SIMILAR PATTERNS OF AMINO ACIDS FOR 5YW0_A_ACTA412_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cew | CYSTATIN (Gallus gallus) |
PF00031(Cystatin) | 3 | LYS I 73ASN I 33SER I 42 | None | 1.18A | 5yw0A-1cewI:1.1 | 5yw0A-1cewI:16.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cy9 | DNA TOPOISOMERASE I (Escherichiacoli) |
PF01131(Topoisom_bac) | 3 | LYS A 365ASN A 326SER A 357 | None | 1.13A | 5yw0A-1cy9A:0.0 | 5yw0A-1cy9A:24.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ems | NIT-FRAGILEHISTIDINE TRIADFUSION PROTEIN (Caenorhabditiselegans) |
PF00795(CN_hydrolase)PF01230(HIT) | 3 | LYS A 127ASN A 110SER A 147 | EMC A 451 (-3.0A)EMC A 453 (-3.2A)EMC A 453 (-3.4A) | 1.26A | 5yw0A-1emsA:0.0 | 5yw0A-1emsA:22.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1exs | BETA-LACTOGLOBULIN (Sus scrofa) |
PF00061(Lipocalin) | 3 | LYS A 83ASN A 90SER A 110 | None | 1.08A | 5yw0A-1exsA:0.0 | 5yw0A-1exsA:21.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f76 | DIHYDROOROTATEDEHYDROGENASE(QUINONE) (Escherichiacoli) |
PF01180(DHO_dh) | 3 | LYS A 217ASN A 172SER A 175 | FMN A1337 (-2.8A)ORO A1338 ( 3.2A)ORO A1338 (-3.0A) | 1.25A | 5yw0A-1f76A:0.0 | 5yw0A-1f76A:22.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f7u | ARGINYL-TRNASYNTHETASE (Saccharomycescerevisiae) |
PF00750(tRNA-synt_1d)PF03485(Arg_tRNA_synt_N)PF05746(DALR_1) | 3 | LYS A 2ASN A 6SER A 9 | None | 1.11A | 5yw0A-1f7uA:0.0 | 5yw0A-1f7uA:20.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i74 | PROBABLEMANGANESE-DEPENDENTINORGANICPYROPHOSPHATASE (Streptococcusmutans) |
PF01368(DHH)PF02833(DHHA2) | 3 | LYS A 273ASN A 270SER A 212 | None | 0.94A | 5yw0A-1i74A:0.0 | 5yw0A-1i74A:23.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jal | YCHF PROTEIN (Haemophilusinfluenzae) |
PF01926(MMR_HSR1)PF06071(YchF-GTPase_C) | 3 | LYS A 24ASN A 20SER A 242 | None | 1.20A | 5yw0A-1jalA:0.0 | 5yw0A-1jalA:21.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lkj | CALMODULIN (Saccharomycescerevisiae) |
PF13499(EF-hand_7) | 3 | LYS A 77ASN A 79SER A 2 | None | 0.98A | 5yw0A-1lkjA:undetectable | 5yw0A-1lkjA:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nr6 | CYTOCHROME P450 2C5 (Oryctolaguscuniculus) |
PF00067(p450) | 3 | LYS A 72ASN A 218SER A 99 | None | 1.27A | 5yw0A-1nr6A:0.0 | 5yw0A-1nr6A:23.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pk0 | CALMODULIN-SENSITIVEADENYLATE CYCLASE (Bacillusanthracis) |
PF03497(Anthrax_toxA) | 3 | LYS A 404ASN A 451SER A 447 | None | 1.10A | 5yw0A-1pk0A:undetectable | 5yw0A-1pk0A:20.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rtg | HUMAN GELATINASE A (Homo sapiens) |
PF00045(Hemopexin) | 3 | LYS A 576ASN A 642SER A 629 | None | 1.19A | 5yw0A-1rtgA:undetectable | 5yw0A-1rtgA:20.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v72 | ALDOLASE (Pseudomonasputida) |
PF01212(Beta_elim_lyase) | 3 | LYS A 268ASN A 265SER A 21 | None | 1.25A | 5yw0A-1v72A:undetectable | 5yw0A-1v72A:20.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vpl | ABC TRANSPORTER,ATP-BINDING PROTEIN (Thermotogamaritima) |
PF00005(ABC_tran) | 3 | LYS A 142ASN A 169SER A 136 | None | 1.25A | 5yw0A-1vplA:undetectable | 5yw0A-1vplA:24.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wyp | CALPONIN 1 (Homo sapiens) |
PF00307(CH) | 3 | LYS A 9ASN A 8SER A 5 | None | 1.27A | 5yw0A-1wypA:undetectable | 5yw0A-1wypA:17.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wz9 | MASPIN PRECURSOR (Homo sapiens) |
PF00079(Serpin) | 3 | LYS A 371ASN A 27SER A 374 | CME A 20 ( 3.8A)CME A 373 (-3.7A)CME A 373 ( 3.5A) | 1.15A | 5yw0A-1wz9A:undetectable | 5yw0A-1wz9A:22.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2abq | FRUCTOSE 1-PHOSPHATEKINASE (Bacillushalodurans) |
PF00294(PfkB) | 3 | LYS A 92ASN A 90SER A 10 | None | 1.25A | 5yw0A-2abqA:undetectable | 5yw0A-2abqA:23.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b3q | GREEN FLUORESCENTPROTEIN (Aequoreavictoria) |
PF01353(GFP) | 3 | LYS A 140ASN A 135SER A 175 | None MG A 701 (-3.4A) MG A 701 ( 4.7A) | 1.26A | 5yw0A-2b3qA:undetectable | 5yw0A-2b3qA:25.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d0v | METHANOLDEHYDROGENASE LARGESUBUNIT (Hyphomicrobiumdenitrificans) |
PF01011(PQQ)PF13360(PQQ_2) | 3 | LYS A 126ASN A 73SER A 69 | None | 1.01A | 5yw0A-2d0vA:undetectable | 5yw0A-2d0vA:18.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gti | REPLICASEPOLYPROTEIN 1AB (Murinecoronavirus) |
PF06471(NSP11) | 3 | LYS A 353ASN A 74SER A 302 | None | 1.24A | 5yw0A-2gtiA:undetectable | 5yw0A-2gtiA:24.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2khg | PLNJ (Lactobacillusplantarum) |
no annotation | 3 | LYS A 4ASN A 5SER A 9 | None | 1.21A | 5yw0A-2khgA:undetectable | 5yw0A-2khgA:16.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2l02 | UNCHARACTERIZEDPROTEIN (Bacteroidesthetaiotaomicron) |
PF10771(DUF2582) | 3 | LYS A 12ASN A 9SER A 38 | None | 0.72A | 5yw0A-2l02A:undetectable | 5yw0A-2l02A:15.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2mzv | CYSTATIN (Sesamum indicum) |
PF16845(SQAPI) | 3 | LYS A 192ASN A 190SER A 158 | None | 0.93A | 5yw0A-2mzvA:undetectable | 5yw0A-2mzvA:19.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nvv | ACETYL-COAHYDROLASE/TRANSFERASE FAMILY PROTEIN (Porphyromonasgingivalis) |
PF02550(AcetylCoA_hydro)PF13336(AcetylCoA_hyd_C) | 3 | LYS A 33ASN A 31SER A 24 | LYS A 33 ( 0.0A)ASN A 31 ( 0.6A)SER A 24 ( 0.0A) | 1.17A | 5yw0A-2nvvA:undetectable | 5yw0A-2nvvA:21.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qqk | NEUROPILIN-2 (Homo sapiens) |
PF00431(CUB)PF00754(F5_F8_type_C) | 3 | LYS A 67ASN A 65SER A 146 | None | 1.00A | 5yw0A-2qqkA:undetectable | 5yw0A-2qqkA:21.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qy1 | PECTATE LYASE II (Xanthomonascampestris) |
PF00544(Pec_lyase_C) | 3 | LYS A 92ASN A 93SER A 146 | None | 1.23A | 5yw0A-2qy1A:undetectable | 5yw0A-2qy1A:19.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qza | SECRETED EFFECTORPROTEIN (Salmonellaenterica) |
PF13599(Pentapeptide_4)PF13979(SopA_C)PF13981(SopA) | 3 | LYS A 354ASN A 352SER A 699 | None | 1.25A | 5yw0A-2qzaA:undetectable | 5yw0A-2qzaA:20.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xka | FTSZ/TUBULIN-RELATEDPROTEIN (Bacillusthuringiensis) |
PF00091(Tubulin) | 3 | LYS A 335ASN A 262SER A 260 | None | 1.29A | 5yw0A-2xkaA:undetectable | 5yw0A-2xkaA:21.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zvs | UNCHARACTERIZEDFERREDOXIN-LIKEPROTEIN YFHL (Escherichiacoli) |
PF00037(Fer4) | 3 | LYS A 36ASN A 33SER A 24 | None | 1.06A | 5yw0A-2zvsA:undetectable | 5yw0A-2zvsA:11.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3agr | NUCLEOSIDETRIPHOSPHATEHYDROLASE (Neosporacaninum) |
PF01150(GDA1_CD39) | 3 | LYS A 364ASN A 363SER A 342 | None | 1.29A | 5yw0A-3agrA:undetectable | 5yw0A-3agrA:18.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cfx | UPF0100 PROTEINMA_0280 (Methanosarcinaacetivorans) |
PF13531(SBP_bac_11) | 3 | LYS A 276ASN A 273SER A 176 | None | 0.99A | 5yw0A-3cfxA:undetectable | 5yw0A-3cfxA:22.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3csk | PROBABLEDIPEPTIDYL-PEPTIDASE3 (Saccharomycescerevisiae) |
PF03571(Peptidase_M49) | 3 | LYS A 108ASN A 100SER A 52 | None | 1.07A | 5yw0A-3cskA:undetectable | 5yw0A-3cskA:19.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dla | GLUTAMINE-DEPENDENTNAD(+) SYNTHETASE (Mycobacteriumtuberculosis) |
PF00795(CN_hydrolase)PF02540(NAD_synthase) | 3 | LYS A 414ASN A 411SER A 536 | None | 1.14A | 5yw0A-3dlaA:undetectable | 5yw0A-3dlaA:17.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ho6 | TOXIN A (Clostridioidesdifficile) |
PF11713(Peptidase_C80) | 3 | LYS A 35ASN A 61SER A 65 | IHP A 270 ( 3.3A)NoneNone | 1.07A | 5yw0A-3ho6A:undetectable | 5yw0A-3ho6A:20.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i6r | DIHYDROOROTATEDEHYDROGENASEHOMOLOG,MITOCHONDRIAL (Plasmodiumfalciparum) |
PF01180(DHO_dh) | 3 | LYS A 429ASN A 342SER A 345 | FMN A1002 (-2.8A)ORO A1003 ( 3.5A)ORO A1003 (-3.2A) | 1.24A | 5yw0A-3i6rA:undetectable | 5yw0A-3i6rA:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iwf | TRANSCRIPTIONREGULATOR RPIRFAMILY (Staphylococcusepidermidis) |
PF01418(HTH_6) | 3 | LYS A 21ASN A 18SER A 51 | None | 1.05A | 5yw0A-3iwfA:undetectable | 5yw0A-3iwfA:17.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k6x | SOLUTE-BINDINGPROTEIN MA_0280 (Methanosarcinaacetivorans) |
PF13531(SBP_bac_11) | 3 | LYS A 276ASN A 273SER A 176 | None | 1.02A | 5yw0A-3k6xA:undetectable | 5yw0A-3k6xA:22.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lhc | CYANOVIRIN-N (Nostocellipsosporum) |
PF08881(CVNH) | 3 | LYS A 83ASN A 85SER A 66 | None | 1.27A | 5yw0A-3lhcA:undetectable | 5yw0A-3lhcA:15.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ns5 | EUKARYOTICTRANSLATIONINITIATION FACTOR 3SUBUNIT B (Saccharomycescerevisiae) |
PF00076(RRM_1) | 3 | LYS A 139ASN A 135SER A 133 | None | 1.15A | 5yw0A-3ns5A:undetectable | 5yw0A-3ns5A:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ppl | ASPARTATEAMINOTRANSFERASE (Corynebacteriumglutamicum) |
PF12897(Aminotran_MocR) | 3 | LYS A 391ASN A 392SER A 353 | None | 1.10A | 5yw0A-3pplA:undetectable | 5yw0A-3pplA:22.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3srz | TOXIN A (Clostridioidesdifficile) |
PF12918(TcdB_N)PF12919(TcdA_TcdB) | 3 | LYS A 44ASN A 41SER A 88 | None | 1.27A | 5yw0A-3srzA:undetectable | 5yw0A-3srzA:22.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vnf | MEMBRANE-ASSOCIATEDPROTEIN VP24 (Sudanebolavirus) |
PF06389(Filo_VP24) | 3 | LYS A 52ASN A 50SER A 225 | None | 1.17A | 5yw0A-3vnfA:undetectable | 5yw0A-3vnfA:22.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vse | PUTATIVEUNCHARACTERIZEDPROTEIN (Staphylococcusaureus) |
PF10672(Methyltrans_SAM) | 3 | LYS A 382ASN A 333SER A 296 | None | 1.15A | 5yw0A-3vseA:undetectable | 5yw0A-3vseA:25.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w77 | FMN-DEPENDENTNADH-AZOREDUCTASE (Bacillus sp.B29) |
PF02525(Flavodoxin_2) | 3 | LYS A 8ASN A 10SER A 19 | NoneFMN A 301 (-3.4A)FMN A 301 (-2.6A) | 1.22A | 5yw0A-3w77A:undetectable | 5yw0A-3w77A:20.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aca | TRANSLATIONELONGATION FACTORSELB (Methanococcusmaripaludis) |
PF00009(GTP_EFTU)PF03144(GTP_EFTU_D2) | 3 | LYS A 187ASN A 208SER A 78 | None | 1.25A | 5yw0A-4acaA:undetectable | 5yw0A-4acaA:20.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bqi | ALPHA-GLUCANPHOSPHORYLASE 2,CYTOSOLIC (Arabidopsisthaliana) |
PF00343(Phosphorylase) | 3 | LYS A 542ASN A 545SER A 499 | None | 1.16A | 5yw0A-4bqiA:undetectable | 5yw0A-4bqiA:15.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4btg | MAJOR INNER PROTEINP1 (Pseudomonasvirus phi6) |
no annotation | 3 | LYS A 58ASN A 60SER A 159 | None | 1.29A | 5yw0A-4btgA:undetectable | 5yw0A-4btgA:17.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c41 | CORTICOSTEROID-BINDING GLOBULIN (Homo sapiens) |
PF00079(Serpin) | 3 | LYS A 319ASN A 347SER A 169 | None | 1.30A | 5yw0A-4c41A:undetectable | 5yw0A-4c41A:20.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cgn | GLYCYLPEPTIDEN-TETRADECANOYLTRANSFERASE (Leishmaniamajor) |
PF01233(NMT)PF02799(NMT_C) | 3 | LYS A 318ASN A 315SER A 353 | None | 1.15A | 5yw0A-4cgnA:undetectable | 5yw0A-4cgnA:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4eq9 | ABC TRANSPORTERSUBSTRATE-BINDINGPROTEIN-AMINO ACIDTRANSPORT (Streptococcuspneumoniae) |
PF00497(SBP_bac_3) | 3 | LYS A 83ASN A 45SER A 47 | NoneGSH A 301 (-3.3A)None | 1.28A | 5yw0A-4eq9A:undetectable | 5yw0A-4eq9A:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f3e | CASA (Thermusthermophilus) |
PF09481(CRISPR_Cse1) | 3 | LYS A 376ASN A 373SER A 449 | None | 1.28A | 5yw0A-4f3eA:undetectable | 5yw0A-4f3eA:21.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hjc | ENVELOPEGLYCOPROTEIN (Rift Valleyfeverphlebovirus) |
PF07245(Phlebovirus_G2) | 3 | LYS A 988ASN A 986SER A 898 | None | 1.29A | 5yw0A-4hjcA:undetectable | 5yw0A-4hjcA:19.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ifd | EXOSOME COMPLEXCOMPONENT RRP43 (Saccharomycescerevisiae) |
PF01138(RNase_PH) | 3 | LYS C 358ASN C 356SER C 354 | None | 1.09A | 5yw0A-4ifdC:undetectable | 5yw0A-4ifdC:21.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4je5 | AROMATIC/AMINOADIPATE AMINOTRANSFERASE 1 (Saccharomycescerevisiae) |
PF00155(Aminotran_1_2) | 3 | LYS A 231ASN A 286SER A 290 | None | 0.83A | 5yw0A-4je5A:undetectable | 5yw0A-4je5A:23.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jrb | GREEN FLUORESCENTPROTEIN (Aequoreavictoria;Blattellagermanica) |
PF01353(GFP)PF06757(Ins_allergen_rp) | 3 | LYS A 140ASN A 135SER A 175 | None | 1.26A | 5yw0A-4jrbA:undetectable | 5yw0A-4jrbA:20.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k1o | CATENIN ALPHA-2 (Mus musculus) |
PF01044(Vinculin) | 3 | LYS A 746ASN A 790SER A 793 | None | 1.28A | 5yw0A-4k1oA:undetectable | 5yw0A-4k1oA:22.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kf5 | FLUORESCENT PROTEINGFP1-9 (syntheticconstruct) |
PF01353(GFP) | 3 | LYS A 140ASN A 135SER A 175 | None | 1.20A | 5yw0A-4kf5A:undetectable | 5yw0A-4kf5A:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lg9 | F-BOX-LIKE/WDREPEAT-CONTAININGPROTEIN TBL1XR1 (Homo sapiens) |
PF00400(WD40) | 3 | LYS A 335ASN A 320SER A 318 | UNX A 605 ( 4.6A)UNX A 613 ( 4.5A)UNX A 605 ( 3.3A) | 1.22A | 5yw0A-4lg9A:undetectable | 5yw0A-4lg9A:19.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4maf | ATP SULFURYLASE (Glycine max) |
PF01747(ATP-sulfurylase)PF14306(PUA_2) | 3 | LYS A 335ASN A 128SER A 130 | None | 1.25A | 5yw0A-4mafA:undetectable | 5yw0A-4mafA:22.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ph9 | PROSTAGLANDIN G/HSYNTHASE 2 (Mus musculus) |
PF00008(EGF)PF03098(An_peroxidase) | 3 | LYS A 469ASN A 465SER A 463 | None | 1.04A | 5yw0A-4ph9A:undetectable | 5yw0A-4ph9A:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pl0 | MICROCIN-J25 EXPORTATP-BINDING/PERMEASEPROTEIN MCJD (Escherichiacoli) |
PF00005(ABC_tran)PF00664(ABC_membrane) | 3 | LYS A 453ASN A 449SER A 447 | None | 0.94A | 5yw0A-4pl0A:undetectable | 5yw0A-4pl0A:19.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r7b | CHOLINE KINASE (Streptococcuspneumoniae) |
PF01633(Choline_kinase) | 3 | LYS A 40ASN A 39SER A 14 | None | 1.06A | 5yw0A-4r7bA:undetectable | 5yw0A-4r7bA:22.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xkq | NICKEL ABCTRANSPORTERSUBSTRATE-BINDINGPROTEIN (Staphylococcusaureus) |
PF00496(SBP_bac_5) | 3 | LYS A 204ASN A 199SER A 14 | None | 1.22A | 5yw0A-4xkqA:undetectable | 5yw0A-4xkqA:21.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xq6 | DIHYDROOROTATEDEHYDROGENASE(QUINONE) (Mycobacteriumtuberculosis) |
PF01180(DHO_dh) | 3 | LYS A 212ASN A 176SER A 179 | FMN A 401 (-2.9A)FMN A 401 (-3.4A)FMN A 401 (-3.6A) | 1.13A | 5yw0A-4xq6A:undetectable | 5yw0A-4xq6A:20.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ysw | XANTHINEDEHYDROGENASE/OXIDASE (Rattusnorvegicus) |
PF00111(Fer2)PF00941(FAD_binding_5)PF01315(Ald_Xan_dh_C)PF01799(Fer2_2)PF02738(Ald_Xan_dh_C2)PF03450(CO_deh_flav_C) | 3 | LYS A 995ASN A 991SER A 544 | None | 1.27A | 5yw0A-4yswA:undetectable | 5yw0A-4yswA:12.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zf4 | GREEN FLUORESCENTPROTEIN (Aequoreavictoria) |
PF01353(GFP) | 3 | LYS A 90ASN A 85SER A 125 | None | 1.18A | 5yw0A-4zf4A:undetectable | 5yw0A-4zf4A:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5az4 | FLAGELLAR HOOKSUBUNIT PROTEIN (Campylobacterjejuni) |
PF07196(Flagellin_IN)PF07559(FlaE) | 3 | LYS A 645ASN A 654SER A 728 | None | 0.81A | 5yw0A-5az4A:undetectable | 5yw0A-5az4A:17.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c2v | HYDRAZINE SYNTHASEALPHA SUBUNIT (CandidatusKueneniastuttgartiensis) |
no annotation | 3 | LYS A 447ASN A 432SER A 234 | None | 1.25A | 5yw0A-5c2vA:undetectable | 5yw0A-5c2vA:17.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c6u | AMINOTRANSFERASE (Mycobacteriumtuberculosis) |
PF12897(Aminotran_MocR) | 3 | LYS A 389ASN A 390SER A 351 | None | 1.11A | 5yw0A-5c6uA:undetectable | 5yw0A-5c6uA:24.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cfc | VP1VP3 (Cardiovirus B;Cardiovirus B) |
no annotationPF00073(Rhv) | 3 | LYS A 1ASN B 160SER A 11 | None | 1.08A | 5yw0A-5cfcA:undetectable | 5yw0A-5cfcA:21.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cfc | VP1VP3 (Cardiovirus B;Cardiovirus B) |
no annotationPF00073(Rhv) | 3 | LYS A 7ASN A 4SER B 158 | None | 1.23A | 5yw0A-5cfcA:undetectable | 5yw0A-5cfcA:21.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cqe | MATRIX PROTEIN 1 (Influenza Avirus) |
PF00598(Flu_M1) | 3 | LYS A 95ASN A 92SER A 120 | None | 1.10A | 5yw0A-5cqeA:undetectable | 5yw0A-5cqeA:21.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e3c | DIPEPTIDYL PEPTIDASE3 (Homo sapiens) |
PF03571(Peptidase_M49) | 3 | LYS A 113ASN A 105SER A 53 | None | 0.91A | 5yw0A-5e3cA:undetectable | 5yw0A-5e3cA:19.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eef | HDAC6 (Danio rerio) |
PF00850(Hist_deacetyl) | 3 | LYS A 288ASN A 287SER A 400 | None | 1.13A | 5yw0A-5eefA:undetectable | 5yw0A-5eefA:22.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g53 | ENGINEERED DOMAIN OFHUMAN G ALPHA S LONGISOFORM (Homo sapiens) |
PF00503(G-alpha) | 3 | LYS C 274ASN C 278SER C 352 | None | 1.24A | 5yw0A-5g53C:undetectable | 5yw0A-5g53C:18.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hde | TYROSINE-PROTEINPHOSPHATASENON-RECEPTOR TYPE 12 (Homo sapiens) |
PF00102(Y_phosphatase) | 3 | LYS A 60ASN A 58SER A 86 | None | 1.23A | 5yw0A-5hdeA:undetectable | 5yw0A-5hdeA:22.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ikr | PROSTAGLANDIN G/HSYNTHASE 2 (Homo sapiens) |
PF00008(EGF)PF03098(An_peroxidase) | 3 | LYS A 468ASN A 464SER A 462 | None | 1.07A | 5yw0A-5ikrA:undetectable | 5yw0A-5ikrA:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ip9 | DNA-DIRECTED RNAPOLYMERASE IISUBUNIT RPB1 (Saccharomycescerevisiae) |
PF00623(RNA_pol_Rpb1_2)PF04983(RNA_pol_Rpb1_3)PF04990(RNA_pol_Rpb1_7)PF04992(RNA_pol_Rpb1_6)PF04997(RNA_pol_Rpb1_1)PF04998(RNA_pol_Rpb1_5)PF05000(RNA_pol_Rpb1_4) | 3 | LYS A 49ASN A 54SER A 249 | None | 1.22A | 5yw0A-5ip9A:undetectable | 5yw0A-5ip9A:9.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jxl | FLAGELLAR HOOKPROTEIN FLGE (Campylobacterjejuni) |
PF00460(Flg_bb_rod)PF06429(Flg_bbr_C)PF07196(Flagellin_IN)PF07559(FlaE) | 3 | LYS A 631ASN A 640SER A 714 | None | 1.28A | 5yw0A-5jxlA:undetectable | 5yw0A-5jxlA:16.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5klf | CARBOHYDRATE BINDINGMODULE E1 (unculturedbacterium) |
no annotation | 3 | LYS A 19ASN A 96SER A 36 | GD A 109 ( 4.7A)NoneNone | 1.28A | 5yw0A-5klfA:undetectable | 5yw0A-5klfA:15.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lx8 | SUSD HOMOLOG (Bacteroidesthetaiotaomicron) |
PF07980(SusD_RagB)PF14322(SusD-like_3) | 3 | LYS A 210ASN A 281SER A 285 | None | 1.29A | 5yw0A-5lx8A:undetectable | 5yw0A-5lx8A:21.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nth | PUTATIVEAMINOPEPTIDASE (Leishmaniamajor) |
PF00883(Peptidase_M17) | 3 | LYS A 320ASN A 318SER A 519 | None | 0.89A | 5yw0A-5nthA:undetectable | 5yw0A-5nthA:18.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o0s | GLUCOSYLCERAMIDASE (Thermoanaerobacteriumxylanolyticum) |
PF04685(DUF608)PF12215(Glyco_hydr_116N)PF17168(DUF5127) | 3 | LYS A 373ASN A 377SER A 244 | None | 1.19A | 5yw0A-5o0sA:undetectable | 5yw0A-5o0sA:16.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o32 | COMPLEMENT FACTOR I (Homo sapiens) |
PF00057(Ldl_recept_a)PF00530(SRCR) | 3 | LYS D 233ASN D 231SER D 251 | None | 1.24A | 5yw0A-5o32D:undetectable | 5yw0A-5o32D:22.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t8y | EPOXYQUEUOSINEREDUCTASE (Bacillussubtilis) |
PF08331(DUF1730)PF13484(Fer4_16)PF13646(HEAT_2) | 3 | LYS A 253ASN A 250SER A 165 | None | 1.25A | 5yw0A-5t8yA:undetectable | 5yw0A-5t8yA:23.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vf6 | SINGLE CHAINVARIABLE FRAGMENT (Gallus gallus) |
no annotation | 3 | LYS A 50ASN A 47SER A 225 | None | 0.98A | 5yw0A-5vf6A:undetectable | 5yw0A-5vf6A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vgz | 26S PROTEASOMEREGULATORY SUBUNIT10B26S PROTEASOMEREGULATORY SUBUNIT6A (Homo sapiens;Homo sapiens) |
no annotationno annotation | 3 | LYS F 79ASN F 76SER E 43 | None | 1.17A | 5yw0A-5vgzF:undetectable | 5yw0A-5vgzF:17.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w0a | GLUCANASE (Trichodermaharzianum) |
no annotation | 3 | LYS A 1ASN A 160SER A 168 | GLN A 1 ( 0.0A)ASN A 160 ( 0.6A)SER A 168 ( 0.0A) | 1.13A | 5yw0A-5w0aA:undetectable | 5yw0A-5w0aA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wg6 | HISTONE-LYSINEN-METHYLTRANSFERASEEZH2,POLYCOMBPROTEIN SUZ12(E.C.2.1.1.43)CHIMERA (Homo sapiens) |
no annotation | 3 | LYS A 261ASN A2607SER A 280 | None | 1.05A | 5yw0A-5wg6A:undetectable | 5yw0A-5wg6A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wln | TYPE II SECRETIONSYSTEM PROTEIN D (Pseudomonasaeruginosa) |
no annotation | 3 | LYS G 359ASN G 361SER G 368 | None | 0.99A | 5yw0A-5wlnG:undetectable | 5yw0A-5wlnG:19.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wmb | DNA REPAIR PROTEINREV1 (Saccharomycescerevisiae) |
no annotation | 3 | LYS A 734ASN A 733SER A 694 | None | 1.29A | 5yw0A-5wmbA:undetectable | 5yw0A-5wmbA:20.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x59 | S PROTEIN (Middle Eastrespiratorysyndrome-relatedcoronavirus) |
PF01601(Corona_S2)PF09408(Spike_rec_bind) | 3 | LYS A 698ASN A 719SER A 684 | None | 1.18A | 5yw0A-5x59A:undetectable | 5yw0A-5x59A:12.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xog | DNA-DIRECTED RNAPOLYMERASE SUBUNIT (Komagataellaphaffii) |
PF00623(RNA_pol_Rpb1_2)PF04983(RNA_pol_Rpb1_3)PF04990(RNA_pol_Rpb1_7)PF04992(RNA_pol_Rpb1_6)PF04997(RNA_pol_Rpb1_1)PF04998(RNA_pol_Rpb1_5)PF05000(RNA_pol_Rpb1_4) | 3 | LYS A 652ASN A 649SER A 556 | None | 1.27A | 5yw0A-5xogA:undetectable | 5yw0A-5xogA:10.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6au6 | GUANINENUCLEOTIDE-BINDINGPROTEIN G(S) SUBUNITALPHA ISOFORMS SHORT (Homo sapiens) |
no annotation | 3 | LYS A 274ASN A 278SER A 352 | None | 1.17A | 5yw0A-6au6A:undetectable | 5yw0A-6au6A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6btm | ALTERNATIVE COMPLEXIII SUBUNIT CALTERNATIVE COMPLEXIII SUBUNIT D (Flavobacteriumjohnsoniae;Flavobacteriumjohnsoniae) |
no annotationno annotation | 3 | LYS D 87ASN C 158SER D 98 | None | 1.25A | 5yw0A-6btmD:undetectable | 5yw0A-6btmD:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c6k | INTERFERON-INDUCEDPROTEIN WITHTETRATRICOPEPTIDEREPEATS 1 (Homo sapiens) |
no annotation | 3 | LYS A 222ASN A 218SER A 250 | None | 0.91A | 5yw0A-6c6kA:undetectable | 5yw0A-6c6kA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6e0s | - (-) |
no annotation | 3 | LYS A 23ASN A 25SER A 63 | None | 1.24A | 5yw0A-6e0sA:undetectable | 5yw0A-6e0sA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ekv | TOXIN COMPLEXCOMPONENT ORF-X2 (Clostridiumbotulinum) |
no annotation | 3 | LYS A 287ASN A 285SER A 268 | None | 1.25A | 5yw0A-6ekvA:undetectable | 5yw0A-6ekvA:17.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f9n | CLEAVAGE ANDPOLYADENYLATIONSPECIFICITY FACTORSUBUNIT 1 (Homo sapiens) |
no annotation | 3 | LYS A 64ASN A 44SER A 856 | None | 0.81A | 5yw0A-6f9nA:undetectable | 5yw0A-6f9nA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6g4q | SUCCINATE--COALIGASE [ADP-FORMING]SUBUNIT BETA,MITOCHONDRIAL (Homo sapiens) |
no annotation | 3 | LYS B 242ASN B 239SER B 70 | None | 1.11A | 5yw0A-6g4qB:undetectable | 5yw0A-6g4qB:undetectable |