SIMILAR PATTERNS OF AMINO ACIDS FOR 5ZCO_J_CHDJ101_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d02 TYPE II RESTRICTION
ENZYME MUNI

(Mycoplasma) 		PF11407
(RestrictionMunI) 		4 ILE A  86
LEU A  42
PHE A  35
LEU A 189
 None
 0.96A 5zcoA-1d02A:
undetectable
5zcoJ-1d02A:
undetectable		 5zcoA-1d02A:
17.47
5zcoJ-1d02A:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus 1) 		PF00078
(RVT_1) 		4 LEU A 109
MET A 164
THR A 165
LEU A 168
 None
 0.73A 5zcoA-1harA:
undetectable
5zcoJ-1harA:
0.1		 5zcoA-1harA:
18.00
5zcoJ-1harA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jed SULFATE
ADENYLYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 ILE A  48
LEU A  49
THR A  38
LEU A  37
 None
 0.82A 5zcoA-1jedA:
0.0
5zcoJ-1jedA:
0.0		 5zcoA-1jedA:
21.17
5zcoJ-1jedA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01063
(Aminotran_4) 		4 ILE A 332
MET A 293
THR A 292
LEU A 235
 None
 0.84A 5zcoA-1kt8A:
0.0
5zcoJ-1kt8A:
0.0		 5zcoA-1kt8A:
22.71
5zcoJ-1kt8A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lc7 L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE

(Salmonella
enterica) 		PF00155
(Aminotran_1_2) 		4 LEU A 182
ARG A 100
THR A 144
LEU A 143
 None
 0.86A 5zcoA-1lc7A:
0.0
5zcoJ-1lc7A:
0.0		 5zcoA-1lc7A:
21.47
5zcoJ-1lc7A:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mc8 FLAP ENDONUCLEASE-1

(Pyrococcus
horikoshii) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		4 ILE A   5
LEU A   8
ARG A 223
THR A 222
 None
 0.80A 5zcoA-1mc8A:
0.0
5zcoJ-1mc8A:
0.0		 5zcoA-1mc8A:
20.59
5zcoJ-1mc8A:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mv5 MULTIDRUG RESISTANCE
ABC TRANSPORTER
ATP-BINDING AND
PERMEASE PROTEIN

(Lactococcus
lactis) 		PF00005
(ABC_tran) 		4 ILE A 385
PHE A 374
ARG A 346
LEU A 343
 None
 0.96A 5zcoA-1mv5A:
0.0
5zcoJ-1mv5A:
0.0		 5zcoA-1mv5A:
19.88
5zcoJ-1mv5A:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odo PUTATIVE CYTOCHROME
P450 154A1

(Streptomyces
coelicolor) 		PF00067
(p450) 		4 PHE A 106
MET A 210
THR A 211
LEU A 214
 HEM  A1407 (-4.5A)
None
None
None
 0.90A 5zcoA-1odoA:
0.0
5zcoJ-1odoA:
0.0		 5zcoA-1odoA:
23.13
5zcoJ-1odoA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ozn RETICULON 4 RECEPTOR

(Homo sapiens) 		PF13855
(LRR_8) 		4 LEU A 112
ARG A  61
THR A  84
LEU A 107
 None
 0.80A 5zcoA-1oznA:
undetectable
5zcoJ-1oznA:
0.0		 5zcoA-1oznA:
19.64
5zcoJ-1oznA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6x ATP:SULFATE
ADENYLYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 ILE A  48
LEU A  49
THR A  38
LEU A  37
 None
 0.78A 5zcoA-1r6xA:
0.0
5zcoJ-1r6xA:
undetectable		 5zcoA-1r6xA:
21.48
5zcoJ-1r6xA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ysp TRANSCRIPTIONAL
REGULATOR KDGR

(Escherichia
coli) 		PF01614
(IclR) 		4 ILE A  35
LEU A  24
ARG A  53
LEU A  65
 None
 0.94A 5zcoA-1yspA:
undetectable
5zcoJ-1yspA:
undetectable		 5zcoA-1yspA:
15.37
5zcoJ-1yspA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2be7 ASPARTATE
CARBAMOYLTRANSFERASE
CATALYTIC CHAIN
ASPARTATE
CARBAMOYLTRANSFERASE
REGULATORY CHAIN

(Moritella
profunda;
Moritella
profunda) 		PF00185
(OTCace)
PF02729
(OTCace_N)
PF01948
(PyrI)
PF02748
(PyrI_C) 		4 ILE D 114
LEU A 115
ARG A 106
MET A 105
 None
 0.80A 5zcoA-2be7D:
undetectable
5zcoJ-2be7D:
undetectable		 5zcoA-2be7D:
17.43
5zcoJ-2be7D:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bwg GMP REDUCTASE I

(Homo sapiens) 		PF00478
(IMPDH) 		4 ILE A 154
MET A 113
THR A 114
LEU A 117
 None
 0.91A 5zcoA-2bwgA:
undetectable
5zcoJ-2bwgA:
undetectable		 5zcoA-2bwgA:
21.02
5zcoJ-2bwgA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cph RNA BINDING MOTIF
PROTEIN 19

(Mus musculus) 		PF00076
(RRM_1) 		4 ILE A 478
LEU A 481
PHE A 482
ARG A 467
 None
 0.90A 5zcoA-2cphA:
undetectable
5zcoJ-2cphA:
undetectable		 5zcoA-2cphA:
12.76
5zcoJ-2cphA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dx5 VACUOLAR PROTEIN
SORTING PROTEIN 36

(Mus musculus) 		PF11605
(Vps36_ESCRT-II) 		4 ILE A  82
LEU A 108
PHE A 110
ARG A 121
 None
 0.75A 5zcoA-2dx5A:
undetectable
5zcoJ-2dx5A:
undetectable		 5zcoA-2dx5A:
12.45
5zcoJ-2dx5A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7a TUMOR NECROSIS
FACTOR

(Homo sapiens) 		PF00229
(TNF) 		4 ILE A  80
PHE A 152
ARG A 131
LEU A 126
 None
 0.93A 5zcoA-2e7aA:
undetectable
5zcoJ-2e7aA:
undetectable		 5zcoA-2e7aA:
14.02
5zcoJ-2e7aA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g2o MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Escherichia
coli) 		PF00698
(Acyl_transf_1) 		4 LEU A  44
PHE A  33
THR A  15
LEU A  56
 None
 0.95A 5zcoA-2g2oA:
undetectable
5zcoJ-2g2oA:
undetectable		 5zcoA-2g2oA:
22.25
5zcoJ-2g2oA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ho5 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY

(Streptococcus
pneumoniae) 		PF01408
(GFO_IDH_MocA) 		4 LEU A 189
PHE A 190
THR A 244
LEU A 245
 None
 0.93A 5zcoA-2ho5A:
undetectable
5zcoJ-2ho5A:
undetectable		 5zcoA-2ho5A:
20.46
5zcoJ-2ho5A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3z C2 TOXIN COMPONENT I

(Clostridium
botulinum) 		PF03496
(ADPrib_exo_Tox) 		4 LEU A  89
ARG A  28
THR A  31
LEU A  33
 None
 0.92A 5zcoA-2j3zA:
undetectable
5zcoJ-2j3zA:
undetectable		 5zcoA-2j3zA:
19.36
5zcoJ-2j3zA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2of5 DEATH
DOMAIN-CONTAINING
PROTEIN CRADD

(Homo sapiens) 		PF00531
(Death) 		4 LEU A 180
PHE A 177
ARG A 118
MET A 197
 None
 0.95A 5zcoA-2of5A:
undetectable
5zcoJ-2of5A:
undetectable		 5zcoA-2of5A:
12.25
5zcoJ-2of5A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozg GCN5-RELATED
N-ACETYLTRANSFERASE

(Trichormus
variabilis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		4 ILE A  25
LEU A  22
ARG A  54
LEU A  99
 None
 0.89A 5zcoA-2ozgA:
undetectable
5zcoJ-2ozgA:
undetectable		 5zcoA-2ozgA:
21.72
5zcoJ-2ozgA:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0d RHO
GTPASE-ACTIVATING
PROTEIN 9

(Homo sapiens) 		PF00169
(PH) 		4 ILE A 405
LEU A 390
THR A 353
LEU A 352
 None
 0.77A 5zcoA-2p0dA:
undetectable
5zcoJ-2p0dA:
undetectable		 5zcoA-2p0dA:
12.67
5zcoJ-2p0dA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE X 252
MET X 356
THR X 357
LEU X 360
 None
 0.78A 5zcoA-2p3gX:
undetectable
5zcoJ-2p3gX:
undetectable		 5zcoA-2p3gX:
19.81
5zcoJ-2p3gX:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q7s N-FORMYLGLUTAMATE
AMIDOHYDROLASE

(Cupriavidus
pinatubonensis) 		PF05013
(FGase) 		4 ILE A 250
PHE A 192
ARG A 272
THR A 275
 None
 0.91A 5zcoA-2q7sA:
undetectable
5zcoJ-2q7sA:
undetectable		 5zcoA-2q7sA:
19.19
5zcoJ-2q7sA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qk4 TRIFUNCTIONAL PURINE
BIOSYNTHETIC PROTEIN
ADENOSINE-3

(Homo sapiens) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 ILE A 272
PHE A 203
THR A  16
LEU A  17
 None
 0.86A 5zcoA-2qk4A:
undetectable
5zcoJ-2qk4A:
undetectable		 5zcoA-2qk4A:
22.52
5zcoJ-2qk4A:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uvf EXOPOLYGALACTURONASE

(Yersinia
enterocolitica) 		PF00295
(Glyco_hydro_28)
PF12708
(Pectate_lyase_3) 		4 PHE A 347
MET A 334
THR A 335
LEU A 336
 None
 0.90A 5zcoA-2uvfA:
undetectable
5zcoJ-2uvfA:
undetectable		 5zcoA-2uvfA:
22.56
5zcoJ-2uvfA:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1

(Gracilariopsis
lemaneiformis) 		PF01055
(Glyco_hydro_31) 		4 ILE A 695
PHE A 728
THR A 757
LEU A 758
 None
 0.95A 5zcoA-2x2iA:
undetectable
5zcoJ-2x2iA:
undetectable		 5zcoA-2x2iA:
18.50
5zcoJ-2x2iA:
5.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3c TOXIC EXTRACELLULAR
ENDOPEPTIDASE

(Aeromonas
salmonicida) 		PF14521
(Aspzincin_M35) 		4 LEU A  67
PHE A  68
THR A  43
LEU A  44
 None
 0.80A 5zcoA-2x3cA:
undetectable
5zcoJ-2x3cA:
undetectable		 5zcoA-2x3cA:
20.64
5zcoJ-2x3cA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y69 CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1

(Bos taurus) 		PF02238
(COX7a) 		4 TYR J  32
MET J  36
THR J  37
LEU J  40
 None
 0.00A 5zcoA-2y69J:
undetectable
5zcoJ-2y69J:
8.0		 5zcoA-2y69J:
10.31
5zcoJ-2y69J:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yrf METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE

(Bacillus
subtilis) 		PF01008
(IF-2B) 		4 ILE A 343
LEU A 346
PHE A 347
ARG A 241
 None
 0.90A 5zcoA-2yrfA:
undetectable
5zcoJ-2yrfA:
undetectable		 5zcoA-2yrfA:
20.95
5zcoJ-2yrfA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zsg AMINOPEPTIDASE P,
PUTATIVE

(Thermotoga
maritima) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		4 ILE A 230
ARG A 151
MET A 177
LEU A 173
 None
 0.90A 5zcoA-2zsgA:
2.9
5zcoJ-2zsgA:
undetectable		 5zcoA-2zsgA:
20.79
5zcoJ-2zsgA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zsg AMINOPEPTIDASE P,
PUTATIVE

(Thermotoga
maritima) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		4 ILE A 230
ARG A 151
MET A 177
THR A 176
 None
 0.82A 5zcoA-2zsgA:
2.9
5zcoJ-2zsgA:
undetectable		 5zcoA-2zsgA:
20.79
5zcoJ-2zsgA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zts PUTATIVE
UNCHARACTERIZED
PROTEIN PH0186

(Pyrococcus
horikoshii) 		PF06745
(ATPase) 		4 ILE A 127
PHE A 123
THR A 178
LEU A 177
 None
 0.70A 5zcoA-2ztsA:
undetectable
5zcoJ-2ztsA:
undetectable		 5zcoA-2ztsA:
17.81
5zcoJ-2ztsA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b7y E3 UBIQUITIN-PROTEIN
LIGASE NEDD4

(Homo sapiens) 		PF00168
(C2) 		5 PHE A 189
ARG A 124
MET A 248
THR A 249
LEU A 213
 None
 1.38A 5zcoA-3b7yA:
undetectable
5zcoJ-3b7yA:
undetectable		 5zcoA-3b7yA:
13.39
5zcoJ-3b7yA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b7y E3 UBIQUITIN-PROTEIN
LIGASE NEDD4

(Homo sapiens) 		PF00168
(C2) 		5 PHE A 229
ARG A 124
MET A 248
THR A 249
LEU A 213
 None
 1.49A 5zcoA-3b7yA:
undetectable
5zcoJ-3b7yA:
undetectable		 5zcoA-3b7yA:
13.39
5zcoJ-3b7yA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bz6 UPF0502 PROTEIN
PSPTO_2686

(Pseudomonas
syringae group
genomosp. 3) 		PF04337
(DUF480) 		4 ILE A 172
LEU A  17
ARG A  25
LEU A  76
 None
 0.86A 5zcoA-3bz6A:
undetectable
5zcoJ-3bz6A:
undetectable		 5zcoA-3bz6A:
15.42
5zcoJ-3bz6A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c65 UVRABC SYSTEM
PROTEIN C

(Geobacillus
kaustophilus) 		PF08459
(UvrC_HhH_N) 		4 ILE A 450
PHE A 384
ARG A 433
THR A 437
 None
 0.95A 5zcoA-3c65A:
undetectable
5zcoJ-3c65A:
undetectable		 5zcoA-3c65A:
16.02
5zcoJ-3c65A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c9b VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 75

(Saccharomyces
cerevisiae) 		PF00956
(NAP) 		4 ILE A  80
LEU A  62
ARG A  73
LEU A 200
 None
 0.74A 5zcoA-3c9bA:
undetectable
5zcoJ-3c9bA:
undetectable		 5zcoA-3c9bA:
16.41
5zcoJ-3c9bA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dcp HISTIDINOL-PHOSPHATA
SE

(Listeria
monocytogenes) 		PF02811
(PHP)
PF13263
(PHP_C) 		4 LEU A  30
PHE A  32
TYR A 255
THR A 271
 None
 0.77A 5zcoA-3dcpA:
undetectable
5zcoJ-3dcpA:
undetectable		 5zcoA-3dcpA:
19.37
5zcoJ-3dcpA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ezx MONOMETHYLAMINE
CORRINOID PROTEIN 1

(Methanosarcina
barkeri) 		PF02310
(B12-binding)
PF02607
(B12-binding_2) 		4 ILE A  40
LEU A  37
ARG A 111
THR A 114
 None
 0.83A 5zcoA-3ezxA:
2.2
5zcoJ-3ezxA:
undetectable		 5zcoA-3ezxA:
18.16
5zcoJ-3ezxA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gf6 UNCHARACTERIZED
BACTERIAL
LIPOPROTEIN

(Bacteroides
thetaiotaomicron) 		PF12956
(DUF3845) 		4 LEU A 216
MET A 105
THR A 104
LEU A 103
 None
 0.94A 5zcoA-3gf6A:
undetectable
5zcoJ-3gf6A:
undetectable		 5zcoA-3gf6A:
19.49
5zcoJ-3gf6A:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gju PUTATIVE
AMINOTRANSFERASE

(Mesorhizobium
japonicum) 		PF00202
(Aminotran_3) 		4 ILE A 131
MET A 159
THR A 160
LEU A 163
 None
 0.89A 5zcoA-3gjuA:
undetectable
5zcoJ-3gjuA:
undetectable		 5zcoA-3gjuA:
22.26
5zcoJ-3gjuA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iqd OCTOPINE
DEHYDROGENASE

(Pecten maximus) 		PF02317
(Octopine_DH) 		4 LEU B 184
PHE B 194
THR B  16
LEU B  17
 None
 0.90A 5zcoA-3iqdB:
undetectable
5zcoJ-3iqdB:
undetectable		 5zcoA-3iqdB:
21.05
5zcoJ-3iqdB:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4u MAJOR CAPSID PROTEIN

(Bordetella
virus BPP1) 		no annotation 4 ILE A  38
LEU A 130
PHE A 131
LEU A 183
 None
 0.89A 5zcoA-3j4uA:
undetectable
5zcoJ-3j4uA:
undetectable		 5zcoA-3j4uA:
21.07
5zcoJ-3j4uA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfu ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B

(Thermus
thermophilus) 		PF02637
(GatB_Yqey)
PF02934
(GatB_N) 		4 ILE F 166
LEU F 163
ARG F 111
LEU F 153
 None
 0.83A 5zcoA-3kfuF:
undetectable
5zcoJ-3kfuF:
undetectable		 5zcoA-3kfuF:
18.69
5zcoJ-3kfuF:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3maj DNA PROCESSING CHAIN
A

(Rhodopseudomonas
palustris) 		PF02481
(DNA_processg_A) 		4 ILE A  41
PHE A  37
ARG A  48
LEU A  15
 None
 0.75A 5zcoA-3majA:
undetectable
5zcoJ-3majA:
undetectable		 5zcoA-3majA:
23.81
5zcoJ-3majA:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o4z TELOMERE LENGTH
REGULATION PROTEIN
TEL2

(Saccharomyces
cerevisiae) 		PF10193
(Telomere_reg-2) 		4 ILE A 225
LEU A 222
ARG A 243
LEU A 246
 None
 0.95A 5zcoA-3o4zA:
2.4
5zcoJ-3o4zA:
undetectable		 5zcoA-3o4zA:
21.65
5zcoJ-3o4zA:
6.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o66 GLYCINE
BETAINE/CARNITINE/CH
OLINE ABC
TRANSPORTER

(Staphylococcus
aureus) 		PF04069
(OpuAC) 		4 LEU A 167
PHE A 194
THR A 156
LEU A 154
 None
 0.83A 5zcoA-3o66A:
undetectable
5zcoJ-3o66A:
undetectable		 5zcoA-3o66A:
19.92
5zcoJ-3o66A:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o6o HEAT SHOCK PROTEIN
83

(Trypanosoma
brucei) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		4 ILE A 192
ARG A  64
THR A  75
LEU A  74
 None
 0.93A 5zcoA-3o6oA:
undetectable
5zcoJ-3o6oA:
undetectable		 5zcoA-3o6oA:
17.96
5zcoJ-3o6oA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3owt DNA-BINDING PROTEIN
RAP1

(Saccharomyces
cerevisiae) 		PF11626
(Rap1_C) 		4 ILE A 746
PHE A 769
THR A 756
LEU A 755
 None
 0.86A 5zcoA-3owtA:
undetectable
5zcoJ-3owtA:
undetectable		 5zcoA-3owtA:
13.87
5zcoJ-3owtA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8c NCK-ASSOCIATED
PROTEIN 1

(Homo sapiens) 		PF09735
(Nckap1) 		4 LEU B 682
ARG B 705
THR B 709
LEU B 712
 None
 0.81A 5zcoA-3p8cB:
1.4
5zcoJ-3p8cB:
undetectable		 5zcoA-3p8cB:
18.35
5zcoJ-3p8cB:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pf2 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
agalactiae) 		PF16569
(GramPos_pilinBB)
PF16570
(GramPos_pilinD3) 		4 ILE A 236
LEU A 240
THR A 270
LEU A 271
 None
 0.77A 5zcoA-3pf2A:
undetectable
5zcoJ-3pf2A:
undetectable		 5zcoA-3pf2A:
18.65
5zcoJ-3pf2A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rr1 PUTATIVE
D-GALACTONATE
DEHYDRATASE

(Ralstonia
pickettii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A  93
LEU A  90
THR A   7
LEU A   6
 None
 0.74A 5zcoA-3rr1A:
undetectable
5zcoJ-3rr1A:
undetectable		 5zcoA-3rr1A:
22.10
5zcoJ-3rr1A:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sut BETA-HEXOSAMINIDASE

(Paenibacillus
sp. TS12) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b) 		4 ILE A  40
LEU A  60
THR A  35
LEU A  34
 None
 0.94A 5zcoA-3sutA:
undetectable
5zcoJ-3sutA:
undetectable		 5zcoA-3sutA:
23.64
5zcoJ-3sutA:
8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1k POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL

(Homo sapiens) 		PF00013
(KH_1)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		4 ILE A 639
LEU A 628
ARG A 661
THR A 665
 None
 0.96A 5zcoA-3u1kA:
undetectable
5zcoJ-3u1kA:
undetectable		 5zcoA-3u1kA:
20.16
5zcoJ-3u1kA:
5.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3we7 PUTATIVE
UNCHARACTERIZED
PROTEIN PH0499

(Pyrococcus
horikoshii) 		PF02585
(PIG-L) 		4 ILE A 192
ARG A 125
THR A 129
LEU A 132
 None
 0.77A 5zcoA-3we7A:
undetectable
5zcoJ-3we7A:
undetectable		 5zcoA-3we7A:
18.46
5zcoJ-3we7A:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8c GLUCOSE-REPRESSIBLE
ALCOHOL
DEHYDROGENASE
TRANSCRIPTIONAL
EFFECTOR

(Saccharomyces
cerevisiae) 		PF03372
(Exo_endo_phos)
PF13855
(LRR_8) 		4 ILE D 376
LEU D 399
THR D 370
LEU D 392
 None
 0.84A 5zcoA-4b8cD:
undetectable
5zcoJ-4b8cD:
undetectable		 5zcoA-4b8cD:
21.05
5zcoJ-4b8cD:
6.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bob ERPP PROTEIN

(Borreliella
burgdorferi) 		PF02471
(OspE) 		4 PHE A  78
MET A  92
THR A  93
LEU A 160
 None
 0.80A 5zcoA-4bobA:
undetectable
5zcoJ-4bobA:
undetectable		 5zcoA-4bobA:
15.65
5zcoJ-4bobA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxm ERPC

(Borreliella
burgdorferi) 		PF02471
(OspE) 		4 PHE A  73
MET A  87
THR A  88
LEU A 153
 None
 0.81A 5zcoA-4bxmA:
undetectable
5zcoJ-4bxmA:
undetectable		 5zcoA-4bxmA:
15.42
5zcoJ-4bxmA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 ARG A 624
MET A 657
THR A 658
LEU A 653
 None
 0.97A 5zcoA-4feqA:
undetectable
5zcoJ-4feqA:
undetectable		 5zcoA-4feqA:
20.19
5zcoJ-4feqA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igu CG5036

(Drosophila
melanogaster) 		PF00615
(RGS) 		4 ILE A 119
LEU A 122
ARG A  36
LEU A  43
 None
 0.94A 5zcoA-4iguA:
undetectable
5zcoJ-4iguA:
undetectable		 5zcoA-4iguA:
13.31
5zcoJ-4iguA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nob POLYMERIC
IMMUNOGLOBULIN
RECEPTOR

(Mus musculus) 		PF07686
(V-set) 		4 ILE A  95
LEU A  84
ARG A  57
THR A  65
 None
None
EDO  A 204 (-4.0A)
None
 0.82A 5zcoA-4nobA:
undetectable
5zcoJ-4nobA:
undetectable		 5zcoA-4nobA:
12.43
5zcoJ-4nobA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5p UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF09994
(DUF2235) 		4 ILE A 272
LEU A 326
PHE A 325
THR A 303
 None
 0.89A 5zcoA-4o5pA:
undetectable
5zcoJ-4o5pA:
undetectable		 5zcoA-4o5pA:
19.53
5zcoJ-4o5pA:
5.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4om9 SERINE PROTEASE PET

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		4 ILE A 662
LEU A 683
THR A 674
LEU A 672
 None
 0.70A 5zcoA-4om9A:
undetectable
5zcoJ-4om9A:
undetectable		 5zcoA-4om9A:
19.71
5zcoJ-4om9A:
5.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqf PROTEIN RECA

(Mycobacterium
tuberculosis) 		PF00154
(RecA) 		4 ILE A 144
MET A 179
THR A 180
LEU A 183
 None
 0.81A 5zcoA-4oqfA:
undetectable
5zcoJ-4oqfA:
undetectable		 5zcoA-4oqfA:
20.15
5zcoJ-4oqfA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj3 INTRON-BINDING
PROTEIN AQUARIUS

(Homo sapiens) 		PF13086
(AAA_11)
PF13087
(AAA_12)
PF16399
(Aquarius_N) 		4 LEU A1119
MET A 820
THR A 819
LEU A 818
 None
 0.92A 5zcoA-4pj3A:
1.4
5zcoJ-4pj3A:
undetectable		 5zcoA-4pj3A:
15.67
5zcoJ-4pj3A:
6.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rwt LEIOMODIN-2

(Homo sapiens) 		no annotation 4 ARG C 309
MET C 312
THR C 313
LEU C 316
 None
 0.56A 5zcoA-4rwtC:
undetectable
5zcoJ-4rwtC:
undetectable		 5zcoA-4rwtC:
19.44
5zcoJ-4rwtC:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8p TALIN-1
AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING
FAMILY B MEMBER
1-INTERACTING
PROTEIN

(Mus musculus;
Mus musculus) 		no annotation
no annotation 		4 LEU B  15
PHE B  12
THR A1562
LEU A1565
 EDO  A1701 ( 4.8A)
None
None
None
 0.95A 5zcoA-4w8pB:
undetectable
5zcoJ-4w8pB:
undetectable		 5zcoA-4w8pB:
6.75
5zcoJ-4w8pB:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wuj GLYCOSIDE HYDROLASE
FAMILY 15, CELLULOSE
SIGNALING ASSOCIATED
PROTEIN ENVOY

(Trichoderma
reesei) 		PF13426
(PAS_9) 		4 ILE A  81
LEU A  78
THR A 101
LEU A 100
 None
None
FMN  A5201 (-3.4A)
None
 0.92A 5zcoA-4wujA:
undetectable
5zcoJ-4wujA:
undetectable		 5zcoA-4wujA:
16.16
5zcoJ-4wujA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wul RESPONSE REGULATOR
RECEIVER DOMAIN
PROTEIN

(Enterococcus
faecalis) 		PF00196
(GerE) 		4 ILE A 156
ARG A 148
THR A 146
LEU A 145
 None
 0.88A 5zcoA-4wulA:
undetectable
5zcoJ-4wulA:
undetectable		 5zcoA-4wulA:
8.37
5zcoJ-4wulA:
25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzh DIHYDROOROTATE
DEHYDROGENASE

(Leishmania
braziliensis) 		PF01180
(DHO_dh) 		4 ILE A 181
TYR A 169
MET A 166
LEU A 129
 None
 0.96A 5zcoA-4wzhA:
undetectable
5zcoJ-4wzhA:
undetectable		 5zcoA-4wzhA:
21.76
5zcoJ-4wzhA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xkq NICKEL ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Staphylococcus
aureus) 		PF00496
(SBP_bac_5) 		4 ILE A 259
MET A 368
THR A 367
LEU A 319
 None
 0.97A 5zcoA-4xkqA:
0.5
5zcoJ-4xkqA:
undetectable		 5zcoA-4xkqA:
20.93
5zcoJ-4xkqA:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zi6 CYTOSOL
AMINOPEPTIDASE

(Helicobacter
pylori) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		4 TYR A 166
MET A 170
THR A 171
LEU A 174
 None
 0.43A 5zcoA-4zi6A:
undetectable
5zcoJ-4zi6A:
undetectable		 5zcoA-4zi6A:
22.57
5zcoJ-4zi6A:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A

(Oryctolagus
cuniculus) 		PF01399
(PCI) 		4 ILE A 484
LEU A 491
PHE A 452
LEU A 440
 None
 0.91A 5zcoA-5a5tA:
1.9
5zcoJ-5a5tA:
undetectable		 5zcoA-5a5tA:
13.37
5zcoJ-5a5tA:
5.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bu6 BPSB (PGAB),
POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE

(Bordetella
bronchiseptica) 		PF01522
(Polysacc_deac_1) 		4 ILE A  93
ARG A 289
THR A 273
LEU A 272
 None
 0.95A 5zcoA-5bu6A:
undetectable
5zcoJ-5bu6A:
undetectable		 5zcoA-5bu6A:
18.29
5zcoJ-5bu6A:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c9e SEPL

(Escherichia
coli) 		PF07201
(HrpJ) 		4 LEU A 315
PHE A 312
THR A 290
LEU A 289
 None
 0.84A 5zcoA-5c9eA:
2.8
5zcoJ-5c9eA:
undetectable		 5zcoA-5c9eA:
19.39
5zcoJ-5c9eA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exr DNA POLYMERASE ALPHA
SUBUNIT B

(Homo sapiens) 		PF04042
(DNA_pol_E_B)
PF08418
(Pol_alpha_B_N) 		4 LEU D 377
PHE D 422
ARG D 407
LEU D 360
 None
 0.80A 5zcoA-5exrD:
undetectable
5zcoJ-5exrD:
undetectable		 5zcoA-5exrD:
21.16
5zcoJ-5exrD:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2q EF-HAND
DOMAIN-CONTAINING
PROTEIN D2

(Homo sapiens) 		PF13405
(EF-hand_6) 		4 ILE A 156
LEU A 171
MET A 121
LEU A 117
 None
 0.86A 5zcoA-5i2qA:
undetectable
5zcoJ-5i2qA:
undetectable		 5zcoA-5i2qA:
11.61
5zcoJ-5i2qA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ic8 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		no annotation 4 ARG A 127
MET A 130
THR A 131
LEU A 134
 None
 0.58A 5zcoA-5ic8A:
undetectable
5zcoJ-5ic8A:
undetectable		 5zcoA-5ic8A:
20.39
5zcoJ-5ic8A:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijb TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA

(Eptatretus
burgeri;
Mus musculus) 		PF00560
(LRR_1)
PF11921
(DUF3439)
PF13855
(LRR_8) 		4 ILE A 318
ARG A 337
THR A 357
LEU A 356
 None
 0.89A 5zcoA-5ijbA:
undetectable
5zcoJ-5ijbA:
undetectable		 5zcoA-5ijbA:
23.10
5zcoJ-5ijbA:
6.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ixg YCEI

(Burkholderia
cenocepacia) 		no annotation 4 ILE B  59
PHE B  35
ARG B 146
LEU B 107
 None
OTP  B 201 (-3.7A)
OTP  B 201 ( 4.9A)
OTP  B 201 ( 4.8A)
 0.86A 5zcoA-5ixgB:
undetectable
5zcoJ-5ixgB:
undetectable		 5zcoA-5ixgB:
15.56
5zcoJ-5ixgB:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 LEU A 928
PHE A 931
THR A 881
LEU A 884
 None
 0.79A 5zcoA-5j6sA:
undetectable
5zcoJ-5j6sA:
undetectable		 5zcoA-5j6sA:
20.29
5zcoJ-5j6sA:
5.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jw7 E3 UBIQUITIN-PROTEIN
LIGASE TRIM56

(Homo sapiens) 		PF13445
(zf-RING_UBOX) 		4 ILE B  23
LEU B  48
THR B  33
LEU B  34
 None
 0.68A 5zcoA-5jw7B:
undetectable
5zcoJ-5jw7B:
undetectable		 5zcoA-5jw7B:
10.76
5zcoJ-5jw7B:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jwf ASP/GLU-SPECIFIC
DIPEPTIDYL-PEPTIDASE

(Porphyromonas
gingivalis) 		PF10459
(Peptidase_S46) 		4 ILE A 703
LEU A 700
THR A  82
LEU A  81
 None
 0.82A 5zcoA-5jwfA:
2.0
5zcoJ-5jwfA:
undetectable		 5zcoA-5jwfA:
20.60
5zcoJ-5jwfA:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxk ASP/GLU-SPECIFIC
DIPEPTIDYL-PEPTIDASE

(Porphyromonas
endodontalis) 		PF10459
(Peptidase_S46) 		4 ILE A 700
LEU A 697
THR A  82
LEU A  81
 None
 0.81A 5zcoA-5jxkA:
2.8
5zcoJ-5jxkA:
undetectable		 5zcoA-5jxkA:
18.80
5zcoJ-5jxkA:
5.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mhf MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE

(Mus musculus) 		no annotation 4 PHE A 206
ARG A 186
THR A 168
LEU A 167
 None
 0.74A 5zcoA-5mhfA:
undetectable
5zcoJ-5mhfA:
undetectable		 5zcoA-5mhfA:
undetectable
5zcoJ-5mhfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqm GLYCOSYL HYDROLASES
FAMILY 2, SUGAR
BINDING DOMAIN

(Bacteroides
thetaiotaomicron) 		PF17132
(Glyco_hydro_106) 		4 ILE A 155
LEU A 158
THR A 370
LEU A 175
 None
 0.82A 5zcoA-5mqmA:
undetectable
5zcoJ-5mqmA:
undetectable		 5zcoA-5mqmA:
19.15
5zcoJ-5mqmA:
4.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nbq OUTER SURFACE
PROTEIN E

(Borreliella
burgdorferi) 		no annotation 4 PHE G  86
MET G 100
THR G 101
LEU G 166
 None
 0.88A 5zcoA-5nbqG:
undetectable
5zcoJ-5nbqG:
undetectable		 5zcoA-5nbqG:
undetectable
5zcoJ-5nbqG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nm7 PEPTIDOGLYCAN-BINDIN
G DOMAIN 1

(Burkholderia) 		no annotation 4 TYR G 117
ARG G 119
MET G 122
LEU G 126
 None
 0.90A 5zcoA-5nm7G:
undetectable
5zcoJ-5nm7G:
undetectable		 5zcoA-5nm7G:
undetectable
5zcoJ-5nm7G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ny0 L. REUTERIS SRRP
BINDING REGION

(Lactobacillus
reuteri) 		no annotation 4 ILE A 427
MET A 477
THR A 476
LEU A 475
 None
 0.79A 5zcoA-5ny0A:
undetectable
5zcoJ-5ny0A:
undetectable		 5zcoA-5ny0A:
undetectable
5zcoJ-5ny0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0l RETICULON-4 RECEPTOR

(Mus musculus) 		no annotation 4 LEU A 112
ARG A  61
THR A  84
LEU A 107
 None
 0.81A 5zcoA-5o0lA:
undetectable
5zcoJ-5o0lA:
undetectable		 5zcoA-5o0lA:
20.26
5zcoJ-5o0lA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oqj RNA POLYMERASE II
TRANSCRIPTION FACTOR
B SUBUNIT 1

(Saccharomyces
cerevisiae) 		no annotation 4 LEU 1  60
PHE 1  91
THR 1  28
LEU 1  27
 None
 0.66A 5zcoA-5oqj1:
undetectable
5zcoJ-5oqj1:
undetectable		 5zcoA-5oqj1:
undetectable
5zcoJ-5oqj1:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oqm GENERAL
TRANSCRIPTION AND
DNA REPAIR FACTOR
IIH SUBUNIT TFB1

(Saccharomyces
cerevisiae) 		no annotation 4 LEU 1  60
PHE 1  91
THR 1  28
LEU 1  27
 None
 0.68A 5zcoA-5oqm1:
undetectable
5zcoJ-5oqm1:
undetectable		 5zcoA-5oqm1:
undetectable
5zcoJ-5oqm1:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tpw GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2A

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		4 ILE B 127
PHE B 147
THR B 300
LEU B 299
 None
 0.85A 5zcoA-5tpwB:
undetectable
5zcoJ-5tpwB:
undetectable		 5zcoA-5tpwB:
20.58
5zcoJ-5tpwB:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vob ENVELOPE
GLYCOPROTEIN UL128

(Human
betaherpesvirus
5) 		no annotation 4 ILE C 109
LEU C 103
THR C  85
LEU C  84
 None
 0.87A 5zcoA-5vobC:
undetectable
5zcoJ-5vobC:
undetectable		 5zcoA-5vobC:
14.92
5zcoJ-5vobC:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wu3 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE

(Homo sapiens) 		PF03828
(PAP_assoc) 		4 ILE A 439
LEU A 450
THR A 457
LEU A 456
 None
 0.90A 5zcoA-5wu3A:
undetectable
5zcoJ-5wu3A:
undetectable		 5zcoA-5wu3A:
22.06
5zcoJ-5wu3A:
6.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xag TUBULIN TYROSINE
LIGASE

(Gallus gallus) 		no annotation 4 ILE F 201
LEU F 221
THR F 278
LEU F 271
 None
 0.78A 5zcoA-5xagF:
undetectable
5zcoJ-5xagF:
undetectable		 5zcoA-5xagF:
undetectable
5zcoJ-5xagF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xu1 ABC TRANSPORTER
ATP-BINDING PROTEIN

(Streptococcus
pneumoniae) 		no annotation 4 ILE A  88
LEU A 167
PHE A  90
THR A  59
 None
 0.75A 5zcoA-5xu1A:
undetectable
5zcoJ-5xu1A:
undetectable		 5zcoA-5xu1A:
undetectable
5zcoJ-5xu1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yks SNF-RELATED
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		no annotation 4 ILE A 204
LEU A 201
THR A 157
LEU A 156
 None
 0.81A 5zcoA-5yksA:
1.8
5zcoJ-5yksA:
undetectable		 5zcoA-5yksA:
19.85
5zcoJ-5yksA:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yz0 SERINE/THREONINE-PRO
TEIN KINASE ATR

(Homo sapiens) 		no annotation 4 LEU A2471
ARG A2544
MET A2543
LEU A2550
 None
 0.87A 5zcoA-5yz0A:
4.0
5zcoJ-5yz0A:
undetectable		 5zcoA-5yz0A:
undetectable
5zcoJ-5yz0A:
undetectable