SIMILAR PATTERNS OF AMINO ACIDS FOR 5Z12_B_9CRB501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)

(Hepacivirus C) 		PF00998
(RdRP_3) 		5 ALA A 249
ALA A 174
LEU A 245
ALA A 246
LEU A 285
 None
 0.94A 5z12B-1csjA:
undetectable		 5z12B-1csjA:
10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e19 CARBAMATE KINASE

(Pyrococcus
furiosus) 		PF00696
(AA_kinase) 		6 ILE A  37
ALA A  34
LEU A  97
ALA A  96
VAL A   5
LEU A 234
 None
 0.91A 5z12B-1e19A:
undetectable		 5z12B-1e19A:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		5 ILE A 238
ALA A 255
ALA A 256
LEU A 100
ALA A  97
 None
 0.91A 5z12B-1fc4A:
undetectable		 5z12B-1fc4A:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gxn PECTATE LYASE

(Cellvibrio
japonicus) 		PF09492
(Pec_lyase) 		5 ILE A 552
ALA A 555
LEU A 540
LEU A 496
LEU A 331
 None
 0.91A 5z12B-1gxnA:
undetectable		 5z12B-1gxnA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hg4 ULTRASPIRACLE

(Drosophila
melanogaster) 		PF00104
(Hormone_recep) 		5 TRP A 318
LEU A 322
VAL A 382
CYH A 472
LEU A 476
 None
LPP  A   1 ( 4.8A)
LPP  A   1 (-4.8A)
LPP  A   1 ( 4.2A)
LPP  A   1 (-4.2A)
 0.59A 5z12B-1hg4A:
24.7		 5z12B-1hg4A:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hg4 ULTRASPIRACLE

(Drosophila
melanogaster) 		PF00104
(Hormone_recep) 		5 TRP A 318
LEU A 366
VAL A 382
CYH A 472
LEU A 476
 None
LPP  A   1 ( 4.4A)
LPP  A   1 (-4.8A)
LPP  A   1 ( 4.2A)
LPP  A   1 (-4.2A)
 0.67A 5z12B-1hg4A:
24.7		 5z12B-1hg4A:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iqr PHOTOLYASE

(Thermus
thermophilus) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		6 ALA A 227
ALA A 226
LEU A 225
LEU A 124
ALA A 146
LEU A 212
 None
 1.18A 5z12B-1iqrA:
undetectable		 5z12B-1iqrA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0h NEOPULLULANASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		5 ILE A 428
ALA A 388
LEU A 441
LEU A 384
LEU A 486
 None
 0.87A 5z12B-1j0hA:
undetectable		 5z12B-1j0hA:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lv7 FTSH

(Escherichia
coli) 		PF00004
(AAA) 		6 ILE A 253
ALA A 298
LEU A 306
ALA A 299
VAL A 236
LEU A 282
 None
 1.40A 5z12B-1lv7A:
undetectable		 5z12B-1lv7A:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n60 CARBON MONOXIDE
DEHYDROGENASE SMALL
CHAIN

(Oligotropha
carboxidovorans) 		PF00111
(Fer2)
PF01799
(Fer2_2) 		5 ILE A 149
ALA A 152
ALA A 153
LEU A  90
ALA A  89
 None
 0.92A 5z12B-1n60A:
undetectable		 5z12B-1n60A:
16.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 ALA A 350
TRP A 383
LEU A 387
ARG A 394
VAL A 418
LEU A 525
 EST  A   1 ( 3.7A)
None
EST  A   1 (-4.0A)
EST  A   1 (-3.7A)
None
EST  A   1 (-3.6A)
 0.92A 5z12B-1pcgA:
25.8		 5z12B-1pcgA:
35.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r20 ULTRASPIRACLE
PROTEIN

(Heliothis
virescens) 		PF00104
(Hormone_recep) 		5 TRP A 286
ARG A 297
LEU A 325
VAL A 341
LEU A 435
 None
None
None
EPH  A4000 (-4.9A)
EPH  A4000 ( 4.6A)
 0.66A 5z12B-1r20A:
24.3		 5z12B-1r20A:
40.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r20 ULTRASPIRACLE
PROTEIN

(Heliothis
virescens) 		PF00104
(Hormone_recep) 		5 TRP A 286
LEU A 290
ARG A 297
LEU A 325
LEU A 435
 None
EPH  A4000 ( 4.8A)
None
None
EPH  A4000 ( 4.6A)
 0.98A 5z12B-1r20A:
24.3		 5z12B-1r20A:
40.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdj BIOSYNTHETIC
THREONINE DEAMINASE

(Escherichia
coli) 		PF00291
(PALP)
PF00585
(Thr_dehydrat_C) 		6 ILE A 270
ALA A 294
ALA A 273
LEU A 277
LEU A 291
ALA A 292
 None
 1.42A 5z12B-1tdjA:
undetectable		 5z12B-1tdjA:
10.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uhl RETINOIC ACID
RECEPTOR RXR-BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		12 ILE A 339
ALA A 342
ALA A 343
TRP A 376
LEU A 380
PHE A 384
ARG A 387
LEU A 397
ALA A 398
VAL A 413
CYH A 503
LEU A 507
 MEI  A1001 (-3.8A)
MEI  A1001 (-3.1A)
MEI  A1001 (-3.3A)
None
MEI  A1001 (-3.8A)
MEI  A1001 (-4.5A)
MEI  A1001 (-3.6A)
MEI  A1001 ( 4.4A)
MEI  A1001 (-3.4A)
MEI  A1001 (-4.1A)
MEI  A1001 (-4.0A)
MEI  A1001 (-4.6A)
 0.55A 5z12B-1uhlA:
35.6		 5z12B-1uhlA:
80.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vdl UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 25

(Mus musculus) 		PF14555
(UBA_4) 		5 ILE A  42
ALA A  46
LEU A  28
LEU A  61
ALA A  57
 None
 0.95A 5z12B-1vdlA:
undetectable		 5z12B-1vdlA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wra TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/CHOLINE
BINDING PROTEIN E
(CBPE)

(Streptococcus
pneumoniae) 		PF00753
(Lactamase_B) 		5 ILE A  47
ALA A  45
LEU A  87
VAL A 100
LEU A 122
 None
 0.94A 5z12B-1wraA:
undetectable		 5z12B-1wraA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xa0 PUTATIVE NADPH
DEPENDENT
OXIDOREDUCTASES

(Geobacillus
stearothermophilus) 		PF00107
(ADH_zinc_N) 		5 ALA A 134
ALA A 135
LEU A 291
LEU A 165
ALA A 166
 None
 0.88A 5z12B-1xa0A:
undetectable		 5z12B-1xa0A:
13.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xiu RXR-LIKE PROTEIN

(Biomphalaria
glabrata) 		PF00104
(Hormone_recep) 		12 ILE A 242
ALA A 245
ALA A 246
TRP A 279
LEU A 283
PHE A 287
ARG A 290
LEU A 300
ALA A 301
VAL A 316
CYH A 406
LEU A 410
 9CR  A 201 ( 4.4A)
9CR  A 201 (-3.6A)
9CR  A 201 (-3.6A)
None
9CR  A 201 ( 4.1A)
9CR  A 201 (-4.7A)
9CR  A 201 (-2.8A)
9CR  A 201 (-4.4A)
9CR  A 201 (-3.4A)
9CR  A 201 (-4.2A)
9CR  A 201 (-3.6A)
9CR  A 201 ( 4.8A)
 0.36A 5z12B-1xiuA:
32.8		 5z12B-1xiuA:
73.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xls RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		12 ILE A 268
ALA A 271
ALA A 272
TRP A 305
LEU A 309
PHE A 313
ARG A 316
LEU A 326
ALA A 327
VAL A 342
CYH A 432
LEU A 436
 9CR  A 801 (-3.9A)
9CR  A 801 (-3.6A)
9CR  A 801 (-3.5A)
None
9CR  A 801 (-4.2A)
9CR  A 801 (-4.3A)
9CR  A 801 (-2.6A)
9CR  A 801 (-4.1A)
9CR  A 801 (-3.3A)
9CR  A 801 ( 4.3A)
9CR  A 801 ( 3.7A)
9CR  A 801 (-4.7A)
 0.33A 5z12B-1xlsA:
35.4		 5z12B-1xlsA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1z5x ULTRASPIRACLE
PROTEIN (USP) A
HOMOLOGUE OF RXR

(Bemisia tabaci) 		PF00104
(Hormone_recep) 		5 ILE U 303
ALA U 306
ALA U 307
LEU U 365
ALA U 362
 None
 0.91A 5z12B-1z5xU:
22.0		 5z12B-1z5xU:
48.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bib TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/ CHOLINE
BINDING PROTEIN

(Streptococcus
pneumoniae) 		PF00753
(Lactamase_B)
PF01473
(CW_binding_1) 		5 ILE A  22
ALA A  20
LEU A  62
VAL A  75
LEU A  97
 None
 0.95A 5z12B-2bibA:
undetectable		 5z12B-2bibA:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpn GLYCEROL KINASE

(Thermus
thermophilus) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		6 ALA A  57
ALA A  58
LEU A   5
ALA A  29
VAL A 163
LEU A 171
 None
 1.04A 5z12B-2dpnA:
undetectable		 5z12B-2dpnA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gjm LACTOPEROXIDASE

(Bubalus bubalis) 		PF03098
(An_peroxidase) 		6 ILE A 478
LEU A 467
ARG A 426
LEU A 422
ALA A  61
LEU A 460
 None
 1.27A 5z12B-2gjmA:
undetectable		 5z12B-2gjmA:
10.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gl8 RETINOIC ACID
RECEPTOR RXR-GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 TRP A  84
LEU A  88
PHE A  92
ARG A  95
LEU A 105
ALA A 106
VAL A 121
CYH A 211
 None
 0.72A 5z12B-2gl8A:
27.7		 5z12B-2gl8A:
83.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hxo PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		5 ILE A  20
ALA A  23
ALA A  24
LEU A  36
LEU A  45
 None
 0.98A 5z12B-2hxoA:
undetectable		 5z12B-2hxoA:
20.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2nxx ULTRASPIRACLE (USP,
NR2B4)

(Tribolium
castaneum) 		PF00104
(Hormone_recep) 		6 LEU A 255
PHE A 259
ARG A 262
LEU A 272
ALA A 273
CYH A 378
 None
 0.96A 5z12B-2nxxA:
25.4		 5z12B-2nxxA:
52.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 ALA A 350
TRP A 383
LEU A 387
ARG A 394
VAL A 418
LEU A 525
 EST  A 596 ( 3.9A)
None
EST  A 596 ( 4.2A)
EST  A 596 (-4.0A)
CME  A 417 ( 3.2A)
EST  A 596 (-3.6A)
 0.94A 5z12B-2ocfA:
25.9		 5z12B-2ocfA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ptz ENOLASE

(Trypanosoma
brucei) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 ILE A 116
ALA A 119
ALA A 120
LEU A  83
LEU A 135
 None
 0.97A 5z12B-2ptzA:
undetectable		 5z12B-2ptzA:
15.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q60 RETINOID X RECEPTOR

(Polyandrocarpa
misakiensis) 		PF00104
(Hormone_recep) 		7 TRP A 180
LEU A 184
PHE A 188
ARG A 191
ALA A 202
VAL A 217
CYH A 307
 None
 0.55A 5z12B-2q60A:
26.8		 5z12B-2q60A:
51.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qpm CYTOKININ
DEHYDROGENASE 1

(Zea mays) 		PF01565
(FAD_binding_4)
PF09265
(Cytokin-bind) 		5 ILE A 315
ALA A 313
LEU A 301
ALA A 302
VAL A 360
 None
 0.97A 5z12B-2qpmA:
undetectable		 5z12B-2qpmA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vml PHYCOCYANIN ALPHA
CHAIN
PHYCOCYANIN BETA
CHAIN

(Gloeobacter
violaceus) 		PF00502
(Phycobilisome) 		5 ALA A  40
ALA A  41
ALA A 150
VAL B  31
LEU B  24
 None
 0.92A 5z12B-2vmlA:
undetectable		 5z12B-2vmlA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1z ROP2

(Toxoplasma
gondii) 		PF14531
(Kinase-like) 		5 ILE A 394
ALA A 397
ALA A 398
LEU A 532
LEU A 476
 None
 0.82A 5z12B-2w1zA:
undetectable		 5z12B-2w1zA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xax RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 1
SUBUNIT ALPHA

(Escherichia
coli) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		5 ILE A  62
ALA A  66
ALA A  65
LEU A  84
ALA A  81
 None
 0.96A 5z12B-2xaxA:
undetectable		 5z12B-2xaxA:
7.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xgo XCOGT

(Xanthomonas
campestris) 		PF13432
(TPR_16)
PF13844
(Glyco_transf_41) 		5 ALA A 549
PHE A 228
LEU A 231
ALA A 230
LEU A 328
 None
 0.98A 5z12B-2xgoA:
undetectable		 5z12B-2xgoA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7c GENE 0.3 PROTEIN

(Escherichia
virus T7) 		PF08684
(ocr) 		5 ILE D  33
ALA D  36
ALA D  37
LEU D  85
LEU D  14
 None
 0.82A 5z12B-2y7cD:
undetectable		 5z12B-2y7cD:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afg SUBTILISIN-LIKE
SERINE PROTEASE

(Thermococcus
kodakarensis) 		PF00082
(Peptidase_S8)
PF04151
(PPC) 		5 ILE A 368
ALA A 415
ALA A 416
LEU A 388
ALA A 387
 None
 0.90A 5z12B-3afgA:
undetectable		 5z12B-3afgA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3am6 RHODOPSIN-2

(Acetabularia
acetabulum) 		PF01036
(Bac_rhodopsin) 		5 ILE A  44
ALA A  47
VAL A  95
CYH A 218
LEU A 219
 None
None
None
None
CLR  A 401 ( 4.6A)
 0.97A 5z12B-3am6A:
undetectable		 5z12B-3am6A:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3djc TYPE III
PANTOTHENATE KINASE

(Legionella
pneumophila) 		PF03309
(Pan_kinase) 		5 ALA A 115
ALA A 116
LEU A 220
VAL A 105
CYH A 137
 None
 0.90A 5z12B-3djcA:
undetectable		 5z12B-3djcA:
16.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		12 ILE A 268
ALA A 271
ALA A 272
TRP A 305
LEU A 309
PHE A 313
ARG A 316
LEU A 326
ALA A 327
VAL A 342
CYH A 432
LEU A 436
 9CR  A7223 (-3.9A)
9CR  A7223 (-3.5A)
9CR  A7223 (-4.2A)
None
9CR  A7223 ( 4.4A)
9CR  A7223 (-4.5A)
9CR  A7223 (-3.7A)
9CR  A7223 (-3.8A)
9CR  A7223 ( 4.7A)
9CR  A7223 ( 4.5A)
9CR  A7223 (-3.8A)
9CR  A7223 ( 4.7A)
 0.60A 5z12B-3dzuA:
33.8		 5z12B-3dzuA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3eyb NUCLEAR HORMONE
RECEPTOR RXR

(Branchiostoma
floridae) 		PF00104
(Hormone_recep) 		5 LEU A 338
PHE A 342
ALA A 356
VAL A 371
CYH A 461
 None
 0.85A 5z12B-3eybA:
28.4		 5z12B-3eybA:
75.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB11
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3

(Schizosaccharomyces
pombe) 		PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L)
PF13656
(RNA_pol_L_2) 		5 ILE K  86
ALA K  89
ALA K  90
LEU C 256
LEU K  49
 None
 0.95A 5z12B-3h0gK:
undetectable		 5z12B-3h0gK:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hve GIGAXONIN

(Homo sapiens) 		PF00651
(BTB)
PF07707
(BACK) 		5 ILE A  47
ALA A  50
ALA A  51
LEU B  20
ALA B  19
 None
 0.68A 5z12B-3hveA:
undetectable		 5z12B-3hveA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hve GIGAXONIN

(Homo sapiens) 		PF00651
(BTB)
PF07707
(BACK) 		5 ILE A  47
ALA A  50
LEU B  20
ALA B  19
LEU A  87
 None
 0.75A 5z12B-3hveA:
undetectable		 5z12B-3hveA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hve GIGAXONIN

(Homo sapiens) 		PF00651
(BTB)
PF07707
(BACK) 		5 ILE B  47
ALA B  50
ALA B  51
LEU A  20
ALA A  19
 None
 0.71A 5z12B-3hveB:
undetectable		 5z12B-3hveB:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hve GIGAXONIN

(Homo sapiens) 		PF00651
(BTB)
PF07707
(BACK) 		5 ILE B  47
ALA B  50
LEU A  20
ALA A  19
LEU B  87
 None
 0.93A 5z12B-3hveB:
undetectable		 5z12B-3hveB:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ic5 PUTATIVE
SACCHAROPINE
DEHYDROGENASE

(Ruegeria
pomeroyi) 		PF03435
(Sacchrp_dh_NADP) 		5 ILE A  82
ALA A  85
ALA A  86
LEU A  60
ALA A  61
 None
 0.84A 5z12B-3ic5A:
undetectable		 5z12B-3ic5A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ktc XYLOSE ISOMERASE

(Pectobacterium
atrosepticum) 		PF01261
(AP_endonuc_2) 		5 ILE A 292
ALA A 295
LEU A 324
ALA A 323
VAL A 230
 None
 0.95A 5z12B-3ktcA:
undetectable		 5z12B-3ktcA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o0m HIT FAMILY PROTEIN

(Mycolicibacterium
smegmatis) 		PF01230
(HIT) 		6 ILE A  67
ALA A  70
ALA A  71
LEU A  76
LEU A 136
ALA A 135
 None
 1.16A 5z12B-3o0mA:
undetectable		 5z12B-3o0mA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oks 4-AMINOBUTYRATE
TRANSAMINASE

(Mycolicibacterium
smegmatis) 		PF00202
(Aminotran_3) 		5 ILE A 327
ALA A 331
ALA A 330
LEU A 298
ALA A 295
 None
 0.95A 5z12B-3oksA:
undetectable		 5z12B-3oksA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q60 ROP5B

(Toxoplasma
gondii) 		PF14531
(Kinase-like) 		5 ILE A 374
ALA A 377
ALA A 378
LEU A 518
LEU A 449
 None
 0.79A 5z12B-3q60A:
undetectable		 5z12B-3q60A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N

(Escherichia
coli) 		no annotation 5 ILE N 250
ALA N 249
LEU N 119
ALA N 120
LEU N 306
 None
 0.88A 5z12B-3rkoN:
undetectable		 5z12B-3rkoN:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rmj 2-ISOPROPYLMALATE
SYNTHASE

(Neisseria
meningitidis) 		PF00682
(HMGL-like) 		6 ILE A 156
ALA A 159
TRP A 201
PHE A 140
ALA A 163
LEU A 189
 None
 1.31A 5z12B-3rmjA:
undetectable		 5z12B-3rmjA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3upn PENICILLIN-BINDING
PROTEIN A

(Mycobacterium
tuberculosis) 		PF00905
(Transpeptidase) 		5 ALA A 231
ALA A 232
LEU A 298
ALA A 297
LEU A 274
 None
 0.93A 5z12B-3upnA:
undetectable		 5z12B-3upnA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vn3 ANTIFREEZE PROTEIN

(Typhula
ishikariensis) 		PF11999
(DUF3494) 		6 ILE A  16
ALA A 209
ALA A  18
ALA A 191
VAL A  63
LEU A  44
 None
None
None
IYR  A  91 ( 4.3A)
None
None
 1.42A 5z12B-3vn3A:
undetectable		 5z12B-3vn3A:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxw ADIPONECTIN RECEPTOR
PROTEIN 2

(Homo sapiens) 		PF03006
(HlyIII) 		5 ILE A 322
ALA A 325
ALA A 326
LEU A 283
ALA A 279
 None
 0.69A 5z12B-3wxwA:
undetectable		 5z12B-3wxwA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zil AAR187CP

(Eremothecium
gossypii) 		PF16997
(Wap1) 		6 ILE A 359
ALA A 356
TRP A 338
LEU A 397
ALA A 393
LEU A 335
 None
 1.39A 5z12B-3zilA:
undetectable		 5z12B-3zilA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zrg PEXRD2 FAMILY
SECRETED RXLR
EFFECTOR PEPTIDE,
PUTATIVE

(Phytophthora
infestans) 		no annotation 6 ILE A  86
ALA A  89
ALA A  90
LEU A  99
ALA A  95
VAL A  73
 None
None
None
BR  A1122 ( 4.5A)
None
None
 1.49A 5z12B-3zrgA:
undetectable		 5z12B-3zrgA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a7w URIDYLATE KINASE

(Helicobacter
pylori) 		PF00696
(AA_kinase) 		5 ILE A  39
ALA A  36
LEU A  94
ALA A  93
VAL A  10
 None
 0.79A 5z12B-4a7wA:
undetectable		 5z12B-4a7wA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF16417
(CNOT1_TTP_bind)
PF16418
(CNOT1_HEAT)
PF16419
(CNOT1_HEAT_N) 		6 ILE A 741
ALA A 744
ALA A 745
LEU A 714
ALA A 715
VAL A 728
 None
 1.17A 5z12B-4b8bA:
undetectable		 5z12B-4b8bA:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ch7 NIRD-LIKE PROTEIN

(Hydrogenobacter
thermophilus) 		no annotation 5 ILE A 175
LEU A 205
LEU A 197
ALA A 194
LEU A 217
 None
 0.88A 5z12B-4ch7A:
undetectable		 5z12B-4ch7A:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1

(Saccharomyces
cerevisiae) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 ILE A 182
ALA A 432
LEU A 427
LEU A 433
VAL A  83
 None
 0.95A 5z12B-4g1pA:
undetectable		 5z12B-4g1pA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g68 ABC TRANSPORTER

(Caldanaerobius) 		PF01547
(SBP_bac_1) 		5 ALA B 324
ALA B 325
LEU B 309
LEU B  27
LEU B 105
 None
 0.91A 5z12B-4g68B:
undetectable		 5z12B-4g68B:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g7f ENOLASE

(Trypanosoma
cruzi) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 ILE A 116
ALA A 119
ALA A 120
LEU A  83
LEU A 135
 None
 0.98A 5z12B-4g7fA:
undetectable		 5z12B-4g7fA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i59 CYCLOHEXYLAMINE
OXIDASE

(Microbacterium
oxydans) 		PF01593
(Amino_oxidase) 		5 ALA A 471
ALA A 470
LEU A  50
ALA A  49
VAL A 273
 None
 0.91A 5z12B-4i59A:
undetectable		 5z12B-4i59A:
11.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4j5x RETINOIC ACID
RECEPTOR RXR-ALPHA,
NUCLEAR RECEPTOR
COACTIVATOR 1

(Homo sapiens) 		no annotation 12 ILE D 268
ALA D 271
ALA D 272
TRP D 305
LEU D 309
PHE D 313
ARG D 316
LEU D 326
ALA D 327
VAL D 342
CYH D 432
LEU D 436
 None
 0.51A 5z12B-4j5xD:
34.2		 5z12B-4j5xD:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jz7 CARBAMATE KINASE

(Giardia
intestinalis) 		PF00696
(AA_kinase) 		5 ILE A  39
ALA A  36
ALA A  35
ALA A  96
VAL A   7
 None
 0.82A 5z12B-4jz7A:
undetectable		 5z12B-4jz7A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jz7 CARBAMATE KINASE

(Giardia
intestinalis) 		PF00696
(AA_kinase) 		5 ILE A  39
ALA A  36
ALA A  96
VAL A   7
LEU A 235
 None
 0.96A 5z12B-4jz7A:
undetectable		 5z12B-4jz7A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k70 UL37

(Suid
alphaherpesvirus
1) 		PF03970
(Herpes_UL37_1) 		5 ALA A 304
ALA A 305
ARG A 254
VAL A 238
LEU A 294
 None
 0.89A 5z12B-4k70A:
undetectable		 5z12B-4k70A:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nhb TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT

(Desulfovibrio
desulfuricans) 		PF03480
(DctP) 		5 ILE A 258
ALA A 261
ALA A 262
LEU A 240
LEU A  54
 None
 0.79A 5z12B-4nhbA:
undetectable		 5z12B-4nhbA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5a LACI FAMILY
TRANSCRIPTION
REGULATOR

(Bifidobacterium
animalis) 		PF13377
(Peripla_BP_3) 		5 ALA A 309
ALA A 308
LEU A  96
ALA A  95
LEU A 133
 None
 0.95A 5z12B-4o5aA:
undetectable		 5z12B-4o5aA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p47 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Ochrobactrum
anthropi) 		PF03480
(DctP) 		5 ILE A 260
ALA A 264
ALA A 263
LEU A 144
ALA A 145
 None
 0.96A 5z12B-4p47A:
undetectable		 5z12B-4p47A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pf6 C4-DICARBOXYLATE-BIN
DING PROTEIN

(Roseobacter
denitrificans) 		PF03480
(DctP) 		5 ILE A 242
ALA A 267
ALA A 268
LEU A  46
ALA A  45
 None
 0.96A 5z12B-4pf6A:
undetectable		 5z12B-4pf6A:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfh GLUCOSE-6-PHOSPHATE
ISOMERASE

(Trypanosoma
cruzi) 		PF00342
(PGI) 		6 ILE A 356
ALA A 542
ALA A 354
LEU A 350
LEU A  92
ALA A 539
 None
 1.39A 5z12B-4qfhA:
undetectable		 5z12B-4qfhA:
8.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''

(Thermococcus
kodakarensis) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		5 ILE C  72
ALA C  69
ALA C  68
LEU C 307
LEU A 845
 None
 0.95A 5z12B-4qiwC:
undetectable		 5z12B-4qiwC:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rrj PROBABLE
THREONINE--TRNA
LIGASE 2

(Aeropyrum
pernix) 		PF08915
(tRNA-Thr_ED) 		5 ILE A  58
ALA A  55
ALA A  54
LEU A  99
ALA A  98
 None
 0.92A 5z12B-4rrjA:
undetectable		 5z12B-4rrjA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1u LYND

(Lyngbya
aestuarii) 		PF02624
(YcaO) 		6 ILE A 264
ALA A 261
ALA A 260
LEU A 134
ALA A 133
LEU A 286
 None
 1.26A 5z12B-4v1uA:
undetectable		 5z12B-4v1uA:
7.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xa8 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE
NAD-BINDING

(Xanthobacter
autotrophicus) 		PF02826
(2-Hacid_dh_C) 		5 ILE A 296
ALA A 293
ALA A 292
LEU A  25
ALA A  24
 None
 0.92A 5z12B-4xa8A:
undetectable		 5z12B-4xa8A:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ

(Escherichia
coli) 		PF00588
(SpoU_methylase) 		6 ALA A  53
ALA A  22
LEU A  49
ALA A  50
VAL A  40
LEU A   9
 None
 1.07A 5z12B-4xboA:
undetectable		 5z12B-4xboA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ

(Escherichia
coli) 		PF00588
(SpoU_methylase) 		6 ILE A  57
ALA A  53
ALA A  22
LEU A  49
ALA A  50
LEU A   9
 None
 1.40A 5z12B-4xboA:
undetectable		 5z12B-4xboA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgj UNCHARACTERIZED
PROTEIN

(Pectobacterium
atrosepticum) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		5 ILE A 211
ALA A 214
ALA A 215
LEU A 183
ALA A 184
 None
 0.75A 5z12B-4xgjA:
undetectable		 5z12B-4xgjA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yk2 BARTONELLA EFFECTOR
PROTEIN (BEP)
SUBSTRATE OF VIRB
T4SS

(Bartonella
clarridgeiae) 		no annotation 5 ILE A 160
ALA A 156
PHE A 103
LEU A 140
ALA A 141
 None
 0.87A 5z12B-4yk2A:
undetectable		 5z12B-4yk2A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynv ACL4

(Chaetomium
thermophilum) 		PF13432
(TPR_16) 		6 ILE A  46
ALA A  49
ALA A  50
LEU A  74
LEU A  41
ALA A  37
 None
 1.18A 5z12B-4ynvA:
undetectable		 5z12B-4ynvA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gt5 PECTATE LYASE

(Paenibacillus
sp. 0602) 		no annotation 5 ILE A 117
ALA A 116
ALA A 115
PHE A 132
LEU A  39
 None
 0.97A 5z12B-5gt5A:
undetectable		 5z12B-5gt5A:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1

(Saccharomyces
cerevisiae) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		5 ILE A1072
ALA A1069
ALA A1068
LEU A1370
LEU A 841
 None
 0.94A 5z12B-5ip9A:
undetectable		 5z12B-5ip9A:
4.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzy GLUTACONATE
COA-TRANSFERASE
FAMILY, SUBUNIT A

(Myxococcus
xanthus) 		PF01144
(CoA_trans) 		5 ALA A 189
ALA A 190
PHE A 157
LEU A 113
ALA A 116
 None
 0.92A 5z12B-5mzyA:
undetectable		 5z12B-5mzyA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n0g PRECORRIN-8X
METHYLMUTASE

(Rhodobacter
capsulatus) 		no annotation 6 ILE A  73
ALA A  71
ALA A 130
LEU A  67
ALA A  66
VAL A  80
 None
 1.18A 5z12B-5n0gA:
undetectable		 5z12B-5n0gA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE

(Leishmania
major) 		no annotation 6 ILE A 360
ALA A 361
ALA A 359
LEU A 330
VAL A 246
LEU A 310
 None
 1.47A 5z12B-5nzgA:
undetectable		 5z12B-5nzgA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohs -

(-) 		no annotation 5 ILE A 257
ALA A 260
PHE A 541
LEU A 538
ALA A 539
 None
 0.83A 5z12B-5ohsA:
undetectable		 5z12B-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thh TYROSINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF00579
(tRNA-synt_1b) 		5 ALA A  65
LEU A  13
ALA A  60
VAL A 208
LEU A  31
 None
 0.98A 5z12B-5thhA:
undetectable		 5z12B-5thhA:
13.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ALA A 302
TRP A 335
LEU A 339
ARG A 346
LEU A 476
 EST  A 601 ( 3.9A)
None
EST  A 601 (-3.9A)
EST  A 601 (-4.1A)
EST  A 601 (-3.5A)
 0.92A 5z12B-5toaA:
23.8		 5z12B-5toaA:
36.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uan RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		no annotation 12 ILE A 268
ALA A 271
ALA A 272
TRP A 305
LEU A 309
PHE A 313
ARG A 316
LEU A 326
ALA A 327
VAL A 342
CYH A 432
LEU A 436
 9CR  A 503 (-4.0A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
None
9CR  A 503 (-3.7A)
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-4.3A)
9CR  A 503 (-3.4A)
None
9CR  A 503 (-3.3A)
9CR  A 503 ( 4.8A)
 0.53A 5z12B-5uanA:
34.4		 5z12B-5uanA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uvm HISTIDINE TRIAD
(HIT) PROTEIN

(Ruminiclostridium
thermocellum) 		PF11969
(DcpS_C) 		5 ILE A  64
ALA A  67
ALA A  68
LEU A 103
ALA A  27
 None
 0.91A 5z12B-5uvmA:
undetectable		 5z12B-5uvmA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uvm HISTIDINE TRIAD
(HIT) PROTEIN

(Ruminiclostridium
thermocellum) 		PF11969
(DcpS_C) 		5 ILE A  64
ALA A  67
ALA A  68
LEU A 103
VAL A  50
 None
 0.87A 5z12B-5uvmA:
undetectable		 5z12B-5uvmA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ve8 KAP123

(Kluyveromyces
lactis) 		no annotation 5 ILE A 302
ALA A 305
ALA A 306
LEU A 262
ALA A 265
 None
 0.95A 5z12B-5ve8A:
undetectable		 5z12B-5ve8A:
6.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnz CRED

(Streptomyces
cremeus) 		no annotation 5 ILE A  54
ALA A  57
ALA A  58
LEU A  30
ALA A  89
 None
 0.97A 5z12B-5xnzA:
undetectable		 5z12B-5xnzA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi RIBOSOMAL PROTEIN
S19E, PUTATIVE

(Trichomonas
vaginalis) 		PF01090
(Ribosomal_S19e) 		5 ILE T  68
ALA T  65
ALA T  64
LEU T  25
ALA T  26
 None
 0.98A 5z12B-5xyiT:
undetectable		 5z12B-5xyiT:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xym 50S RIBOSOMAL
PROTEIN L22

(Mycolicibacterium
smegmatis) 		PF00237
(Ribosomal_L22) 		5 ALA S  61
ALA S  62
LEU S  76
ALA S  10
LEU S  40
 None
 0.93A 5z12B-5xymS:
undetectable		 5z12B-5xymS:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c66 CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY

(Thermobifida
fusca) 		no annotation 5 ILE A  71
LEU A 273
ALA A 268
VAL A 182
LEU A  44
 None
 0.96A 5z12B-6c66A:
undetectable		 5z12B-6c66A:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d95 -

(-) 		no annotation 6 ILE A 129
ALA A 132
ALA A 133
LEU A 138
LEU A 267
ALA A 266
 None
 0.90A 5z12B-6d95A:
undetectable		 5z12B-6d95A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ak6 DESTRIN

(Homo sapiens;
Sus scrofa) 		PF00241
(Cofilin_ADF) 		3 GLN A 136
ILE A  55
HIS A  70
 None
 0.71A 5z12B-1ak6A:
undetectable		 5z12B-1ak6A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1amk TRIOSE PHOSPHATE
ISOMERASE

(Leishmania
mexicana) 		PF00121
(TIM) 		3 GLN A  52
ILE A 246
HIS A  31
 None
 0.61A 5z12B-1amkA:
undetectable		 5z12B-1amkA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1by7 PROTEIN (PLASMINOGEN
ACTIVATOR
INHIBITOR-2)

(Homo sapiens) 		PF00079
(Serpin) 		3 GLN A  59
ILE A 114
HIS A 400
 None
 0.58A 5z12B-1by7A:
0.0		 5z12B-1by7A:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		3 GLN A 157
ILE A 207
HIS A 205
 None
ZN  A 402 ( 4.8A)
ZN  A 402 (-3.4A)
 0.69A 5z12B-1fd9A:
undetectable		 5z12B-1fd9A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1khd ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Pectobacterium
carotovorum) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		3 GLN A  33
ILE A 194
HIS A 168
 None
 0.53A 5z12B-1khdA:
undetectable		 5z12B-1khdA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lg7 VSV MATRIX PROTEIN

(Vesicular
stomatitis
virus) 		PF06326
(Vesiculo_matrix) 		3 GLN A 128
ILE A 164
HIS A  90
 None
 0.70A 5z12B-1lg7A:
undetectable		 5z12B-1lg7A:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qrr SULFOLIPID
BIOSYNTHESIS (SQD1)
PROTEIN

(Arabidopsis
thaliana) 		PF01370
(Epimerase) 		3 GLN A 366
ILE A 376
HIS A 251
 None
 0.70A 5z12B-1qrrA:
0.0		 5z12B-1qrrA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sdd COAGULATION FACTOR V

(Bos taurus) 		PF07732
(Cu-oxidase_3) 		3 GLN A 246
ILE A 217
HIS A 183
 None
 0.67A 5z12B-1sddA:
undetectable		 5z12B-1sddA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 95 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF08519
(RFC1) 		3 GLN A 474
ILE A 422
HIS A 364
 None
 0.42A 5z12B-1sxjA:
undetectable		 5z12B-1sxjA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tk9 PHOSPHOHEPTOSE
ISOMERASE 1

(Campylobacter
jejuni) 		PF13580
(SIS_2) 		3 GLN A  19
ILE A 174
HIS A 178
 None
 0.68A 5z12B-1tk9A:
undetectable		 5z12B-1tk9A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tt4 PUTATIVE CYTOPLASMIC
PROTEIN

(Salmonella
enterica) 		PF04107
(GCS2) 		3 GLN A 258
ILE A 148
HIS A 152
 None
 0.68A 5z12B-1tt4A:
0.0		 5z12B-1tt4A:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tv8 MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A

(Staphylococcus
aureus) 		PF04055
(Radical_SAM)
PF06463
(Mob_synth_C)
PF13394
(Fer4_14) 		3 GLN A 249
ILE A 178
HIS A 223
 None
 0.64A 5z12B-1tv8A:
undetectable		 5z12B-1tv8A:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6g TIP120 PROTEIN

(Homo sapiens) 		PF08623
(TIP120) 		3 GLN C 544
ILE C 473
HIS C 516
 None
 0.70A 5z12B-1u6gC:
undetectable		 5z12B-1u6gC:
5.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uhl RETINOIC ACID
RECEPTOR RXR-BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		3 GLN A 346
ILE A 416
HIS A 506
 None
 0.57A 5z12B-1uhlA:
35.6		 5z12B-1uhlA:
80.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukr ENDO-1,4-B-XYLANASE
I

(Aspergillus
niger) 		PF00457
(Glyco_hydro_11) 		3 GLN A  77
ILE A  82
HIS A 148
 None
 0.68A 5z12B-1ukrA:
undetectable		 5z12B-1ukrA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wnh LATEXIN

(Mus musculus) 		PF06907
(Latexin) 		3 GLN A 150
ILE A 187
HIS A 185
 None
 0.48A 5z12B-1wnhA:
undetectable		 5z12B-1wnhA:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xiu RXR-LIKE PROTEIN

(Biomphalaria
glabrata) 		PF00104
(Hormone_recep) 		3 GLN A 249
ILE A 319
HIS A 409
 9CR  A 201 (-4.1A)
None
9CR  A 201 (-4.8A)
 0.39A 5z12B-1xiuA:
32.8		 5z12B-1xiuA:
73.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xls RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		3 GLN A 275
ILE A 345
HIS A 435
 9CR  A 801 (-4.7A)
9CR  A 801 ( 4.5A)
None
 0.49A 5z12B-1xlsA:
35.4		 5z12B-1xlsA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yb5 QUINONE
OXIDOREDUCTASE

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 GLN A 302
ILE A 316
HIS A 317
 None
 0.69A 5z12B-1yb5A:
undetectable		 5z12B-1yb5A:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zb1 BRO1 PROTEIN

(Saccharomyces
cerevisiae) 		PF03097
(BRO1) 		3 GLN A 130
ILE A 339
HIS A 182
 None
 0.69A 5z12B-1zb1A:
undetectable		 5z12B-1zb1A:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2akj FERREDOXIN--NITRITE
REDUCTASE,
CHLOROPLAST

(Spinacia
oleracea) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		3 GLN A 172
ILE A  86
HIS A  97
 None
 0.69A 5z12B-2akjA:
undetectable		 5z12B-2akjA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bo9 HUMAN LATEXIN

(Homo sapiens) 		PF06907
(Latexin) 		3 GLN B 150
ILE B 187
HIS B 185
 None
 0.64A 5z12B-2bo9B:
undetectable		 5z12B-2bo9B:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4e 5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
SEMIALDEHYDE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00171
(Aldedh) 		3 GLN A 116
ILE A 211
HIS A 102
 None
 0.67A 5z12B-2d4eA:
undetectable		 5z12B-2d4eA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dc0 PROBABLE AMIDASE

(Thermus
thermophilus) 		PF01425
(Amidase) 		3 GLN A 411
ILE A 228
HIS A 217
 None
 0.71A 5z12B-2dc0A:
undetectable		 5z12B-2dc0A:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dep THERMOSTABLE
CELLOXYLANASE

([Clostridium]
stercorarium) 		PF00331
(Glyco_hydro_10) 		3 GLN A 324
ILE A 279
HIS A 261
 None
 0.69A 5z12B-2depA:
undetectable		 5z12B-2depA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dlg FILAMIN-B

(Homo sapiens) 		PF00630
(Filamin) 		3 GLN A  86
ILE A  25
HIS A  57
 None
 0.69A 5z12B-2dlgA:
undetectable		 5z12B-2dlgA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f7v AECTYLCITRULLINE
DEACETYLASE

(Xanthomonas
campestris) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		3 GLN A  40
ILE A 104
HIS A  72
 None
CO  A5367 ( 4.7A)
CO  A5367 (-3.4A)
 0.56A 5z12B-2f7vA:
undetectable		 5z12B-2f7vA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hb6 LEUCINE
AMINOPEPTIDASE 1

(Caenorhabditis
elegans) 		PF00883
(Peptidase_M17) 		3 GLN A  43
ILE A  59
HIS A  65
 None
 0.61A 5z12B-2hb6A:
undetectable		 5z12B-2hb6A:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iir ACETATE KINASE

(Thermotoga
maritima) 		PF00871
(Acetate_kinase) 		3 GLN A 152
ILE A 130
HIS A  89
 None
 0.70A 5z12B-2iirA:
undetectable		 5z12B-2iirA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kvp TALIN-1

(Mus musculus) 		PF08913
(VBS) 		3 GLN A1888
ILE A1835
HIS A1925
 None
 0.68A 5z12B-2kvpA:
undetectable		 5z12B-2kvpA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lxn GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT A

(Methanocaldococcus
jannaschii) 		PF00117
(GATase) 		3 GLN A 146
ILE A  75
HIS A 163
 None
 0.64A 5z12B-2lxnA:
undetectable		 5z12B-2lxnA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w0m SSO2452

(Sulfolobus
solfataricus) 		PF06745
(ATPase) 		3 GLN A  17
ILE A 227
HIS A  42
 None
 0.68A 5z12B-2w0mA:
undetectable		 5z12B-2w0mA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1j PUTATIVE SORTASE

(Streptococcus
pneumoniae) 		PF04203
(Sortase) 		3 GLN A 106
ILE A  22
HIS A  84
 None
 0.69A 5z12B-2w1jA:
undetectable		 5z12B-2w1jA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 GLN A 749
ILE A 639
HIS A 621
 None
 0.57A 5z12B-3c4fA:
undetectable		 5z12B-3c4fA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3col PUTATIVE
TRANSCRIPTION
REGULATOR

(Lactobacillus
plantarum) 		PF00440
(TetR_N) 		3 GLN A  92
ILE A 144
HIS A 152
 None
 0.67A 5z12B-3colA:
undetectable		 5z12B-3colA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dpu RAB FAMILY PROTEIN

(Chlorobaculum
tepidum) 		PF08477
(Roc)
PF16095
(COR) 		3 GLN A 762
ILE A 703
HIS A 699
 None
 0.67A 5z12B-3dpuA:
undetectable		 5z12B-3dpuA:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3duh INTERLEUKIN-23
SUBUNIT ALPHA

(Homo sapiens) 		PF16649
(IL23) 		3 GLN C 151
ILE C  79
HIS C  75
 None
 0.67A 5z12B-3duhC:
undetectable		 5z12B-3duhC:
17.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		3 GLN A 275
ILE A 345
HIS A 435
 9CR  A7223 (-4.6A)
9CR  A7223 ( 4.9A)
9CR  A7223 (-4.3A)
 0.38A 5z12B-3dzuA:
33.8		 5z12B-3dzuA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb6 BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 3

(Homo sapiens) 		PF13920
(zf-C3HC4_3) 		3 GLN A 552
ILE A 590
HIS A 574
 None
ZN  A1002 ( 4.9A)
ZN  A1002 (-2.8A)
 0.62A 5z12B-3eb6A:
undetectable		 5z12B-3eb6A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eo7 PUTATIVE
NITROREDUCTASE

(Trichormus
variabilis) 		PF00881
(Nitroreductase) 		3 GLN A 144
ILE A 246
HIS A 207
 None
 0.64A 5z12B-3eo7A:
undetectable		 5z12B-3eo7A:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3euw MYO-INOSITOL
DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		3 GLN A  41
ILE A  13
HIS A  17
 None
 0.61A 5z12B-3euwA:
undetectable		 5z12B-3euwA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwj ARYLPHORIN

(Antheraea
pernyi) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 GLN A 652
ILE A 552
HIS A 543
 None
 0.58A 5z12B-3gwjA:
undetectable		 5z12B-3gwjA:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hs0 COBRA VENOM FACTOR

(Naja kaouthia) 		PF00207
(A2M) 		3 GLN B 847
ILE B 813
HIS B 815
 None
 0.65A 5z12B-3hs0B:
undetectable		 5z12B-3hs0B:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica) 		PF03063
(Prismane) 		3 GLN A 389
ILE A 356
HIS A 281
 None
 0.71A 5z12B-3i04A:
undetectable		 5z12B-3i04A:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jys SUSD SUPERFAMILY
PROTEIN

(Bacteroides
vulgatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 GLN A  91
ILE A 367
HIS A 338
 None
 0.70A 5z12B-3jysA:
undetectable		 5z12B-3jysA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kpt COLLAGEN ADHESION
PROTEIN

(Bacillus cereus) 		no annotation 3 GLN A 222
ILE A 173
HIS A 208
 None
 0.70A 5z12B-3kptA:
undetectable		 5z12B-3kptA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lca PROTEIN TOM71

(Saccharomyces
cerevisiae) 		PF00515
(TPR_1)
PF13181
(TPR_8)
PF14559
(TPR_19) 		3 GLN A 395
ILE A 382
HIS A 417
 None
 0.68A 5z12B-3lcaA:
undetectable		 5z12B-3lcaA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m2t PROBABLE
DEHYDROGENASE

(Chromobacterium
violaceum) 		PF01408
(GFO_IDH_MocA) 		3 GLN A  25
ILE A  52
HIS A  46
 None
None
SO4  A 359 (-3.6A)
 0.70A 5z12B-3m2tA:
undetectable		 5z12B-3m2tA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mes CHOLINE KINASE

(Cryptosporidium
parvum) 		PF01633
(Choline_kinase) 		3 GLN A  77
ILE A 140
HIS A 102
 None
 0.71A 5z12B-3mesA:
undetectable		 5z12B-3mesA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmk FUSION OF
LIM/HOMEOBOX PROTEIN
LHX4, LINKER,
INSULIN GENE
ENHANCER PROTEIN
ISL-2

(Mus musculus) 		PF00412
(LIM) 		3 GLN A 106
ILE A  96
HIS A 283
 None
 0.70A 5z12B-3mmkA:
undetectable		 5z12B-3mmkA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3moi PROBABLE
DEHYDROGENASE

(Bordetella
bronchiseptica) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		3 GLN A 341
ILE A 352
HIS A  90
 None
 0.71A 5z12B-3moiA:
undetectable		 5z12B-3moiA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nby SNURPORTIN-1

(Homo sapiens) 		PF11538
(Snurportin1) 		3 GLN B  15
ILE B 108
HIS B  24
 None
 0.70A 5z12B-3nbyB:
undetectable		 5z12B-3nbyB:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3no8 BTB/POZ
DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF08005
(PHR) 		3 GLN A 419
ILE A 412
HIS A 413
 None
 0.61A 5z12B-3no8A:
undetectable		 5z12B-3no8A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3no8 BTB/POZ
DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF08005
(PHR) 		3 GLN A 419
ILE A 412
HIS A 477
 None
 0.58A 5z12B-3no8A:
undetectable		 5z12B-3no8A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ocj PUTATIVE EXPORTED
PROTEIN

(Bordetella
parapertussis) 		PF13847
(Methyltransf_31) 		3 GLN A 212
ILE A 297
HIS A 112
 None
 0.71A 5z12B-3ocjA:
undetectable		 5z12B-3ocjA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3okf 3-DEHYDROQUINATE
SYNTHASE

(Vibrio cholerae) 		PF01761
(DHQ_synthase) 		3 GLN A 130
ILE A  58
HIS A  68
 None
 0.58A 5z12B-3okfA:
undetectable		 5z12B-3okfA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3prx COBRA VENOM FACTOR

(Naja kaouthia) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		3 GLN B 869
ILE B 835
HIS B 837
 None
 0.56A 5z12B-3prxB:
undetectable		 5z12B-3prxB:
4.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q2k OXIDOREDUCTASE

(Bordetella
pertussis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		3 GLN A  50
ILE A  21
HIS A  25
 None
NAI  A 500 (-3.6A)
None
 0.67A 5z12B-3q2kA:
undetectable		 5z12B-3q2kA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Coxiella
burnetii) 		PF00275
(EPSP_synthase) 		3 GLN A 169
ILE A 228
HIS A 203
 PO4  A 442 ( 4.1A)
None
None
 0.52A 5z12B-3tr1A:
undetectable		 5z12B-3tr1A:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr7 URACIL-DNA
GLYCOSYLASE

(Coxiella
burnetii) 		PF03167
(UDG) 		3 GLN A 175
ILE A  59
HIS A 157
 None
 0.56A 5z12B-3tr7A:
undetectable		 5z12B-3tr7A:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 GLN A 749
ILE A 639
HIS A 621
 None
 0.69A 5z12B-3tt0A:
undetectable		 5z12B-3tt0A:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uaf TTR-52

(Caenorhabditis
elegans) 		PF01060
(TTR-52) 		3 GLN A  73
ILE A 108
HIS A  95
 None
 0.63A 5z12B-3uafA:
undetectable		 5z12B-3uafA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vil BETA-GLUCOSIDASE

(Neotermes
koshunensis) 		PF00232
(Glyco_hydro_1) 		3 GLN A 316
ILE A 285
HIS A 229
 None
 0.70A 5z12B-3vilA:
undetectable		 5z12B-3vilA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3voc BETA/ALPHA-AMYLASE

(Paenibacillus
polymyxa) 		PF01373
(Glyco_hydro_14) 		3 GLN A 132
ILE A 276
HIS A 265
 CA  A 501 (-2.9A)
None
EDO  A 505 ( 4.2A)
 0.71A 5z12B-3vocA:
undetectable		 5z12B-3vocA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13

(Mycobacterium
tuberculosis) 		PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N) 		3 GLN A 168
ILE A 156
HIS A 213
 None
 0.69A 5z12B-3zukA:
undetectable		 5z12B-3zukA:
8.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4arp PESTICIN

(Yersinia pestis) 		PF16754
(Pesticin) 		3 GLN A 301
ILE A 166
HIS A 269
 None
 0.68A 5z12B-4arpA:
undetectable		 5z12B-4arpA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eei ADENYLOSUCCINATE
LYASE

(Francisella
tularensis) 		PF00206
(Lyase_1) 		3 GLN A  52
ILE A  97
HIS A  89
 None
 0.67A 5z12B-4eeiA:
undetectable		 5z12B-4eeiA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ege DIPEPTIDASE PEPE

(Mycobacterium
ulcerans) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		3 GLN A 142
ILE A 308
HIS A 306
 None
None
ZN  A 411 (-3.3A)
 0.69A 5z12B-4egeA:
undetectable		 5z12B-4egeA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f52 E3 UBIQUITIN-PROTEIN
LIGASE RBX1
GLOMULIN

(Homo sapiens) 		PF08568
(Kinetochor_Ybp2)
PF12678
(zf-rbx1) 		3 GLN E 427
ILE B  37
HIS E 413
 None
 0.70A 5z12B-4f52E:
undetectable		 5z12B-4f52E:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fhn NUCLEOPORIN NUP120

(Schizosaccharomyces
pombe) 		PF11715
(Nup160) 		3 GLN B 267
ILE B 195
HIS B 204
 None
 0.62A 5z12B-4fhnB:
undetectable		 5z12B-4fhnB:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g56 HSL7 PROTEIN

(Xenopus laevis) 		PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		3 GLN A 259
ILE A 231
HIS A 246
 None
 0.59A 5z12B-4g56A:
undetectable		 5z12B-4g56A:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ggj MITOCHONDRIAL
CARDIOLIPIN
HYDROLASE

(Mus musculus) 		PF13091
(PLDc_2) 		3 GLN A 102
ILE A 141
HIS A 111
 None
 0.62A 5z12B-4ggjA:
undetectable		 5z12B-4ggjA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gnj TRIOSEPHOSPHATE
ISOMERASE

(Leishmania sp.
'siamensis') 		PF00121
(TIM) 		3 GLN A  53
ILE A 247
HIS A  32
 None
 0.53A 5z12B-4gnjA:
undetectable		 5z12B-4gnjA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gqb PROTEIN ARGININE
N-METHYLTRANSFERASE
5

(Homo sapiens) 		PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		3 GLN A 263
ILE A 235
HIS A 250
 None
 0.57A 5z12B-4gqbA:
undetectable		 5z12B-4gqbA:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j35 PHOSPHOTRIESTERASE,
PUTATIVE

(Deinococcus
radiodurans) 		PF02126
(PTE) 		3 GLN A  62
ILE A 296
HIS A 291
 None
 0.68A 5z12B-4j35A:
undetectable		 5z12B-4j35A:
13.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4j5x RETINOIC ACID
RECEPTOR RXR-ALPHA,
NUCLEAR RECEPTOR
COACTIVATOR 1

(Homo sapiens) 		no annotation 3 GLN D 275
ILE D 345
HIS D 435
 None
 0.50A 5z12B-4j5xD:
34.2		 5z12B-4j5xD:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jc8 HOPS COMPONENT VPS33

(Chaetomium
thermophilum) 		PF00995
(Sec1) 		3 GLN A 464
ILE A 651
HIS A 453
 None
 0.70A 5z12B-4jc8A:
undetectable		 5z12B-4jc8A:
7.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4or8 MEMBRANE-ASSOCIATED
PROTEIN VP24

(Marburg
marburgvirus) 		PF06389
(Filo_VP24) 		3 GLN A  71
ILE A  87
HIS A  58
 None
 0.68A 5z12B-4or8A:
undetectable		 5z12B-4or8A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8g UNCONVENTIONAL
MYOSIN-IC

(Mus musculus) 		PF00612
(IQ)
PF06017
(Myosin_TH1) 		3 GLN E 960
ILE E 999
HIS E1017
 None
 0.64A 5z12B-4r8gE:
undetectable		 5z12B-4r8gE:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		3 GLN A 356
ILE A 321
HIS A 432
 None
 0.65A 5z12B-4w8jA:
undetectable		 5z12B-4w8jA:
5.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhy FLAVIN REDUCTASE
DOMAIN PROTEIN,
FMN-BINDING PROTEIN

(Paracoccus
denitrificans) 		PF01613
(Flavin_Reduct) 		3 GLN A 175
ILE A 126
HIS A  91
 None
 0.68A 5z12B-4xhyA:
undetectable		 5z12B-4xhyA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ywe PUTATIVE ALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		3 GLN A 255
ILE A 344
HIS A 375
 None
 0.63A 5z12B-4yweA:
undetectable		 5z12B-4yweA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0c TOLL-LIKE RECEPTOR
13

(Mus musculus) 		PF00560
(LRR_1)
PF13516
(LRR_6)
PF13855
(LRR_8) 		3 GLN A 698
ILE A 710
HIS A 714
 None
 0.48A 5z12B-4z0cA:
undetectable		 5z12B-4z0cA:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zg5 5'-NUCLEOTIDASE SURE

(Brucella
abortus) 		no annotation 3 GLN D 125
ILE D  11
HIS D  12
 None
 0.70A 5z12B-4zg5D:
undetectable		 5z12B-4zg5D:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF

(Serratia sp.
FS14) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		3 GLN A 175
ILE A 126
HIS A  48
 None
None
ZN  A 801 (-3.2A)
 0.53A 5z12B-5cioA:
undetectable		 5z12B-5cioA:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF

(Serratia sp.
FS14) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		3 GLN A 175
ILE A 126
HIS A  52
 None
None
ZN  A 801 (-3.2A)
 0.52A 5z12B-5cioA:
undetectable		 5z12B-5cioA:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dis SNURPORTIN-1

(Homo sapiens) 		PF11538
(Snurportin1) 		3 GLN C  16
ILE C 109
HIS C  25
 None
 0.62A 5z12B-5disC:
undetectable		 5z12B-5disC:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5edx CD8 ALPHA ANTIGEN

(Sus scrofa) 		PF07686
(V-set) 		3 GLN A  11
ILE A  80
HIS A  82
 None
 0.68A 5z12B-5edxA:
undetectable		 5z12B-5edxA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exr DNA PRIMASE LARGE
SUBUNIT

(Homo sapiens) 		PF04104
(DNA_primase_lrg) 		3 GLN B 446
ILE B 276
HIS B 292
 None
 0.68A 5z12B-5exrB:
undetectable		 5z12B-5exrB:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h11 UNCHARACTERIZED
PROTEIN

(Danio rerio) 		PF07393
(Sec10) 		3 GLN A 620
ILE A 632
HIS A 658
 None
 0.68A 5z12B-5h11A:
undetectable		 5z12B-5h11A:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h42 UNCHARACTERIZED
PROTEIN

(Lachnoclostridium
phytofermentans) 		PF17167
(Glyco_hydro_36) 		3 GLN A 144
ILE A 252
HIS A 248
 None
 0.68A 5z12B-5h42A:
undetectable		 5z12B-5h42A:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k3h ACYL-COENZYME A
OXIDASE

(Caenorhabditis
elegans) 		PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N) 		3 GLN A 355
ILE A 488
HIS A 568
 None
 0.53A 5z12B-5k3hA:
undetectable		 5z12B-5k3hA:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbc DSBA

(Chlamydia
trachomatis) 		PF13462
(Thioredoxin_4) 		3 GLN A 149
ILE A 137
HIS A  88
 None
 0.71A 5z12B-5kbcA:
undetectable		 5z12B-5kbcA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lwg VP3

(Israeli acute
paralysis virus) 		no annotation 3 GLN C  78
ILE C  91
HIS C  67
 None
 0.63A 5z12B-5lwgC:
undetectable		 5z12B-5lwgC:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tjt MAJOR CAPSID PROTEIN

(Escherichia
virus T5) 		PF05065
(Phage_capsid) 		3 GLN A 187
ILE A 283
HIS A 279
 None
 0.66A 5z12B-5tjtA:
undetectable		 5z12B-5tjtA:
15.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uan RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		no annotation 3 GLN A 275
ILE A 345
HIS A 435
 9CR  A 503 (-3.8A)
None
None
 0.43A 5z12B-5uanA:
34.4		 5z12B-5uanA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uki RNA LARIAT
DEBRANCHING ENZYME,
PUTATIVE

(Entamoeba
histolytica) 		no annotation 3 GLN A 184
ILE A 245
HIS A 236
 None
 0.60A 5z12B-5ukiA:
undetectable		 5z12B-5ukiA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v7q 50S RIBOSOMAL
PROTEIN L19

(Mycobacterium
tuberculosis) 		PF01245
(Ribosomal_L19) 		3 GLN P  40
ILE P  16
HIS P  76
 None
 0.60A 5z12B-5v7qP:
undetectable		 5z12B-5v7qP:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cet GATOR COMPLEX
PROTEIN NPRL2
GATOR COMPLEX
PROTEIN NPRL3

(Homo sapiens) 		no annotation 3 GLN N 240
ILE N 206
HIS M 518
 None
 0.56A 5z12B-6cetN:
undetectable		 5z12B-6cetN:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmn TAR-BINDING PROTEIN
6.7

(Oryctolagus
cuniculus) 		no annotation 3 GLN A  54
ILE A  40
HIS A  31
 A  D  35 ( 2.9A)
None
None
 0.60A 5z12B-6cmnA:
undetectable		 5z12B-6cmnA:
15.66