SIMILAR PATTERNS OF AMINO ACIDS FOR 5Z86_J_CHDJ101
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cly | IGG FAB (HUMAN IGG1,KAPPA) (Homo sapiens) |
PF07654(C1-set)PF07686(V-set) | 4 | TYR H 91MET H 89THR H 107LEU H 108 | None | 1.43A | 5z86J-1clyH:0.0 | 5z86J-1clyH:16.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1clz | IGG FAB (IGG3,KAPPA) (Mus musculus) |
PF07654(C1-set)PF07686(V-set) | 4 | TYR H 91MET H 89THR H 107LEU H 108 | None | 1.41A | 5z86J-1clzH:0.0 | 5z86J-1clzH:15.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ej6 | LAMBDA1 (Reovirus sp.) |
no annotation | 4 | TYR B 407MET B 406THR B 453LEU B 262 | None | 1.25A | 5z86J-1ej6B:0.0 | 5z86J-1ej6B:4.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1iw8 | ACID PHOSPHATASE (Shimwelliablattae) |
PF01569(PAP2) | 4 | TYR A 18MET A 102THR A 100LEU A 99 | None | 1.20A | 5z86J-1iw8A:0.0 | 5z86J-1iw8A:17.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ixr | RUVB (Thermusthermophilus) |
PF05491(RuvB_C)PF05496(RuvB_N) | 4 | ARG C 209MET C 204THR C 203LEU C 173 | NoneANP C 313 (-4.4A)NoneNone | 1.38A | 5z86J-1ixrC:0.0 | 5z86J-1ixrC:12.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1khc | DNA CYTOSINE-5METHYLTRANSFERASE3B2 (Mus musculus) |
PF00855(PWWP) | 4 | TYR A 305ARG A 306MET A 309LEU A 313 | None | 0.89A | 5z86J-1khcA:undetectable | 5z86J-1khcA:21.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mro | METHYL-COENZYME MREDUCTASE (Methanothermobactermarburgensis) |
PF02249(MCR_alpha)PF02745(MCR_alpha_N) | 4 | TYR A 338ARG A 526MET A 313THR A 310 | None | 1.32A | 5z86J-1mroA:0.0 | 5z86J-1mroA:8.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1soj | CGMP-INHIBITED3',5'-CYCLICPHOSPHODIESTERASE B (Homo sapiens) |
PF00233(PDEase_I) | 4 | TYR A 731ARG A 739THR A 743LEU A 746 | None | 1.11A | 5z86J-1sojA:0.0 | 5z86J-1sojA:9.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sxj | ACTIVATOR 1 41 KDASUBUNIT (Saccharomycescerevisiae) |
PF00004(AAA)PF08542(Rep_fac_C) | 4 | TYR D 134ARG D 91THR D 79LEU D 78 | None | 1.38A | 5z86J-1sxjD:0.0 | 5z86J-1sxjD:11.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ug3 | EUKARYOTIC PROTEINSYNTHESIS INITIATIONFACTOR 4G (Homo sapiens) |
PF02020(W2)PF02847(MA3) | 4 | ARG A1481MET A1484THR A1485LEU A1529 | None | 1.39A | 5z86J-1ug3A:undetectable | 5z86J-1ug3A:9.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uyo | NALP (Neisseriameningitidis) |
PF03797(Autotransporter) | 4 | TYR X 905ARG X 907MET X 931LEU X 959 | None | 1.35A | 5z86J-1uyoX:undetectable | 5z86J-1uyoX:11.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1whj | RIKEN CDNA1700024K14 (Mus musculus) |
PF01302(CAP_GLY) | 4 | ARG A 17MET A 19THR A 21LEU A 23 | None | 1.38A | 5z86J-1whjA:undetectable | 5z86J-1whjA:15.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y4m | HERV-FRD_6P24.1PROVIRUS ANCESTRALENV POLYPROTEIN (Homo sapiens) |
PF00429(TLV_coat) | 4 | ARG A 72MET A 77THR A 79LEU A 78 | None | 1.42A | 5z86J-1y4mA:undetectable | 5z86J-1y4mA:22.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bkx | GLUCOSAMINE-6-PHOSPHATE DEAMINASE (Bacillussubtilis) |
PF01182(Glucosamine_iso) | 4 | TYR A 116MET A 182THR A 181LEU A 66 | NoneNoneNoneF6R A1243 (-4.0A) | 1.40A | 5z86J-2bkxA:undetectable | 5z86J-2bkxA:10.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c6w | PENICILLIN-BINDINGPROTEIN 1A (Streptococcuspneumoniae) |
PF00905(Transpeptidase) | 4 | ARG B 619MET B 621THR B 623LEU B 625 | None | 1.29A | 5z86J-2c6wB:undetectable | 5z86J-2c6wB:8.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fbi | PROBABLETRANSCRIPTIONALREGULATOR (Pseudomonasaeruginosa) |
PF01047(MarR) | 4 | ARG A 62MET A 65THR A 66LEU A 69 | None | 0.93A | 5z86J-2fbiA:undetectable | 5z86J-2fbiA:14.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j7v | TLL2115 PROTEIN (Synechococcuselongatus) |
PF13354(Beta-lactamase2) | 4 | TYR A 109ARG A 85MET A 88THR A 87 | None | 1.25A | 5z86J-2j7vA:undetectable | 5z86J-2j7vA:12.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2py6 | METHYLTRANSFERASEFKBM (Methylobacillusflagellatus) |
PF05050(Methyltransf_21) | 4 | TYR A 406ARG A 394THR A 213LEU A 214 | None | 1.29A | 5z86J-2py6A:undetectable | 5z86J-2py6A:10.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qor | GUANYLATE KINASE (Plasmodiumvivax) |
PF00625(Guanylate_kin) | 4 | ARG A 156MET A 158THR A 155LEU A 154 | None | 1.43A | 5z86J-2qorA:undetectable | 5z86J-2qorA:14.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rdx | MANDELATERACEMASE/MUCONATELACTONIZING ENZYME,PUTATIVE (Roseovariusnubinhibens) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | TYR A 159MET A 135THR A 320LEU A 342 | None | 1.43A | 5z86J-2rdxA:undetectable | 5z86J-2rdxA:11.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rkc | HEMAGGLUTININ (Measlesmorbillivirus) |
PF00423(HN) | 4 | ARG A 355MET A 441THR A 455LEU A 454 | None | 1.30A | 5z86J-2rkcA:undetectable | 5z86J-2rkcA:10.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rs9 | PEREGRIN (Homo sapiens) |
PF00439(Bromodomain) | 4 | TYR B 102ARG B 101MET B 93THR B 92 | None | 1.37A | 5z86J-2rs9B:undetectable | 5z86J-2rs9B:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x0q | ALCALIGINBIOSYNTHESIS PROTEIN (Bordetellabronchiseptica) |
PF04183(IucA_IucC)PF06276(FhuF) | 4 | TYR A 511MET A 395THR A 394LEU A 455 | None | 1.36A | 5z86J-2x0qA:undetectable | 5z86J-2x0qA:11.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x24 | ACETYL-COACARBOXYLASE (Bos taurus) |
PF01039(Carboxyl_trans) | 4 | ARG A 111MET A 100THR A 101LEU A 68 | None | 1.43A | 5z86J-2x24A:undetectable | 5z86J-2x24A:5.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xhe | SYNTAXIN1 (Monosigabrevicollis) |
PF00804(Syntaxin)PF05739(SNARE) | 4 | TYR B 154MET B 94THR B 93LEU B 90 | None | 1.38A | 5z86J-2xheB:undetectable | 5z86J-2xheB:13.69 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2y69 | CYTOCHROME C OXIDASEPOLYPEPTIDE 7A1 (Bos taurus) |
PF02238(COX7a) | 4 | TYR J 32ARG J 33MET J 36LEU J 40 | None | 1.18A | 5z86J-2y69J:8.0 | 5z86J-2y69J:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2y69 | CYTOCHROME C OXIDASEPOLYPEPTIDE 7A1 (Bos taurus) |
PF02238(COX7a) | 4 | TYR J 32MET J 36THR J 37LEU J 40 | None | 0.11A | 5z86J-2y69J:8.0 | 5z86J-2y69J:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ziu | MUS81 PROTEIN (Danio rerio) |
PF02732(ERCC4) | 4 | TYR A 471MET A 475THR A 476LEU A 479 | None | 0.82A | 5z86J-2ziuA:undetectable | 5z86J-2ziuA:10.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zsg | AMINOPEPTIDASE P,PUTATIVE (Thermotogamaritima) |
PF00557(Peptidase_M24)PF01321(Creatinase_N) | 4 | ARG A 151MET A 177THR A 176LEU A 173 | None | 0.97A | 5z86J-2zsgA:undetectable | 5z86J-2zsgA:10.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b1f | PUTATIVE PREPHENATEDEHYDROGENASE (Streptococcusmutans) |
PF02153(PDH) | 4 | ARG A 222MET A 224THR A 225LEU A 199 | None | 1.29A | 5z86J-3b1fA:undetectable | 5z86J-3b1fA:11.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b7y | E3 UBIQUITIN-PROTEINLIGASE NEDD4 (Homo sapiens) |
PF00168(C2) | 4 | ARG A 124MET A 248THR A 249LEU A 213 | None | 1.30A | 5z86J-3b7yA:undetectable | 5z86J-3b7yA:21.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b8l | UNCHARACTERIZEDPROTEIN (Novosphingobiumaromaticivorans) |
PF13577(SnoaL_4) | 4 | TYR A 112MET A 130THR A 129LEU A 43 | GOL A 145 (-4.4A)GOL A 145 ( 3.8A)NoneNone | 1.27A | 5z86J-3b8lA:undetectable | 5z86J-3b8lA:15.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmm | UBIQUITIN-ACTIVATINGENZYME E1 1 (Saccharomycescerevisiae) |
PF00899(ThiF)PF09358(E1_UFD)PF10585(UBA_e1_thiolCys)PF16190(E1_FCCH)PF16191(E1_4HB) | 4 | TYR A 959MET A1001THR A1000LEU A1024 | None | 1.22A | 5z86J-3cmmA:undetectable | 5z86J-3cmmA:5.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e02 | UNCHARACTERIZEDPROTEIN DUF849 (Paraburkholderiaxenovorans) |
PF05853(BKACE) | 4 | ARG A 156MET A 158THR A 159LEU A 189 | EDO A 320 (-4.5A)NoneNoneNone | 1.15A | 5z86J-3e02A:undetectable | 5z86J-3e02A:10.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i7d | SUGAR PHOSPHATEISOMERASE (Ruegeriapomeroyi) |
PF07883(Cupin_2) | 4 | TYR A 128MET A 133THR A 145LEU A 152 | CAC A 164 (-4.3A)NoneNoneNone | 1.40A | 5z86J-3i7dA:undetectable | 5z86J-3i7dA:16.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ig2 | PHENYLALANYL-TRNASYNTHETASE BETACHAIN (Bacteroidesfragilis) |
no annotation | 4 | TYR A 593MET A 561THR A 531LEU A 530 | None | 1.10A | 5z86J-3ig2A:undetectable | 5z86J-3ig2A:16.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jb9 | SMALL NUCLEARRIBONUCLEOPROTEIN SMD3 (Schizosaccharomycespombe) |
PF01423(LSM) | 4 | ARG D 27MET D 18THR D 25LEU D 20 | None | 1.17A | 5z86J-3jb9D:undetectable | 5z86J-3jb9D:19.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k13 | 5-METHYLTETRAHYDROFOLATE-HOMOCYSTEINEMETHYLTRANSFERASE (Bacteroidesthetaiotaomicron) |
PF00809(Pterin_bind) | 4 | ARG A 407MET A 410THR A 411LEU A 414 | None | 0.74A | 5z86J-3k13A:undetectable | 5z86J-3k13A:11.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nab | FAB15 MUT6 HEAVYCHAIN (Homo sapiens) |
PF07654(C1-set)PF07686(V-set) | 4 | TYR H 91MET H 89THR H 107LEU H 108 | None | 1.33A | 5z86J-3nabH:undetectable | 5z86J-3nabH:14.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ntk | MATERNAL PROTEINTUDOR (Drosophilamelanogaster) |
PF00567(TUDOR) | 4 | TYR A2452MET A2376THR A2377LEU A2380 | None | 1.20A | 5z86J-3ntkA:undetectable | 5z86J-3ntkA:16.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3opb | SWI5-DEPENDENT HOEXPRESSION PROTEIN 4 (Saccharomycescerevisiae) |
PF11701(UNC45-central) | 4 | ARG A 340MET A 379THR A 378LEU A 376 | None | 1.43A | 5z86J-3opbA:undetectable | 5z86J-3opbA:5.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3se7 | VANA (-) |
PF01820(Dala_Dala_lig_N)PF07478(Dala_Dala_lig_C) | 4 | TYR A 315MET A 319THR A 320LEU A 324 | None | 0.94A | 5z86J-3se7A:undetectable | 5z86J-3se7A:10.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ue3 | SEPTUM FORMATION,PENICILLIN BINDINGPROTEIN 3,PEPTIDOGLYCANSYNTHETASE (Acinetobactersp. ATCC 27244) |
PF00905(Transpeptidase)PF03717(PBP_dimer) | 4 | ARG A 373MET A 365THR A 371LEU A 367 | None | 1.09A | 5z86J-3ue3A:undetectable | 5z86J-3ue3A:8.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uji | FAB REGION OF THEHEAVY CHAIN OFANTI-HIV-1 V3MONOCLONAL ANTIBODY2558 (Homo sapiens) |
PF07654(C1-set)PF07686(V-set) | 4 | TYR H 91MET H 89THR H 107LEU H 108 | None | 1.43A | 5z86J-3ujiH:undetectable | 5z86J-3ujiH:13.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3utk | LIPOPROTEIN OUTS (Dickeyadadantii) |
PF09691(T2SS_PulS_OutS) | 4 | ARG A 120MET A 122THR A 123LEU A 126 | None | 1.20A | 5z86J-3utkA:undetectable | 5z86J-3utkA:19.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zxs | CRYPTOCHROME B (Rhodobactersphaeroides) |
PF04244(DPRP) | 4 | TYR A 439ARG A 343MET A 344LEU A 347 | NoneNoneSF4 A1510 (-4.5A)None | 1.15A | 5z86J-3zxsA:undetectable | 5z86J-3zxsA:8.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a1g | MITOTIC CHECKPOINTSERINE/THREONINE-PROTEIN KINASE BUB1 (Homo sapiens) |
PF08311(Mad3_BUB1_I) | 4 | TYR A 140ARG A 141THR A 145LEU A 147 | None | 1.18A | 5z86J-4a1gA:undetectable | 5z86J-4a1gA:17.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4asi | ACETYL-COACARBOXYLASE 1 (Homo sapiens) |
PF01039(Carboxyl_trans) | 4 | ARG A1712MET A1701THR A1702LEU A1669 | None | 1.42A | 5z86J-4asiA:undetectable | 5z86J-4asiA:6.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4feq | TYROSINE-PROTEINKINASE RECEPTORTYRO3 (Mus musculus) |
PF07714(Pkinase_Tyr) | 4 | ARG A 624MET A 657THR A 658LEU A 653 | None | 0.99A | 5z86J-4feqA:undetectable | 5z86J-4feqA:11.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gl2 | INTERFERON-INDUCEDHELICASE CDOMAIN-CONTAININGPROTEIN 1 (Homo sapiens) |
PF00271(Helicase_C)PF04851(ResIII)PF11648(RIG-I_C-RD) | 4 | ARG A 560MET A 558THR A 559LEU A 555 | None | 1.39A | 5z86J-4gl2A:undetectable | 5z86J-4gl2A:7.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h3t | CRISPR-ASSOCIATEDPROTEIN, CSE1 FAMILY (Acidimicrobiumferrooxidans) |
PF09481(CRISPR_Cse1) | 4 | TYR A 464ARG A 465THR A 469LEU A 471 | None | 1.43A | 5z86J-4h3tA:undetectable | 5z86J-4h3tA:7.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hwe | FAB HEAVY CHAIN (Homo sapiens) |
PF07654(C1-set)PF07686(V-set) | 4 | TYR H 96MET H 94THR H 113LEU H 114 | None | 1.37A | 5z86J-4hweH:undetectable | 5z86J-4hweH:15.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ina | SACCHAROPINEDEHYDROGENASE (Wolinellasuccinogenes) |
PF03435(Sacchrp_dh_NADP)PF16653(Sacchrp_dh_C) | 4 | TYR A 103MET A 93THR A 91LEU A 90 | None | 1.16A | 5z86J-4inaA:undetectable | 5z86J-4inaA:9.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k0u | LIPOPROTEIN OUTS (Dickeyadadantii) |
PF09691(T2SS_PulS_OutS) | 4 | ARG A 120MET A 122THR A 123LEU A 126 | None | 0.99A | 5z86J-4k0uA:undetectable | 5z86J-4k0uA:20.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k3b | OUTER MEMBRANEPROTEIN ASSEMBLYFACTOR BAMA (Neisseriagonorrhoeae) |
PF01103(Bac_surface_Ag)PF07244(POTRA) | 4 | TYR A 296MET A 301THR A 302LEU A 305 | None | 0.98A | 5z86J-4k3bA:undetectable | 5z86J-4k3bA:5.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kmr | TRANSCRIPTIONALREGULATOR, LACIFAMILY (Sanguibacterkeddieii) |
PF13377(Peripla_BP_3) | 4 | TYR A 208ARG A 209THR A 213LEU A 217 | None | 1.23A | 5z86J-4kmrA:undetectable | 5z86J-4kmrA:15.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ksd | R2 PROTEIN (Lama glama) |
PF07686(V-set) | 4 | ARG B 19MET B 83THR B 84LEU B 86 | None | 1.42A | 5z86J-4ksdB:undetectable | 5z86J-4ksdB:21.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kv7 | PROBABLELEUCINE/ISOLEUCINE/VALINE-BINDINGPROTEIN (Rhodopirellulabaltica) |
PF13458(Peripla_BP_6) | 4 | TYR A 319ARG A 320MET A 323LEU A 330 | None | 1.09A | 5z86J-4kv7A:undetectable | 5z86J-4kv7A:11.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kxb | GLUTAMYLAMINOPEPTIDASE (Homo sapiens) |
PF01433(Peptidase_M1)PF11838(ERAP1_C) | 4 | ARG A 143MET A 190THR A 189LEU A 188 | None | 0.87A | 5z86J-4kxbA:undetectable | 5z86J-4kxbA:5.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ljs | PERIPLASMIC BINDINGPROTEIN (Veillonellaparvula) |
PF01497(Peripla_BP_2) | 4 | TYR A 99ARG A 314THR A 73LEU A 77 | None | 1.33A | 5z86J-4ljsA:undetectable | 5z86J-4ljsA:11.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ly4 | PEPTIDOGLYCANDEACETYLASE (Helicobacterpylori) |
PF01522(Polysacc_deac_1) | 4 | TYR A 9MET A 244THR A 245LEU A 198 | None | 1.24A | 5z86J-4ly4A:undetectable | 5z86J-4ly4A:10.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n2x | DL-2-HALOACIDDEHALOGENASE (Methylobacteriumsp. CPA1) |
PF10778(DehI) | 4 | ARG A 249MET A 251THR A 252LEU A 255 | None | 0.88A | 5z86J-4n2xA:undetectable | 5z86J-4n2xA:11.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nzu | 13PL LIGHT CHAIN (Homo sapiens) |
PF07654(C1-set)PF07686(V-set) | 4 | ARG H 19MET H 82THR H 17LEU H 82 | None | 1.28A | 5z86J-4nzuH:undetectable | 5z86J-4nzuH:12.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4obs | ALPHA-L-IDURONIDASE (Homo sapiens) |
PF01229(Glyco_hydro_39) | 4 | TYR A 318ARG A 313THR A 364LEU A 365 | None CL A 915 (-4.0A)NoneNone | 1.41A | 5z86J-4obsA:undetectable | 5z86J-4obsA:6.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qi4 | CELLOBIOSEDEHYDROGENASE (Crassicarponhotsonii) |
PF00732(GMC_oxred_N)PF00734(CBM_1)PF05199(GMC_oxred_C) | 4 | TYR A 728ARG A 726THR A 725LEU A 708 | None | 1.42A | 5z86J-4qi4A:undetectable | 5z86J-4qi4A:8.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rae | HISTIDINOL-PHOSPHATEAMINOTRANSFERASE (Mycobacteriumtuberculosis) |
PF00155(Aminotran_1_2) | 4 | ARG A 228MET A 230THR A 229LEU A 241 | None | 1.16A | 5z86J-4raeA:undetectable | 5z86J-4raeA:9.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rm7 | ACYL-COADEHYDROGENASE (Slackiaheliotrinireducens) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N) | 4 | TYR A 322MET A 295THR A 293LEU A 292 | None | 1.20A | 5z86J-4rm7A:undetectable | 5z86J-4rm7A:12.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rwt | LEIOMODIN-2 (Homo sapiens) |
no annotation | 4 | ARG C 309MET C 312THR C 313LEU C 316 | None | 0.56A | 5z86J-4rwtC:undetectable | 5z86J-4rwtC:9.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4upk | PHOSPHONATEMONOESTER HYDROLASE (Ruegeriapomeroyi) |
PF00884(Sulfatase) | 4 | TYR A 257MET A 332THR A 333LEU A 406 | None | 1.24A | 5z86J-4upkA:undetectable | 5z86J-4upkA:8.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wuu | IMMUNOGLOBULIN HEAVYCHAIN (Homo sapiens) |
PF07654(C1-set)PF07686(V-set) | 4 | TYR E 95MET E 93THR E 115LEU E 116 | None | 1.41A | 5z86J-4wuuE:undetectable | 5z86J-4wuuE:14.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zi6 | CYTOSOLAMINOPEPTIDASE (Helicobacterpylori) |
PF00883(Peptidase_M17)PF02789(Peptidase_M17_N) | 4 | TYR A 166MET A 170THR A 171LEU A 174 | None | 0.40A | 5z86J-4zi6A:undetectable | 5z86J-4zi6A:9.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zvi | DNA GYRASE SUBUNIT B (Escherichiacoli) |
PF00204(DNA_gyraseB)PF02518(HATPase_c) | 4 | ARG A 286MET A 289THR A 290LEU A 293 | None | 0.95A | 5z86J-4zviA:undetectable | 5z86J-4zviA:10.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a22 | VESICULAR STOMATITISVIRUS L POLYMERASE (Vesicularstomatitisvirus) |
PF00946(Mononeg_RNA_pol)PF14314(Methyltrans_Mon)PF14318(Mononeg_mRNAcap) | 4 | ARG A1215MET A1198THR A1199LEU A1201 | None | 1.43A | 5z86J-5a22A:undetectable | 5z86J-5a22A:2.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a96 | POLYHEDRIN (Cypovirus 14) |
PF17515(CPV_Polyhedrin) | 4 | ARG A 168MET A 173THR A 172LEU A 61 | GTP A1250 (-4.3A)NoneNoneNone | 1.26A | 5z86J-5a96A:undetectable | 5z86J-5a96A:12.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5aov | GLYOXYLATE REDUCTASE (Pyrococcusfuriosus) |
PF00389(2-Hacid_dh)PF02826(2-Hacid_dh_C) | 4 | TYR A 220MET A 219THR A 218LEU A 214 | EDO A1351 (-3.4A)1PE A1349 (-4.2A)NAP A1335 (-4.2A)1PE A1345 (-4.5A) | 1.35A | 5z86J-5aovA:undetectable | 5z86J-5aovA:13.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b0n | E3 UBIQUITIN-PROTEINLIGASE IPAH9.8 (Shigellaflexneri) |
PF12468(TTSSLRR) | 4 | ARG A 163MET A 142THR A 141LEU A 122 | None | 1.13A | 5z86J-5b0nA:undetectable | 5z86J-5b0nA:11.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5by7 | 3-OXOACYL-ACPSYNTHASE III (Verrucosisporamaris) |
PF08541(ACP_syn_III_C)PF08545(ACP_syn_III) | 4 | ARG A 254MET A 255THR A 256LEU A 251 | None | 1.38A | 5z86J-5by7A:undetectable | 5z86J-5by7A:8.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dum | 65C6 HEAVY CHAIN (Homo sapiens) |
PF07654(C1-set)PF07686(V-set) | 4 | TYR H 95MET H 93THR H 121LEU H 122 | None | 1.40A | 5z86J-5dumH:undetectable | 5z86J-5dumH:11.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ezr | CGMP-DEPENDENTPROTEIN KINASE,PUTATIVE (Plasmodiumvivax) |
PF00027(cNMP_binding)PF00069(Pkinase) | 4 | ARG A 276MET A 279THR A 280LEU A 283 | None | 0.85A | 5z86J-5ezrA:undetectable | 5z86J-5ezrA:6.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f96 | HEAVY CHAIN OFANTIBODY CH235.12 (Homo sapiens) |
PF07654(C1-set)PF07686(V-set) | 4 | ARG H 82MET H 18THR H 19LEU H 20 | None | 1.40A | 5z86J-5f96H:undetectable | 5z86J-5f96H:13.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fdn | PHOSPHOENOLPYRUVATECARBOXYLASE 3 (Arabidopsisthaliana) |
PF00311(PEPcase) | 4 | ARG A 666MET A 634THR A 633LEU A 632 | None | 1.09A | 5z86J-5fdnA:undetectable | 5z86J-5fdnA:4.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g56 | CARBOHYDRATE BINDINGFAMILY 6 (Ruminiclostridiumthermocellum) |
PF00150(Cellulase)PF03422(CBM_6) | 4 | TYR A 75ARG A 121THR A 122LEU A 127 | None | 1.29A | 5z86J-5g56A:undetectable | 5z86J-5g56A:4.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gnc | AVH146 (Phytophthorasojae) |
no annotation | 4 | TYR A 232MET A 228THR A 227LEU A 224 | None | 0.94A | 5z86J-5gncA:undetectable | 5z86J-5gncA:7.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ic8 | PUTATIVEUNCHARACTERIZEDPROTEIN (Chaetomiumthermophilum) |
no annotation | 4 | ARG A 127MET A 130THR A 131LEU A 134 | None | 0.56A | 5z86J-5ic8A:undetectable | 5z86J-5ic8A:11.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5iig | VACUOLAR TRANSPORTERCHAPERONE 4 (Saccharomycescerevisiae) |
PF03105(SPX)PF09359(VTC) | 4 | ARG A 356MET A 382THR A 381LEU A 380 | None | 0.96A | 5z86J-5iigA:undetectable | 5z86J-5iigA:9.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5iy9 | DNA-DIRECTED RNAPOLYMERASE IISUBUNIT RPB1 (Homo sapiens) |
PF00623(RNA_pol_Rpb1_2)PF04983(RNA_pol_Rpb1_3)PF04990(RNA_pol_Rpb1_7)PF04992(RNA_pol_Rpb1_6)PF04997(RNA_pol_Rpb1_1)PF04998(RNA_pol_Rpb1_5)PF05000(RNA_pol_Rpb1_4) | 4 | ARG A1408MET A1405THR A1404LEU A1401 | None | 1.30A | 5z86J-5iy9A:undetectable | 5z86J-5iy9A:2.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m32 | 26S PROTEASEREGULATORY SUBUNIT 4 (Homo sapiens) |
PF00227(Proteasome)PF10584(Proteasome_A_N) | 4 | ARG d 307MET d 309THR d 308LEU d 312 | None | 1.39A | 5z86J-5m32d:undetectable | 5z86J-5m32d:9.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nm7 | PEPTIDOGLYCAN-BINDING DOMAIN 1 (Burkholderia) |
no annotation | 4 | TYR G 117ARG G 119MET G 122LEU G 126 | None | 0.91A | 5z86J-5nm7G:undetectable | 5z86J-5nm7G:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nqd | ARSENITE OXIDASELARGE SUBUNIT AIOA[3FE-4S] CLUSTER,MO-MOLYBDOPTERINCOFACTOR-BINDINGACTIVE SITE (Rhizobium sp.NT-26) |
no annotation | 4 | ARG A 149MET A 604THR A 603LEU A 600 | None | 1.16A | 5z86J-5nqdA:undetectable | 5z86J-5nqdA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o3w | PEPTIDE CYCLASE 1 (Gypsophilavaccaria) |
no annotation | 4 | TYR A 642MET A 668THR A 667LEU A 664 | None | 1.34A | 5z86J-5o3wA:undetectable | 5z86J-5o3wA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o6v | FAB 19/1786 - HEAVYCHAIN (Mus musculus) |
no annotation | 4 | TYR H 95MET H 93THR H 114LEU H 115 | None | 1.42A | 5z86J-5o6vH:undetectable | 5z86J-5o6vH:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t1v | NS2B-NS3PROTEASE,NS2B-NS3PROTEASE (Zika virus) |
PF00949(Peptidase_S7)PF01002(Flavi_NS2B) | 4 | TYR A 9ARG A 93MET A 91THR A 99 | None | 1.32A | 5z86J-5t1vA:undetectable | 5z86J-5t1vA:12.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tro | PENICILLIN-BINDINGPROTEIN 1 (Staphylococcusaureus) |
PF00905(Transpeptidase)PF03717(PBP_dimer) | 4 | ARG A 341MET A 373THR A 371LEU A 372 | None | 1.42A | 5z86J-5troA:undetectable | 5z86J-5troA:7.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u0u | DH270.1 SINGLE-CHAINVARIABLE FRAGMENT (Homo sapiens) |
no annotation | 4 | TYR G 95MET G 93THR G 121LEU G 122 | None | 1.32A | 5z86J-5u0uG:undetectable | 5z86J-5u0uG:11.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uc2 | DOMAIN OF UNKNOWNFUNCTION DUF1849 (Brucellaabortus) |
PF08904(DUF1849) | 4 | TYR A 235MET A 252THR A 251LEU A 250 | None | 1.27A | 5z86J-5uc2A:undetectable | 5z86J-5uc2A:14.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v6b | PDZDOMAIN-CONTAININGPROTEIN GIPC1 (Mus musculus) |
PF00595(PDZ) | 4 | ARG A 307MET A 287THR A 286LEU A 283 | None | 1.32A | 5z86J-5v6bA:undetectable | 5z86J-5v6bA:14.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vfz | GP33 (Mycobacteriumvirus Brujita) |
no annotation | 4 | ARG A 169MET A 171THR A 170LEU A 183 | None | 1.36A | 5z86J-5vfzA:undetectable | 5z86J-5vfzA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vqh | TUDOR AND KHDOMAIN-CONTAININGPROTEIN HOMOLOG (Bombyx mori) |
PF00567(TUDOR) | 4 | TYR A 39ARG A 45THR A 49LEU A 50 | None | 1.27A | 5z86J-5vqhA:undetectable | 5z86J-5vqhA:11.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vxz | GROWTHARREST-SPECIFICPROTEIN 6 (Homo sapiens) |
PF00054(Laminin_G_1)PF02210(Laminin_G_2) | 4 | TYR A 480MET A 644THR A 645LEU A 646 | None | 1.36A | 5z86J-5vxzA:undetectable | 5z86J-5vxzA:8.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xk8 | UNDECAPRENYLDIPHOSPHATE SYNTHASE (Streptomycessp. CNH189) |
no annotation | 4 | TYR A 26MET A 29THR A 30LEU A 33 | None | 1.04A | 5z86J-5xk8A:undetectable | 5z86J-5xk8A:undetectable |