SIMILAR PATTERNS OF AMINO ACIDS FOR 5Z12_B_9CRB501_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1csj | HEPATITIS C VIRUSRNA POLYMERASE(NS5B) (Hepacivirus C) |
PF00998(RdRP_3) | 5 | ALA A 249ALA A 174LEU A 245ALA A 246LEU A 285 | None | 0.94A | 5z12B-1csjA:undetectable | 5z12B-1csjA:10.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e19 | CARBAMATE KINASE (Pyrococcusfuriosus) |
PF00696(AA_kinase) | 6 | ILE A 37ALA A 34LEU A 97ALA A 96VAL A 5LEU A 234 | None | 0.91A | 5z12B-1e19A:undetectable | 5z12B-1e19A:12.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fc4 | 2-AMINO-3-KETOBUTYRATE CONENZYME ALIGASE (Escherichiacoli) |
PF00155(Aminotran_1_2) | 5 | ILE A 238ALA A 255ALA A 256LEU A 100ALA A 97 | None | 0.91A | 5z12B-1fc4A:undetectable | 5z12B-1fc4A:11.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gxn | PECTATE LYASE (Cellvibriojaponicus) |
PF09492(Pec_lyase) | 5 | ILE A 552ALA A 555LEU A 540LEU A 496LEU A 331 | None | 0.91A | 5z12B-1gxnA:undetectable | 5z12B-1gxnA:13.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hg4 | ULTRASPIRACLE (Drosophilamelanogaster) |
PF00104(Hormone_recep) | 5 | TRP A 318LEU A 322VAL A 382CYH A 472LEU A 476 | NoneLPP A 1 ( 4.8A)LPP A 1 (-4.8A)LPP A 1 ( 4.2A)LPP A 1 (-4.2A) | 0.59A | 5z12B-1hg4A:24.7 | 5z12B-1hg4A:14.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hg4 | ULTRASPIRACLE (Drosophilamelanogaster) |
PF00104(Hormone_recep) | 5 | TRP A 318LEU A 366VAL A 382CYH A 472LEU A 476 | NoneLPP A 1 ( 4.4A)LPP A 1 (-4.8A)LPP A 1 ( 4.2A)LPP A 1 (-4.2A) | 0.67A | 5z12B-1hg4A:24.7 | 5z12B-1hg4A:14.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1iqr | PHOTOLYASE (Thermusthermophilus) |
PF00875(DNA_photolyase)PF03441(FAD_binding_7) | 6 | ALA A 227ALA A 226LEU A 225LEU A 124ALA A 146LEU A 212 | None | 1.18A | 5z12B-1iqrA:undetectable | 5z12B-1iqrA:11.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j0h | NEOPULLULANASE (Geobacillusstearothermophilus) |
PF00128(Alpha-amylase)PF02903(Alpha-amylase_N)PF16657(Malt_amylase_C) | 5 | ILE A 428ALA A 388LEU A 441LEU A 384LEU A 486 | None | 0.87A | 5z12B-1j0hA:undetectable | 5z12B-1j0hA:7.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lv7 | FTSH (Escherichiacoli) |
PF00004(AAA) | 6 | ILE A 253ALA A 298LEU A 306ALA A 299VAL A 236LEU A 282 | None | 1.40A | 5z12B-1lv7A:undetectable | 5z12B-1lv7A:14.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1n60 | CARBON MONOXIDEDEHYDROGENASE SMALLCHAIN (Oligotrophacarboxidovorans) |
PF00111(Fer2)PF01799(Fer2_2) | 5 | ILE A 149ALA A 152ALA A 153LEU A 90ALA A 89 | None | 0.92A | 5z12B-1n60A:undetectable | 5z12B-1n60A:16.88 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1pcg | ESTROGEN RECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 6 | ALA A 350TRP A 383LEU A 387ARG A 394VAL A 418LEU A 525 | EST A 1 ( 3.7A)NoneEST A 1 (-4.0A)EST A 1 (-3.7A)NoneEST A 1 (-3.6A) | 0.92A | 5z12B-1pcgA:25.8 | 5z12B-1pcgA:35.48 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1r20 | ULTRASPIRACLEPROTEIN (Heliothisvirescens) |
PF00104(Hormone_recep) | 5 | TRP A 286ARG A 297LEU A 325VAL A 341LEU A 435 | NoneNoneNoneEPH A4000 (-4.9A)EPH A4000 ( 4.6A) | 0.66A | 5z12B-1r20A:24.3 | 5z12B-1r20A:40.70 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1r20 | ULTRASPIRACLEPROTEIN (Heliothisvirescens) |
PF00104(Hormone_recep) | 5 | TRP A 286LEU A 290ARG A 297LEU A 325LEU A 435 | NoneEPH A4000 ( 4.8A)NoneNoneEPH A4000 ( 4.6A) | 0.98A | 5z12B-1r20A:24.3 | 5z12B-1r20A:40.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tdj | BIOSYNTHETICTHREONINE DEAMINASE (Escherichiacoli) |
PF00291(PALP)PF00585(Thr_dehydrat_C) | 6 | ILE A 270ALA A 294ALA A 273LEU A 277LEU A 291ALA A 292 | None | 1.42A | 5z12B-1tdjA:undetectable | 5z12B-1tdjA:10.63 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1uhl | RETINOIC ACIDRECEPTOR RXR-BETA (Homo sapiens) |
PF00104(Hormone_recep) | 12 | ILE A 339ALA A 342ALA A 343TRP A 376LEU A 380PHE A 384ARG A 387LEU A 397ALA A 398VAL A 413CYH A 503LEU A 507 | MEI A1001 (-3.8A)MEI A1001 (-3.1A)MEI A1001 (-3.3A)NoneMEI A1001 (-3.8A)MEI A1001 (-4.5A)MEI A1001 (-3.6A)MEI A1001 ( 4.4A)MEI A1001 (-3.4A)MEI A1001 (-4.1A)MEI A1001 (-4.0A)MEI A1001 (-4.6A) | 0.55A | 5z12B-1uhlA:35.6 | 5z12B-1uhlA:80.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vdl | UBIQUITINCARBOXYL-TERMINALHYDROLASE 25 (Mus musculus) |
PF14555(UBA_4) | 5 | ILE A 42ALA A 46LEU A 28LEU A 61ALA A 57 | None | 0.95A | 5z12B-1vdlA:undetectable | 5z12B-1vdlA:17.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wra | TEICHOIC ACIDPHOSPHORYLCHOLINEESTERASE/CHOLINEBINDING PROTEIN E(CBPE) (Streptococcuspneumoniae) |
PF00753(Lactamase_B) | 5 | ILE A 47ALA A 45LEU A 87VAL A 100LEU A 122 | None | 0.94A | 5z12B-1wraA:undetectable | 5z12B-1wraA:12.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xa0 | PUTATIVE NADPHDEPENDENTOXIDOREDUCTASES (Geobacillusstearothermophilus) |
PF00107(ADH_zinc_N) | 5 | ALA A 134ALA A 135LEU A 291LEU A 165ALA A 166 | None | 0.88A | 5z12B-1xa0A:undetectable | 5z12B-1xa0A:13.10 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1xiu | RXR-LIKE PROTEIN (Biomphalariaglabrata) |
PF00104(Hormone_recep) | 12 | ILE A 242ALA A 245ALA A 246TRP A 279LEU A 283PHE A 287ARG A 290LEU A 300ALA A 301VAL A 316CYH A 406LEU A 410 | 9CR A 201 ( 4.4A)9CR A 201 (-3.6A)9CR A 201 (-3.6A)None9CR A 201 ( 4.1A)9CR A 201 (-4.7A)9CR A 201 (-2.8A)9CR A 201 (-4.4A)9CR A 201 (-3.4A)9CR A 201 (-4.2A)9CR A 201 (-3.6A)9CR A 201 ( 4.8A) | 0.36A | 5z12B-1xiuA:32.8 | 5z12B-1xiuA:73.49 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1xls | RETINOIC ACIDRECEPTOR RXR-ALPHA (Homo sapiens) |
PF00104(Hormone_recep) | 12 | ILE A 268ALA A 271ALA A 272TRP A 305LEU A 309PHE A 313ARG A 316LEU A 326ALA A 327VAL A 342CYH A 432LEU A 436 | 9CR A 801 (-3.9A)9CR A 801 (-3.6A)9CR A 801 (-3.5A)None9CR A 801 (-4.2A)9CR A 801 (-4.3A)9CR A 801 (-2.6A)9CR A 801 (-4.1A)9CR A 801 (-3.3A)9CR A 801 ( 4.3A)9CR A 801 ( 3.7A)9CR A 801 (-4.7A) | 0.33A | 5z12B-1xlsA:35.4 | 5z12B-1xlsA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1z5x | ULTRASPIRACLEPROTEIN (USP) AHOMOLOGUE OF RXR (Bemisia tabaci) |
PF00104(Hormone_recep) | 5 | ILE U 303ALA U 306ALA U 307LEU U 365ALA U 362 | None | 0.91A | 5z12B-1z5xU:22.0 | 5z12B-1z5xU:48.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bib | TEICHOIC ACIDPHOSPHORYLCHOLINEESTERASE/ CHOLINEBINDING PROTEIN (Streptococcuspneumoniae) |
PF00753(Lactamase_B)PF01473(CW_binding_1) | 5 | ILE A 22ALA A 20LEU A 62VAL A 75LEU A 97 | None | 0.95A | 5z12B-2bibA:undetectable | 5z12B-2bibA:8.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dpn | GLYCEROL KINASE (Thermusthermophilus) |
PF00370(FGGY_N)PF02782(FGGY_C) | 6 | ALA A 57ALA A 58LEU A 5ALA A 29VAL A 163LEU A 171 | None | 1.04A | 5z12B-2dpnA:undetectable | 5z12B-2dpnA:9.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gjm | LACTOPEROXIDASE (Bubalus bubalis) |
PF03098(An_peroxidase) | 6 | ILE A 478LEU A 467ARG A 426LEU A 422ALA A 61LEU A 460 | None | 1.27A | 5z12B-2gjmA:undetectable | 5z12B-2gjmA:10.10 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2gl8 | RETINOIC ACIDRECEPTOR RXR-GAMMA (Homo sapiens) |
PF00104(Hormone_recep) | 8 | TRP A 84LEU A 88PHE A 92ARG A 95LEU A 105ALA A 106VAL A 121CYH A 211 | None | 0.72A | 5z12B-2gl8A:27.7 | 5z12B-2gl8A:83.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hxo | PUTATIVE TETR-FAMILYTRANSCRIPTIONALREGULATOR (Streptomycescoelicolor) |
PF00440(TetR_N)PF02909(TetR_C) | 5 | ILE A 20ALA A 23ALA A 24LEU A 36LEU A 45 | None | 0.98A | 5z12B-2hxoA:undetectable | 5z12B-2hxoA:20.09 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2nxx | ULTRASPIRACLE (USP,NR2B4) (Triboliumcastaneum) |
PF00104(Hormone_recep) | 6 | LEU A 255PHE A 259ARG A 262LEU A 272ALA A 273CYH A 378 | None | 0.96A | 5z12B-2nxxA:25.4 | 5z12B-2nxxA:52.81 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ocf | ESTROGEN RECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 6 | ALA A 350TRP A 383LEU A 387ARG A 394VAL A 418LEU A 525 | EST A 596 ( 3.9A)NoneEST A 596 ( 4.2A)EST A 596 (-4.0A)CME A 417 ( 3.2A)EST A 596 (-3.6A) | 0.94A | 5z12B-2ocfA:25.9 | 5z12B-2ocfA:33.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ptz | ENOLASE (Trypanosomabrucei) |
PF00113(Enolase_C)PF03952(Enolase_N) | 5 | ILE A 116ALA A 119ALA A 120LEU A 83LEU A 135 | None | 0.97A | 5z12B-2ptzA:undetectable | 5z12B-2ptzA:15.85 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2q60 | RETINOID X RECEPTOR (Polyandrocarpamisakiensis) |
PF00104(Hormone_recep) | 7 | TRP A 180LEU A 184PHE A 188ARG A 191ALA A 202VAL A 217CYH A 307 | None | 0.55A | 5z12B-2q60A:26.8 | 5z12B-2q60A:51.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qpm | CYTOKININDEHYDROGENASE 1 (Zea mays) |
PF01565(FAD_binding_4)PF09265(Cytokin-bind) | 5 | ILE A 315ALA A 313LEU A 301ALA A 302VAL A 360 | None | 0.97A | 5z12B-2qpmA:undetectable | 5z12B-2qpmA:11.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vml | PHYCOCYANIN ALPHACHAINPHYCOCYANIN BETACHAIN (Gloeobacterviolaceus) |
PF00502(Phycobilisome) | 5 | ALA A 40ALA A 41ALA A 150VAL B 31LEU B 24 | None | 0.92A | 5z12B-2vmlA:undetectable | 5z12B-2vmlA:16.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w1z | ROP2 (Toxoplasmagondii) |
PF14531(Kinase-like) | 5 | ILE A 394ALA A 397ALA A 398LEU A 532LEU A 476 | None | 0.82A | 5z12B-2w1zA:undetectable | 5z12B-2w1zA:11.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xax | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1SUBUNIT ALPHA (Escherichiacoli) |
PF00317(Ribonuc_red_lgN)PF02867(Ribonuc_red_lgC)PF03477(ATP-cone) | 5 | ILE A 62ALA A 66ALA A 65LEU A 84ALA A 81 | None | 0.96A | 5z12B-2xaxA:undetectable | 5z12B-2xaxA:7.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xgo | XCOGT (Xanthomonascampestris) |
PF13432(TPR_16)PF13844(Glyco_transf_41) | 5 | ALA A 549PHE A 228LEU A 231ALA A 230LEU A 328 | None | 0.98A | 5z12B-2xgoA:undetectable | 5z12B-2xgoA:8.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y7c | GENE 0.3 PROTEIN (Escherichiavirus T7) |
PF08684(ocr) | 5 | ILE D 33ALA D 36ALA D 37LEU D 85LEU D 14 | None | 0.82A | 5z12B-2y7cD:undetectable | 5z12B-2y7cD:20.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3afg | SUBTILISIN-LIKESERINE PROTEASE (Thermococcuskodakarensis) |
PF00082(Peptidase_S8)PF04151(PPC) | 5 | ILE A 368ALA A 415ALA A 416LEU A 388ALA A 387 | None | 0.90A | 5z12B-3afgA:undetectable | 5z12B-3afgA:8.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3am6 | RHODOPSIN-2 (Acetabulariaacetabulum) |
PF01036(Bac_rhodopsin) | 5 | ILE A 44ALA A 47VAL A 95CYH A 218LEU A 219 | NoneNoneNoneNoneCLR A 401 ( 4.6A) | 0.97A | 5z12B-3am6A:undetectable | 5z12B-3am6A:15.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3djc | TYPE IIIPANTOTHENATE KINASE (Legionellapneumophila) |
PF03309(Pan_kinase) | 5 | ALA A 115ALA A 116LEU A 220VAL A 105CYH A 137 | None | 0.90A | 5z12B-3djcA:undetectable | 5z12B-3djcA:16.60 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3dzu | RETINOIC ACIDRECEPTOR RXR-ALPHA (Homo sapiens) |
PF00104(Hormone_recep)PF00105(zf-C4) | 12 | ILE A 268ALA A 271ALA A 272TRP A 305LEU A 309PHE A 313ARG A 316LEU A 326ALA A 327VAL A 342CYH A 432LEU A 436 | 9CR A7223 (-3.9A)9CR A7223 (-3.5A)9CR A7223 (-4.2A)None9CR A7223 ( 4.4A)9CR A7223 (-4.5A)9CR A7223 (-3.7A)9CR A7223 (-3.8A)9CR A7223 ( 4.7A)9CR A7223 ( 4.5A)9CR A7223 (-3.8A)9CR A7223 ( 4.7A) | 0.60A | 5z12B-3dzuA:33.8 | 5z12B-3dzuA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3eyb | NUCLEAR HORMONERECEPTOR RXR (Branchiostomafloridae) |
PF00104(Hormone_recep) | 5 | LEU A 338PHE A 342ALA A 356VAL A 371CYH A 461 | None | 0.85A | 5z12B-3eybA:28.4 | 5z12B-3eybA:75.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h0g | DNA-DIRECTED RNAPOLYMERASE IISUBUNIT RPB11DNA-DIRECTED RNAPOLYMERASE IISUBUNIT RPB3 (Schizosaccharomycespombe) |
PF01000(RNA_pol_A_bac)PF01193(RNA_pol_L)PF13656(RNA_pol_L_2) | 5 | ILE K 86ALA K 89ALA K 90LEU C 256LEU K 49 | None | 0.95A | 5z12B-3h0gK:undetectable | 5z12B-3h0gK:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hve | GIGAXONIN (Homo sapiens) |
PF00651(BTB)PF07707(BACK) | 5 | ILE A 47ALA A 50ALA A 51LEU B 20ALA B 19 | None | 0.68A | 5z12B-3hveA:undetectable | 5z12B-3hveA:16.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hve | GIGAXONIN (Homo sapiens) |
PF00651(BTB)PF07707(BACK) | 5 | ILE A 47ALA A 50LEU B 20ALA B 19LEU A 87 | None | 0.75A | 5z12B-3hveA:undetectable | 5z12B-3hveA:16.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hve | GIGAXONIN (Homo sapiens) |
PF00651(BTB)PF07707(BACK) | 5 | ILE B 47ALA B 50ALA B 51LEU A 20ALA A 19 | None | 0.71A | 5z12B-3hveB:undetectable | 5z12B-3hveB:14.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hve | GIGAXONIN (Homo sapiens) |
PF00651(BTB)PF07707(BACK) | 5 | ILE B 47ALA B 50LEU A 20ALA A 19LEU B 87 | None | 0.93A | 5z12B-3hveB:undetectable | 5z12B-3hveB:14.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ic5 | PUTATIVESACCHAROPINEDEHYDROGENASE (Ruegeriapomeroyi) |
PF03435(Sacchrp_dh_NADP) | 5 | ILE A 82ALA A 85ALA A 86LEU A 60ALA A 61 | None | 0.84A | 5z12B-3ic5A:undetectable | 5z12B-3ic5A:20.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ktc | XYLOSE ISOMERASE (Pectobacteriumatrosepticum) |
PF01261(AP_endonuc_2) | 5 | ILE A 292ALA A 295LEU A 324ALA A 323VAL A 230 | None | 0.95A | 5z12B-3ktcA:undetectable | 5z12B-3ktcA:13.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o0m | HIT FAMILY PROTEIN (Mycolicibacteriumsmegmatis) |
PF01230(HIT) | 6 | ILE A 67ALA A 70ALA A 71LEU A 76LEU A 136ALA A 135 | None | 1.16A | 5z12B-3o0mA:undetectable | 5z12B-3o0mA:21.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oks | 4-AMINOBUTYRATETRANSAMINASE (Mycolicibacteriumsmegmatis) |
PF00202(Aminotran_3) | 5 | ILE A 327ALA A 331ALA A 330LEU A 298ALA A 295 | None | 0.95A | 5z12B-3oksA:undetectable | 5z12B-3oksA:12.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q60 | ROP5B (Toxoplasmagondii) |
PF14531(Kinase-like) | 5 | ILE A 374ALA A 377ALA A 378LEU A 518LEU A 449 | None | 0.79A | 5z12B-3q60A:undetectable | 5z12B-3q60A:14.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rko | NADH-QUINONEOXIDOREDUCTASESUBUNIT N (Escherichiacoli) |
no annotation | 5 | ILE N 250ALA N 249LEU N 119ALA N 120LEU N 306 | None | 0.88A | 5z12B-3rkoN:undetectable | 5z12B-3rkoN:9.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rmj | 2-ISOPROPYLMALATESYNTHASE (Neisseriameningitidis) |
PF00682(HMGL-like) | 6 | ILE A 156ALA A 159TRP A 201PHE A 140ALA A 163LEU A 189 | None | 1.31A | 5z12B-3rmjA:undetectable | 5z12B-3rmjA:12.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3upn | PENICILLIN-BINDINGPROTEIN A (Mycobacteriumtuberculosis) |
PF00905(Transpeptidase) | 5 | ALA A 231ALA A 232LEU A 298ALA A 297LEU A 274 | None | 0.93A | 5z12B-3upnA:undetectable | 5z12B-3upnA:10.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vn3 | ANTIFREEZE PROTEIN (Typhulaishikariensis) |
PF11999(DUF3494) | 6 | ILE A 16ALA A 209ALA A 18ALA A 191VAL A 63LEU A 44 | NoneNoneNoneIYR A 91 ( 4.3A)NoneNone | 1.42A | 5z12B-3vn3A:undetectable | 5z12B-3vn3A:15.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wxw | ADIPONECTIN RECEPTORPROTEIN 2 (Homo sapiens) |
PF03006(HlyIII) | 5 | ILE A 322ALA A 325ALA A 326LEU A 283ALA A 279 | None | 0.69A | 5z12B-3wxwA:undetectable | 5z12B-3wxwA:14.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zil | AAR187CP (Eremotheciumgossypii) |
PF16997(Wap1) | 6 | ILE A 359ALA A 356TRP A 338LEU A 397ALA A 393LEU A 335 | None | 1.39A | 5z12B-3zilA:undetectable | 5z12B-3zilA:12.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zrg | PEXRD2 FAMILYSECRETED RXLREFFECTOR PEPTIDE,PUTATIVE (Phytophthorainfestans) |
no annotation | 6 | ILE A 86ALA A 89ALA A 90LEU A 99ALA A 95VAL A 73 | NoneNoneNone BR A1122 ( 4.5A)NoneNone | 1.49A | 5z12B-3zrgA:undetectable | 5z12B-3zrgA:22.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a7w | URIDYLATE KINASE (Helicobacterpylori) |
PF00696(AA_kinase) | 5 | ILE A 39ALA A 36LEU A 94ALA A 93VAL A 10 | None | 0.79A | 5z12B-4a7wA:undetectable | 5z12B-4a7wA:14.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b8b | GENERAL NEGATIVEREGULATOR OFTRANSCRIPTIONSUBUNIT 1 (Saccharomycescerevisiae) |
PF16417(CNOT1_TTP_bind)PF16418(CNOT1_HEAT)PF16419(CNOT1_HEAT_N) | 6 | ILE A 741ALA A 744ALA A 745LEU A 714ALA A 715VAL A 728 | None | 1.17A | 5z12B-4b8bA:undetectable | 5z12B-4b8bA:9.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ch7 | NIRD-LIKE PROTEIN (Hydrogenobacterthermophilus) |
no annotation | 5 | ILE A 175LEU A 205LEU A 197ALA A 194LEU A 217 | None | 0.88A | 5z12B-4ch7A:undetectable | 5z12B-4ch7A:12.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g1p | CYS-GLYMETALLODIPEPTIDASEDUG1 (Saccharomycescerevisiae) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 5 | ILE A 182ALA A 432LEU A 427LEU A 433VAL A 83 | None | 0.95A | 5z12B-4g1pA:undetectable | 5z12B-4g1pA:12.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g68 | ABC TRANSPORTER (Caldanaerobius) |
PF01547(SBP_bac_1) | 5 | ALA B 324ALA B 325LEU B 309LEU B 27LEU B 105 | None | 0.91A | 5z12B-4g68B:undetectable | 5z12B-4g68B:10.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g7f | ENOLASE (Trypanosomacruzi) |
PF00113(Enolase_C)PF03952(Enolase_N) | 5 | ILE A 116ALA A 119ALA A 120LEU A 83LEU A 135 | None | 0.98A | 5z12B-4g7fA:undetectable | 5z12B-4g7fA:13.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i59 | CYCLOHEXYLAMINEOXIDASE (Microbacteriumoxydans) |
PF01593(Amino_oxidase) | 5 | ALA A 471ALA A 470LEU A 50ALA A 49VAL A 273 | None | 0.91A | 5z12B-4i59A:undetectable | 5z12B-4i59A:11.18 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4j5x | RETINOIC ACIDRECEPTOR RXR-ALPHA,NUCLEAR RECEPTORCOACTIVATOR 1 (Homo sapiens) |
no annotation | 12 | ILE D 268ALA D 271ALA D 272TRP D 305LEU D 309PHE D 313ARG D 316LEU D 326ALA D 327VAL D 342CYH D 432LEU D 436 | None | 0.51A | 5z12B-4j5xD:34.2 | 5z12B-4j5xD:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jz7 | CARBAMATE KINASE (Giardiaintestinalis) |
PF00696(AA_kinase) | 5 | ILE A 39ALA A 36ALA A 35ALA A 96VAL A 7 | None | 0.82A | 5z12B-4jz7A:undetectable | 5z12B-4jz7A:15.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jz7 | CARBAMATE KINASE (Giardiaintestinalis) |
PF00696(AA_kinase) | 5 | ILE A 39ALA A 36ALA A 96VAL A 7LEU A 235 | None | 0.96A | 5z12B-4jz7A:undetectable | 5z12B-4jz7A:15.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k70 | UL37 (Suidalphaherpesvirus1) |
PF03970(Herpes_UL37_1) | 5 | ALA A 304ALA A 305ARG A 254VAL A 238LEU A 294 | None | 0.89A | 5z12B-4k70A:undetectable | 5z12B-4k70A:9.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nhb | TRAP DICARBOXYLATETRANSPORTER-DCTPSUBUNIT (Desulfovibriodesulfuricans) |
PF03480(DctP) | 5 | ILE A 258ALA A 261ALA A 262LEU A 240LEU A 54 | None | 0.79A | 5z12B-4nhbA:undetectable | 5z12B-4nhbA:17.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o5a | LACI FAMILYTRANSCRIPTIONREGULATOR (Bifidobacteriumanimalis) |
PF13377(Peripla_BP_3) | 5 | ALA A 309ALA A 308LEU A 96ALA A 95LEU A 133 | None | 0.95A | 5z12B-4o5aA:undetectable | 5z12B-4o5aA:11.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p47 | TRAP DICARBOXYLATETRANSPORTER, DCTPSUBUNIT (Ochrobactrumanthropi) |
PF03480(DctP) | 5 | ILE A 260ALA A 264ALA A 263LEU A 144ALA A 145 | None | 0.96A | 5z12B-4p47A:undetectable | 5z12B-4p47A:15.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pf6 | C4-DICARBOXYLATE-BINDING PROTEIN (Roseobacterdenitrificans) |
PF03480(DctP) | 5 | ILE A 242ALA A 267ALA A 268LEU A 46ALA A 45 | None | 0.96A | 5z12B-4pf6A:undetectable | 5z12B-4pf6A:14.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qfh | GLUCOSE-6-PHOSPHATEISOMERASE (Trypanosomacruzi) |
PF00342(PGI) | 6 | ILE A 356ALA A 542ALA A 354LEU A 350LEU A 92ALA A 539 | None | 1.39A | 5z12B-4qfhA:undetectable | 5z12B-4qfhA:8.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qiw | DNA-DIRECTED RNAPOLYMERASEDNA-DIRECTED RNAPOLYMERASE SUBUNITA'' (Thermococcuskodakarensis) |
PF00623(RNA_pol_Rpb1_2)PF04983(RNA_pol_Rpb1_3)PF04997(RNA_pol_Rpb1_1)PF04998(RNA_pol_Rpb1_5)PF05000(RNA_pol_Rpb1_4) | 5 | ILE C 72ALA C 69ALA C 68LEU C 307LEU A 845 | None | 0.95A | 5z12B-4qiwC:undetectable | 5z12B-4qiwC:11.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rrj | PROBABLETHREONINE--TRNALIGASE 2 (Aeropyrumpernix) |
PF08915(tRNA-Thr_ED) | 5 | ILE A 58ALA A 55ALA A 54LEU A 99ALA A 98 | None | 0.92A | 5z12B-4rrjA:undetectable | 5z12B-4rrjA:24.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4v1u | LYND (Lyngbyaaestuarii) |
PF02624(YcaO) | 6 | ILE A 264ALA A 261ALA A 260LEU A 134ALA A 133LEU A 286 | None | 1.26A | 5z12B-4v1uA:undetectable | 5z12B-4v1uA:7.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xa8 | D-ISOMER SPECIFIC2-HYDROXYACIDDEHYDROGENASENAD-BINDING (Xanthobacterautotrophicus) |
PF02826(2-Hacid_dh_C) | 5 | ILE A 296ALA A 293ALA A 292LEU A 25ALA A 24 | None | 0.92A | 5z12B-4xa8A:undetectable | 5z12B-4xa8A:13.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xbo | TRNA(CYTIDINE/URIDINE-2'-O-)-METHYLTRANSFERASE TRMJ (Escherichiacoli) |
PF00588(SpoU_methylase) | 6 | ALA A 53ALA A 22LEU A 49ALA A 50VAL A 40LEU A 9 | None | 1.07A | 5z12B-4xboA:undetectable | 5z12B-4xboA:14.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xbo | TRNA(CYTIDINE/URIDINE-2'-O-)-METHYLTRANSFERASE TRMJ (Escherichiacoli) |
PF00588(SpoU_methylase) | 6 | ILE A 57ALA A 53ALA A 22LEU A 49ALA A 50LEU A 9 | None | 1.40A | 5z12B-4xboA:undetectable | 5z12B-4xboA:14.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xgj | UNCHARACTERIZEDPROTEIN (Pectobacteriumatrosepticum) |
PF07005(DUF1537)PF17042(DUF1357_C) | 5 | ILE A 211ALA A 214ALA A 215LEU A 183ALA A 184 | None | 0.75A | 5z12B-4xgjA:undetectable | 5z12B-4xgjA:11.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yk2 | BARTONELLA EFFECTORPROTEIN (BEP)SUBSTRATE OF VIRBT4SS (Bartonellaclarridgeiae) |
no annotation | 5 | ILE A 160ALA A 156PHE A 103LEU A 140ALA A 141 | None | 0.87A | 5z12B-4yk2A:undetectable | 5z12B-4yk2A:20.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ynv | ACL4 (Chaetomiumthermophilum) |
PF13432(TPR_16) | 6 | ILE A 46ALA A 49ALA A 50LEU A 74LEU A 41ALA A 37 | None | 1.18A | 5z12B-4ynvA:undetectable | 5z12B-4ynvA:13.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gt5 | PECTATE LYASE (Paenibacillussp. 0602) |
no annotation | 5 | ILE A 117ALA A 116ALA A 115PHE A 132LEU A 39 | None | 0.97A | 5z12B-5gt5A:undetectable | 5z12B-5gt5A:12.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ip9 | DNA-DIRECTED RNAPOLYMERASE IISUBUNIT RPB1 (Saccharomycescerevisiae) |
PF00623(RNA_pol_Rpb1_2)PF04983(RNA_pol_Rpb1_3)PF04990(RNA_pol_Rpb1_7)PF04992(RNA_pol_Rpb1_6)PF04997(RNA_pol_Rpb1_1)PF04998(RNA_pol_Rpb1_5)PF05000(RNA_pol_Rpb1_4) | 5 | ILE A1072ALA A1069ALA A1068LEU A1370LEU A 841 | None | 0.94A | 5z12B-5ip9A:undetectable | 5z12B-5ip9A:4.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mzy | GLUTACONATECOA-TRANSFERASEFAMILY, SUBUNIT A (Myxococcusxanthus) |
PF01144(CoA_trans) | 5 | ALA A 189ALA A 190PHE A 157LEU A 113ALA A 116 | None | 0.92A | 5z12B-5mzyA:undetectable | 5z12B-5mzyA:17.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n0g | PRECORRIN-8XMETHYLMUTASE (Rhodobactercapsulatus) |
no annotation | 6 | ILE A 73ALA A 71ALA A 130LEU A 67ALA A 66VAL A 80 | None | 1.18A | 5z12B-5n0gA:undetectable | 5z12B-5n0gA:21.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nzg | UDP-GLUCOSEPYROPHOSPHORYLASE (Leishmaniamajor) |
no annotation | 6 | ILE A 360ALA A 361ALA A 359LEU A 330VAL A 246LEU A 310 | None | 1.47A | 5z12B-5nzgA:undetectable | 5z12B-5nzgA:17.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ohs | - (-) |
no annotation | 5 | ILE A 257ALA A 260PHE A 541LEU A 538ALA A 539 | None | 0.83A | 5z12B-5ohsA:undetectable | 5z12B-5ohsA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5thh | TYROSINE--TRNALIGASE, CYTOPLASMIC (Homo sapiens) |
PF00579(tRNA-synt_1b) | 5 | ALA A 65LEU A 13ALA A 60VAL A 208LEU A 31 | None | 0.98A | 5z12B-5thhA:undetectable | 5z12B-5thhA:13.65 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5toa | ESTROGEN RECEPTORBETA (Homo sapiens) |
PF00104(Hormone_recep) | 5 | ALA A 302TRP A 335LEU A 339ARG A 346LEU A 476 | EST A 601 ( 3.9A)NoneEST A 601 (-3.9A)EST A 601 (-4.1A)EST A 601 (-3.5A) | 0.92A | 5z12B-5toaA:23.8 | 5z12B-5toaA:36.90 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5uan | RETINOIC ACIDRECEPTOR RXR-ALPHA (Homo sapiens) |
no annotation | 12 | ILE A 268ALA A 271ALA A 272TRP A 305LEU A 309PHE A 313ARG A 316LEU A 326ALA A 327VAL A 342CYH A 432LEU A 436 | 9CR A 503 (-4.0A)9CR A 503 (-3.5A)9CR A 503 (-3.5A)None9CR A 503 (-3.7A)9CR A 503 (-4.7A)9CR A 503 (-3.0A)9CR A 503 (-4.3A)9CR A 503 (-3.4A)None9CR A 503 (-3.3A)9CR A 503 ( 4.8A) | 0.53A | 5z12B-5uanA:34.4 | 5z12B-5uanA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uvm | HISTIDINE TRIAD(HIT) PROTEIN (Ruminiclostridiumthermocellum) |
PF11969(DcpS_C) | 5 | ILE A 64ALA A 67ALA A 68LEU A 103ALA A 27 | None | 0.91A | 5z12B-5uvmA:undetectable | 5z12B-5uvmA:18.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uvm | HISTIDINE TRIAD(HIT) PROTEIN (Ruminiclostridiumthermocellum) |
PF11969(DcpS_C) | 5 | ILE A 64ALA A 67ALA A 68LEU A 103VAL A 50 | None | 0.87A | 5z12B-5uvmA:undetectable | 5z12B-5uvmA:18.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ve8 | KAP123 (Kluyveromyceslactis) |
no annotation | 5 | ILE A 302ALA A 305ALA A 306LEU A 262ALA A 265 | None | 0.95A | 5z12B-5ve8A:undetectable | 5z12B-5ve8A:6.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xnz | CRED (Streptomycescremeus) |
no annotation | 5 | ILE A 54ALA A 57ALA A 58LEU A 30ALA A 89 | None | 0.97A | 5z12B-5xnzA:undetectable | 5z12B-5xnzA:20.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xyi | RIBOSOMAL PROTEINS19E, PUTATIVE (Trichomonasvaginalis) |
PF01090(Ribosomal_S19e) | 5 | ILE T 68ALA T 65ALA T 64LEU T 25ALA T 26 | None | 0.98A | 5z12B-5xyiT:undetectable | 5z12B-5xyiT:22.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xym | 50S RIBOSOMALPROTEIN L22 (Mycolicibacteriumsmegmatis) |
PF00237(Ribosomal_L22) | 5 | ALA S 61ALA S 62LEU S 76ALA S 10LEU S 40 | None | 0.93A | 5z12B-5xymS:undetectable | 5z12B-5xymS:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c66 | CRISPR-ASSOCIATEDPROTEIN, CSE1 FAMILY (Thermobifidafusca) |
no annotation | 5 | ILE A 71LEU A 273ALA A 268VAL A 182LEU A 44 | None | 0.96A | 5z12B-6c66A:undetectable | 5z12B-6c66A:25.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6d95 | - (-) |
no annotation | 6 | ILE A 129ALA A 132ALA A 133LEU A 138LEU A 267ALA A 266 | None | 0.90A | 5z12B-6d95A:undetectable | 5z12B-6d95A:undetectable |