SIMILAR PATTERNS OF AMINO ACIDS FOR 5Z84_J_CHDJ101_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bih HEMOLIN

(Hyalophora
cecropia) 		PF07679
(I-set)
PF13927
(Ig_3) 		3 TYR A 246
ARG A 263
THR A 262
 None
 0.93A 5z84J-1bihA:
0.0		 5z84J-1bihA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cjy PROTEIN (CYTOSOLIC
PHOSPHOLIPASE A2)

(Homo sapiens) 		PF00168
(C2)
PF01735
(PLA2_B) 		3 TYR A 275
ARG A 274
THR A 268
 None
 0.97A 5z84J-1cjyA:
0.0		 5z84J-1cjyA:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1h BOTULINUM NEUROTOXIN
TYPE A LIGHT CHAIN

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		3 TYR A  98
ARG A 104
THR A 108
 None
 1.02A 5z84J-1e1hA:
0.0		 5z84J-1e1hA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II

(Saccharomyces
cerevisiae) 		PF00150
(Cellulase) 		3 TYR A 439
ARG A 390
THR A 389
 None
 0.85A 5z84J-1h4pA:
0.0		 5z84J-1h4pA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3e SEQA PROTEIN

(Escherichia
coli) 		PF03925
(SeqA) 		3 TYR A  55
ARG A  53
THR A  52
 None
 1.01A 5z84J-1j3eA:
0.0		 5z84J-1j3eA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqg CARBOXYPEPTIDASE A

(Helicoverpa
armigera) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		3 TYR A 125
ARG A  71
THR A 119
 None
 0.92A 5z84J-1jqgA:
0.0		 5z84J-1jqgA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5j ACONITATE HYDRATASE
2

(Escherichia
coli) 		PF00330
(Aconitase)
PF06434
(Aconitase_2_N)
PF11791
(Aconitase_B_N) 		3 TYR A 841
ARG A 718
THR A 836
 None
 0.97A 5z84J-1l5jA:
0.0		 5z84J-1l5jA:
4.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r5j PUTATIVE
PHOSPHOTRANSACETYLAS
E

(Streptococcus
pyogenes) 		PF01515
(PTA_PTB) 		3 TYR A  69
ARG A  56
THR A  60
 None
 1.03A 5z84J-1r5jA:
0.0		 5z84J-1r5jA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rw0 CONSERVED
HYPOTHETICAL PROTEIN

(Salmonella
enterica) 		PF02578
(Cu-oxidase_4) 		3 TYR A  92
ARG A  77
THR A  79
 None
 0.77A 5z84J-1rw0A:
0.0		 5z84J-1rw0A:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B

(Homo sapiens) 		PF00233
(PDEase_I) 		3 TYR A 731
ARG A 739
THR A 743
 None
 0.80A 5z84J-1sojA:
undetectable		 5z84J-1sojA:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w93 ACETYL-COENZYME A
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		3 TYR A 308
ARG A  24
THR A  26
 None
 0.97A 5z84J-1w93A:
undetectable		 5z84J-1w93A:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wom SIGMA FACTOR SIGB
REGULATION PROTEIN
RSBQ

(Bacillus
subtilis) 		PF12697
(Abhydrolase_6) 		3 TYR A  74
ARG A  67
THR A  70
 None
 0.92A 5z84J-1womA:
undetectable		 5z84J-1womA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xer FERREDOXIN

(Sulfurisphaera
tokodaii) 		PF13187
(Fer4_9) 		3 TYR A  22
ARG A   7
THR A   8
 None
 1.04A 5z84J-1xerA:
undetectable		 5z84J-1xerA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zhn CD1D1 ANTIGEN

(Mus musculus) 		PF07654
(C1-set)
PF16497
(MHC_I_3) 		3 TYR A  73
ARG A  74
THR A  78
 PC6  A   1 (-3.9A)
None
None
 0.97A 5z84J-1zhnA:
undetectable		 5z84J-1zhnA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cn3 BETA-1,4-XYLOGLUCAN
HYDROLASE

(Ruminiclostridium
thermocellum) 		PF02012
(BNR) 		3 TYR A 115
ARG A 134
THR A 136
 None
 0.81A 5z84J-2cn3A:
undetectable		 5z84J-2cn3A:
7.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B

(Staphylococcus
aureus;
Staphylococcus
aureus) 		PF01425
(Amidase)
PF02637
(GatB_Yqey)
PF02934
(GatB_N) 		3 TYR B  44
ARG A 328
THR B  37
 None
 0.89A 5z84J-2f2aB:
undetectable		 5z84J-2f2aB:
7.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fez PROBABLE REGULATORY
PROTEIN EMBR

(Mycobacterium
tuberculosis) 		PF00486
(Trans_reg_C)
PF00498
(FHA)
PF03704
(BTAD) 		3 TYR A 228
ARG A 229
THR A 233
 None
 0.91A 5z84J-2fezA:
undetectable		 5z84J-2fezA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hcs RNA-DIRECTED RNA
POLYMERASE (NS5)

(West Nile virus) 		PF00972
(Flavi_NS5) 		3 TYR A 771
ARG A 774
THR A 731
 None
 0.97A 5z84J-2hcsA:
undetectable		 5z84J-2hcsA:
7.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ixn SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
ACTIVATOR 2

(Saccharomyces
cerevisiae) 		PF03095
(PTPA) 		3 TYR A 196
ARG A 174
THR A 178
 None
 0.97A 5z84J-2ixnA:
undetectable		 5z84J-2ixnA:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nml ENHANCER OF
RUDIMENTARY HOMOLOG

(Homo sapiens) 		PF01133
(ER) 		3 TYR A  72
ARG A  73
THR A  76
 None
 0.98A 5z84J-2nmlA:
undetectable		 5z84J-2nmlA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oqc PENICILLIN V ACYLASE

(Bacillus
subtilis) 		PF02275
(CBAH) 		3 TYR A  52
ARG A  34
THR A  50
 None
 0.97A 5z84J-2oqcA:
undetectable		 5z84J-2oqcA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2py6 METHYLTRANSFERASE
FKBM

(Methylobacillus
flagellatus) 		PF05050
(Methyltransf_21) 		3 TYR A 406
ARG A 394
THR A 213
 None
 0.87A 5z84J-2py6A:
undetectable		 5z84J-2py6A:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qf7 PYRUVATE CARBOXYLASE
PROTEIN

(Rhizobium etli) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		3 TYR A 452
ARG A 215
THR A 454
 None
None
AGS  A1162 (-3.5A)
 0.80A 5z84J-2qf7A:
undetectable		 5z84J-2qf7A:
5.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qr6 IMP
DEHYDROGENASE/GMP
REDUCTASE

(Corynebacterium
glutamicum) 		PF00478
(IMPDH) 		3 TYR A 250
ARG A 211
THR A 212
 None
 0.96A 5z84J-2qr6A:
undetectable		 5z84J-2qr6A:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r8a LONG-CHAIN FATTY
ACID TRANSPORT
PROTEIN

(Escherichia
coli) 		PF03349
(Toluene_X) 		3 TYR A 227
ARG A 228
THR A 296
 None
 0.77A 5z84J-2r8aA:
undetectable		 5z84J-2r8aA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9u VARIABLE LYMPHOCYTE
RECEPTOR

(Petromyzon
marinus) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		3 TYR A 142
ARG A 114
THR A  90
 None
 0.67A 5z84J-2r9uA:
undetectable		 5z84J-2r9uA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vy0 ENDO-BETA-1,3-GLUCAN
ASE

(Pyrococcus
furiosus) 		PF00722
(Glyco_hydro_16) 		3 TYR A 237
ARG A 201
THR A 204
 None
 0.96A 5z84J-2vy0A:
undetectable		 5z84J-2vy0A:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsk GLYCOGEN DEBRANCHING
ENZYME

(Escherichia
coli) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		3 TYR A 163
ARG A 173
THR A 175
 None
 1.04A 5z84J-2wskA:
undetectable		 5z84J-2wskA:
6.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x05 EXO-BETA-D-GLUCOSAMI
NIDASE

(Amycolatopsis
orientalis) 		PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N) 		3 TYR A 349
ARG A 347
THR A 637
 None
 0.97A 5z84J-2x05A:
undetectable		 5z84J-2x05A:
4.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ail 303AA LONG
HYPOTHETICAL
ESTERASE

(Sulfurisphaera
tokodaii) 		PF07859
(Abhydrolase_3) 		3 TYR A 301
ARG A 297
THR A  66
 None
 0.98A 5z84J-3ailA:
undetectable		 5z84J-3ailA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b89 16S RRNA METHYLASE

(Escherichia
coli) 		PF07091
(FmrO) 		3 TYR A  16
ARG A  46
THR A  47
 None
 0.95A 5z84J-3b89A:
undetectable		 5z84J-3b89A:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3di5 DINB-LIKE PROTEIN

(Bacillus cereus) 		PF05163
(DinB) 		3 TYR A  84
ARG A  85
THR A  89
 None
 1.01A 5z84J-3di5A:
undetectable		 5z84J-3di5A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb7 INSECTICIDAL
DELTA-ENDOTOXIN
CRY8EA1

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		3 TYR A 249
ARG A 250
THR A 251
 None
 1.03A 5z84J-3eb7A:
undetectable		 5z84J-3eb7A:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g01 GRANZYME C

(Mus musculus) 		PF00089
(Trypsin) 		3 TYR A 220
ARG A 106
THR A 232
 None
 0.87A 5z84J-3g01A:
undetectable		 5z84J-3g01A:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4i GLYCOSYLTRANSFERASE
GTFA,
GLYCOSYLTRANSFERASE

(Actinoplanes
teichomyceticus;
Amycolatopsis
orientalis) 		PF03033
(Glyco_transf_28)
PF04101
(Glyco_tran_28_C) 		3 TYR A 119
ARG A 120
THR A 122
 None
SO4  A 601 (-2.9A)
None
 0.98A 5z84J-3h4iA:
undetectable		 5z84J-3h4iA:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzj RAB
GTPASE-ACTIVATING
PROTEIN 1-LIKE

(Homo sapiens) 		PF00566
(RabGAP-TBC) 		3 TYR A 564
ARG A 565
THR A 569
 None
UNX  A 906 ( 4.3A)
None
 1.03A 5z84J-3hzjA:
undetectable		 5z84J-3hzjA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzr TRYPTOPHANYL-TRNA
SYNTHETASE

(Entamoeba
histolytica) 		PF00579
(tRNA-synt_1b) 		3 TYR A 166
ARG A 167
THR A 168
 None
 1.05A 5z84J-3hzrA:
undetectable		 5z84J-3hzrA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i27 HEMAGGLUTININ-ESTERA
SE

(Bovine
torovirus) 		PF02710
(Hema_HEFG)
PF03996
(Hema_esterase) 		3 TYR A 248
ARG A 122
THR A 121
 None
 1.02A 5z84J-3i27A:
undetectable		 5z84J-3i27A:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i27 HEMAGGLUTININ-ESTERA
SE

(Bovine
torovirus) 		PF02710
(Hema_HEFG)
PF03996
(Hema_esterase) 		3 TYR A 248
ARG A 122
THR A 125
 None
 0.81A 5z84J-3i27A:
undetectable		 5z84J-3i27A:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
PRE-MRNA-SPLICING
FACTOR CWF19

(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe) 		PF08082
(PRO8NT)
PF08083
(PROCN)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV)
no annotation 		3 TYR A1810
ARG c 432
THR A1824
 None
 0.97A 5z84J-3jb9A:
undetectable		 5z84J-3jb9A:
2.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4z GLYCOSIDE HYDROLASE
FAMILY 9

(Ruminiclostridium
thermocellum) 		PF02018
(CBM_4_9)
PF02927
(CelD_N) 		3 TYR A 171
ARG A  86
THR A  84
 None
 0.99A 5z84J-3k4zA:
undetectable		 5z84J-3k4zA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6q PUTATIVE LIGAND
BINDING PROTEIN

(Syntrophomonas
wolfei) 		PF12910
(PHD_like) 		3 TYR A  97
ARG A 110
THR A 112
 None
 0.90A 5z84J-3k6qA:
undetectable		 5z84J-3k6qA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kdw PUTATIVE SUGAR
BINDING PROTEIN

(Bacteroides
vulgatus) 		PF12875
(DUF3826) 		3 TYR A 109
ARG A 110
THR A 111
 None
 1.02A 5z84J-3kdwA:
undetectable		 5z84J-3kdwA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kt4 PKHD-TYPE
HYDROXYLASE TPA1

(Saccharomyces
cerevisiae) 		PF10637
(Ofd1_CTDD)
PF13661
(2OG-FeII_Oxy_4) 		3 TYR A 245
ARG A 126
THR A 143
 None
 1.04A 5z84J-3kt4A:
undetectable		 5z84J-3kt4A:
7.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ljb INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1

(Homo sapiens) 		PF01031
(Dynamin_M)
PF02212
(GED) 		3 TYR A 451
ARG A 452
THR A 456
 None
 0.77A 5z84J-3ljbA:
undetectable		 5z84J-3ljbA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lrv PRE-MRNA-SPLICING
FACTOR 19

(Saccharomyces
cerevisiae) 		no annotation 3 TYR A 333
ARG A 308
THR A 310
 None
 0.79A 5z84J-3lrvA:
undetectable		 5z84J-3lrvA:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ojd FAB V2D2

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 TYR B  27
ARG B  76
THR B  30
 None
 0.73A 5z84J-3ojdB:
undetectable		 5z84J-3ojdB:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pl2 SUGAR KINASE,
RIBOKINASE FAMILY

(Corynebacterium
glutamicum) 		PF00294
(PfkB) 		3 TYR A 173
ARG A 174
THR A 143
 None
 1.02A 5z84J-3pl2A:
undetectable		 5z84J-3pl2A:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r0v ALPHA/BETA HYDROLASE
FOLD PROTEIN

(Sphaerobacter
thermophilus) 		PF12697
(Abhydrolase_6) 		3 TYR A  66
ARG A  55
THR A 181
 None
 0.77A 5z84J-3r0vA:
undetectable		 5z84J-3r0vA:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r5y PUTATIVE
UNCHARACTERIZED
PROTEIN

(Nocardia
farcinica) 		PF04075
(F420H2_quin_red) 		3 TYR A   9
ARG A  54
THR A  56
 None
F42  A 147 (-3.6A)
F42  A 147 (-4.0A)
 1.01A 5z84J-3r5yA:
undetectable		 5z84J-3r5yA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6k ACETYLGLUTAMATE
KINASE

(Xanthomonas
campestris) 		PF00696
(AA_kinase)
PF04768
(NAT) 		3 TYR A 337
ARG A 299
THR A 301
 None
 0.84A 5z84J-3s6kA:
undetectable		 5z84J-3s6kA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3te7 RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE]

(Homo sapiens) 		PF02525
(Flavodoxin_2) 		3 TYR A  75
ARG A  78
THR A  85
 None
 1.05A 5z84J-3te7A:
undetectable		 5z84J-3te7A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tgw V-TYPE ATP SYNTHASE
BETA CHAIN

(Methanosarcina
mazei) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		3 TYR A 252
ARG A 220
THR A 223
 None
 0.91A 5z84J-3tgwA:
undetectable		 5z84J-3tgwA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tt1 MOUSE MONOCLONAL
1GG2A FAB FRAGMENT,
KAPPA LIGHT CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 TYR H  27
ARG H  77
THR H  30
 None
 0.82A 5z84J-3tt1H:
undetectable		 5z84J-3tt1H:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfz LACTO-N-BIOSE
PHOSPHORYLASE

(Bifidobacterium
longum) 		PF09508
(Lact_bio_phlase)
PF17385
(LBP_M)
PF17386
(LBP_C) 		3 TYR A 399
ARG A 358
THR A   8
 None
 0.96A 5z84J-3wfzA:
undetectable		 5z84J-3wfzA:
5.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a1g MITOTIC CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1

(Homo sapiens) 		PF08311
(Mad3_BUB1_I) 		3 TYR A 140
ARG A 141
THR A 145
 None
 0.86A 5z84J-4a1gA:
undetectable		 5z84J-4a1gA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bz2 FAB 2D73 HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 TYR H  27
ARG H  77
THR H  30
 None
GOL  H 228 (-3.3A)
None
 0.64A 5z84J-4bz2H:
undetectable		 5z84J-4bz2H:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4en8 HEMAGGLUTININ
COMPONENTS
HA-22/23/53

(Clostridium
botulinum) 		PF03505
(Clenterotox) 		3 TYR B 536
ARG B 525
THR B 508
 None
SIA  B 701 (-3.0A)
None
 0.73A 5z84J-4en8B:
undetectable		 5z84J-4en8B:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f9l 20.1 ANTI-BTN3A1
ANTIBODY FRAGMENT

(Mus musculus) 		no annotation 3 TYR D 158
ARG D 208
THR D 161
 None
 0.80A 5z84J-4f9lD:
undetectable		 5z84J-4f9lD:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hte NICKING ENZYME

(Staphylococcus
aureus) 		no annotation 3 TYR A 517
ARG A 522
THR A 526
 None
 0.94A 5z84J-4hteA:
undetectable		 5z84J-4hteA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jon CENTROSOMAL PROTEIN
OF 170 KDA

(Homo sapiens) 		PF00498
(FHA) 		3 TYR A  91
ARG A  88
THR A  66
 None
 0.93A 5z84J-4jonA:
undetectable		 5z84J-4jonA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k24 ANTI-UPAR ANTIBODY,
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 TYR H  27
ARG H  76
THR H  30
 None
 0.93A 5z84J-4k24H:
undetectable		 5z84J-4k24H:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ljs PERIPLASMIC BINDING
PROTEIN

(Veillonella
parvula) 		PF01497
(Peripla_BP_2) 		3 TYR A  99
ARG A 314
THR A  73
 None
 0.68A 5z84J-4ljsA:
undetectable		 5z84J-4ljsA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nm4 ANTIBODY CR8043,
HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 TYR H  27
ARG H  76
THR H  30
 None
 0.81A 5z84J-4nm4H:
undetectable		 5z84J-4nm4H:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oiv BILE ACID RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		3 TYR A 386
ARG A 335
THR A 390
 None
 1.02A 5z84J-4oivA:
undetectable		 5z84J-4oivA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ony EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 5

(Brucella
melitensis) 		PF00496
(SBP_bac_5) 		3 TYR A 482
ARG A 476
THR A 479
 None
 0.97A 5z84J-4onyA:
undetectable		 5z84J-4onyA:
7.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4py9 PUTATIVE
EXOPOLYPHOSPHATASE-R
ELATED PROTEIN

(Bacteroides
fragilis) 		PF01368
(DHH) 		3 TYR A 208
ARG A 209
THR A 214
 None
 1.03A 5z84J-4py9A:
undetectable		 5z84J-4py9A:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qnw CHANOCLAVINE-I
ALDEHYDE REDUCTASE

(Aspergillus
fumigatus) 		PF00724
(Oxidored_FMN) 		3 TYR A 359
ARG A  52
THR A  30
 None
None
FMN  A 401 (-4.5A)
 0.97A 5z84J-4qnwA:
undetectable		 5z84J-4qnwA:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgm 20B1 HEAVY CHAIN

(Mus musculus) 		no annotation 3 TYR H  27
ARG H  77
THR H  30
 None
 0.83A 5z84J-4rgmH:
undetectable		 5z84J-4rgmH:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rtb HYDG PROTEIN

(Carboxydothermus
hydrogenoformans) 		PF04055
(Radical_SAM)
PF06968
(BATS) 		3 TYR A 335
ARG A 329
THR A 330
 None
 0.99A 5z84J-4rtbA:
undetectable		 5z84J-4rtbA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wy8 ESTERASE

(Rhizomucor
miehei) 		PF07859
(Abhydrolase_3) 		3 TYR A 204
ARG A 215
THR A 214
 None
 1.01A 5z84J-4wy8A:
undetectable		 5z84J-4wy8A:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ydo UNCHARACTERIZED
PROTEIN

(Candida
albicans) 		PF00432
(Prenyltrans) 		3 TYR B 433
ARG B 413
THR B 372
 None
 1.04A 5z84J-4ydoB:
undetectable		 5z84J-4ydoB:
7.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yyf BETA-N-ACETYLHEXOSAM
INIDASE

(Mycolicibacterium
smegmatis) 		PF00933
(Glyco_hydro_3) 		3 TYR A 300
ARG A 259
THR A 260
 None
 0.97A 5z84J-4yyfA:
undetectable		 5z84J-4yyfA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a96 POLYHEDRIN

(Cypovirus 14) 		PF17515
(CPV_Polyhedrin) 		3 TYR A  78
ARG A  79
THR A  83
 None
 1.04A 5z84J-5a96A:
undetectable		 5z84J-5a96A:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d91 AF2299
PROTEIN,PHOSPHATIDYL
INOSITOL SYNTHASE

(Renibacterium
salmoninarum;
Archaeoglobus
fulgidus) 		PF01066
(CDP-OH_P_transf) 		3 TYR A-119
ARG A-109
THR A-111
 None
 1.01A 5z84J-5d91A:
undetectable		 5z84J-5d91A:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ewo STRUCTURAL PROTEIN

(Mamastrovirus 1) 		PF12226
(Astro_capsid_p) 		3 TYR A 557
ARG A 572
THR A 613
 None
 0.92A 5z84J-5ewoA:
undetectable		 5z84J-5ewoA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exr DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1)
PF08996
(zf-DNA_Pol) 		3 TYR C 349
ARG C 682
THR C 685
 None
 1.04A 5z84J-5exrC:
undetectable		 5z84J-5exrC:
4.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C

(Homo sapiens) 		PF00856
(SET) 		3 TYR A4762
ARG A4763
THR A4767
 None
 0.70A 5z84J-5f59A:
undetectable		 5z84J-5f59A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7c ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		3 TYR A 304
ARG A 299
THR A 302
 None
 0.73A 5z84J-5f7cA:
undetectable		 5z84J-5f7cA:
6.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fkr ENDO-1,4-BETA-GLUCAN
ASE/XYLOGLUCANASE,
PUTATIVE, GLY74A

(Cellvibrio
japonicus) 		no annotation 3 TYR A 115
ARG A 134
THR A 136
 None
 0.91A 5z84J-5fkrA:
undetectable		 5z84J-5fkrA:
6.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g56 CARBOHYDRATE BINDING
FAMILY 6

(Ruminiclostridium
thermocellum) 		PF00150
(Cellulase)
PF03422
(CBM_6) 		3 TYR A 197
ARG A 198
THR A 202
 None
 0.72A 5z84J-5g56A:
undetectable		 5z84J-5g56A:
4.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gai PORTAL PROTEIN

(Salmonella
virus P22) 		PF16510
(P22_portal) 		3 TYR A  98
ARG A  99
THR A 100
 None
 1.02A 5z84J-5gaiA:
undetectable		 5z84J-5gaiA:
6.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ghs SSDNA-SPECIFIC
EXONUCLEASE

(Thermococcus
kodakarensis) 		PF02272
(DHHA1) 		3 TYR A  79
ARG A  28
THR A  26
 None
 0.97A 5z84J-5ghsA:
undetectable		 5z84J-5ghsA:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gjw VOLTAGE-DEPENDENT
CALCIUM CHANNEL
SUBUNIT
ALPHA-2/DELTA-1

(Oryctolagus
cuniculus) 		PF00092
(VWA)
PF08399
(VWA_N)
PF08473
(VGCC_alpha2) 		3 TYR F 609
ARG F 607
THR F 589
 None
 1.00A 5z84J-5gjwF:
undetectable		 5z84J-5gjwF:
4.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gtm INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1

(Homo sapiens) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
PF02212
(GED) 		3 TYR A 451
ARG A 452
THR A 456
 None
 0.86A 5z84J-5gtmA:
undetectable		 5z84J-5gtmA:
6.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k04 UNCHARACTERIZED
PROTEIN

(Candida
albicans) 		PF09797
(NatB_MDM20) 		3 TYR A 461
ARG A 462
THR A 466
 None
 0.79A 5z84J-5k04A:
undetectable		 5z84J-5k04A:
7.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9s ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (MANNOPINE)

(Agrobacterium
fabrum) 		PF13416
(SBP_bac_8) 		3 TYR A  96
ARG A  79
THR A  83
 None
 0.77A 5z84J-5l9sA:
undetectable		 5z84J-5l9sA:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5la0 CARBOHYDRATE BINDING
FAMILY 6

(Ruminiclostridium
thermocellum) 		PF00150
(Cellulase)
PF03422
(CBM_6) 		3 TYR A 197
ARG A 198
THR A 202
 None
 0.69A 5z84J-5la0A:
undetectable		 5z84J-5la0A:
6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5med ARACHIDONATE
15-LIPOXYGENASE

(Cyanothece sp.
PCC 8801) 		PF00305
(Lipoxygenase) 		3 TYR A 333
ARG A 260
THR A 261
 None
BU1  A1004 (-3.7A)
None
 0.91A 5z84J-5medA:
undetectable		 5z84J-5medA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ofb MORC FAMILY CW-TYPE
ZINC FINGER PROTEIN
2

(Homo sapiens) 		no annotation 3 TYR B 394
ARG B 237
THR B 233
 None
 0.73A 5z84J-5ofbB:
undetectable		 5z84J-5ofbB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opj RHAMNOGALACTURONAN
LYASE

(Bacteroides
thetaiotaomicron) 		no annotation 3 TYR A 798
ARG A 709
THR A 705
 None
 0.92A 5z84J-5opjA:
undetectable		 5z84J-5opjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t7c HIPPOCALCIN-LIKE
PROTEIN 1

(Homo sapiens) 		PF13499
(EF-hand_7)
PF13833
(EF-hand_8) 		3 TYR A 129
ARG A 148
THR A 144
 None
 0.93A 5z84J-5t7cA:
undetectable		 5z84J-5t7cA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5voc ENVELOPE
GLYCOPROTEIN H

(Human
betaherpesvirus
5) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		3 TYR A 135
ARG A 270
THR A 272
 None
 1.02A 5z84J-5vocA:
undetectable		 5z84J-5vocA:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wea PROTEIN ARGONAUTE-2

(Homo sapiens) 		no annotation 3 TYR A 857
ARG A 812
THR A 538
 None
A  B   1 ( 3.5A)
None
 0.90A 5z84J-5weaA:
undetectable		 5z84J-5weaA:
7.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wzr ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Bifidobacterium
bifidum) 		PF11308
(Glyco_hydro_129) 		3 TYR A 217
ARG A 455
THR A 453
 None
 1.03A 5z84J-5wzrA:
undetectable		 5z84J-5wzrA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6x MRNA CAPPING ENZYME
P5

(Rice dwarf
virus) 		no annotation 3 TYR C  73
ARG C  74
THR C  78
 None
 0.71A 5z84J-5x6xC:
undetectable		 5z84J-5x6xC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c5w NANOBODY

(Escherichia
coli) 		no annotation 3 TYR C  33
ARG C  71
THR C  57
 None
 0.70A 5z84J-6c5wC:
undetectable		 5z84J-6c5wC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d2v TERB OXIDOREDUCTASE

(Streptomyces) 		no annotation 3 TYR A  64
ARG A 100
THR A 103
 None
None
SCN  A 402 ( 4.1A)
 1.03A 5z84J-6d2vA:
undetectable		 5z84J-6d2vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dxo RNA POLYMERASE
ECF-SUBFAMILY SIGMA
FACTOR

(Streptomyces
venezuelae) 		no annotation 3 TYR A 162
ARG A 163
THR A 167
 None
 0.73A 5z84J-6dxoA:
undetectable		 5z84J-6dxoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
6
NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
9, MITOCHONDRIAL

(Mus musculus;
Mus musculus) 		no annotation
no annotation 		3 TYR J  78
ARG P 325
THR P 323
 None
 1.04A 5z84J-6g2jJ:
undetectable		 5z84J-6g2jJ:
undetectable