH:16.865zcpC-2b2xH:22.435zcpP-2b2xH:22.43 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2eij | CYTOCHROME C OXIDASESUBUNIT 1 (Bos taurus) |
PF00115(COX1) | 5 | HIS A 233TRP A 288ASP A 300THR A 301TYR A 304 | None | 0.00A | 5zcpA-2eijA:65.55zcpC-2eijA:2.25zcpP-2eijA:2.2 | 5zcpA-2eijA:100.005zcpC-2eijA:21.005zcpP-2eijA:21.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ggq | 401AA LONGHYPOTHETICALGLUCOSE-1-PHOSPHATETHYMIDYLYLTRANSFERASE (Sulfurisphaeratokodaii) |
PF00132(Hexapep)PF00483(NTP_transferase) | 4 | HIS A 195ASP A 172THR A 169LEU A 85 | None | 1.13A | 5zcpA-2ggqA:undetectable5zcpC-2ggqA:undetectable5zcpP-2ggqA:undetectable | 5zcpA-2ggqA:20.155zcpC-2ggqA:18.555zcpP-2ggqA:18.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gs4 | PROTEIN YCIF (Escherichiacoli) |
PF05974(DUF892) | 4 | ASP A 16THR A 17TYR A 18HIS A 47 | None | 1.19A | 5zcpA-2gs4A:2.45zcpC-2gs4A:4.05zcpP-2gs4A:3.9 | 5zcpA-2gs4A:14.175zcpC-2gs4A:20.325zcpP-2gs4A:20.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2irw | CORTICOSTEROID11-BETA-DEHYDROGENASE ISOZYME 1 (Homo sapiens) |
PF00106(adh_short) | 4 | ASP A 259THR A 265TYR A 257LEU A 215 | NoneNoneNoneNAP A 901 (-4.1A) | 1.11A | 5zcpA-2irwA:undetectable5zcpC-2irwA:undetectable5zcpP-2irwA:undetectable | 5zcpA-2irwA:18.685zcpC-2irwA:18.755zcpP-2irwA:18.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nql | ISOMERASE/LACTONIZING ENZYME (Agrobacteriumfabrum) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | TRP A 217THR A 44HIS A 292LEU A 25 | None | 1.21A | 5zcpA-2nqlA:undetectable5zcpC-2nqlA:undetectable5zcpP-2nqlA:undetectable | 5zcpA-2nqlA:22.605zcpC-2nqlA:18.355zcpP-2nqlA:18.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pmi | CYCLIN-DEPENDENTPROTEIN KINASE PHO85 (Saccharomycescerevisiae) |
PF00069(Pkinase) | 4 | ASP A 191TRP A 296HIS A 294LEU A 149 | None | 1.22A | 5zcpA-2pmiA:undetectable5zcpC-2pmiA:2.05zcpP-2pmiA:2.0 | 5zcpA-2pmiA:18.865zcpC-2pmiA:20.305zcpP-2pmiA:20.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qgq | PROTEIN TM_1862 (Thermotogamaritima) |
PF04055(Radical_SAM) | 4 | ASP A 193THR A 194TYR A 197LEU A 164 | None | 1.03A | 5zcpA-2qgqA:undetectable5zcpC-2qgqA:undetectable5zcpP-2qgqA:undetectable | 5zcpA-2qgqA:17.725zcpC-2qgqA:19.745zcpP-2qgqA:19.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vat | ACETYL-COA--DEACETYLCEPHALOSPORIN CACETYLTRANSFERASE (Acremoniumchrysogenum) |
PF00561(Abhydrolase_1) | 4 | HIS A 57ASP A 290HIS A 154LEU A 214 | None | 1.00A | 5zcpA-2vatA:undetectable5zcpC-2vatA:undetectable5zcpP-2vatA:undetectable | 5zcpA-2vatA:21.625zcpC-2vatA:20.275zcpP-2vatA:20.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vob | TRYPANOTHIONESYNTHETASE (Leishmaniamajor) |
PF03738(GSP_synth)PF05257(CHAP) | 4 | ASP A 466THR A 465TYR A 468LEU A 493 | None | 0.96A | 5zcpA-2vobA:undetectable5zcpC-2vobA:undetectable5zcpP-2vobA:undetectable | 5zcpA-2vobA:21.235zcpC-2vobA:15.175zcpP-2vobA:15.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xhg | TYROCIDINESYNTHETASE A (Brevibacillusbrevis) |
PF00668(Condensation) | 4 | HIS A 116THR A 392HIS A 36LEU A 370 | None | 1.21A | 5zcpA-2xhgA:undetectable5zcpC-2xhgA:undetectable5zcpP-2xhgA:undetectable | 5zcpA-2xhgA:20.565zcpC-2xhgA:19.865zcpP-2xhgA:19.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aw5 | MULTICOPPER OXIDASE (Pyrobaculumaerophilum) |
PF00394(Cu-oxidase)PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 4 | HIS A 461THR A 139HIS A 94LEU A 85 | C2O A 702 (-3.5A)NoneC2O A 702 ( 3.2A)None | 1.19A | 5zcpA-3aw5A:undetectable5zcpC-3aw5A:undetectable5zcpP-3aw5A:undetectable | 5zcpA-3aw5A:22.185zcpC-3aw5A:18.915zcpP-3aw5A:18.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dqp | OXIDOREDUCTASE YLBE (Lactococcuslactis) |
PF13460(NAD_binding_10) | 4 | ASP A 179THR A 180HIS A 189LEU A 16 | None | 1.06A | 5zcpA-3dqpA:undetectable5zcpC-3dqpA:undetectable5zcpP-3dqpA:undetectable | 5zcpA-3dqpA:17.955zcpC-3dqpA:20.865zcpP-3dqpA:20.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e0j | DNA POLYMERASESUBUNIT DELTA-2 (Homo sapiens) |
PF04042(DNA_pol_E_B) | 4 | HIS A 72TRP A 73ASP A 149LEU A 133 | None | 0.88A | 5zcpA-3e0jA:undetectable5zcpC-3e0jA:undetectable5zcpP-3e0jA:undetectable | 5zcpA-3e0jA:22.055zcpC-3e0jA:18.125zcpP-3e0jA:18.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ec7 | PUTATIVEDEHYDROGENASE (Salmonellaenterica) |
PF01408(GFO_IDH_MocA)PF02894(GFO_IDH_MocA_C) | 4 | HIS A 176ASP A 277TYR A 129HIS A 155 | EPE A 401 (-4.0A)NoneNoneEPE A 401 (-4.4A) | 1.08A | 5zcpA-3ec7A:undetectable5zcpC-3ec7A:undetectable5zcpP-3ec7A:undetectable | 5zcpA-3ec7A:20.735zcpC-3ec7A:19.295zcpP-3ec7A:19.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eqq | BENZENE1,2-DIOXYGENASESUBUNIT ALPHA (Pseudomonasputida) |
PF00355(Rieske)PF00848(Ring_hydroxyl_A) | 4 | ASP A 38THR A 37TYR A 36LEU A 23 | None | 0.94A | 5zcpA-3eqqA:undetectable5zcpC-3eqqA:undetectable5zcpP-3eqqA:undetectable | 5zcpA-3eqqA:21.735zcpC-3eqqA:18.975zcpP-3eqqA:18.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fhn | PROTEIN TRANSPORTPROTEIN TIP20 (Saccharomycescerevisiae) |
PF04437(RINT1_TIP1) | 4 | ASP A 654TYR A 653HIS A 643LEU A 661 | None | 1.19A | 5zcpA-3fhnA:2.65zcpC-3fhnA:3.95zcpP-3fhnA:3.9 | 5zcpA-3fhnA:20.975zcpC-3fhnA:16.625zcpP-3fhnA:16.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h74 | PYRIDOXAL KINASE (Lactobacillusplantarum) |
PF08543(Phos_pyr_kin) | 4 | TRP A 239ASP A 213THR A 214LEU A 77 | None | 1.11A | 5zcpA-3h74A:undetectable5zcpC-3h74A:undetectable5zcpP-3h74A:undetectable | 5zcpA-3h74A:21.655zcpC-3h74A:21.505zcpP-3h74A:21.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3izy | TRANSLATIONINITIATION FACTORIF-2, MITOCHONDRIAL (Bos taurus) |
PF00009(GTP_EFTU)PF11987(IF-2) | 4 | HIS P 238ASP P 198THR P 194LEU P 326 | None | 1.15A | 5zcpA-3izyP:undetectable5zcpC-3izyP:undetectable5zcpP-3izyP:undetectable | 5zcpA-3izyP:21.855zcpC-3izyP:18.225zcpP-3izyP:18.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jb9 | PRE-MRNA-SPLICINGFACTOR CWF11 (Schizosaccharomycespombe) |
PF13087(AAA_12)PF16399(Aquarius_N) | 4 | ASP X 714THR X 701TYR X 700LEU X 690 | None | 1.14A | 5zcpA-3jb9X:undetectable5zcpC-3jb9X:undetectable5zcpP-3jb9X:undetectable | 5zcpA-3jb9X:16.835zcpC-3jb9X:11.155zcpP-3jb9X:11.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jd5 | 28S RIBOSOMALPROTEIN S34,MITOCHONDRIAL (Bos taurus) |
PF00338(Ribosomal_S10) | 4 | TRP j 85TYR j 203TRP j 139HIS j 136 | NoneNoneNone U A 59 ( 3.4A) | 1.11A | 5zcpA-3jd5j:undetectable5zcpC-3jd5j:undetectable5zcpP-3jd5j:undetectable | 5zcpA-3jd5j:15.595zcpC-3jd5j:18.805zcpP-3jd5j:18.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jru | PROBABLE CYTOSOLAMINOPEPTIDASE (Xanthomonasoryzae) |
no annotation | 4 | TRP B 126ASP B 136THR B 133LEU B 159 | None | 1.16A | 5zcpA-3jruB:undetectable5zcpC-3jruB:undetectable5zcpP-3jruB:undetectable | 5zcpA-3jruB:22.305zcpC-3jruB:21.275zcpP-3jruB:21.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lv4 | GLYCOSIDE HYDROLASEYXIA (Bacilluslicheniformis) |
PF04616(Glyco_hydro_43)PF16369(GH43_C) | 4 | HIS A 365TYR A 384HIS A 350LEU A 429 | None | 1.00A | 5zcpA-3lv4A:undetectable5zcpC-3lv4A:undetectable5zcpP-3lv4A:undetectable | 5zcpA-3lv4A:22.185zcpC-3lv4A:20.655zcpP-3lv4A:20.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ml3 | OUTER MEMBRANEPROTEIN ICSAAUTOTRANSPORTER (Shigellaflexneri) |
PF03212(Pertactin) | 4 | ASP A 662THR A 634TYR A 635LEU A 648 | None | 1.09A | 5zcpA-3ml3A:undetectable5zcpC-3ml3A:undetectable5zcpP-3ml3A:undetectable | 5zcpA-3ml3A:18.965zcpC-3ml3A:21.485zcpP-3ml3A:21.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n58 | ADENOSYLHOMOCYSTEINASE (Brucellaabortus) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 4 | ASP A 115THR A 114TYR A 113HIS A 337 | NoneNoneNoneADN A 500 ( 3.6A) | 1.21A | 5zcpA-3n58A:undetectable5zcpC-3n58A:undetectable5zcpP-3n58A:undetectable | 5zcpA-3n58A:21.155zcpC-3n58A:20.405zcpP-3n58A:20.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ox4 | ALCOHOLDEHYDROGENASE 2 (Zymomonasmobilis) |
PF00465(Fe-ADH) | 4 | HIS A 198THR A 147HIS A 277LEU A 133 | FE2 A 501 (-3.3A)NoneNAD A1385 ( 3.6A)None | 1.16A | 5zcpA-3ox4A:undetectable5zcpC-3ox4A:2.45zcpP-3ox4A:2.4 | 5zcpA-3ox4A:21.525zcpC-3ox4A:20.965zcpP-3ox4A:20.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qbw | ANHYDRO-N-ACETYLMURAMIC ACID KINASE (Pseudomonasaeruginosa) |
PF03702(AnmK) | 4 | HIS A 147ASP A 316THR A 315TYR A 318 | None | 1.18A | 5zcpA-3qbwA:undetectable5zcpC-3qbwA:undetectable5zcpP-3qbwA:undetectable | 5zcpA-3qbwA:21.435zcpC-3qbwA:21.665zcpP-3qbwA:21.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qk7 | TRANSCRIPTIONALREGULATORS (Yersinia pestis) |
PF00532(Peripla_BP_1) | 4 | ASP A 7THR A 6HIS A 59LEU A 258 | None | 1.15A | 5zcpA-3qk7A:undetectable5zcpC-3qk7A:undetectable5zcpP-3qk7A:undetectable | 5zcpA-3qk7A:20.195zcpC-3qk7A:20.265zcpP-3qk7A:20.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tzg | HYPOTHETICAL PROTEINBVU_2266 (Bacteroidesvulgatus) |
no annotation | 4 | ASP A 125THR A 126HIS A 175LEU A 215 | None | 1.07A | 5zcpA-3tzgA:undetectable5zcpC-3tzgA:undetectable5zcpP-3tzgA:undetectable | 5zcpA-3tzgA:17.115zcpC-3tzgA:22.155zcpP-3tzgA:22.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ujz | METALLOPROTEASE STCE (Escherichiacoli) |
PF10462(Peptidase_M66) | 4 | HIS A 511ASP A 128THR A 129LEU A 126 | None | 1.12A | 5zcpA-3ujzA:undetectable5zcpC-3ujzA:undetectable5zcpP-3ujzA:undetectable | 5zcpA-3ujzA:19.555zcpC-3ujzA:13.395zcpP-3ujzA:13.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vsv | XYLOSIDASE (Thermoanaerobacteriumsaccharolyticum) |
PF13229(Beta_helix) | 4 | HIS A 493ASP A 401TYR A 422LEU A 377 | None | 1.14A | 5zcpA-3vsvA:undetectable5zcpC-3vsvA:undetectable5zcpP-3vsvA:undetectable | 5zcpA-3vsvA:21.225zcpC-3vsvA:16.285zcpP-3vsvA:16.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vva | ALTERNATIVE OXIDASE,MITOCHONDRIAL (Trypanosomabrucei) |
PF01786(AOX) | 4 | HIS A 206THR A 154HIS A 280LEU A 294 | None | 0.89A | 5zcpA-3vvaA:1.95zcpC-3vvaA:3.65zcpP-3vvaA:3.6 | 5zcpA-3vvaA:20.695zcpC-3vvaA:20.305zcpP-3vvaA:20.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vvl | HOMOSERINEO-ACETYLTRANSFERASE (Streptomyceslavendulae) |
PF00561(Abhydrolase_1) | 4 | ASP A 82THR A 83HIS A 58LEU A 370 | None | 0.97A | 5zcpA-3vvlA:undetectable5zcpC-3vvlA:1.65zcpP-3vvlA:1.6 | 5zcpA-3vvlA:19.385zcpC-3vvlA:20.365zcpP-3vvlA:20.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cp8 | ALLOPHANATEHYDROLASE (Pseudomonas sp.ADP) |
PF01425(Amidase) | 4 | HIS A 18ASP A 34THR A 33LEU A 68 | None | 1.20A | 5zcpA-4cp8A:undetectable5zcpC-4cp8A:undetectable5zcpP-4cp8A:undetectable | 5zcpA-4cp8A:22.675zcpC-4cp8A:19.385zcpP-4cp8A:19.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4el8 | GLYCOSIDE HYDROLASEFAMILY 48 (Caldicellulosiruptorbescii) |
PF02011(Glyco_hydro_48) | 4 | HIS A 191ASP A 223THR A 222TYR A 221 | None | 1.09A | 5zcpA-4el8A:undetectable5zcpC-4el8A:undetectable5zcpP-4el8A:undetectable | 5zcpA-4el8A:20.225zcpC-4el8A:17.875zcpP-4el8A:17.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ewf | BETA-LACTAMASE (Sphaerobacterthermophilus) |
PF13354(Beta-lactamase2) | 4 | ASP A 162THR A 160TYR A 164LEU A 166 | None | 1.16A | 5zcpA-4ewfA:undetectable5zcpC-4ewfA:undetectable5zcpP-4ewfA:undetectable | 5zcpA-4ewfA:20.125zcpC-4ewfA:21.385zcpP-4ewfA:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g0r | CAPSID PROTEIN VP1 (Rodentprotoparvovirus1) |
PF00740(Parvo_coat) | 4 | THR A 274TYR A 275HIS A 65LEU A 184 | None | 1.07A | 5zcpA-4g0rA:undetectable5zcpC-4g0rA:undetectable5zcpP-4g0rA:undetectable | 5zcpA-4g0rA:20.655zcpC-4g0rA:16.975zcpP-4g0rA:16.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ghn | UNCHARACTERIZEDPROTEIN (Bacteroidesuniformis) |
PF03572(Peptidase_S41) | 4 | HIS A 298ASP A 352THR A 353LEU A 72 | None | 1.20A | 5zcpA-4ghnA:undetectable5zcpC-4ghnA:undetectable5zcpP-4ghnA:undetectable | 5zcpA-4ghnA:21.015zcpC-4ghnA:20.615zcpP-4ghnA:20.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gkl | ALPHA-AMYLASE (Thermotoganeapolitana) |
PF00128(Alpha-amylase) | 4 | TRP A 179ASP A 212THR A 198TRP A 194 | None | 1.22A | 5zcpA-4gklA:undetectable5zcpC-4gklA:undetectable5zcpP-4gklA:undetectable | 5zcpA-4gklA:21.235zcpC-4gklA:18.875zcpP-4gklA:18.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jc0 | RIBOSOMAL PROTEINS12METHYLTHIOTRANSFERASE RIMO (Thermotogamaritima) |
PF00919(UPF0004)PF04055(Radical_SAM) | 4 | ASP A 193THR A 194TYR A 197LEU A 164 | FS5 A 501 ( 4.8A)NoneNoneNone | 1.11A | 5zcpA-4jc0A:undetectable5zcpC-4jc0A:undetectable5zcpP-4jc0A:undetectable | 5zcpA-4jc0A:19.825zcpC-4jc0A:19.735zcpP-4jc0A:19.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l3a | INTERNALIN K (Listeriamonocytogenes) |
no annotation | 4 | ASP A 105THR A 107HIS A 156LEU A 125 | None | 1.15A | 5zcpA-4l3aA:undetectable5zcpC-4l3aA:undetectable5zcpP-4l3aA:undetectable | 5zcpA-4l3aA:22.205zcpC-4l3aA:18.905zcpP-4l3aA:18.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l3f | INTERNALIN K (Listeriamonocytogenes) |
no annotation | 4 | ASP A 105THR A 107HIS A 156LEU A 125 | None | 1.18A | 5zcpA-4l3fA:undetectable5zcpC-4l3fA:undetectable5zcpP-4l3fA:undetectable | 5zcpA-4l3fA:21.785zcpC-4l3fA:22.545zcpP-4l3fA:22.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nz0 | GENOME POLYPROTEIN (Cardiovirus A) |
PF00680(RdRP_1) | 4 | HIS A 57THR A 156TYR A 154LEU A 113 | None | 1.21A | 5zcpA-4nz0A:undetectable5zcpC-4nz0A:undetectable5zcpP-4nz0A:undetectable | 5zcpA-4nz0A:22.415zcpC-4nz0A:19.915zcpP-4nz0A:19.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4onq | DNAMETHYLTRANSFERASE (Nicotianatabacum) |
PF00145(DNA_methylase) | 4 | ASP A 465THR A 466TYR A 469LEU A 348 | None | 0.86A | 5zcpA-4onqA:undetectable5zcpC-4onqA:undetectable5zcpP-4onqA:undetectable | 5zcpA-4onqA:21.075zcpC-4onqA:19.615zcpP-4onqA:19.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4orz | PROTEIN NEFSINGLE DOMAINANTIBODY SDAB19 (Humanimmunodeficiencyvirus 1;Lama glama) |
PF00469(F-protein)PF07686(V-set) | 4 | ASP C 60THR C 59TYR C 58LEU B 193 | None | 1.10A | 5zcpA-4orzC:undetectable5zcpC-4orzC:undetectable5zcpP-4orzC:undetectable | 5zcpA-4orzC:11.545zcpC-4orzC:18.395zcpP-4orzC:18.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qww | ACETYLCHOLINESTERASE (Bungarusfasciatus) |
PF00135(COesterase) | 4 | TRP A 84ASP A 131TYR A 130LEU A 143 | None | 1.16A | 5zcpA-4qwwA:undetectable5zcpC-4qwwA:undetectable5zcpP-4qwwA:undetectable | 5zcpA-4qwwA:22.475zcpC-4qwwA:18.445zcpP-4qwwA:18.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4w8b | EXO-XYLOGLUCANASE (unculturedbacterium) |
PF00150(Cellulase) | 4 | ASP A 475THR A 473HIS A 368LEU A 479 | XYS A 606 ( 4.1A)BGC A 602 ( 4.3A)NoneXYS A 618 ( 4.0A) | 1.14A | 5zcpA-4w8bA:undetectable5zcpC-4w8bA:undetectable5zcpP-4w8bA:undetectable | 5zcpA-4w8bA:19.465zcpC-4w8bA:22.145zcpP-4w8bA:22.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xlt | RESPONSE REGULATORRECEIVER PROTEIN (Dyadobacterfermentans) |
PF00072(Response_reg) | 4 | HIS A 41ASP A 51THR A 52LEU A 123 | None | 1.07A | 5zcpA-4xltA:undetectable5zcpC-4xltA:undetectable5zcpP-4xltA:undetectable | 5zcpA-4xltA:12.735zcpC-4xltA:18.295zcpP-4xltA:18.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xly | UNCHARACTERIZEDPROTEIN BLR2150 (Bradyrhizobiumdiazoefficiens) |
no annotation | 4 | ASP A 132THR A 133TYR A 136TRP A 14 | NoneNoneECP A 700 ( 4.9A)None | 1.06A | 5zcpA-4xlyA:1.95zcpC-4xlyA:undetectable5zcpP-4xlyA:undetectable | 5zcpA-4xlyA:19.805zcpC-4xlyA:19.425zcpP-4xlyA:19.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a08 | PROBABLEMANNOSYLTRANSFERASEKTR4 (Saccharomycescerevisiae) |
PF01793(Glyco_transf_15) | 4 | TRP A 451ASP A 355TYR A 286LEU A 359 | None | 1.22A | 5zcpA-5a08A:undetectable5zcpC-5a08A:undetectable5zcpP-5a08A:undetectable | 5zcpA-5a08A:20.615zcpC-5a08A:18.835zcpP-5a08A:18.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a8q | PUTATIVE RETAININGB-GLYCOSIDASE (Saccharophagusdegradans) |
PF00150(Cellulase) | 4 | TRP A 85ASP A 117TYR A 119TRP A 129 | NoneNoneNoneSO4 A1371 (-4.0A) | 1.02A | 5zcpA-5a8qA:undetectable5zcpC-5a8qA:undetectable5zcpP-5a8qA:undetectable | 5zcpA-5a8qA:22.095zcpC-5a8qA:18.735zcpP-5a8qA:18.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5az4 | FLAGELLAR HOOKSUBUNIT PROTEIN (Campylobacterjejuni) |
PF07196(Flagellin_IN)PF07559(FlaE) | 4 | HIS A 199ASP A 235THR A 502LEU A 239 | None | 1.08A | 5zcpA-5az4A:undetectable5zcpC-5az4A:undetectable5zcpP-5az4A:undetectable | 5zcpA-5az4A:21.035zcpC-5az4A:15.615zcpP-5az4A:15.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bv9 | CELLULOSE1,4-BETA-CELLOBIOSIDASE (Bacilluspumilus) |
PF02011(Glyco_hydro_48) | 4 | HIS A 12THR A 65TYR A 64LEU A 242 | None | 1.22A | 5zcpA-5bv9A:2.35zcpC-5bv9A:undetectable5zcpP-5bv9A:undetectable | 5zcpA-5bv9A:20.555zcpC-5bv9A:16.005zcpP-5bv9A:16.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5grs | STEROL REGULATORYELEMENT-BINDINGPROTEINCLEAVAGE-ACTIVATINGPROTEIN (Schizosaccharomycespombe) |
no annotation | 4 | ASP A 727THR A 720TRP A 773LEU A 674 | None | 1.12A | 5zcpA-5grsA:undetectable5zcpC-5grsA:undetectable5zcpP-5grsA:undetectable | 5zcpA-5grsA:19.815zcpC-5grsA:20.625zcpP-5grsA:20.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gsl | 778AA LONGHYPOTHETICALBETA-GALACTOSIDASE (Pyrococcushorikoshii) |
PF02449(Glyco_hydro_42) | 4 | HIS A 61THR A 54TYR A 55LEU A 382 | None | 1.16A | 5zcpA-5gslA:undetectable5zcpC-5gslA:undetectable5zcpP-5gslA:undetectable | 5zcpA-5gslA:20.365zcpC-5gslA:14.855zcpP-5gslA:14.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gx8 | EXTRACELLULARSOLUTE-BINDINGPROTEIN FAMILY 1 (Streptobacillusmoniliformis) |
PF13416(SBP_bac_8) | 4 | ASP A 282THR A 281TRP A 163LEU A 218 | None | 1.13A | 5zcpA-5gx8A:3.25zcpC-5gx8A:3.15zcpP-5gx8A:3.0 | 5zcpA-5gx8A:20.365zcpC-5gx8A:20.675zcpP-5gx8A:20.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hb4 | NUP192,NUCLEOPORINNUP192 (Chaetomiumthermophilum) |
PF11894(Nup192) | 4 | ASP B1034THR B1032TRP B 966LEU B1109 | None | 0.97A | 5zcpA-5hb4B:undetectable5zcpC-5hb4B:4.85zcpP-5hb4B:2.3 | 5zcpA-5hb4B:14.585zcpC-5hb4B:9.555zcpP-5hb4B:9.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5iki | CYTOCHROME P450(MEG) (Bacillusmegaterium) |
PF00067(p450) | 4 | TRP A 318ASP A 42THR A 43TRP A 25 | None | 1.14A | 5zcpA-5ikiA:undetectable5zcpC-5ikiA:undetectable5zcpP-5ikiA:undetectable | 5zcpA-5ikiA:21.565zcpC-5ikiA:19.575zcpP-5ikiA:19.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ikr | PROSTAGLANDIN G/HSYNTHASE 2 (Homo sapiens) |
PF00008(EGF)PF03098(An_peroxidase) | 4 | HIS A 386ASP A 213THR A 212HIS A 388 | COH A 602 (-3.7A)NoneCOH A 602 (-2.4A)COH A 602 (-3.3A) | 1.17A | 5zcpA-5ikrA:undetectable5zcpC-5ikrA:undetectable5zcpP-5ikrA:undetectable | 5zcpA-5ikrA:21.045zcpC-5ikrA:20.625zcpP-5ikrA:20.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5irm | UNCHARACTERIZEDPROTEIN (Oryctolaguscuniculus) |
PF05729(NACHT)PF13516(LRR_6) | 4 | ASP A 492THR A 491TYR A 494LEU A 462 | None | 0.94A | 5zcpA-5irmA:undetectable5zcpC-5irmA:undetectable5zcpP-5irmA:undetectable | 5zcpA-5irmA:20.455zcpC-5irmA:15.385zcpP-5irmA:15.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jxl | FLAGELLAR HOOKPROTEIN FLGE (Campylobacterjejuni) |
PF00460(Flg_bb_rod)PF06429(Flg_bbr_C)PF07196(Flagellin_IN)PF07559(FlaE) | 4 | HIS A 198ASP A 234THR A 482LEU A 238 | None | 1.11A | 5zcpA-5jxlA:4.35zcpC-5jxlA:2.35zcpP-5jxlA:2.3 | 5zcpA-5jxlA:20.425zcpC-5jxlA:15.735zcpP-5jxlA:15.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ke1 | OUTER MEMBRANEPROTEIN ICSAAUTOTRANSPORTER (Shigellaflexneri) |
PF03212(Pertactin)PF12951(PATR) | 4 | ASP A 662THR A 634TYR A 635LEU A 648 | None | 1.14A | 5zcpA-5ke1A:undetectable5zcpC-5ke1A:undetectable5zcpP-5ke1A:undetectable | 5zcpA-5ke1A:21.415zcpC-5ke1A:19.425zcpP-5ke1A:19.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n9m | COBYRIC ACIDSYNTHASE (Staphylococcusaureus) |
no annotation | 4 | ASP A 19TYR A 17HIS A 155LEU A 14 | None | 1.15A | 5zcpA-5n9mA:undetectable5zcpC-5n9mA:undetectable5zcpP-5n9mA:undetectable | 5zcpA-5n9mA:undetectable5zcpC-5n9mA:undetectable5zcpP-5n9mA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nv8 | EF-P ARGININE 32RHAMNOSYL-TRANSFERASE (Pseudomonasputida) |
PF10093(DUF2331) | 4 | TRP A 345ASP A 318TRP A 338LEU A 306 | None | 1.16A | 5zcpA-5nv8A:undetectable5zcpC-5nv8A:undetectable5zcpP-5nv8A:undetectable | 5zcpA-5nv8A:20.565zcpC-5nv8A:19.605zcpP-5nv8A:19.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nyw | PROTEASOME SUBUNIT (Yersiniabercovieri) |
no annotation | 4 | THR A 1TYR A 2HIS A 34LEU A 183 | None | 0.95A | 5zcpA-5nywA:undetectable5zcpC-5nywA:undetectable5zcpP-5nywA:undetectable | 5zcpA-5nywA:18.505zcpC-5nywA:22.765zcpP-5nywA:22.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o0l | RETICULON-4 RECEPTOR (Mus musculus) |
no annotation | 4 | ASP A 205THR A 181HIS A 136LEU A 228 | None | 1.21A | 5zcpA-5o0lA:undetectable5zcpC-5o0lA:undetectable5zcpP-5o0lA:undetectable | 5zcpA-5o0lA:20.265zcpC-5o0lA:23.015zcpP-5o0lA:23.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oh6 | INTERAPTIN (Legionellapneumophila) |
no annotation | 4 | HIS A 61ASP A 47THR A 46TRP A 65 | None | 1.15A | 5zcpA-5oh6A:undetectable5zcpC-5oh6A:2.05zcpP-5oh6A:2.0 | 5zcpA-5oh6A:16.895zcpC-5oh6A:20.005zcpP-5oh6A:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tr0 | SEED LINOLEATE13S-LIPOXYGENASE-1 (Glycine max) |
no annotation | 4 | TRP A 649ASP A 659TRP A 648HIS A 517 | None | 1.02A | 5zcpA-5tr0A:3.35zcpC-5tr0A:undetectable5zcpP-5tr0A:undetectable | 5zcpA-5tr0A:21.715zcpC-5tr0A:14.815zcpP-5tr0A:14.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u7g | CREB-BINDING PROTEIN (Mus musculus) |
PF00439(Bromodomain)PF00569(ZZ)PF06001(DUF902)PF08214(HAT_KAT11) | 4 | TRP A1473ASP A1436TYR A1434LEU A1669 | None | 1.18A | 5zcpA-5u7gA:undetectable5zcpC-5u7gA:undetectable5zcpP-5u7gA:undetectable | 5zcpA-5u7gA:19.535zcpC-5u7gA:15.995zcpP-5u7gA:15.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u7w | APYRASE (Trifoliumrepens) |
PF01150(GDA1_CD39) | 4 | HIS A 21THR A 138TYR A 141LEU A 194 | None | 0.86A | 5zcpA-5u7wA:undetectable5zcpC-5u7wA:undetectable5zcpP-5u7wA:undetectable | 5zcpA-5u7wA:23.375zcpC-5u7wA:20.605zcpP-5u7wA:20.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5urb | METHIONINE--TRNALIGASE (Acinetobacterbaumannii) |
PF08264(Anticodon_1)PF09334(tRNA-synt_1g) | 4 | ASP A 105THR A 104TYR A 107HIS A 95 | None | 1.19A | 5zcpA-5urbA:2.45zcpC-5urbA:3.45zcpP-5urbA:3.4 | 5zcpA-5urbA:21.155zcpC-5urbA:16.785zcpP-5urbA:16.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w8o | HOMOSERINEO-ACETYLTRANSFERASE (Mycolicibacteriumhassiacum) |
PF00561(Abhydrolase_1) | 4 | ASP A 91THR A 92HIS A 65LEU A 368 | None | 1.04A | 5zcpA-5w8oA:undetectable5zcpC-5w8oA:undetectable5zcpP-5w8oA:undetectable | 5zcpA-5w8oA:20.385zcpC-5w8oA:19.785zcpP-5w8oA:19.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wrj | PROTEIN-TYROSINESULFOTRANSFERASE 1 (Homo sapiens) |
PF13469(Sulfotransfer_3) | 4 | ASP A 327TRP A 249HIS A 245LEU A 321 | None | 1.00A | 5zcpA-5wrjA:undetectable5zcpC-5wrjA:undetectable5zcpP-5wrjA:undetectable | 5zcpA-5wrjA:18.385zcpC-5wrjA:21.635zcpP-5wrjA:21.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x6x | MRNA CAPPING ENZYMEP5 (Rice dwarfvirus) |
no annotation | 4 | HIS C 704THR C 630TRP C 722LEU C 779 | NoneEDO C 901 (-4.0A)NoneNone | 1.20A | 5zcpA-5x6xC:undetectable5zcpC-5x6xC:undetectable5zcpP-5x6xC:undetectable | 5zcpA-5x6xC:undetectable5zcpC-5x6xC:undetectable5zcpP-5x6xC:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y7o | UGGT (Thermomycesdupontii) |
PF06427(UDP-g_GGTase) | 4 | ASP A 418THR A 655TYR A 417LEU A 602 | None | 1.20A | 5zcpA-5y7oA:2.25zcpC-5y7oA:undetectable5zcpP-5y7oA:undetectable | 5zcpA-5y7oA:17.605zcpC-5y7oA:13.775zcpP-5y7oA:13.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y9d | ACYL-COENZYME AOXIDASE 1 (Yarrowialipolytica) |
no annotation | 4 | ASP A 519THR A 518TYR A 521HIS A 548 | None | 1.15A | 5zcpA-5y9dA:1.95zcpC-5y9dA:2.25zcpP-5y9dA:2.2 | 5zcpA-5y9dA:undetectable5zcpC-5y9dA:undetectable5zcpP-5y9dA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c29 | PUTATIVE METALRESISTANCE PROTEIN (Proteusmirabilis) |
no annotation | 4 | TRP A 46ASP A 233THR A 232HIS A 83 | None | 1.22A | 5zcpA-6c29A:undetectable5zcpC-6c29A:undetectable5zcpP-6c29A:undetectable | 5zcpA-6c29A:undetectable5zcpC-6c29A:undetectable5zcpP-6c29A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c29 | PUTATIVE METALRESISTANCE PROTEIN (Proteusmirabilis) |
no annotation | 4 | TRP A 46ASP A 233THR A 232LEU A 205 | None | 0.82A | 5zcpA-6c29A:undetectable5zcpC-6c29A:undetectable5zcpP-6c29A:undetectable | 5zcpA-6c29A:undetectable5zcpC-6c29A:undetectable5zcpP-6c29A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6d14 | TNFRECEPTOR-ASSOCIATEDPROTEIN 1 (Danio rerio) |
no annotation | 4 | HIS A 525THR A 615HIS A 521LEU A 598 | None | 1.14A | 5zcpA-6d14A:undetectable5zcpC-6d14A:undetectable5zcpP-6d14A:undetectable | 5zcpA-6d14A:undetectable5zcpC-6d14A:undetectable5zcpP-6d14A:undetectable |