SIMILAR PATTERNS OF AMINO ACIDS FOR 5Z12_B_9CRB501_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ak6 DESTRIN

(Homo sapiens;
Sus scrofa) 		PF00241
(Cofilin_ADF) 		3 GLN A 136
ILE A  55
HIS A  70
 None
 0.71A 5z12B-1ak6A:
undetectable		 5z12B-1ak6A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1amk TRIOSE PHOSPHATE
ISOMERASE

(Leishmania
mexicana) 		PF00121
(TIM) 		3 GLN A  52
ILE A 246
HIS A  31
 None
 0.61A 5z12B-1amkA:
undetectable		 5z12B-1amkA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1by7 PROTEIN (PLASMINOGEN
ACTIVATOR
INHIBITOR-2)

(Homo sapiens) 		PF00079
(Serpin) 		3 GLN A  59
ILE A 114
HIS A 400
 None
 0.58A 5z12B-1by7A:
0.0		 5z12B-1by7A:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		3 GLN A 157
ILE A 207
HIS A 205
 None
ZN  A 402 ( 4.8A)
ZN  A 402 (-3.4A)
 0.69A 5z12B-1fd9A:
undetectable		 5z12B-1fd9A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1khd ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Pectobacterium
carotovorum) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		3 GLN A  33
ILE A 194
HIS A 168
 None
 0.53A 5z12B-1khdA:
undetectable		 5z12B-1khdA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lg7 VSV MATRIX PROTEIN

(Vesicular
stomatitis
virus) 		PF06326
(Vesiculo_matrix) 		3 GLN A 128
ILE A 164
HIS A  90
 None
 0.70A 5z12B-1lg7A:
undetectable		 5z12B-1lg7A:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qrr SULFOLIPID
BIOSYNTHESIS (SQD1)
PROTEIN

(Arabidopsis
thaliana) 		PF01370
(Epimerase) 		3 GLN A 366
ILE A 376
HIS A 251
 None
 0.70A 5z12B-1qrrA:
0.0		 5z12B-1qrrA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sdd COAGULATION FACTOR V

(Bos taurus) 		PF07732
(Cu-oxidase_3) 		3 GLN A 246
ILE A 217
HIS A 183
 None
 0.67A 5z12B-1sddA:
undetectable		 5z12B-1sddA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 95 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF08519
(RFC1) 		3 GLN A 474
ILE A 422
HIS A 364
 None
 0.42A 5z12B-1sxjA:
undetectable		 5z12B-1sxjA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tk9 PHOSPHOHEPTOSE
ISOMERASE 1

(Campylobacter
jejuni) 		PF13580
(SIS_2) 		3 GLN A  19
ILE A 174
HIS A 178
 None
 0.68A 5z12B-1tk9A:
undetectable		 5z12B-1tk9A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tt4 PUTATIVE CYTOPLASMIC
PROTEIN

(Salmonella
enterica) 		PF04107
(GCS2) 		3 GLN A 258
ILE A 148
HIS A 152
 None
 0.68A 5z12B-1tt4A:
0.0		 5z12B-1tt4A:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tv8 MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A

(Staphylococcus
aureus) 		PF04055
(Radical_SAM)
PF06463
(Mob_synth_C)
PF13394
(Fer4_14) 		3 GLN A 249
ILE A 178
HIS A 223
 None
 0.64A 5z12B-1tv8A:
undetectable		 5z12B-1tv8A:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6g TIP120 PROTEIN

(Homo sapiens) 		PF08623
(TIP120) 		3 GLN C 544
ILE C 473
HIS C 516
 None
 0.70A 5z12B-1u6gC:
undetectable		 5z12B-1u6gC:
5.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uhl RETINOIC ACID
RECEPTOR RXR-BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		3 GLN A 346
ILE A 416
HIS A 506
 None
 0.57A 5z12B-1uhlA:
35.6		 5z12B-1uhlA:
80.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukr ENDO-1,4-B-XYLANASE
I

(Aspergillus
niger) 		PF00457
(Glyco_hydro_11) 		3 GLN A  77
ILE A  82
HIS A 148
 None
 0.68A 5z12B-1ukrA:
undetectable		 5z12B-1ukrA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wnh LATEXIN

(Mus musculus) 		PF06907
(Latexin) 		3 GLN A 150
ILE A 187
HIS A 185
 None
 0.48A 5z12B-1wnhA:
undetectable		 5z12B-1wnhA:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xiu RXR-LIKE PROTEIN

(Biomphalaria
glabrata) 		PF00104
(Hormone_recep) 		3 GLN A 249
ILE A 319
HIS A 409
 9CR  A 201 (-4.1A)
None
9CR  A 201 (-4.8A)
 0.39A 5z12B-1xiuA:
32.8		 5z12B-1xiuA:
73.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xls RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		3 GLN A 275
ILE A 345
HIS A 435
 9CR  A 801 (-4.7A)
9CR  A 801 ( 4.5A)
None
 0.49A 5z12B-1xlsA:
35.4		 5z12B-1xlsA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yb5 QUINONE
OXIDOREDUCTASE

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 GLN A 302
ILE A 316
HIS A 317
 None
 0.69A 5z12B-1yb5A:
undetectable		 5z12B-1yb5A:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zb1 BRO1 PROTEIN

(Saccharomyces
cerevisiae) 		PF03097
(BRO1) 		3 GLN A 130
ILE A 339
HIS A 182
 None
 0.69A 5z12B-1zb1A:
undetectable		 5z12B-1zb1A:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2akj FERREDOXIN--NITRITE
REDUCTASE,
CHLOROPLAST

(Spinacia
oleracea) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		3 GLN A 172
ILE A  86
HIS A  97
 None
 0.69A 5z12B-2akjA:
undetectable		 5z12B-2akjA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bo9 HUMAN LATEXIN

(Homo sapiens) 		PF06907
(Latexin) 		3 GLN B 150
ILE B 187
HIS B 185
 None
 0.64A 5z12B-2bo9B:
undetectable		 5z12B-2bo9B:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4e 5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
SEMIALDEHYDE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00171
(Aldedh) 		3 GLN A 116
ILE A 211
HIS A 102
 None
 0.67A 5z12B-2d4eA:
undetectable		 5z12B-2d4eA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dc0 PROBABLE AMIDASE

(Thermus
thermophilus) 		PF01425
(Amidase) 		3 GLN A 411
ILE A 228
HIS A 217
 None
 0.71A 5z12B-2dc0A:
undetectable		 5z12B-2dc0A:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dep THERMOSTABLE
CELLOXYLANASE

([Clostridium]
stercorarium) 		PF00331
(Glyco_hydro_10) 		3 GLN A 324
ILE A 279
HIS A 261
 None
 0.69A 5z12B-2depA:
undetectable		 5z12B-2depA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dlg FILAMIN-B

(Homo sapiens) 		PF00630
(Filamin) 		3 GLN A  86
ILE A  25
HIS A  57
 None
 0.69A 5z12B-2dlgA:
undetectable		 5z12B-2dlgA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f7v AECTYLCITRULLINE
DEACETYLASE

(Xanthomonas
campestris) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		3 GLN A  40
ILE A 104
HIS A  72
 None
CO  A5367 ( 4.7A)
CO  A5367 (-3.4A)
 0.56A 5z12B-2f7vA:
undetectable		 5z12B-2f7vA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hb6 LEUCINE
AMINOPEPTIDASE 1

(Caenorhabditis
elegans) 		PF00883
(Peptidase_M17) 		3 GLN A  43
ILE A  59
HIS A  65
 None
 0.61A 5z12B-2hb6A:
undetectable		 5z12B-2hb6A:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iir ACETATE KINASE

(Thermotoga
maritima) 		PF00871
(Acetate_kinase) 		3 GLN A 152
ILE A 130
HIS A  89
 None
 0.70A 5z12B-2iirA:
undetectable		 5z12B-2iirA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kvp TALIN-1

(Mus musculus) 		PF08913
(VBS) 		3 GLN A1888
ILE A1835
HIS A1925
 None
 0.68A 5z12B-2kvpA:
undetectable		 5z12B-2kvpA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lxn GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT A

(Methanocaldococcus
jannaschii) 		PF00117
(GATase) 		3 GLN A 146
ILE A  75
HIS A 163
 None
 0.64A 5z12B-2lxnA:
undetectable		 5z12B-2lxnA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w0m SSO2452

(Sulfolobus
solfataricus) 		PF06745
(ATPase) 		3 GLN A  17
ILE A 227
HIS A  42
 None
 0.68A 5z12B-2w0mA:
undetectable		 5z12B-2w0mA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1j PUTATIVE SORTASE

(Streptococcus
pneumoniae) 		PF04203
(Sortase) 		3 GLN A 106
ILE A  22
HIS A  84
 None
 0.69A 5z12B-2w1jA:
undetectable		 5z12B-2w1jA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 GLN A 749
ILE A 639
HIS A 621
 None
 0.57A 5z12B-3c4fA:
undetectable		 5z12B-3c4fA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3col PUTATIVE
TRANSCRIPTION
REGULATOR

(Lactobacillus
plantarum) 		PF00440
(TetR_N) 		3 GLN A  92
ILE A 144
HIS A 152
 None
 0.67A 5z12B-3colA:
undetectable		 5z12B-3colA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dpu RAB FAMILY PROTEIN

(Chlorobaculum
tepidum) 		PF08477
(Roc)
PF16095
(COR) 		3 GLN A 762
ILE A 703
HIS A 699
 None
 0.67A 5z12B-3dpuA:
undetectable		 5z12B-3dpuA:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3duh INTERLEUKIN-23
SUBUNIT ALPHA

(Homo sapiens) 		PF16649
(IL23) 		3 GLN C 151
ILE C  79
HIS C  75
 None
 0.67A 5z12B-3duhC:
undetectable		 5z12B-3duhC:
17.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		3 GLN A 275
ILE A 345
HIS A 435
 9CR  A7223 (-4.6A)
9CR  A7223 ( 4.9A)
9CR  A7223 (-4.3A)
 0.38A 5z12B-3dzuA:
33.8		 5z12B-3dzuA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb6 BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 3

(Homo sapiens) 		PF13920
(zf-C3HC4_3) 		3 GLN A 552
ILE A 590
HIS A 574
 None
ZN  A1002 ( 4.9A)
ZN  A1002 (-2.8A)
 0.62A 5z12B-3eb6A:
undetectable		 5z12B-3eb6A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eo7 PUTATIVE
NITROREDUCTASE

(Trichormus
variabilis) 		PF00881
(Nitroreductase) 		3 GLN A 144
ILE A 246
HIS A 207
 None
 0.64A 5z12B-3eo7A:
undetectable		 5z12B-3eo7A:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3euw MYO-INOSITOL
DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		3 GLN A  41
ILE A  13
HIS A  17
 None
 0.61A 5z12B-3euwA:
undetectable		 5z12B-3euwA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwj ARYLPHORIN

(Antheraea
pernyi) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 GLN A 652
ILE A 552
HIS A 543
 None
 0.58A 5z12B-3gwjA:
undetectable		 5z12B-3gwjA:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hs0 COBRA VENOM FACTOR

(Naja kaouthia) 		PF00207
(A2M) 		3 GLN B 847
ILE B 813
HIS B 815
 None
 0.65A 5z12B-3hs0B:
undetectable		 5z12B-3hs0B:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica) 		PF03063
(Prismane) 		3 GLN A 389
ILE A 356
HIS A 281
 None
 0.71A 5z12B-3i04A:
undetectable		 5z12B-3i04A:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jys SUSD SUPERFAMILY
PROTEIN

(Bacteroides
vulgatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 GLN A  91
ILE A 367
HIS A 338
 None
 0.70A 5z12B-3jysA:
undetectable		 5z12B-3jysA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kpt COLLAGEN ADHESION
PROTEIN

(Bacillus cereus) 		no annotation 3 GLN A 222
ILE A 173
HIS A 208
 None
 0.70A 5z12B-3kptA:
undetectable		 5z12B-3kptA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lca PROTEIN TOM71

(Saccharomyces
cerevisiae) 		PF00515
(TPR_1)
PF13181
(TPR_8)
PF14559
(TPR_19) 		3 GLN A 395
ILE A 382
HIS A 417
 None
 0.68A 5z12B-3lcaA:
undetectable		 5z12B-3lcaA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m2t PROBABLE
DEHYDROGENASE

(Chromobacterium
violaceum) 		PF01408
(GFO_IDH_MocA) 		3 GLN A  25
ILE A  52
HIS A  46
 None
None
SO4  A 359 (-3.6A)
 0.70A 5z12B-3m2tA:
undetectable		 5z12B-3m2tA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mes CHOLINE KINASE

(Cryptosporidium
parvum) 		PF01633
(Choline_kinase) 		3 GLN A  77
ILE A 140
HIS A 102
 None
 0.71A 5z12B-3mesA:
undetectable		 5z12B-3mesA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmk FUSION OF
LIM/HOMEOBOX PROTEIN
LHX4, LINKER,
INSULIN GENE
ENHANCER PROTEIN
ISL-2

(Mus musculus) 		PF00412
(LIM) 		3 GLN A 106
ILE A  96
HIS A 283
 None
 0.70A 5z12B-3mmkA:
undetectable		 5z12B-3mmkA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3moi PROBABLE
DEHYDROGENASE

(Bordetella
bronchiseptica) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		3 GLN A 341
ILE A 352
HIS A  90
 None
 0.71A 5z12B-3moiA:
undetectable		 5z12B-3moiA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nby SNURPORTIN-1

(Homo sapiens) 		PF11538
(Snurportin1) 		3 GLN B  15
ILE B 108
HIS B  24
 None
 0.70A 5z12B-3nbyB:
undetectable		 5z12B-3nbyB:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3no8 BTB/POZ
DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF08005
(PHR) 		3 GLN A 419
ILE A 412
HIS A 413
 None
 0.61A 5z12B-3no8A:
undetectable		 5z12B-3no8A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3no8 BTB/POZ
DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF08005
(PHR) 		3 GLN A 419
ILE A 412
HIS A 477
 None
 0.58A 5z12B-3no8A:
undetectable		 5z12B-3no8A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ocj PUTATIVE EXPORTED
PROTEIN

(Bordetella
parapertussis) 		PF13847
(Methyltransf_31) 		3 GLN A 212
ILE A 297
HIS A 112
 None
 0.71A 5z12B-3ocjA:
undetectable		 5z12B-3ocjA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3okf 3-DEHYDROQUINATE
SYNTHASE

(Vibrio cholerae) 		PF01761
(DHQ_synthase) 		3 GLN A 130
ILE A  58
HIS A  68
 None
 0.58A 5z12B-3okfA:
undetectable		 5z12B-3okfA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3prx COBRA VENOM FACTOR

(Naja kaouthia) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		3 GLN B 869
ILE B 835
HIS B 837
 None
 0.56A 5z12B-3prxB:
undetectable		 5z12B-3prxB:
4.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q2k OXIDOREDUCTASE

(Bordetella
pertussis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		3 GLN A  50
ILE A  21
HIS A  25
 None
NAI  A 500 (-3.6A)
None
 0.67A 5z12B-3q2kA:
undetectable		 5z12B-3q2kA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Coxiella
burnetii) 		PF00275
(EPSP_synthase) 		3 GLN A 169
ILE A 228
HIS A 203
 PO4  A 442 ( 4.1A)
None
None
 0.52A 5z12B-3tr1A:
undetectable		 5z12B-3tr1A:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr7 URACIL-DNA
GLYCOSYLASE

(Coxiella
burnetii) 		PF03167
(UDG) 		3 GLN A 175
ILE A  59
HIS A 157
 None
 0.56A 5z12B-3tr7A:
undetectable		 5z12B-3tr7A:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 GLN A 749
ILE A 639
HIS A 621
 None
 0.69A 5z12B-3tt0A:
undetectable		 5z12B-3tt0A:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uaf TTR-52

(Caenorhabditis
elegans) 		PF01060
(TTR-52) 		3 GLN A  73
ILE A 108
HIS A  95
 None
 0.63A 5z12B-3uafA:
undetectable		 5z12B-3uafA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vil BETA-GLUCOSIDASE

(Neotermes
koshunensis) 		PF00232
(Glyco_hydro_1) 		3 GLN A 316
ILE A 285
HIS A 229
 None
 0.70A 5z12B-3vilA:
undetectable		 5z12B-3vilA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3voc BETA/ALPHA-AMYLASE

(Paenibacillus
polymyxa) 		PF01373
(Glyco_hydro_14) 		3 GLN A 132
ILE A 276
HIS A 265
 CA  A 501 (-2.9A)
None
EDO  A 505 ( 4.2A)
 0.71A 5z12B-3vocA:
undetectable		 5z12B-3vocA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13

(Mycobacterium
tuberculosis) 		PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N) 		3 GLN A 168
ILE A 156
HIS A 213
 None
 0.69A 5z12B-3zukA:
undetectable		 5z12B-3zukA:
8.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4arp PESTICIN

(Yersinia pestis) 		PF16754
(Pesticin) 		3 GLN A 301
ILE A 166
HIS A 269
 None
 0.68A 5z12B-4arpA:
undetectable		 5z12B-4arpA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eei ADENYLOSUCCINATE
LYASE

(Francisella
tularensis) 		PF00206
(Lyase_1) 		3 GLN A  52
ILE A  97
HIS A  89
 None
 0.67A 5z12B-4eeiA:
undetectable		 5z12B-4eeiA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ege DIPEPTIDASE PEPE

(Mycobacterium
ulcerans) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		3 GLN A 142
ILE A 308
HIS A 306
 None
None
ZN  A 411 (-3.3A)
 0.69A 5z12B-4egeA:
undetectable		 5z12B-4egeA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f52 E3 UBIQUITIN-PROTEIN
LIGASE RBX1
GLOMULIN

(Homo sapiens) 		PF08568
(Kinetochor_Ybp2)
PF12678
(zf-rbx1) 		3 GLN E 427
ILE B  37
HIS E 413
 None
 0.70A 5z12B-4f52E:
undetectable		 5z12B-4f52E:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fhn NUCLEOPORIN NUP120

(Schizosaccharomyces
pombe) 		PF11715
(Nup160) 		3 GLN B 267
ILE B 195
HIS B 204
 None
 0.62A 5z12B-4fhnB:
undetectable		 5z12B-4fhnB:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g56 HSL7 PROTEIN

(Xenopus laevis) 		PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		3 GLN A 259
ILE A 231
HIS A 246
 None
 0.59A 5z12B-4g56A:
undetectable		 5z12B-4g56A:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ggj MITOCHONDRIAL
CARDIOLIPIN
HYDROLASE

(Mus musculus) 		PF13091
(PLDc_2) 		3 GLN A 102
ILE A 141
HIS A 111
 None
 0.62A 5z12B-4ggjA:
undetectable		 5z12B-4ggjA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gnj TRIOSEPHOSPHATE
ISOMERASE

(Leishmania sp.
'siamensis') 		PF00121
(TIM) 		3 GLN A  53
ILE A 247
HIS A  32
 None
 0.53A 5z12B-4gnjA:
undetectable		 5z12B-4gnjA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gqb PROTEIN ARGININE
N-METHYLTRANSFERASE
5

(Homo sapiens) 		PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		3 GLN A 263
ILE A 235
HIS A 250
 None
 0.57A 5z12B-4gqbA:
undetectable		 5z12B-4gqbA:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j35 PHOSPHOTRIESTERASE,
PUTATIVE

(Deinococcus
radiodurans) 		PF02126
(PTE) 		3 GLN A  62
ILE A 296
HIS A 291
 None
 0.68A 5z12B-4j35A:
undetectable		 5z12B-4j35A:
13.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4j5x RETINOIC ACID
RECEPTOR RXR-ALPHA,
NUCLEAR RECEPTOR
COACTIVATOR 1

(Homo sapiens) 		no annotation 3 GLN D 275
ILE D 345
HIS D 435
 None
 0.50A 5z12B-4j5xD:
34.2		 5z12B-4j5xD:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jc8 HOPS COMPONENT VPS33

(Chaetomium
thermophilum) 		PF00995
(Sec1) 		3 GLN A 464
ILE A 651
HIS A 453
 None
 0.70A 5z12B-4jc8A:
undetectable		 5z12B-4jc8A:
7.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4or8 MEMBRANE-ASSOCIATED
PROTEIN VP24

(Marburg
marburgvirus) 		PF06389
(Filo_VP24) 		3 GLN A  71
ILE A  87
HIS A  58
 None
 0.68A 5z12B-4or8A:
undetectable		 5z12B-4or8A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8g UNCONVENTIONAL
MYOSIN-IC

(Mus musculus) 		PF00612
(IQ)
PF06017
(Myosin_TH1) 		3 GLN E 960
ILE E 999
HIS E1017
 None
 0.64A 5z12B-4r8gE:
undetectable		 5z12B-4r8gE:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		3 GLN A 356
ILE A 321
HIS A 432
 None
 0.65A 5z12B-4w8jA:
undetectable		 5z12B-4w8jA:
5.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhy FLAVIN REDUCTASE
DOMAIN PROTEIN,
FMN-BINDING PROTEIN

(Paracoccus
denitrificans) 		PF01613
(Flavin_Reduct) 		3 GLN A 175
ILE A 126
HIS A  91
 None
 0.68A 5z12B-4xhyA:
undetectable		 5z12B-4xhyA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ywe PUTATIVE ALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		3 GLN A 255
ILE A 344
HIS A 375
 None
 0.63A 5z12B-4yweA:
undetectable		 5z12B-4yweA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0c TOLL-LIKE RECEPTOR
13

(Mus musculus) 		PF00560
(LRR_1)
PF13516
(LRR_6)
PF13855
(LRR_8) 		3 GLN A 698
ILE A 710
HIS A 714
 None
 0.48A 5z12B-4z0cA:
undetectable		 5z12B-4z0cA:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zg5 5'-NUCLEOTIDASE SURE

(Brucella
abortus) 		no annotation 3 GLN D 125
ILE D  11
HIS D  12
 None
 0.70A 5z12B-4zg5D:
undetectable		 5z12B-4zg5D:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF

(Serratia sp.
FS14) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		3 GLN A 175
ILE A 126
HIS A  48
 None
None
ZN  A 801 (-3.2A)
 0.53A 5z12B-5cioA:
undetectable		 5z12B-5cioA:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF

(Serratia sp.
FS14) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		3 GLN A 175
ILE A 126
HIS A  52
 None
None
ZN  A 801 (-3.2A)
 0.52A 5z12B-5cioA:
undetectable		 5z12B-5cioA:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dis SNURPORTIN-1

(Homo sapiens) 		PF11538
(Snurportin1) 		3 GLN C  16
ILE C 109
HIS C  25
 None
 0.62A 5z12B-5disC:
undetectable		 5z12B-5disC:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5edx CD8 ALPHA ANTIGEN

(Sus scrofa) 		PF07686
(V-set) 		3 GLN A  11
ILE A  80
HIS A  82
 None
 0.68A 5z12B-5edxA:
undetectable		 5z12B-5edxA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exr DNA PRIMASE LARGE
SUBUNIT

(Homo sapiens) 		PF04104
(DNA_primase_lrg) 		3 GLN B 446
ILE B 276
HIS B 292
 None
 0.68A 5z12B-5exrB:
undetectable		 5z12B-5exrB:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h11 UNCHARACTERIZED
PROTEIN

(Danio rerio) 		PF07393
(Sec10) 		3 GLN A 620
ILE A 632
HIS A 658
 None
 0.68A 5z12B-5h11A:
undetectable		 5z12B-5h11A:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h42 UNCHARACTERIZED
PROTEIN

(Lachnoclostridium
phytofermentans) 		PF17167
(Glyco_hydro_36) 		3 GLN A 144
ILE A 252
HIS A 248
 None
 0.68A 5z12B-5h42A:
undetectable		 5z12B-5h42A:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k3h ACYL-COENZYME A
OXIDASE

(Caenorhabditis
elegans) 		PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N) 		3 GLN A 355
ILE A 488
HIS A 568
 None
 0.53A 5z12B-5k3hA:
undetectable		 5z12B-5k3hA:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbc DSBA

(Chlamydia
trachomatis) 		PF13462
(Thioredoxin_4) 		3 GLN A 149
ILE A 137
HIS A  88
 None
 0.71A 5z12B-5kbcA:
undetectable		 5z12B-5kbcA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lwg VP3

(Israeli acute
paralysis virus) 		no annotation 3 GLN C  78
ILE C  91
HIS C  67
 None
 0.63A 5z12B-5lwgC:
undetectable		 5z12B-5lwgC:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tjt MAJOR CAPSID PROTEIN

(Escherichia
virus T5) 		PF05065
(Phage_capsid) 		3 GLN A 187
ILE A 283
HIS A 279
 None
 0.66A 5z12B-5tjtA:
undetectable		 5z12B-5tjtA:
15.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uan RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		no annotation 3 GLN A 275
ILE A 345
HIS A 435
 9CR  A 503 (-3.8A)
None
None
 0.43A 5z12B-5uanA:
34.4		 5z12B-5uanA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uki RNA LARIAT
DEBRANCHING ENZYME,
PUTATIVE

(Entamoeba
histolytica) 		no annotation 3 GLN A 184
ILE A 245
HIS A 236
 None
 0.60A 5z12B-5ukiA:
undetectable		 5z12B-5ukiA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v7q 50S RIBOSOMAL
PROTEIN L19

(Mycobacterium
tuberculosis) 		PF01245
(Ribosomal_L19) 		3 GLN P  40
ILE P  16
HIS P  76
 None
 0.60A 5z12B-5v7qP:
undetectable		 5z12B-5v7qP:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cet GATOR COMPLEX
PROTEIN NPRL2
GATOR COMPLEX
PROTEIN NPRL3

(Homo sapiens) 		no annotation 3 GLN N 240
ILE N 206
HIS M 518
 None
 0.56A 5z12B-6cetN:
undetectable		 5z12B-6cetN:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmn TAR-BINDING PROTEIN
6.7

(Oryctolagus
cuniculus) 		no annotation 3 GLN A  54
ILE A  40
HIS A  31
 A  D  35 ( 2.9A)
None
None
 0.60A 5z12B-6cmnA:
undetectable		 5z12B-6cmnA:
15.66