SIMILAR PATTERNS OF AMINO ACIDS FOR 5Z0K_B_DAHB98_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bt2 | PROTEIN (CATECHOLOXIDASE) (Ipomoea batatas) |
PF00264(Tyrosinase)PF12142(PPO1_DWL) | 5 | HIS A 240HIS A 244HIS A 88HIS A 109ASP A 17 | C2O A 500 ( 3.2A)C2O A 500 ( 3.2A)C2O A 500 ( 3.2A)C2O A 500 ( 3.3A)None | 1.21A | 5z0kA-1bt2A:20.85z0kB-1bt2A:undetectable | 5z0kA-1bt2A:13.045z0kB-1bt2A:12.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bt2 | PROTEIN (CATECHOLOXIDASE) (Ipomoea batatas) |
PF00264(Tyrosinase)PF12142(PPO1_DWL) | 5 | HIS A 240HIS A 244HIS A 88HIS A 109PRO A 19 | C2O A 500 ( 3.2A)C2O A 500 ( 3.2A)C2O A 500 ( 3.2A)C2O A 500 ( 3.3A)None | 1.21A | 5z0kA-1bt2A:20.85z0kB-1bt2A:undetectable | 5z0kA-1bt2A:13.045z0kB-1bt2A:12.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fwx | NITROUS OXIDEREDUCTASE (Paracoccusdenitrificans) |
PF13473(Cupredoxin_1) | 5 | HIS A 128HIS A 80HIS A 325ASN A 273VAL A 283 | CUZ A4801 (-3.2A)CUZ A4801 (-3.3A)CUZ A4801 ( 3.3A) CL A4901 (-3.5A)None | 1.19A | 5z0kA-1fwxA:undetectable5z0kB-1fwxA:0.6 | 5z0kA-1fwxA:9.595z0kB-1fwxA:9.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hcy | ARTHROPODANHEMOCYANIN (Panulirusinterruptus) |
PF00372(Hemocyanin_M)PF03722(Hemocyanin_N)PF03723(Hemocyanin_C) | 6 | HIS A 194HIS A 198HIS A 344ASN A 345HIS A 348VAL A 349 | CU A 665 (-3.0A) CU A 665 (-3.1A) CU A 666 (-3.1A)None CU A 666 (-3.8A)None | 0.71A | 5z0kA-1hcyA:9.65z0kB-1hcyA:0.0 | 5z0kA-1hcyA:9.385z0kB-1hcyA:8.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hmd | HEMERYTHRIN (Themistedyscritum) |
no annotation | 5 | HIS A 25HIS A 54HIS A 73HIS A 101ASP A 79 | FEO A 115 (-3.3A)FEO A 115 (-3.5A)FEO A 115 (-3.4A)FEO A 115 (-3.4A)None | 1.45A | 5z0kA-1hmdA:undetectable5z0kB-1hmdA:undetectable | 5z0kA-1hmdA:20.695z0kB-1hmdA:15.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hmd | HEMERYTHRIN (Themistedyscritum) |
no annotation | 5 | HIS A 54ILE A 21HIS A 25HIS A 101HIS A 77 | FEO A 115 (-3.5A)NoneFEO A 115 (-3.3A)FEO A 115 (-3.4A)FEO A 115 (-3.4A) | 1.37A | 5z0kA-1hmdA:undetectable5z0kB-1hmdA:undetectable | 5z0kA-1hmdA:20.695z0kB-1hmdA:15.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1js8 | HEMOCYANIN (Enteroctopusdofleini) |
PF00264(Tyrosinase)PF14830(Haemocyan_bet_s) | 5 | HIS A2543HIS A2562HIS A2671ASN A2672HIS A2675 | CUO A 888 (-3.4A)CUO A 888 (-3.4A)CUO A 888 (-3.4A)NoneCUO A 888 (-3.3A) | 0.54A | 5z0kA-1js8A:23.05z0kB-1js8A:0.0 | 5z0kA-1js8A:9.575z0kB-1js8A:11.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1js8 | HEMOCYANIN (Enteroctopusdofleini) |
PF00264(Tyrosinase)PF14830(Haemocyan_bet_s) | 5 | HIS A2543HIS A2571HIS A2671ASN A2672HIS A2675 | CUO A 888 (-3.4A)CUO A 888 (-3.3A)CUO A 888 (-3.4A)NoneCUO A 888 (-3.3A) | 1.49A | 5z0kA-1js8A:23.05z0kB-1js8A:0.0 | 5z0kA-1js8A:9.575z0kB-1js8A:11.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1js8 | HEMOCYANIN (Enteroctopusdofleini) |
PF00264(Tyrosinase)PF14830(Haemocyan_bet_s) | 5 | HIS A2562HIS A2543HIS A2675HIS A2671ASP A2706 | CUO A 888 (-3.4A)CUO A 888 (-3.4A)CUO A 888 (-3.3A)CUO A 888 (-3.4A)None | 1.41A | 5z0kA-1js8A:23.05z0kB-1js8A:0.0 | 5z0kA-1js8A:9.575z0kB-1js8A:11.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kcw | CERULOPLASMIN (Homo sapiens) |
PF00394(Cu-oxidase)PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 5 | HIS A 161HIS A1020HIS A 980ASP A 118PRO A 117 | CU A1051 (-3.3A) CU A1050 (-3.2A) CU A1050 (-3.0A)NoneNone | 1.15A | 5z0kA-1kcwA:undetectable5z0kB-1kcwA:0.0 | 5z0kA-1kcwA:6.245z0kB-1kcwA:5.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lla | HEMOCYANIN (SUBUNITTYPE II) (Limuluspolyphemus) |
PF00372(Hemocyanin_M)PF03722(Hemocyanin_N)PF03723(Hemocyanin_C) | 8 | HIS A 173HIS A 177HIS A 324ASN A 325HIS A 328VAL A 329SER A 354PRO A 51 | CU A 629 (-3.2A) CU A 629 (-3.2A) CU A 630 (-3.3A)None CU A 630 (-3.2A) CL A 632 ( 3.7A)NoneNone | 0.88A | 5z0kA-1llaA:9.15z0kB-1llaA:0.0 | 5z0kA-1llaA:10.395z0kB-1llaA:8.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lla | HEMOCYANIN (SUBUNITTYPE II) (Limuluspolyphemus) |
PF00372(Hemocyanin_M)PF03722(Hemocyanin_N)PF03723(Hemocyanin_C) | 5 | HIS A 328HIS A 324HIS A 177HIS A 173SER A 354 | CU A 630 (-3.2A) CU A 630 (-3.3A) CU A 629 (-3.2A) CU A 629 (-3.2A)None | 1.03A | 5z0kA-1llaA:9.15z0kB-1llaA:0.0 | 5z0kA-1llaA:10.395z0kB-1llaA:8.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lnl | HEMOCYANIN (Rapana venosa) |
PF00264(Tyrosinase)PF14830(Haemocyan_bet_s) | 6 | HIS A 41HIS A 61HIS A 181ASN A 182HIS A 185ASP A 341 | CU A5001 (-2.9A) CU A5001 (-3.6A) CU A5012 (-3.4A)None CU A5012 (-3.2A)None | 1.18A | 5z0kA-1lnlA:0.05z0kB-1lnlA:undetectable | 5z0kA-1lnlA:13.205z0kB-1lnlA:12.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lnl | HEMOCYANIN (Rapana venosa) |
PF00264(Tyrosinase)PF14830(Haemocyan_bet_s) | 5 | HIS A 41HIS A 70HIS A 181ASN A 182HIS A 185 | CU A5001 (-2.9A) CU A5001 ( 3.1A) CU A5012 (-3.4A)None CU A5012 (-3.2A) | 1.45A | 5z0kA-1lnlA:0.05z0kB-1lnlA:undetectable | 5z0kA-1lnlA:13.205z0kB-1lnlA:12.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lnl | HEMOCYANIN (Rapana venosa) |
PF00264(Tyrosinase)PF14830(Haemocyan_bet_s) | 5 | HIS A 61HIS A 41HIS A 185HIS A 181ASP A 216 | CU A5001 (-3.6A) CU A5001 (-2.9A) CU A5012 (-3.2A) CU A5012 (-3.4A)None | 1.36A | 5z0kA-1lnlA:0.05z0kB-1lnlA:undetectable | 5z0kA-1lnlA:13.205z0kB-1lnlA:12.29 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1wx4 | TYROSINASE (Streptomycescastaneoglobisporus) |
PF00264(Tyrosinase) | 8 | HIS A 38ILE A 42HIS A 54HIS A 190ASN A 191HIS A 194VAL A 195SER A 206 | CU A 400 ( 3.3A)None CU A 400 ( 3.3A) CU A 401 ( 3.2A)None CU A 401 ( 3.2A)NonePER A 409 ( 4.1A) | 0.18A | 5z0kA-1wx4A:49.85z0kB-1wx4A:undetectable | 5z0kA-1wx4A:100.005z0kB-1wx4A:15.12 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1wx4 | TYROSINASE (Streptomycescastaneoglobisporus) |
PF00264(Tyrosinase) | 5 | HIS A 194HIS A 190HIS A 54HIS A 38SER A 206 | CU A 401 ( 3.2A) CU A 401 ( 3.2A) CU A 400 ( 3.3A) CU A 400 ( 3.3A)PER A 409 ( 4.1A) | 0.99A | 5z0kA-1wx4A:49.85z0kB-1wx4A:undetectable | 5z0kA-1wx4A:100.005z0kB-1wx4A:15.12 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1wx4 | TYROSINASE (Streptomycescastaneoglobisporus) |
PF00264(Tyrosinase) | 5 | HIS A 194HIS A 190HIS A 63HIS A 38SER A 206 | CU A 401 ( 3.2A) CU A 401 ( 3.2A) CU A 400 ( 3.5A) CU A 400 ( 3.3A)PER A 409 ( 4.1A) | 1.45A | 5z0kA-1wx4A:49.85z0kB-1wx4A:undetectable | 5z0kA-1wx4A:100.005z0kB-1wx4A:15.12 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1wx4 | TYROSINASE (Streptomycescastaneoglobisporus) |
PF00264(Tyrosinase) | 5 | HIS A 194HIS A 216HIS A 54HIS A 38SER A 206 | CU A 401 ( 3.2A) CU A 401 ( 3.4A) CU A 400 ( 3.3A) CU A 400 ( 3.3A)PER A 409 ( 4.1A) | 1.35A | 5z0kA-1wx4A:49.85z0kB-1wx4A:undetectable | 5z0kA-1wx4A:100.005z0kB-1wx4A:15.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ys4 | ASPARTATE-SEMIALDEHYDE DEHYDROGENASE (Methanocaldococcusjannaschii) |
PF01118(Semialdhyde_dh)PF02774(Semialdhyde_dhC) | 5 | ILE A 335VAL A 313HIS A 332ASP A 303PRO A 300 | None | 1.27A | 5z0kA-1ys4A:undetectable5z0kB-1ys4A:0.0 | 5z0kA-1ys4A:11.855z0kB-1ys4A:13.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p3x | POLYPHENOL OXIDASE,CHLOROPLAST (Vitis vinifera) |
PF00264(Tyrosinase)PF12142(PPO1_DWL) | 5 | HIS A 87HIS A 108HIS A 239ASN A 240HIS A 243 | C2O A 340 (-3.2A)C2O A 340 (-3.3A)C2O A 340 (-3.2A)NoneC2O A 340 (-3.3A) | 0.36A | 5z0kA-2p3xA:21.15z0kB-2p3xA:undetectable | 5z0kA-2p3xA:14.515z0kB-2p3xA:14.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p3x | POLYPHENOL OXIDASE,CHLOROPLAST (Vitis vinifera) |
PF00264(Tyrosinase)PF12142(PPO1_DWL) | 5 | HIS A 239HIS A 243HIS A 87HIS A 108PRO A 17 | C2O A 340 (-3.2A)C2O A 340 (-3.3A)C2O A 340 (-3.2A)C2O A 340 (-3.3A)None | 1.18A | 5z0kA-2p3xA:21.15z0kB-2p3xA:undetectable | 5z0kA-2p3xA:14.515z0kB-2p3xA:14.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2uzx | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homo sapiens) |
PF01403(Sema)PF01437(PSI)PF01833(TIG) | 5 | HIS B 144ILE B 70VAL B 136SER B 132PRO B 88 | None | 1.38A | 5z0kA-2uzxB:undetectable5z0kB-2uzxB:undetectable | 5z0kA-2uzxB:8.485z0kB-2uzxB:6.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y9x | POLYPHENOL OXIDASE (Agaricusbisporus) |
PF00264(Tyrosinase) | 5 | HIS A 61HIS A 85HIS A 259ASN A 260HIS A 263 | CU A 400 (-3.2A) CU A 400 (-3.3A) CU A 401 (-3.2A)0TR A 410 (-4.1A)0TR A 410 ( 3.1A) | 0.35A | 5z0kA-2y9xA:20.35z0kB-2y9xA:undetectable | 5z0kA-2y9xA:9.925z0kB-2y9xA:12.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z23 | PERIPLASMICOLIGOPEPTIDE-BINDINGPROTEIN (Yersinia pestis) |
PF00496(SBP_bac_5) | 5 | HIS A 508ASN A 50VAL A 48SER A 165HIS A 161 | None | 1.40A | 5z0kA-2z23A:undetectable5z0kB-2z23A:undetectable | 5z0kA-2z23A:16.235z0kB-2z23A:10.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zbv | UNCHARACTERIZEDCONSERVED PROTEIN (Thermotogamaritima) |
PF01887(SAM_adeno_trans) | 5 | ILE A 176ASN A 42VAL A 67ASP A 7PRO A 40 | NoneNoneADN A 501 (-4.3A)ADN A 501 (-3.0A)None | 1.48A | 5z0kA-2zbvA:undetectable5z0kB-2zbvA:undetectable | 5z0kA-2zbvA:15.715z0kB-2zbvA:14.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d19 | CONSERVEDMETALLOPROTEIN (Bacillus cereus) |
PF11155(DUF2935) | 5 | HIS A 124ILE A 161HIS A 165HIS A 255HIS A 37 | MG A 301 (-3.5A) MG A 301 ( 4.6A) MG A 301 (-3.4A) FE A 302 (-3.5A) FE A 302 (-3.4A) | 1.30A | 5z0kA-3d19A:undetectable5z0kB-3d19A:undetectable | 5z0kA-3d19A:15.945z0kB-3d19A:12.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d19 | CONSERVEDMETALLOPROTEIN (Bacillus cereus) |
PF11155(DUF2935) | 5 | HIS A 255ILE A 33HIS A 37HIS A 124HIS A 165 | FE A 302 (-3.5A) FE A 302 (-4.3A) FE A 302 (-3.4A) MG A 301 (-3.5A) MG A 301 (-3.4A) | 1.31A | 5z0kA-3d19A:undetectable5z0kB-3d19A:undetectable | 5z0kA-3d19A:15.945z0kB-3d19A:12.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dcp | HISTIDINOL-PHOSPHATASE (Listeriamonocytogenes) |
PF02811(PHP)PF13263(PHP_C) | 5 | HIS A 123HIS A 181HIS A 6HIS A 8ASP A 264 | FE A 310 (-3.3A) FE A 310 (-3.5A) FE A 311 (-3.3A) FE A 311 (-3.4A)None | 1.16A | 5z0kA-3dcpA:undetectable5z0kB-3dcpA:undetectable | 5z0kA-3dcpA:14.815z0kB-3dcpA:15.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hhs | PHENOLOXIDASESUBUNIT 1 (Manduca sexta) |
PF00372(Hemocyanin_M)PF03722(Hemocyanin_N)PF03723(Hemocyanin_C) | 6 | HIS B 209HIS B 213HIS B 366ASN B 367HIS B 370VAL B 371 | CU B 686 (-3.1A) CU B 686 (-3.3A) CU B 1 (-3.3A)None CU B 1 (-3.2A)None | 0.65A | 5z0kA-3hhsB:10.05z0kB-3hhsB:undetectable | 5z0kA-3hhsB:10.025z0kB-3hhsB:8.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hhs | PHENOLOXIDASESUBUNIT 1 (Manduca sexta) |
PF00372(Hemocyanin_M)PF03722(Hemocyanin_N)PF03723(Hemocyanin_C) | 5 | HIS B 209HIS B 366ASN B 367HIS B 370PRO B 87 | CU B 686 (-3.1A) CU B 1 (-3.3A)None CU B 1 (-3.2A)None | 1.00A | 5z0kA-3hhsB:10.05z0kB-3hhsB:undetectable | 5z0kA-3hhsB:10.025z0kB-3hhsB:8.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hhs | PHENOLOXIDASESUBUNIT 1 (Manduca sexta) |
PF00372(Hemocyanin_M)PF03722(Hemocyanin_N)PF03723(Hemocyanin_C) | 5 | HIS B 366HIS B 239HIS B 209VAL B 389ASP B 399 | CU B 1 (-3.3A) CU B 686 (-3.1A) CU B 686 (-3.1A)NoneNone | 1.47A | 5z0kA-3hhsB:10.05z0kB-3hhsB:undetectable | 5z0kA-3hhsB:10.025z0kB-3hhsB:8.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hhs | PHENOLOXIDASESUBUNIT 2 (Manduca sexta) |
PF00372(Hemocyanin_M)PF03722(Hemocyanin_N)PF03723(Hemocyanin_C) | 5 | HIS A 215HIS A 219HIS A 368ASN A 369HIS A 372 | CU A 696 (-3.2A) CU A 696 (-3.3A) CU A 697 (-3.2A)None CU A 697 (-3.2A) | 0.69A | 5z0kA-3hhsA:8.05z0kB-3hhsA:undetectable | 5z0kA-3hhsA:10.095z0kB-3hhsA:8.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ixw | HEMOCYANIN AA6 CHAIN (Androctonusaustralis) |
PF00372(Hemocyanin_M)PF03722(Hemocyanin_N)PF03723(Hemocyanin_C) | 5 | HIS A 170HIS A 321ASN A 322HIS A 325SER A 351 | None | 0.72A | 5z0kA-3ixwA:8.35z0kB-3ixwA:undetectable | 5z0kA-3ixwA:11.095z0kB-3ixwA:9.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ixw | HEMOCYANIN AA6 CHAIN (Androctonusaustralis) |
PF00372(Hemocyanin_M)PF03722(Hemocyanin_N)PF03723(Hemocyanin_C) | 5 | HIS A 170HIS A 321ASN A 322HIS A 325VAL A 326 | None | 0.58A | 5z0kA-3ixwA:8.35z0kB-3ixwA:undetectable | 5z0kA-3ixwA:11.095z0kB-3ixwA:9.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lm4 | CATECHOL2,3-DIOXYGENASE (Rhodococcusjostii) |
PF00903(Glyoxalase) | 5 | HIS A 249HIS A 217ASN A 157HIS A 155VAL A 202 | HPX A 406 (-3.4A) FE A 400 ( 3.4A)PEO A 401 ( 4.1A) FE A 400 ( 3.5A)None | 1.22A | 5z0kA-3lm4A:undetectable5z0kB-3lm4A:undetectable | 5z0kA-3lm4A:12.065z0kB-3lm4A:12.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rpc | POSSIBLEMETAL-DEPENDENTHYDROLASE (Veillonellaparvula) |
PF12706(Lactamase_B_2) | 5 | HIS A 129HIS A 223ASN A 9HIS A 74PRO A 47 | ZN A 301 (-3.3A) ZN A 302 (-3.5A)None ZN A 302 (-3.4A)None | 1.31A | 5z0kA-3rpcA:undetectable5z0kB-3rpcA:undetectable | 5z0kA-3rpcA:13.305z0kB-3rpcA:15.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rqz | METALLOPHOSPHOESTERASE (Sphaerobacterthermophilus) |
PF12850(Metallophos_2) | 5 | HIS A 10HIS A 149HIS A 147HIS A 114VAL A 113 | ZN A 301 (-3.4A) ZN A 301 (-3.5A) ZN A 302 (-3.3A) ZN A 302 (-4.2A)None | 1.21A | 5z0kA-3rqzA:undetectable5z0kB-3rqzA:undetectable | 5z0kA-3rqzA:21.355z0kB-3rqzA:16.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u9j | F-BOX/LRR-REPEATPROTEIN 5 (Homo sapiens) |
PF01814(Hemerythrin) | 5 | HIS A 57HIS A 15HIS A 126HIS A 80VAL A 79 | FE A 201 (-3.4A) FE A 201 (-3.3A) FE A 200 (-3.5A) FE A 200 (-3.4A)None | 1.45A | 5z0kA-3u9jA:undetectable5z0kB-3u9jA:undetectable | 5z0kA-3u9jA:18.125z0kB-3u9jA:16.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ulk | KETOL-ACIDREDUCTOISOMERASE (Escherichiacoli) |
PF01450(IlvC)PF07991(IlvN) | 5 | ASN A 181HIS A 178VAL A 177ASP A 182PRO A 183 | ASN A 181 ( 0.6A)HIS A 178 ( 1.0A)VAL A 177 ( 0.6A)ASP A 182 ( 0.6A)PRO A 183 ( 1.1A) | 0.97A | 5z0kA-3ulkA:undetectable5z0kB-3ulkA:undetectable | 5z0kA-3ulkA:10.715z0kB-3ulkA:10.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uss | PUTATIVEUNCHARACTERIZEDPROTEIN (Pseudomonasaeruginosa) |
PF05995(CDO_I) | 5 | HIS A 142HIS A 91HIS A 157VAL A 131SER A 106 | FE2 A 212 (-3.3A)FE2 A 212 ( 3.2A)SO4 A 215 (-4.1A)NoneNone | 1.18A | 5z0kA-3ussA:undetectable5z0kB-3ussA:undetectable | 5z0kA-3ussA:17.545z0kB-3ussA:17.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v7p | AMIDOHYDROLASEFAMILY PROTEIN (Nitratiruptorsp. SB155-2) |
PF01979(Amidohydro_1) | 5 | HIS A 63ILE A 119HIS A 61HIS A 257PRO A 181 | FE A 429 (-3.2A)None FE A 429 (-3.2A)NoneNone | 1.48A | 5z0kA-3v7pA:undetectable5z0kB-3v7pA:undetectable | 5z0kA-3v7pA:10.455z0kB-3v7pA:9.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wky | PROPHENOLOXIDASE B (Marsupenaeusjaponicus) |
PF00372(Hemocyanin_M)PF03722(Hemocyanin_N)PF03723(Hemocyanin_C) | 5 | HIS A 199HIS A 203HIS A 357ASN A 358HIS A 361 | CUO A 708 (-3.3A)CUO A 708 (-3.5A)CUO A 708 (-3.3A)NoneCUO A 708 (-3.2A) | 0.72A | 5z0kA-3wkyA:10.55z0kB-3wkyA:undetectable | 5z0kA-3wkyA:8.135z0kB-3wkyA:8.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bed | HEMOCYANIN KLH1 (Megathuracrenulata) |
PF00264(Tyrosinase)PF14830(Haemocyan_bet_s) | 5 | HIS A 42HIS A 69HIS A 179ASN A 180HIS A 183 | CUO A9001 (-3.4A)CUO A9001 (-3.1A)CUO A9001 (-3.4A)NoneCUO A9001 (-3.4A) | 1.46A | 5z0kA-4bedA:20.45z0kB-4bedA:undetectable | 5z0kA-4bedA:5.495z0kB-4bedA:4.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bed | HEMOCYANIN KLH1 (Megathuracrenulata) |
PF00264(Tyrosinase)PF14830(Haemocyan_bet_s) | 5 | HIS A 462HIS A 482HIS A 602ASN A 603HIS A 606 | CUO A9002 (-3.2A)CUO A9002 (-3.4A)CUO A9002 (-3.4A)NoneCUO A9002 (-3.3A) | 1.00A | 5z0kA-4bedA:20.45z0kB-4bedA:undetectable | 5z0kA-4bedA:5.495z0kB-4bedA:4.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bed | HEMOCYANIN KLH1 (Megathuracrenulata) |
PF00264(Tyrosinase)PF14830(Haemocyan_bet_s) | 5 | HIS A 462HIS A 491HIS A 602ASN A 603HIS A 606 | CUO A9002 (-3.2A)CUO A9002 (-3.4A)CUO A9002 (-3.4A)NoneCUO A9002 (-3.3A) | 1.45A | 5z0kA-4bedA:20.45z0kB-4bedA:undetectable | 5z0kA-4bedA:5.495z0kB-4bedA:4.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bed | HEMOCYANIN KLH1 (Megathuracrenulata) |
PF00264(Tyrosinase)PF14830(Haemocyan_bet_s) | 5 | HIS A 876HIS A 896HIS A1015ASN A1016HIS A1019 | CUO A9003 (-3.3A)CUO A9003 (-3.4A)CUO A9003 (-3.1A)NoneCUO A9003 (-3.4A) | 1.04A | 5z0kA-4bedA:20.45z0kB-4bedA:undetectable | 5z0kA-4bedA:5.495z0kB-4bedA:4.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bed | HEMOCYANIN KLH1 (Megathuracrenulata) |
PF00264(Tyrosinase)PF14830(Haemocyan_bet_s) | 5 | HIS B1705HIS B1725HIS B1847ASN B1848HIS B1851 | CUO B9005 (-3.2A)CUO B9005 (-3.1A)CUO B9005 (-3.2A)NoneCUO B9005 (-3.2A) | 0.84A | 5z0kA-4bedB:23.05z0kB-4bedB:undetectable | 5z0kA-4bedB:4.445z0kB-4bedB:4.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bed | HEMOCYANIN KLH1 (Megathuracrenulata) |
PF00264(Tyrosinase)PF14830(Haemocyan_bet_s) | 5 | HIS B2122HIS B2141HIS B2260ASN B2261HIS B2264 | CUO B9006 (-3.2A)CUO B9006 (-3.1A)CUO B9006 (-3.2A)NoneCUO B9006 (-3.2A) | 0.92A | 5z0kA-4bedB:23.05z0kB-4bedB:undetectable | 5z0kA-4bedB:4.445z0kB-4bedB:4.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bed | HEMOCYANIN KLH1 (Megathuracrenulata) |
PF00264(Tyrosinase)PF14830(Haemocyan_bet_s) | 5 | HIS B2946HIS B2965HIS B3075HIS B3079SER B3096 | CUO B9008 (-3.1A)CUO B9008 (-3.2A)CUO B9008 (-2.8A)CUO B9008 (-3.5A)CUO B9008 ( 4.7A) | 0.73A | 5z0kA-4bedB:23.05z0kB-4bedB:undetectable | 5z0kA-4bedB:4.445z0kB-4bedB:4.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bed | HEMOCYANIN KLH1 (Megathuracrenulata) |
PF00264(Tyrosinase)PF14830(Haemocyan_bet_s) | 5 | HIS B2946HIS B3075ASN B3076HIS B3079SER B3096 | CUO B9008 (-3.1A)CUO B9008 (-2.8A)NoneCUO B9008 (-3.5A)CUO B9008 ( 4.7A) | 0.47A | 5z0kA-4bedB:23.05z0kB-4bedB:undetectable | 5z0kA-4bedB:4.445z0kB-4bedB:4.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f9u | CG32412 (Drosophilamelanogaster) |
PF04389(Peptidase_M28) | 5 | HIS A 114HIS A 297VAL A 295SER A 132PRO A 299 | None ZN A 401 ( 3.1A)NoneNoneNone | 1.49A | 5z0kA-4f9uA:undetectable5z0kB-4f9uA:undetectable | 5z0kA-4f9uA:14.475z0kB-4f9uA:13.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fbq | DNA REPAIR ANDTELOMERE MAINTENANCEPROTEIN NBS1,DNAREPAIR PROTEIN RAD32CHIMERIC PROTEIN (Schizosaccharomycespombe) |
PF00149(Metallophos)PF04152(Mre11_DNA_bind) | 5 | HIS A1027HIS A1252HIS A1250HIS A1222VAL A1221 | MN A1502 (-3.5A) MN A1502 (-3.7A) MN A1501 (-3.3A) MN A1501 (-3.6A)None | 1.08A | 5z0kA-4fbqA:undetectable5z0kB-4fbqA:undetectable | 5z0kA-4fbqA:10.025z0kB-4fbqA:10.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j3q | CATECHOL OXIDASE (Aspergillusoryzae) |
PF00264(Tyrosinase) | 5 | HIS A 102HIS A 110HIS A 284HIS A 288SER A 302 | CU A1001 (-3.2A) CU A1001 (-3.3A) CU A1002 (-3.2A) CU A1002 (-3.2A) CU A1001 ( 4.9A) | 0.61A | 5z0kA-4j3qA:27.65z0kB-4j3qA:undetectable | 5z0kA-4j3qA:27.695z0kB-4j3qA:15.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j3q | CATECHOL OXIDASE (Aspergillusoryzae) |
PF00264(Tyrosinase) | 5 | HIS A 102HIS A 110HIS A 312HIS A 288SER A 302 | CU A1001 (-3.2A) CU A1001 (-3.3A) CU A1002 (-3.2A) CU A1002 (-3.2A) CU A1001 ( 4.9A) | 1.44A | 5z0kA-4j3qA:27.65z0kB-4j3qA:undetectable | 5z0kA-4j3qA:27.695z0kB-4j3qA:15.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j3q | CATECHOL OXIDASE (Aspergillusoryzae) |
PF00264(Tyrosinase) | 5 | HIS A 110HIS A 102HIS A 288HIS A 284ASP A 316 | CU A1001 (-3.3A) CU A1001 (-3.2A) CU A1002 (-3.2A) CU A1002 (-3.2A)None | 1.44A | 5z0kA-4j3qA:27.65z0kB-4j3qA:undetectable | 5z0kA-4j3qA:27.695z0kB-4j3qA:15.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j3q | CATECHOL OXIDASE (Aspergillusoryzae) |
PF00264(Tyrosinase) | 5 | HIS A 110HIS A 119HIS A 288HIS A 284VAL A 283 | CU A1001 (-3.3A) CU A1001 (-3.2A) CU A1002 (-3.2A) CU A1002 (-3.2A)None | 1.46A | 5z0kA-4j3qA:27.65z0kB-4j3qA:undetectable | 5z0kA-4j3qA:27.695z0kB-4j3qA:15.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j3q | CATECHOL OXIDASE (Aspergillusoryzae) |
PF00264(Tyrosinase) | 5 | HIS A 288HIS A 284HIS A 110HIS A 102SER A 302 | CU A1002 (-3.2A) CU A1002 (-3.2A) CU A1001 (-3.3A) CU A1001 (-3.2A) CU A1001 ( 4.9A) | 1.28A | 5z0kA-4j3qA:27.65z0kB-4j3qA:undetectable | 5z0kA-4j3qA:27.695z0kB-4j3qA:15.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k3j | HEPATOCYTE GROWTHFACTOR BETA CHAIN (Homo sapiens) |
PF01403(Sema)PF01437(PSI) | 5 | HIS B 144ILE B 70VAL B 136SER B 132PRO B 88 | None | 1.39A | 5z0kA-4k3jB:undetectable5z0kB-4k3jB:undetectable | 5z0kA-4k3jB:10.295z0kB-4k3jB:9.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qma | CYSTEINE DIOXYGENASETYPE I (Cupriaviduspinatubonensis) |
PF05995(CDO_I) | 5 | HIS A 147HIS A 96HIS A 162VAL A 136SER A 111 | FE A 301 (-3.3A) FE A 301 ( 3.3A)NoneNoneNone | 1.30A | 5z0kA-4qmaA:undetectable5z0kB-4qmaA:undetectable | 5z0kA-4qmaA:19.325z0kB-4qmaA:19.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yzw | AGAP004976-PA (Anophelesgambiae) |
PF00372(Hemocyanin_M)PF03722(Hemocyanin_N)PF03723(Hemocyanin_C) | 7 | HIS A 223HIS A 227HIS A 379ASN A 380HIS A 383VAL A 384PRO A 101 | CU A 801 (-3.0A) CU A 801 (-3.2A) CU A 802 (-3.2A)None CU A 802 (-3.2A)NoneNone | 0.79A | 5z0kA-4yzwA:8.85z0kB-4yzwA:undetectable | 5z0kA-4yzwA:7.505z0kB-4yzwA:8.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zo3 | ACYLHOMOSERINELACTONASE (Chryseobacteriumsp. StRB126) |
PF00753(Lactamase_B) | 5 | HIS A 305HIS A 145VAL A 243SER A 304PRO A 235 | ZN A 402 ( 3.3A) ZN A 401 (-3.3A)None ZN A 402 ( 4.7A)None | 1.49A | 5z0kA-4zo3A:undetectable5z0kB-4zo3A:undetectable | 5z0kA-4zo3A:16.515z0kB-4zo3A:13.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ce9 | POLYPHENOL OXIDASE (Juglans regia) |
PF00264(Tyrosinase)PF12142(PPO1_DWL) | 5 | HIS A 87HIS A 108HIS A 239ASN A 240HIS A 243 | CU A 402 ( 3.2A) CU A 402 ( 3.2A) CU A 401 ( 3.2A)None CU A 401 ( 3.2A) | 0.29A | 5z0kA-5ce9A:20.95z0kB-5ce9A:undetectable | 5z0kA-5ce9A:14.905z0kB-5ce9A:14.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ce9 | POLYPHENOL OXIDASE (Juglans regia) |
PF00264(Tyrosinase)PF12142(PPO1_DWL) | 5 | HIS A 108HIS A 87HIS A 243HIS A 239ASP A 277 | CU A 402 ( 3.2A) CU A 402 ( 3.2A) CU A 401 ( 3.2A) CU A 401 ( 3.2A)None | 1.50A | 5z0kA-5ce9A:20.95z0kB-5ce9A:undetectable | 5z0kA-5ce9A:14.905z0kB-5ce9A:14.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ce9 | POLYPHENOL OXIDASE (Juglans regia) |
PF00264(Tyrosinase)PF12142(PPO1_DWL) | 5 | HIS A 239HIS A 243HIS A 87HIS A 108PRO A 17 | CU A 401 ( 3.2A) CU A 401 ( 3.2A) CU A 402 ( 3.2A) CU A 402 ( 3.2A)None | 1.12A | 5z0kA-5ce9A:20.95z0kB-5ce9A:undetectable | 5z0kA-5ce9A:14.905z0kB-5ce9A:14.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ebb | ACIDSPHINGOMYELINASE-LIKE PHOSPHODIESTERASE3A (Homo sapiens) |
PF00149(Metallophos) | 5 | HIS A 295HIS A 152HIS A 114VAL A 115PRO A 50 | ZN A 702 ( 3.4A)MLI A 706 (-3.9A)MLI A 706 (-3.9A)NoneNAG A 704 ( 4.7A) | 1.37A | 5z0kA-5ebbA:undetectable5z0kB-5ebbA:undetectable | 5z0kA-5ebbA:15.735z0kB-5ebbA:11.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fca | ACIDSPHINGOMYELINASE-LIKE PHOSPHODIESTERASE3A (Mus musculus) |
PF00149(Metallophos) | 5 | HIS A 292HIS A 149HIS A 111VAL A 112PRO A 47 | ZN A 501 (-3.4A) ZN A 503 (-3.8A)GOL A 518 (-2.7A)NoneNAG A 508 ( 4.9A) | 1.34A | 5z0kA-5fcaA:undetectable5z0kB-5fcaA:undetectable | 5z0kA-5fcaA:15.345z0kB-5fcaA:11.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fnp | IRON-SULFUR CLUSTERREPAIR PROTEIN YTFE (Escherichiacoli) |
PF01814(Hemerythrin)PF04405(ScdA_N) | 5 | HIS A 204ILE A 79HIS A 84HIS A 129HIS A 160 | ZN A1222 ( 3.3A) ZN A1222 ( 4.9A) ZN A1222 ( 3.3A) ZN A1221 ( 3.2A) ZN A1221 (-3.3A) | 1.31A | 5z0kA-5fnpA:undetectable5z0kB-5fnpA:undetectable | 5z0kA-5fnpA:20.755z0kB-5fnpA:18.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i3a | TYROSINASE (Bacillusmegaterium) |
PF00264(Tyrosinase) | 5 | HIS A 42HIS A 60HIS A 204ASN A 205HIS A 208 | ZN A 301 ( 3.2A) ZN A 301 ( 3.2A) ZN A 302 ( 3.4A)HQE A 303 (-3.4A)HQE A 303 ( 3.0A) | 0.35A | 5z0kA-5i3aA:39.55z0kB-5i3aA:undetectable | 5z0kA-5i3aA:22.405z0kB-5i3aA:14.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i3a | TYROSINASE (Bacillusmegaterium) |
PF00264(Tyrosinase) | 5 | HIS A 60HIS A 42HIS A 208HIS A 204ASP A 235 | ZN A 301 ( 3.2A) ZN A 301 ( 3.2A)HQE A 303 ( 3.0A) ZN A 302 ( 3.4A)None | 1.47A | 5z0kA-5i3aA:39.55z0kB-5i3aA:undetectable | 5z0kA-5i3aA:22.405z0kB-5i3aA:14.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kar | ACIDSPHINGOMYELINASE-LIKE PHOSPHODIESTERASE3B (Mus musculus) |
PF00149(Metallophos) | 5 | HIS A 279HIS A 135HIS A 97VAL A 98PRO A 33 | GOL A 515 ( 2.6A)NoneNoneNAG A 511 ( 4.0A)NAG A 511 ( 3.7A) | 1.38A | 5z0kA-5karA:undetectable5z0kB-5karA:undetectable | 5z0kA-5karA:12.975z0kB-5karA:17.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m8t | 5,6-DIHYDROXYINDOLE-2-CARBOXYLIC ACIDOXIDASE (Homo sapiens) |
PF00264(Tyrosinase) | 6 | HIS A 192HIS A 215HIS A 377ASN A 378HIS A 381SER A 394 | ZN A 512 ( 3.3A) ZN A 512 ( 3.3A) ZN A 511 ( 3.2A)0TR A 513 ( 4.4A) ZN A 511 ( 3.3A)0TR A 513 (-3.2A) | 0.33A | 5z0kA-5m8tA:28.65z0kB-5m8tA:undetectable | 5z0kA-5m8tA:9.425z0kB-5m8tA:11.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m8t | 5,6-DIHYDROXYINDOLE-2-CARBOXYLIC ACIDOXIDASE (Homo sapiens) |
PF00264(Tyrosinase) | 6 | HIS A 192HIS A 224HIS A 377ASN A 378HIS A 381SER A 394 | ZN A 512 ( 3.3A) ZN A 512 (-3.5A) ZN A 511 ( 3.2A)0TR A 513 ( 4.4A) ZN A 511 ( 3.3A)0TR A 513 (-3.2A) | 1.44A | 5z0kA-5m8tA:28.65z0kB-5m8tA:undetectable | 5z0kA-5m8tA:9.425z0kB-5m8tA:11.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m8t | 5,6-DIHYDROXYINDOLE-2-CARBOXYLIC ACIDOXIDASE (Homo sapiens) |
PF00264(Tyrosinase) | 5 | HIS A 215HIS A 192HIS A 381HIS A 377ASP A 408 | ZN A 512 ( 3.3A) ZN A 512 ( 3.3A) ZN A 511 ( 3.3A) ZN A 511 ( 3.2A)None | 1.45A | 5z0kA-5m8tA:28.65z0kB-5m8tA:undetectable | 5z0kA-5m8tA:9.425z0kB-5m8tA:11.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m8t | 5,6-DIHYDROXYINDOLE-2-CARBOXYLIC ACIDOXIDASE (Homo sapiens) |
PF00264(Tyrosinase) | 5 | HIS A 381HIS A 377HIS A 215HIS A 192SER A 394 | ZN A 511 ( 3.3A) ZN A 511 ( 3.2A) ZN A 512 ( 3.3A) ZN A 512 ( 3.3A)0TR A 513 (-3.2A) | 1.11A | 5z0kA-5m8tA:28.65z0kB-5m8tA:undetectable | 5z0kA-5m8tA:9.425z0kB-5m8tA:11.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m8t | 5,6-DIHYDROXYINDOLE-2-CARBOXYLIC ACIDOXIDASE (Homo sapiens) |
PF00264(Tyrosinase) | 5 | HIS A 381HIS A 377HIS A 224HIS A 192SER A 394 | ZN A 511 ( 3.3A) ZN A 511 ( 3.2A) ZN A 512 (-3.5A) ZN A 512 ( 3.3A)0TR A 513 (-3.2A) | 1.46A | 5z0kA-5m8tA:28.65z0kB-5m8tA:undetectable | 5z0kA-5m8tA:9.425z0kB-5m8tA:11.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m8t | 5,6-DIHYDROXYINDOLE-2-CARBOXYLIC ACIDOXIDASE (Homo sapiens) |
PF00264(Tyrosinase) | 5 | HIS A 381HIS A 404HIS A 215HIS A 192SER A 394 | ZN A 511 ( 3.3A) ZN A 511 (-3.1A) ZN A 512 ( 3.3A) ZN A 512 ( 3.3A)0TR A 513 (-3.2A) | 1.47A | 5z0kA-5m8tA:28.65z0kB-5m8tA:undetectable | 5z0kA-5m8tA:9.425z0kB-5m8tA:11.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mtz | RIBONUCLEASE Z (Saccharomycescerevisiae) |
PF13691(Lactamase_B_4) | 5 | HIS A 545HIS A 759HIS A 670SER A 539PRO A 702 | ZN A 902 (-3.4A) ZN A 902 ( 3.2A) ZN A 901 ( 3.5A)NoneNone | 1.33A | 5z0kA-5mtzA:undetectable5z0kB-5mtzA:undetectable | 5z0kA-5mtzA:6.515z0kB-5mtzA:5.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nqd | ARSENITE OXIDASELARGE SUBUNIT AIOA[3FE-4S] CLUSTER,MO-MOLYBDOPTERINCOFACTOR-BINDINGACTIVE SITE (Rhizobium sp.NT-26) |
no annotation | 5 | HIS A 489ILE A 550HIS A 482VAL A 481SER A 166 | None | 1.45A | 5z0kA-5nqdA:undetectable5z0kB-5nqdA:undetectable | 5z0kA-5nqdA:13.585z0kB-5nqdA:19.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5or4 | CATECHOL OXIDASE (Aspergillusoryzae) |
no annotation | 5 | HIS A 102HIS A 110HIS A 284HIS A 288SER A 302 | CU A2001 (-3.3A) CU A2001 (-3.3A) CU A2002 (-3.2A) CU A2002 (-3.2A)None | 0.61A | 5z0kA-5or4A:26.75z0kB-5or4A:undetectable | 5z0kA-5or4A:16.255z0kB-5or4A:25.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5or4 | CATECHOL OXIDASE (Aspergillusoryzae) |
no annotation | 5 | HIS A 110HIS A 119HIS A 288HIS A 284VAL A 283 | CU A2001 (-3.3A) CU A2001 (-3.3A) CU A2002 (-3.2A) CU A2002 (-3.2A)None | 1.45A | 5z0kA-5or4A:26.75z0kB-5or4A:undetectable | 5z0kA-5or4A:16.255z0kB-5or4A:25.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6eys | - (-) |
no annotation | 5 | HIS B 216HIS B 220HIS B 375HIS B 379SER B 422 | None | 0.77A | 5z0kA-6eysB:8.45z0kB-6eysB:0.5 | 5z0kA-6eysB:undetectable5z0kB-6eysB:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6eys | - (-) |
no annotation | 5 | HIS B 379HIS B 375HIS B 220HIS B 216SER B 422 | None | 1.18A | 5z0kA-6eysB:8.45z0kB-6eysB:0.5 | 5z0kA-6eysB:undetectable5z0kB-6eysB:undetectable |