SIMILAR PATTERNS OF AMINO ACIDS FOR 5Z84_W_CHDW101_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1auz SPOIIAA

(Bacillus
subtilis) 		PF01740
(STAS) 		4 ILE A  82
PHE A 101
ARG A  16
THR A  18
 None
 1.19A 5z84N-1auzA:
undetectable
5z84W-1auzA:
0.0		 5z84N-1auzA:
13.62
5z84W-1auzA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hu8 CELLULAR TUMOR
ANTIGEN P53

(Mus musculus) 		PF00870
(P53) 		4 ILE A 252
PHE A 267
TYR A 233
THR A 137
 None
 1.01A 5z84N-1hu8A:
undetectable
5z84W-1hu8A:
0.0		 5z84N-1hu8A:
15.26
5z84W-1hu8A:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i5p PESTICIDIAL CRYSTAL
PROTEIN CRY2AA

(Bacillus
thuringiensis) 		PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N)
PF09131
(Endotoxin_mid) 		4 ILE A 622
PHE A 624
ARG A 533
THR A 560
 None
 1.29A 5z84N-1i5pA:
3.0
5z84W-1i5pA:
0.0		 5z84N-1i5pA:
23.40
5z84W-1i5pA:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE

(Sulfolobus
acidocaldarius) 		PF00128
(Alpha-amylase)
PF09196
(DUF1953) 		4 ILE A 125
PHE A 118
ARG A 192
THR A 198
 None
 1.18A 5z84N-1iv8A:
0.0
5z84W-1iv8A:
0.0		 5z84N-1iv8A:
20.68
5z84W-1iv8A:
5.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k4j ACYL-HOMOSERINELACTO
NE SYNTHASE ESAI

(Pantoea
stewartii) 		PF00765
(Autoind_synth) 		4 ILE A 141
PHE A  86
ARG A 170
THR A 166
 REO  A 407 (-4.6A)
None
None
None
 0.86A 5z84N-1k4jA:
0.9
5z84W-1k4jA:
0.0		 5z84N-1k4jA:
18.26
5z84W-1k4jA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lo3 IG GAMMA 2A HEAVY
CHAIN

(Mus musculus) 		no annotation 4 ILE Y  66
PHE Y  70
TYR Y  96
THR Y  40
 None
 1.30A 5z84N-1lo3Y:
undetectable
5z84W-1lo3Y:
0.0		 5z84N-1lo3Y:
18.64
5z84W-1lo3Y:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mvh CRYPTIC LOCI
REGULATOR 4

(Schizosaccharomyces
pombe) 		PF00856
(SET)
PF05033
(Pre-SET) 		4 ILE A 354
PHE A 408
ARG A 343
THR A 222
 None
 1.20A 5z84N-1mvhA:
undetectable
5z84W-1mvhA:
0.0		 5z84N-1mvhA:
18.42
5z84W-1mvhA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ot5 KEXIN

(Saccharomyces
cerevisiae) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		4 ILE A 570
PHE A 583
ARG A 587
THR A 553
 None
 1.01A 5z84N-1ot5A:
0.0
5z84W-1ot5A:
0.0		 5z84N-1ot5A:
21.15
5z84W-1ot5A:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pm2 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 1
BETA CHAIN

(Escherichia
coli) 		PF00268
(Ribonuc_red_sm) 		4 ILE A 335
TYR A 310
ARG A 328
THR A 312
 None
None
HG  A 614 ( 4.9A)
None
 1.21A 5z84N-1pm2A:
0.8
5z84W-1pm2A:
0.0		 5z84N-1pm2A:
19.19
5z84W-1pm2A:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rii 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Mycobacterium
tuberculosis) 		PF00300
(His_Phos_1) 		4 ILE A 180
TYR A 163
ARG A  87
THR A 165
 None
 1.29A 5z84N-1riiA:
undetectable
5z84W-1riiA:
undetectable		 5z84N-1riiA:
18.79
5z84W-1riiA:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svz SINGLE-CHAIN FV
FRAGMENT 1696

(Mus musculus) 		PF07686
(V-set) 		4 ILE A 233
PHE A 234
TYR A 174
THR A 186
 None
 1.15A 5z84N-1svzA:
undetectable
5z84W-1svzA:
undetectable		 5z84N-1svzA:
19.08
5z84W-1svzA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdk L-AMINO ACID OXIDASE

(Gloydius halys) 		PF01593
(Amino_oxidase) 		4 ILE A 264
PHE A 304
ARG A 301
THR A 295
 None
None
None
FAD  A 488 ( 4.7A)
 1.26A 5z84N-1tdkA:
0.0
5z84W-1tdkA:
undetectable		 5z84N-1tdkA:
20.19
5z84W-1tdkA:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tyd TYROSYL-TRNA
SYNTHETASE

(Geobacillus
stearothermophilus) 		PF00579
(tRNA-synt_1b) 		4 ILE E  46
PHE E 254
TYR E 266
THR E 224
 None
 1.24A 5z84N-1tydE:
0.0
5z84W-1tydE:
undetectable		 5z84N-1tydE:
18.76
5z84W-1tydE:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vc4 INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE

(Thermus
thermophilus) 		PF00218
(IGPS) 		4 ILE A 135
PHE A 114
ARG A 183
THR A 187
 None
 1.17A 5z84N-1vc4A:
0.0
5z84W-1vc4A:
undetectable		 5z84N-1vc4A:
19.76
5z84W-1vc4A:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wh0 UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 19

(Homo sapiens) 		PF04969
(CS) 		4 ILE A 103
PHE A  98
ARG A  47
THR A  78
 None
 1.11A 5z84N-1wh0A:
undetectable
5z84W-1wh0A:
undetectable		 5z84N-1wh0A:
14.85
5z84W-1wh0A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xez HEMOLYSIN

(Vibrio cholerae) 		PF07968
(Leukocidin)
PF12563
(Hemolysin_N)
PF16458
(Beta-prism_lec) 		4 ILE A 146
PHE A 144
ARG A  75
THR A 399
 None
 1.30A 5z84N-1xezA:
0.0
5z84W-1xezA:
undetectable		 5z84N-1xezA:
20.74
5z84W-1xezA:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xgy K42-41L FAB LIGHT
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ILE L 117
PHE L 209
ARG L 155
THR L 180
 None
 1.30A 5z84N-1xgyL:
undetectable
5z84W-1xgyL:
undetectable		 5z84N-1xgyL:
16.60
5z84W-1xgyL:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii) 		PF09043
(Lys-AminoMut_A) 		4 ILE A 442
PHE A 444
ARG A 361
THR A 396
 None
 1.15A 5z84N-1xrsA:
undetectable
5z84W-1xrsA:
undetectable		 5z84N-1xrsA:
21.29
5z84W-1xrsA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zvt TOPOISOMERASE IV
SUBUNIT A

(Escherichia
coli) 		PF03989
(DNA_gyraseA_C) 		4 ILE A 555
PHE A 545
ARG A 511
THR A 501
 None
 1.27A 5z84N-1zvtA:
undetectable
5z84W-1zvtA:
undetectable		 5z84N-1zvtA:
18.25
5z84W-1zvtA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4e 5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
SEMIALDEHYDE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00171
(Aldedh) 		4 ILE A  95
PHE A 132
ARG A  88
THR A 192
 None
 1.29A 5z84N-2d4eA:
undetectable
5z84W-2d4eA:
undetectable		 5z84N-2d4eA:
21.68
5z84W-2d4eA:
7.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA

(Escherichia
coli) 		PF03054
(tRNA_Me_trans) 		4 ILE A 329
PHE A 300
ARG A 305
THR A 307
 None
 1.29A 5z84N-2detA:
undetectable
5z84W-2detA:
undetectable		 5z84N-2detA:
21.21
5z84W-2detA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dn4 GENERAL
TRANSCRIPTION FACTOR
II-I

(Homo sapiens) 		PF02946
(GTF2I) 		4 ILE A  76
PHE A  16
TYR A  61
ARG A  65
 None
 1.16A 5z84N-2dn4A:
undetectable
5z84W-2dn4A:
undetectable		 5z84N-2dn4A:
12.30
5z84W-2dn4A:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fzw ALCOHOL
DEHYDROGENASE CLASS
III CHI CHAIN

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ILE A 249
PHE A 197
ARG A 311
THR A 302
 None
 1.27A 5z84N-2fzwA:
undetectable
5z84W-2fzwA:
undetectable		 5z84N-2fzwA:
20.41
5z84W-2fzwA:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ki7 RIBONUCLEASE P
PROTEIN COMPONENT 1
RIBONUCLEASE P
PROTEIN COMPONENT 4

(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		PF01868
(UPF0086)
PF04032
(Rpr2) 		4 ILE A  23
PHE A  30
TYR B  39
ARG B  38
 None
 1.27A 5z84N-2ki7A:
undetectable
5z84W-2ki7A:
undetectable		 5z84N-2ki7A:
12.26
5z84W-2ki7A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n7p PUTATIVE
UNCHARACTERIZED
PROTEIN

(Trypanosoma
brucei) 		no annotation 4 ILE A  25
PHE A   9
ARG A  58
THR A  65
 None
 1.28A 5z84N-2n7pA:
undetectable
5z84W-2n7pA:
undetectable		 5z84N-2n7pA:
10.70
5z84W-2n7pA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4b SIGMA-E FACTOR
REGULATORY PROTEIN
RSEB

(Escherichia
coli) 		PF03888
(MucB_RseB)
PF17188
(MucB_RseB_C) 		4 ILE A 296
PHE A 261
ARG A 307
THR A 225
 None
 1.15A 5z84N-2p4bA:
undetectable
5z84W-2p4bA:
undetectable		 5z84N-2p4bA:
17.90
5z84W-2p4bA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q05 DUAL SPECIFICITY
PROTEIN PHOSPHATASE

(Vaccinia virus) 		PF00782
(DSPc) 		4 ILE A 162
PHE A  89
ARG A 116
THR A  83
 None
 1.18A 5z84N-2q05A:
undetectable
5z84W-2q05A:
undetectable		 5z84N-2q05A:
15.74
5z84W-2q05A:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q7s N-FORMYLGLUTAMATE
AMIDOHYDROLASE

(Cupriavidus
pinatubonensis) 		PF05013
(FGase) 		4 ILE A 250
PHE A 192
ARG A 272
THR A 275
 None
 0.86A 5z84N-2q7sA:
undetectable
5z84W-2q7sA:
undetectable		 5z84N-2q7sA:
19.19
5z84W-2q7sA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wfx HEDGEHOG-INTERACTING
PROTEIN

(Homo sapiens) 		PF07995
(GSDH) 		4 ILE B 253
PHE B 243
TYR B 293
THR B 325
 None
 1.11A 5z84N-2wfxB:
undetectable
5z84W-2wfxB:
undetectable		 5z84N-2wfxB:
19.85
5z84W-2wfxB:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wgy CYTOCHROME P450 130

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		4 ILE A 139
PHE A 401
ARG A 374
THR A 369
 None
 1.00A 5z84N-2wgyA:
undetectable
5z84W-2wgyA:
undetectable		 5z84N-2wgyA:
22.20
5z84W-2wgyA:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3c TOXIC EXTRACELLULAR
ENDOPEPTIDASE

(Aeromonas
salmonicida) 		PF14521
(Aspzincin_M35) 		4 ILE A 123
PHE A  68
ARG A  39
THR A 182
 None
None
SO4  A1344 ( 3.2A)
None
 1.27A 5z84N-2x3cA:
0.7
5z84W-2x3cA:
undetectable		 5z84N-2x3cA:
20.64
5z84W-2x3cA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y6g XYLANASE

(Rhodothermus
marinus) 		PF02018
(CBM_4_9) 		4 ILE A 164
PHE A 132
ARG A  81
THR A 139
 None
 1.17A 5z84N-2y6gA:
undetectable
5z84W-2y6gA:
undetectable		 5z84N-2y6gA:
18.09
5z84W-2y6gA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ylk CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Ruminiclostridium
thermocellum) 		PF00942
(CBM_3) 		4 ILE A  18
PHE A  98
TYR A   6
THR A 119
 None
 1.16A 5z84N-2ylkA:
undetectable
5z84W-2ylkA:
undetectable		 5z84N-2ylkA:
14.74
5z84W-2ylkA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5d UBIQUITIN-CONJUGATIN
G ENZYME E2 H

(Homo sapiens) 		PF00179
(UQ_con) 		4 ILE A 123
PHE A 124
ARG A  73
THR A 104
 None
 1.30A 5z84N-2z5dA:
undetectable
5z84W-2z5dA:
undetectable		 5z84N-2z5dA:
14.79
5z84W-2z5dA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a8k AMINOMETHYLTRANSFERA
SE

(Escherichia
coli) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		4 ILE A 333
PHE A 299
ARG A 328
THR A 277
 None
 1.31A 5z84N-3a8kA:
undetectable
5z84W-3a8kA:
undetectable		 5z84N-3a8kA:
22.87
5z84W-3a8kA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3asm RIBONUCLEASE HIII

(Geobacillus
stearothermophilus) 		PF01351
(RNase_HII)
PF11858
(DUF3378) 		4 ILE A 201
PHE A 204
ARG A 182
THR A 155
 None
 1.27A 5z84N-3asmA:
undetectable
5z84W-3asmA:
undetectable		 5z84N-3asmA:
19.81
5z84W-3asmA:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c65 UVRABC SYSTEM
PROTEIN C

(Geobacillus
kaustophilus) 		PF08459
(UvrC_HhH_N) 		4 ILE A 450
PHE A 384
ARG A 433
THR A 437
 None
 1.12A 5z84N-3c65A:
undetectable
5z84W-3c65A:
undetectable		 5z84N-3c65A:
16.02
5z84W-3c65A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f83 FUSION OF THE MINOR
PILIN CFAE AND MAJOR
PILIN CFAB

(Escherichia
coli) 		PF04449
(Fimbrial_CS1)
PF07434
(CblD) 		4 ILE A 111
PHE A 167
ARG A 108
THR A 307
 None
 1.29A 5z84N-3f83A:
undetectable
5z84W-3f83A:
undetectable		 5z84N-3f83A:
22.45
5z84W-3f83A:
8.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fk3 PROTEIN AF-9 HOMOLOG

(Saccharomyces
cerevisiae) 		PF03366
(YEATS) 		4 ILE A  96
PHE A  64
ARG A  48
THR A  23
 None
 1.27A 5z84N-3fk3A:
undetectable
5z84W-3fk3A:
undetectable		 5z84N-3fk3A:
13.57
5z84W-3fk3A:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kt4 PKHD-TYPE
HYDROXYLASE TPA1

(Saccharomyces
cerevisiae) 		PF10637
(Ofd1_CTDD)
PF13661
(2OG-FeII_Oxy_4) 		4 ILE A 215
TYR A 245
ARG A 126
THR A 143
 None
 1.27A 5z84N-3kt4A:
undetectable
5z84W-3kt4A:
undetectable		 5z84N-3kt4A:
19.94
5z84W-3kt4A:
7.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kve L-AMINO ACID OXIDASE

(Vipera
ammodytes) 		PF01593
(Amino_oxidase) 		4 ILE A 264
PHE A 304
ARG A 301
THR A 295
 None
None
None
FAD  A 487 (-4.5A)
 1.08A 5z84N-3kveA:
undetectable
5z84W-3kveA:
undetectable		 5z84N-3kveA:
21.17
5z84W-3kveA:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llc PUTATIVE HYDROLASE

(Agrobacterium
vitis) 		PF12697
(Abhydrolase_6) 		4 ILE A 153
PHE A 148
TYR A  45
ARG A  46
 PG4  A 277 ( 4.6A)
PG4  A 277 ( 4.1A)
None
None
 1.20A 5z84N-3llcA:
undetectable
5z84W-3llcA:
undetectable		 5z84N-3llcA:
20.12
5z84W-3llcA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3olm E3 UBIQUITIN-PROTEIN
LIGASE RSP5

(Saccharomyces
cerevisiae) 		PF00397
(WW)
PF00632
(HECT) 		4 ILE A 464
PHE A 488
ARG A 560
THR A 740
 None
 1.16A 5z84N-3olmA:
undetectable
5z84W-3olmA:
undetectable		 5z84N-3olmA:
20.60
5z84W-3olmA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qpc CUTINASE

(Fusarium solani) 		PF01083
(Cutinase) 		4 ILE A  70
PHE A  36
ARG A  40
THR A  50
 None
 1.29A 5z84N-3qpcA:
undetectable
5z84W-3qpcA:
undetectable		 5z84N-3qpcA:
15.56
5z84W-3qpcA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qyj ALR0039 PROTEIN

(Nostoc sp. PCC
7120) 		PF00561
(Abhydrolase_1) 		4 ILE A 204
PHE A 198
TYR A  34
ARG A 105
 None
 1.28A 5z84N-3qyjA:
undetectable
5z84W-3qyjA:
undetectable		 5z84N-3qyjA:
18.74
5z84W-3qyjA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5k FALCILYSIN

(Plasmodium
falciparum) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		4 ILE A 606
PHE A 609
TYR A 211
THR A 281
 None
 1.24A 5z84N-3s5kA:
1.1
5z84W-3s5kA:
undetectable		 5z84N-3s5kA:
17.08
5z84W-3s5kA:
3.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t24 PORIN

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		4 ILE A 118
PHE A 185
TYR A 211
THR A 167
 None
 1.26A 5z84N-3t24A:
undetectable
5z84W-3t24A:
undetectable		 5z84N-3t24A:
21.66
5z84W-3t24A:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t44 INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE

(Mycobacterium
tuberculosis) 		PF00218
(IGPS) 		4 ILE A 142
PHE A 121
ARG A 191
THR A 195
 None
IGP  A 300 (-4.3A)
BE2  A 273 (-4.5A)
None
 1.23A 5z84N-3t44A:
undetectable
5z84W-3t44A:
undetectable		 5z84N-3t44A:
19.69
5z84W-3t44A:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tkk PREDICTED
ACETAMIDASE/FORMAMID
ASE

(Caldanaerobacter
subterraneus) 		PF03069
(FmdA_AmdA) 		4 ILE A 135
PHE A 169
ARG A 284
THR A 222
 None
 1.12A 5z84N-3tkkA:
undetectable
5z84W-3tkkA:
undetectable		 5z84N-3tkkA:
19.31
5z84W-3tkkA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tnd TRNA(FMET)-SPECIFIC
ENDONUCLEASE VAPC

(Shigella
flexneri) 		PF01850
(PIN) 		4 ILE A  67
PHE A  63
ARG A  25
THR A 114
 None
 1.13A 5z84N-3tndA:
undetectable
5z84W-3tndA:
undetectable		 5z84N-3tndA:
12.12
5z84W-3tndA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u22 PUTATIVE HMUY_LIKE
HEME BINDING PROTEIN

(Bacteroides
vulgatus) 		PF14064
(HmuY) 		4 ILE A  92
PHE A  69
ARG A 196
THR A 211
 None
None
None
GOL  A 315 ( 4.4A)
 1.24A 5z84N-3u22A:
undetectable
5z84W-3u22A:
undetectable		 5z84N-3u22A:
17.72
5z84W-3u22A:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uko ALCOHOL
DEHYDROGENASE
CLASS-3

(Arabidopsis
thaliana) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ILE A 253
PHE A 201
ARG A 315
THR A 306
 None
 1.27A 5z84N-3ukoA:
undetectable
5z84W-3ukoA:
undetectable		 5z84N-3ukoA:
20.92
5z84W-3ukoA:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 ILE A4255
PHE A4252
ARG A4269
THR A4387
 None
 1.21A 5z84N-3vkgA:
undetectable
5z84W-3vkgA:
undetectable		 5z84N-3vkgA:
9.59
5z84W-3vkgA:
1.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wh7 BETA-GLUCOSIDASE

(metagenomes) 		PF00232
(Glyco_hydro_1) 		4 ILE A 417
PHE A 376
TYR A 396
THR A 351
 None
 1.25A 5z84N-3wh7A:
undetectable
5z84W-3wh7A:
undetectable		 5z84N-3wh7A:
21.89
5z84W-3wh7A:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ako SPORE COAT PROTEIN A

(Bacillus
subtilis) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ILE A 412
PHE A 436
ARG A 433
THR A 418
 None
 1.22A 5z84N-4akoA:
undetectable
5z84W-4akoA:
undetectable		 5z84N-4akoA:
21.46
5z84W-4akoA:
7.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eo9 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Mycobacterium
leprae) 		PF00300
(His_Phos_1) 		4 ILE A 182
TYR A 165
ARG A  89
THR A 167
 None
 1.24A 5z84N-4eo9A:
undetectable
5z84W-4eo9A:
undetectable		 5z84N-4eo9A:
18.92
5z84W-4eo9A:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4epi PESTICIN, LYSOZYME
CHIMERA

(Yersinia
pestis;
Escherichia
virus T4) 		PF00959
(Phage_lysozyme) 		4 ILE A  81
PHE A 159
ARG A 139
THR A  95
 None
 1.27A 5z84N-4epiA:
undetectable
5z84W-4epiA:
undetectable		 5z84N-4epiA:
20.60
5z84W-4epiA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgm AMINOPEPTIDASE N
FAMILY PROTEIN

(Idiomarina
loihiensis) 		PF05299
(Peptidase_M61)
PF13180
(PDZ_2) 		4 ILE A 183
PHE A 220
TYR A 275
THR A 210
 None
 0.97A 5z84N-4fgmA:
undetectable
5z84W-4fgmA:
undetectable		 5z84N-4fgmA:
21.18
5z84W-4fgmA:
6.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hz8 BETA-GLUCOSIDASE

(uncultured
bacterium) 		PF00232
(Glyco_hydro_1) 		4 ILE A 452
PHE A 411
TYR A 431
THR A 386
 None
 1.24A 5z84N-4hz8A:
undetectable
5z84W-4hz8A:
undetectable		 5z84N-4hz8A:
22.08
5z84W-4hz8A:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jx0 HYPOTHETICAL PROTEIN

(Bacteroides
fragilis) 		PF08522
(DUF1735) 		4 ILE A 253
PHE A 220
ARG A 265
THR A 268
 None
 1.27A 5z84N-4jx0A:
undetectable
5z84W-4jx0A:
undetectable		 5z84N-4jx0A:
21.01
5z84W-4jx0A:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k46 ADENYLATE KINASE

(Photobacterium
profundum) 		PF00406
(ADK)
PF05191
(ADK_lid) 		4 ILE A  20
PHE A  24
ARG A   2
THR A 191
 None
 1.28A 5z84N-4k46A:
undetectable
5z84W-4k46A:
undetectable		 5z84N-4k46A:
17.21
5z84W-4k46A:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lj2 CHORISMATE SYNTHASE

(Acinetobacter
baumannii) 		PF01264
(Chorismate_synt) 		4 ILE A 140
PHE A  10
ARG A 134
THR A  14
 None
 1.12A 5z84N-4lj2A:
undetectable
5z84W-4lj2A:
undetectable		 5z84N-4lj2A:
21.71
5z84W-4lj2A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m1a HYPOTHETICAL PROTEIN

(Sebaldella
termitidis) 		PF08921
(DUF1904) 		4 ILE A  73
PHE A  77
ARG A   5
THR A  37
 None
 0.83A 5z84N-4m1aA:
undetectable
5z84W-4m1aA:
undetectable		 5z84N-4m1aA:
12.03
5z84W-4m1aA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4me7 MRNA INTERFERASE
ENDOA

(Bacillus
subtilis) 		PF02452
(PemK_toxin) 		4 ILE A  91
PHE A  10
ARG A  70
THR A  47
 None
 1.29A 5z84N-4me7A:
undetectable
5z84W-4me7A:
undetectable		 5z84N-4me7A:
11.89
5z84W-4me7A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mkv RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN

(Pisum sativum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 ILE A 120
PHE A 108
ARG A  83
THR A  31
 None
 1.29A 5z84N-4mkvA:
undetectable
5z84W-4mkvA:
undetectable		 5z84N-4mkvA:
19.63
5z84W-4mkvA:
8.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6g UNCHARACTERIZED
PROTEIN

(Mycobacterium
tuberculosis) 		PF15598
(Imm61) 		4 ILE A  16
PHE A  85
ARG A  44
THR A  57
 None
 1.30A 5z84N-4o6gA:
undetectable
5z84W-4o6gA:
undetectable		 5z84N-4o6gA:
15.84
5z84W-4o6gA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6m AF2299, A
CDP-ALCOHOL
PHOSPHOTRANSFERASE

(Archaeoglobus
fulgidus) 		PF01066
(CDP-OH_P_transf) 		4 ILE A  59
TYR A  12
ARG A  22
THR A  20
 None
 1.28A 5z84N-4o6mA:
1.8
5z84W-4o6mA:
undetectable		 5z84N-4o6mA:
20.87
5z84W-4o6mA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oue PUTATIVE LIPOPROTEIN

(Bacteroides
thetaiotaomicron) 		PF00754
(F5_F8_type_C)
PF01120
(Alpha_L_fucos) 		4 ILE A 405
PHE A 473
ARG A 460
THR A 436
 None
 1.27A 5z84N-4oueA:
undetectable
5z84W-4oueA:
undetectable		 5z84N-4oueA:
18.95
5z84W-4oueA:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qaw XYN30D

(Paenibacillus
barcinonensis) 		PF03422
(CBM_6)
PF17189
(Glyco_hydro_30C) 		4 ILE A 499
PHE A 459
ARG A 511
THR A 509
 None
 1.13A 5z84N-4qawA:
undetectable
5z84W-4qawA:
undetectable		 5z84N-4qawA:
23.40
5z84W-4qawA:
7.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u2m ZINC FINGER AND BTB
DOMAIN-CONTAINING
PROTEIN 17,B-CELL
LYMPHOMA 6 PROTEIN

(Homo sapiens) 		PF00651
(BTB) 		4 ILE A 195
PHE A 184
ARG A 149
THR A 155
 None
 1.25A 5z84N-4u2mA:
undetectable
5z84W-4u2mA:
undetectable		 5z84N-4u2mA:
19.77
5z84W-4u2mA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9s NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT C

(Vibrio cholerae) 		PF04205
(FMN_bind) 		4 ILE C  49
PHE C  67
ARG C  74
THR C 133
 None
GOL  C 302 (-3.4A)
None
None
 1.24A 5z84N-4u9sC:
undetectable
5z84W-4u9sC:
undetectable		 5z84N-4u9sC:
17.51
5z84W-4u9sC:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wql 2''-AMINOGLYCOSIDE
NUCLEOTIDYLTRANSFERA
SE

(Klebsiella
pneumoniae) 		PF10706
(Aminoglyc_resit) 		4 PHE A 133
TYR A 152
ARG A 153
THR A 157
 IPA  A 206 (-4.8A)
IPA  A 206 (-4.0A)
None
None
 1.16A 5z84N-4wqlA:
undetectable
5z84W-4wqlA:
undetectable		 5z84N-4wqlA:
16.87
5z84W-4wqlA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xl1 DELTA-LIKE PROTEIN

(Rattus
norvegicus) 		PF01414
(DSL)
PF07657
(MNNL) 		4 ILE B 140
PHE B  37
ARG B  41
THR B 163
 None
 1.29A 5z84N-4xl1B:
undetectable
5z84W-4xl1B:
undetectable		 5z84N-4xl1B:
17.12
5z84W-4xl1B:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xlw DELTA-LIKE PROTEIN

(Rattus
norvegicus) 		PF01414
(DSL)
PF07657
(MNNL) 		4 ILE B 140
PHE B  37
ARG B  41
THR B 163
 None
 1.26A 5z84N-4xlwB:
undetectable
5z84W-4xlwB:
undetectable		 5z84N-4xlwB:
17.02
5z84W-4xlwB:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yom SERINE/THREONINE-PRO
TEIN KINASE BRSK2

(Mus musculus) 		no annotation 4 ILE A 551
PHE A 555
ARG A 572
THR A 614
 None
 0.99A 5z84N-4yomA:
undetectable
5z84W-4yomA:
undetectable		 5z84N-4yomA:
13.44
5z84W-4yomA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ajh CUTINASE

(Fusarium
oxysporum) 		PF01083
(Cutinase) 		4 ILE A  71
PHE A  37
ARG A  41
THR A  51
 None
 1.27A 5z84N-5ajhA:
undetectable
5z84W-5ajhA:
undetectable		 5z84N-5ajhA:
18.34
5z84W-5ajhA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ay9 4-O-BETA-D-MANNOSYL-
D-GLUCOSE
PHOSPHORYLASE

(Ruminococcus
albus) 		PF04041
(Glyco_hydro_130) 		4 ILE A  44
PHE A 110
ARG A  86
THR A 342
 None
 1.28A 5z84N-5ay9A:
undetectable
5z84W-5ay9A:
undetectable		 5z84N-5ay9A:
20.68
5z84W-5ay9A:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c65 SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 3

(Homo sapiens) 		PF00083
(Sugar_tr) 		4 ILE A 388
PHE A 387
ARG A 454
THR A 333
 None
 0.93A 5z84N-5c65A:
0.6
5z84W-5c65A:
undetectable		 5z84N-5c65A:
24.43
5z84W-5c65A:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgo CELL DIVISION
CONTROL PROTEIN 45
HOMOLOG

(Homo sapiens) 		PF02724
(CDC45) 		4 ILE A 221
PHE A 361
ARG A 247
THR A 240
 None
 1.30A 5z84N-5dgoA:
undetectable
5z84W-5dgoA:
undetectable		 5z84N-5dgoA:
20.69
5z84W-5dgoA:
7.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF17137
(DUF5110) 		4 ILE A 184
PHE A 196
ARG A 109
THR A 107
 None
 1.22A 5z84N-5dkxA:
undetectable
5z84W-5dkxA:
undetectable		 5z84N-5dkxA:
18.91
5z84W-5dkxA:
5.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B

(Neotoma lepida) 		PF00067
(p450) 		4 ILE A 453
PHE A 157
ARG A 308
THR A 175
 None
 1.13A 5z84N-5e0eA:
1.5
5z84W-5e0eA:
undetectable		 5z84N-5e0eA:
21.92
5z84W-5e0eA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5edj FRPC OPERON PROTEIN

(Neisseria
meningitidis) 		PF06901
(FrpC) 		4 ILE A  72
PHE A  63
ARG A  79
THR A  81
 None
 0.85A 5z84N-5edjA:
undetectable
5z84W-5edjA:
undetectable		 5z84N-5edjA:
16.42
5z84W-5edjA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5edj FRPC OPERON PROTEIN

(Neisseria
meningitidis) 		PF06901
(FrpC) 		4 ILE A  72
PHE A  63
TYR A  80
ARG A  79
 None
 1.31A 5z84N-5edjA:
undetectable
5z84W-5edjA:
undetectable		 5z84N-5edjA:
16.42
5z84W-5edjA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5efv PHI ETA ORF 56-LIKE
PROTEIN

(Staphylococcus
virus 11) 		no annotation 4 ILE A 224
PHE A 240
TYR A 187
THR A 211
 None
 1.26A 5z84N-5efvA:
undetectable
5z84W-5efvA:
undetectable		 5z84N-5efvA:
20.24
5z84W-5efvA:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7c ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 ILE A  76
TYR A 304
ARG A 299
THR A 302
 None
 1.05A 5z84N-5f7cA:
undetectable
5z84W-5f7cA:
undetectable		 5z84N-5f7cA:
21.92
5z84W-5f7cA:
6.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ghs SSDNA-SPECIFIC
EXONUCLEASE

(Thermococcus
kodakarensis) 		PF02272
(DHHA1) 		4 PHE A  98
TYR A  79
ARG A  28
THR A  26
 None
 1.08A 5z84N-5ghsA:
undetectable
5z84W-5ghsA:
undetectable		 5z84N-5ghsA:
19.85
5z84W-5ghsA:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iri SERINE/THREONINE-PRO
TEIN KINASE BRSK1

(Mus musculus) 		no annotation 4 ILE A 624
PHE A 628
ARG A 645
THR A 693
 None
 1.03A 5z84N-5iriA:
undetectable
5z84W-5iriA:
undetectable		 5z84N-5iriA:
12.23
5z84W-5iriA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbp GLYCOSYL HYDROLASE,
FAMILY 38

(Enterococcus
faecalis) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		4 ILE A 662
PHE A 641
ARG A 672
THR A 558
 None
 1.30A 5z84N-5kbpA:
2.9
5z84W-5kbpA:
undetectable		 5z84N-5kbpA:
19.96
5z84W-5kbpA:
5.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqm GLYCOSYL HYDROLASES
FAMILY 2, SUGAR
BINDING DOMAIN

(Bacteroides
thetaiotaomicron) 		PF17132
(Glyco_hydro_106) 		4 ILE A 981
PHE A 971
TYR A 990
THR A1054
 None
 1.21A 5z84N-5mqmA:
undetectable
5z84W-5mqmA:
undetectable		 5z84N-5mqmA:
19.15
5z84W-5mqmA:
4.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n1x B-CELL LYMPHOMA 6
PROTEIN

(Homo sapiens) 		PF00651
(BTB) 		4 ILE D  72
PHE D  61
ARG D  26
THR D  32
 None
 1.30A 5z84N-5n1xD:
undetectable
5z84W-5n1xD:
undetectable		 5z84N-5n1xD:
14.18
5z84W-5n1xD:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis) 		no annotation 4 ILE A 371
PHE A 404
ARG A 414
THR A 367
 None
 1.19A 5z84N-5ot1A:
undetectable
5z84W-5ot1A:
undetectable		 5z84N-5ot1A:
undetectable
5z84W-5ot1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oyn DEHYDRATASE,
ILVD/EDD FAMILY

(Caulobacter
vibrioides) 		no annotation 4 ILE A 498
PHE A 390
ARG A 521
THR A 526
 None
 1.12A 5z84N-5oynA:
undetectable
5z84W-5oynA:
undetectable		 5z84N-5oynA:
undetectable
5z84W-5oynA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ts5 AMINE OXIDASE

(Bothrops atrox) 		PF01593
(Amino_oxidase) 		4 ILE A 264
PHE A 304
ARG A 301
THR A 295
 None
None
None
FAD  A 501 (-4.6A)
 1.10A 5z84N-5ts5A:
undetectable
5z84W-5ts5A:
undetectable		 5z84N-5ts5A:
21.14
5z84W-5ts5A:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wyp DNA POLYMERASE III
SUBUNIT BETA

(Caulobacter
vibrioides) 		no annotation 4 ILE A 323
PHE A 321
ARG A 345
THR A 263
 None
 1.04A 5z84N-5wypA:
undetectable
5z84W-5wypA:
undetectable		 5z84N-5wypA:
undetectable
5z84W-5wypA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9o B-CELL LYMPHOMA 6
PROTEIN

(Homo sapiens) 		PF00651
(BTB) 		4 ILE A  72
PHE A  61
ARG A  26
THR A  32
 None
 1.28A 5z84N-5x9oA:
undetectable
5z84W-5x9oA:
undetectable		 5z84N-5x9oA:
13.68
5z84W-5x9oA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xex POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Staphylococcus
aureus) 		no annotation 4 ILE A 523
PHE A 497
ARG A 531
THR A 197
 None
 1.23A 5z84N-5xexA:
undetectable
5z84W-5xexA:
undetectable		 5z84N-5xexA:
21.93
5z84W-5xexA:
6.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xzq HYDROXYNITRILE LYASE

(Passiflora
edulis) 		no annotation 4 ILE A  26
PHE A  90
TYR A  64
THR A  47
 None
 1.24A 5z84N-5xzqA:
undetectable
5z84W-5xzqA:
undetectable		 5z84N-5xzqA:
13.23
5z84W-5xzqA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yy3 -

(-) 		no annotation 4 ILE A 626
PHE A 566
ARG A 590
THR A 480
 None
 1.27A 5z84N-5yy3A:
undetectable
5z84W-5yy3A:
undetectable		 5z84N-5yy3A:
undetectable
5z84W-5yy3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z2g L-AMINO ACID OXIDASE

(Naja atra) 		no annotation 4 ILE A 283
PHE A 321
ARG A 318
THR A 312
 None
None
None
FAD  A 604 (-4.4A)
 1.06A 5z84N-5z2gA:
undetectable
5z84W-5z2gA:
undetectable		 5z84N-5z2gA:
undetectable
5z84W-5z2gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3x CLEAVAGE STIMULATION
FACTOR SUBUNIT 1

(Homo sapiens) 		no annotation 4 ILE A  81
PHE A 361
TYR A 344
THR A 340
 None
 1.22A 5z84N-6b3xA:
undetectable
5z84W-6b3xA:
undetectable		 5z84N-6b3xA:
20.59
5z84W-6b3xA:
8.88