SIMILAR PATTERNS OF AMINO ACIDS FOR 5Z6J_A_FOLA201_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a88 CHLOROPEROXIDASE L

(Streptomyces
lividans) 		PF00561
(Abhydrolase_1) 		3 MET A  41
ASP A  35
ARG A  56
 None
 0.87A 5z6jA-1a88A:
1.5		 5z6jA-1a88A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a8s CHLOROPEROXIDASE F

(Pseudomonas
fluorescens) 		PF00561
(Abhydrolase_1) 		3 MET A  39
ASP A  33
ARG A  54
 None
 0.90A 5z6jA-1a8sA:
undetectable		 5z6jA-1a8sA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ajz DIHYDROPTEROATE
SYNTHASE

(Escherichia
coli) 		PF00809
(Pterin_bind) 		3 MET A 139
ASP A  96
ARG A  63
 None
None
SO4  A 283 (-3.9A)
 1.21A 5z6jA-1ajzA:
undetectable		 5z6jA-1ajzA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1crk CREATINE KINASE

(Gallus gallus) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		3 MET A 202
ASP A 228
ARG A  91
 None
 0.99A 5z6jA-1crkA:
undetectable		 5z6jA-1crkA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1edg ENDOGLUCANASE A

([Clostridium]
cellulolyticum) 		PF00150
(Cellulase) 		3 MET A 138
ASP A 202
ARG A 237
 None
 1.21A 5z6jA-1edgA:
0.0		 5z6jA-1edgA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nrz PTS SYSTEM,
SORBOSE-SPECIFIC IIB
COMPONENT

(Klebsiella
pneumoniae) 		PF03830
(PTSIIB_sorb) 		3 MET A 108
ASP A 124
ARG A 132
 None
 1.06A 5z6jA-1nrzA:
2.6		 5z6jA-1nrzA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ocx MALTOSE
O-ACETYLTRANSFERASE

(Escherichia
coli) 		PF12464
(Mac)
PF14602
(Hexapep_2) 		3 MET A   8
ASP A  90
ARG A  27
 None
 1.05A 5z6jA-1ocxA:
undetectable		 5z6jA-1ocxA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pqu ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Haemophilus
influenzae) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		3 MET A 143
ASP A 113
ARG A  20
 None
 1.14A 5z6jA-1pquA:
1.6		 5z6jA-1pquA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qk1 CREATINE KINASE,
UBIQUITOUS
MITOCHONDRIAL

(Homo sapiens) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		3 MET A 202
ASP A 228
ARG A  91
 None
 1.03A 5z6jA-1qk1A:
0.0		 5z6jA-1qk1A:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qxo CHORISMATE SYNTHASE

(Streptococcus
pneumoniae) 		PF01264
(Chorismate_synt) 		3 MET A  88
ASP A 123
ARG A 107
 None
None
EPS  A5001 ( 4.4A)
 1.16A 5z6jA-1qxoA:
undetectable		 5z6jA-1qxoA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcn CTP SYNTHETASE

(Thermus
thermophilus) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		3 MET A 497
ASP A 445
ARG A  95
 None
 1.21A 5z6jA-1vcnA:
4.1		 5z6jA-1vcnA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wue MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Enterococcus
faecalis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 MET A1187
ASP A1316
ARG A1266
 None
 1.12A 5z6jA-1wueA:
undetectable		 5z6jA-1wueA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3i OVOTRANSFERRIN

(Gallus gallus) 		PF00405
(Transferrin) 		3 MET A 679
ASP A 315
ARG A 597
 None
 1.20A 5z6jA-2d3iA:
undetectable		 5z6jA-2d3iA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkk CYTOCHROME P450

(Streptomyces
coelicolor) 		PF00067
(p450) 		3 MET A  37
ASP A 335
ARG A 398
 None
 1.16A 5z6jA-2dkkA:
undetectable		 5z6jA-2dkkA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fia ACETYLTRANSFERASE

(Enterococcus
faecalis) 		PF00583
(Acetyltransf_1) 		3 MET A  64
ASP A  46
ARG A 143
 None
 1.18A 5z6jA-2fiaA:
undetectable		 5z6jA-2fiaA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqz R.ECL18KI

(Enterobacter
cloacae) 		PF09019
(EcoRII-C) 		3 MET A 204
ASP A 160
ARG A 188
 None
 0.82A 5z6jA-2fqzA:
undetectable		 5z6jA-2fqzA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gam BETA-1,6-N-ACETYLGLU
COSAMINYLTRANSFERASE

(Mus musculus) 		PF02485
(Branch) 		3 MET A  96
ASP A 137
ARG A  87
 None
 1.01A 5z6jA-2gamA:
undetectable		 5z6jA-2gamA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h4t CARNITINE
O-PALMITOYLTRANSFERA
SE II, MITOCHONDRIAL

(Rattus
norvegicus) 		PF00755
(Carn_acyltransf) 		3 MET A  43
ASP A 213
ARG A 219
 None
 1.21A 5z6jA-2h4tA:
undetectable		 5z6jA-2h4tA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2if7 SLAM FAMILY MEMBER 6

(Homo sapiens) 		PF07686
(V-set) 		3 MET A  79
ASP A 137
ARG A 109
 None
 1.07A 5z6jA-2if7A:
undetectable		 5z6jA-2if7A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jir PERIPLASMIC NITRATE
REDUCTASE

(Desulfovibrio
desulfuricans) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		3 MET A 303
ASP A 165
ARG A 477
 None
 1.17A 5z6jA-2jirA:
undetectable		 5z6jA-2jirA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8s AGR_C_984P

(Agrobacterium
fabrum) 		PF06748
(DUF1217) 		3 MET A 120
ASP A 147
ARG A 204
 None
 1.13A 5z6jA-2o8sA:
undetectable		 5z6jA-2o8sA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ov9 HYPOTHETICAL PROTEIN

(Rhodococcus
jostii) 		PF03061
(4HBT) 		3 MET A 179
ASP A 109
ARG A 193
 None
 1.18A 5z6jA-2ov9A:
undetectable		 5z6jA-2ov9A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vrs SIGMA-C CAPSID
PROTEIN

(Avian
orthoreovirus) 		PF04582
(Reo_sigmaC) 		3 MET A 198
ASP A 259
ARG A 299
 None
None
GOL  A1327 (-3.9A)
 0.96A 5z6jA-2vrsA:
undetectable		 5z6jA-2vrsA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yij PHOSPHOLIPASE
A1-IIGAMMA

(Arabidopsis
thaliana) 		PF01764
(Lipase_3) 		3 MET A  35
ASP A  42
ARG A 146
 None
 1.17A 5z6jA-2yijA:
undetectable		 5z6jA-2yijA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9s D-ARABINOSE
ISOMERASE

(Aeribacillus
pallidus) 		PF02952
(Fucose_iso_C)
PF07881
(Fucose_iso_N1)
PF07882
(Fucose_iso_N2) 		3 MET A 288
ASP A 277
ARG A 234
 None
 1.10A 5z6jA-3a9sA:
undetectable		 5z6jA-3a9sA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3esh PROTEIN SIMILAR TO
METAL-DEPENDENT
HYDROLASE

(Staphylococcus
aureus) 		PF00753
(Lactamase_B) 		3 MET A  23
ASP A 206
ARG A 273
 None
 1.08A 5z6jA-3eshA:
undetectable		 5z6jA-3eshA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gfv UNCHARACTERIZED ABC
TRANSPORTER
SOLUTE-BINDING
PROTEIN YCLQ

(Bacillus
subtilis) 		PF01497
(Peripla_BP_2) 		3 MET A 287
ASP A  46
ARG A 104
 None
None
PO4  A 304 (-4.0A)
 1.12A 5z6jA-3gfvA:
undetectable		 5z6jA-3gfvA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3he0 TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Vibrio
parahaemolyticus) 		PF00440
(TetR_N)
PF16295
(TetR_C_10) 		3 MET A  31
ASP A  51
ARG A  60
 None
 1.05A 5z6jA-3he0A:
undetectable		 5z6jA-3he0A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hea ARYLESTERASE

(Pseudomonas
fluorescens) 		PF00561
(Abhydrolase_1) 		3 MET A  39
ASP A  33
ARG A  54
 None
 0.89A 5z6jA-3heaA:
undetectable		 5z6jA-3heaA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica) 		PF03063
(Prismane) 		3 MET A 561
ASP A 570
ARG A 199
 None
 0.97A 5z6jA-3i04A:
undetectable		 5z6jA-3i04A:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4p TRANSCRIPTIONAL
REGULATOR, ASNC
FAMILY

(Agrobacterium
fabrum) 		PF01037
(AsnC_trans_reg)
PF13412
(HTH_24) 		3 MET A  41
ASP A   2
ARG A  10
 None
 1.05A 5z6jA-3i4pA:
undetectable		 5z6jA-3i4pA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3if9 GLYCINE OXIDASE

(Bacillus
subtilis) 		PF01266
(DAO) 		3 MET A 111
ASP A 145
ARG A 329
 None
None
GOA  A 370 ( 3.1A)
 0.93A 5z6jA-3if9A:
undetectable		 5z6jA-3if9A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7g XAA-PRO DIPEPTIDASE

(Alteromonas sp.) 		PF00557
(Peptidase_M24) 		3 MET A 168
ASP A 344
ARG A  18
 None
 1.21A 5z6jA-3l7gA:
undetectable		 5z6jA-3l7gA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l88 FIBER PROTEIN

(Human
mastadenovirus
B) 		PF00541
(Adeno_knob) 		3 MET A 184
ASP A 154
ARG A 195
 None
 0.86A 5z6jA-3l88A:
undetectable		 5z6jA-3l88A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n05 NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Streptomyces
avermitilis) 		PF00795
(CN_hydrolase)
PF02540
(NAD_synthase) 		3 MET A 146
ASP A 271
ARG A 205
 None
 1.00A 5z6jA-3n05A:
undetectable		 5z6jA-3n05A:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2c PROLIDASE

(unidentified) 		PF01979
(Amidohydro_1) 		3 MET A 190
ASP A 200
ARG A 144
 KCX  A 188 ( 3.8A)
None
None
 1.17A 5z6jA-3n2cA:
undetectable		 5z6jA-3n2cA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvt PHENYLACETIC ACID
DEGRADATION PROTEIN
PAAA

(Escherichia
coli) 		PF05138
(PaaA_PaaC) 		3 MET A 193
ASP A 260
ARG A 271
 None
 1.08A 5z6jA-3pvtA:
undetectable		 5z6jA-3pvtA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pzr ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Vibrio cholerae) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		3 MET A 141
ASP A 111
ARG A  19
 None
 1.12A 5z6jA-3pzrA:
undetectable		 5z6jA-3pzrA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rac HISTIDINE-TRNA
LIGASE

(Alicyclobacillus
acidocaldarius) 		PF13393
(tRNA-synt_His) 		3 MET A 161
ASP A 290
ARG A 251
 None
 1.15A 5z6jA-3racA:
undetectable		 5z6jA-3racA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tad LIPRIN-ALPHA-2

(Homo sapiens) 		PF00536
(SAM_1)
PF07647
(SAM_2) 		3 MET A 913
ASP A1047
ARG A 955
 None
 1.07A 5z6jA-3tadA:
undetectable		 5z6jA-3tadA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tm5 CRYSTAL STRUCTURE OF
TRM14

(Pyrococcus
furiosus) 		PF01170
(UPF0020)
PF02926
(THUMP) 		3 MET A 210
ASP A 223
ARG A 194
 None
None
SFG  A 401 ( 4.9A)
 1.17A 5z6jA-3tm5A:
2.7		 5z6jA-3tm5A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uw3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Burkholderia
thailandensis) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		3 MET A 141
ASP A 111
ARG A  19
 None
None
EDO  A 374 ( 4.9A)
 1.15A 5z6jA-3uw3A:
undetectable		 5z6jA-3uw3A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va8 PROBABLE DEHYDRATASE

(Fusarium
graminearum) 		PF13378
(MR_MLE_C) 		3 MET A 269
ASP A 220
ARG A 422
 None
MG  A 425 ( 2.4A)
None
 1.20A 5z6jA-3va8A:
undetectable		 5z6jA-3va8A:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vpz GLUCOKINASE

(Pseudoalteromonas
sp. AS-131) 		PF02685
(Glucokinase) 		3 MET A 214
ASP A 182
ARG A 288
 None
 1.18A 5z6jA-3vpzA:
undetectable		 5z6jA-3vpzA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfz LACTO-N-BIOSE
PHOSPHORYLASE

(Bifidobacterium
longum) 		PF09508
(Lact_bio_phlase)
PF17385
(LBP_M)
PF17386
(LBP_C) 		3 MET A 450
ASP A 283
ARG A 275
 None
 0.84A 5z6jA-3wfzA:
undetectable		 5z6jA-3wfzA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wrf NON-REDUCING END
BETA-L-ARABINOFURANO
SIDASE

(Bifidobacterium
longum) 		PF07944
(Glyco_hydro_127) 		3 MET A 147
ASP A 115
ARG A 212
 None
 1.18A 5z6jA-3wrfA:
undetectable		 5z6jA-3wrfA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES

(Mycolicibacterium
smegmatis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		3 MET A 348
ASP A 355
ARG A 312
 None
 0.92A 5z6jA-3zo9A:
undetectable		 5z6jA-3zo9A:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ak1 BT_4661

(Bacteroides
thetaiotaomicron) 		PF16319
(DUF4958) 		3 MET A 537
ASP A 540
ARG A 582
 None
 1.21A 5z6jA-4ak1A:
undetectable		 5z6jA-4ak1A:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		3 MET A 973
ASP A 700
ARG A 696
 None
 0.90A 5z6jA-4crsA:
undetectable		 5z6jA-4crsA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyo ASPARTYL
AMINOPEPTIDASE

(Homo sapiens) 		PF02127
(Peptidase_M18) 		3 MET A 439
ASP A 346
ARG A 380
 SD4  A 504 ( 3.7A)
ZN  A 502 ( 2.0A)
None
 1.18A 5z6jA-4dyoA:
undetectable		 5z6jA-4dyoA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eo4 THREONINE--TRNA
LIGASE,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		3 MET A 277
ASP A 266
ARG A 162
 None
None
SSA  A1001 (-2.8A)
 0.84A 5z6jA-4eo4A:
undetectable		 5z6jA-4eo4A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kp2 HOMOACONITASE LARGE
SUBUNIT

(Methanocaldococcus
jannaschii) 		PF00330
(Aconitase) 		3 MET A  30
ASP A  61
ARG A 385
 None
 0.87A 5z6jA-4kp2A:
undetectable		 5z6jA-4kp2A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lxf TREHALOSE SYNTHASE

(Mycobacterium
tuberculosis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		3 MET A 356
ASP A 363
ARG A 320
 None
 0.88A 5z6jA-4lxfA:
undetectable		 5z6jA-4lxfA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mbr SERINE-RICH REPEAT
PROTEIN 2

(Streptococcus
agalactiae) 		PF10425
(SdrG_C_C) 		3 MET A 460
ASP A 260
ARG A 384
 None
 1.20A 5z6jA-4mbrA:
undetectable		 5z6jA-4mbrA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mp3 PUTATIVE ORNITHINE
CYCLODEAMINASE

(Staphylococcus
aureus) 		PF02423
(OCD_Mu_crystall) 		3 MET A 121
ASP A 152
ARG A 189
 None
 1.16A 5z6jA-4mp3A:
undetectable		 5z6jA-4mp3A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nav HYPOTHETICAL PROTEIN
XCC279

(Xanthomonas
campestris) 		no annotation 3 MET D 116
ASP D  52
ARG D 151
 None
 0.94A 5z6jA-4navD:
2.9		 5z6jA-4navD:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE

(Geobacter
sulfurreducens) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		3 MET A 245
ASP A 285
ARG A 492
 None
 1.07A 5z6jA-4nmeA:
undetectable		 5z6jA-4nmeA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqj PKS

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		3 MET A 211
ASP A 273
ARG A 504
 None
 0.70A 5z6jA-4oqjA:
undetectable		 5z6jA-4oqjA:
10.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p68 DIHYDROFOLATE
REDUCTASE

(Escherichia
coli) 		PF00186
(DHFR_1) 		3 MET A  20
ASP A  27
ARG A  57
 MTX  A 201 ( 3.6A)
MTX  A 201 (-3.0A)
MTX  A 201 (-3.0A)
 0.38A 5z6jA-4p68A:
30.5		 5z6jA-4p68A:
98.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pel PENICILLIN G ACYLASE
SUBUNIT ALPHA
PENICILLIN G ACYLASE
SUBUNIT BETA

(Kluyvera
cryocrescens;
Kluyvera
cryocrescens) 		PF01804
(Penicil_amidase)
PF01804
(Penicil_amidase) 		3 MET B 527
ASP B 501
ARG A  39
 None
 0.97A 5z6jA-4pelB:
undetectable		 5z6jA-4pelB:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfs COBYRINIC ACID
A,C-DIAMIDE SYNTHASE

(Mycolicibacterium
smegmatis) 		PF13614
(AAA_31) 		3 MET A 265
ASP A 150
ARG A  40
 None
 1.20A 5z6jA-4pfsA:
3.3		 5z6jA-4pfsA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4plb CHIMERA PROTEIN OF
DNA GYRASE SUBUNITS
B AND A

(Staphylococcus
aureus) 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim) 		3 MET B1113
ASP B1294
ARG B1299
 None
 1.18A 5z6jA-4plbB:
undetectable		 5z6jA-4plbB:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6u UNCHARACTERIZED
PROTEIN

(Mycobacterium
tuberculosis) 		no annotation 3 MET A  75
ASP A 114
ARG A 109
 None
1PE  A 401 (-3.2A)
None
 0.91A 5z6jA-4q6uA:
undetectable		 5z6jA-4q6uA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		3 MET A2732
ASP A2794
ARG A3037
 None
 0.85A 5z6jA-4qyrA:
undetectable		 5z6jA-4qyrA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w5u CHITINASE

(Streptomyces
thermoviolaceus) 		no annotation 3 MET B 204
ASP B 179
ARG B 383
 None
 0.81A 5z6jA-4w5uB:
undetectable		 5z6jA-4w5uB:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wfi CUTINASE

(Saccharomonospora
viridis) 		PF03403
(PAF-AH_p_II) 		3 MET A 247
ASP A 292
ARG A 119
 None
 0.93A 5z6jA-4wfiA:
undetectable		 5z6jA-4wfiA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wgx MOLINATE HYDROLASE

(Gulosibacter
molinativorax) 		PF01979
(Amidohydro_1) 		3 MET A 274
ASP A 342
ARG A 156
 None
MPD  A 502 (-2.7A)
MPD  A 501 ( 4.2A)
 1.02A 5z6jA-4wgxA:
undetectable		 5z6jA-4wgxA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wky BETA-KETOACYL
SYNTHASE

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		3 MET A 211
ASP A 273
ARG A 500
 None
 0.81A 5z6jA-4wkyA:
undetectable		 5z6jA-4wkyA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yyf BETA-N-ACETYLHEXOSAM
INIDASE

(Mycolicibacterium
smegmatis) 		PF00933
(Glyco_hydro_3) 		3 MET A  94
ASP A 313
ARG A 195
 None
None
ACT  A 401 (-2.8A)
 1.16A 5z6jA-4yyfA:
undetectable		 5z6jA-4yyfA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		3 MET A2884
ASP A2903
ARG A2827
 None
 1.18A 5z6jA-4z37A:
undetectable		 5z6jA-4z37A:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		3 MET A 742
ASP A 756
ARG A 611
 None
 0.86A 5z6jA-4z7gA:
undetectable		 5z6jA-4z7gA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zg7 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2

(Homo sapiens) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		3 MET A 484
ASP A 474
ARG A 392
 None
None
CL  A 917 (-3.8A)
 1.20A 5z6jA-4zg7A:
1.3		 5z6jA-4zg7A:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa5 NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK
NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG

(Cupriavidus
necator;
Cupriavidus
necator) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C)
PF00374
(NiFeSe_Hases) 		3 MET A  77
ASP C  26
ARG C 568
 None
 1.10A 5z6jA-5aa5A:
undetectable		 5z6jA-5aa5A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cdi CHAPERONIN 60B1

(Chlamydomonas
reinhardtii) 		PF00118
(Cpn60_TCP1) 		3 MET A 194
ASP A 292
ARG A 351
 None
 1.03A 5z6jA-5cdiA:
undetectable		 5z6jA-5cdiA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6a PREDICTED ATPASE OF
THE ABC CLASS

(Vibrio
vulnificus) 		PF09818
(ABC_ATPase) 		3 MET A 385
ASP A 390
ARG A 374
 None
 1.05A 5z6jA-5d6aA:
undetectable		 5z6jA-5d6aA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6b FUMARATE HYDRATASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		3 MET A  77
ASP A  55
ARG A  51
 None
 1.00A 5z6jA-5d6bA:
undetectable		 5z6jA-5d6bA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6k POLYKETIDE SYNTHASE
PKSL

(Bacillus
subtilis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		3 MET A 190
ASP A 252
ARG A 482
 None
 0.96A 5z6jA-5e6kA:
undetectable		 5z6jA-5e6kA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eny POLYKETIDE SYNTHASE
PKSL

(Bacillus
subtilis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		3 MET A 190
ASP A 252
ARG A 482
 None
 0.98A 5z6jA-5enyA:
undetectable		 5z6jA-5enyA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fok IRON TRANSPORT OUTER
MEMBRANE RECEPTOR

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 MET A 701
ASP A 314
ARG A 270
 None
 1.08A 5z6jA-5fokA:
undetectable		 5z6jA-5fokA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jfc NADH-DEPENDENT
FERREDOXIN:NADP
OXIDOREDUCTASE
SUBUNIT ALPHA

(Pyrococcus
furiosus) 		PF07992
(Pyr_redox_2)
PF14691
(Fer4_20) 		3 MET L 456
ASP L 172
ARG L  89
 None
 1.21A 5z6jA-5jfcL:
undetectable		 5z6jA-5jfcL:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE

([Candida]
glabrata) 		PF00067
(p450) 		3 MET A 289
ASP A 278
ARG A 211
 None
 1.19A 5z6jA-5jlcA:
undetectable		 5z6jA-5jlcA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jpn COMPLEMENT C4-A
COMPLEMENT C4-A

(Homo sapiens;
Homo sapiens) 		PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF00207
(A2M)
PF01821
(ANATO)
PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl) 		3 MET A 352
ASP B 768
ARG B 743
 None
 0.98A 5z6jA-5jpnA:
undetectable		 5z6jA-5jpnA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lad PUTATIVE GTP-BINDING
PROTEIN

(Thermotoga
maritima) 		PF01926
(MMR_HSR1) 		3 MET A 369
ASP A 337
ARG A  10
 None
 1.05A 5z6jA-5ladA:
undetectable		 5z6jA-5ladA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lfd ALLANTOIN RACEMASE

(Pseudomonas
fluorescens) 		no annotation 3 MET A 144
ASP A 152
ARG A 193
 None
 1.13A 5z6jA-5lfdA:
undetectable		 5z6jA-5lfdA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lj3 PRE-MRNA-SPLICING
FACTOR BUD31

(Saccharomyces
cerevisiae) 		PF01125
(G10) 		3 MET L  53
ASP L  88
ARG L 123
 None
None
A  V  26 ( 4.8A)
 1.15A 5z6jA-5lj3L:
undetectable		 5z6jA-5lj3L:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mch CELLOBIOHYDROLASE
CHBI

(Daphnia pulex) 		PF00840
(Glyco_hydro_7) 		3 MET A 363
ASP A 286
ARG A 334
 None
 1.18A 5z6jA-5mchA:
undetectable		 5z6jA-5mchA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o7g ALPHA/BETA HYDROLASE
FAMILY PROTEIN

(Bacillus
coagulans) 		no annotation 3 MET A 177
ASP A 251
ARG A  44
 None
 0.94A 5z6jA-5o7gA:
undetectable		 5z6jA-5o7gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oyp STRUCTURAL PROTEIN
VP2
STRUCTURAL PROTEIN
VP3

(Sacbrood virus;
Sacbrood virus) 		no annotation
no annotation 		3 MET B 156
ASP C 121
ARG C 239
 None
 1.16A 5z6jA-5oypB:
undetectable		 5z6jA-5oypB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5txe ATXE2

(Asticcacaulis
excentricus) 		PF00326
(Peptidase_S9) 		3 MET A 307
ASP A 257
ARG A 272
 None
 1.09A 5z6jA-5txeA:
undetectable		 5z6jA-5txeA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yj4 MAJOR PRION PROTEIN

(Homo sapiens) 		no annotation 3 MET A 129
ASP A 167
ARG A 228
 None
 1.20A 5z6jA-5yj4A:
undetectable		 5z6jA-5yj4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5f NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE

(Yersinia
enterocolitica) 		no annotation 3 MET A  19
ASP A 282
ARG A  38
 None
 1.14A 5z6jA-6b5fA:
undetectable		 5z6jA-6b5fA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bac ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Neisseria
gonorrhoeae) 		no annotation 3 MET A 142
ASP A 112
ARG A  19
 None
 1.12A 5z6jA-6bacA:
undetectable		 5z6jA-6bacA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bzg SPORULATION-SPECIFIC
PROTEIN 16
PROTEIN ZIP2

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		no annotation
no annotation 		3 MET B 556
ASP B 594
ARG A 125
 None
 1.06A 5z6jA-6bzgB:
undetectable		 5z6jA-6bzgB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6l V-TYPE PROTON ATPASE
SUBUNIT D
V-TYPE PROTON ATPASE
SUBUNIT C'

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		no annotation
no annotation 		3 MET D 128
ASP B 298
ARG B  18
 None
 1.10A 5z6jA-6c6lD:
undetectable		 5z6jA-6c6lD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c93 CYTOCHROME P450 4B1

(Oryctolagus
cuniculus) 		no annotation 3 MET A 308
ASP A 203
ARG A 257
 None
 0.83A 5z6jA-6c93A:
undetectable		 5z6jA-6c93A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MBH SUBUNIT
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D
MBH SUBUNIT

(Pyrococcus
furiosus;
Pyrococcus
furiosus;
Pyrococcus
furiosus) 		no annotation
no annotation
no annotation 		3 MET H 233
ASP I  88
ARG E   3
 None
 0.98A 5z6jA-6cfwH:
undetectable		 5z6jA-6cfwH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT C
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D
MBH SUBUNIT

(Pyrococcus
furiosus;
Pyrococcus
furiosus;
Pyrococcus
furiosus) 		no annotation
no annotation
no annotation 		3 MET H 298
ASP I  88
ARG G 113
 None
 1.05A 5z6jA-6cfwH:
undetectable		 5z6jA-6cfwH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6em0 2-HYDROXYBIPHENYL-3-
MONOOXYGENASE

(Pseudomonas
nitroreducens) 		no annotation 3 MET A 558
ASP A 489
ARG A 114
 None
 1.19A 5z6jA-6em0A:
undetectable		 5z6jA-6em0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en4 SPLICING FACTOR 3B
SUBUNIT 3

(Homo sapiens) 		no annotation 3 MET A 285
ASP A 279
ARG A 429
 None
 1.00A 5z6jA-6en4A:
undetectable		 5z6jA-6en4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE

(Bacteroides
thetaiotaomicron) 		no annotation 3 MET A  54
ASP A 324
ARG A 379
 None
 1.21A 5z6jA-6f8zA:
undetectable		 5z6jA-6f8zA:
undetectable