SIMILAR PATTERNS OF AMINO ACIDS FOR 5ZBD_A_TRPA501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ct9 ASPARAGINE
SYNTHETASE B

(Escherichia
coli) 		PF00733
(Asn_synthase)
PF13537
(GATase_7) 		5 TYR A 191
HIS A 139
TYR A 190
ASP A 115
GLY A 119
 None
 1.46A 5zbdA-1ct9A:
0.3		 5zbdA-1ct9A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j31 HYPOTHETICAL PROTEIN
PH0642

(Pyrococcus
horikoshii) 		PF00795
(CN_hydrolase) 		5 ALA A  88
LEU A  16
TYR A  20
ASP A  45
VAL A  59
 None
 1.40A 5zbdA-1j31A:
0.0		 5zbdA-1j31A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uik ALPHA PRIME SUBUNIT
OF BETA-CONGLYCININ

(Glycine max) 		PF00190
(Cupin_1) 		5 TYR A 247
HIS A 203
LEU A 190
TYR A 209
VAL A 168
 None
 1.32A 5zbdA-1uikA:
undetectable		 5zbdA-1uikA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ytk NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE FROM
THERMOPLASMA
ACIDOPHILUM

(Thermoplasma
acidophilum) 		PF01729
(QRPTase_C) 		5 ARG A 153
ALA A  73
LEU A  61
TYR A 371
VAL A  60
 None
 1.34A 5zbdA-1ytkA:
0.5		 5zbdA-1ytkA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cvo PUTATIVE
SEMIALDEHYDE
DEHYDROGENASE

(Oryza sativa) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 ALA A 260
LEU A 304
TYR A 273
VAL A 250
GLY A 252
 None
 1.41A 5zbdA-2cvoA:
undetectable		 5zbdA-2cvoA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN

(Porphyromonas
gingivalis) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		5 TYR A 335
LEU A 173
ASP A 172
VAL A 142
GLY A 143
 TYR  A 335 ( 1.3A)
LEU  A 173 ( 0.6A)
ASP  A 172 ( 0.6A)
VAL  A 142 ( 0.6A)
GLY  A 143 ( 0.0A)
 1.47A 5zbdA-2nvvA:
0.0		 5zbdA-2nvvA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00106
(adh_short)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ALA A1393
LEU A1661
TYR A1662
VAL A1020
GLY A1402
 None
 1.26A 5zbdA-2pffA:
2.7		 5zbdA-2pffA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ab7 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0350

(Thermus
thermophilus) 		PF00582
(Usp) 		5 ARG A 179
ALA A 239
LEU A 208
VAL A 185
GLY A 184
 ARG  A 179 ( 0.6A)
ALA  A 239 ( 0.0A)
LEU  A 208 ( 0.6A)
VAL  A 185 ( 0.6A)
GLY  A 184 ( 0.0A)
 1.24A 5zbdA-3ab7A:
2.6		 5zbdA-3ab7A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5b WSPR RESPONSE
REGULATOR

(Pseudomonas
aeruginosa) 		PF00990
(GGDEF) 		5 ARG A 313
TYR A 250
ALA A 248
LEU A 205
VAL A 258
 None
 1.45A 5zbdA-3i5bA:
undetectable		 5zbdA-3i5bA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ixw HEMOCYANIN AA6 CHAIN

(Androctonus
australis) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		5 ALA A  50
LEU A 258
ASP A 260
VAL A 326
GLY A 324
 None
 1.28A 5zbdA-3ixwA:
undetectable		 5zbdA-3ixwA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kdj PROTEIN PHOSPHATASE
2C 56

(Arabidopsis
thaliana) 		PF00481
(PP2C) 		5 LEU B 320
TYR B 319
ASP B 317
VAL B 305
GLY B 307
 None
 1.40A 5zbdA-3kdjB:
undetectable		 5zbdA-3kdjB:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksr PUTATIVE SERINE
HYDROLASE

(Xanthomonas
campestris) 		PF00326
(Peptidase_S9) 		5 ALA A  47
HIS A  42
LEU A 232
VAL A 105
GLY A 106
 None
 1.07A 5zbdA-3ksrA:
undetectable		 5zbdA-3ksrA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6r PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT

(Roseobacter
denitrificans) 		PF01039
(Carboxyl_trans) 		5 ARG B 165
ALA B  66
HIS B 137
ASP B 125
GLY B 162
 None
 1.35A 5zbdA-3n6rB:
undetectable		 5zbdA-3n6rB:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ohe HISTIDINE TRIAD
(HIT) PROTEIN

(Marinobacter
hydrocarbonoclasticus) 		PF01230
(HIT) 		5 HIS A  92
LEU A   8
ASP A  11
VAL A  86
GLY A  83
 GOL  A 140 (-4.4A)
GOL  A 140 (-4.3A)
GOL  A 140 (-3.7A)
GOL  A 140 (-4.7A)
None
 1.47A 5zbdA-3oheA:
undetectable		 5zbdA-3oheA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujk PROTEIN PHOSPHATASE
2C 77

(Arabidopsis
thaliana) 		PF00481
(PP2C) 		5 LEU A 310
TYR A 309
ASP A 307
VAL A 295
GLY A 297
 None
 1.38A 5zbdA-3ujkA:
undetectable		 5zbdA-3ujkA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vre HEMOGLOBIN SUBUNIT
BETA/DELTA HYBRID

(Mammuthus
primigenius) 		PF00042
(Globin) 		5 TYR B 130
ALA B 129
LEU B  78
VAL B   1
GLY B 136
 None
 1.39A 5zbdA-3vreB:
undetectable		 5zbdA-3vreB:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5n PUTATIVE
RHAMNOSIDASE

(Streptomyces
avermitilis) 		PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		5 TYR A 329
ALA A 374
LEU A 321
VAL A 338
GLY A 339
 None
 1.40A 5zbdA-3w5nA:
undetectable		 5zbdA-3w5nA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wsy SORTILIN-RELATED
RECEPTOR

(Homo sapiens) 		PF15901
(Sortilin_C)
PF15902
(Sortilin-Vps10) 		5 ALA A 121
HIS A 608
LEU A  98
ASP A 100
GLY A 601
 None
 1.45A 5zbdA-3wsyA:
undetectable		 5zbdA-3wsyA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eh1 FLAVOHEMOPROTEIN

(Vibrio cholerae) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		5 TYR A 206
LEU A 137
TYR A 111
VAL A 145
GLY A 144
 None
None
None
None
GOL  A 306 ( 4.2A)
 1.44A 5zbdA-4eh1A:
4.3		 5zbdA-4eh1A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gaa MGC78867 PROTEIN

(Xenopus laevis) 		PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C) 		5 ALA A 287
LEU A 255
TYR A 253
VAL A 275
GLY A 266
 None
None
None
None
BES  A 702 (-4.3A)
 1.28A 5zbdA-4gaaA:
undetectable		 5zbdA-4gaaA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hbc ANTIGEN BINDING
FRAGMENT,
IMMUNOGLOBULIN IGG -
LIGHT CHAIN

(Oryctolagus
cuniculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 ALA L  81
LEU L  78
ASP L  82
VAL L 108
GLY L 110
 None
 1.47A 5zbdA-4hbcL:
1.0		 5zbdA-4hbcL:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jbe GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE

(Saccharomonospora
viridis) 		PF00171
(Aldedh) 		5 ARG A  98
ALA A  34
HIS A  95
LEU A  23
VAL A 140
 ARG  A  98 (-0.6A)
ALA  A  34 ( 0.0A)
HIS  A  95 ( 1.0A)
LEU  A  23 ( 0.5A)
VAL  A 140 ( 0.6A)
 1.28A 5zbdA-4jbeA:
1.6		 5zbdA-4jbeA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jja HYPOTHETICAL PROTEIN

(Bacteroides
fragilis) 		PF07075
(DUF1343) 		5 TYR A 246
ALA A 244
LEU A 231
VAL A 130
GLY A 131
 None
 1.37A 5zbdA-4jjaA:
undetectable		 5zbdA-4jjaA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kbr GLYCOLIPID TRANSFER
PROTEIN
DOMAIN-CONTAINING
PROTEIN 1

(Mus musculus) 		PF08718
(GLTP) 		5 ALA A 192
LEU A  10
VAL A  13
GLY A  35
TRP A  36
 None
 1.42A 5zbdA-4kbrA:
undetectable		 5zbdA-4kbrA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oic PROBABLE PROTEIN
PHOSPHATASE 2C 6

(Oryza sativa) 		PF00481
(PP2C) 		5 LEU B 359
TYR B 358
ASP B 356
VAL B 344
GLY B 346
 None
 1.33A 5zbdA-4oicB:
undetectable		 5zbdA-4oicB:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ol9 PUTATIVE
2-DEHYDROPANTOATE
2-REDUCTASE

(Mycobacterium
tuberculosis) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		5 ALA A 249
LEU A 257
ASP A 250
VAL A 188
GLY A 185
 None
None
NAP  A 301 ( 4.8A)
None
None
 1.21A 5zbdA-4ol9A:
undetectable		 5zbdA-4ol9A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p48 ANTIBODY SCFV 180

(Gallus gallus) 		PF07686
(V-set) 		5 LEU A 211
TYR A 222
ASP A 218
VAL A 192
GLY A 189
 None
 1.41A 5zbdA-4p48A:
undetectable		 5zbdA-4p48A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p4o DNA POLYMERASE BETA

(Leishmania
infantum) 		PF10391
(DNA_pol_lambd_f)
PF14716
(HHH_8)
PF14791
(DNA_pol_B_thumb)
PF14792
(DNA_pol_B_palm) 		5 ARG A 140
ALA A 109
LEU A 125
VAL A 102
GLY A 142
 None
 1.27A 5zbdA-4p4oA:
undetectable		 5zbdA-4p4oA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4raj HEME OXYGENASE

(Chlamydomonas
reinhardtii) 		PF01126
(Heme_oxygenase) 		5 ALA A 172
LEU A  54
TYR A  50
ASP A  99
GLY A 152
 None
 1.16A 5zbdA-4rajA:
undetectable		 5zbdA-4rajA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yu4 HEMOGLOBIN

(Helogale
parvula) 		PF00042
(Globin) 		5 TYR B 130
ALA B 129
LEU B  78
VAL B   1
GLY B 136
 None
 1.41A 5zbdA-4yu4B:
undetectable		 5zbdA-4yu4B:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5crl MERCURIC RESISTANCE
OPERON REGULATORY
PROTEIN

(Pseudomonas
aeruginosa) 		PF00376
(MerR)
PF09278
(MerR-DNA-bind) 		5 ARG A  25
TYR A  46
LEU A  33
ASP A  50
VAL A  54
 None
 1.22A 5zbdA-5crlA:
undetectable		 5zbdA-5crlA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hmm EXODEOXYRIBONUCLEASE

(Escherichia
virus T5) 		PF01367
(5_3_exonuc)
PF02739
(5_3_exonuc_N) 		5 ARG A 255
ALA A 248
LEU A 253
VAL A 209
GLY A 208
 None
 1.37A 5zbdA-5hmmA:
1.8		 5zbdA-5hmmA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihr PROBABLE
BETA-GALACTOSIDASE A

(Aspergillus
niger) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		5 TYR A 215
TYR A 201
ASP A 212
VAL A 208
GLY A 809
 None
 1.07A 5zbdA-5ihrA:
undetectable		 5zbdA-5ihrA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjc CYSTEINE SYNTHASE

(Brucella
abortus) 		PF00291
(PALP) 		5 ALA A 212
LEU A 206
TYR A 218
VAL A 182
GLY A 185
 None
None
None
LLP  A  42 ( 4.0A)
LLP  A  42 ( 3.4A)
 0.99A 5zbdA-5jjcA:
undetectable		 5zbdA-5jjcA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjc CYSTEINE SYNTHASE

(Brucella
abortus) 		PF00291
(PALP) 		5 ALA A 212
TYR A 218
ASP A 208
VAL A 182
GLY A 185
 None
None
None
LLP  A  42 ( 4.0A)
LLP  A  42 ( 3.4A)
 1.38A 5zbdA-5jjcA:
undetectable		 5zbdA-5jjcA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdx METALLOPEPTIDASE

(Pseudomonas
aeruginosa) 		PF13402
(Peptidase_M60) 		5 TYR A 749
ALA A 748
LEU A 871
VAL A 765
GLY A 755
 None
 1.32A 5zbdA-5kdxA:
undetectable		 5zbdA-5kdxA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpd 26S PROTEASOME
REGULATORY SUBUNIT
RPN7

(Saccharomyces
cerevisiae) 		PF01399
(PCI)
PF10602
(RPN7) 		5 LEU R 364
TYR R 338
ASP R 367
VAL R 359
GLY R 358
 None
 1.46A 5zbdA-5mpdR:
undetectable		 5zbdA-5mpdR:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ot4 INTERAPTIN

(Legionella
pneumophila) 		no annotation 5 ALA A 743
LEU A 791
ASP A 841
VAL A 787
GLY A 785
 None
 1.31A 5zbdA-5ot4A:
undetectable		 5zbdA-5ot4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6esd FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA

(Chromobacterium
violaceum) 		no annotation 10 ARG B  64
TYR B 143
ALA B 145
HIS B 163
LEU B 267
TYR B 309
ASP B 311
VAL B 363
GLY B 396
TRP B 397
 CL  B 502 ( 3.6A)
None
None
CL  B 502 ( 4.9A)
FAD  B 501 (-3.8A)
None
None
None
FAD  B 501 ( 4.3A)
FAD  B 501 (-4.9A)
 0.42A 5zbdA-6esdB:
60.3		 5zbdA-6esdB:
undetectable