SIMILAR PATTERNS OF AMINO ACIDS FOR 5Z86_B_CHDB302
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1d2e | ELONGATION FACTOR TU(EF-TU) (Bos taurus) |
PF00009(GTP_EFTU)PF03143(GTP_EFTU_D3)PF03144(GTP_EFTU_D2) | 5 | GLY A 172GLN A 170THR A 437PHE A 206GLY A 207 | None | 1.43A | 5z86A-1d2eA:0.05z86B-1d2eA:0.05z86T-1d2eA:0.0 | 5z86A-1d2eA:21.965z86B-1d2eA:19.615z86T-1d2eA:12.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k5s | PENICILLIN G ACYLASEBETA SUBUNIT (Escherichiacoli) |
PF01804(Penicil_amidase) | 5 | MET B 485GLU B 482THR B 481PHE B 531GLY B 532 | None | 1.20A | 5z86A-1k5sB:2.75z86B-1k5sB:0.05z86T-1k5sB:0.0 | 5z86A-1k5sB:20.535z86B-1k5sB:17.455z86T-1k5sB:12.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wk4 | TTK003001606 (Thermusthermophilus) |
PF00583(Acetyltransf_1) | 5 | GLN A 101THR A 21THR A 25PHE A 139GLY A 136 | NoneNoneNoneMES A 201 ( 4.3A)MES A 201 (-3.3A) | 1.13A | 5z86A-1wk4A:undetectable5z86B-1wk4A:0.05z86T-1wk4A:0.0 | 5z86A-1wk4A:14.655z86B-1wk4A:21.155z86T-1wk4A:18.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zr6 | GLUCOOLIGOSACCHARIDEOXIDASE (Sarocladiumstrictum) |
PF01565(FAD_binding_4)PF08031(BBE) | 5 | GLY A 79GLN A 62GLU A 80PHE A 464GLY A 190 | NoneNoneNoneNoneFAD A 501 (-3.4A) | 1.48A | 5z86A-1zr6A:0.65z86B-1zr6A:0.05z86T-1zr6A:0.0 | 5z86A-1zr6A:21.865z86B-1zr6A:17.475z86T-1zr6A:10.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gsk | VITAMIN B12TRANSPORTER BTUB (Escherichiacoli) |
PF00593(TonB_dep_Rec)PF07715(Plug) | 5 | GLY A 119GLN A 372THR A 391ARG A 19GLY A 125 | None | 1.31A | 5z86A-2gskA:undetectable5z86B-2gskA:0.05z86T-2gskA:0.0 | 5z86A-2gskA:21.565z86B-2gskA:14.485z86T-2gskA:10.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qa1 | POLYKETIDE OXYGENASEPGAE (Streptomycessp. PGA64) |
PF01494(FAD_binding_3) | 5 | GLY A 11GLN A 96GLU A 100THR A 38GLY A 153 | FAD A 500 (-3.5A)FAD A 500 (-2.9A)NoneNoneFAD A 500 (-3.6A) | 1.48A | 5z86A-2qa1A:0.45z86B-2qa1A:0.05z86T-2qa1A:0.0 | 5z86A-2qa1A:21.715z86B-2qa1A:18.045z86T-2qa1A:13.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qua | EXTRACELLULAR LIPASE (Serratiamarcescens) |
no annotation | 5 | GLY A 181GLU A 112THR A 117THR A 113GLY A 174 | None | 1.44A | 5z86A-2quaA:0.05z86B-2quaA:0.55z86T-2quaA:0.0 | 5z86A-2quaA:21.915z86B-2quaA:15.425z86T-2quaA:9.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bt7 | TRNA(URACIL-5-)-METHYLTRANSFERASE (Escherichiacoli) |
PF05958(tRNA_U5-meth_tr) | 5 | MET A 179GLU A 170ARG A 230PHE A 224GLY A 222 | None | 1.39A | 5z86A-3bt7A:0.05z86B-3bt7A:0.05z86T-3bt7A:0.0 | 5z86A-3bt7A:20.945z86B-3bt7A:20.405z86T-3bt7A:13.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ce6 | ADENOSYLHOMOCYSTEINASE (Mycobacteriumtuberculosis) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | GLY A 359THR A 269ARG A 406PHE A 96GLY A 411 | None | 1.34A | 5z86A-3ce6A:0.05z86B-3ce6A:0.05z86T-3ce6A:0.0 | 5z86A-3ce6A:22.595z86B-3ce6A:18.095z86T-3ce6A:12.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cvr | INVASION PLASMIDANTIGEN (Shigellaflexneri) |
PF12468(TTSSLRR)PF14496(NEL) | 5 | MET A 402GLY A 399THR A 392ARG A 375GLY A 484 | None | 1.42A | 5z86A-3cvrA:0.45z86B-3cvrA:undetectable5z86T-3cvrA:undetectable | 5z86A-3cvrA:22.785z86B-3cvrA:18.505z86T-3cvrA:9.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fgb | UNCHARACTERIZEDPROTEIN Q89ZH8_BACTN (Bacteroidesthetaiotaomicron) |
PF10282(Lactonase) | 5 | GLY A 153THR A 129ARG A 112PHE A 104GLY A 83 | None | 1.33A | 5z86A-3fgbA:undetectable5z86B-3fgbA:undetectable5z86T-3fgbA:undetectable | 5z86A-3fgbA:20.445z86B-3fgbA:21.475z86T-3fgbA:13.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hdj | PROBABLE ORNITHINECYCLODEAMINASE (Bordetellapertussis) |
PF02423(OCD_Mu_crystall) | 5 | GLY A 285GLU A 233ARG A 41ARG A 38GLY A 53 | None | 1.24A | 5z86A-3hdjA:0.05z86B-3hdjA:undetectable5z86T-3hdjA:undetectable | 5z86A-3hdjA:20.635z86B-3hdjA:20.695z86T-3hdjA:12.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hn0 | NITRATE TRANSPORTPROTEIN (Parabacteroidesdistasonis) |
no annotation | 5 | GLY A 199GLN A 202THR A 203ARG A 137GLY A 275 | None | 1.44A | 5z86A-3hn0A:undetectable5z86B-3hn0A:undetectable5z86T-3hn0A:undetectable | 5z86A-3hn0A:19.485z86B-3hn0A:21.925z86T-3hn0A:15.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j4u | MAJOR CAPSID PROTEIN (Bordetellavirus BPP1) |
no annotation | 5 | MET A 87GLY A 88GLN A 126THR A 125GLY A 144 | None | 1.42A | 5z86A-3j4uA:undetectable5z86B-3j4uA:undetectable5z86T-3j4uA:undetectable | 5z86A-3j4uA:21.075z86B-3j4uA:21.305z86T-3j4uA:14.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ny7 | SULFATE TRANSPORTER (Escherichiacoli) |
PF01740(STAS) | 5 | GLY A 466THR A 437ARG A 505PHE A 499GLY A 495 | None | 1.11A | 5z86A-3ny7A:undetectable5z86B-3ny7A:undetectable5z86T-3ny7A:undetectable | 5z86A-3ny7A:14.105z86B-3ny7A:20.435z86T-3ny7A:17.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s9b | VIPERA RUSSELLIPROTEINASE RVV-VGAMMA (Daboiasiamensis) |
PF00089(Trypsin) | 5 | GLY A 18ARG A 137ARG A 135PHE A 161GLY A 184 | None | 0.99A | 5z86A-3s9bA:undetectable5z86B-3s9bA:undetectable5z86T-3s9bA:undetectable | 5z86A-3s9bA:19.005z86B-3s9bA:21.015z86T-3s9bA:15.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vn3 | ANTIFREEZE PROTEIN (Typhulaishikariensis) |
PF11999(DUF3494) | 5 | TRP A 142THR A 139THR A 137ARG A 97GLY A 118 | None | 1.45A | 5z86A-3vn3A:0.35z86B-3vn3A:undetectable5z86T-3vn3A:undetectable | 5z86A-3vn3A:18.095z86B-3vn3A:22.585z86T-3vn3A:17.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vrb | FLAVOPROTEIN SUBUNITOF COMPLEX IIIRON-SULFUR SUBUNITOF SUCCINATEDEHYDROGENASE (Ascaris suum;Ascaris suum) |
PF00890(FAD_binding_2)PF02910(Succ_DH_flav_C)PF13085(Fer2_3)PF13534(Fer4_17) | 5 | GLN A 84GLU B 91THR A 366ARG A 320GLY A 279 | NoneFAD A 702 ( 4.4A)NoneFUM A 701 (-3.2A)None | 1.46A | 5z86A-3vrbA:undetectable5z86B-3vrbA:undetectable5z86T-3vrbA:undetectable | 5z86A-3vrbA:22.275z86B-3vrbA:15.625z86T-3vrbA:8.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wrc | GALLATE DIOXYGENASE (Sphingomonaspaucimobilis) |
PF02900(LigB)PF07746(LigA) | 5 | GLN A 277ARG A 167ARG A 247PHE A 274GLY A 7 | None | 1.08A | 5z86A-3wrcA:undetectable5z86B-3wrcA:undetectable5z86T-3wrcA:undetectable | 5z86A-3wrcA:22.005z86B-3wrcA:17.695z86T-3wrcA:10.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wy7 | 8-AMINO-7-OXONONANOATE SYNTHASE (Mycolicibacteriumsmegmatis) |
PF00155(Aminotran_1_2) | 5 | GLY A 214GLU A 201THR A 230THR A 231GLY A 94 | None | 1.36A | 5z86A-3wy7A:undetectable5z86B-3wy7A:undetectable5z86T-3wy7A:undetectable | 5z86A-3wy7A:21.195z86B-3wy7A:19.495z86T-3wy7A:12.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zyt | ESTERASE A (Paenarthrobacternitroguajacolicus) |
PF00144(Beta-lactamase) | 5 | GLY A 154GLN A 170GLU A 158THR A 168GLY A 66 | None | 1.40A | 5z86A-3zytA:undetectable5z86B-3zytA:undetectable5z86T-3zytA:undetectable | 5z86A-3zytA:20.155z86B-3zytA:20.275z86T-3zytA:12.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cgy | DNA TOPOISOMERASE3-ALPHA (Homo sapiens) |
PF01131(Topoisom_bac)PF01751(Toprim) | 5 | MET A 566GLY A 565THR A 544PHE A 559GLY A 552 | None | 1.44A | 5z86A-4cgyA:1.85z86B-4cgyA:undetectable5z86T-4cgyA:undetectable | 5z86A-4cgyA:20.215z86B-4cgyA:12.965z86T-4cgyA:9.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cu8 | GLYCOSIDE HYDROLASE2 (Streptococcuspneumoniae) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N)PF16355(DUF4982) | 5 | GLY A 597GLU A 505THR A 482PHE A 444GLY A 643 | None | 1.32A | 5z86A-4cu8A:undetectable5z86B-4cu8A:undetectable5z86T-4cu8A:undetectable | 5z86A-4cu8A:20.585z86B-4cu8A:14.295z86T-4cu8A:7.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cu8 | GLYCOSIDE HYDROLASE2 (Streptococcuspneumoniae) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N)PF16355(DUF4982) | 5 | GLY A 597THR A 482THR A 483PHE A 444GLY A 643 | None | 1.45A | 5z86A-4cu8A:undetectable5z86B-4cu8A:undetectable5z86T-4cu8A:undetectable | 5z86A-4cu8A:20.585z86B-4cu8A:14.295z86T-4cu8A:7.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j05 | PHOSPHATETRANSPORTER (Serendipitaindica) |
PF00083(Sugar_tr) | 5 | GLY A 315THR A 433THR A 434PHE A 493GLY A 492 | None | 1.22A | 5z86A-4j05A:0.65z86B-4j05A:undetectable5z86T-4j05A:undetectable | 5z86A-4j05A:23.835z86B-4j05A:17.555z86T-4j05A:10.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j9u | TRK SYSTEM POTASSIUMUPTAKE PROTEIN TRKH (Vibrioparahaemolyticus) |
PF02386(TrkH) | 5 | MET A 356GLY A 355THR A 110THR A 112PHE A 466 | None | 1.40A | 5z86A-4j9uA:2.65z86B-4j9uA:undetectable5z86T-4j9uA:undetectable | 5z86A-4j9uA:23.605z86B-4j9uA:18.895z86T-4j9uA:10.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k3y | NEURAMINIDASE (Influenza Avirus) |
PF00064(Neur) | 5 | GLN A 226THR A 239ARG A 406PHE A 277GLY A 291 | None | 1.25A | 5z86A-4k3yA:undetectable5z86B-4k3yA:undetectable5z86T-4k3yA:undetectable | 5z86A-4k3yA:21.725z86B-4k3yA:20.775z86T-4k3yA:11.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lls | GERANYLTRANSTRANSFERASE (Roseobacterdenitrificans) |
PF00348(polyprenyl_synt) | 5 | MET A 149GLY A 177GLN A 175ARG A 44GLY A 184 | GST A 302 ( 4.1A)NoneNoneIPE A 301 (-3.1A)None | 1.46A | 5z86A-4llsA:2.25z86B-4llsA:undetectable5z86T-4llsA:undetectable | 5z86A-4llsA:20.315z86B-4llsA:22.935z86T-4llsA:14.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qdg | PUTATIVE ADHESIN (Bacteroidesthetaiotaomicron) |
PF08842(Mfa2) | 5 | MET A 175THR A 67ARG A 253PHE A 119GLY A 153 | None | 1.37A | 5z86A-4qdgA:undetectable5z86B-4qdgA:undetectable5z86T-4qdgA:undetectable | 5z86A-4qdgA:20.495z86B-4qdgA:23.205z86T-4qdgA:13.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b5h | ANTIFREEZE PROTEIN (Typhulaishikariensis) |
PF11999(DUF3494) | 5 | TRP A 142THR A 139THR A 137ARG A 97GLY A 118 | None | 1.42A | 5z86A-5b5hA:undetectable5z86B-5b5hA:undetectable5z86T-5b5hA:undetectable | 5z86A-5b5hA:21.275z86B-5b5hA:23.115z86T-5b5hA:12.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gl7 | METHIONINE--TRNALIGASE, CYTOPLASMIC (Homo sapiens) |
PF09334(tRNA-synt_1g) | 5 | MET A 659GLY A 658GLN A 770THR A 766GLY A 651 | None | 1.46A | 5z86A-5gl7A:1.65z86B-5gl7A:undetectable5z86T-5gl7A:undetectable | 5z86A-5gl7A:20.775z86B-5gl7A:16.405z86T-5gl7A:8.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5neu | INTEGRIN ALPHA-V (Homo sapiens) |
PF01839(FG-GAP)PF08441(Integrin_alpha2) | 5 | GLY A 269GLN A 314GLU A 270THR A 328GLY A 277 | None | 1.49A | 5z86A-5neuA:undetectable5z86B-5neuA:undetectable5z86T-5neuA:undetectable | 5z86A-5neuA:23.105z86B-5neuA:15.765z86T-5neuA:8.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6brd | RIFAMPINMONOOXYGENASE (Streptomycesvenezuelae) |
no annotation | 5 | GLY A 9GLN A 98GLU A 102THR A 37GLY A 152 | FAD A 501 ( 4.9A)FAD A 501 (-3.4A)NoneNoneFAD A 501 (-3.2A) | 1.49A | 5z86A-6brdA:0.65z86B-6brdA:undetectable5z86T-6brdA:undetectable | 5z86A-6brdA:undetectable5z86B-6brdA:undetectable5z86T-6brdA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6brd | RIFAMPINMONOOXYGENASE (Streptomycesvenezuelae) |
no annotation | 5 | GLY A 10GLN A 98GLU A 102THR A 37GLY A 152 | FAD A 501 (-3.2A)FAD A 501 (-3.4A)NoneNoneFAD A 501 (-3.2A) | 1.32A | 5z86A-6brdA:0.65z86B-6brdA:undetectable5z86T-6brdA:undetectable | 5z86A-6brdA:undetectable5z86B-6brdA:undetectable5z86T-6brdA:undetectable |