SIMILAR PATTERNS OF AMINO ACIDS FOR 5Z84_C_CHDC307

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1914 SIGNAL RECOGNITION
PARTICLE 9/14 FUSION
PROTEIN

(Mus musculus) 		PF02290
(SRP14)
PF05486
(SRP9-21) 		4 LEU A2086
PHE A2017
LEU A2013
PHE A2009
 None
 0.90A 5z84C-1914A:
0.7
5z84J-1914A:
0.0		 5z84C-1914A:
19.40
5z84J-1914A:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1agx GLUTAMINASE-ASPARAGI
NASE

(Acinetobacter
glutaminasificans) 		PF00710
(Asparaginase) 		4 LEU A 313
PHE A 205
LEU A 104
PHE A 100
 None
 0.84A 5z84C-1agxA:
undetectable
5z84J-1agxA:
0.0		 5z84C-1agxA:
21.25
5z84J-1agxA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj3 ADENYLOSUCCINATE
SYNTHETASE

(Triticum
aestivum) 		PF00709
(Adenylsucc_synt) 		4 LEU A 164
PHE A 175
LEU A 179
PHE A 183
 None
 0.63A 5z84C-1dj3A:
undetectable
5z84J-1dj3A:
0.0		 5z84C-1dj3A:
19.00
5z84J-1dj3A:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj3 ADENYLOSUCCINATE
SYNTHETASE

(Triticum
aestivum) 		PF00709
(Adenylsucc_synt) 		4 LEU A 200
PHE A 183
LEU A 179
PHE A 175
 None
 0.77A 5z84C-1dj3A:
undetectable
5z84J-1dj3A:
0.0		 5z84C-1dj3A:
19.00
5z84J-1dj3A:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ipk BETA-CONGLYCININ,
BETA CHAIN

(Glycine max) 		PF00190
(Cupin_1)
PF07883
(Cupin_2) 		4 LEU A 244
PHE A 217
LEU A 251
PHE A 338
 None
 0.95A 5z84C-1ipkA:
undetectable
5z84J-1ipkA:
0.0		 5z84C-1ipkA:
18.72
5z84J-1ipkA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ji6 PESTICIDIAL CRYSTAL
PROTEIN CRY3BB

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 LEU A 137
GLN A 138
PHE A 141
PHE A 178
 None
 0.89A 5z84C-1ji6A:
2.9
5z84J-1ji6A:
0.0		 5z84C-1ji6A:
19.52
5z84J-1ji6A:
7.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jkw CYCLIN H

(Homo sapiens) 		PF00134
(Cyclin_N)
PF16899
(Cyclin_C_2) 		4 ARG A 102
LEU A 106
PHE A 110
LEU A 129
 None
 0.86A 5z84C-1jkwA:
0.7
5z84J-1jkwA:
0.0		 5z84C-1jkwA:
20.52
5z84J-1jkwA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js6 DOPA DECARBOXYLASE

(Sus scrofa) 		PF00282
(Pyridoxal_deC) 		4 LEU A 114
PHE A 357
LEU A 360
PHE A 364
 None
 0.89A 5z84C-1js6A:
0.0
5z84J-1js6A:
0.0		 5z84C-1js6A:
19.84
5z84J-1js6A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kkc MANGANESE SUPEROXIDE
DISMUTASE

(Aspergillus
fumigatus) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 LEU A  28
GLN A  29
LEU A  95
PHE A  91
 None
 0.85A 5z84C-1kkcA:
2.2
5z84J-1kkcA:
undetectable		 5z84C-1kkcA:
19.93
5z84J-1kkcA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kl7 THREONINE SYNTHASE

(Saccharomyces
cerevisiae) 		PF00291
(PALP)
PF14821
(Thr_synth_N) 		4 LEU A  83
PHE A 130
LEU A 134
PHE A 138
 None
 0.72A 5z84C-1kl7A:
0.0
5z84J-1kl7A:
0.0		 5z84C-1kl7A:
21.24
5z84J-1kl7A:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m33 BIOH PROTEIN

(Escherichia
coli) 		PF00561
(Abhydrolase_1) 		4 LEU A 132
GLN A 131
PHE A 128
LEU A 176
 None
 0.91A 5z84C-1m33A:
undetectable
5z84J-1m33A:
undetectable		 5z84C-1m33A:
20.57
5z84J-1m33A:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ny5 TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)

(Aquifex
aeolicus) 		PF00072
(Response_reg)
PF00158
(Sigma54_activat) 		4 LEU A 194
PHE A 204
LEU A 208
PHE A 227
 None
 0.84A 5z84C-1ny5A:
0.0
5z84J-1ny5A:
undetectable		 5z84C-1ny5A:
19.75
5z84J-1ny5A:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o4s ASPARTATE
AMINOTRANSFERASE

(Thermotoga
maritima) 		PF00155
(Aminotran_1_2) 		4 LEU A 301
PHE A 308
LEU A 317
PHE A 356
 None
 0.92A 5z84C-1o4sA:
undetectable
5z84J-1o4sA:
undetectable		 5z84C-1o4sA:
21.52
5z84J-1o4sA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE

(Escherichia
coli) 		PF04055
(Radical_SAM)
PF06969
(HemN_C) 		5 LEU A 277
GLN A   4
PHE A 284
PHE A 290
PHE A 222
 None
 1.34A 5z84C-1oltA:
undetectable
5z84J-1oltA:
undetectable		 5z84C-1oltA:
20.00
5z84J-1oltA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ovl ORPHAN NUCLEAR
RECEPTOR NURR1 (MSE
496, 511)

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU B 570
GLN B 571
PHE B 574
PHE B 592
 None
 0.67A 5z84C-1ovlB:
undetectable
5z84J-1ovlB:
undetectable		 5z84C-1ovlB:
19.94
5z84J-1ovlB:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ovl ORPHAN NUCLEAR
RECEPTOR NURR1 (MSE
496, 511)

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU B 570
PHE B 574
PHE B 592
LEU B 596
 None
 0.87A 5z84C-1ovlB:
undetectable
5z84J-1ovlB:
undetectable		 5z84C-1ovlB:
19.94
5z84J-1ovlB:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgr PROTEIN (G-CSF
RECEPTOR)

(Mus musculus) 		no annotation 4 LEU B 187
GLN B 188
LEU B 176
PHE B 174
 None
 0.91A 5z84C-1pgrB:
undetectable
5z84J-1pgrB:
undetectable		 5z84C-1pgrB:
19.10
5z84J-1pgrB:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rj7 ECTODYSPLASIN A

(Homo sapiens) 		PF00229
(TNF) 		4 LEU A 253
GLN A 254
LEU A 293
PHE A 284
 None
 0.95A 5z84C-1rj7A:
undetectable
5z84J-1rj7A:
undetectable		 5z84C-1rj7A:
19.93
5z84J-1rj7A:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rj7 ECTODYSPLASIN A

(Homo sapiens) 		PF00229
(TNF) 		4 LEU A 253
GLN A 254
PHE A 379
PHE A 284
 None
 0.90A 5z84C-1rj7A:
undetectable
5z84J-1rj7A:
undetectable		 5z84C-1rj7A:
19.93
5z84J-1rj7A:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 418
GLN A 420
PHE A 501
LEU A 473
 None
 0.84A 5z84C-1snxA:
undetectable
5z84J-1snxA:
undetectable		 5z84C-1snxA:
19.44
5z84J-1snxA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svr SEVERIN

(Dictyostelium
discoideum) 		PF00626
(Gelsolin) 		4 GLN A 200
PHE A 201
PHE A 245
LEU A 249
 None
 0.79A 5z84C-1svrA:
undetectable
5z84J-1svrA:
undetectable		 5z84C-1svrA:
17.37
5z84J-1svrA:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u8v GAMMA-AMINOBUTYRATE
METABOLISM
DEHYDRATASE/ISOMERAS
E

(Clostridium
aminobutyricum) 		PF03241
(HpaB)
PF11794
(HpaB_N) 		4 ARG A 433
LEU A 437
LEU A 391
PHE A 422
 None
 0.90A 5z84C-1u8vA:
3.8
5z84J-1u8vA:
undetectable		 5z84C-1u8vA:
19.70
5z84J-1u8vA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uik ALPHA PRIME SUBUNIT
OF BETA-CONGLYCININ

(Glycine max) 		PF00190
(Cupin_1) 		4 LEU A 387
PHE A 360
LEU A 394
PHE A 481
 None
 0.94A 5z84C-1uikA:
undetectable
5z84J-1uikA:
undetectable		 5z84C-1uikA:
20.00
5z84J-1uikA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v8d HYPOTHETICAL PROTEIN
(TT1679)

(Thermus
thermophilus) 		PF04260
(DUF436) 		4 LEU A  55
GLN A  56
LEU A 100
PHE A  66
 None
 0.87A 5z84C-1v8dA:
undetectable
5z84J-1v8dA:
undetectable		 5z84C-1v8dA:
21.82
5z84J-1v8dA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vku ACYL CARRIER PROTEIN

(Thermotoga
maritima) 		PF00550
(PP-binding) 		4 LEU A  70
PHE A  48
LEU A  44
PHE A  36
 None
 0.73A 5z84C-1vkuA:
undetectable
5z84J-1vkuA:
undetectable		 5z84C-1vkuA:
13.64
5z84J-1vkuA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wgm UBIQUITIN
CONJUGATION FACTOR
E4A

(Homo sapiens) 		PF04564
(U-box) 		4 LEU A  67
GLN A  58
LEU A  38
PHE A  62
 None
 0.91A 5z84C-1wgmA:
undetectable
5z84J-1wgmA:
undetectable		 5z84C-1wgmA:
17.43
5z84J-1wgmA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wod MODA

(Escherichia
coli) 		PF13531
(SBP_bac_11) 		5 LEU A  80
PHE A 230
PHE A 225
LEU A 216
PHE A 212
 None
 1.36A 5z84C-1wodA:
undetectable
5z84J-1wodA:
undetectable		 5z84C-1wodA:
19.08
5z84J-1wodA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wrj METHYLATED-DNA--PROT
EIN-CYSTEINE
METHYLTRANSFERASE

(Sulfurisphaera
tokodaii) 		PF01035
(DNA_binding_1) 		4 LEU A  60
PHE A  45
LEU A  49
PHE A  53
 None
 0.90A 5z84C-1wrjA:
undetectable
5z84J-1wrjA:
undetectable		 5z84C-1wrjA:
16.60
5z84J-1wrjA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xho CHORISMATE MUTASE

(Ruminiclostridium
thermocellum) 		PF07736
(CM_1) 		4 ARG A  62
GLN A  24
PHE A  46
LEU A  71
 None
 0.95A 5z84C-1xhoA:
undetectable
5z84J-1xhoA:
undetectable		 5z84C-1xhoA:
17.72
5z84J-1xhoA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xw8 UPF0271 PROTEIN YBGL

(Escherichia
coli) 		PF03746
(LamB_YcsF) 		4 LEU A   5
PHE A 235
LEU A 231
PHE A 227
 None
 0.92A 5z84C-1xw8A:
undetectable
5z84J-1xw8A:
undetectable		 5z84C-1xw8A:
18.97
5z84J-1xw8A:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xw8 UPF0271 PROTEIN YBGL

(Escherichia
coli) 		PF03746
(LamB_YcsF) 		5 LEU A 188
GLN A 186
PHE A 227
LEU A 231
PHE A 235
 None
 1.03A 5z84C-1xw8A:
undetectable
5z84J-1xw8A:
undetectable		 5z84C-1xw8A:
18.97
5z84J-1xw8A:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli) 		PF04952
(AstE_AspA) 		4 LEU A 184
PHE A 158
LEU A 176
PHE A 172
 None
 0.88A 5z84C-1yw6A:
undetectable
5z84J-1yw6A:
undetectable		 5z84C-1yw6A:
20.54
5z84J-1yw6A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7m ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT

(Lactococcus
lactis) 		PF13393
(tRNA-synt_His) 		4 LEU A 236
PHE A 240
PHE A 168
LEU A 172
 None
 0.75A 5z84C-1z7mA:
undetectable
5z84J-1z7mA:
undetectable		 5z84C-1z7mA:
20.44
5z84J-1z7mA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zes PHOSPHATE REGULON
TRANSCRIPTIONAL
REGULATORY PROTEIN
PHOB

(Escherichia
coli) 		PF00072
(Response_reg) 		4 LEU A  42
GLN A  41
PHE A  64
LEU A  68
 None
 0.76A 5z84C-1zesA:
undetectable
5z84J-1zesA:
undetectable		 5z84C-1zesA:
16.80
5z84J-1zesA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buk COAT PROTEIN

(unidentified
tobacco
necrosis virus) 		PF03898
(TNV_CP) 		4 LEU A 174
GLN A  45
PHE A 172
PHE A  90
 None
 0.90A 5z84C-2bukA:
undetectable
5z84J-2bukA:
undetectable		 5z84C-2bukA:
21.37
5z84J-2bukA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ciu IMPORT INNER
MEMBRANE TRANSLOCASE
SUBUNIT TIM21
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF08294
(TIM21) 		5 LEU A 108
GLN A 107
PHE A 200
LEU A 187
PHE A 174
 None
 1.40A 5z84C-2ciuA:
undetectable
5z84J-2ciuA:
undetectable		 5z84C-2ciuA:
22.75
5z84J-2ciuA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpy FLAGELLUM-SPECIFIC
ATP SYNTHASE

(Salmonella
enterica) 		PF00006
(ATP-synt_ab) 		4 LEU A 428
PHE A 431
PHE A 391
LEU A 395
 None
 0.92A 5z84C-2dpyA:
undetectable
5z84J-2dpyA:
undetectable		 5z84C-2dpyA:
20.50
5z84J-2dpyA:
7.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epk N-ACETYL-BETA-D-GLUC
OSAMINIDASE

(Streptococcus
gordonii) 		PF00728
(Glyco_hydro_20) 		5 LEU X 495
GLN X 542
PHE X 543
PHE X 343
LEU X 446
 None
 1.43A 5z84C-2epkX:
3.6
5z84J-2epkX:
undetectable		 5z84C-2epkX:
16.85
5z84J-2epkX:
5.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fef HYPOTHETICAL PROTEIN
PA2201

(Pseudomonas
aeruginosa) 		PF08929
(DUF1911) 		4 LEU A 173
GLN A 174
PHE A 175
LEU A 153
 None
 0.89A 5z84C-2fefA:
2.3
5z84J-2fefA:
undetectable		 5z84C-2fefA:
23.55
5z84J-2fefA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fnu AMINOTRANSFERASE

(Helicobacter
pylori) 		PF01041
(DegT_DnrJ_EryC1) 		4 LEU A 243
GLN A 242
PHE A  37
LEU A  41
 None
 0.76A 5z84C-2fnuA:
undetectable
5z84J-2fnuA:
undetectable		 5z84C-2fnuA:
20.38
5z84J-2fnuA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gtr CHROMODOMAIN Y-LIKE
PROTEIN

(Homo sapiens) 		PF00378
(ECH_1) 		4 ARG A 219
LEU A 226
GLN A 228
LEU A 122
 None
 0.92A 5z84C-2gtrA:
undetectable
5z84J-2gtrA:
undetectable		 5z84C-2gtrA:
20.20
5z84J-2gtrA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2haj DNA PRIMASE

(Escherichia
coli) 		PF08278
(DnaG_DnaB_bind) 		4 LEU A 454
PHE A 535
LEU A 539
PHE A 543
 None
 0.72A 5z84C-2hajA:
undetectable
5z84J-2hajA:
undetectable		 5z84C-2hajA:
19.01
5z84J-2hajA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hxg L-ARABINOSE
ISOMERASE

(Escherichia
coli) 		PF02610
(Arabinose_Isome)
PF11762
(Arabinose_Iso_C) 		5 LEU A 296
GLN A 294
PHE A 303
PHE A 275
LEU A 267
 None
 1.42A 5z84C-2hxgA:
undetectable
5z84J-2hxgA:
undetectable		 5z84C-2hxgA:
20.04
5z84J-2hxgA:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6x HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Porphyromonas
gingivalis) 		PF13419
(HAD_2) 		5 LEU A 106
PHE A   7
PHE A 134
LEU A 130
PHE A 123
 None
 1.37A 5z84C-2i6xA:
undetectable
5z84J-2i6xA:
undetectable		 5z84C-2i6xA:
20.30
5z84J-2i6xA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ibd POSSIBLE
TRANSCRIPTIONAL
REGULATOR

(Rhodococcus
jostii) 		PF00440
(TetR_N) 		4 LEU A 131
PHE A 135
PHE A  74
LEU A  70
 None
 0.90A 5z84C-2ibdA:
undetectable
5z84J-2ibdA:
undetectable		 5z84C-2ibdA:
24.73
5z84J-2ibdA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2in3 HYPOTHETICAL PROTEIN

(Nitrosomonas
europaea) 		PF01323
(DSBA) 		4 GLN A 117
PHE A 120
LEU A 133
PHE A 151
 None
 0.93A 5z84C-2in3A:
undetectable
5z84J-2in3A:
undetectable		 5z84C-2in3A:
22.22
5z84J-2in3A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3t TRAFFICKING PROTEIN
PARTICLE COMPLEX
SUBUNIT 1

(Mus musculus) 		PF04099
(Sybindin) 		4 ARG C  94
GLN C  65
PHE C  64
PHE C  61
 None
 0.93A 5z84C-2j3tC:
undetectable
5z84J-2j3tC:
undetectable		 5z84C-2j3tC:
20.75
5z84J-2j3tC:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lkl ERYTHROCYTE MEMBRANE
PROTEIN 1 (PFEMP1)

(Plasmodium
falciparum) 		PF15445
(ATS) 		4 LEU A  54
PHE A  21
LEU A  17
PHE A   9
 None
 0.86A 5z84C-2lklA:
undetectable
5z84J-2lklA:
undetectable		 5z84C-2lklA:
13.41
5z84J-2lklA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nqi CALPAIN-1 CATALYTIC
SUBUNIT

(Rattus
norvegicus) 		PF00648
(Peptidase_C2) 		4 LEU A  55
GLN A  57
PHE A  56
PHE A 141
 None
 0.92A 5z84C-2nqiA:
undetectable
5z84J-2nqiA:
undetectable		 5z84C-2nqiA:
18.98
5z84J-2nqiA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nt8 COBALAMIN
ADENOSYLTRANSFERASE

(Lactobacillus
reuteri) 		PF01923
(Cob_adeno_trans) 		4 LEU A  95
PHE A 154
LEU A 158
PHE A 162
 None
 0.83A 5z84C-2nt8A:
2.8
5z84J-2nt8A:
undetectable		 5z84C-2nt8A:
21.30
5z84J-2nt8A:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2opt ACTII PROTEIN

(Streptomyces
coelicolor) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		4 ARG A  75
LEU A  79
PHE A  83
LEU A  49
 None
 0.68A 5z84C-2optA:
3.1
5z84J-2optA:
undetectable		 5z84C-2optA:
23.19
5z84J-2optA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1n SKP1-LIKE PROTEIN 1A
TRANSPORT INHIBITOR
RESPONSE 1 PROTEIN

(Arabidopsis
thaliana;
Arabidopsis
thaliana) 		PF01466
(Skp1)
PF03931
(Skp1_POZ)
PF12937
(F-box-like) 		4 PHE A  99
PHE B   9
LEU B  14
PHE B  18
 None
 0.94A 5z84C-2p1nA:
undetectable
5z84J-2p1nA:
undetectable		 5z84C-2p1nA:
18.58
5z84J-2p1nA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p25 GLYOXALASE FAMILY
PROTEIN

(Enterococcus
faecalis) 		PF00903
(Glyoxalase) 		4 LEU A 124
PHE A 114
LEU A  91
PHE A  90
 None
 0.84A 5z84C-2p25A:
undetectable
5z84J-2p25A:
undetectable		 5z84C-2p25A:
17.87
5z84J-2p25A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6v TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 4

(Homo sapiens) 		PF07531
(TAFH) 		4 LEU A 622
GLN A 624
PHE A 636
LEU A 640
 None
 0.86A 5z84C-2p6vA:
undetectable
5z84J-2p6vA:
undetectable		 5z84C-2p6vA:
18.34
5z84J-2p6vA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pn1 CARBAMOYLPHOSPHATE
SYNTHASE LARGE
SUBUNIT

(Exiguobacterium
sibiricum) 		PF02655
(ATP-grasp_3) 		4 LEU A 289
GLN A 288
PHE A  21
LEU A  76
 None
 0.84A 5z84C-2pn1A:
undetectable
5z84J-2pn1A:
undetectable		 5z84C-2pn1A:
20.12
5z84J-2pn1A:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q2r GLUCOKINASE 1,
PUTATIVE

(Trypanosoma
cruzi) 		PF02685
(Glucokinase) 		5 ARG A  83
LEU A  24
PHE A  26
PHE A  39
LEU A  15
 None
 1.41A 5z84C-2q2rA:
undetectable
5z84J-2q2rA:
undetectable		 5z84C-2q2rA:
21.78
5z84J-2q2rA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qp4 BILE SALT
SULFOTRANSFERASE

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		5 LEU A 269
GLN A 271
PHE A 270
PHE A 164
PHE A 150
 None
 1.47A 5z84C-2qp4A:
undetectable
5z84J-2qp4A:
undetectable		 5z84C-2qp4A:
20.83
5z84J-2qp4A:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2riu 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE

(Candida
albicans) 		PF00926
(DHBP_synthase) 		4 LEU A 113
PHE A  93
PHE A 123
LEU A  70
 None
 0.94A 5z84C-2riuA:
undetectable
5z84J-2riuA:
undetectable		 5z84C-2riuA:
21.66
5z84J-2riuA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wp0 HOBA
CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA

(Helicobacter
pylori;
Helicobacter
pylori) 		PF12163
(HobA)
no annotation 		4 LEU A  45
GLN C  52
LEU A 170
PHE A 171
 None
 0.80A 5z84C-2wp0A:
undetectable
5z84J-2wp0A:
undetectable		 5z84C-2wp0A:
20.15
5z84J-2wp0A:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y0n MALE-SPECIFIC LETHAL
3 HOMOLOG

(Homo sapiens) 		PF05712
(MRG) 		4 LEU A 180
PHE A 499
LEU A 491
PHE A 487
 None
 0.95A 5z84C-2y0nA:
undetectable
5z84J-2y0nA:
undetectable		 5z84C-2y0nA:
18.22
5z84J-2y0nA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 LEU A 818
PHE A 822
PHE A 832
LEU A 836
 None
 0.75A 5z84C-2yd0A:
undetectable
5z84J-2yd0A:
undetectable		 5z84C-2yd0A:
14.57
5z84J-2yd0A:
4.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2s RPOE, ECF SIGE

(Rhodobacter
sphaeroides) 		PF04542
(Sigma70_r2)
PF04545
(Sigma70_r4) 		4 ARG A  73
LEU A 176
GLN A 178
LEU A 103
 None
 0.86A 5z84C-2z2sA:
undetectable
5z84J-2z2sA:
undetectable		 5z84C-2z2sA:
18.66
5z84J-2z2sA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zou SPONDIN-1

(Homo sapiens) 		PF02014
(Reeler) 		5 LEU A 177
GLN A 172
PHE A 171
LEU A  82
PHE A  90
 EDO  A   6 (-3.8A)
EDO  A   6 (-4.9A)
None
None
None
 1.38A 5z84C-2zouA:
undetectable
5z84J-2zouA:
undetectable		 5z84C-2zouA:
15.85
5z84J-2zouA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxx DNA REPLICATION
FACTOR CDT1

(Mus musculus) 		PF08839
(CDT1) 		4 LEU C 199
GLN C 191
LEU C 314
PHE C 310
 None
 0.86A 5z84C-2zxxC:
undetectable
5z84J-2zxxC:
undetectable		 5z84C-2zxxC:
20.21
5z84J-2zxxC:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3i PENICILLIN-BINDING
PROTEIN 4

(Haemophilus
influenzae) 		PF02113
(Peptidase_S13) 		4 GLN A 235
PHE A 251
LEU A 249
PHE A 247
 None
 0.78A 5z84C-3a3iA:
undetectable
5z84J-3a3iA:
undetectable		 5z84C-3a3iA:
20.00
5z84J-3a3iA:
8.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ba3 PYRIDOXAMINE
5'-PHOSPHATE
OXIDASE-LIKE PROTEIN

(Lactobacillus
plantarum) 		no annotation 5 LEU A 123
GLN A  87
PHE A 121
PHE A  45
LEU A  18
 None
 0.91A 5z84C-3ba3A:
undetectable
5z84J-3ba3A:
undetectable		 5z84C-3ba3A:
21.19
5z84J-3ba3A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cr8 SULFATE
ADENYLYLTRANSFERASE,
ADENYLYLSULFATE
KINASE

(Thiobacillus
denitrificans) 		PF01583
(APS_kinase)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 LEU A  74
GLN A  73
PHE A  79
LEU A  56
 None
 0.92A 5z84C-3cr8A:
undetectable
5z84J-3cr8A:
undetectable		 5z84C-3cr8A:
20.53
5z84J-3cr8A:
6.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1d RNA-INDUCED
TRANSCRIPTIONAL
SILENCING COMPLEX
PROTEIN TAS3

(Schizosaccharomyces
pombe) 		no annotation 5 LEU A 477
GLN A 475
PHE A 473
LEU A 443
PHE A 449
 None
 1.45A 5z84C-3d1dA:
undetectable
5z84J-3d1dA:
undetectable		 5z84C-3d1dA:
19.47
5z84J-3d1dA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dqv CULLIN-5

(Homo sapiens) 		PF00888
(Cullin)
PF10557
(Cullin_Nedd8) 		4 LEU C1600
GLN C1599
PHE C1598
LEU C1551
 None
 0.92A 5z84C-3dqvC:
undetectable
5z84J-3dqvC:
undetectable		 5z84C-3dqvC:
20.37
5z84J-3dqvC:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dra GERANYLGERANYLTRANSF
ERASE TYPE I BETA
SUBUNIT

(Candida
albicans) 		PF00432
(Prenyltrans) 		4 LEU B   4
GLN B   3
PHE B 365
LEU B 357
 None
 0.95A 5z84C-3draB:
undetectable
5z84J-3draB:
undetectable		 5z84C-3draB:
18.70
5z84J-3draB:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3exn PROBABLE
ACETYLTRANSFERASE

(Thermus
thermophilus) 		PF00583
(Acetyltransf_1) 		4 LEU A  63
PHE A  62
LEU A  22
PHE A  26
 None
 0.91A 5z84C-3exnA:
undetectable
5z84J-3exnA:
undetectable		 5z84C-3exnA:
23.02
5z84J-3exnA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eyk HEMAGGLUTININ HA1
CHAIN

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 LEU A 118
GLN A  80
PHE A 120
LEU A 112
 None
 0.88A 5z84C-3eykA:
undetectable
5z84J-3eykA:
undetectable		 5z84C-3eykA:
21.21
5z84J-3eykA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fnr ARGINYL-TRNA
SYNTHETASE

(Campylobacter
jejuni) 		PF00750
(tRNA-synt_1d)
PF05746
(DALR_1) 		4 LEU A 108
PHE A 106
PHE A 144
PHE A 129
 None
 0.95A 5z84C-3fnrA:
3.3
5z84J-3fnrA:
undetectable		 5z84C-3fnrA:
20.22
5z84J-3fnrA:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1z PUTATIVE LYSYL-TRNA
SYNTHETASE

(Salmonella
enterica) 		PF00152
(tRNA-synt_2) 		4 ARG A 188
LEU A 192
PHE A 196
PHE A 153
 None
 0.88A 5z84C-3g1zA:
undetectable
5z84J-3g1zA:
undetectable		 5z84C-3g1zA:
20.94
5z84J-3g1zA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO

(Thermus
thermophilus) 		PF01134
(GIDA) 		4 LEU A 289
GLN A 291
PHE A 199
LEU A 203
 None
 0.87A 5z84C-3g5sA:
undetectable
5z84J-3g5sA:
undetectable		 5z84C-3g5sA:
20.48
5z84J-3g5sA:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gaj COBALAMIN
ADENOSYLTRANSFERASE
PDUO-LIKE PROTEIN

(Lactobacillus
reuteri) 		PF01923
(Cob_adeno_trans) 		4 LEU A  95
PHE A 154
LEU A 158
PHE A 162
 None
 0.83A 5z84C-3gajA:
2.7
5z84J-3gajA:
undetectable		 5z84C-3gajA:
21.16
5z84J-3gajA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzg MOLYBDATE-BINDING
PERIPLASMIC PROTEIN
PERMEASE

(Xanthomonas
citri) 		PF13531
(SBP_bac_11) 		5 LEU A  80
PHE A 230
PHE A 225
LEU A 216
PHE A 212
 None
 1.32A 5z84C-3gzgA:
undetectable
5z84J-3gzgA:
undetectable		 5z84C-3gzgA:
24.09
5z84J-3gzgA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4l DNA MISMATCH REPAIR
PROTEIN PMS1

(Saccharomyces
cerevisiae) 		PF01119
(DNA_mis_repair)
PF13589
(HATPase_c_3) 		4 LEU A 181
GLN A 180
PHE A 192
LEU A  55
 None
 0.77A 5z84C-3h4lA:
undetectable
5z84J-3h4lA:
undetectable		 5z84C-3h4lA:
19.18
5z84J-3h4lA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		4 LEU A 196
GLN A 193
PHE A 200
LEU A 162
 None
 0.87A 5z84C-3hjrA:
undetectable
5z84J-3hjrA:
undetectable		 5z84C-3hjrA:
17.67
5z84J-3hjrA:
6.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00109
(ketoacyl-synt)
PF01648
(ACPS)
PF02801
(Ketoacyl-synt_C) 		4 LEU A 916
GLN A 918
LEU A 640
PHE A 659
 None
 0.90A 5z84C-3hmjA:
3.3
5z84J-3hmjA:
undetectable		 5z84C-3hmjA:
8.54
5z84J-3hmjA:
3.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3t UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 21

(Homo sapiens) 		PF00443
(UCH) 		5 LEU A 378
GLN A 453
PHE A 397
LEU A 400
PHE A 420
 None
 1.13A 5z84C-3i3tA:
undetectable
5z84J-3i3tA:
undetectable		 5z84C-3i3tA:
21.07
5z84J-3i3tA:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ih6 PUTATIVE ZINC
PROTEASE

(Bordetella
pertussis) 		PF05193
(Peptidase_M16_C) 		4 LEU A 365
PHE A 370
LEU A 305
PHE A 341
 None
 0.94A 5z84C-3ih6A:
undetectable
5z84J-3ih6A:
undetectable		 5z84C-3ih6A:
21.89
5z84J-3ih6A:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iv0 SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 LEU A 230
PHE A 151
LEU A 155
PHE A 159
 None
 0.77A 5z84C-3iv0A:
1.9
5z84J-3iv0A:
undetectable		 5z84C-3iv0A:
20.57
5z84J-3iv0A:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9d OUTER CAPSID PROTEIN
VP2

(Bluetongue
virus) 		PF00898
(Orbi_VP2) 		4 LEU A 530
PHE A 569
LEU A 566
PHE A 526
 None
 0.94A 5z84C-3j9dA:
undetectable
5z84J-3j9dA:
undetectable		 5z84C-3j9dA:
13.31
5z84J-3j9dA:
5.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k40 AROMATIC-L-AMINO-ACI
D DECARBOXYLASE

(Drosophila
melanogaster) 		PF00282
(Pyridoxal_deC) 		4 LEU A 114
PHE A 354
LEU A 357
PHE A 361
 None
 0.95A 5z84C-3k40A:
undetectable
5z84J-3k40A:
undetectable		 5z84C-3k40A:
19.79
5z84J-3k40A:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6a EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2

(Homo sapiens) 		PF02020
(W2)
PF02847
(MA3) 		4 LEU A 106
GLN A 108
PHE A  85
LEU A  89
 None
 0.85A 5z84C-3l6aA:
undetectable
5z84J-3l6aA:
undetectable		 5z84C-3l6aA:
20.70
5z84J-3l6aA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6c SERINE RACEMASE

(Rattus
norvegicus) 		PF00291
(PALP) 		4 LEU A 171
GLN A 173
LEU A 200
PHE A   9
 None
 0.89A 5z84C-3l6cA:
undetectable
5z84J-3l6cA:
undetectable		 5z84C-3l6cA:
21.73
5z84J-3l6cA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6r SERINE RACEMASE

(Homo sapiens) 		PF00291
(PALP) 		4 LEU A 171
GLN A 173
LEU A 200
PHE A   9
 None
 0.86A 5z84C-3l6rA:
undetectable
5z84J-3l6rA:
undetectable		 5z84C-3l6rA:
21.74
5z84J-3l6rA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lcr TAUTOMYCETIN
BIOSYNTHETIC PKS

(Streptomyces
sp. CK4412) 		PF00975
(Thioesterase) 		5 LEU A 229
GLN A 227
PHE A 174
LEU A 178
PHE A 182
 None
 1.40A 5z84C-3lcrA:
undetectable
5z84J-3lcrA:
undetectable		 5z84C-3lcrA:
20.45
5z84J-3lcrA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nbu GLUCOSE-6-PHOSPHATE
ISOMERASE

(Escherichia
coli) 		PF00342
(PGI) 		4 LEU A  15
GLN A  16
PHE A  19
LEU A  66
 None
 0.79A 5z84C-3nbuA:
undetectable
5z84J-3nbuA:
undetectable		 5z84C-3nbuA:
18.63
5z84J-3nbuA:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nhe UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2

(Homo sapiens) 		PF00443
(UCH) 		4 LEU A 419
GLN A 492
PHE A 438
LEU A 441
 None
 0.93A 5z84C-3nheA:
undetectable
5z84J-3nheA:
undetectable		 5z84C-3nheA:
20.23
5z84J-3nheA:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nj2 DUF269-CONTAINING
PROTEIN

(Cyanothece sp.
ATCC 51142) 		PF03270
(DUF269) 		5 LEU A  40
GLN A  43
PHE A  36
LEU A 150
PHE A 144
 None
 1.35A 5z84C-3nj2A:
undetectable
5z84J-3nj2A:
undetectable		 5z84C-3nj2A:
20.45
5z84J-3nj2A:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ob4 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ARAH 2

(Escherichia
coli;
Arachis
duranensis) 		PF00234
(Tryp_alpha_amyl)
PF13416
(SBP_bac_8) 		4 LEU A1046
GLN A1044
PHE A1126
LEU A1130
 None
 0.90A 5z84C-3ob4A:
undetectable
5z84J-3ob4A:
undetectable		 5z84C-3ob4A:
15.02
5z84J-3ob4A:
7.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ob4 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ARAH 2

(Escherichia
coli;
Arachis
duranensis) 		PF00234
(Tryp_alpha_amyl)
PF13416
(SBP_bac_8) 		4 LEU A1046
GLN A1048
PHE A1126
LEU A1130
 None
 0.84A 5z84C-3ob4A:
undetectable
5z84J-3ob4A:
undetectable		 5z84C-3ob4A:
15.02
5z84J-3ob4A:
7.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ofj NODULATION PROTEIN S

(Bradyrhizobium
sp. WM9) 		PF05401
(NodS) 		4 LEU A  36
GLN A  34
PHE A  58
LEU A  62
 None
 0.88A 5z84C-3ofjA:
undetectable
5z84J-3ofjA:
undetectable		 5z84C-3ofjA:
21.83
5z84J-3ofjA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqq PUTATIVE LIPOPROTEIN

(Bacteroides
ovatus) 		PF16129
(DUF4841)
PF16130
(DUF4842) 		4 LEU A 214
PHE A 152
PHE A 173
LEU A 201
 None
 0.92A 5z84C-3oqqA:
undetectable
5z84J-3oqqA:
undetectable		 5z84C-3oqqA:
20.13
5z84J-3oqqA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3os4 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Yersinia pestis) 		PF04095
(NAPRTase) 		4 LEU A 150
GLN A 149
LEU A 192
PHE A 196
 None
 0.87A 5z84C-3os4A:
undetectable
5z84J-3os4A:
undetectable		 5z84C-3os4A:
20.76
5z84J-3os4A:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4i PHOSPHOHYDROLASE
(MUTT/NUDIX FAMILY
PROTEIN)

(Bacillus cereus) 		PF00293
(NUDIX)
PF12535
(Nudix_N) 		4 LEU A  81
PHE A  83
LEU A  94
PHE A 148
 None
 0.72A 5z84C-3q4iA:
3.6
5z84J-3q4iA:
undetectable		 5z84C-3q4iA:
20.44
5z84J-3q4iA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qde CELLOBIOSE
PHOSPHORYLASE

(Ruminiclostridium
thermocellum) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 LEU A 134
GLN A 255
LEU A 146
PHE A  72
 None
 0.90A 5z84C-3qdeA:
undetectable
5z84J-3qdeA:
undetectable		 5z84C-3qdeA:
15.31
5z84J-3qdeA:
4.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qdn PUTATIVE THIOREDOXIN
PROTEIN

(Salmonella
enterica) 		PF00085
(Thioredoxin)
PF14559
(TPR_19)
PF14561
(TPR_20) 		4 LEU A 236
PHE A 240
PHE A 258
LEU A 262
 None
 0.64A 5z84C-3qdnA:
undetectable
5z84J-3qdnA:
undetectable		 5z84C-3qdnA:
21.02
5z84J-3qdnA:
11.31