SIMILAR PATTERNS OF AMINO ACIDS FOR 5Z86_J_CHDJ101_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cly IGG FAB (HUMAN IGG1,
KAPPA)


(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
4 TYR H  91
MET H  89
THR H 107
LEU H 108
None
1.43A 5z86J-1clyH:
0.0
5z86J-1clyH:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1clz IGG FAB (IGG3,
KAPPA)


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
4 TYR H  91
MET H  89
THR H 107
LEU H 108
None
1.41A 5z86J-1clzH:
0.0
5z86J-1clzH:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ej6 LAMBDA1

(Reovirus sp.)
no annotation 4 TYR B 407
MET B 406
THR B 453
LEU B 262
None
1.25A 5z86J-1ej6B:
0.0
5z86J-1ej6B:
4.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iw8 ACID PHOSPHATASE

(Shimwellia
blattae)
PF01569
(PAP2)
4 TYR A  18
MET A 102
THR A 100
LEU A  99
None
1.20A 5z86J-1iw8A:
0.0
5z86J-1iw8A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ixr RUVB

(Thermus
thermophilus)
PF05491
(RuvB_C)
PF05496
(RuvB_N)
4 ARG C 209
MET C 204
THR C 203
LEU C 173
None
ANP  C 313 (-4.4A)
None
None
1.38A 5z86J-1ixrC:
0.0
5z86J-1ixrC:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1khc DNA CYTOSINE-5
METHYLTRANSFERASE
3B2


(Mus musculus)
PF00855
(PWWP)
4 TYR A 305
ARG A 306
MET A 309
LEU A 313
None
0.89A 5z86J-1khcA:
undetectable
5z86J-1khcA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mro METHYL-COENZYME M
REDUCTASE


(Methanothermobacter
marburgensis)
PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N)
4 TYR A 338
ARG A 526
MET A 313
THR A 310
None
1.32A 5z86J-1mroA:
0.0
5z86J-1mroA:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B


(Homo sapiens)
PF00233
(PDEase_I)
4 TYR A 731
ARG A 739
THR A 743
LEU A 746
None
1.11A 5z86J-1sojA:
0.0
5z86J-1sojA:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 41 KDA
SUBUNIT


(Saccharomyces
cerevisiae)
PF00004
(AAA)
PF08542
(Rep_fac_C)
4 TYR D 134
ARG D  91
THR D  79
LEU D  78
None
1.38A 5z86J-1sxjD:
0.0
5z86J-1sxjD:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ug3 EUKARYOTIC PROTEIN
SYNTHESIS INITIATION
FACTOR 4G


(Homo sapiens)
PF02020
(W2)
PF02847
(MA3)
4 ARG A1481
MET A1484
THR A1485
LEU A1529
None
1.39A 5z86J-1ug3A:
undetectable
5z86J-1ug3A:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uyo NALP

(Neisseria
meningitidis)
PF03797
(Autotransporter)
4 TYR X 905
ARG X 907
MET X 931
LEU X 959
None
1.35A 5z86J-1uyoX:
undetectable
5z86J-1uyoX:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1whj RIKEN CDNA
1700024K14


(Mus musculus)
PF01302
(CAP_GLY)
4 ARG A  17
MET A  19
THR A  21
LEU A  23
None
1.38A 5z86J-1whjA:
undetectable
5z86J-1whjA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y4m HERV-FRD_6P24.1
PROVIRUS ANCESTRAL
ENV POLYPROTEIN


(Homo sapiens)
PF00429
(TLV_coat)
4 ARG A  72
MET A  77
THR A  79
LEU A  78
None
1.42A 5z86J-1y4mA:
undetectable
5z86J-1y4mA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bkx GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE


(Bacillus
subtilis)
PF01182
(Glucosamine_iso)
4 TYR A 116
MET A 182
THR A 181
LEU A  66
None
None
None
F6R  A1243 (-4.0A)
1.40A 5z86J-2bkxA:
undetectable
5z86J-2bkxA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c6w PENICILLIN-BINDING
PROTEIN 1A


(Streptococcus
pneumoniae)
PF00905
(Transpeptidase)
4 ARG B 619
MET B 621
THR B 623
LEU B 625
None
1.29A 5z86J-2c6wB:
undetectable
5z86J-2c6wB:
8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fbi PROBABLE
TRANSCRIPTIONAL
REGULATOR


(Pseudomonas
aeruginosa)
PF01047
(MarR)
4 ARG A  62
MET A  65
THR A  66
LEU A  69
None
0.93A 5z86J-2fbiA:
undetectable
5z86J-2fbiA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7v TLL2115 PROTEIN

(Synechococcus
elongatus)
PF13354
(Beta-lactamase2)
4 TYR A 109
ARG A  85
MET A  88
THR A  87
None
1.25A 5z86J-2j7vA:
undetectable
5z86J-2j7vA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2py6 METHYLTRANSFERASE
FKBM


(Methylobacillus
flagellatus)
PF05050
(Methyltransf_21)
4 TYR A 406
ARG A 394
THR A 213
LEU A 214
None
1.29A 5z86J-2py6A:
undetectable
5z86J-2py6A:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qor GUANYLATE KINASE

(Plasmodium
vivax)
PF00625
(Guanylate_kin)
4 ARG A 156
MET A 158
THR A 155
LEU A 154
None
1.43A 5z86J-2qorA:
undetectable
5z86J-2qorA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rdx MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
PUTATIVE


(Roseovarius
nubinhibens)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 TYR A 159
MET A 135
THR A 320
LEU A 342
None
1.43A 5z86J-2rdxA:
undetectable
5z86J-2rdxA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rkc HEMAGGLUTININ

(Measles
morbillivirus)
PF00423
(HN)
4 ARG A 355
MET A 441
THR A 455
LEU A 454
None
1.30A 5z86J-2rkcA:
undetectable
5z86J-2rkcA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rs9 PEREGRIN

(Homo sapiens)
PF00439
(Bromodomain)
4 TYR B 102
ARG B 101
MET B  93
THR B  92
None
1.37A 5z86J-2rs9B:
undetectable
5z86J-2rs9B:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x0q ALCALIGIN
BIOSYNTHESIS PROTEIN


(Bordetella
bronchiseptica)
PF04183
(IucA_IucC)
PF06276
(FhuF)
4 TYR A 511
MET A 395
THR A 394
LEU A 455
None
1.36A 5z86J-2x0qA:
undetectable
5z86J-2x0qA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x24 ACETYL-COA
CARBOXYLASE


(Bos taurus)
PF01039
(Carboxyl_trans)
4 ARG A 111
MET A 100
THR A 101
LEU A  68
None
1.43A 5z86J-2x24A:
undetectable
5z86J-2x24A:
5.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhe SYNTAXIN1

(Monosiga
brevicollis)
PF00804
(Syntaxin)
PF05739
(SNARE)
4 TYR B 154
MET B  94
THR B  93
LEU B  90
None
1.38A 5z86J-2xheB:
undetectable
5z86J-2xheB:
13.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2y69 CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1


(Bos taurus)
PF02238
(COX7a)
4 TYR J  32
ARG J  33
MET J  36
LEU J  40
None
1.18A 5z86J-2y69J:
8.0
5z86J-2y69J:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2y69 CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1


(Bos taurus)
PF02238
(COX7a)
4 TYR J  32
MET J  36
THR J  37
LEU J  40
None
0.11A 5z86J-2y69J:
8.0
5z86J-2y69J:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ziu MUS81 PROTEIN

(Danio rerio)
PF02732
(ERCC4)
4 TYR A 471
MET A 475
THR A 476
LEU A 479
None
0.82A 5z86J-2ziuA:
undetectable
5z86J-2ziuA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zsg AMINOPEPTIDASE P,
PUTATIVE


(Thermotoga
maritima)
PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
4 ARG A 151
MET A 177
THR A 176
LEU A 173
None
0.97A 5z86J-2zsgA:
undetectable
5z86J-2zsgA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1f PUTATIVE PREPHENATE
DEHYDROGENASE


(Streptococcus
mutans)
PF02153
(PDH)
4 ARG A 222
MET A 224
THR A 225
LEU A 199
None
1.29A 5z86J-3b1fA:
undetectable
5z86J-3b1fA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b7y E3 UBIQUITIN-PROTEIN
LIGASE NEDD4


(Homo sapiens)
PF00168
(C2)
4 ARG A 124
MET A 248
THR A 249
LEU A 213
None
1.30A 5z86J-3b7yA:
undetectable
5z86J-3b7yA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8l UNCHARACTERIZED
PROTEIN


(Novosphingobium
aromaticivorans)
PF13577
(SnoaL_4)
4 TYR A 112
MET A 130
THR A 129
LEU A  43
GOL  A 145 (-4.4A)
GOL  A 145 ( 3.8A)
None
None
1.27A 5z86J-3b8lA:
undetectable
5z86J-3b8lA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1


(Saccharomyces
cerevisiae)
PF00899
(ThiF)
PF09358
(E1_UFD)
PF10585
(UBA_e1_thiolCys)
PF16190
(E1_FCCH)
PF16191
(E1_4HB)
4 TYR A 959
MET A1001
THR A1000
LEU A1024
None
1.22A 5z86J-3cmmA:
undetectable
5z86J-3cmmA:
5.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e02 UNCHARACTERIZED
PROTEIN DUF849


(Paraburkholderia
xenovorans)
PF05853
(BKACE)
4 ARG A 156
MET A 158
THR A 159
LEU A 189
EDO  A 320 (-4.5A)
None
None
None
1.15A 5z86J-3e02A:
undetectable
5z86J-3e02A:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i7d SUGAR PHOSPHATE
ISOMERASE


(Ruegeria
pomeroyi)
PF07883
(Cupin_2)
4 TYR A 128
MET A 133
THR A 145
LEU A 152
CAC  A 164 (-4.3A)
None
None
None
1.40A 5z86J-3i7dA:
undetectable
5z86J-3i7dA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ig2 PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN


(Bacteroides
fragilis)
no annotation 4 TYR A 593
MET A 561
THR A 531
LEU A 530
None
1.10A 5z86J-3ig2A:
undetectable
5z86J-3ig2A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 SMALL NUCLEAR
RIBONUCLEOPROTEIN SM
D3


(Schizosaccharomyces
pombe)
PF01423
(LSM)
4 ARG D  27
MET D  18
THR D  25
LEU D  20
None
1.17A 5z86J-3jb9D:
undetectable
5z86J-3jb9D:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k13 5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE


(Bacteroides
thetaiotaomicron)
PF00809
(Pterin_bind)
4 ARG A 407
MET A 410
THR A 411
LEU A 414
None
0.74A 5z86J-3k13A:
undetectable
5z86J-3k13A:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nab FAB15 MUT6 HEAVY
CHAIN


(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
4 TYR H  91
MET H  89
THR H 107
LEU H 108
None
1.33A 5z86J-3nabH:
undetectable
5z86J-3nabH:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntk MATERNAL PROTEIN
TUDOR


(Drosophila
melanogaster)
PF00567
(TUDOR)
4 TYR A2452
MET A2376
THR A2377
LEU A2380
None
1.20A 5z86J-3ntkA:
undetectable
5z86J-3ntkA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4


(Saccharomyces
cerevisiae)
PF11701
(UNC45-central)
4 ARG A 340
MET A 379
THR A 378
LEU A 376
None
1.43A 5z86J-3opbA:
undetectable
5z86J-3opbA:
5.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3se7 VANA

(-)
PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C)
4 TYR A 315
MET A 319
THR A 320
LEU A 324
None
0.94A 5z86J-3se7A:
undetectable
5z86J-3se7A:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ue3 SEPTUM FORMATION,
PENICILLIN BINDING
PROTEIN 3,
PEPTIDOGLYCAN
SYNTHETASE


(Acinetobacter
sp. ATCC 27244)
PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
4 ARG A 373
MET A 365
THR A 371
LEU A 367
None
1.09A 5z86J-3ue3A:
undetectable
5z86J-3ue3A:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uji FAB REGION OF THE
HEAVY CHAIN OF
ANTI-HIV-1 V3
MONOCLONAL ANTIBODY
2558


(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
4 TYR H  91
MET H  89
THR H 107
LEU H 108
None
1.43A 5z86J-3ujiH:
undetectable
5z86J-3ujiH:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3utk LIPOPROTEIN OUTS

(Dickeya
dadantii)
PF09691
(T2SS_PulS_OutS)
4 ARG A 120
MET A 122
THR A 123
LEU A 126
None
1.20A 5z86J-3utkA:
undetectable
5z86J-3utkA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zxs CRYPTOCHROME B

(Rhodobacter
sphaeroides)
PF04244
(DPRP)
4 TYR A 439
ARG A 343
MET A 344
LEU A 347
None
None
SF4  A1510 (-4.5A)
None
1.15A 5z86J-3zxsA:
undetectable
5z86J-3zxsA:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a1g MITOTIC CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1


(Homo sapiens)
PF08311
(Mad3_BUB1_I)
4 TYR A 140
ARG A 141
THR A 145
LEU A 147
None
1.18A 5z86J-4a1gA:
undetectable
5z86J-4a1gA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4asi ACETYL-COA
CARBOXYLASE 1


(Homo sapiens)
PF01039
(Carboxyl_trans)
4 ARG A1712
MET A1701
THR A1702
LEU A1669
None
1.42A 5z86J-4asiA:
undetectable
5z86J-4asiA:
6.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3


(Mus musculus)
PF07714
(Pkinase_Tyr)
4 ARG A 624
MET A 657
THR A 658
LEU A 653
None
0.99A 5z86J-4feqA:
undetectable
5z86J-4feqA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl2 INTERFERON-INDUCED
HELICASE C
DOMAIN-CONTAINING
PROTEIN 1


(Homo sapiens)
PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD)
4 ARG A 560
MET A 558
THR A 559
LEU A 555
None
1.39A 5z86J-4gl2A:
undetectable
5z86J-4gl2A:
7.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h3t CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY


(Acidimicrobium
ferrooxidans)
PF09481
(CRISPR_Cse1)
4 TYR A 464
ARG A 465
THR A 469
LEU A 471
None
1.43A 5z86J-4h3tA:
undetectable
5z86J-4h3tA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwe FAB HEAVY CHAIN

(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
4 TYR H  96
MET H  94
THR H 113
LEU H 114
None
1.37A 5z86J-4hweH:
undetectable
5z86J-4hweH:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ina SACCHAROPINE
DEHYDROGENASE


(Wolinella
succinogenes)
PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C)
4 TYR A 103
MET A  93
THR A  91
LEU A  90
None
1.16A 5z86J-4inaA:
undetectable
5z86J-4inaA:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k0u LIPOPROTEIN OUTS

(Dickeya
dadantii)
PF09691
(T2SS_PulS_OutS)
4 ARG A 120
MET A 122
THR A 123
LEU A 126
None
0.99A 5z86J-4k0uA:
undetectable
5z86J-4k0uA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3b OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA


(Neisseria
gonorrhoeae)
PF01103
(Bac_surface_Ag)
PF07244
(POTRA)
4 TYR A 296
MET A 301
THR A 302
LEU A 305
None
0.98A 5z86J-4k3bA:
undetectable
5z86J-4k3bA:
5.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kmr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY


(Sanguibacter
keddieii)
PF13377
(Peripla_BP_3)
4 TYR A 208
ARG A 209
THR A 213
LEU A 217
None
1.23A 5z86J-4kmrA:
undetectable
5z86J-4kmrA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ksd R2 PROTEIN

(Lama glama)
PF07686
(V-set)
4 ARG B  19
MET B  83
THR B  84
LEU B  86
None
1.42A 5z86J-4ksdB:
undetectable
5z86J-4ksdB:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN


(Rhodopirellula
baltica)
PF13458
(Peripla_BP_6)
4 TYR A 319
ARG A 320
MET A 323
LEU A 330
None
1.09A 5z86J-4kv7A:
undetectable
5z86J-4kv7A:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kxb GLUTAMYL
AMINOPEPTIDASE


(Homo sapiens)
PF01433
(Peptidase_M1)
PF11838
(ERAP1_C)
4 ARG A 143
MET A 190
THR A 189
LEU A 188
None
0.87A 5z86J-4kxbA:
undetectable
5z86J-4kxbA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ljs PERIPLASMIC BINDING
PROTEIN


(Veillonella
parvula)
PF01497
(Peripla_BP_2)
4 TYR A  99
ARG A 314
THR A  73
LEU A  77
None
1.33A 5z86J-4ljsA:
undetectable
5z86J-4ljsA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ly4 PEPTIDOGLYCAN
DEACETYLASE


(Helicobacter
pylori)
PF01522
(Polysacc_deac_1)
4 TYR A   9
MET A 244
THR A 245
LEU A 198
None
1.24A 5z86J-4ly4A:
undetectable
5z86J-4ly4A:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n2x DL-2-HALOACID
DEHALOGENASE


(Methylobacterium
sp. CPA1)
PF10778
(DehI)
4 ARG A 249
MET A 251
THR A 252
LEU A 255
None
0.88A 5z86J-4n2xA:
undetectable
5z86J-4n2xA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzu 13PL LIGHT CHAIN

(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
4 ARG H  19
MET H  82
THR H  17
LEU H  82
None
1.28A 5z86J-4nzuH:
undetectable
5z86J-4nzuH:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4obs ALPHA-L-IDURONIDASE

(Homo sapiens)
PF01229
(Glyco_hydro_39)
4 TYR A 318
ARG A 313
THR A 364
LEU A 365
None
CL  A 915 (-4.0A)
None
None
1.41A 5z86J-4obsA:
undetectable
5z86J-4obsA:
6.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi4 CELLOBIOSE
DEHYDROGENASE


(Crassicarpon
hotsonii)
PF00732
(GMC_oxred_N)
PF00734
(CBM_1)
PF05199
(GMC_oxred_C)
4 TYR A 728
ARG A 726
THR A 725
LEU A 708
None
1.42A 5z86J-4qi4A:
undetectable
5z86J-4qi4A:
8.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rae HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE


(Mycobacterium
tuberculosis)
PF00155
(Aminotran_1_2)
4 ARG A 228
MET A 230
THR A 229
LEU A 241
None
1.16A 5z86J-4raeA:
undetectable
5z86J-4raeA:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rm7 ACYL-COA
DEHYDROGENASE


(Slackia
heliotrinireducens)
PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
4 TYR A 322
MET A 295
THR A 293
LEU A 292
None
1.20A 5z86J-4rm7A:
undetectable
5z86J-4rm7A:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rwt LEIOMODIN-2

(Homo sapiens)
no annotation 4 ARG C 309
MET C 312
THR C 313
LEU C 316
None
0.56A 5z86J-4rwtC:
undetectable
5z86J-4rwtC:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upk PHOSPHONATE
MONOESTER HYDROLASE


(Ruegeria
pomeroyi)
PF00884
(Sulfatase)
4 TYR A 257
MET A 332
THR A 333
LEU A 406
None
1.24A 5z86J-4upkA:
undetectable
5z86J-4upkA:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wuu IMMUNOGLOBULIN HEAVY
CHAIN


(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
4 TYR E  95
MET E  93
THR E 115
LEU E 116
None
1.41A 5z86J-4wuuE:
undetectable
5z86J-4wuuE:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zi6 CYTOSOL
AMINOPEPTIDASE


(Helicobacter
pylori)
PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N)
4 TYR A 166
MET A 170
THR A 171
LEU A 174
None
0.40A 5z86J-4zi6A:
undetectable
5z86J-4zi6A:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zvi DNA GYRASE SUBUNIT B

(Escherichia
coli)
PF00204
(DNA_gyraseB)
PF02518
(HATPase_c)
4 ARG A 286
MET A 289
THR A 290
LEU A 293
None
0.95A 5z86J-4zviA:
undetectable
5z86J-4zviA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a22 VESICULAR STOMATITIS
VIRUS L POLYMERASE


(Vesicular
stomatitis
virus)
PF00946
(Mononeg_RNA_pol)
PF14314
(Methyltrans_Mon)
PF14318
(Mononeg_mRNAcap)
4 ARG A1215
MET A1198
THR A1199
LEU A1201
None
1.43A 5z86J-5a22A:
undetectable
5z86J-5a22A:
2.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a96 POLYHEDRIN

(Cypovirus 14)
PF17515
(CPV_Polyhedrin)
4 ARG A 168
MET A 173
THR A 172
LEU A  61
GTP  A1250 (-4.3A)
None
None
None
1.26A 5z86J-5a96A:
undetectable
5z86J-5a96A:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aov GLYOXYLATE REDUCTASE

(Pyrococcus
furiosus)
PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
4 TYR A 220
MET A 219
THR A 218
LEU A 214
EDO  A1351 (-3.4A)
1PE  A1349 (-4.2A)
NAP  A1335 (-4.2A)
1PE  A1345 (-4.5A)
1.35A 5z86J-5aovA:
undetectable
5z86J-5aovA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b0n E3 UBIQUITIN-PROTEIN
LIGASE IPAH9.8


(Shigella
flexneri)
PF12468
(TTSSLRR)
4 ARG A 163
MET A 142
THR A 141
LEU A 122
None
1.13A 5z86J-5b0nA:
undetectable
5z86J-5b0nA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by7 3-OXOACYL-ACP
SYNTHASE III


(Verrucosispora
maris)
PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III)
4 ARG A 254
MET A 255
THR A 256
LEU A 251
None
1.38A 5z86J-5by7A:
undetectable
5z86J-5by7A:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dum 65C6 HEAVY CHAIN

(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
4 TYR H  95
MET H  93
THR H 121
LEU H 122
None
1.40A 5z86J-5dumH:
undetectable
5z86J-5dumH:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE


(Plasmodium
vivax)
PF00027
(cNMP_binding)
PF00069
(Pkinase)
4 ARG A 276
MET A 279
THR A 280
LEU A 283
None
0.85A 5z86J-5ezrA:
undetectable
5z86J-5ezrA:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f96 HEAVY CHAIN OF
ANTIBODY CH235.12


(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
4 ARG H  82
MET H  18
THR H  19
LEU H  20
None
1.40A 5z86J-5f96H:
undetectable
5z86J-5f96H:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fdn PHOSPHOENOLPYRUVATE
CARBOXYLASE 3


(Arabidopsis
thaliana)
PF00311
(PEPcase)
4 ARG A 666
MET A 634
THR A 633
LEU A 632
None
1.09A 5z86J-5fdnA:
undetectable
5z86J-5fdnA:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g56 CARBOHYDRATE BINDING
FAMILY 6


(Ruminiclostridium
thermocellum)
PF00150
(Cellulase)
PF03422
(CBM_6)
4 TYR A  75
ARG A 121
THR A 122
LEU A 127
None
1.29A 5z86J-5g56A:
undetectable
5z86J-5g56A:
4.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gnc AVH146

(Phytophthora
sojae)
no annotation 4 TYR A 232
MET A 228
THR A 227
LEU A 224
None
0.94A 5z86J-5gncA:
undetectable
5z86J-5gncA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ic8 PUTATIVE
UNCHARACTERIZED
PROTEIN


(Chaetomium
thermophilum)
no annotation 4 ARG A 127
MET A 130
THR A 131
LEU A 134
None
0.56A 5z86J-5ic8A:
undetectable
5z86J-5ic8A:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iig VACUOLAR TRANSPORTER
CHAPERONE 4


(Saccharomyces
cerevisiae)
PF03105
(SPX)
PF09359
(VTC)
4 ARG A 356
MET A 382
THR A 381
LEU A 380
None
0.96A 5z86J-5iigA:
undetectable
5z86J-5iigA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1


(Homo sapiens)
PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
4 ARG A1408
MET A1405
THR A1404
LEU A1401
None
1.30A 5z86J-5iy9A:
undetectable
5z86J-5iy9A:
2.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m32 26S PROTEASE
REGULATORY SUBUNIT 4


(Homo sapiens)
PF00227
(Proteasome)
PF10584
(Proteasome_A_N)
4 ARG d 307
MET d 309
THR d 308
LEU d 312
None
1.39A 5z86J-5m32d:
undetectable
5z86J-5m32d:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nm7 PEPTIDOGLYCAN-BINDIN
G DOMAIN 1


(Burkholderia)
no annotation 4 TYR G 117
ARG G 119
MET G 122
LEU G 126
None
0.91A 5z86J-5nm7G:
undetectable
5z86J-5nm7G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nqd ARSENITE OXIDASE
LARGE SUBUNIT AIOA
[3FE-4S] CLUSTER,
MO-MOLYBDOPTERIN
COFACTOR-BINDING
ACTIVE SITE


(Rhizobium sp.
NT-26)
no annotation 4 ARG A 149
MET A 604
THR A 603
LEU A 600
None
1.16A 5z86J-5nqdA:
undetectable
5z86J-5nqdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o3w PEPTIDE CYCLASE 1

(Gypsophila
vaccaria)
no annotation 4 TYR A 642
MET A 668
THR A 667
LEU A 664
None
1.34A 5z86J-5o3wA:
undetectable
5z86J-5o3wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o6v FAB 19/1786 - HEAVY
CHAIN


(Mus musculus)
no annotation 4 TYR H  95
MET H  93
THR H 114
LEU H 115
None
1.42A 5z86J-5o6vH:
undetectable
5z86J-5o6vH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t1v NS2B-NS3
PROTEASE,NS2B-NS3
PROTEASE


(Zika virus)
PF00949
(Peptidase_S7)
PF01002
(Flavi_NS2B)
4 TYR A   9
ARG A  93
MET A  91
THR A  99
None
1.32A 5z86J-5t1vA:
undetectable
5z86J-5t1vA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tro PENICILLIN-BINDING
PROTEIN 1


(Staphylococcus
aureus)
PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
4 ARG A 341
MET A 373
THR A 371
LEU A 372
None
1.42A 5z86J-5troA:
undetectable
5z86J-5troA:
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u0u DH270.1 SINGLE-CHAIN
VARIABLE FRAGMENT


(Homo sapiens)
no annotation 4 TYR G  95
MET G  93
THR G 121
LEU G 122
None
1.32A 5z86J-5u0uG:
undetectable
5z86J-5u0uG:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uc2 DOMAIN OF UNKNOWN
FUNCTION DUF1849


(Brucella
abortus)
PF08904
(DUF1849)
4 TYR A 235
MET A 252
THR A 251
LEU A 250
None
1.27A 5z86J-5uc2A:
undetectable
5z86J-5uc2A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v6b PDZ
DOMAIN-CONTAINING
PROTEIN GIPC1


(Mus musculus)
PF00595
(PDZ)
4 ARG A 307
MET A 287
THR A 286
LEU A 283
None
1.32A 5z86J-5v6bA:
undetectable
5z86J-5v6bA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vfz GP33

(Mycobacterium
virus Brujita)
no annotation 4 ARG A 169
MET A 171
THR A 170
LEU A 183
None
1.36A 5z86J-5vfzA:
undetectable
5z86J-5vfzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vqh TUDOR AND KH
DOMAIN-CONTAINING
PROTEIN HOMOLOG


(Bombyx mori)
PF00567
(TUDOR)
4 TYR A  39
ARG A  45
THR A  49
LEU A  50
None
1.27A 5z86J-5vqhA:
undetectable
5z86J-5vqhA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vxz GROWTH
ARREST-SPECIFIC
PROTEIN 6


(Homo sapiens)
PF00054
(Laminin_G_1)
PF02210
(Laminin_G_2)
4 TYR A 480
MET A 644
THR A 645
LEU A 646
None
1.36A 5z86J-5vxzA:
undetectable
5z86J-5vxzA:
8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xk8 UNDECAPRENYL
DIPHOSPHATE SYNTHASE


(Streptomyces
sp. CNH189)
no annotation 4 TYR A  26
MET A  29
THR A  30
LEU A  33
None
1.04A 5z86J-5xk8A:
undetectable
5z86J-5xk8A:
undetectable